Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
76 items found for 2017 [total: 1243]
Target identification and mode of action of four chemically divergent drugs against Ebola virus infection Journal Of Medicinal Chemistry, Dec 2017 DOI: 10.1021/acs.jmedchem.7b01249
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides Nature Microbiology, 344 Dec 2017 DOI: 10.1038/s41564-017-0079-1
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
A rapidly-reversible absorptive and emissive vapochromic Pt(II) pincer-based chemical sensor Nature Communications, 8 Dec 2017 DOI: 10.1038/s41467-017-01941-2
Molecular basis of AKAP79 regulation by calmodulin Nature Communications, 8 Nov 2017 DOI: 10.1038/s41467-017-01715-w
Porphyrin-assisted docking of a thermophage portal protein into lipid bilayers: nanopore engineering and characterization Acs Nano, Nov 2017 DOI: 10.1021/acsnano.7b06980
Journal Paper I24-Microfocus Macromolecular Crystallography
The molecular basis of phosphite and hypophosphite recognition by ABC-transporters Nature Communications, 8 Nov 2017 DOI: 10.1038/s41467-017-01226-8
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The molecular mechanism of substrate recognition and catalysis of the membrane acyltransferase PatA from mycobacteria Acs Chemical Biology, Nov 2017 DOI: 10.1021/acschembio.7b00578
Journal Paper I24-Microfocus Macromolecular Crystallography
An acoustic on-chip goniometer for room temperature macromolecular crystallography Lab On A Chip, Nov 2017 DOI: 10.1039/C7LC00812K
Journal Paper I24-Microfocus Macromolecular Crystallography
Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope Frontiers In Immunology, 8 Nov 2017 DOI: 10.3389/fimmu.2017.01503
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily Proceedings Of The National Academy Of Sciences, 23 Nov 2017 DOI: 10.1073/pnas.1712153114
Crystal structure of NucB, a biofilm-degrading endonuclease Nucleic Acids Research, Nov 2017 DOI: 10.1093/nar/gkx1170
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The structure of a conserved domain of TamB reveals a hydrophobic β taco fold Structure, Nov 2017 DOI: 10.1016/j.str.2017.10.002
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structural basis of nucleotide sugar transport across the Golgi membrane Nature, 343 Nov 2017 DOI: 10.1038/nature24464
Journal Paper I24-Microfocus Macromolecular Crystallography
Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi Plos One, 12 Nov 2017 DOI: 10.1371/journal.pone.0188127
Proton movement and coupling in the POT family of peptide transporters Proceedings Of The National Academy Of Sciences, 63 Nov 2017 DOI: 10.1073/pnas.1710727114
Modelling the free energy profile of the mitochondrial ADP/ATP carrier Biochimica Et Biophysica Acta (bba) - Bioenergetics, 1858 Nov 2017 DOI: 10.1016/j.bbabio.2017.05.006
AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation Elife, 6 Oct 2017 DOI: 10.7554/eLife.29428
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Disulfide bond formation protects Arabidopsis thaliana glutathione transferase tau 23 from oxidative damage Biochimica Et Biophysica Acta (bba) - General Subjects, Oct 2017 DOI: 10.1016/j.bbagen.2017.10.007
Structural basis for maintenance of bacterial outer membrane lipid asymmetry Nature Microbiology, 70 Oct 2017 DOI: 10.1038/s41564-017-0046-x
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Protein dynamics promote hydride tunnelling in substrate oxidation by aryl-alcohol oxidase Physical Chemistry Chemical Physics, 19 Oct 2017 DOI: 10.1039/C7CP05904C
Journal Paper I24-Microfocus Macromolecular Crystallography
Compact and portable X-ray imager system using Medipix3RX Journal Of Instrumentation, 12 Oct 2017 DOI: 10.1088/1748-0221/12/10/C10011
Conference Paper I19-Small Molecule Single Crystal Diffraction I24-Microfocus Macromolecular Crystallography
Decoding corticotropin-releasing factor receptor type 1 crystal structures Current Molecular Pharmacology, 10 Oct 2017 DOI: 10.2174/1874467210666170110114727
Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes Scientific Reports, 7 Oct 2017 DOI: 10.1038/s41598-017-13990-0
Structure of PINK1 in complex with its substrate ubiquitin Nature, Oct 2017 DOI: 10.1038/nature24645
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center Nature Communications, 8 Oct 2017 DOI: 10.1038/s41467-017-00886-w
Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites Nature Structural & Molecular Biology, 22 Oct 2017 DOI: 10.1038/nsmb.3477
Mechanism and regulation of the Lys6-selective deubiquitinase USP30 Nature Structural & Molecular Biology, Sept 2017 DOI: 10.1038/nsmb.3475
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structural snapshots of α-1,3-galactosyltransferase with native substrates: insight into the catalytic mechanism of retaining glycosyltransferases Angewandte Chemie International Edition, Sept 2017 DOI: 10.1002/anie.201707922
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Relaxation of nonproductive binding and increased rate of coenzyme release in an alcohol dehydrogenase increases turnover with a non-preferred alcohol enantiomer The Febs Journal, Sept 2017 DOI: 10.1111/febs.14279
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Stereotyped antibody responses target posttranslationally modified gluten in celiac disease Jci Insight, 2 Sept 2017 DOI: 10.1172/jci.insight.93961
Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors Biochimica Et Biophysica Acta (bba) - General Subjects, Sept 2017 DOI: 10.1016/j.bbagen.2017.09.012
Journal Paper I24-Microfocus Macromolecular Crystallography
A novel approach to data collection for difficult structures: data management for large numbers of crystals with the BLEND software Crystals, 7 Aug 2017 DOI: 10.3390/cryst7080242
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural mechanism for modulation of synaptic neuroligin-neurexin signaling by MDGA proteins Neuron, 95 Aug 2017 DOI: 10.1016/j.neuron.2017.07.040
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Adenosine monophosphate binding stabilizes the KTN domain of the Shewanella denitrificans kef potassium efflux system Biochemistry, 56 Aug 2017 DOI: 10.1021/acs.biochem.7b00300
Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer Elife, 6 Aug 2017 DOI: 10.7554/eLife.26487
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural characterization of acidic M17 leucine aminopeptidases from the TriTryps and evaluation of their role in nutrient starvation in Trypanosoma brucei Msphere, 2 Aug 2017 DOI: 10.1128/mSphere.00226-17
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The function and biogenesis of the clostridium difficile S-layer Aug 2017
Thesis I24-Microfocus Macromolecular Crystallography
The cubicon method for concentrating membrane proteins in the cubic mesophase Nature Protocols, 12 Aug 2017 DOI: 10.1038/nprot.2017.057
Frutapin, a lectin from Artocarpus incisa (breadfruit): cloning, expression and molecular insights Bioscience Reports, Jul 2017 DOI: 10.1042/BSR20170969
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses Nature Communications, 8 Jul 2017 DOI: 10.1038/ncomms16060
Structures of human A1 and A2A adenosine receptors with xanthines reveal determinants of selectivity Structure, Jul 2017 DOI: 10.1016/j.str.2017.06.012
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis Nature Communications, 8 Jul 2017 DOI: 10.1038/ncomms15952
NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin Scientific Reports, 7 Jul 2017 DOI: 10.1038/s41598-017-05325-w
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Beating the sugar rush Jul 2017
Science Highlight I24-Microfocus Macromolecular Crystallography
Structural biology and the design of new therapeutics: from HIV and cancer to mycobacterial infections Journal Of Molecular Biology, June 2017 DOI: 10.1016/j.jmb.2017.06.014
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2 Journal Of Biological Chemistry, June 2017 DOI: 10.1074/jbc.M117.788992
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Serial Synchrotron X-Ray Crystallography (SSX) Null, June 2017 DOI: 10.1007/978-1-4939-7000-1_10
Book Chapter I24-Microfocus Macromolecular Crystallography
Structural basis for specific interaction of TGFβ signaling regulators SARA/Endofin with HD-PTP Structure, June 2017 DOI: 10.1016/j.str.2017.05.005
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity Nature Structural & Molecular Biology, 62 May 2017 DOI: 10.1038/nsmb.3414
Journal Paper I24-Microfocus Macromolecular Crystallography
Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus Nature Communications, 8 May 2017 DOI: 10.1038/ncomms15408
The structure of the guanidine-II riboswitch Cell Chemical Biology, May 2017 DOI: 10.1016/j.chembiol.2017.05.014
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Identification and characterization of a heterotrimeric archaeal DNA polymerase holoenzyme Nature Communications, 8 May 2017 DOI: 10.1038/ncomms15075
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Nanoscale characterisation and neutron damage testing of organic semiconductors May 2017
Thesis I24-Microfocus Macromolecular Crystallography open access
Crystal structure of the GLP-1 receptor bound to a peptide agonist Nature, 546 May 2017 DOI: 10.1038/nature22800
Journal Paper I24-Microfocus Macromolecular Crystallography
Low-dose fixed-target serial synchrotron crystallography Acta Crystallographica Section D Structural Biology, 73 Apr 2017 DOI: 10.1107/S2059798317002996
Structural insight into allosteric modulation of protease-activated receptor 2 Nature, 545 Apr 2017 DOI: 10.1038/nature22309
Journal Paper I24-Microfocus Macromolecular Crystallography
Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach British Journal Of Pharmacology, Apr 2017 DOI: 10.1111/bph.13810
Structural insights into the ene-reductase synthesis of profens Organic & Biomolecular Chemistry, Apr 2017 DOI: 10.1039/C7OB00163K
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and functional insight into human O-GlcNAcase Nature Chemical Biology, 258 Mar 2017 DOI: 10.1038/nchembio.2358
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Catalytic determinants of alkene production by the cytochrome P450 peroxygenase OleTJE Journal Of Biological Chemistry, 292 Mar 2017 DOI: 10.1074/jbc.M116.762336
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Complex pectin metabolism by gut bacteria reveals novel catalytic functions Nature, 411 Mar 2017 DOI: 10.1038/nature21725
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structure determination of a major facilitator peptide transporter: Inward facing PepTSt from Streptococcus thermophilus crystallized in space group P3121 Plos One, 12 Mar 2017 DOI: 10.1371/journal.pone.0173126
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
19F-NMR reveals the role of mobile loops in product and inhibitor binding by the São Paulo metallo-β-lactamase Angewandte Chemie International Edition, 5 Mar 2017 DOI: 10.1002/anie.201612185
An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump Elife, 6 Mar 2017 DOI: 10.7554/eLife.24905
Journal Paper I24-Microfocus Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access
PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions Dna Repair, 50 Feb 2017 DOI: 10.1016/j.dnarep.2016.12.003
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural insights into human angiogenin variants implicated in Parkinson’s disease and Amyotrophic Lateral Sclerosis Scientific Reports, 7 Feb 2017 DOI: 10.1038/srep41996
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease Acs Chemical Biology, Feb 2017 DOI: 10.1021/acschembio.6b01048
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin Bioorganic & Medicinal Chemistry Letters, Feb 2017 DOI: 10.1016/j.bmcl.2017.02.028
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin Matrix Biology, Feb 2017 DOI: 10.1016/j.matbio.2017.02.002
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
The complete structure of an activated open sodium channel Nature Communications, 8 Feb 2017 DOI: 10.1038/ncomms14205
A natural, single-residue substitution yields a less active peptaibiotic: the structure of bergofungin A at atomic resolution Acta Crystallographica Section F Structural Biology Communications, 73 Feb 2017 DOI: 10.1107/S2053230X17001236
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding Proceedings Of The National Academy Of Sciences, Feb 2017 DOI: 10.1073/pnas.1612927114
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognizes a peptide derived from human telomerase reverse transcriptase Journal Of Biological Chemistry, 292 Jan 2017 DOI: 10.1074/jbc.M116.741603
Journal Paper B23-Circular Dichroism I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for nutrient acquisition by dominant members of the human gut microbiota Nature, 541 Jan 2017 DOI: 10.1038/nature20828
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
MraY–antibiotic complex reveals details of tunicamycin mode of action Nature Chemical Biology, Jan 2017 DOI: 10.1038/nchembio.2270
Macrocyclized extended peptides: Inhibiting the substrate-recognition domain of tankyrase Journal Of The American Chemical Society, Jan 2017 DOI: 10.1021/jacs.6b10234
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
- Jingshan Ren, Yuguang Zhao, Elizabeth E. Fry, David I. Stuart, "Target identification and mode of action of four chemically divergent drugs against Ebola virus infection", Journal Of Medicinal Chemistry (2017), DOI: 10.1021/acs.jmedchem.7b01249
- Ana S. Luis, Jonathon Briggs, Xiaoyang Zhang, Benjamin Farnell, Didier Ndeh, Aurore Labourel, Arnaud Basle, Alan Cartmell, Nicolas Terrapon, Katherine Stott, Elisabeth C. Lowe, Richard Mclean, Kaitlyn Shearer, Julia Schückel, Immacolata Venditto, Marie-Christine Ralet, Bernard Henrissat, Eric C. Martens, Steven C. Mosimann, D. Wade Abbott, Harry J. Gilbert, "Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides", Nature Microbiology, 344 (2017), DOI: 10.1038/s41564-017-0079-1
- M. J. Bryant, J. M. Skelton, L. E. Hatcher, C. Stubbs, E. Madrid, A. R. Pallipurath, L. H. Thomas, Ch. H. Woodall, J. Christensen, S. Fuertes, T. P. Robinson, C. M. Beavers, S. J. Teat, M. Warren, F. Pradaux-Caggiano, A. Walsh, F. Marken, D. R. Carbery, S. C. Parker, N. B. Mckeown, R. Malpass-Evans, M. Carta, P. R. Raithby, "A rapidly-reversible absorptive and emissive vapochromic Pt(II) pincer-based chemical sensor", Nature Communications, 8 (2017), DOI: 10.1038/s41467-017-01941-2
- Neha Patel, Florian Stengel, Ruedi Aebersold, Matthew G. Gold, "Molecular basis of AKAP79 regulation by calmodulin", Nature Communications, 8 (2017), DOI: 10.1038/s41467-017-01715-w
- Benjamin Cressiot, Sandra J. Greive, Wei Si, Tomas Pascoa, Mehrnaz Mojtabavi, Maria Chechik, Huw T. Jenkins, Xueguang Lu, Ke Zhang, Aleksei Aksimentiev, Alfred A. Antson, Meni Wanunu, "Porphyrin-assisted docking of a thermophage portal protein into lipid bilayers: nanopore engineering and characterization", Acs Nano (2017), DOI: 10.1021/acsnano.7b06980
- Claudine Bisson, Nathan B. P. Adams, Ben Stevenson, Amanda A. Brindley, Despo Polyviou, Thomas S. Bibby, Patrick J. Baker, C. Neil Hunter, Andrew Hitchcock, "The molecular basis of phosphite and hypophosphite recognition by ABC-transporters", Nature Communications, 8 (2017), DOI: 10.1038/s41467-017-01226-8
- Montse Tersa, Lluís Raich, David Albesa-Jove, Beatriz Trastoy, Jacques Prandi, Martine Gilleron, Carme Rovira, Marcelo Guerin, "The molecular mechanism of substrate recognition and catalysis of the membrane acyltransferase PatA from mycobacteria", Acs Chemical Biology (2017), DOI: 10.1021/acschembio.7b00578
- C. G. Burton, Danny Axford, Andrew Michael John Edwards, Richard J. Gildea, Robert H. Morris, Michael I. Newton, Allen M. Orville, Mark Prince, Paul D. Topham, Peter D. Docker, "An acoustic on-chip goniometer for room temperature macromolecular crystallography", Lab On A Chip (2017), DOI: 10.1039/C7LC00812K
- David K. Cole, Anna Fuller, Garry Dolton, Efthalia Zervoudi, Mateusz Legut, Kim Miles, Lori Blanchfield, Florian Madura, Christopher J. Holland, Anna M. Bulek, John S. Bridgeman, John J. Miles, Andrea J. A. Schauenburg, Konrad Beck, Brian D. Evavold, Pierre Rizkallah, Andrew K. Sewell, "Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope", Frontiers In Immunology, 8 (2017), DOI: 10.3389/fimmu.2017.01503
- Allister Crow, Nicholas Greene, Elise Kaplan, Vassilis Koronakis, "Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily", Proceedings Of The National Academy Of Sciences, 23 (2017), DOI: 10.1073/pnas.1712153114
- Arnaud Basle, Lorraine Hewitt, Alan Koh, Heather K. Lamb, Paul Thompson, J. Grant Burgess, Michael J. Hall, Alastair R. Hawkins, Heath Murray, Richard J. Lewis, "Crystal structure of NucB, a biofilm-degrading endonuclease", Nucleic Acids Research (2017), DOI: 10.1093/nar/gkx1170
- Inokentijs Josts, Christopher James Stubenrauch, Grishma Vadlamani, Khedidja Mosbahi, Daniel Walker, Trevor Lithgow, Rhys Grinter, "The structure of a conserved domain of TamB reveals a hydrophobic β taco fold", Structure (2017), DOI: 10.1016/j.str.2017.10.002
- Joanne L. Parker, Simon Newstead, "Structural basis of nucleotide sugar transport across the Golgi membrane", Nature, 343 (2017), DOI: 10.1038/nature24464
- Robert Kolodziejczyk, Kornelia M. Mikula, Tommi Kotila, Vincent L. G. Postis, T. Sakari Jokiranta, Adrian Goldman, Taru Meri, "Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi", Plos One, 12 (2017), DOI: 10.1371/journal.pone.0188127
- Joanne L. Parker, Chenghan Li, Allete Brinth, Zhi Wang, Lutz Vogeley, Nicolae Solcan, Gregory Ledderboge-Vucinic, Jessica M. J. Swanson, Martin Caffrey, Gregory A. Voth, Simon Newstead, "Proton movement and coupling in the POT family of peptide transporters", Proceedings Of The National Academy Of Sciences, 63 (2017), DOI: 10.1073/pnas.1710727114
- Roger Springett, Martin S. King, Paul G. Crichton, Edmund R. S. Kunji, "Modelling the free energy profile of the mitochondrial ADP/ATP carrier", Biochimica Et Biophysica Acta (bba) - Bioenergetics, 1858, 906 - 914 (2017), DOI: 10.1016/j.bbabio.2017.05.006
- Steffen Preissler, Lukas Rohland, Yahui Yan, Ruming Chen, Randy J. Read, David Ron, "AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation", Elife, 6 (2017), DOI: 10.7554/eLife.29428
- Maria-Armineh Tossounian, Inge Van Molle, Khadija Wahni, Silke Jacques, Kris Gevaert, Frank Van Breusegem, Didier Vertommen, David Young, Leonardo Astolfi Rosado, Joris Messens, "Disulfide bond formation protects Arabidopsis thaliana glutathione transferase tau 23 from oxidative damage", Biochimica Et Biophysica Acta (bba) - General Subjects (2017), DOI: 10.1016/j.bbagen.2017.10.007
- Javier Abellon-Ruiz, Shreyas S. Kaptan, Arnaud Basle, Beatrice Claudi, Dirk Bumann, Ulrich Kleinekathöfer, Bert Van Den Berg, "Structural basis for maintenance of bacterial outer membrane lipid asymmetry", Nature Microbiology, 70 (2017), DOI: 10.1038/s41564-017-0046-x
- Juan Carro, Marta Martinez-Julvez, Milagros Medina, Angel T. Martínez, Patricia Ferreira, "Protein dynamics promote hydride tunnelling in substrate oxidation by aryl-alcohol oxidase", Physical Chemistry Chemical Physics, 19, 28666 - 28675 (2017), DOI: 10.1039/C7CP05904C
- [Conference Paper] T. B. Garcia-Nathan, A. Kachatkou, C. Jiang, D. Omar, J. Marchal, H. Changani, N. Tartoni, R. G. Van Silfhout, "Compact and portable X-ray imager system using Medipix3RX", Journal Of Instrumentation, 12, C10011 - C10011 (2017), DOI: 10.1088/1748-0221/12/10/C10011
- Andrew S. Dore, Andrea Bortolato, Kaspar Hollenstein, Robert K. Y. Cheng, Randy J. Read, Fiona H. Marshall, "Decoding corticotropin-releasing factor receptor type 1 crystal structures", Current Molecular Pharmacology, 10 (2017), DOI: 10.2174/1874467210666170110114727
- Nicholas J. Weise, Syed T. Ahmed, Fabio Parmeggiani, James L. Galman, Mark S. Dunstan, Simon J. Charnock, David Leys, Nicholas J. Turner, "Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes", Scientific Reports, 7 (2017), DOI: 10.1038/s41598-017-13990-0
- Alexander Schubert, Christina Gladkova, Els Pardon, Jane L. Wagstaff, Stefan M. V. Freund, Jan Steyaert, Sarah L. Maslen, David Komander, "Structure of PINK1 in complex with its substrate ubiquitin", Nature (2017), DOI: 10.1038/nature24645
- Soledad Banos-Mateos, Anne-Marie M. Van Roon, Ulla F. Lang, Sarah L. Maslen, J. Mark Skehel, Meindert Lamers, "High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center", Nature Communications, 8 (2017), DOI: 10.1038/s41467-017-00886-w
- Duncan Laverty, Philip Thomas, Martin Field, Ole J. Andersen, Matthew G. Gold, Philip C. Biggin, Marc Gielen, Trevor G. Smart, "Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites", Nature Structural & Molecular Biology, 22 (2017), DOI: 10.1038/nsmb.3477
- Malte Gersch, Christina Gladkova, Alexander F. Schubert, Martin A. Michel, Sarah Maslen, David Komander, "Mechanism and regulation of the Lys6-selective deubiquitinase USP30", Nature Structural & Molecular Biology (2017), DOI: 10.1038/nsmb.3475
- Marcelo E. Guerin, David Albesa-Jove, Maria-Angela Sainz-Polo, Alberto Marina, "Structural snapshots of α-1,3-galactosyltransferase with native substrates: insight into the catalytic mechanism of retaining glycosyltransferases", Angewandte Chemie International Edition (2017), DOI: 10.1002/anie.201707922
- Emil Hamnevik, Thilak Reddy Enugala, Dirk Maurer, Siphosethu Ntuku, Ana Oliveira, Doreen Dobritzsch, Mikael Widersten, "Relaxation of nonproductive binding and increased rate of coenzyme release in an alcohol dehydrogenase increases turnover with a non-preferred alcohol enantiomer", The Febs Journal (2017), DOI: 10.1111/febs.14279
- Omri Snir, Xi Chen, Moriah Gidoni, M. Fleur Du Pré, Yuguang Zhao, Øyvind Steinsbø, Knut E. A. Lundin, Gur Yaari, Ludvig M. Sollid, "Stereotyped antibody responses target posttranslationally modified gluten in celiac disease", Jci Insight, 2 (2017), DOI: 10.1172/jci.insight.93961
- Joanna Panecka-Hofman, Ina Pöhner, Francesca Spyrakis, Talia Zeppelin, Flavio Di Pisa, Lucia Dello Iacono, Alessio Bonucci, Antonio Quotadamo, Alberto Venturelli, Stefano Mangani, Maria Paola Costi, Rebecca C. Wade, "Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors", Biochimica Et Biophysica Acta (bba) - General Subjects (2017), DOI: 10.1016/j.bbagen.2017.09.012
- Anastasia Mylona, Stephen Carr, Pierre Aller, Isabel Moraes, Richard Treisman, Gwyndaf Evans, James Foadi, "A novel approach to data collection for difficult structures: data management for large numbers of crystals with the BLEND software", Crystals, 7 (2017), DOI: 10.3390/cryst7080242
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- [Science Highlight] Diamond Light Source, "Beating the sugar rush" (2017)
- Sherine E. Thomas, Vitor Mendes, So Yeon Kim, Sony Malhotra, Bernardo Ochoa-Montano, Michal Blaszczyk, Tom L. Blundell, "Structural biology and the design of new therapeutics: from HIV and cancer to mycobacterial infections", Journal Of Molecular Biology (2017), DOI: 10.1016/j.jmb.2017.06.014
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