Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
104 items found for 2021 [total: 1243]
Bacteriophage PRD1 as a nanoscaffold for drug loading Nanoscale, 156 Dec 2021 DOI: 10.1039/D1NR04153C
Structure-guided approach to relieving transcriptional repression in resistance to thyroid hormone α Molecular And Cellular Biology, 3 Dec 2021 DOI: 10.1128/MCB.00363-21
Insights into the mechanism of high lipid–detergent crystallization of membrane proteins Journal Of Applied Crystallography, 54 Dec 2021 DOI: 10.1107/S1600576721010669
Journal Paper I24-Microfocus Macromolecular Crystallography
Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling Nature Communications, 12 Dec 2021 DOI: 10.1038/s41467-021-27475-2
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure-guided discovery of aminoquinazolines as brain-penetrant and selective LRRK2 inhibitors Journal Of Medicinal Chemistry, 365 Dec 2021 DOI: 10.1021/acs.jmedchem.1c01968
Journal Paper I24-Microfocus Macromolecular Crystallography
The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract Plos Biology, 19 Dec 2021 DOI: 10.1371/journal.pbio.3001498
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography VMXi-Versatile Macromolecular Crystallography in situ open access
Human enzyme identified as potential key to treating lung and bladder cancer – increasing survival times Dec 2021
Science Highlight I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Experimental evidence for the benefits of higher X-ray energies for macromolecular crystallography Iucrj, 8 Nov 2021 DOI: 10.1107/S2052252521008423
The importance of adaptor proteins and cell signalling in the control of peptidoglycan synthesis Nov 2021
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer’s disease Cell, 184 Nov 2021 DOI: 10.1016/j.cell.2021.11.001
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure-based design of selective fat mass and obesity associated protein (FTO) inhibitors Journal Of Medicinal Chemistry, 276 Nov 2021 DOI: 10.1021/acs.jmedchem.1c01204
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Kinetic and structural properties of a robust bacterial L-amino acid oxidase Catalysts, 11 Nov 2021 DOI: 10.3390/catal11111309
Structural basis of Apt48 inhibition of the BCL6 BTB domain Structure, 66 Nov 2021 DOI: 10.1016/j.str.2021.10.010
Journal Paper I24-Microfocus Macromolecular Crystallography
Acquisition of ionic copper by the bacterial outer membrane protein OprC through a novel binding site Plos Biology, 19 Nov 2021 DOI: 10.1371/journal.pbio.3001446
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The structural basis for high affinity binding of α1-acid glycoprotein to the potent anti-tumour compound UCN-01 Journal Of Biological Chemistry, 12 Nov 2021 DOI: 10.1016/j.jbc.2021.101392
Kinetic and structural characterization of sialidases (Kdnases) from ascomycete fungal pathogens Acs Chemical Biology, 16 Nov 2021 DOI: 10.1021/acschembio.1c00666
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystallography and QM/MM simulations identify preferential binding of hydrolyzed carbapenem and penem antibiotics to the l1 metallo-β-lactamase in the imine form Journal Of Chemical Information And Modeling, Oct 2021 DOI: 10.1021/acs.jcim.1c00663
Journal Paper I24-Microfocus Macromolecular Crystallography
The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses Nucleic Acids Research, Oct 2021 DOI: 10.1093/nar/gkab906
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A single sulfatase is required to access colonic mucin by a gut bacterium Nature, 105 Oct 2021 DOI: 10.1038/s41586-021-03967-5
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Investigating the mechanism through which amino acids activate a conserved serine/threonine protein kinase in Actinobacteria Oct 2021
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural basis for silicic acid uptake by higher plants Journal Of Molecular Biology, 433 Oct 2021 DOI: 10.1016/j.jmb.2021.167226
Structural and evolutionary analyses of PR-4 SUGARWINs points to a different pattern of protein function Frontiers In Plant Science, 12 Sept 2021 DOI: 10.3389/fpls.2021.734248
Substrate specificity and conformational flexibility properties of the Mycobacterium tuberculosis β-oxidation trifunctional enzyme Journal Of Structural Biology, 213 Sept 2021 DOI: 10.1016/j.jsb.2021.107776
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Modelling the effects of optical vibrations on photon beam parameters using ray-tracing software Journal Of Synchrotron Radiation, 28 Sept 2021 DOI: 10.1107/S1600577521007013
A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19 Nature Communications, 12 Sept 2021 DOI: 10.1038/s41467-021-25480-z
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Molecular mechanism of sugar transport in plants unveiled by structures of glucose/H+ symporter STP10 Nature Plants, 4 Sept 2021 DOI: 10.1038/s41477-021-00992-0
Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production Nature Communications, 12 Sept 2021 DOI: 10.1038/s41467-021-25598-0
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Nonhydrolysable analogues of (p)ppGpp and (p)ppApp alarmone nucleotides as novel molecular tools Acs Chemical Biology, 3 Sept 2021 DOI: 10.1021/acschembio.1c00398
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure of the human marker of self 5-transmembrane receptor CD47 Nature Communications, 12 Sept 2021 DOI: 10.1038/s41467-021-25475-w
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Aspartate or arginine? Validated redox state X-ray structures elucidate mechanistic subtleties of FeIV = O formation in bacterial dye-decolorizing peroxidases Jbic Journal Of Biological Inorganic Chemistry, 65 Sept 2021 DOI: 10.1007/s00775-021-01896-2
Cooperative stabilisation of 14-3-3σ protein–protein interactions via covalent protein modification Chemical Science, 61 Sept 2021 DOI: 10.1039/D1SC02120F
Making molecular movies drop by drop Sept 2021
Science Highlight I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis Science Advances, 7 Aug 2021 DOI: 10.1126/sciadv.abh0250
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A topological switch in CFTR modulates channel activity and sensitivity to unfolding Nature Chemical Biology, 245 Aug 2021 DOI: 10.1038/s41589-021-00844-0
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The bacterial iron sensor IdeR recognizes its DNA targets by indirect readout Nucleic Acids Research, 25 Aug 2021 DOI: 10.1093/nar/gkab711
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
UbiD domain dynamics underpins aromatic decarboxylation Nature Communications, 12 Aug 2021 DOI: 10.1038/s41467-021-25278-z
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Molecular basis for DarT ADP-ribosylation of a DNA base Nature, 58 Aug 2021 DOI: 10.1038/s41586-021-03825-4
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Computational redesign of an ω-transaminase from Pseudomonas jessenii for asymmetric synthesis of enantiopure bulky amines Acs Catalysis, Aug 2021 DOI: 10.1021/acscatal.1c02053
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
X-ray molecular structure characterization of a hexamethylenetetramine zinc(II) porphyrin complex, catalytic degradation of toluidine blue dye, experimental and statistical studies of adsorption isotherms Journal Of Molecular Liquids, 24 Aug 2021 DOI: 10.1016/j.molliq.2021.117394
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition Nucleic Acids Research, 44 Aug 2021 DOI: 10.1093/nar/gkab693
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Kinetoplastid kinetochore proteins KKT2 and KKT3 have unique centromere localization domains Journal Of Cell Biology, 220 Aug 2021 DOI: 10.1083/jcb.202101022
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural insight into the unique conformation of cystathionine β-synthase from Toxoplasma gondii Computational And Structural Biotechnology Journal, 19 Aug 2021 DOI: 10.1016/j.csbj.2021.05.052
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12 Nature Structural & Molecular Biology, 7 Aug 2021 DOI: 10.1038/s41594-021-00636-z
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Conformational flexibility of a highly conserved helix controls cryptic pocket formation in FtsZ Journal Of Molecular Biology, 433 Jul 2021 DOI: 10.1016/j.jmb.2021.167061
The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding Nature Communications, 12 Jul 2021 DOI: 10.1038/s41467-021-24432-x
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain Structure, 62 Jul 2021 DOI: 10.1016/j.str.2021.06.010
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure and functional characterization of an oligosaccharide dehydrogenase from Pycnoporus cinnabarinus provides insights into fungal breakdown of lignocellulose Biotechnology For Biofuels, 14 Jul 2021 DOI: 10.1186/s13068-021-02003-y
Structure of an H3N2 influenza virus nucleoprotein Acta Crystallographica Section F Structural Biology Communications, 77 Jul 2021 DOI: 10.1107/S2053230X2100635X
Viruses that defeat microbe immunity could help fight drug-resistant bacteria Jul 2021
Diamond Annual Review Highlight I24-Microfocus Macromolecular Crystallography
Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1 Journal Of Biological Chemistry, 297 Jul 2021 DOI: 10.1016/j.jbc.2021.100837
Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis Nature Communications, 12 Jul 2021 DOI: 10.1038/s41467-021-24475-0
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography Nature Communications, 12 Jul 2021 DOI: 10.1038/s41467-021-24757-7
GH18 endo-β-n-acetylglucosaminidases use distinct mechanisms to process hybrid-type n-linked glycans Journal Of Biological Chemistry, 69 Jul 2021 DOI: 10.1016/j.jbc.2021.101011
Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer Science Translational Medicine, 13 Jul 2021 DOI: 10.1126/scitranslmed.aba4627
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal Nature Communications, 12 Jul 2021 DOI: 10.1038/s41467-021-24723-3
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Towards defining mechanisms involved in β-lactam resistance using serial crystallography Jul 2021
Thesis I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structural and functional characterization of PGRP-LB: modulation of the IMD immune pathway in pathogenic and mutualistic bacterial interactions Jul 2021
Thesis I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure-based optimization and discovery of M3258, a specific inhibitor of the immunoproteasome subunit LMP7 (β5i) Journal Of Medicinal Chemistry, 64 Jul 2021 DOI: 10.1021/acs.jmedchem.1c00604
Journal Paper I24-Microfocus Macromolecular Crystallography
Reversible covalent imine-tethering for selective stabilization of 14-3-3 hub protein interactions Journal Of The American Chemical Society, 143 June 2021 DOI: 10.1021/jacs.1c03035
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
An exploration of chemical properties required for cooperative stabilization of the 14-3-3 interaction with NF-κB—utilizing a reversible covalent tethering approach Journal Of Medicinal Chemistry, June 2021 DOI: 10.1021/acs.jmedchem.1c00401
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis Computational And Structural Biotechnology Journal, 19 June 2021 DOI: 10.1016/j.csbj.2021.06.006
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19 Scientific Reports, 11 June 2021 DOI: 10.1038/s41598-021-92416-4
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval Elife, 10 June 2021 DOI: 10.7554/eLife.68380
The structural basis of fatty acid elongation by the ELOVL elongases Nature Structural & Molecular Biology, 28 June 2021 DOI: 10.1038/s41594-021-00605-6
Journal Paper I24-Microfocus Macromolecular Crystallography
Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition Nature Communications, 12 June 2021 DOI: 10.1038/s41467-021-23800-x
Constructing ion channels from water-soluble α-helical barrels Nature Chemistry, 537 May 2021 DOI: 10.1038/s41557-021-00688-0
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
PGRP-LB: An inside view into the mechanism of the amidase reaction International Journal Of Molecular Sciences, 22 May 2021 DOI: 10.3390/ijms22094957
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Transfer of stabilising mutations between different secondary active transporter families Febs Open Bio, May 2021 DOI: 10.1002/2211-5463.13168
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Identification and characterization of the pyridoxal 5’-phosphate allosteric site in Escherichia coli pyridoxine 5’-phosphate oxidase Journal Of Biological Chemistry, 4 May 2021 DOI: 10.1016/j.jbc.2021.100795
Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases Journal Of Fluorine Chemistry, 30 May 2021 DOI: 10.1016/j.jfluchem.2021.109804
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis of metallo-β-lactamase inhibition by n-sulfamoylpyrrole-2-carboxylates Acs Infectious Diseases, 1277 May 2021 DOI: 10.1021/acsinfecdis.1c00104
Coiled coils 9-to-5: Rational de novo design of alpha-helical barrels with tunable oligomeric states Chemical Science, Apr 2021 DOI: 10.1039/D1SC00460C
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure, immunoreactivity, and in silico epitope determination of SmSPI S. mansoni serpin for immunodiagnostic application Vaccines, 9 Apr 2021 DOI: 10.3390/vaccines9040322
Structural characterization of KKT4, an unconventional microtubule-binding kinetochore protein Structure, 5 Apr 2021 DOI: 10.1016/j.str.2021.04.004
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Fungal GH25 muramidases: New family members with applications in animal nutrition and a crystal structure at 0.78Å resolution Plos One, 16 Mar 2021 DOI: 10.1371/journal.pone.0248190
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural resolution of switchable states of a de novo peptide assembly Nature Communications, 12 Mar 2021 DOI: 10.1038/s41467-021-21851-8
Functionalization of the BCL6 BTB domain into a noncovalent crystallization chaperone Iucrj, 8 Mar 2021 DOI: 10.1107/S2052252520015754
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity Journal Of Biological Chemistry, 271 Mar 2021 DOI: 10.1016/j.jbc.2021.100568
Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein Structure, 277 Mar 2021 DOI: 10.1016/j.str.2021.03.007
Characterisation of a tripartite α-pore forming toxin from Serratia marcescens Scientific Reports, 11 Mar 2021 DOI: 10.1038/s41598-021-85726-0
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death Cell Chemical Biology, 66 Mar 2021 DOI: 10.1016/j.chembiol.2021.02.006
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Query-guided protein–protein interaction inhibitor discovery Chemical Science, 19 Mar 2021 DOI: 10.1039/D1SC00023C
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure–functional relationship of cellular retinoic acid-binding proteins I and II interacting with natural and synthetic ligands Acta Crystallographica Section D Structural Biology, 77 Feb 2021 DOI: 10.1107/S2059798320015247
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Fixed target serial data collection at Diamond Light Source Journal Of Visualized Experiments, Feb 2021 DOI: 10.3791/62200
Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family Life Science Alliance, 4 Feb 2021 DOI: 10.26508/lsa.202000858
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly Plos Pathogens, 17 Feb 2021 DOI: 10.1371/journal.ppat.1009164
Structural analysis and biochemical properties of laccase enzymes from two Pediococcus species Microbial Biotechnology, 9 Feb 2021 DOI: 10.1111/1751-7915.13751
The first non‐helical Aib‐containing hexapeptide: The crystal structure of Z‐Gly‐Aib‐Gly‐Aib‐Gly‐Aib‐O t Bu Journal Of Peptide Science, 85 Feb 2021 DOI: 10.1002/psc.3307
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural characterisation of the regulation of the catalytic subunit of the COP9 signalosome: Identification of new opportunities for drug discovery Feb 2021
Thesis I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structure-based analyses of Salmonella RcsB variants unravel new features of the Rcs regulon Nucleic Acids Research, 162 Feb 2021 DOI: 10.1093/nar/gkab060
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice Nature Communications, 12 Feb 2021 DOI: 10.1038/s41467-021-21273-6
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Molecular basis for control of antibiotic production by a bacterial hormone Nature, 80 Feb 2021 DOI: 10.1038/s41586-021-03195-x
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation Chemical Science, 153 Jan 2021 DOI: 10.1039/D0SC05694D
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A non‐helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition The Embo Journal, 40 Jan 2021 DOI: 10.15252/embj.2020105164
Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization Nature Communications, 12 Jan 2021 DOI: 10.1038/s41467-020-20596-0
Structure of the complete dimeric human GDAP1 core domain provides insights into ligand binding and clustering of disease mutations Frontiers In Molecular Biosciences, 7 Jan 2021 DOI: 10.3389/fmolb.2020.631232
Journal Paper B21-High Throughput SAXS I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM Nature Methods, 18 Jan 2021 DOI: 10.1038/s41592-020-01001-6
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines Nature Communications, 12 Jan 2021 DOI: 10.1038/s41467-020-20478-5
A functional family of fluorescent nucleotide analogues to investigate actin dynamics and energetics Nature Communications, 12 Jan 2021 DOI: 10.1038/s41467-020-20827-4
Structural characterisation of a novel GPVI nanobody-complex reveals a biologically active domain-swapped GPVI dimer Blood, Jan 2021 DOI: 10.1182/blood.2020009440
A tamoxifen receptor within a voltage-gated sodium channel Molecular Cell, 350 Jan 2021 DOI: 10.1016/j.molcel.2020.12.048
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization Elife, 10 Jan 2021 DOI: 10.7554/eLife.63545
Structural characterisation of a carbohydrate binding domain of the human cation-independent mannose 6-phosphate/ IGF2 receptor Jan 2021
Thesis B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
High-resolution crystal structure of human pERp1, a saposin-like protein involved in IgA, IgM and integrin maturation in the endoplasmic reticulum Journal Of Molecular Biology, Jan 2021 DOI: 10.1016/j.jmb.2021.166826
- Helen M. E. Duyvesteyn, Isaac Santos-Perez, Francesca Peccati, Ane Martinez-Castillo, Thomas S. Walter, David Reguera, Felix M. Goñi, Gonzalo Jiménez-Osés, Hanna M. Oksanen, David I. Stuart, Nicola G. A. Abrescia, "Bacteriophage PRD1 as a nanoscaffold for drug loading", Nanoscale, 156 (2021), DOI: 10.1039/D1NR04153C
- Beatriz Romartinez-Alonso, Maura Agostini, Heulyn Jones, Jayde Mclellan, Deepali Sood, Nicholas Tomkinson, Federica Marelli, Ilaria Gentile, W. Edward Visser, Erik Schoenmakers, Louise Fairall, Martin Privalsky, Carla Moran, Luca Persani, Krishna Chatterjee, John Schwabe, "Structure-guided approach to relieving transcriptional repression in resistance to thyroid hormone α", Molecular And Cellular Biology, 3 (2021), DOI: 10.1128/MCB.00363-21
- Sofia Trampari, Caroline Neumann, Samuel J. Hjorth-Jensen, Azadeh Shahsavar, Esben M. Quistgaard, Poul Nissen, "Insights into the mechanism of high lipid–detergent crystallization of membrane proteins", Journal Of Applied Crystallography, 54 (2021), DOI: 10.1107/S1600576721010669
- Samuel C. Griffiths, Rebekka A. Schwab, Kamel El Omari, Benjamin Bishop, Ellen J. Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F. Covey, Robert J. C. Gilbert, Rajat Rohatgi, Christian Siebold, "Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling", Nature Communications, 12 (2021), DOI: 10.1038/s41467-021-27475-2
- Mitchell H. Keylor, Anmol Gulati, Solomon D. Kattar, Rebecca E. Johnson, Ryan W. Chau, Kaila A. Margrey, Michael J. Ardolino, Cayetana Zarate, Kelsey E. Poremba, Vladimir Simov, Gregori J. Morriello, John J. Acton, Barbara Pio, Xin Yan, Rachel L. Palte, Spencer E. Mcminn, Lisa Nogle, Charles A. Lesburg, Donovon Adpressa, Shishi Lin, Santhosh Neelamkavil, Ping Liu, Jing Su, Laxminarayan G. Hegde, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul J. Ciaccio, Jennifer Piesvaux, Karin M. Otte, Harold B. Wood, Matthew E. Kennedy, David Jonathan Bennett, Erin F. Dimauro, Matthew J. Fell, Peter H. Fuller, "Structure-guided discovery of aminoquinazolines as brain-penetrant and selective LRRK2 inhibitors", Journal Of Medicinal Chemistry, 365 (2021), DOI: 10.1021/acs.jmedchem.1c01968
- Haiyang Wu, Emmanuelle H. Crost, C. David Owen, Wouter Van Bakel, Ana Martínez Gascueña, Dimitrios Latousakis, Thomas Hicks, Samuel Walpole, Paulina A. Urbanowicz, Didier Ndeh, Serena Monaco, Laura Sánchez Salom, Ryan Griffiths, Raven S. Reynolds, Anna Colvile, Daniel I. R. Spencer, Martin Walsh, Jesus Angulo, Nathalie Juge, "The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract", Plos Biology, 19 (2021), DOI: 10.1371/journal.pbio.3001498
- [Science Highlight] Diamond Light Source, "Human enzyme identified as potential key to treating lung and bladder cancer – increasing survival times" (2021)
- Selina L. S. Storm, Danny Axford, Robin L. Owen, "Experimental evidence for the benefits of higher X-ray energies for macromolecular crystallography", Iucrj, 8 (2021), DOI: 10.1107/S2052252521008423
- [Thesis] Zoe Jane Rutter, "The importance of adaptor proteins and cell signalling in the control of peptidoglycan synthesis" (2021)
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