Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
88 items found for 2018 [total: 1243]
Binding of distinct substrate conformations enables hydroxylation of remote sites in thaxtomin D by cytochrome P450 TxtC Journal Of The American Chemical Society, Dec 2018 DOI: 10.1021/jacs.8b08864
Journal Paper I24-Microfocus Macromolecular Crystallography
Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7 Journal Of Medicinal Chemistry, Dec 2018 DOI: 10.1021/acs.jmedchem.8b01413
Ferredoxin-linked flavoenzyme defines a family of pyridine nucleotide-independent thioredoxin reductases Proceedings Of The National Academy Of Sciences, 239 Dec 2018 DOI: 10.1073/pnas.1812781115
Interactome rewiring following pharmacological targeting of BET bromodomains Molecular Cell, Dec 2018 DOI: 10.1016/j.molcel.2018.11.006
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps Journal Of Medicinal Chemistry, Dec 2018 DOI: 10.1021/acs.jmedchem.8b01292
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The molecular mechanism of transport by the mitochondrial ADP/ATP carrier Cell, Dec 2018 DOI: 10.1016/j.cell.2018.11.025
Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii Elife, 7 Dec 2018 DOI: 10.7554/eLife.42270
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure-guided design combined with evolutionary diversity led to the discovery of the xylose-releasing exo-xylanase activity in the glycoside hydrolase family 43 Biotechnology And Bioengineering, Dec 2018 DOI: 10.1002/bit.26899
Journal Paper I24-Microfocus Macromolecular Crystallography
Resolving polymorphs and radiation-driven effects in microcrystals using fixed-target serial synchrotron crystallography Acta Crystallographica Section D Structural Biology, 75 Nov 2018 DOI: 10.1107/S2059798318010240
Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design Cell, 175 Nov 2018 DOI: 10.1016/j.cell.2018.10.037
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation Nature Microbiology, 3 Nov 2018 DOI: 10.1038/s41564-018-0258-8
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structural insights into the function of type VI secretion system TssA subunits Nature Communications, 9 Nov 2018 DOI: 10.1038/s41467-018-07247-1
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases The Febs Journal, Nov 2018 DOI: 10.1111/febs.14695
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation Science, 362 Nov 2018 DOI: 10.1126/science.aar8048
Balancing specificity and promiscuity in enzyme evolution: multidimensional activity transitions in the alkaline phosphatase superfamily Journal Of The American Chemical Society, Nov 2018 DOI: 10.1021/jacs.8b10290
Journal Paper I24-Microfocus Macromolecular Crystallography
Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition Cell Chemical Biology, Nov 2018 DOI: 10.1016/j.chembiol.2018.10.015
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
(ADP-ribosyl)hydrolases: structural basis for differential substrate recognition and inhibition Cell Chemical Biology, Nov 2018 DOI: 10.1016/j.chembiol.2018.11.001
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis of H+-dependent conformational change in a bacterial MATE transporter Structure, Nov 2018 DOI: 10.1016/j.str.2018.10.004
Journal Paper I24-Microfocus Macromolecular Crystallography
The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs Nucleic Acids Research, Nov 2018 DOI: 10.1093/nar/gky1187
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural snapshots of OxyR reveal the peroxidatic mechanism of H2O2 sensing Proceedings Of The National Academy Of Sciences, 24 Nov 2018 DOI: 10.1073/pnas.1807954115
A potent and selective PARP11 inhibitor suggests coupling between cellular localization and catalytic activity Cell Chemical Biology, Oct 2018 DOI: 10.1016/j.chembiol.2018.09.011
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Maintaining and breaking symmetry in homomeric coiled-coil assemblies Nature Communications, 9 Oct 2018 DOI: 10.1038/s41467-018-06391-y
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells Cell, Oct 2018 DOI: 10.1016/j.cell.2018.08.033
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Non-equivalence of second sphere ‘non-catalytic’ residues in pentaerythritol tetranitrate reductase in relation to local dynamics linked to H-transfer in reactions with NADH and NADPH coenzymes Acs Catalysis, Oct 2018 DOI: 10.1021/acscatal.8b02810
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for recognition and repair of the 3′-phosphate by NExo, a base excision DNA repair nuclease from Neisseria meningitidis Nucleic Acids Research, 39 Oct 2018 DOI: 10.1093/nar/gky934
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Holliday junctions formed from human telomeric DNA Journal Of The American Chemical Society, Oct 2018 DOI: 10.1021/jacs.8b08699
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens Nature, 47 Oct 2018 DOI: 10.1038/s41586-018-0653-6
The quaternary structure of Thermus thermophilus aldehyde dehydrogenase is stabilized by an evolutionary distinct C-terminal arm extension Scientific Reports, 8 Sept 2018 DOI: 10.1038/s41598-018-31724-8
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Insights into kinesin-1 activation from the crystal structure of KLC2 bound to JIP3 Structure, Sept 2018 DOI: 10.1016/j.str.2018.07.011
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33 Acta Crystallographica Section D Structural Biology, 74 Sept 2018 DOI: 10.1107/S205979831800904X
Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones Nature Communications, 9 Sept 2018 DOI: 10.1038/s41467-018-06192-3
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1 Nucleic Acids Research, 5 Sept 2018 DOI: 10.1093/nar/gky863
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, Sept 2018 DOI: 10.1016/j.bbapap.2018.09.005
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Substrate recognition and autoinhibition in the central ribonuclease RNase E Molecular Cell, Sept 2018 DOI: 10.1016/j.molcel.2018.08.039
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding Nature Communications, 9 Aug 2018 DOI: 10.1038/s41467-018-05459-z
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A key role for the periplasmic PfeE esterase in iron acquisition via the siderophore Enterobactin in Pseudomonas aeruginosa Acs Chemical Biology, Aug 2018 DOI: 10.1021/acschembio.8b00543
Journal Paper I24-Microfocus Macromolecular Crystallography
Roles of distal aspartate and arginine of B-class dye-decolorizing peroxidase in heterolytic hydrogen peroxide cleavage Journal Of Biological Chemistry, Aug 2018 DOI: 10.1074/jbc.RA118.004773
Crystal structures of Z–Gly–Aib–O−·0.5Ca2+·H2O and Z–Gly–Aib–OH Acta Crystallographica Section E Crystallographic Communications, 74 Aug 2018 DOI: 10.1107/S2056989018010745
Arabidopsis downy mildew effector HaRxL106 suppresses plant immunity by binding to RADICAL-INDUCED CELL DEATH1 New Phytologist, 220 Aug 2018 DOI: 10.1111/nph.15277
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis of cross-reactivity of anti-citrullinated protein antibodies Arthritis & Rheumatology, Aug 2018 DOI: 10.1002/art.40698
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Studying the mechanism and action of Purine biosynthesis enzymes in Mycobacterium Tuberculosis H37RV Aug 2018
Thesis I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Mechanistic exploitation of a self-repairing, blocked proton transfer pathway in an O2-tolerant [NiFe]-hydrogenase Journal Of The American Chemical Society, Aug 2018 DOI: 10.1021/jacs.8b04798
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds Science Advances, 4 Aug 2018 DOI: 10.1126/sciadv.aat2720
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
An aspartate-specific solute-binding protein regulates protein kinase G activity to control glutamate metabolism in mycobacteria Mbio, 9 Jul 2018 DOI: 10.1128/mBio.00931-18
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset Proceedings Of The National Academy Of Sciences, 47 Jul 2018 DOI: 10.1073/pnas.1607817115
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure–function analyses of the bacterial zinc metalloprotease effector protein GtgA uncovers key residues required for deactivating NF-κB Journal Of Biological Chemistry, Jul 2018 DOI: 10.1074/jbc.RA118.004255
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Surface probing by fragment-based screening and computational methods identifies ligandable pockets on the von Hippel-Lindau (VHL) E3 ubiquitin ligase Journal Of Medicinal Chemistry, Jul 2018 DOI: 10.1021/acs.jmedchem.8b00842
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Stereo- and regioselectivity in catalyzed transformation of a 1,2-disubstituted vicinal diol and the corresponding diketone by wild type and laboratory evolved alcohol dehydrogenases Acs Catalysis, Jul 2018 DOI: 10.1021/acscatal.8b01762
Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase Nature Communications, 9 Jul 2018 DOI: 10.1038/s41467-018-05005-x
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Hepatitis A virus capsid structure Cold Spring Harbor Perspectives In Medicine, Jul 2018 DOI: 10.1101/cshperspect.a031807
Structural basis of malodour precursor transport in the human axilla Elife, 7 Jul 2018 DOI: 10.7554/eLife.34995
Mechanism of parkin activation by PINK1 Nature, June 2018 DOI: 10.1038/s41586-018-0224-x
Journal Paper I24-Microfocus Macromolecular Crystallography
Enzyme catalysis captured using multiple structures from one crystal at varying temperatures Iucrj, 5 May 2018 DOI: 10.1107/S205225251800386X
Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase Acs Catalysis, May 2018 DOI: 10.1021/acscatal.8b00867
Journal Paper I24-Microfocus Macromolecular Crystallography
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability Bioorganic & Medicinal Chemistry, May 2018 DOI: 10.1016/j.bmc.2018.05.003
Structural and functional determination of homologs of the Mycobacterium tuberculosis N -acetylglucosamine-6-phosphate deacetylase (NagA) Journal Of Biological Chemistry, May 2018 DOI: 10.1074/jbc.RA118.002597
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
X-ray crystal structures of the type IVb secretion system DotB ATPases Protein Science, May 2018 DOI: 10.1002/pro.3439
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Novel non-ATP competitive small molecules targeting the CK2 α/β interface Bioorganic & Medicinal Chemistry, May 2018 DOI: 10.1016/j.bmc.2018.05.011
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site Nature Communications, 9 May 2018 DOI: 10.1038/s41467-018-04045-7
The C-terminal extension landscape of naturally presented HLA-I ligands Proceedings Of The National Academy Of Sciences, 115 May 2018 DOI: 10.1073/pnas.1717277115
Journal Paper I24-Microfocus Macromolecular Crystallography
Structures of ebolavirus glycoprotein complexes with tricyclic antidepressant and antipsychotic drugs Journal Of Medicinal Chemistry, May 2018 DOI: 10.1021/acs.jmedchem.8b00350
An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor Biochemical Journal, May 2018 DOI: 10.1042/BCJ20180171
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2( 1H )-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition Bioorganic & Medicinal Chemistry, Apr 2018 DOI: 10.1016/j.bmc.2018.04.033
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Unusual constriction zones in the major porins OmpU and OmpT from Vibrio cholerae Structure, Apr 2018 DOI: 10.1016/j.str.2018.03.010
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor Acta Crystallographica Section F Structural Biology Communications, 74 Mar 2018 DOI: 10.1107/S2053230X18001553
Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures Proceedings Of The National Academy Of Sciences, 265 Mar 2018 DOI: 10.1073/pnas.1710741115
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural basis for the specific neutralization of Stx2a with a camelid single domain antibody fragment Toxins, 10 Mar 2018 DOI: 10.3390/toxins10030108
Structures of monomeric and oligomeric forms of the Toxoplasma gondii perforin-like protein 1 Science Advances, 4 Mar 2018 DOI: 10.1126/sciadv.aaq0762
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Targeting ligandable pockets on PHD zinc finger domains by a fragment-based approach Acs Chemical Biology, Mar 2018 DOI: 10.1021/acschembio.7b01093
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis Nature Communications, 9 Mar 2018 DOI: 10.1038/s41467-018-03477-5
The partial dissociation of MHC class I bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1 Journal Of Biological Chemistry, Mar 2018 DOI: 10.1074/jbc.RA117.000313
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Halogen-aromatic π-interactions modulate inhibitor residence time Angewandte Chemie International Edition, Mar 2018 DOI: 10.1002/anie.201801666
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors Science Advances, 4 Mar 2018 DOI: 10.1126/sciadv.aap9714
Conformational flexibility of proteins involved in ribosome biogenesis: investigations via Small Angle X-Ray Scattering (SAXS) Crystals, 8 Feb 2018 DOI: 10.3390/cryst8030109
Structural basis for amino acid transport by the CAT family of SLC7 transporters Nature Communications, 9 Feb 2018 DOI: 10.1038/s41467-018-03066-6
Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system Nature Communications, 9 Feb 2018 DOI: 10.1038/s41467-017-02578-x
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE: a molecular basis for domain-selectivity The Febs Journal, Feb 2018 DOI: 10.1111/febs.14421
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure-based optimization strategies for G protein-coupled receptor (GPCR) allosteric modulators: a case study from analyses of new metabotropic glutamate receptor 5 (mGlu5) x-ray structures Journal Of Medicinal Chemistry, Feb 2018 DOI: 10.1021/acs.jmedchem.7b01722
Journal Paper I24-Microfocus Macromolecular Crystallography
Second-generation CK2α inhibitors targeting the αD pocket Chemical Science, 9 Feb 2018 DOI: 10.1039/C7SC05122K
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Characterization of the fast and promiscuous macrocyclase from plant PCY1 enables the use of simple substrates Acs Chemical Biology, Jan 2018 DOI: 10.1021/acschembio.8b00050
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction Nature Communications, 9 Jan 2018 DOI: 10.1038/s41467-017-02312-7
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 Nature, 553 Jan 2018 DOI: 10.1038/nature25025
Journal Paper I24-Microfocus Macromolecular Crystallography
Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action Proceedings Of The National Academy Of Sciences, 115 Jan 2018 DOI: 10.1073/pnas.1707856115
Journal Paper I24-Microfocus Macromolecular Crystallography
The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance Plos Pathogens, 14 Jan 2018 DOI: 10.1371/journal.ppat.1006849
Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer Cancer Research, Jan 2018 DOI: 10.1158/0008-5472.CAN-17-2870
CDKL family kinases have evolved distinct structural features and ciliary function Cell Reports, 22 Jan 2018 DOI: 10.1016/j.celrep.2017.12.083
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
A study of the molecular regulation of trypanosomatid phosphofructokinases as drug targets Jan 2018
Thesis I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals Scientific Reports, 8 Jan 2018 DOI: 10.1038/s41598-017-18570-w
- Lona M. Alkhalaf, Sarah Barry, Dean Rea, Angelo Gallo, Daniel Griffiths, Jozef Lewandowski, Vilmos Fulop, Gregory L. Challis, "Binding of distinct substrate conformations enables hydroxylation of remote sites in thaxtomin D by cytochrome P450 TxtC", Journal Of The American Chemical Society (2018), DOI: 10.1021/jacs.8b08864
- Vittoria Zoppi, Scott J. Hughes, Chiara Maniaci, Andrea Testa, Teresa Gmaschitz, Corinna Wieshofer, Manfred Koegl, Kristin Riching, Danette L. Daniels, Andrea Spallarossa, Alessio Ciulli, "Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b01413
- Ruben M. Buey, David Fernandez-Justel, Jose M. De Pereda, José L. Revuelta, Peter Schürmann, Bob B. Buchanan, Monica Balsera, "Ferredoxin-linked flavoenzyme defines a family of pyridine nucleotide-independent thioredoxin reductases", Proceedings Of The National Academy Of Sciences, 239 (2018), DOI: 10.1073/pnas.1812781115
- Jean-Philippe Lambert, Sarah Picaud, Takao Fujisawa, Huayun Hou, Pavel Savitsky, Liis Uusküla-Reimand, Gagan D. Gupta, Hala Abdouni, Zhen-Yuan Lin, Monika Tucholska, James D. R. Knight, Beatriz Gonzalez-Badillo, Nicole St-Denis, Joseph A. Newman, Manuel Stucki, Laurence Pelletier, Nuno Bandeira, Michael D. Wilson, Panagis Filippakopoulos, Anne-Claude Gingras, "Interactome rewiring following pharmacological targeting of BET bromodomains", Molecular Cell (2018), DOI: 10.1016/j.molcel.2018.11.006
- Gydo C. P. Van Zundert, Brandi M. Hudson, Saulo H. P. De Oliveira, Daniel Keedy, Rasmus Fonseca, Amelie Heliou, Pooja Suresh, Kenneth Borrelli, Tyler Day, James Fraser, Henry Van Den Bedem, "qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b01292
- Jonathan J. Ruprecht, Martin S. King, Thomas Zogg, Antoniya A. Aleksandrova, Els Pardon, Paul G. Crichton, Jan Steyaert, Edmund R. S. Kunji, "The molecular mechanism of transport by the mitochondrial ADP/ATP carrier", Cell (2018), DOI: 10.1016/j.cell.2018.11.025
- Lucile Moynie, Ilaria Serra, Mariano A. Scorciapino, Emilia Oueis, Malcolm G. P. Page, Matteo Ceccarelli, James Naismith, "Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii", Elife, 7 (2018), DOI: 10.7554/eLife.42270
- Letícia Maria Zanphorlin, Mariana Abrahão Bueno De Morais, José Alberto Diogo, Mariane Noronha Domingues, Flávio Henrique Moreira De Souza, Roberto Ruller, Mario Murakami, "Structure-guided design combined with evolutionary diversity led to the discovery of the xylose-releasing exo-xylanase activity in the glycoside hydrolase family 43", Biotechnology And Bioengineering (2018), DOI: 10.1002/bit.26899
- Ali Ebrahim, Martin V. Appleby, Danny Axford, John Beale, Tadeo Moreno-Chicano, Darren A. Sherrell, Richard W. Strange, Michael A. Hough, Robin L. Owen, "Resolving polymorphs and radiation-driven effects in microcrystals using fixed-target serial synchrotron crystallography", Acta Crystallographica Section D Structural Biology, 75 (2018), DOI: 10.1107/S2059798318010240
- Yin Yao Dong, Hua Wang, Ashley C. W. Pike, Stephen A. Cochrane, Sadra Hamedzadeh, Filip J. Wyszyński, Simon R. Bushell, Sylvain F. Royer, David A. Widdick, Andaleeb Sajid, Helena I. Boshoff, Yumi Park, Ricardo Lucas, Wei-Min Liu, Seung Seo Lee, Takuya Machida, Leanne Minall, Shahid Mehmood, Katsiaryna Belaya, Wei-Wei Liu, Amy Chu, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, Claire Strain-Damerell, Rod Chalk, Nicola A. Burgess-Brown, Mervyn J. Bibb, Clifton E. Barry, Carol V. Robinson, David Beeson, Benjamin G. Davis, Elizabeth P. Carpenter, "Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design", Cell, 175, 1045 - 1058.e16 (2018), DOI: 10.1016/j.cell.2018.10.037
- Alan Cartmell, Jose Muñoz-Muñoz, Jonathon A. Briggs, Didier A. Ndeh, Elisabeth C. Lowe, Arnaud Basle, Nicolas Terrapon, Katherine Stott, Tiaan Heunis, Joe Gray, Li Yu, Paul Dupree, Pearl Z. Fernandes, Sayali Shah, Spencer J. Williams, Aurore Labourel, Matthias Trost, Bernard Henrissat, Harry J. Gilbert, "A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation", Nature Microbiology, 3, 1314 - 1326 (2018), DOI: 10.1038/s41564-018-0258-8
- Samuel R. Dix, Hayley J. Owen, Ruyue Sun, Asma Ahmad, Sravanthi Shastri, Helena L. Spiewak, Daniel J. Mosby, Matthew J. Harris, Sarah L. Batters, Thomas A. Brooker, Svetomir B. Tzokov, Svetlana E. Sedelnikova, Patrick J. Baker, Per A. Bullough, David W. Rice, Mark S. Thomas, "Structural insights into the function of type VI secretion system TssA subunits", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-07247-1
- Ramya Salimraj, Philip Hinchliffe, Magda Kosmopoulou, Jonathan M. Tyrrell, Jurgen Brem, Sander S. Van Berkel, Anil Verma, Raymond J. Owens, Michael A. Mcdonough, Timothy R. Walsh, Christopher J. Schofield, James Spencer, "Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases", The Febs Journal (2018), DOI: 10.1111/febs.14695
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- Peter Canning, Kwangjin Park, João Gonçalves, Chunmei Li, Conor J. Howard, Timothy D. Sharpe, Liam J. Holt, Laurence Pelletier, Alex N. Bullock, Michel R. Leroux, "CDKL family kinases have evolved distinct structural features and ciliary function", Cell Reports, 22, 885 - 894 (2018), DOI: 10.1016/j.celrep.2017.12.083
- [Thesis] James R. H. Kinkead, "A study of the molecular regulation of trypanosomatid phosphofructokinases as drug targets" (2018)
- Prakash Rucktooa, Robert K. Y. Cheng, Elena Segala, Tian Geng, James C. Errey, Giles A. Brown, Robert M. Cooke, Fiona H. Marshall, Andrew S. Dore, "Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals", Scientific Reports, 8 (2018), DOI: 10.1038/s41598-017-18570-w
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