Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
93 items found for 2014 [total: 1243]
Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides European Journal Of Immunology, Dec 2014 DOI: 10.1002/eji.201445114
Crystallographic studies evidencing the high energy tolerance to disrupting the interface disulfide bond of thioredoxin 1 from white leg shrimp Litopenaeus vannamei Molecules, 19 (12) Dec 2014 DOI: 10.3390/molecules191221113
Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions Structure, 22 (12) Dec 2014 DOI: 10.1016/j.str.2014.10.007
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Discovery of selective small-molecule activators of a bacterial glycoside hydrolase Angewandte Chemie International Edition, 53 (49) Dec 2014 DOI: 10.1002/anie.201407081
Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase Nature, 516 (7529) Dec 2014 DOI: 10.1038/nature14003
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
5-Formylcytosine alters the structure of the DNA double helix Nature Structural & Molecular Biology, 22 (1) Dec 2014 DOI: 10.1038/nsmb.2936
Journal Paper I24-Microfocus Macromolecular Crystallography
Characterisation of the morphological and surface properties of organic micro-crystalline particles Dec 2014
Thesis I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Exploiting whole-PDB analysis in novel bioinformatics applications Dec 2014
Thesis I24-Microfocus Macromolecular Crystallography open access
Recognition of the small regulatory RNA RydC by the bacterial Hfq protein Elife, 3 Dec 2014 DOI: 10.7554/eLife.05375
Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers Nature Communications, 5 Nov 2014 DOI: 10.1038/ncomms6491
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Closing the cohesin ring: Structure and function of its Smc3-kleisin interface Science, 346 (6212) Nov 2014 DOI: 10.1126/science.1256917
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights The Journal Of General Physiology, 144 (6) Nov 2014 DOI: 10.1085/jgp.201411219
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Exploring nicotinamide cofactor promiscuity in NAD(P)H-dependent flavin containing monooxygenases (FMOs) using natural variation within the phosphate binding loop. Structure and activity of FMOs from Cellvibrio sp. BR and Pseudomonas stutzeri NF13 Journal Of Molecular Catalysis B: Enzymatic, 109 Nov 2014 DOI: 10.1016/j.molcatb.2014.08.019
Molecular recognition of RhlB and RNase D in the Caulobacter crescentus RNA degradosome Nucleic Acids Research, 42 (21) Nov 2014 DOI: 10.1093/nar/gku1134
Untangling the mysteries of curli fibres Nov 2014
Science Highlight I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development Neuron, 84 (2) Oct 2014 DOI: 10.1016/j.neuron.2014.10.008
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A novel small-molecule MRCK inhibitor blocks cancer cell invasion Cell Communication And Signaling, 12 Oct 2014 DOI: 10.1186/s12964-014-0054-x
Time-resolved crystallography using the Hadamard transform Nature Methods, Oct 2014 DOI: 10.1038/nmeth.3139
Journal Paper I24-Microfocus Macromolecular Crystallography
Hepatitis A virus and the origins of picornaviruses Nature, 517 (7532) Oct 2014 DOI: 10.1038/nature13806
Cloning, expression, purification, crystallization and preliminary X-ray diffraction of a lysine-specific permease from Pseudomonas aeruginosa Acta Crystallographica Section F Structural Biology Communications, 70 Oct 2014 DOI: 10.1107/S2053230X14017865
Journal Paper I24-Microfocus Macromolecular Crystallography
New methods for indexing multi-lattice diffraction data Acta Crystallographica Section D Biological Crystallography, 70 Oct 2014 DOI: 10.1107/S1399004714017039
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly Plos Pathogens, 10 (10) Oct 2014 DOI: 10.1371/journal.ppat.1004459
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters Nature Structural & Molecular Biology, 21 (11) Oct 2014 DOI: 10.1038/nsmb.2894
Journal Paper I24-Microfocus Macromolecular Crystallography
High thermodynamic stability of parametrically designed helical bundles Science, 346 (6208) Oct 2014 DOI: 10.1126/science.1257481
Journal Paper I24-Microfocus Macromolecular Crystallography
How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties Journal Of Medicinal Chemistry, 57 (20) Oct 2014 DOI: 10.1021/jm5010754
Journal Paper I24-Microfocus Macromolecular Crystallography
I24 endstation upgrade - overview and engineering design Oct 2014
Conference Paper I24-Microfocus Macromolecular Crystallography open access
Structure and interactions of the Bacillus subtilis sporulation inhibitor of DNA replication, SirA, with domain I of DnaA Molecular Microbiology, 93 (5) Sept 2014 DOI: 10.1111/mmi.12713
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1 Nature Communications, 5 Sept 2014 DOI: 10.1038/ncomms5874
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Space-group and origin ambiguity in macromolecular structures with pseudo-symmetry and its treatment with the program Zanuda Acta Crystallographica Section D Biological Crystallography, 70 Sept 2014 DOI: 10.1107/S1399004714014795
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG Nature, Sept 2014 DOI: 10.1038/nature13768
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystal structures and functional studies clarify substrate selectivity and catalytic residues for the unique orphan enzyme N-acetyl-D-mannosamine dehydrogenase Biochemical Journal, 462 Sept 2014 DOI: 10.1042/BJ20140266
Journal Paper I24-Microfocus Macromolecular Crystallography
The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain Journal Of Biological Chemistry, 289 (36) Sept 2014 DOI: 10.1074/jbc.M114.566257
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structural insight into host recognition by aggregative adherence fimbriae of enteroaggregative Escherichia coli Plos Pathogens, 10 (9) Sept 2014 DOI: 10.1371/journal.ppat.1004404
Structural analysis of the complex formed between the ansamycin antibiotic rifabutin and the BCL6 BTB-POZ domain Sept 2014
Thesis I24-Microfocus Macromolecular Crystallography
Pushing the limits of sulfur SAD phasing: de novo structure solution of the N-terminal domain of the ectodomain of HCV E1 Acta Crystallographica Section D Biological Crystallography, 70 Aug 2014 DOI: 10.1107/S139900471401339X
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and mechanistic insight into the Listeria monocytogenes two-enzyme lipoteichoic acid synthesis system Journal Of Biological Chemistry, Aug 2014 DOI: 10.1074/jbc.M114.590570
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters Embo Reports, 15 (8) Aug 2014 DOI: 10.15252/embr.201338403
Crystal structure of Schistosoma mansoni HGPRT isoform 1 Aug 2014
Poster I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump Febs Letters, 588 (17) Aug 2014 DOI: 10.1016/j.febslet.2014.06.055
A conformational landscape for alginate secretion across the outer Purification, crystallization and preliminary X-ray diffraction analysis of GatD, a glutamine amidotransferase-like protein from Staphylococcus aureus peptidoglycanaureus peptidoglycan Acta Crystallographica Section D Biological Crystallography, 70 Aug 2014 DOI: 10.1107/S1399004714001850
Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N -acetylgalactosaminyltransferase 2 Angewandte Chemie International Edition, 53 (31) Jul 2014 DOI: 10.1002/anie.201402781
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains Journal Of The American Chemical Society, 136 (26) Jul 2014 DOI: 10.1021/ja412434f
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain Nature, 511 (7511) Jul 2014 DOI: 10.1038/nature13396
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural basis of chitin oligosaccharide deacetylation Angewandte Chemie International Edition, 53 (27) Jul 2014 DOI: 10.1002/anie.201400220
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The crystal structure of ferritin from Chlorobium tepidum reveals a new conformation of the 4-fold channel for this protein family Biochimie, Jul 2014 DOI: 10.1016/j.biochi.2014.07.019
Journal Paper I24-Microfocus Macromolecular Crystallography
Renaturing membrane proteins in the lipid cubic phase, a nanoporous membrane mimetic Scientific Reports, 4 Jul 2014 DOI: 10.1038/srep05806
Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination Cellular And Molecular Life Sciences, Jul 2014 DOI: 10.1007/s00018-014-1655-7
Journal Paper I24-Microfocus Macromolecular Crystallography
Lysosome sorting of beta-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor Nature Communications, 5 Jul 2014 DOI: 10.1038/ncomms5321
Crystallization and preliminary analysis of the NqrA and NqrC subunits of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae Acta Crystallographica Section F Structural Biology Communications, 70 (7) Jul 2014 DOI: 10.1107/S2053230X14009881
X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism Nature Communications, 5 June 2014 DOI: 10.1038/ncomms5169
Journal Paper I24-Microfocus Macromolecular Crystallography
The peptide-binding cavity is essential for Als3-mediated adhesion of Candida albicans to human cells Journal Of Biological Chemistry, 289 (26) June 2014 DOI: 10.1074/jbc.M114.547877
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site Chemical Science, 5 (9) June 2014 DOI: 10.1039/C4SC01443J
Journal Paper I24-Microfocus Macromolecular Crystallography
The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors Protein Science, 23 (6) June 2014 DOI: 10.1002/pro.2456
Structural basis for outer membrane lipopolysaccharide insertion Nature, 511 (7507) June 2014 DOI: 10.1038/nature13464
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Characterization of two homologous 2′-O-methyltransferases showing different specificities for their tRNA substrates Rna, 20 (8) June 2014 DOI: 10.1261/rna.044503.114
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Exploiting fast detectors to enter a new dimension in room-temperature crystallography Acta Crystallographica Section D Biological Crystallography, 70 May 2014 DOI: 10.1107/S1399004714005379
Structure and inhibition of mouse leukotriene C4 synthase Plos One, 9 (5) May 2014 DOI: 10.1371/journal.pone.0096763
The X-ray crystal structure of Shewanella oneidensis OmcA reveals new insight at the microbe-mineral interface Febs Letters, 588 (10) May 2014 DOI: 10.1016/j.febslet.2014.04.013
Journal Paper I24-Microfocus Macromolecular Crystallography
Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae Elife, 3 May 2014 DOI: 10.7554/eLife.02674
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Biochemical and structural characterisation of a haloalkane dehalogenase from a marine Rhodobacteraceae Febs Letters, 588 (9) May 2014 DOI: 10.1016/j.febslet.2014.02.056
The structure of a class 3 nonsymbiotic plant haemoglobin from Acta Crystallographica Section D Biological Crystallography, 70 May 2014 DOI: 10.1107/S1399004714004878
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure of the AcrAB-TolC multidrug efflux pump Nature, 509 (7501) May 2014 DOI: 10.1038/nature13205
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
In cellulo structure determination of a novel cypovirus polyhedrin Acta Crystallographica Section D Biological Crystallography, 70 May 2014 DOI: 10.1107/S1399004714004714
Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications Protein Engineering Design And Selection, 27 (5) Apr 2014 DOI: 10.1093/protein/gzu007
Structural insight into how Streptomyces coelicolor maltosyl transferase GlgE binds alpha-maltose 1-phosphate and forms a maltosyl-enzyme intermediate Biochemistry, 53 (15) Apr 2014 DOI: 10.1021/bi500183c
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Binding mode and structure–activity relationships around direct inhibitors of the Nrf2–Keap1 complex Chemmedchem, 9 (4) Apr 2014 DOI: 10.1002/cmdc.201300525
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystallizing membrane proteins in the lipidic mesophase. experience with human prostaglandin E2 Synthase 1 and an evolving strategy Crystal Growth & Design, 14 (4) Mar 2014 DOI: 10.1021/cg500157x
Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans Molecular Cell, 53 (5) Mar 2014 DOI: 10.1016/j.molcel.2014.01.015
Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP) Journal Of Medicinal Chemistry, 57 (6) Mar 2014 DOI: 10.1021/jm500066b
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase Nature Communications, 5 Mar 2014 DOI: 10.1038/ncomms5395
A new crystal structure of the bifunctional antibiotic simocyclinone D8 bound to DNA gyrase gives fresh insight into the mechanism of inhibition Journal Of Molecular Biology, Mar 2014 DOI: 10.1016/j.jmb.2014.02.017
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain Plos One, 9 (3) Mar 2014 DOI: 10.1371/journal.pone.0090889
Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis Open Biology, 4 (3) Mar 2014 DOI: 10.1098/rsob.130232
Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3 Biochemistry, 53 (14) Mar 2014 DOI: 10.1021/bi5002344
Journal Paper I24-Microfocus Macromolecular Crystallography
Pyruvate kinases have an intrinsic and conserved decarboxylase activity Biochemical Journal, 458 (2) Mar 2014 DOI: 10.1042/BJ20130790
Structural and mechanistic insights into an extracytoplasmic copper trafficking pathway in Streptomyces lividans Biochemical Journal, Feb 2014 DOI: 10.1042/BJ20140017
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules Nature Structural & Molecular Biology, 21 (3) Feb 2014 DOI: 10.1038/nsmb.2769
Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor Plos Pathogens, 10 (2) Feb 2014 DOI: 10.1371/journal.ppat.1003898
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Global low-frequency motions in protein allostery: CAP as a model system Biophysical Reviews , 7 (163) Feb 2014 DOI: 10.1007/s12551-015-0163-9
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Visualizing autophosphorylation in histidine kinases Nature Communications, 5 Feb 2014 DOI: 10.1038/ncomms4258
Journal Paper I24-Microfocus Macromolecular Crystallography
A bacterial homolog of a eukaryotic inositol phosphate signaling enzyme mediates cross-kingdom dialog in the mammalian gut Cell Reports, 6 (4) Feb 2014 DOI: 10.1016/j.celrep.2014.01.021
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein Structure, 22 (2) Feb 2014 DOI: 10.1016/j.str.2013.06.028
Structure, function and substrate tolerance of TxtC Feb 2014
Thesis I24-Microfocus Macromolecular Crystallography
Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation Nucleic Acids Research, Jan 2014 DOI: 10.1093/nar/gku085
Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection Structure, Jan 2014 DOI: 10.1016/j.str.2013.12.004
Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism Proceedings Of The National Academy Of Sciences, 111 (4) Jan 2014 DOI: 10.1073/pnas.1320692111
Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation Proceedings Of The National Academy Of Sciences, 111 (4) Jan 2014 DOI: 10.1073/pnas.1317262111
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structures of adenosine kinase from Trypanosoma brucei brucei Acta Crystallographica Section F Structural Biology Communications, 70 Jan 2014 DOI: 10.1107/S2053230X13033621
Structural basis for binding of fluorinated glucose and galactose to Trametes multicolor pyranose 2-oxidase variants with improved galactose conversion Plos One, 9 (1) Jan 2014 DOI: 10.1371/journal.pone.0086736
Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A Biological Chemistry, 395 Jan 2014 DOI: 10.1515/hsz-2014-0106
Journal Paper I24-Microfocus Macromolecular Crystallography
Crystal structure of a Schistosoma mansoni septin reveals the phenomenon of strand slippage in septins dependent on the nature of the bound nucleotide Journal Of Biological Chemistry, 289 (11) Jan 2014 DOI: 10.1074/jbc.M113.525352
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains Journal Of Biological Chemistry, 289 (1) Jan 2014 DOI: 10.1074/jbc.M113.501833
- Florian Madura, Pierre Rizkallah, Christopher J. Holland, Anna Fuller, Anna Bulek, Andrew J Godkin, Andrea J. Schauenburg, David K. Cole, Andrew K. Sewell, "Structural basis for ineffective T-cell responses to MHC anchor residue-improved “heteroclitic” peptides", European Journal Of Immunology (2014), DOI: 10.1002/eji.201445114
- Adam Campos-Acevedo, Enrique Rudiño-Piñera, "Crystallographic studies evidencing the high energy tolerance to disrupting the interface disulfide bond of thioredoxin 1 from white leg shrimp Litopenaeus vannamei", Molecules, 19 (12), 21113 - 21126 (2014), DOI: 10.3390/molecules191221113
- Tom D. Bunney, Ambrose R. Cole, Malgorzata Broncel, Diego Esposito, Edward W. Tate, Matilda Katan, "Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions", Structure, 22 (12), 1831 - 1843 (2014), DOI: 10.1016/j.str.2014.10.007
- John Darby, Jens Landstrom, Christian Roth, Yuan He, Gideon J. Davies, Roderick E. Hubbard, "Discovery of selective small-molecule activators of a bacterial glycoside hydrolase", Angewandte Chemie International Edition, 53 (49), 13419 - 13423 (2014), DOI: 10.1002/anie.201407081
- Julia Steuber, Georg Vohl, Marco S. Casutt, Thomas Vorburger, Kay Diederichs, Guenter Fritz, "Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase", Nature, 516 (7529), 62 - 67 (2014), DOI: 10.1038/nature14003
- Eun-Ang Raiber, Pierre Murat, Dima Chirgadze, Dario Beraldi, Ben Luisi, Shankar Balasubramanian, "5-Formylcytosine alters the structure of the DNA double helix", Nature Structural & Molecular Biology, 22 (1), 44 - 49 (2014), DOI: 10.1038/nsmb.2936
- [Thesis] Siti Nurul’ain Yusop, "Characterisation of the morphological and surface properties of organic micro-crystalline particles" (2014)
- [Thesis] Varun Ramraj, "Exploiting whole-PDB analysis in novel bioinformatics applications" (2014)
- Daniela Dimastrogiovanni, Kathrin S. Fröhlich, Katarzyna J. Bandyra, Heather A. Bruce, Susann Hohensee, Jörg Vogel, Ben F. Luisi, "Recognition of the small regulatory RNA RydC by the bacterial Hfq protein", Elife, 3 (2014), DOI: 10.7554/eLife.05375
- Chancievan Thangaratnarajah, Jonathan Ruprecht, Edmund Kunji, "Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers", Nature Communications, 5 (2014), DOI: 10.1038/ncomms6491
- T. G. Gligoris, J. Scheinost, F. Burmann, N. Petela, K.-L. Chan, P. Uluocak, F. Beckouet, S. Gruber, K. Nasmyth, J. Lowe, "Closing the cohesin ring: Structure and function of its Smc3-kleisin interface", Science, 346 (6212), 963 - 967 (2014), DOI: 10.1126/science.1256917
- C. Lee, S. Yashiro, D. L. Dotson, P. Uzdavinys, S. Iwata, M. S. P. Sansom, C. Von Ballmoos, O. Beckstein, D. Drew, A. D. Cameron, "Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights", The Journal Of General Physiology, 144 (6), 529 - 544 (2014), DOI: 10.1085/jgp.201411219
- Chantel N. Jensen, Sohail T. Ali, Michael J. Allen, Gideon Grogan, "Exploring nicotinamide cofactor promiscuity in NAD(P)H-dependent flavin containing monooxygenases (FMOs) using natural variation within the phosphate binding loop. Structure and activity of FMOs from Cellvibrio sp. BR and Pseudomonas stutzeri NF13", Journal Of Molecular Catalysis B: Enzymatic, 109, 191 - 198 (2014), DOI: 10.1016/j.molcatb.2014.08.019
- Jarrod E. Voss, Ben F. Luisi, Steven W. Hardwick, "Molecular recognition of RhlB and RNase D in the Caulobacter crescentus RNA degradosome", Nucleic Acids Research, 42 (21), 13294 - 13305 (2014), DOI: 10.1093/nar/gku1134
- [Science Highlight] Diamond Light Source, "Untangling the mysteries of curli fibres" (2014)
- Elena Seiradake, Daniel Del toro, Daniel Nagel, Florian Cop, Ricarda Härtl, Tobias Ruff, Gönül Seyit-Bremer, Karl Harlos, Ellen clare Border, Amparo Acker-Palmer, E. Yvonne Jones, Rüdiger Klein, "FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development", Neuron, 84 (2), 370 - 385 (2014), DOI: 10.1016/j.neuron.2014.10.008
- Mathieu Unbekandt, Daniel R. Croft, Diane Crighton, Mokdad Mezna, Duncan Mcarthur, Patricia Mcconnell, Alexander W. Schüttelkopf, Simone Belshaw, Andrew Pannifer, Mairi Sime, Justin Bower, Martin Drysdale, Michael F. Olson, "A novel small-molecule MRCK inhibitor blocks cancer cell invasion", Cell Communication And Signaling, 12, 3583-3590 (2014), DOI: 10.1186/s12964-014-0054-x
- Briony Yorke, Robin Owen, Godfrey Beddard, Arwen Pearson, "Time-resolved crystallography using the Hadamard transform", Nature Methods (2014), DOI: 10.1038/nmeth.3139
- Xiangxi Wang, Jingshan Ren, Qiang Gao, Zhongyu Hu, Yao Sun, Xuemei Li, David J. Rowlands, Weidong Yin, Junzhi Wang, David I. Stuart, Zihe Rao, Elizabeth E. Fry, "Hepatitis A virus and the origins of picornaviruses", Nature, 517 (7532), 85 - 88 (2014), DOI: 10.1038/nature13806
- Emmanuel Nji, Dianfan Li, Declan Doyle, Martin Caffrey, "Cloning, expression, purification, crystallization and preliminary X-ray diffraction of a lysine-specific permease from Pseudomonas aeruginosa", Acta Crystallographica Section F Structural Biology Communications, 70, 1362 - 1367 (2014), DOI: 10.1107/S2053230X14017865
- Richard Gildea, David G. Waterman, James Parkhurst, Danny Axford, Geoff Sutton, David I. Stuart, Nicholas K. Sauter, Gwyndaf Evans, Graeme Winter, "New methods for indexing multi-lattice diffraction data", Acta Crystallographica Section D Biological Crystallography, 70, 2652 - 2666 (2014), DOI: 10.1107/S1399004714017039
- Amanda J. Price, David Jacques, William A. Mcewan, Adam J. Fletcher, Sebastian Essig, Jason W. Chin, Upul D. Halambage, Christopher Aiken, Leo C. James, "Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly", Plos Pathogens, 10 (10) (2014), DOI: 10.1371/journal.ppat.1004459
- Lina Malinauskaite, Matthias Quick, Linda Reinhard, Joseph A Lyons, Hideaki Yano, Jonathan A Javitch, Poul Nissen, "A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters", Nature Structural & Molecular Biology, 21 (11), 1006 - 1012 (2014), DOI: 10.1038/nsmb.2894
- P.-S. Huang, G. Oberdorfer, C. Xu, X. Y. Pei, B. L. Nannenga, J. M. Rogers, F. Dimaio, T. Gonen, B. Luisi, D. Baker, "High thermodynamic stability of parametrically designed helical bundles", Science, 346 (6208), 481 - 485 (2014), DOI: 10.1126/science.1257481
- Benny D. Belviso, Rocco Caliandro, Modesto De Candia, Giorgia Zaetta, Gianfranco Lopopolo, Francesca Incampo, Mario Colucci, Cosimo D. Altomare, "How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties", Journal Of Medicinal Chemistry, 57 (20), 8563 - 8575 (2014), DOI: 10.1021/jm5010754
- [Conference Paper] Vinay Grama, Danny Axford, Robin Owen, "I24 endstation upgrade - overview and engineering design" (2014)
- Katie H. Jameson, Nadia Rostami, Mark J. Fogg, Johan P. Turkenburg, Anne Grahl, Heath Murray, Anthony J. Wilkinson, "Structure and interactions of the Bacillus subtilis sporulation inhibitor of DNA replication, SirA, with domain I of DnaA", Molecular Microbiology, 93 (5), 975 - 991 (2014), DOI: 10.1111/mmi.12713
- Kamel El Omari, Oleg Iourin, Jan Kadlec, Geoff Sutton, Karl Harlos, Jonathan M. Grimes, David I. Stuart, "Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1", Nature Communications, 5 (2014), DOI: 10.1038/ncomms5874
- Andrey A. Lebedev, Misha N. Isupov, "Space-group and origin ambiguity in macromolecular structures with pseudo-symmetry and its treatment with the program Zanuda", Acta Crystallographica Section D Biological Crystallography, 70, 2430 - 2443 (2014), DOI: 10.1107/S1399004714014795
- Parveen Goyal, Petya V. Krasteva, Nani Van Gerven, Francesca Gubellini, Imke Van Den Broeck, Anastassia Troupiotis-Tsaïlaki, Wim Jonckheere, Gérard Péhau-Arnaudet, Jerome S. Pinkner, Matthew R. Chapman, Scott J. Hultgren, Stefan Howorka, Remi Fronzes, Han Remaut, "Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG", Nature (2014), DOI: 10.1038/nature13768
- Agustan Sola-Carvajal, Fernando Gilâ-Ortiz, Francisco Garcã-Carmona, Vicente Rubio, Alvaro Sanchez-Ferrer, "Crystal structures and functional studies clarify substrate selectivity and catalytic residues for the unique orphan enzyme N-acetyl-D-mannosamine dehydrogenase", Biochemical Journal, 462, 499 - 511 (2014), DOI: 10.1042/BJ20140266
- Alvin Wei Han Lo, Kristof Moonens, Maia De Kerpel, Lea Brys, Els Pardon, Han Remaut, Henry. De Greve, "The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain", Journal Of Biological Chemistry, 289 (36), 25374 - 25381 (2014), DOI: 10.1074/jbc.M114.566257
- Andrea A. Berry, Yi Yang, Natalia Pakharukova, James Garnett, Wei-Chao Lee, Ernesto Cota, Jan Marchant, Saumendra Roy, Minna Tuittila, Bing Liu, Keith G. Inman, Fernando Ruiz-Perez, Inacio Mandomando, James P. Nataro, Anton V. Zavialov, Steve Matthews, "Structural insight into host recognition by aggregative adherence fimbriae of enteroaggregative Escherichia coli", Plos Pathogens, 10 (9) (2014), DOI: 10.1371/journal.ppat.1004404
- [Thesis] Sian E. Evans, "Structural analysis of the complex formed between the ansamycin antibiotic rifabutin and the BCL6 BTB-POZ domain" (2014)
- Kamel El Omari, Oleg Iourin, Jan Kadlec, Richard Fearn, David R. Hall, Karl Harlos, Jonathan M. Grimes, David I. Stuart, "Pushing the limits of sulfur SAD phasing: de novo structure solution of the N-terminal domain of the ectodomain of HCV E1", Acta Crystallographica Section D Biological Crystallography, 70, 2197 - 2203 (2014), DOI: 10.1107/S139900471401339X
- Paul S. Miller, A. Radu Aricescu, "Crystal structure of a human GABAA receptor", Nature, 512 (7514), 270 - 275 (2014), DOI: 10.1038/nature13293
- Ivan Campeotto, Matthew G. Percy, James T. Macdonald, Andreas Forster, Paul S. Freemont, Angelika Gründling, "Structural and mechanistic insight into the Listeria monocytogenes two-enzyme lipoteichoic acid synthesis system", Journal Of Biological Chemistry (2014), DOI: 10.1074/jbc.M114.590570
- Joseph A. Lyons, Joanne Parker, Nicolae Solcan, Alette Brinth, Dianfan Li, Syed T. A. Shah, Martin Caffrey, Simon Newstead, "Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters", Embo Reports, 15 (8), 886 - 893 (2014), DOI: 10.15252/embr.201338403
- [Poster] Larissa Romanello, Juliana Torini De Souza, Louise Bird, J. Nettleship, Ray Owens, Jose Brandao-Neto, Humberto Pereira, "Crystal structure of Schistosoma mansoni HGPRT isoform 1" (2014)
- Philip Hinchliffe, Nicholas P. Greene, Neil G. Paterson, Allister Crow, Colin Hughes, Vassilis Koronakis, "Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump", Febs Letters, 588 (17), 3147 - 3153 (2014), DOI: 10.1016/j.febslet.2014.06.055
- Jingquan Tan, Sarah L. Rouse, Dianfan Li, Valerie Pye, Lutz Vogeley, Alette Brinth, Toufic El Arnaout, John C. Whitney, P. Lynne Howell, Mark S. P. Sansom, Martin Caffrey, "A conformational landscape for alginate secretion across the outer Purification, crystallization and preliminary X-ray diffraction analysis of GatD, a glutamine amidotransferase-like protein from Staphylococcus aureus peptidoglycanaureus peptidoglycan", Acta Crystallographica Section D Biological Crystallography, 70, 2054 - 2068 (2014), DOI: 10.1107/S1399004714001850
- Erandi Lira, Javier Iglesias-Fernandez, Wesley F. Zandberg, Ismael Compañón, Yun Kong, Francisco Corzana, B. Mario Pinto, Henrik Clausen, Jesús M. Peregrina, David J. Vocadlo, Carme Rovira, Ramon Hurtado-Guerrero, "Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N -acetylgalactosaminyltransferase 2", Angewandte Chemie International Edition, 53 (31), 8206 - 8210 (2014), DOI: 10.1002/anie.201402781
- Duncan A. Hay, Oleg Fedorov, Sarah Martin, Dean C. Singleton, Cynthia Tallant Blanco, Christopher Wells, Sarah Picaud, Martin Philpott, Octovia P. Monteiro, Catherine M. Rogers, Stuart J. Conway, Timothy P. C. Rooney, Anthony Tumber, Clarence Yapp, Panagis Filippakopoulos, Mark E. Bunnage, Susanne Müller, S Knapp, Christopher J. Schofield, Paul E. Brennan, "Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains", Journal Of The American Chemical Society, 136 (26), 9308 - 9319 (2014), DOI: 10.1021/ja412434f
- Andrew Dore, Krzysztof Okrasa, Jayesh C. Patel, Maria Serrano-Vega, Kirstie Bennett, Robert M. Cooke, James C. Errey, Ali Jazayeri, Samir Khan, Ben Tehan, Malcolm Weir, Giselle R. Wiggin, Fiona H. Marshall, "Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain", Nature, 511 (7511), 557 - 562 (2014), DOI: 10.1038/nature13396
- David Albesa-Jove, Marcelo Guerin, Eduardo Andres, Xevi Biarnés, Bruno M. Moerschbacher, Antoni Planas, "Structural basis of chitin oligosaccharide deacetylation", Angewandte Chemie International Edition, 53 (27), 6882 6887 (2014), DOI: 10.1002/anie.201400220
- Mauricio Arenas-Salinas, Philip Townsend, Christian Brito, Valeria Marquez, Vanessa Marabolli, Fernando Gonzalez-Nilo, Cata Matias, Richard K. Watt, Juan D. López-Castro, José Domínguez-Vera, Ehmke Pohl, Alejandro Yévenes, "The crystal structure of ferritin from Chlorobium tepidum reveals a new conformation of the 4-fold channel for this protein family", Biochimie (2014), DOI: 10.1016/j.biochi.2014.07.019
- Dianfan Li, Martin Caffrey, "Renaturing membrane proteins in the lipid cubic phase, a nanoporous membrane mimetic", Scientific Reports, 4 (2014), DOI: 10.1038/srep05806
- Coilín Boland, Dianfan Li, Syed Tasadaque Ali Shah, Stefan Haberstock, Volker Dötsch, Frank Bernhard, Martin Caffrey, "Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination", Cellular And Molecular Life Sciences (2014), DOI: 10.1007/s00018-014-1655-7
- Yuguang Zhao, Jingshan Ren, Sergi Padilla-Parra, Elizabeth E. Fry, David I. Stuart, "Lysosome sorting of beta-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor", Nature Communications, 5 (2014), DOI: 10.1038/ncomms5321
- Georg Vohl, Ruslan Nedielkov, Björn Claussen, Marco S. Casutt, Thomas Vorburger, Kay Diederichs, Heiko M. Möller, Julia Steuber, Guenter Fritz, "Crystallization and preliminary analysis of the NqrA and NqrC subunits of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae", Acta Crystallographica Section F Structural Biology Communications, 70 (7), 987 - 992 (2014), DOI: 10.1107/S2053230X14009881
- Przemyslaw Nogly, Ivan Gushchin, Alina Remeeva, Ana M. Esteves, Nuno Borges, Pikyee Ma, Andrii Ishchenko, Sergei Grudinin, Ekaterina Round, Isabel Moraes, Valentin Borshchevskiy, Helena Santos, Valentin Gordeliy, Margarida Archer, "X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism", Nature Communications, 5 (2014), DOI: 10.1038/ncomms5169
- Jing Lin, Soon.-Hwan Oh, Rhian Jones, James Garnett, Paula Salgado, Sophia Rusnakova, Steve J. Matthews, Lois L. Hoyer, Ernesto Cota, "The peptide-binding cavity is essential for Als3-mediated adhesion of Candida albicans to human cells", Journal Of Biological Chemistry, 289 (26), 18401 - 18412 (2014), DOI: 10.1074/jbc.M114.547877
- Anna Maria Perna, Felix Reisen, Thomas P. Schmidt, Tim Geppert, Max Pillong, Martin Weisel, Benjamin Hoy, Philip C. Simister, Stephan M. Feller, Silja Wessler, Gisbert Schneider, "Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site", Chemical Science, 5 (9) (2014), DOI: 10.1039/C4SC01443J
- Sebastian Lambert, David R. Langley, James Garnett, Richard Angell, Katy Hedgethorne, Nicholas A. Meanwell, Steve J. Matthews, "The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors", Protein Science, 23 (6), 723 - 734 (2014), DOI: 10.1002/pro.2456
- Haohao Dong, Quanju Xiang, Yinghong Gu, Zhongshan Wang, Neilg. Paterson, Phillip J. Stansfeld, Chuan He, Yizheng Zhang, Wenjian Wang, Changjiang Dong, "Structural basis for outer membrane lipopolysaccharide insertion", Nature, 511 (7507), 52 - 56 (2014), DOI: 10.1038/nature13464
- Jonathan Somme, Bart Van Laer, Martine Roovers, Jan Steyaert, Wim Versées, Louis Droogmans, "Characterization of two homologous 2′-O-methyltransferases showing different specificities for their tRNA substrates", Rna, 20 (8), 1257 - 1271 (2014), DOI: 10.1261/rna.044503.114
- Robin L. Owen, Neil Paterson, Danny Axford, Jun Aishima, Clemens Schulze-Briese, Jingshan Ren, Elizabeth E. Fry, David I. Stuart, Gwyndaf Evans, "Exploiting fast detectors to enter a new dimension in room-temperature crystallography", Acta Crystallographica Section D Biological Crystallography, 70, 1248 - 1256 (2014), DOI: 10.1107/S1399004714005379
- Damian Niegowski, Thea Kleinschmidt, Shabbir Ahmad, Abdul Aziz Qureshi, Michaela Mårback, Agnes Rinaldo-Matthis, Jesper Z. Haeggström, Ivano Eberini, "Structure and inhibition of mouse leukotriene C4 synthase", Plos One, 9 (5) (2014), DOI: 10.1371/journal.pone.0096763
- Marcus J. Edwards, Nanakow A. Baiden, Alexander Johs, Stephen J. Tomanicek, Liyuan Liang, Liang Shi, Jim K. Fredrickson, John M. Zachara, Andrew J. Gates, Julea N. Butt, David J. Richardson, Thomas A. Clarke, "The X-ray crystal structure of Shewanella oneidensis OmcA reveals new insight at the microbe-mineral interface", Febs Letters, 588 (10), 1886 - 1890 (2014), DOI: 10.1016/j.febslet.2014.04.013
- Cedric Leyrat, Max Renner, Karl Harlos, Juha T. Huiskonen, Jonathan M. Grimes, "Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae", Elife, 3 (2014), DOI: 10.7554/eLife.02674
- Halina R. Novak, Christopher Sayer, Misha Isupov, Dorothee Gotz, Andrew Mearns Spragg, Jennifer Littlechild, "Biochemical and structural characterisation of a haloalkane dehalogenase from a marine Rhodobacteraceae", Febs Letters, 588 (9), 1616 - 1622 (2014), DOI: 10.1016/j.febslet.2014.02.056
- Brandon Reeder, Mike Hough, "The structure of a class 3 nonsymbiotic plant haemoglobin from", Acta Crystallographica Section D Biological Crystallography, 70, 1411 - 1418 (2014), DOI: 10.1107/S1399004714004878
- Dijun Du, Zhao Wang, Nathan R. James, Jarrod E. Voss, Ewa Klimont, Thelma Ohene-Agyei, Henrietta Venter, Wah Chiu, Ben F. Luisi, "Structure of the AcrAB-TolC multidrug efflux pump", Nature, 509 (7501), 512 - 515 (2014), DOI: 10.1038/nature13205
- Danny Axford, Xiaoyun Ji, Dave Stuart, Geoff Sutton, "In cellulo structure determination of a novel cypovirus polyhedrin", Acta Crystallographica Section D Biological Crystallography, 70, 1435 - 1441 (2014), DOI: 10.1107/S1399004714004714
- C. Tiede, A. A. S. Tang, S. E. Deacon, U. Mandal, J. E. Nettleship, R. L. Owen, S. E. George, D. J. Harrison, R. J. Owens, D. C. Tomlinson, M. J. Mcpherson, "Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications", Protein Engineering Design And Selection, 27 (5), 145 - 155 (2014), DOI: 10.1093/protein/gzu007
- Karl Syson, Clare Stevenson, Abdul M. Rashid, Gerhard Saalbach, Minhong Tang, Anne Tuukkanen, Dmitri I. Svergun, Stephen G. Withers, David Lawson, Stephen Bornemann, "Structural insight into how Streptomyces coelicolor maltosyl transferase GlgE binds alpha-maltose 1-phosphate and forms a maltosyl-enzyme intermediate", Biochemistry, 53 (15), 2494 - 2504 (2014), DOI: 10.1021/bi500183c
- Eric Jnoff, Claudia Albrecht, John J. Barker, Oliver Barker, Edward Beaumont, Steven Bromidge, Frederick Brookfield, Mark Brooks, Christian Bubert, Tom Ceska, Vincent Corden, Graham Dawson, Stephanie Duclos, Tara Fryatt, Christophe Genicot, Emilie Jigorel, Jason Kwong, Rosemary Maghames, Innocent Mushi, Richard Pike, "Binding mode and structure–activity relationships around direct inhibitors of the Nrf2–Keap1 complex", Chemmedchem, 9 (4), 699 - 705 (2014), DOI: 10.1002/cmdc.201300525
- Dianfan Li, Nicole Howe, Abhiram Dukkipati, Syed T. A. Shah, Benjamin D. Bax, Colin Edge, Angela Bridges, Phil Hardwicke, Onkar M. P. Singh, Ged Giblin, Alexander Pautsch, Roland Pfau, Gisela Schnapp, Meitian Wang, Vincent Olieric, Martin Caffrey, "Crystallizing membrane proteins in the lipidic mesophase. experience with human prostaglandin E2 Synthase 1 and an evolving strategy", Crystal Growth & Design, 14 (4) (2014), DOI: 10.1021/cg500157x
- Ivan Plaza-Menacho, Karin Barnouin, Kerry Goodman, Rubén J. Martínez-Torres, Annabel Borg, Judith Murray-Rust, Stephane Mouilleron, Phillip Knowles, Neil Q. Mcdonald, "Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans", Molecular Cell, 53 (5), 738 - 751 (2014), DOI: 10.1016/j.molcel.2014.01.015
- Mark D. Rackham, James A. Brannigan, Kaveri Rangachari, Stephan Meister, Anthony Wilkinson, Anthony A. Holder, Robin J. Leatherbarrow, Edward W. Tate, "Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP)", Journal Of Medicinal Chemistry, 57 (6), 2773 - 2788 (2014), DOI: 10.1021/jm500066b
- Nicole G. H. Leferink, Svetlana V. Antonyuk, Joseline A. Houwman, Nigel S. Scrutton, Robert R. Eady, Samar Hasnain, "Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase", Nature Communications, 5 (2014), DOI: 10.1038/ncomms5395
- Stephen Hearnshaw, Marcus Edwards, Clare Stevenson, David Lawson, Anthony Maxwell, "A new crystal structure of the bifunctional antibiotic simocyclinone D8 bound to DNA gyrase gives fresh insight into the mechanism of inhibition", Journal Of Molecular Biology (2014), DOI: 10.1016/j.jmb.2014.02.017
- Sian Evans, Benjamin T. Goult, Louise Fairall, Andrew G. Jamieson, Paul Ko Ferrigno, Robert Ford, John W. R. Schwabe, Simon D. Wagner, "The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain", Plos One, 9 (3) (2014), DOI: 10.1371/journal.pone.0090889
- Nana-Maria Gruning, Dijun Du, M. A. Keller, Ben Luisi, M. Ralser, "Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis", Open Biology, 4 (3), 130232 - 130232 (2014), DOI: 10.1098/rsob.130232
- Katherine L. Portman, Jed Long, Stephen Carr, Loïc Briand, Donald J. Winzor, Mark S. Searle, Dave Scott, "Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3", Biochemistry, 53 (14), 2371 - 2379 (2014), DOI: 10.1021/bi5002344
- Wenhe Zhong, Hugh P. Morgan, Matthew W. Nowicki, Iain W. Mcnae, Meng Yuan, Juraj Bella, Paul A. M. Michels, Linda A. Fothergill-Gilmore, Malcolm D. Walkinshaw, "Pyruvate kinases have an intrinsic and conserved decarboxylase activity", Biochemical Journal, 458 (2), 301 - 311 (2014), DOI: 10.1042/BJ20130790
- Michael A. Hough, Katie L. I. M. Blundell, Jonathan Worrall, Erik Vijgenboom, "Structural and mechanistic insights into an extracytoplasmic copper trafficking pathway in Streptomyces lividans", Biochemical Journal (2014), DOI: 10.1042/BJ20140017
- Luigi De Colibus, Xiangxi Wang, John A. B. Spyrou, James Kelly, Jingshan Ren, Jonathan Grimes, Gerhard Puerstinger, Nicola Stonehouse, Thomas Walter, Zhongyu Hu, Junzhi Wang, Xuemei Li, Wei Peng, David J. Rowlands, Elizabeth E. Fry, Zihe Rao, David I. Stuart, "More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules", Nature Structural & Molecular Biology, 21 (3), 282 - 288 (2014), DOI: 10.1038/nsmb.2769
- Laura C. Mccaughey, Rhys Grinter, Inokentijs Josts, Aleksander Roszak, Kai I. Waløen, Richard J. Cogdell, Joel Milner, Tom Evans, Sharon Kelly, Nicholas P. Tucker, Olwyn Byron, Brian Smith, Daniel Walker, "Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor", Plos Pathogens, 10 (2) (2014), DOI: 10.1371/journal.ppat.1003898
- Ehmke Pohl, Philip D. Townsend, Thomas L. Rodgers, Mark R. Wilson, Tom C. B. Mcleish, Martin J. Cann, "Global low-frequency motions in protein allostery: CAP as a model system", Biophysical Reviews , 7 (163) (2014), DOI: 10.1007/s12551-015-0163-9
- Patricia Casino, Laura Miguel-Romero, Alberto Marina, "Visualizing autophosphorylation in histidine kinases", Nature Communications, 5 (2014), DOI: 10.1038/ncomms4258
- Régis Stentz, Samantha Osborne, Nikki Horn, Arthur w. H. Li, Isabelle Hautefort, Roy Bongaerts, Marine Rouyer, Paul Bailey, Stephen B. Shears, Andrew M. Hemmings, Charles A. Brearley, Simon R. Carding, "A bacterial homolog of a eukaryotic inositol phosphate signaling enzyme mediates cross-kingdom dialog in the mammalian gut", Cell Reports, 6 (4), 646 - 656 (2014), DOI: 10.1016/j.celrep.2014.01.021
- Ann-Kathrin a Becker, Halina Mikolajek, Mats Paulsson, Raimund Wagener, Joern Werner, "A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein", Structure, 22 (2), 199 - 208 (2014), DOI: 10.1016/j.str.2013.06.028
- [Thesis] Lona Alkhalaf, "Structure, function and substrate tolerance of TxtC" (2014)
- Wei Shen Aik, John Scotti, Hwanho Choi, Lingzhi Gong, Marina Demetriades, Christopher J. Schofield, Michael Mcdonough, "Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation", Nucleic Acids Research (2014), DOI: 10.1093/nar/gku085
- Charlotte Hodson, Andy Purkiss, Jennifer A. Miles, Helen Walden, "Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection", Structure (2014), DOI: 10.1016/j.str.2013.12.004
- Jonathan J. Ruprecht, Alex M. Hellawell, Marilyn Harding, Paul G. Crichton, Airlie J. Mccoy, Edmund R. S. Kunji, "Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism", Proceedings Of The National Academy Of Sciences, 111 (4), E426 - E434 (2014), DOI: 10.1073/pnas.1320692111
- Sian J. Tanner, Antonio Ariza, Charles-Adrien Richard, Hannah F. Kyle, Rachel L. Dods, Maire-Lise Blondot, Weining Wu, Jose Trincao, Chi H. Trinh, Julian A. Hiscox, Miles W. Carroll, Nigel J. Silman, Jean-Francois Eleouet, Thomas A. Edwards, John N. Barr, "Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation", Proceedings Of The National Academy Of Sciences, 111 (4), 1580 - 1585 (2014), DOI: 10.1073/pnas.1317262111
- Jennifer Timm, Dolores González-Pacanowska, Keith S. Wilson, "Structures of adenosine kinase from Trypanosoma brucei brucei", Acta Crystallographica Section F Structural Biology Communications, 70, 34 - 39 (2014), DOI: 10.1107/S2053230X13033621
- Tien Chye Tan, Oliver Spadiut, Rosaria Gandini, Dietmar Haltrich, Christina Divne, "Structural basis for binding of fluorinated glucose and galactose to Trametes multicolor pyranose 2-oxidase variants with improved galactose conversion", Plos One, 9 (1) (2014), DOI: 10.1371/journal.pone.0086736
- Christian Low, Esben Quistgaard, Michael Kovermann, Madhanagopal Anandapadamanaban, Jochen Balbach, Pär Nordlund, "Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A", Biological Chemistry, 395 (2014), DOI: 10.1515/hsz-2014-0106
- A. E. Zeraik, H. M. Pereira, Y. V. Santos, J. Brandao-Neto, M. Spoerner, M. S. Santos, L. A. Colnago, R. C. Garratt, A. P. U. Araujo, R. Demarco, "Crystal structure of a Schistosoma mansoni septin reveals the phenomenon of strand slippage in septins dependent on the nature of the bound nucleotide", Journal Of Biological Chemistry, 289 (11), 7799 - 7811 (2014), DOI: 10.1074/jbc.M113.525352
- L. Zubcevic, V. N. Bavro, J. R. C Muniz, M. R. Schmidt, S. Wang, R. De Zorzi, C. Venien-Bryan, M. S. P. Sansom, C. G. Nichols, S. J. Tucker, "Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains", Journal Of Biological Chemistry, 289 (1), 143 - 151 (2014), DOI: 10.1074/jbc.M113.501833
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
Diamond Light Source Ltd
Diamond House
Harwell Science & Innovation Campus
Didcot
Oxfordshire
OX11 0DE
Copyright © Diamond Light Source. Diamond Light Source® and the Diamond logo are registered trademarks of Diamond Light Source Ltd
Registered in England and Wales at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom. Company number: 4375679. VAT number: 287 461 957. Economic Operators Registration and Identification (EORI) number: GB287461957003.