Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
106 items found for 2020 [total: 1243]
In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters Elife, 9 Dec 2020 DOI: 10.7554/eLife.64389
Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms Proceedings Of The National Academy Of Sciences, 118 Dec 2020 DOI: 10.1073/pnas.2024149118
Journal Paper I24-Microfocus Macromolecular Crystallography
Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein Elife, 9 Dec 2020 DOI: 10.7554/eLife.58242
Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose:glycoprotein glucosyltransferase Structure, Dec 2020 DOI: 10.1016/j.str.2020.11.017
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A new crystal form of the SARS-COV-2 receptor binding domain: CR3022 complex - an ideal target for in-crystal fragment screening of the ACE2 binding site surface Frontiers In Pharmacology, 11 Dec 2020 DOI: 10.3389/fphar.2020.615211
Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes Elife, 9 Dec 2020 DOI: 10.7554/eLife.62601
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins Nature Communications, 11 Dec 2020 DOI: 10.1038/s41467-020-18981-w
Structure of human RNA polymerase III Nature Communications, 11 Dec 2020 DOI: 10.1038/s41467-020-20262-5
Insights on the quest for the structure–function relationship of the mitochondrial pyruvate carrier Biology, 9 Nov 2020 DOI: 10.3390/biology9110407
Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target Proceedings Of The National Academy Of Sciences, 263 Nov 2020 DOI: 10.1073/pnas.2013620117
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance Journal Of Biological Chemistry, Nov 2020 DOI: 10.1074/jbc.RA120.016461
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Fluorescence anisotropy-based tethering for discovery of protein–protein interaction stabilizers Acs Chemical Biology, Nov 2020 DOI: 10.1021/acschembio.0c00646
Dimeric structure of the pseudokinase IRAK3 suggests an allosteric mechanism for negative regulation Structure, Nov 2020 DOI: 10.1016/j.str.2020.11.004
9.8 MAG: A new host lipid for in meso (lipid cubic phase) crystallization of integral membrane proteins Crystal Growth & Design, Nov 2020 DOI: 10.1021/acs.cgd.0c01301
Journal Paper I24-Microfocus Macromolecular Crystallography
The structure-function relationship of oncogenic LMTK3 Science Advances, 6 Nov 2020 DOI: 10.1126/sciadv.abc3099
Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition and inter-subunit electron transfer Journal Of Biological Chemistry, Nov 2020 DOI: 10.1074/jbc.RA120.016019
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The active site of magnesium chelatase Nature Plants, 104 Nov 2020 DOI: 10.1038/s41477-020-00806-9
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods Applied Microbiology And Biotechnology, 104 Nov 2020 DOI: 10.1007/s00253-020-10960-x
Modulation of amyloidogenic protein self-assembly using tethered small molecules Journal Of The American Chemical Society, Nov 2020 DOI: 10.1021/jacs.0c10629
Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ Nature Communications, 11 Oct 2020 DOI: 10.1038/s41467-020-18874-y
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1 Febs Letters, Oct 2020 DOI: 10.1002/1873-3468.13968
A new soaking procedure for X-ray crystallographic structural determination of protein–peptide complexes Acta Crystallographica Section F Structural Biology Communications, 76 Oct 2020 DOI: 10.1107/S2053230X2001122X
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and functional analysis of the inhibition of equine glutathione transferase A3-3 by organotin endocrine disrupting pollutants Environmental Pollution, Oct 2020 DOI: 10.1016/j.envpol.2020.115960
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Cannabidiol interactions with voltage-gated sodium channels Elife, 9 Oct 2020 DOI: 10.7554/eLife.58593
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Ascertaining the biochemical function of an essential pectin methylesterase in the gut microbe Bacteroides thetaiotaomicron Journal Of Biological Chemistry, Oct 2020 DOI: 10.1074/jbc.RA120.014974
Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major Plos Neglected Tropical Diseases, 14 Oct 2020 DOI: 10.1371/journal.pntd.0008762
Structural insights into Pseudomonas aeruginosa Type six secretion system exported effector 8 Journal Of Structural Biology, Oct 2020 DOI: 10.1016/j.jsb.2020.107651
Journal Paper I24-Microfocus Macromolecular Crystallography
Proposed allosteric inhibitors bind to the ATP site of CK2α Journal Of Medicinal Chemistry, Oct 2020 DOI: 10.1021/acs.jmedchem.0c01173
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Caffeine inhibits Notum activity by binding at the catalytic pocket Communications Biology, 3 Oct 2020 DOI: 10.1038/s42003-020-01286-5
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
MX at Diamond aids drug development for motor neurone disease Oct 2020
Science Highlight I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme Elife, 9 Sept 2020 DOI: 10.7554/eLife.61509
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis Ebiomedicine, 59 Sept 2020 DOI: 10.1016/j.ebiom.2020.102980
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Molecular recognition at septin interfaces: the switches hold the key Journal Of Molecular Biology, Sept 2020 DOI: 10.1016/j.jmb.2020.09.001
Dissecting the structural and functional roles of a putative metal entry site in encapsulated ferritins Journal Of Biological Chemistry, Sept 2020 DOI: 10.1074/jbc.RA120.014502
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex Nucleic Acids Research, 17 Sept 2020 DOI: 10.1093/nar/gkaa772
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of the human cation-independent mannose 6-phosphate/IGF2 receptor domains 7–11 uncovers the mannose 6-phosphate binding site of domain 9 Structure, Sept 2020 DOI: 10.1016/j.str.2020.08.002
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystal structure of Leishmania mexicana cysteine protease B in complex with a highly potent azadipeptide nitrile inhibitor Bioorganic & Medicinal Chemistry, Sept 2020 DOI: 10.1016/j.bmc.2020.115743
Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila Nature Communications, 11 Sept 2020 DOI: 10.1038/s41467-020-18696-y
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
High-throughput in situ experimental phasing Acta Crystallographica Section D Structural Biology, 76 Aug 2020 DOI: 10.1107/S2059798320009109
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Two-step release of kinase autoinhibition in discoidin domain receptor 1 Proceedings Of The National Academy Of Sciences, 63 Aug 2020 DOI: 10.1073/pnas.2007271117
Journal Paper I24-Microfocus Macromolecular Crystallography
Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown Nature Communications, 11 Aug 2020 DOI: 10.1038/s41467-020-17847-5
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structural characterization of anti-CCL5 activity of the tick salivary protein Evasin-4 Journal Of Biological Chemistry, Aug 2020 DOI: 10.1074/jbc.RA120.013891
Fragment based protein‐protein interaction stabilizers via imine‐based tethering Angewandte Chemie International Edition, Aug 2020 DOI: 10.1002/anie.202008585
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Stereoselective synthesis of allele-specific BET inhibitors Organic & Biomolecular Chemistry, 2 Aug 2020 DOI: 10.1039/D0OB01165G
Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle Journal Of Cell Biology, 219 Jul 2020 DOI: 10.1083/jcb.201910059
Screening of a custom-designed acid fragment library identifies 1-phenylpyrroles and 1-phenylpyrrolidines as inhibitors of Notum carboxylesterase activity Journal Of Medicinal Chemistry, Jul 2020 DOI: 10.1021/acs.jmedchem.0c00660
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Serial and single crystal studies of ligand binding to radiation sensitive haem protein DHP-B Jul 2020
Thesis I24-Microfocus Macromolecular Crystallography
Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria Journal Of Biological Chemistry, Jul 2020 DOI: 10.1074/jbc.RA120.014454
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems Science Advances, 6 Jul 2020 DOI: 10.1126/sciadv.abb6651
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural evidence for a reaction intermediate mimic in the active site of a sulfite dehydrogenase Chemical Communications, 114 Jul 2020 DOI: 10.1039/D0CC03634J
Small molecule AZD4635 inhibitor of A 2A R signaling rescues immune cell function including CD103 + dendritic cells enhancing anti-tumor immunity Journal For Immunotherapy Of Cancer, 8 Jul 2020 DOI: 10.1136/jitc-2019-000417
Timeless couples G‐quadruplex detection with processing by DDX 11 helicase during DNA replication The Embo Journal, 14 Jul 2020 DOI: 10.15252/embj.2019104185
Effects of 2-monoacylglycerol on in meso crystallization and the crystal structures of integral membrane proteins Crystal Growth & Design, Jul 2020 DOI: 10.1021/acs.cgd.0c00660
Journal Paper I24-Microfocus Macromolecular Crystallography
Development of serial crystallography methods for synchrotrons and x-ray free-electron lasers Jul 2020
Thesis I24-Microfocus Macromolecular Crystallography
X-ray induced photoreduction of heme metal centers rapidly induces active site perturbations in a protein-independent manner Journal Of Biological Chemistry, Jul 2020 DOI: 10.1074/jbc.RA120.014087
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase Journal Of Lipid Research, Jul 2020 DOI: 10.1194/jlr.RA120000993
X‐ray crystallography and free energy calculations reveal the binding mechanism of A2A adenosine receptor antagonists Angewandte Chemie International Edition, Jul 2020 DOI: 10.1002/anie.202003788
Structural basis of semaphorin‐plexin cis interaction The Embo Journal, 58 June 2020 DOI: 10.15252/embj.2019102926
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Mining the PDB for tractable cases where X-ray crystallography combined with fragment screens can be used to systematically design protein-protein inhibitors. Two test cases illustrated by IL1β-IL1R and p38α-TAB1 complexes Journal Of Medicinal Chemistry, June 2020 DOI: 10.1021/acs.jmedchem.0c00403
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis Nature Communications, 11 June 2020 DOI: 10.1038/s41467-020-16983-2
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Identification and characterization of diverse OTU deubiquitinases in bacteria The Embo Journal, 81 June 2020 DOI: 10.15252/embj.2020105127
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target Journal Of Biological Chemistry, June 2020 DOI: 10.1074/jbc.RA120.013695
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification Nucleic Acids Research, 6 June 2020 DOI: 10.1093/nar/gkaa539
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release Nature Communications, 11 June 2020 DOI: 10.1038/s41467-020-16586-x
Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
An evolutionary path to altered cofactor specificity in a metalloenzyme Nature Communications, 11 June 2020 DOI: 10.1038/s41467-020-16478-0
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Bicyclic boronates as potent inhibitors of AmpC, the class C β-Lactamase from Escherichia coli Biomolecules, 10 June 2020 DOI: 10.3390/biom10060899
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure and ligand-induced folding of the SAM/SAH riboswitch Nucleic Acids Research, 78 June 2020 DOI: 10.1093/nar/gkaa493
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure-based drug discovery of...(HTL22562): a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine Journal Of Medicinal Chemistry, June 2020 DOI: 10.1021/acs.jmedchem.0c01003
Journal Paper I24-Microfocus Macromolecular Crystallography
Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12 Open Biology, 10 June 2020 DOI: 10.1098/rsob.200041
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A transmembrane crenarchaeal mannosyltransferase is involved in N-glycan biosynthesis and displays an unexpected minimal cellulose-synthase-like fold Journal Of Molecular Biology, June 2020 DOI: 10.1016/j.jmb.2020.06.016
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Methionine adenosyltransferase structure and function studies: the novel role of a gating loop and a disease-causing residue in enzyme catalysis June 2020
Thesis I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion Chemical Science, May 2020 DOI: 10.1039/D0SC01232G
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers Life Science Alliance, 3 May 2020 DOI: 10.26508/lsa.202000725
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface Iucrj, 7 May 2020 DOI: 10.1107/S2052252520002973
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Scanning electron microscopy as a method for sample visualization in protein X-ray crystallography Iucrj, 7 May 2020 DOI: 10.1107/S2052252520003875
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Protein-protein interactions involved in copper homeostasis, oxidative aging and neurodegenerative disease May 2020 DOI: 10.11606/T.75.2020.tde-20052020-145630
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold European Journal Of Medicinal Chemistry, May 2020 DOI: 10.1016/j.ejmech.2020.112417
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Resistance to the “last resort” antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes Chemical Communications, 35 May 2020 DOI: 10.1039/D0CC02520H
Journal Paper I24-Microfocus Macromolecular Crystallography
Diphenylene iodonium is a non‐covalent MAO inhibitor: a biochemical and structural analysis Chemmedchem, May 2020 DOI: 10.1002/cmdc.202000264
Journal Paper I24-Microfocus Macromolecular Crystallography
Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine Biochemical Journal, 477 Apr 2020 DOI: 10.1042/BCJ20200128
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure and ligand binding of the ADP-binding domain of the NAD+ riboswitch Rna, Apr 2020 DOI: 10.1261/rna.074898.120
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Reverse protein engineering of a novel 4-domain copper nitrite reductase reveals functional regulation by protein-protein interaction The Febs Journal, Apr 2020 DOI: 10.1111/febs.15324
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
A lower X-gate in TASK channels traps inhibitors within the vestibule Nature, 18 Apr 2020 DOI: 10.1038/s41586-020-2250-8
Journal Paper I24-Microfocus Macromolecular Crystallography
Drosophila OTK is a glycosaminoglycan-binding protein with high conformational flexibility Structure, Mar 2020 DOI: 10.1016/j.str.2020.02.008
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The predictive power of data-processing statistics Iucrj, 7 Mar 2020 DOI: 10.1107/S2052252520000895
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
3-Oxo-β-sultam as a sulfonylating chemotype for inhibition of serine hydrolases and activity-based protein profiling Acs Chemical Biology, Mar 2020 DOI: 10.1021/acschembio.0c00090
NAG‐thiazoline is a potent inhibitor of the Vibrio campbellii GH20 β ‐ N ‐Acetylglucosaminidase The Febs Journal, Mar 2020 DOI: 10.1111/febs.15283
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization Acta Crystallographica Section F Structural Biology Communications, 76 Mar 2020 DOI: 10.1107/S2053230X20001466
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Engineering antibodies to treat cystic fibrosis Mar 2020
Science Highlight I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides Nature Communications, 11 Feb 2020 DOI: 10.1038/s41467-020-14754-7
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq Acta Crystallographica Section F Structural Biology Communications, 76 Feb 2020 DOI: 10.1107/S2053230X20001181
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation Nature, Feb 2020 DOI: 10.1038/s41586-020-2013-6
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Iron biomineral growth from the initial nucleation seed in L‐ferritin Chemistry – A European Journal, Feb 2020 DOI: 10.1002/chem.202000064
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase Nature Communications, 11 Feb 2020 DOI: 10.1038/s41467-020-14794-z
Elucidation of an allosteric mode‐of‐action for a thienopyrazole RORγt inverse agonist Chemmedchem, Feb 2020 DOI: 10.1002/cmdc.202000044
Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus Biochimica Et Biophysica Acta (bba) - General Subjects, Jan 2020 DOI: 10.1016/j.bbagen.2020.129521
Journal Paper I24-Microfocus Macromolecular Crystallography
Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin Nature Communications, 11 Jan 2020 DOI: 10.1038/s41467-019-13724-y
Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus Nature Communications, 11 Jan 2020 DOI: 10.1038/s41467-020-14509-4
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Measuring energy-dependent photoelectron escape in microcrystals Iucrj, 7 Jan 2020 DOI: 10.1107/S2052252519016178
Dynamic structural changes accompany the production of dihydroxypropanesulfonate by sulfolactaldehyde reductase Acs Catalysis, Jan 2020 DOI: 10.1021/acscatal.9b04427
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity Science Advances, 6 Jan 2020 DOI: 10.1126/sciadv.aax8286
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3 Nature Chemical Biology, 44 Jan 2020 DOI: 10.1038/s41589-019-0444-x
Journal Paper I24-Microfocus Macromolecular Crystallography
Chain alignment of collagen I deciphered using computationally designed heterotrimers Nature Chemical Biology, 27 Jan 2020 DOI: 10.1038/s41589-019-0435-y
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity Nature, 577 Jan 2020 DOI: 10.1038/s41586-019-1909-5
Journal Paper I24-Microfocus Macromolecular Crystallography
The biosynthetic pathway of the benzoxazole in nataxazole proceeds via an unstable ester and has synthetic utility Angewandte Chemie International Edition, Jan 2020 DOI: 10.1002/anie.201915685
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
- Inda Setyawati, Weronika K Stanek, Maria Majsnerowska, Lotteke J. Y. M. Swier, Els Pardon, Jan Steyaert, Albert Guskov, Dirk J. Slotboom, "In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters", Elife, 9 (2020), DOI: 10.7554/eLife.64389
- Xu Xiao, Youngjae Kim, Beatriz Romartinez-Alonso, Kristupas Sirvydis, Daniel S. Ory, John W. R. Schwabe, Michael E. Jung, Peter Tontonoz, "Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms", Proceedings Of The National Academy Of Sciences, 118 (2020), DOI: 10.1073/pnas.2024149118
- Ilona Rissanen, Robert Stass, Stefanie A. Krumm, Jeffrey Seow, Ruben J. G. Hulswit, Guido C. Paesen, Jussi Hepojoki, Olli Vapalahti, Åke Lundkvist, Olivier Reynard, Viktor Volchkov, Katie J Doores, Juha T. Huiskonen, Thomas A. Bowden, "Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein", Elife, 9 (2020), DOI: 10.7554/eLife.58242
- Carlos P. Modenutti, Juan I. Blanco Capurro, Roberta Ibba, Dominic S. Alonzi, Mauro N. Song, Snežana Vasiljević, Abhinav Kumar, Anu V. Chandran, Gabor Tax, Lucia Marti, Johan C. Hill, Andrea Lia, Mario Hensen, Thomas Waksman, Jonathan Rushton, Simone Rubichi, Angelo Santino, Marcelo A. Martí, Nicole Zitzmann, Pietro Roversi, "Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose:glycoprotein glucosyltransferase", Structure (2020), DOI: 10.1016/j.str.2020.11.017
- Charlie Nichols, Joseph Ng, Annika Keshu, Franca Fraternali, Gian F. De Nicola, "A new crystal form of the SARS-COV-2 receptor binding domain: CR3022 complex - an ideal target for in-crystal fragment screening of the ACE2 binding site surface", Frontiers In Pharmacology, 11 (2020), DOI: 10.3389/fphar.2020.615211
- Steffen Preissler, Claudia Rato, Yahui Yan, Luke A. Perera, Aron Czako, David Ron, "Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes", Elife, 9 (2020), DOI: 10.7554/eLife.62601
- Kathrin Nowak, Florian Rosenthal, Tobias Karlberg, Mareike Bütepage, Ann-Gerd Thorsell, Birgit Dreier, Jonas Grossmann, Jens Sobek, Ralph Imhof, Bernhard Lüscher, Herwig Schüler, Andreas Plückthun, Deena M. Leslie Pedrioli, Michael O. Hottiger, "Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins", Nature Communications, 11 (2020), DOI: 10.1038/s41467-020-18981-w
- Ewan Phillip Ramsay, Guillermo Abascal-Palacios, Julia L. Daiß, Helen King, Jerome Gouge, Michael Pilsl, Fabienne Beuron, Edward Morris, Philip Gunkel, Christoph Engel, Alessandro Vannini, "Structure of human RNA polymerase III", Nature Communications, 11 (2020), DOI: 10.1038/s41467-020-20262-5
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- Andrew Bell, Emmanuele Severi, Micah O. Lee, Serena Monaco, Dimitrios Latousakis, Jesus Angulo, Gavin H. Thomas, James Naismith, Nathalie Juge, "Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria", Journal Of Biological Chemistry (2020), DOI: 10.1074/jbc.RA120.014454
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- Anna Barwinska-Sendra, Yuritzi M. Garcia, Kacper M. Sendra, Arnaud Basle, Eilidh S. Mackenzie, Emma Tarrant, Patrick Card, Leandro C. Tabares, Cédric Bicep, Sun Un, Thomas E. Kehl-Fie, Kevin J. Waldron, "An evolutionary path to altered cofactor specificity in a metalloenzyme", Nature Communications, 11 (2020), DOI: 10.1038/s41467-020-16478-0
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- Sarah J. Bucknell, Mark A. Ator, Alastair Brown, Jason Brown, Andrew Cansfield, Julie Cansfield, John Christopher, Miles Congreve, Gabriella Cseke, Francesca Deflorian, Christopher Jones, Jonathan S. Mason, Alistair O'Brien, Gregory R. Ott, Mark Pickworth, Stacey Southall, "Structure-based drug discovery of...(HTL22562): a calcitonin gene-related peptide (CGRP) receptor antagonist for acute treatment of migraine", Journal Of Medicinal Chemistry (2020), DOI: 10.1021/acs.jmedchem.0c01003
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- Sarah L. Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph Mcloughlin, Tobias Krojer, Anthony Aimon, Anthony Bradley, Michael Fairhead, Paul Brear, Laura Diaz-Saez, Katherine Mcauley, Hannah F. Sore, Andrew Madin, Daniel H. O'Donovan, Kilian Huber, Marko Hyvonen, Frank Von Delft, Christopher G. Dowson, David R. Spring, "Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion", Chemical Science (2020), DOI: 10.1039/D0SC01232G
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- Danielle Karoline Silva Do Vale Castro, Sabrina Matos De Oliveira Da Silva, Humberto D'Muniz Pereira, Joci Neuby Alves Macedo, Diego Antonio Leonardo, Napoleao Fonseca Valadares, Patricia Suemy Kumagai, Jose Brandao-Neto, Ana Paula Ulian Araújo, Richard Charles Garratt, "A complete compendium of crystal structures for the human SEPT3 subgroup reveals functional plasticity at a specific septin interface", Iucrj, 7 (2020), DOI: 10.1107/S2052252520002973
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- Matthew J. Byrne, Nazia Nasir, Christine Basmadjian, Chitra Bhatia, Rory F. Cunnison, Katherine H. Carr, Corine Mas-Droux, Sharon Yeoh, Céline Cano, Richard Bayliss, "Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine", Biochemical Journal, 477, 1525 - 1539 (2020), DOI: 10.1042/BCJ20200128
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