Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
107 items found for 2019 [total: 1243]
Mycobacterial OtsA structures unveil substrate preference mechanism and allosteric regulation by 2-oxoglutarate and 2-phosphoglycerate Mbio, 10 Dec 2019 DOI: 10.1128/mBio.02272-19
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Photoreversible interconversion of a phytochrome photosensory module in the crystalline state Proceedings Of The National Academy Of Sciences, 37 Dec 2019 DOI: 10.1073/pnas.1912041116
Comparison of orexin 1 and orexin 2 ligand binding modes using X-ray crystallography and computational analysis Journal Of Medicinal Chemistry, Dec 2019 DOI: 10.1021/acs.jmedchem.9b01787
Cellular IP6 levels limit HIV production while viruses that cannot efficiently package IP6 are attenuated for infection and replication Cell Reports, 29 Dec 2019 DOI: 10.1016/j.celrep.2019.11.050
Molecular basis for GTP recognition by light‐activated guanylate cyclase RhGC The Febs Journal, Dec 2019 DOI: 10.1111/febs.15167
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography VMXi-Versatile Macromolecular Crystallography in situ open access
A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus Life Science Alliance, 3 Dec 2019 DOI: 10.26508/lsa.201900578
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection Proceedings Of The National Academy Of Sciences, 64 Dec 2019 DOI: 10.1073/pnas.1911776116
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite The Faseb Journal, Nov 2019 DOI: 10.1096/fj.201901741R
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Desolvation of the substrate binding protein TauA dictates ligand specificity for the alkanesulfonate ABC importer TauABC Biochemical Journal, Nov 2019 DOI: 10.1042/BCJ20190779
Journal Paper I03-Macromolecular Crystallography I23-Long wavelength MX I24-Microfocus Macromolecular Crystallography open access
Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors Scientific Reports, 9 Nov 2019 DOI: 10.1038/s41598-019-52795-1
Crystal structures of the Bacillus subtilis prophage lytic cassette proteins XepA and YomS Acta Crystallographica Section D Structural Biology, 75 Nov 2019 DOI: 10.1107/S2059798319013330
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation Scientific Reports, 9 Nov 2019 DOI: 10.1038/s41598-019-50702-2
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
PMP–diketopiperazine adducts form at the active site of a PLP dependent enzyme involved in formycin biosynthesis Chemical Communications, 55 Nov 2019 DOI: 10.1039/C9CC06975E
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
DNA SOS: Understanding DNA signaling pathways Nov 2019
Science Highlight I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors Bioorganic & Medicinal Chemistry Letters, Oct 2019 DOI: 10.1016/j.bmcl.2019.126751
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism Nature Chemical Biology, 15 Oct 2019 DOI: 10.1038/s41589-019-0370-y
Journal Paper I04-Macromolecular Crystallography I23-Long wavelength MX I24-Microfocus Macromolecular Crystallography
Structural insight into eukaryotic sterol transport through Niemann-Pick Type C proteins Cell, Oct 2019 DOI: 10.1016/j.cell.2019.08.038
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond
Lessons from LIMK1 enzymology and their impact on inhibitor design Biochemical Journal, Oct 2019 DOI: 10.1042/BCJ20190517
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Enhancing PLP-binding capacity of class-III ω-transaminase by single residue substitution Frontiers In Bioengineering And Biotechnology, 7 Oct 2019 DOI: 10.3389/fbioe.2019.00282
Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut Nature Microbiology, 14 Oct 2019 DOI: 10.1038/s41564-019-0590-7
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography VMXi-Versatile Macromolecular Crystallography in situ
Acceptance and kinetic resolution of α-methyl-substituted aldehydes by norcoclaurine synthases Acs Catalysis, Sept 2019 DOI: 10.1021/acscatal.9b02699
Journal Paper I24-Microfocus Macromolecular Crystallography
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K Nature Communications, 10 Sept 2019 DOI: 10.1038/s41467-019-11753-1
OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo Nature Communications, 10 Sept 2019 DOI: 10.1038/s41467-019-11756-y
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A chemical probe for tudor domain protein spindlin1 to investigate chromatin function Journal Of Medicinal Chemistry, Sept 2019 DOI: 10.1021/acs.jmedchem.9b00562
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A family of dual-activity glycosyltransferase-phosphorylases mediates mannogen turnover and virulence in Leishmania parasites Cell Host & Microbe, 26 Sept 2019 DOI: 10.1016/j.chom.2019.08.009
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structures of influenza A virus RNA polymerase offer insight into viral genome replication Nature, 573 Sept 2019 DOI: 10.1038/s41586-019-1530-7
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography Krios I-Titan Krios I at Diamond
Structural basis for inhibition of human primase by arabinofuranosyl nucleoside analogues fludarabine and vidarabine Acs Chemical Biology, Sept 2019 DOI: 10.1021/acschembio.9b00367
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Homomeric GluA2(R) AMPA receptors can conduct when desensitized Nature Communications, 10 Sept 2019 DOI: 10.1038/s41467-019-12280-9
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome Proceedings Of The National Academy Of Sciences, 5 Sept 2019 DOI: 10.1073/pnas.1912705116
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Reducing sample consumption for serial crystallography using acoustic drop ejection Journal Of Synchrotron Radiation, 26 Sept 2019 DOI: 10.1107/S1600577519009329
Structural basis of light-induced redox regulation in the Calvin–Benson cycle in cyanobacteria Proceedings Of The National Academy Of Sciences, 75 Sept 2019 DOI: 10.1073/pnas.1906722116
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography Krios I-Titan Krios I at Diamond Krios III-Titan Krios III at Diamond open access
A new target for malaria research Sept 2019
Science Highlight I24-Microfocus Macromolecular Crystallography
New structure for human flu virus protein Sept 2019
Science Highlight B21-High Throughput SAXS I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography Krios I-Titan Krios I at Diamond
The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus Molecular Immunology, 112 Aug 2019 DOI: 10.1016/j.molimm.2019.04.026
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Towards the competent conformation for catalysis in the ferredoxin-NADP+ reductase from the Brucella ovis pathogen Biochimica Et Biophysica Acta (bba) - Bioenergetics, Aug 2019 DOI: 10.1016/j.bbabio.2019.148058
Journal Paper I24-Microfocus Macromolecular Crystallography
Molecular basis of Class A β-lactamase inhibition by relebactam Antimicrobial Agents And Chemotherapy, Aug 2019 DOI: 10.1128/AAC.00564-19
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition Proceedings Of The National Academy Of Sciences, 175 Aug 2019 DOI: 10.1073/pnas.1909393116
Distortion of mannoimidazole supports a B 2,5 boat transition state for the family GH125 α-1,6-mannosidase from Clostridium perfringens Organic & Biomolecular Chemistry, 45 Aug 2019 DOI: 10.1039/C9OB01161G
The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model Nature Communications, 10 Aug 2019 DOI: 10.1038/s41467-019-11508-y
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning Nature Communications, 10 Aug 2019 DOI: 10.1038/s41467-019-11683-y
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Non-contact universal sample presentation for room temperature macromolecular crystallography using acoustic levitation Scientific Reports, 9 Aug 2019 DOI: 10.1038/s41598-019-48612-4
Crystal structure and substrate-induced activation of ADAMTS13 Nature Communications, 10 Aug 2019 DOI: 10.1038/s41467-019-11474-5
Bicyclic boronate VNRX-5133 inhibits metallo- and serine-β-lactamases Journal Of Medicinal Chemistry, Aug 2019 DOI: 10.1021/acs.jmedchem.9b00911
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Developing chemical tools for the inhibition of activin A signalling Aug 2019 DOI: 10.17863/CAM.54235
Thesis I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase Bioorganic & Medicinal Chemistry, 27 Aug 2019 DOI: 10.1016/j.bmc.2019.06.015
Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins Iucrj, 6 Jul 2019 DOI: 10.1107/S2052252519003956
Direct measurement of X-ray-induced heating of microcrystals Journal Of Synchrotron Radiation, 26 Jul 2019 DOI: 10.1107/S1600577519003849
Development of inhibitors against Mycobacterium abscessus tRNA (m 1 G37) methyltransferase (TrmD) using fragment-based approaches Journal Of Medicinal Chemistry, Jul 2019 DOI: 10.1021/acs.jmedchem.9b00809
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Radiation-damage investigation of a DNA 16-mer Journal Of Synchrotron Radiation, 26 Jul 2019 DOI: 10.1107/S160057751900763X
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural basis for recruitment of DAPK1 to the KLHL20 E3 ligase Structure, Jul 2019 DOI: 10.1016/j.str.2019.06.005
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax Nature Microbiology, 8 Jul 2019 DOI: 10.1038/s41564-019-0499-1
C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly Febs Open Bio, 72 Jul 2019 DOI: 10.1002/2211-5463.12700
Crystal structures of the recombinant β-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics Acta Crystallographica Section D Structural Biology, 75 June 2019 DOI: 10.1107/S2059798319006910
Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation Plos Biology, June 2019 DOI: 10.1371/journal.pbio.3000315
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens Plos Pathogens, June 2019 DOI: 10.1371/journal.ppat.1007865
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase Nature Communications, 10 June 2019 DOI: 10.1038/s41467-019-10190-4
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Domain-interface dynamics of CFTR revealed by stabilizing nanobodies Nature Communications, 10 June 2019 DOI: 10.1038/s41467-019-10714-y
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability Nature Cell Biology, June 2019 DOI: 10.1038/s41556-019-0337-y
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping Philosophical Transactions Of The Royal Society A: Mathematical, Physical And Engineering Sciences, 377 June 2019 DOI: 10.1098/rsta.2018.0422
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Mapping the structural path for allosteric inhibition of a short-form ATP phosphoribosyltransferase by histidine Biochemistry, June 2019 DOI: 10.1021/acs.biochem.9b00282
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design Nature Chemical Biology, June 2019 DOI: 10.1038/s41589-019-0294-6
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
A noncanonical chromophore reveals structural rearrangements of the light-oxygen-voltage domain upon photoactivation Biochemistry, May 2019 DOI: 10.1021/acs.biochem.9b00255
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Navigating the structural landscape of de novo α-helical bundles Journal Of The American Chemical Society, May 2019 DOI: 10.1021/jacs.8b13354
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis Communications Biology, 2 May 2019 DOI: 10.1038/s42003-019-0427-1
The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry Nature Communications, 10 May 2019 DOI: 10.1038/s41467-019-10220-1
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Distant non-obvious mutations influence the activity of a hyperthermophilic pyrococcus furiosus phosphoglucose isomerase Biomolecules, 9 May 2019 DOI: 10.3390/biom9060212
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Unexpected roles of a tether harboring a tyrosine gatekeeper residue in modular nitrite reductase catalysis Acs Catalysis, May 2019 DOI: 10.1021/acscatal.9b01266
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4 European Journal Of Medicinal Chemistry, May 2019 DOI: 10.1016/j.ejmech.2019.05.057
Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib Blood Advances, 3 May 2019 DOI: 10.1182/bloodadvances.2018027011
Journal Paper I24-Microfocus Macromolecular Crystallography
Molecular basis for high-affinity agonist binding in GPCRs Science, May 2019 DOI: 10.1126/science.aau5595
Journal Paper I24-Microfocus Macromolecular Crystallography
The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases Nature Structural & Molecular Biology, 2 May 2019 DOI: 10.1038/s41594-019-0227-9
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The structure of lipopolysaccharide transport protein B (LptB) from Burkholderia pseudomallei Acta Crystallographica Section F Structural Biology Communications, 75 Apr 2019 DOI: 10.1107/S2053230X19001778
Journal Paper I24-Microfocus Macromolecular Crystallography
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis Proceedings Of The National Academy Of Sciences, 116 Apr 2019 DOI: 10.1073/pnas.1814685116
Revisiting SEPT7 and the slippage of β-strands in the septin family Journal Of Structural Biology, Apr 2019 DOI: 10.1016/j.jsb.2019.04.015
Journal Paper I24-Microfocus Macromolecular Crystallography
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen Medchemcomm, Apr 2019 DOI: 10.1039/C9MD00096H
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
(p)ppGpp regulates a bacterial nucleosidase by an allosteric two-domain switch Molecular Cell, Apr 2019 DOI: 10.1016/j.molcel.2019.03.035
Journal Paper I24-Microfocus Macromolecular Crystallography
Comparison of the structures and mechanisms of the pistol and hammerhead ribozymes Journal Of The American Chemical Society, Apr 2019 DOI: 10.1021/jacs.9b02141
Synthesis and structure–Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH European Journal Of Medicinal Chemistry, Apr 2019 DOI: 10.1016/j.ejmech.2019.04.027
FragLites - minimal, halogenated fragments displaying pharmacophore doublets. An efficient approach to druggability assessment and hit generation Journal Of Medicinal Chemistry, Mar 2019 DOI: 10.1021/acs.jmedchem.9b00304
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs Autophagy, 21 Mar 2019 DOI: 10.1080/15548627.2019.1581009
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
High-resolution structure of cas13b and biochemical characterization of RNA targeting and cleavage Cell Reports, 26 Mar 2019 DOI: 10.1016/j.celrep.2019.02.094
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Directed assembly of homo-pentameric cholera toxin B-subunit proteins into higher-order structures using coiled-coil appendages Journal Of The American Chemical Society, Mar 2019 DOI: 10.1021/jacs.8b11480
Conservation of the structural and functional architecture of encapsulated ferritins in bacteria and archaea Biochemical Journal, 476 Mar 2019 DOI: 10.1042/BCJ20180922
Structural comparison of enterococcus faecalis and human thymidylate synthase complexes with the substrate dUMP and its analogue FdUMP provides hints about enzyme conformational variabilities Molecules, 24 Mar 2019 DOI: 10.3390/molecules24071257
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone-based compounds The Febs Journal, 255 Mar 2019 DOI: 10.1111/febs.14790
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
How best to use photons Acta Crystallographica Section D Structural Biology, 75 Mar 2019 DOI: 10.1107/S2059798319003528
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A parsimonious mechanism of sugar dehydration by human GDP-mannose-4,6-dehydratase Acs Catalysis, Mar 2019 DOI: 10.1021/acscatal.9b00064
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Peptide super-agonist enhances T-cell responses to melanoma Frontiers In Immunology, 10 Mar 2019 DOI: 10.3389/fimmu.2019.00319
Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor Science, 363 Mar 2019 DOI: 10.1126/science.aaw2859
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural and functional analysis of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II Journal Of Biological Chemistry, Mar 2019 DOI: 10.1074/jbc.RA118.006626
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Protein crystal presentation for synchrotron methods: acoustic techniques Mar 2019
Thesis I24-Microfocus Macromolecular Crystallography
Deciphering the molecular mechanism underpinning phage arbitrium communication systems Molecular Cell, Feb 2019 DOI: 10.1016/j.molcel.2019.01.025
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure-based in silico screening identifies a potent ebolavirus inhibitor from a traditional Chinese medicine library Journal Of Medicinal Chemistry, Feb 2019 DOI: 10.1021/acs.jmedchem.8b01328
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins Nature Communications, 10 Feb 2019 DOI: 10.1038/s41467-019-08728-7
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access
Mechanism of regulation and neutralization of the AtaR–AtaT toxin–antitoxin system Nature Chemical Biology, 29 Feb 2019 DOI: 10.1038/s41589-018-0216-z
Journal Paper I24-Microfocus Macromolecular Crystallography
Design, 3D printing and validation of a novel low-cost high-capacity sitting-drop bridge for protein crystallization Journal Of Applied Crystallography, 52 Feb 2019 DOI: 10.1107/S1600576718017545
Journal Paper I24-Microfocus Macromolecular Crystallography
Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs Scientific Reports, 9 Feb 2019 DOI: 10.1038/s41598-018-37330-y
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni Hypoxanthine-guanine phosphoribosyltransferases Molecular And Biochemical Parasitology, Feb 2019 DOI: 10.1016/j.molbiopara.2019.02.005
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structural insights into tiny bacterial harpoons Feb 2019
Science Highlight I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes Nature Communications, 10 Jan 2019 DOI: 10.1038/s41467-018-08056-2
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and functional characterization of a frataxin from a thermophilic organism The Febs Journal, Jan 2019 DOI: 10.1111/febs.14750
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
The structure of the catalytic domain of the ATP synthase from Mycobacterium smegmatis is a target for developing antitubercular drugs Proceedings Of The National Academy Of Sciences, 60 Jan 2019 DOI: 10.1073/pnas.1817615116
Crystal structure of the plant symporter STP10 illuminates sugar uptake mechanism in monosaccharide transporter superfamily Nature Communications, 10 Jan 2019 DOI: 10.1038/s41467-018-08176-9
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of the human cannabinoid receptor CB2 Cell, Jan 2019 DOI: 10.1016/j.cell.2018.12.011
Journal Paper I24-Microfocus Macromolecular Crystallography
Architecture of microcin B17 synthetase: an octameric protein complex converting a ribosomally synthesized peptide into a DNA gyrase poison Molecular Cell, Jan 2019 DOI: 10.1016/j.molcel.2018.11.032
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters Proceedings Of The National Academy Of Sciences, 116 Jan 2019 DOI: 10.1073/pnas.1813715116
An esterase‐like lyase catalyzes acetate elimination in spirotetronate/spirotetramate biosynthesis Angewandte Chemie International Edition, Jan 2019 DOI: 10.1002/anie.201812105
- Vitor Mendes, Marta Acebron Garcia De Eulate, Nupur Verma, Michael Blaszczyk, Márcio V. B. Dias, Tom L. Blundell, "Mycobacterial OtsA structures unveil substrate preference mechanism and allosteric regulation by 2-oxoglutarate and 2-phosphoglycerate", Mbio, 10 (2019), DOI: 10.1128/mBio.02272-19
- E. Sethe Burgie, Jonathan A. Clinger, Mitchell D. Miller, Aaron S. Brewster, Pierre Aller, Agata Butryn, Franklin D. Fuller, Sheraz Gul, Iris D. Young, Cindy C. Pham, In-Sik Kim, Asmit Bhowmick, Lee J. O’riordan, Kyle D. Sutherlin, Joshua V. Heinemann, Alexander Batyuk, Roberto Alonso-Mori, Mark S. Hunter, Jason E. Koglin, Junko Yano, Vittal K. Yachandra, Nicholas K. Sauter, Aina E. Cohen, Jan Kern, Allen M. Orville, George N. Phillips, Richard D. Vierstra, "Photoreversible interconversion of a phytochrome photosensory module in the crystalline state", Proceedings Of The National Academy Of Sciences, 37 (2019), DOI: 10.1073/pnas.1912041116
- Mathieu Rappas, Ammar Ali, Kirstie A. Bennett, Jason D. Brown, Sarah J. Bucknell, Miles Congreve, Robert M. Cooke, Gabriella Cseke, Chris De Graaf, Andrew S. Dore, James C. Errey, Ali Jazayeri, Fiona H. Marshall, Jonathan S. Mason, Richard Mould, Jayesh C. Patel, Benjamin G. Tehan, Malcolm Weir, John A. Christopher, "Comparison of orexin 1 and orexin 2 ligand binding modes using X-ray crystallography and computational analysis", Journal Of Medicinal Chemistry (2019), DOI: 10.1021/acs.jmedchem.9b01787
- Donna L. Mallery, K. M. Rifat Faysal, Alex Kleinpeter, Miranda S. C. Wilson, Marina Vaysburd, Adam J. Fletcher, Mariia Novikova, Till Böcking, Eric O. Freed, Adolfo Saiardi, Leo C. James, "Cellular IP6 levels limit HIV production while viruses that cannot efficiently package IP6 are attenuated for infection and replication", Cell Reports, 29, 3983 - 3996.e4 (2019), DOI: 10.1016/j.celrep.2019.11.050
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