Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
87 items found for 2015 [total: 1243]
Redox signaling by the rna polymerase III TFIIB-related factor Brf2 Cell, 163 (6) Dec 2015 DOI: 10.1016/j.cell.2015.11.005
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue Nucleic Acids Research, Dec 2015 DOI: 10.1093/nar/gkv1369
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist Science, 350 Dec 2015 DOI: 10.1126/science.aac5464
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology- mediated end-joining pathway Structure, 23 (12) Dec 2015 DOI: 10.1016/j.str.2015.10.014
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
The first N-terminal unprotected (Gly-Aib)n peptide: H-Gly-Aib-Gly-Aib-OtBu Acta Crystallographica Section C Structural Chemistry, 71 (12) Dec 2015 DOI: 10.1107/S2053229615022597
Journal Paper I24-Microfocus Macromolecular Crystallography
Crystal structure of the Z-ring associated cell division protein ZapC from Escherichia coli Febs Letters, 589 (24) Part B Dec 2015 DOI: 10.1016/j.febslet.2015.11.030
Crystal structure of a eukaryotic GEN1 resolving enzyme bound to DNA Cell Reports, 13 Dec 2015 DOI: 10.1016/j.celrep.2015.11.042
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Ternary structure reveals mechanism of a membrane diacylglycerol kinase Nature Communications, 6 Dec 2015 DOI: 10.1038/ncomms10140
Application of in situ diffraction in high-throughput structure determination platforms Methods In Molecular Biology, 1261 Nov 2015 DOI: 10.1007/978-1-4939-2230-7_13
Book Chapter I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
X-ray structure and activities of an essential Mononegavirales L-protein domain Nature Communications, 6 Nov 2015 DOI: 10.1038/ncomms9749
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 Nature Communications, 6 Nov 2015 DOI: 10.1038/ncomms9681
Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding Scientific Reports, 5 Nov 2015 DOI: 10.1038/srep17122
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Natural products: biosynthesis, antimicrobial properties and protein targets Nov 2015
Thesis I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism Scientific Reports, 5 Nov 2015 DOI: 10.1038/srep17144
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities Nucleic Acids Research, Nov 2015 DOI: 10.1093/nar/gkv1256
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Development of crystallographic techniques and their application to several protein targets Nov 2015
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Calcium-induced conformational changes in the regulatory domain of the human mitochondrial ATP-Mg/Pi carrier Biochimica Et Biophysica Acta (bba) - Bioenergetics, 1847 (10) Oct 2015 DOI: 10.1016/j.bbabio.2015.07.002
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain Journal Of Molecular Biology, 427 (20) Oct 2015 DOI: 10.1016/j.jmb.2015.08.023
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of the conserved amino-terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody Journal Of Virology, Oct 2015 DOI: 10.1128/JVI.02105-15
Journal Paper I24-Microfocus Macromolecular Crystallography
Pharmacological analysis and structure determination of 7-methylcyanopindolol–bound β1-adrenergic receptor Molecular Pharmacology, 88 (6) Oct 2015 DOI: 10.1124/mol.115.101030
Journal Paper I24-Microfocus Macromolecular Crystallography
High-resolution atomic force microscopy Oct 2015
Poster I24-Microfocus Macromolecular Crystallography
Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport Structure, 23 (10) Oct 2015 DOI: 10.1016/j.str.2015.07.016
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural, biophysical and functional characterization of Nop7-Erb1-Ytm1 complex and its implications in eukaryotic ribosome biogenesis Oct 2015 DOI: 10.4995/Thesis/10251/55941
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes Science, 350 Oct 2015 DOI: 10.1126/science.aac7365
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure of a PEGylated protein reveals a highly porous double-helical assembly Nature Chemistry, 7 (10) Sept 2015 DOI: 10.1038/nchem.2342
Journal Paper I24-Microfocus Macromolecular Crystallography
Structures of the methyltransferase component of Desulfitobacterium hafniense DCB-2 O-demethylase shed light on methyltetrahydrofolate formation Acta Crystallographica Section D Biological Crystallography, 71 Sept 2015 DOI: 10.1107/S1399004715013061
Fixed target matrix for femtosecond time-resolved and in situ serial micro-crystallography Structural Dynamics, 2 Sept 2015 DOI: 10.1063/1.4928706
Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design Nature Structural & Molecular Biology, Sept 2015 DOI: 10.1038/nsmb.3096
Journal Paper I24-Microfocus Macromolecular Crystallography
Structures of coxsackievirus A16 capsids with native antigenicity: implications for particle expansion, receptor binding, and immunogenicity Journal Of Virology, 89 (20) Sept 2015 DOI: 10.1128/JVI.01102-15
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of a novel two domain GH78 family α-rhamnosidase from Proteins: Structure, Function, And Bioinformatics, 83 (9) Sept 2015 DOI: 10.1002/prot.24807
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Crystal structures of a double-barrelled fluoride ion channel Nature, 525 (7570) Sept 2015 DOI: 10.1038/nature14981
Type II inhibitors targeting CDK2 Acs Chemical Biology, 10 (9) Sept 2015 DOI: 10.1021/acschembio.5b00398
Journal Paper I24-Microfocus Macromolecular Crystallography
Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors Medchemcomm, 6 (9) Sept 2015 DOI: 10.1039/C5MD00210A
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure of subcomplex Iβ of mammalian respiratory complex I leads to new supernumerary subunit assignments Proceedings Of The National Academy Of Sciences, 112 Sept 2015 DOI: 10.1073/pnas.1510577112
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug resistance Cancer Research, 75 (16) Aug 2015 DOI: 10.1158/0008-5472.CAN-14-3272
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A new high-resolution crystal structure of the Drosophila melanogaster angiotensin converting enzyme homologue, AnCE Febs Open Bio, 5 Aug 2015 DOI: 10.1016/j.fob.2015.08.004
Polyhedra structures and the evolution of the insect viruses Journal Of Structural Biology, Aug 2015 DOI: 10.1016/j.jsb.2015.08.009
A four-helix bundle stores copper for methane oxidation Nature, 525 (7567) Aug 2015 DOI: 10.1038/nature14854
Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase Medchemcomm, Aug 2015 DOI: 10.1039/C5MD00242G
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural analysis of leader peptide binding enables leader-free cyanobactin processing Nature Chemical Biology, 11 (8) Aug 2015 DOI: 10.1038/nchembio.1841
Fragment and structure-based drug discovery for a class C GPCR: discovery of the mGlu5 negative allosteric modulator HTL14242 (3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile) Journal Of Medicinal Chemistry, 58 (16) Aug 2015 DOI: 10.1021/acs.jmedchem.5b00892
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural and adhesive properties of the long polar fimbriae protein LpfD from adherent-invasive Escherichia coli Acta Crystallographica Section D Biological Crystallography, 71 Aug 2015 DOI: 10.1107/S1399004715009803
Journal Paper I24-Microfocus Macromolecular Crystallography
The structure of Na+-translocating of NADH:ubiquinone oxidoreductase of Vibrio cholerae: implications on coupling between electron transfer and Na+ transport Biological Chemistry, 396 (9-10) Jul 2015 DOI: 10.1515/hsz-2015-0128
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation Nature Communications, 6 Jul 2015 DOI: 10.1038/ncomms8542
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structures reveal that the reaction mechanism of imidazoleglycerol-phosphate dehydratase is controlled by switching Mn(II) coordination Structure, 23 (7) Jul 2015 DOI: 10.1016/j.str.2015.05.012
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan Elife, 4 Jul 2015 DOI: 10.7554/eLife.06554
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural characterization of the principal mRNA-export factor Mex67–Mtr2 from Chaetomium thermophilum Acta Crystallographica Section F Structural Biology Communications, 71 (7) Jul 2015 DOI: 10.1107/S2053230X15008766
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of protease-cleaved Escherichia coli alpha-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment Acta Crystallographica Section D Biological Crystallography, 71 (7) Jul 2015 DOI: 10.1107/S1399004715008548
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone Chemical Communications, 51 (52) Jul 2015 DOI: 10.1039/C5CC01816A
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure determination of an integral membrane protein at room temperature from crystals in situ Acta Crystallographica Section D Biological Crystallography, 71 June 2015 DOI: 10.1107/S139900471500423X
The Cryo-EM structure of the CorA channel from Methanocaldococcus jannaschii in low magnesium conditions Biochimica Et Biophysica Acta (bba) - Biomembranes, June 2015 DOI: 10.1016/j.bbamem.2015.06.002
Journal Paper I22-Small angle scattering & Diffraction I24-Microfocus Macromolecular Crystallography open access
The automation of protein crystal presentation for X-ray diffraction experiments using standing acoustic waves in a microfluidic chip environment June 2015
Conference Paper I24-Microfocus Macromolecular Crystallography open access
Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major Molecular And Biochemical Parasitology, May 2015 DOI: 10.1016/j.molbiopara.2015.05.003
Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases Proceedings Of The National Academy Of Sciences, 112 (19) May 2015 DOI: 10.1073/pnas.1500161112
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural and kinetic characterization of thymidine kinase from Leishmania major Plos Neglected Tropical Diseases, 9 (5) May 2015 DOI: 10.1371/journal.pntd.0003781
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Hidden photoinduced reactivity of the blue fluorescent protein mKalama1 Physical Chemistry Chemical Physics, 17 (19) May 2015 DOI: 10.1039/C5CP00887E
Journal Paper I24-Microfocus Macromolecular Crystallography
LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor Angewandte Chemie International Edition, 54 (21) May 2015 DOI: 10.1002/anie.201501394
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Against the odds? De novo structure determination of a pilin with two cysteine residues by sulfur SAD Acta Crystallographica Section D Biological Crystallography, 71 (5) May 2015 DOI: 10.1107/S1399004715003272
Journal Paper I24-Microfocus Macromolecular Crystallography
A micro-patterned silicon chip as sample holder for macromolecular crystallography experiments with minimal background scattering Scientific Reports, 5 May 2015 DOI: 10.1038/srep10451
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of K29 polyubiquitin Molecular Cell, 58 (1) Apr 2015 DOI: 10.1016/j.molcel.2015.01.041
Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization Nature Communications, 6 Apr 2015 DOI: 10.1038/ncomms7718
Selective targeting of the TPX2 site of importin-α using fragment-based ligand design Chemmedchem, Apr 2015 DOI: 10.1002/cmdc.201500014
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans: A cytosolic enzyme with a di-nuclear active site Febs Open Bio, 5 Apr 2015 DOI: 10.1016/j.fob.2015.03.013
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes Nucleic Acids Research, Apr 2015 DOI: 10.1093/nar/gkv373
Structures of the Ets protein DNA-binding domains of transcription factors Etv1, Etv4, Etv5, and Fev: determinants of DNA binding and redox regulation by disulfide bond formation Journal Of Biological Chemistry, Apr 2015 DOI: 10.1074/jbc.M115.646737
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The carboxy-terminal domain of Erb1 is a seven-bladed ß-propeller that binds RNA Plos One, 10 Apr 2015 DOI: 10.1371/journal.pone.0123463
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch Elife, 4 Apr 2015 DOI: 10.7554/eLife.06421
Crystal structures of the human adiponectin receptors Nature, 520 Apr 2015 DOI: 10.1038/nature14301
Journal Paper I24-Microfocus Macromolecular Crystallography
Resolution of key roles for the distal pocket histidine in cytochrome c nitrite reductases Journal Of The American Chemical Society, 137 (8) Mar 2015 DOI: 10.1021/ja512941j
Assembly and specific recognition of K29- and K33-linked polyubiquitin Molecular Cell, Mar 2015 DOI: 10.1016/j.molcel.2015.01.042
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
High-resolution crystal structure of a polyextreme GH43 glycosidase from Halothermothrix orenii with alpha-L-arabinofuranosidase activity Acta Crystallographica Section F Structural Biology Communications, 71 Mar 2015 DOI: 10.1107/S2053230X15003337
The effect of mutations on drug sensitivity and kinase activity of fibroblast growth factor receptors: a combined experimental and theoretical study Ebiomedicine, 2 (3) Mar 2015 DOI: 10.1016/j.ebiom.2015.02.009
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Dimerization of matrix protein is required for budding of respiratory syncytial virus Journal Of Virology, 89 (8) Mar 2015 DOI: 10.1128/JVI.03500-14
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac Science, 347 (6227) Mar 2015 DOI: 10.1126/science.1261512
Improved crystallization and diffraction of caffeine-induced death suppressor protein 1 (Cid1) Acta Crystallographica Section F Structural Biology Communications, 71 (3) Mar 2015 DOI: 10.1107/S2053230X15001351
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Activation of a primed RING E3-E2–ubiquitin complex by non-covalent ubiquitin Molecular Cell, 58 Mar 2015 DOI: 10.1016/j.molcel.2015.02.017
GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014 Naunyn-Schmiedeberg'S Archives Of Pharmacology, Mar 2015 DOI: 10.1007/s00210-015-1111-8
Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data Nature Communications, 6 Mar 2015 DOI: 10.1038/ncomms7435
The crystal structure of the human titin: obscurin complex reveals a conserved yet specific muscle M-band zipper module Journal Of Molecular Biology, 427 (4) Feb 2015 DOI: 10.1016/j.jmb.2014.11.019
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The role of monovalent cations in the ATPase reaction of DNA gyrase Acta Crystallographica Section D, 71 Feb 2015 DOI: 10.1107/S1399004715002916
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Notum deacylates Wnt proteins to suppress signalling activity Nature, 519 (7542) Feb 2015 DOI: 10.1038/nature14259
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystallization and preliminary crystallographic analysis of the putative sugar-binding protein Msmeg_0515 (AgaE) from Acta Crystallographica Section F Structural Biology Communications, 71 Feb 2015 DOI: 10.1107/S2053230X15000035
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Gating topology of the proton-coupled oligopeptide symporters Structure, 23 (2) Feb 2015 DOI: 10.1016/j.str.2014.12.012
Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2 Journal Of Structural And Functional Genomics, Jan 2015 DOI: 10.1007/s10969-014-9192-z
Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC Structure, 23 (1) Jan 2015 DOI: 10.1016/j.str.2014.10.017
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis Angiogenesis, 18 (2) Jan 2015 DOI: 10.1007/s10456-014-9457-y
Experimental phasing for structure determination using membrane-protein crystals grown by the lipid cubic phase method Acta Crystallographica Section D Biological Crystallography, 71 Jan 2015 DOI: 10.1107/S1399004714010360
- Jerome Gouge, Karishma Satia, Nicolas Guthertz, Marcella Widya, Andrew james Thompson, Pascal Cousin, Oleksandr Dergai, Nouria Hernandez, Alessandro Vannini, "Redox signaling by the rna polymerase III TFIIB-related factor Brf2", Cell, 163 (6), 1375 - 1387 (2015), DOI: 10.1016/j.cell.2015.11.005
- Bart Van Laer, Martine Roovers, Lina Wauters, Joanna M. Kasprzak, Michal Dyzma, Egon Deyaert, Ranjan Kumar singh, André Feller, Janusz M. Bujnicki, Louis Droogmans, Wim Versees, "Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue", Nucleic Acids Research (2015), DOI: 10.1093/nar/gkv1369
- S. Ahuja, S. Mukund, L. Deng, K. Khakh, E. Chang, H. Ho, S. Shriver, C. Young, S. Lin, J. P. Johnson, P. Wu, J. Li, M. Coons, C. Tam, B. Brillantes, H. Sampang, K. Mortara, K. K. Bowman, K. R. Clark, A. Estevez, "Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist", Science, 350, aac5464 - aac5464 (2015), DOI: 10.1126/science.aac5464
- Joseph A. Newman, Christopher D. O. Cooper, Hazel Aitkenhead, Opher Gileadi, "Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology- mediated end-joining pathway", Structure, 23 (12), 2319 - 2330 (2015), DOI: 10.1016/j.str.2015.10.014
- Renate Gessmann, Hans Brückner, Kyriacos Petratos, "The first N-terminal unprotected (Gly-Aib)n peptide: H-Gly-Aib-Gly-Aib-OtBu", Acta Crystallographica Section C Structural Chemistry, 71 (12), 1114 - 1117 (2015), DOI: 10.1107/S2053229615022597
- Cristina Ortiz, Danguole Kureisaite-Ciziene, Florian Schmitz, Stephen H. Mclaughlin, Miguel Vicente, Jan Löwe, "Crystal structure of the Z-ring associated cell division protein ZapC from Escherichia coli", Febs Letters, 589 (24) Part B, 3822 - 3828 (2015), DOI: 10.1016/j.febslet.2015.11.030
- Yijin Liu, Alasdair d J Freeman, Anne-Cécile Déclais, Timothy j Wilson, Anton Gartner, David Lilley, "Crystal structure of a eukaryotic GEN1 resolving enzyme bound to DNA", Cell Reports, 13, 2565 - 2575 (2015), DOI: 10.1016/j.celrep.2015.11.042
- Dianfan Li, Phillip J. Stansfeld, Mark S. P. Sansom, Aaron Keogh, Lutz Vogeley, Nicole Howe, Joseph Lyons, David Aragao, Petra Fromme, Raimund Fromme, Shibom Basu, Ingo Grotjohann, Christopher Kupitz, Kimberley Rendek, Uwe Weierstall, Nadia A. Zatsepin, Vadim Cherezov, Wei Liu, Sateesh Bandaru, Niall J. English, Cornelius Gati, Anton Barty, Oleksandr Yefanov, Henry N. Chapman, Kay Diederichs, Marc Messerschmidt, Sébastien Boutet, Garth J. Williams, M. Marvin Seibert, Martin Caffrey, "Ternary structure reveals mechanism of a membrane diacylglycerol kinase", Nature Communications, 6 (2015), DOI: 10.1038/ncomms10140
- [Book Chapter] Raymond J. Owens, Pierre Aller, Juan Sanchez-Weatherby, James Foadi, Graeme Winter, Carina Lobley, Danny Axford, Alun Ashton, Domenico Bellini, Jose Brandao-Neto, Simone Culurgioni, Alice Douangamath, Ramona Duman, Gwyndaf Evans, Stuart Fisher, Ralf Flaig, Dave Hall, Petra Lukacik, Marco Mazzorana, Katherine Mcauley, "Application of in situ diffraction in high-throughput structure determination platforms", Methods In Molecular Biology, 1261, 233-253 (2015), DOI: 10.1007/978-1-4939-2230-7_13
- Guido C. Paesen, Axelle Collet, Corinne Sallamand, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard, Etienne Decroly, Jonathan M Grimes, "X-ray structure and activities of an essential Mononegavirales L-protein domain", Nature Communications, 6 (2015), DOI: 10.1038/ncomms9749
- Yohendran Baskaran, Khay C. Ang, Praju V. Anekal, Wee L. Chan, Jonathan M Grimes, Ed Manser, Robert C. Robinson, "An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1", Nature Communications, 6 (2015), DOI: 10.1038/ncomms9681
- Sarah E Dixon-Clarke, Jonathan M. Elkins, S.-W. Grace Cheng, Gregg B. Morin, Alex N. Bullock, "Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding", Scientific Reports, 5 (2015), DOI: 10.1038/srep17122
- [Thesis] Daynea Wallock-Richards, "Natural products: biosynthesis, antimicrobial properties and protein targets" (2015)
- Vitor Mendes, Michal Blaszczyk, Ana Maranha, Nuno Empadinhas, Tom L. Blundell, "Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism", Scientific Reports, 5 (2015), DOI: 10.1038/srep17144
- C. K. Allerston, S. Y. Lee, J. A. Newman, C. J. Schofield, P. J. Mchugh, O. Gileadi, "The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities", Nucleic Acids Research (2015), DOI: 10.1093/nar/gkv1256
- [Thesis] Sam Horrell, "Development of crystallographic techniques and their application to several protein targets" (2015)
- Steven Harborne, Jonathan Ruprecht, Edmund Kunji, "Calcium-induced conformational changes in the regulatory domain of the human mitochondrial ATP-Mg/Pi carrier", Biochimica Et Biophysica Acta (bba) - Bioenergetics, 1847 (10), 1245 - 1253 (2015), DOI: 10.1016/j.bbabio.2015.07.002
- Nora Cronin, Jing Yang, Ziguo Zhang, Kiran Kulkarni, Leifu Chang, Hiroyuki Yamano, David Barford, "Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain", Journal Of Molecular Biology, 427 (20) (2015), DOI: 10.1016/j.jmb.2015.08.023
- Ki Joon Cho, Bert Schepens, Kristof Moonens, Lei Deng, Walter Fiers, Han Remaut, Xavier Saelens, "Crystal structure of the conserved amino-terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody", Journal Of Virology (2015), DOI: 10.1128/JVI.02105-15
- T. Sato, J. Baker, Tony Warne, G. A. Brown, Andrew Leslie, M. Congreve, Chris Tate, "Pharmacological analysis and structure determination of 7-methylcyanopindolol–bound β1-adrenergic receptor", Molecular Pharmacology, 88 (6), 1024 - 1034 (2015), DOI: 10.1124/mol.115.101030
- [Poster] G. M. Lazzerini, G Paterno, F Cacialli, "High-resolution atomic force microscopy" (2015)
- John Beale, Joanne Parker, Firdaus Samsudin, Anne l. Barrett, Anish Senan, Louise Bird, David Scott, Raymond Owens, Mark S. P Sansom, Stephen Tucker, David Meredith, Philip W. Fowler, Simon Newstead, "Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport", Structure, 23 (10), 1–11 (2015), DOI: 10.1016/j.str.2015.07.016
- [Thesis] Marcin Wegrecki, "Structural, biophysical and functional characterization of Nop7-Erb1-Ytm1 complex and its implications in eukaryotic ribosome biogenesis" (2015), DOI: 10.4995/Thesis/10251/55941
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- Hanno Sjuts, Mark Dunstan, Karl Fisher, David Leys, "Structures of the methyltransferase component of Desulfitobacterium hafniense DCB-2 O-demethylase shed light on methyltetrahydrofolate formation", Acta Crystallographica Section D Biological Crystallography, 71, 1900 - 1908 (2015), DOI: 10.1107/S1399004715013061
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- Shintaro Aibara, Eugene Valkov, Meindert Lamers, Lyudmila Dimitrova, Ed Hurt, Murray Stewart, "Structural characterization of the principal mRNA-export factor Mex67–Mtr2 from Chaetomium thermophilum", Acta Crystallographica Section F Structural Biology Communications, 71 (7), 876 - 888 (2015), DOI: 10.1107/S2053230X15008766
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- Daynea J. Wallock-Richards, Jon Marles-Wright, David J. Clarke, Amarnath Maitra, Michael Dodds, Bryan Hanley, Dominic J. Campopiano, "Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone", Chemical Communications, 51 (52), 10483 - 10485 (2015), DOI: 10.1039/C5CC01816A
- Danny Axford, James Foadi, Nien-Jen Hu, Hassan Choudhury, So Iwata, Konstantinos Beis, Gwyndaf Evans, Yilmaz Alguel, "Structure determination of an integral membrane protein at room temperature from crystals in situ", Acta Crystallographica Section D Biological Crystallography, 71 (2015), DOI: 10.1107/S139900471500423X
- Robert Cleverley, James Kean, Chitra Shintre, Clair Baldock, Jeremy Derrick, Robert C. Ford, Stephen Prince, "The Cryo-EM structure of the CorA channel from Methanocaldococcus jannaschii in low magnesium conditions", Biochimica Et Biophysica Acta (bba) - Biomembranes (2015), DOI: 10.1016/j.bbamem.2015.06.002
- [Conference Paper] Christian Burton, Mark Prince, Rob Morris, Mile Trent, Peter Docker, James Kay, David Stuart, Gwyndaf Evans, "The automation of protein crystal presentation for X-ray diffraction experiments using standing acoustic waves in a microfluidic chip environment" (2015)
- Keri Barrack, Paul Fyfe, Alex J. Finney, William Hunter, "Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major", Molecular And Biochemical Parasitology (2015), DOI: 10.1016/j.molbiopara.2015.05.003
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- Christopher Cooper, Joseph A Newman, Hazel Aitkenhead, Charles K. Allerston, Opher Gileadi, "Structures of the Ets protein DNA-binding domains of transcription factors Etv1, Etv4, Etv5, and Fev: determinants of DNA binding and redox regulation by disulfide bond formation", Journal Of Biological Chemistry (2015), DOI: 10.1074/jbc.M115.646737
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- Colin Lockwood, Bénédicte Burlat, Myles R. Cheesman, Melanie Kern, Jörg Simon, Tom Clarke, David J. Richardson, Julea N. Butt, "Resolution of key roles for the distal pocket histidine in cytochrome c nitrite reductases", Journal Of The American Chemical Society, 137 (8), 3059 - 3068 (2015), DOI: 10.1021/ja512941j
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