Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
44 items found for 2012 [total: 1243]
Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein Structure, Dec 2012 DOI: 10.1016/j.str.2012.10.017
Journal Paper I24-Microfocus Macromolecular Crystallography
How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity Proceedings Of The National Academy Of Sciences, Dec 2012 DOI: 10.1073/pnas.1212034109
Structure of a pestivirus envelope glycoprotein E2 clarifies its role in cell entry Cell Reports, Dec 2012 DOI: 10.1016/j.celrep.2012.12.001
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structures of MBOgg1 in complex with two abasic DNA ligands Journal Of Structural Biology, 181 (3) Dec 2012 DOI: 10.1016/j.jsb.2012.12.003
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster Journal Of The American Chemical Society, 135 (4) Dec 2012 DOI: 10.1021/ja308952y
Journal Paper I24-Microfocus Macromolecular Crystallography
Bioenergetics at extreme temperature: structural and functional studies of complexes II and IV of Thermus thermophilus Dec 2012 DOI: 10.34961/2587
Thesis I24-Microfocus Macromolecular Crystallography
High resolution crystal structure of Sco5413, a widespread actinomycete MarR family transcriptional regulator of unknown function Proteins: Structure, Function, And Bioinformatics, Nov 2012 DOI: 10.1002/prot.24197
The crystal structure of samarosporin I at atomic resolution Journal Of Peptide Science, 18 (11) Nov 2012 DOI: 10.1002/psc.2454
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural and functional analyses of the interaction of archaeal RNA polymerase with DNA Nucleic Acids Research, 40 (19) Oct 2012 DOI: 10.1093/nar/gks692
Dissecting fragment-based lead discovery at the von Hippel-Lindau protein:hypoxia inducible factor 1α protein-protein interface Chemistry & Biology, 19 (10) Oct 2012 DOI: 10.1016/j.chembiol.2012.08.015
Journal Paper I24-Microfocus Macromolecular Crystallography
The crystal structure of the 14-residue peptaibol trichovirin at atomic resolution JOURNAL OF PEPTIDE SCIENCE, 18 Sept 2012
Conference Paper I24-Microfocus Macromolecular Crystallography
Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase Nature Structural & Molecular Biology, 19 (8) Aug 2012 DOI: 10.1038/nsmb.2329
BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer Nature Structural & Molecular Biology, 19 (9) Aug 2012 DOI: 10.1038/nsmb.2379
TCR/pMHC optimized protein crystallization screen Journal Of Immunological Methods, 382 Aug 2012 DOI: 10.1016/j.jim.2012.06.007
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The molecular basis of ubiquitin-like protein NEDD8 deamidation by the bacterial effector protein Cif Proceedings Of The National Academy Of Sciences, 109 (27) Jul 2012 DOI: 10.1073/pnas.1112107109
Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1 Proceedings Of The National Academy Of Sciences, 109 (31) Jul 2012 DOI: 10.1073/pnas.1204991109
The crystal structure of the extracellular 11-heme cytochrome UndA reveals a conserved 10-heme motif and defined binding site for soluble iron chelates Structure, 20 (7) Jul 2012 DOI: 10.1016/j.str.2012.04.016
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural insights into electron transfer in caa3-type cytochrome oxidase Nature, 487 Jul 2012 DOI: 10.1038/nature11182
Journal Paper I24-Microfocus Macromolecular Crystallography
Outrunning free radicals in room-temperature macromolecular crystallography Acta Crystallographica Section D, 68 (7) Jul 2012 DOI: 10.1107/S0907444912012553
The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks Nature Structural & Molecular Biology, 19 (7) June 2012 DOI: 10.1038/nsmb.2335
Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (6) June 2012 DOI: 10.1107/S1744309112017915
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function Biochemistry, 51(25) May 2012 DOI: 10.1021/bi300150y
Journal Paper I24-Microfocus Macromolecular Crystallography
Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol Structure, 20 (5) May 2012 DOI: 10.1016/j.str.2012.03.014
X-ray-excited optical luminescence of protein crystals: a new tool for studying radiation damage during diffraction data collection Acta Crystallographica Section D Biological Crystallography, 68 (5) May 2012 DOI: 10.1107/S0907444912002946
Crystallization and preliminary crystallographic analysis of the major capsid proteins VP16 and VP17 of bacteriophage P23-77 Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (5) May 2012 DOI: 10.1107/S1744309112010330
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The CDK9 C-helix exhibits conformational plasticity that may explain the selectivity of CAN508 Acs Chemical Biology, 7 (5) May 2012 DOI: 10.1021/cb2004516
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Fast high-pressure freezing of protein crystals in their mother liquor Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (4) Apr 2012 DOI: 10.1107/S1744309112009670
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: SAR, structural biology and cellular activity Journal Of Medicinal Chemistry, 55 (7) Apr 2012 DOI: 10.1021/jm201683b
Journal Paper I24-Microfocus Macromolecular Crystallography
Promoting crystallisation of the Salmonella enteritidis fimbriae 14 pilin SefD using deuterium oxide Biochemical And Biophysical Research Communications, 421 (2) Apr 2012 DOI: 10.1016/j.bbrc.2012.03.136
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex Developmental Cell, 22 (5) Apr 2012 DOI: 10.1016/j.devcel.2012.01.018
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly Open Biology, 2 Apr 2012 DOI: 10.1098/rsob.120028
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of Escherichia coli OmpF porin from lipidic mesophase Journal Of Structural Biology, 178 (3) Mar 2012 DOI: 10.1016/j.jsb.2012.03.005
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71 Nature Structural & Molecular Biology, 19 (4) Mar 2012 DOI: 10.1038/nsmb.2255
Discovery of 1,2,4-triazine derivatives as adenosine A2A antagonists using structure based drug design Journal Of Medicinal Chemistry, 55 (5) Mar 2012 DOI: 10.1021/jm201376w
An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid Nature Communications, 3 Feb 2012 DOI: 10.1038/ncomms1680
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody Nature, 482 Feb 2012 DOI: 10.1038/nature10750
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure of yeast kinetochore Ndc10 DNA-binding domain reveals unexpected evolutionary relationship to tyrosine recombinases Journal Of Biological Chemistry, 287 (7) Feb 2012 DOI: 10.1074/jbc.C111.318501
Four complete turns of a curved 3 10-helix at atomic resolution: the crystal structure of the peptaibol trichovirin I-4A in a polar environment suggests a transition to [alpha]-helix for membrane function Acta Crystallographica Section D Biological Crystallography, 68 (2) Feb 2012 DOI: 10.1107/S090744491105133X
Journal Paper I24-Microfocus Macromolecular Crystallography
Refolding, purification and crystallization of the FrpB outer membrane iron transporter from Neisseria meningitidis Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (2) Feb 2012 DOI: 10.1107/S1744309111056028
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure of HDAC3 bound to corepressor and inositol tetraphosphate Nature, Jan 2012 DOI: 10.1038/nature10728
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating Nature Structural & Molecular Biology, Jan 2012 DOI: 10.1038/nsmb.2208
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes Nature Immunology, Jan 2012 DOI: 10.1038/ni.2206
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and mechanistic insight into N-glycan processing by endo- -mannosidase Proceedings Of The National Academy Of Sciences, Jan 2012 DOI: 10.1073/pnas.1111482109
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands Journal Of The American Chemical Society, 134 (5) Jan 2012 DOI: 10.1021/ja2102423
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
- Michael A. Dimattia, Norman R. Watts, Stephen j. Stahl, Jonathan M. Grimes, Alasdair C. Steven, David I. Stuart, Paul T. Wingfield, "Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein", Structure (2012), DOI: 10.1016/j.str.2012.10.017
- Fiona Cuskin, James E. Flint, Tracey M. Gloster, Carl Morland, Arnaud Basle, Bernard Henrissat, Pedro M. Coutinho, Andrea Strazzulli, Alexandra S. Solovyova, Gideon J. Davies, Harry J. Gilbert, "How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity", Proceedings Of The National Academy Of Sciences (2012), DOI: 10.1073/pnas.1212034109
- Kamel El Omari, Oleg Iourin, Karl Harlos, Jonathan Grimes, Dave Stuart, "Structure of a pestivirus envelope glycoprotein E2 clarifies its role in cell entry", Cell Reports (2012), DOI: 10.1016/j.celrep.2012.12.001
- Hongjun Yu, Mingzhang Yang, Xian-En Zhang, Lijun Bi, Tao Jiang, "Crystal structures of MBOgg1 in complex with two abasic DNA ligands", Journal Of Structural Biology, 181 (3) (2012), DOI: 10.1016/j.jsb.2012.12.003
- Dengguo Wei, W. David Wilson, Stephen Neidle, "Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster", Journal Of The American Chemical Society, 135 (4) (2012), DOI: 10.1021/ja308952y
- [Thesis] Mohamed Radzi Noor, "Bioenergetics at extreme temperature: structural and functional studies of complexes II and IV of Thermus thermophilus" (2012), DOI: 10.34961/2587
- Tracey Holley, Clare Stevenson, M. Bibb, David Lawson, "High resolution crystal structure of Sco5413, a widespread actinomycete MarR family transcriptional regulator of unknown function", Proteins: Structure, Function, And Bioinformatics (2012), DOI: 10.1002/prot.24197
- Renate Gessmann, Danny Axford, Hans Brückner, Kyriacos Petratos, Gwyndaf Evans, "The crystal structure of samarosporin I at atomic resolution", Journal Of Peptide Science, 18 (11), 678 - 684 (2012), DOI: 10.1002/psc.2454
- Magdalena Wojtas, Maria Mogni, Oscar Millet, Stephen D. Bell, Nicola G. A. Abrescia, "Structural and functional analyses of the interaction of archaeal RNA polymerase with DNA", Nucleic Acids Research, 40 (19), 9941 - 9952 (2012), DOI: 10.1093/nar/gks692
- Inge Van Molle, Andreas Thomann, Dennis l. Buckley, Ernest C. So, Steffen Lang, Craig M. Crews, Alessio Ciulli, "Dissecting fragment-based lead discovery at the von Hippel-Lindau protein:hypoxia inducible factor 1α protein-protein interface", Chemistry & Biology, 19 (10), 1300 - 1312 (2012), DOI: 10.1016/j.chembiol.2012.08.015
- [Conference Paper] R. Gessmann, D. A. Axford, R. L. Owen, H. Brueckner, K. Petratos, "The crystal structure of the 14-residue peptaibol trichovirin at atomic resolution", JOURNAL OF PEPTIDE SCIENCE, 18, 109-116 (2012)
- Luke A. Yates, Sophie Fleurdépine, Olivia S. Rissland, Luigi De Colibus, Karl Harlos, Chris J. Norbury, Robert J. C. Gilbert, "Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase", Nature Structural & Molecular Biology, 19 (8), 782 - 787 (2012), DOI: 10.1038/nsmb.2329
- Danny T. Huang, Hao Dou, Lori Buetow, Gary J Sibbet, Kenneth Cameron, "BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer", Nature Structural & Molecular Biology, 19 (9), 876-883 (2012), DOI: 10.1038/nsmb.2379
- Anna Bulek, Florian Madura, Anna Fuller, Chris Holland, Andrea Schauenburg, Andrew K. Sewell, Pierre J. Rizkallah, David K. Cole, "TCR/pMHC optimized protein crystallization screen", Journal Of Immunological Methods, 382, 203 - 210 (2012), DOI: 10.1016/j.jim.2012.06.007
- A. Crow, R. K. Hughes, F. Taieb, E. Oswald, M. J. Banfield, "The molecular basis of ubiquitin-like protein NEDD8 deamidation by the bacterial effector protein Cif", Proceedings Of The National Academy Of Sciences, 109 (27), E1830 - E1838 (2012), DOI: 10.1073/pnas.1112107109
- Szymon Manka, Federico Carafoli, Robert Visse, Dominique Bihan, Nicolas Raynal, Richard W. Farndale, Gillian Murphy, Jan J. Enghild, Erhard Hohenester, Hideaki Nagase, "Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1", Proceedings Of The National Academy Of Sciences, 109 (31), 12461 - 12466 (2012), DOI: 10.1073/pnas.1204991109
- Marcus J. Edwards, Andrea Hall, Liang Shi, James K. Fredrickson, John M. Zachara, Julea N. Butt, David J. Richardson, Thomas A. Clarke, "The crystal structure of the extracellular 11-heme cytochrome UndA reveals a conserved 10-heme motif and defined binding site for soluble iron chelates", Structure, 20 (7), 1275-1284 (2012), DOI: 10.1016/j.str.2012.04.016
- Joseph A. Lyons, David Aragao, Orla Slattery, Andrei V. Pisliakov, Tewfik Soulimane, Martin Caffrey, "Structural insights into electron transfer in caa3-type cytochrome oxidase", Nature, 487, 514 - 518 (2012), DOI: 10.1038/nature11182
- Robin Owen, Danny Axford, Joanne E. Nettleship, Raymond J. Owens, James I. Robinson, Ann W. Morgan, Andrew S. Dore, Guillaume Lebon, Christopher G. Tate, Elizabeth E. Fry, Jingshan Ren, David I. Stuart, Gwyndaf Evans, "Outrunning free radicals in room-temperature macromolecular crystallography", Acta Crystallographica Section D, 68 (7), 810-818 (2012), DOI: 10.1107/S0907444912012553
- Ammar A. E. Ali, Gyula Timinszky, Raquel Arribas-Bosacoma, Marek Kozlowski, Paul O. Hassa, Markus Hassler, Andreas G. Ladurner, Laurence H. Pearl, Antony W. Oliver, "The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks", Nature Structural & Molecular Biology, 19 (7), 685 - 692 (2012), DOI: 10.1038/nsmb.2335
- George A. Penman, Deborah E. A. Lockhart, Andrew Ferenbach, Daan M. F. Van Aalten, "Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (6), 705 - 708 (2012), DOI: 10.1107/S1744309112017915
- D. Sean Froese, Tobias Krojer, Xuchu Wu, Roshi Shrestha, Wasim Kiyani, Frank Von Delft, Roy A. Gravel, Udo C. T. Oppermann, Wyatt W. Yue, "Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function", Biochemistry, 51(25), 5083-90 (2012), DOI: 10.1021/bi300150y
- Tony Warne, Patricia c. Edwards, Andrew g. W. Leslie, Christopher g. Tate, "Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol", Structure, 20 (5), 841 - 849 (2012), DOI: 10.1016/j.str.2012.03.014
- Robin L. Owen, Briony A. Yorke, Arwen R. Pearson, "X-ray-excited optical luminescence of protein crystals: a new tool for studying radiation damage during diffraction data collection", Acta Crystallographica Section D Biological Crystallography, 68 (5), 505 - 510 (2012), DOI: 10.1107/S0907444912002946
- Ilona Rissanen, Alice Pawlowski, Karl Harlos, Jonathan Grimes, David I. Stuart, Jaana K. H. Bamford, "Crystallization and preliminary crystallographic analysis of the major capsid proteins VP16 and VP17 of bacteriophage P23-77", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (5), 580 - 583 (2012), DOI: 10.1107/S1744309112010330
- Sonja Baumli, Alison Hole, Martin E. M. Noble, Jane A. Endicott, "The CDK9 C-helix exhibits conformational plasticity that may explain the selectivity of CAN508", Acs Chemical Biology, 7 (5), 811 - 816 (2012), DOI: 10.1021/cb2004516
- Anja Burkhardt, Martin Warmer, Saravanan Panneerselvam, Armin Wagner, Athina Zouni, Carina Gloeckner, Rudolph Reimer, Heinrich Hohenberg, Alke Meents, "Fast high-pressure freezing of protein crystals in their mother liquor", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (4), 495-500 (2012), DOI: 10.1107/S1744309112009670
- Richard Bayliss, Swen Hoelder, Paulo Innocent, K-M. Cheung, S. Solanki, C Mas-Droux, Fiona Rowan, S. Yeoh, K. Boxall, M. Westlake, L. Pickard, T Hardy, Joanne Baxter, G. Wynne Aherne, Andrew M. Fry, "Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: SAR, structural biology and cellular activity", Journal Of Medicinal Chemistry, 55 (7), 3228-41 (2012), DOI: 10.1021/jm201683b
- Bing Liu, James Garnett, Wei-Chao Lee, Jing Lin, Paula Salgado, Jonathan Taylor, Yingqi Xu, Sebastian Lambert, Ernesto Cota, Steve Matthews, "Promoting crystallisation of the Salmonella enteritidis fimbriae 14 pilin SefD using deuterium oxide", Biochemical And Biophysical Research Communications, 421 (2), 208 - 213 (2012), DOI: 10.1016/j.bbrc.2012.03.136
- Helen M. Kent, Philip R. Evans, Ingmar B. Schäfer, Sally R. Gray, Christopher M. Sanderson, J. paul Luzio, Andrew A. Peden, David J. Owen, "Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex", Developmental Cell, 22 (5), 979 - 988 (2012), DOI: 10.1016/j.devcel.2012.01.018
- Steven Hardwick, Tobias Gubbey, Isabelle Hug, Urs Jenal, Ben Luisi, "Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly", Open Biology, 2, 120028 - 120028 (2012), DOI: 10.1098/rsob.120028
- Rouslan G. Efremov, Leonid A. Sazanov, "Structure of Escherichia coli OmpF porin from lipidic mesophase", Journal Of Structural Biology, 178 (3), 311 - 318 (2012), DOI: 10.1016/j.jsb.2012.03.005
- Xiangxi Wang, Wei Peng, Jingshan Ren, Zhongyu Hu, Jiwei Xu, Zhiyong Lou, Xumei Li, Weidong Yin, Xinliang Shen, Claudine Porta, Thomas S. Walter, Danny Axford, Robin Owen, David J. Rowlands, Junzhi Wang, David I. Stuart, Elizabeth E. Fry, Zihe Rao, Gwyndaf Evans, "A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71", Nature Structural & Molecular Biology, 19 (4), 424 - 429 (2012), DOI: 10.1038/nsmb.2255
- Miles Congreve, Stephen P. Andrews, Andrew S. Doré, Kaspar Hollenstein, Edward Hurrell, Christopher J. Langmead, Jonathan S. Mason, Irene W. Ng, Benjamin Tehan, Andrei Zhukov, Malcolm Weir, Fiona H. Marshall, "Discovery of 1,2,4-triazine derivatives as adenosine A2A antagonists using structure based drug design", Journal Of Medicinal Chemistry, 55 (5), 1898 - 1903 (2012), DOI: 10.1021/jm201376w
- Marc De La Roche, Trevor J. Rutherford, Deepti Gupta, Dmitry B. Veprintsev, Barbara Saxty, Stefan M. Freund, Mariann Bienz, "An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid", Nature Communications, 3 (2012), DOI: 10.1038/ncomms1680
- Tomoya Hino, Takatoshi Arakawa, Hiroko Iwanari, Takami Yurugi-Kobayashi, Chiyo Ikeda-Suno, Yoshiko Nakada-Nakura, Osamu Kusano-Arai, Simone Weyand, Tatsuro Shimamura, Norimichi Nomura, Alexander D. Cameron, Takuya Kobayashi, Takao Hamakubo, So Iwata, Takeshi Murata, "G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody", Nature, 482, 237–240 (2012), DOI: 10.1038/nature10750
- Thibaud Perriches, Martin R. Singleton, "Structure of yeast kinetochore Ndc10 DNA-binding domain reveals unexpected evolutionary relationship to tyrosine recombinases", Journal Of Biological Chemistry, 287 (7), 5173 - 5179 (2012), DOI: 10.1074/jbc.C111.318501
- Renate Gessmann, Danny Axford, Robin Owen, Hans Brückner, Kyriacos Petratos, "Four complete turns of a curved 3 10-helix at atomic resolution: the crystal structure of the peptaibol trichovirin I-4A in a polar environment suggests a transition to [alpha]-helix for membrane function", Acta Crystallographica Section D Biological Crystallography, 68 (2), 109 - 116 (2012), DOI: 10.1107/S090744491105133X
- Muhammad Saleem, Stephen M. Prince, Hema Patel, Hannah Chan, Ian M. Feavers, Jeremy P. Derrick, "Refolding, purification and crystallization of the FrpB outer membrane iron transporter from Neisseria meningitidis", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (2), 231 - 235 (2012), DOI: 10.1107/S1744309111056028
- Peter J. Watson, Louise Fairall, Guilherme M. Santos, John W. R. Schwabe, "Structure of HDAC3 bound to corepressor and inositol tetraphosphate", Nature (2012), DOI: 10.1038/nature10728
- Vassiliy N. Bavro, Rita De Zorzi, Matthias R. Schmidt, Joao R. C. Muniz, Lejla Zubcevic, Mark S. P. Sansom, Catherine Venien-Bryan, Stephen J. Tucker, "Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating", Nature Structural & Molecular Biology (2012), DOI: 10.1038/nsmb.2208
- Anna Bulek, David Cole, Ania Skowera, Garry Dolton, Stephanie Gras, Florian Madura, Anna Fuller, John Miles, Emma Gostick, David A. Price, Jan W. Drijfhout, Robin R. Knight, Guo C. Huang, Nikolai Lissin, Peter E. Molloy, Linda Fothergill-Gilmore, Bent K. Jakobsen, Jamie Rossjohn, Mark Peakman, Pierre J. Rizkallah, Andrew K. Sewell, "Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes", Nature Immunology (2012), DOI: 10.1038/ni.2206
- Andrew Thompson, Rohan J. Williams, Zalihe Hakki, Dominic S. Alonzi, Tom Wennekes, Tracey Gloster, Kriangsak Songsrirote, Jane E. Thomas-Oates, Tanja M. Wrodnigg, Josef Spreitz, Arnold E. Stutz, Terry D. Butters, Spencer J. Williams, Gideon J. Davies, "Structural and mechanistic insight into N-glycan processing by endo- -mannosidase", Proceedings Of The National Academy Of Sciences (2012), DOI: 10.1073/pnas.1111482109
- Gavin W. Collie, Rossella Promontorio, Sonja M. Hampel, Marialuisa Micco, Stephen Neidle, Gary N. Parkinson, "Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands", Journal Of The American Chemical Society, 134 (5) (2012), DOI: 10.1021/ja2102423
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