Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
19 items found for 2011 [total: 1243]
Recognition of dual symmetry by the controller protein C.Esp1396I based on the structure of the transcriptional activation complex Nucleic Acids Research, 40 (9) Dec 2011 DOI: 10.1093/nar/gkr1250
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1 Nature Structural & Molecular Biology, 18 (8) Dec 2011 DOI: 10.1038/nsmb.2081
The N-terminus of the RNA polymerase from infectious pancreatic necrosis virus is the determinant of genome attachment Plos Pathogens, 7 (6) Dec 2011 DOI: 10.1371/journal.ppat.1002085
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling Developmental Cell, 21 Dec 2011 DOI: 10.1016/j.devcel.2011.09.007
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome Proteins: Structure, Function And Bioinformatics, 80 (2) Dec 2011 DOI: 10.1002/prot.23208
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family Journal Of Biological Chemistry, 286 Nov 2011 DOI: 10.1074/jbc.M111.283689
Design, synthesis, and evaluation of 5′-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase Chemmedchem, 6 (10) Oct 2011 DOI: 10.1002/cmdc.201100255
How to change the oligomeric state of a circular protein assembly: switch from 11-subunit to 12-subunit TRAP suggests a general mechanism Plos One, 6 (10) Oct 2011 DOI: 10.1371/journal.pone.0025296
Structure of the adenosine A2A receptor in complex with ZM241385 and the xanthines XAC and caffeine Structure, 19 (9) Sept 2011 DOI: 10.1016/j.str.2011.06.014
Journal Paper I24-Microfocus Macromolecular Crystallography
Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin Biochemical Journal, 438 (2) Sept 2011 DOI: 10.1042/BJ20101316
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Expression, purification and crystallization of Neisserial outer membrane proteins Sept 2011 DOI: 10.1007/978-1-61779-346-2_6
Book Chapter I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural characterization of angiotensin-I converting enzyme in complex with a selenium analogue of captopril Febs Journal, Aug 2011 DOI: 10.1111/j.1742-4658.2011.08276.x
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of the human histamine H1 receptor complex with doxepin Nature, 475 June 2011 DOI: 10.1038/nature10236
Journal Paper I24-Microfocus Macromolecular Crystallography
X-ray crystallographic structure of the murine norovirus protease at 1.66 Å resolution and functional studies of the β-ribbon June 2011
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation Nature, 474 May 2011 DOI: 10.1038/nature10136
Journal Paper I24-Microfocus Macromolecular Crystallography
Pi sampling: a methodical and flexible approach to initial macromolecular crystallization screening Acta Crystallographica Section D Biological Crystallography, 67 (5) May 2011 DOI: 10.1107/S0907444911008754
Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability Biochemistry, 50 (12) Feb 2011 DOI: 10.1021/bi101936c
Journal Paper I24-Microfocus Macromolecular Crystallography
Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain Journal Of Biological Chemistry, 286 (5) Jan 2011 DOI: 10.1074/jbc.M110.188193
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The design of macromolecular crystallography diffraction experiments Acta Crystallographica Section D, 67 (4) Jan 2011 DOI: 10.1107/S0907444911007608
- J. E. Mcgeehan, N. J. Ball, S. D. Streeter, S.-J. Thresh, G. G. Kneale, "Recognition of dual symmetry by the controller protein C.Esp1396I based on the structure of the transcriptional activation complex", Nucleic Acids Research, 40 (9), 4158-4167. (2011), DOI: 10.1093/nar/gkr1250
- Tomas Malinauskas, Alexandru Aricescu, Weixian Lu, Christian Siebold, E. Yvonne Jones, "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1", Nature Structural & Molecular Biology, 18 (8), 886-893 (2011), DOI: 10.1038/nsmb.2081
- Stephen C. Graham, L. Peter Sarin, Mohammad W. Bahar, Reg A Myers, Dave I. Stuart, Dennis H. Bamford, Jonathan M. Grimes, "The N-terminus of the RNA polymerase from infectious pancreatic necrosis virus is the determinant of genome attachment", Plos Pathogens, 7 (6) (2011), DOI: 10.1371/journal.ppat.1002085
- Shuo Chen, Doryen Bubeck, Bryan T. Macdonald, Wen-Xue Liang, Jian-Hua Mao, Tomas Malinauskas, Oscar Llorca, Alexandru Aricescu, Christian Siebold, Xi He, E. Yvonne Jones, "Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling", Developmental Cell, 21, 848 - 861 (2011), DOI: 10.1016/j.devcel.2011.09.007
- Kamel El Omari, Julie De Mesmaeker, Dimple Karia, Helen Ginn, Shoumo Bhattacharya, Erika J. Mancini, "Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome", Proteins: Structure, Function And Bioinformatics, 80 (2), 655 - 660, (2011), DOI: 10.1002/prot.23208
- Lars Hillringhaus, Wyatt Yue, Nathan Rose, Stanley S. Ng, Carina Gileadi, Christoph Loenarz, Simon H. Bello, James E. Bray, Christopher J. Schofield, Udo Oppermann, "Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family", Journal Of Biological Chemistry, 286, 41616 - 41625 (2011), DOI: 10.1074/jbc.M111.283689
- Shahienaz E. Hampton, Beatriz Baragaña, Alessandro Schipani, Cristina Bosch-Navarrete, J. Alexander Musso-Buendía, Eliseo Recio, Marcel Kaiser, Jean L. Whittingham, Shirley M. Roberts, Mikhail Shevtsov, James A. Brannigan, Pia Kahnberg, Reto Brun, Keith S. Wilson, Dolores González-Pacanowska, Nils Gunnar Johansson, Ian H. Gilbert, "Design, synthesis, and evaluation of 5′-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase", Chemmedchem, 6 (10), 1816 - 1831 (2011), DOI: 10.1002/cmdc.201100255
- Chao-Sheng Chen, Callum Smits, Guy G. Dodson, Mikhail Shevtsov, Natalie Merlino, Paul Gollnick, Alfred A. Antson, "How to change the oligomeric state of a circular protein assembly: switch from 11-subunit to 12-subunit TRAP suggests a general mechanism", Plos One, 6 (10) (2011), DOI: 10.1371/journal.pone.0025296
- Andrew S. Dore, Nathan Robertson, James C. Errey, Irene Ng, Kaspar Hollenstein, Ben Tehan, Edward Hurrell, Kirstie Bennett, Miles Congreve, Francesca Magnani, Christopher G. Tate, Malcolm Weir, Fiona H. Marshall, "Structure of the adenosine A2A receptor in complex with ZM241385 and the xanthines XAC and caffeine", Structure, 19 (9), 1283 - 1293 (2011), DOI: 10.1016/j.str.2011.06.014
- Daniel A. East, Duncan Sousa, Stephen R. Martin, Thomas A. Edwards, William Lehman, Daniel P. Mulvihill, "Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin", Biochemical Journal, 438 (2), 265 - 273 (2011), DOI: 10.1042/BJ20101316
- [Book Chapter] Muhammad Saleem, Jeremy Moore, Jeremy Derrick, "Expression, purification and crystallization of Neisserial outer membrane proteins" (2011), DOI: 10.1007/978-1-61779-346-2_6
- Akif Mohd, Geoffrey Masuyer, Sylva L. U. Schwager, Bhaskar J. Bhuyan, Govindasamy Mugesh, R Elwyn Isaac, Edward D. Sturrock, K, Ravi Acharya, "Structural characterization of angiotensin-I converting enzyme in complex with a selenium analogue of captopril", Febs Journal (2011), DOI: 10.1111/j.1742-4658.2011.08276.x
- Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens, So Iwata, "Structure of the human histamine H1 receptor complex with doxepin", Nature, 475, 65 - 70 (2011), DOI: 10.1038/nature10236
- [Thesis] Gabriela Baeza, "X-ray crystallographic structure of the murine norovirus protease at 1.66 Å resolution and functional studies of the β-ribbon" (2011)
- Guillaume Lebon, Tony Warne, Patricia C. Edwards, Kirstie Bennett, Christopher J. Langmead, Andrew G. W. Leslie, Christopher G. Tate, "Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation", Nature, 474, 521 - 525 (2011), DOI: 10.1038/nature10136
- Fabrice Gorrec, Colin M. Palmer, Gui Lebon, Tony Warne, "Pi sampling: a methodical and flexible approach to initial macromolecular crystallization screening", Acta Crystallographica Section D Biological Crystallography, 67 (5), 463 - 470 (2011), DOI: 10.1107/S0907444911008754
- Karen E. Marshall, Kyle L. Morris, Deborah Charlton, Nicola O'Reilly, Laurence Lewis, Helen Walden, Louise C. Serpell, "Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability", Biochemistry, 50 (12) (2011), DOI: 10.1021/bi101936c
- T. Tanaka, H. Sewell, S. Waters, S. E. V. Phillips, T. H. Rabbitts, "Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain", Journal Of Biological Chemistry, 286 (5), 3707 - 3716 (2011), DOI: 10.1074/jbc.M110.188193
- Gwyndaf Evans, Danny Axford, Robin L. Owen, "The design of macromolecular crystallography diffraction experiments", Acta Crystallographica Section D, 67 (4), 261-270 (2011), DOI: 10.1107/S0907444911007608
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