Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I24 Contact
Beamline Phone Number:
+44 (0) 1235 778950
Principal Beamline Scientist:
Robin Owen
Tel: +44 (0) 1235 778522
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I24 Microfocus MX
Status: Operational
Beamsize: 5x5 - 50x40 (variable aspect ratio)
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
Detector: Pilatus3 6M
Wavelength: 0.62Å - 1.77Å
These publications are based on data gathered on beamline I24. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
88 items found for 2016 [total: 1243]
Structural basis for regulation and specificity of fructooligosaccharide import in Streptococcus pneumoniae Structure, Dec 2016 DOI: 10.1016/j.str.2016.11.008
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Contribution of shape and charge to the inhibition of a family GH99 endo -α-1,2-mannanase Journal Of The American Chemical Society, Dec 2016 DOI: 10.1021/jacs.6b10075
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for potency and promiscuity in poly(ADP-ribose) polymerase (PARP) and tankyrase inhibitors Journal Of Medicinal Chemistry, Dec 2016 DOI: 10.1021/acs.jmedchem.6b00990
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
RET functions as a dual-specificity kinase that requires allosteric inputs from juxtamembrane elements Cell Reports, 17 Dec 2016 DOI: 10.1016/j.celrep.2016.11.061
Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM Nucleic Acids Research, 44 Dec 2016 DOI: 10.1093/nar/gkw637
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and functional characterization of the phosphoglucomutase from Xanthomonas citri subsp. citri Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, 1864 Dec 2016 DOI: 10.1016/j.bbapap.2016.08.014
Journal Paper I24-Microfocus Macromolecular Crystallography
Structure and lipid binding properties of the kindlin-3 pleckstrin homology domain Biochemical Journal, Dec 2016 DOI: 10.1042/BCJ20160791
Intracellular allosteric antagonism of the CCR9 receptor Nature, 540 Dec 2016 DOI: 10.1038/nature20606
Journal Paper I24-Microfocus Macromolecular Crystallography
Structures of type IV pilins from Thermus thermophilus demonstrate similarities with type II secretion system pseudopilins Journal Of Structural Biology, 196 Dec 2016 DOI: 10.1016/j.jsb.2016.08.006
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD Bmc Biology, 14 Dec 2016 DOI: 10.1186/s12915-016-0300-3
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
First evidence of novel binding site on immune system protein Dec 2016
Science Highlight I24-Microfocus Macromolecular Crystallography
Drug discovery goes intracellular Dec 2016
Science Highlight I24-Microfocus Macromolecular Crystallography
Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl carbasugars Angewandte Chemie International Edition, 55 Nov 2016 DOI: 10.1002/anie.201607431
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Engineering archeal surrogate systems for the development of protein–protein interaction inhibitors against human RAD51 Journal Of Molecular Biology, 428 Nov 2016 DOI: 10.1016/j.jmb.2016.10.009
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms Scientific Reports, 6 Oct 2016 DOI: 10.1038/srep34701
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structure of the bacterial plant-ferredoxin receptor FusA Nature Communications, 7 Oct 2016 DOI: 10.1038/ncomms13308
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Ligand-bound structures and site-directed mutagenesis identify the acceptor and secondary binding sites of streptomyces coelicolor maltosyltransferase GlgE* Journal Of Biological Chemistry, 291 Oct 2016 DOI: 10.1074/jbc.M116.748160
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region Journal Of Structural Biology, 195 Sept 2016 DOI: 10.1016/j.jsb.2016.07.007
The inosine monophosphate dehydrogenase, GuaB2, is a vulnerable new bactericidal drug target for tuberculosis Acs Infectious Diseases, Sept 2016 DOI: 10.1021/acsinfecdis.6b00102
Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I Open Biology, 6 Sept 2016 DOI: 10.1098/rsob.160114
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Exploring the active site of the Streptococcus pneumoniae topoisomerase IV–DNA cleavage complex with novel 7,8-bridged fluoroquinolones Open Biology, 6 Sept 2016 DOI: 10.1098/rsob.160157
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization Developmental Cell, 38 Aug 2016 DOI: 10.1016/j.devcel.2016.07.018
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Exploiting microbeams for membrane protein structure determination Aug 2016 DOI: 10.1007/978-3-319-35072-1_8
Structural insights into cardiolipin transfer from the Inner membrane to the outer membrane by PbgA in Gram-negative bacteria Scientific Reports, 6 Aug 2016 DOI: 10.1038/srep30815
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The mechanism by which arabinoxylanases can recognise highly decorated xylans Journal Of Biological Chemistry, Aug 2016 DOI: 10.1074/jbc.M116.743948
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structural and functional basis for lipid synergy on the activity of the antibacterial peptide ABC transporter McjD Journal Of Biological Chemistry, Aug 2016 DOI: 10.1074/jbc.M116.732107
Structural and functional basis of protein phosphatase 5 substrate specificity Proceedings Of The National Academy Of Sciences, 113 Aug 2016 DOI: 10.1073/pnas.1603059113
Mutation-induced population shift in the MexR conformational ensemble disengages DNAbinding: a novel mechanism for MarR family derepression Structure, 24 Aug 2016 DOI: 10.1016/j.str.2016.06.008
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural basis for plexin activation and regulation Neuron, 91 Aug 2016 DOI: 10.1016/j.neuron.2016.06.018
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Biochemical and biophysical characterization of specific proteins involved in Trypanosoma brucei SL trans-splicing Aug 2016 DOI: 10.11606/T.76.2016.tde-21102016-160603
Thesis I24-Microfocus Macromolecular Crystallography
A new family of copper storage proteins discovered in methaneoxidising bacteria Aug 2016
Diamond Annual Review Highlight I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
How ion channels sense changes in their membrane environment and are inhibited by drugs Aug 2016
Diamond Annual Review Highlight I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome Elife, 5 Jul 2016 DOI: 10.7554/eLife.16413
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site Proceedings Of The National Academy Of Sciences, 113 Jul 2016 DOI: 10.1073/pnas.1600630113
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of the adenosine A2A receptor bound to an engineered G protein Nature, 536 Jul 2016 DOI: 10.1038/nature18966
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural basis of Smoothened regulation by its extracellular domains Nature, 535 Jul 2016 DOI: 10.1038/nature18934
Controlling the dissociation of ligands from the adenosine A2A receptor through modulation of salt bridge strength Journal Of Medicinal Chemistry, 59 Jul 2016 DOI: 10.1021/acs.jmedchem.6b00653
The structure of HIV-1 Rev filaments suggests a bilateral model for Rev-RRE assembly Structure, 24 Jul 2016 DOI: 10.1016/j.str.2016.04.015
Crystal structure and analysis of HdaB: The enteroaggregative Escherichia coli AAF/IV pilus tip protein Protein Science, Jul 2016 DOI: 10.1002/pro.2982
Structure and activation of pro-activin A Nature Communications, 7 Jul 2016 DOI: 10.1038/ncomms12052
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for integration of GluD receptors within synaptic organizer complexes Science, 353 Jul 2016 DOI: 10.1126/science.aae0104
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Installing hydrolytic activity into a completely de novo protein framework Nature Chemistry, 8 Jul 2016 DOI: 10.1038/nchem.2555
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections Scientific Reports, 6 Jul 2016 DOI: 10.1038/srep29179
Understanding chromatin regulators Jul 2016
Science Highlight B21-High Throughput SAXS I24-Microfocus Macromolecular Crystallography
Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes Proceedings Of The National Academy Of Sciences, 113 June 2016 DOI: 10.1073/pnas.1601368113
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Direct observation of DNA threading in flap endonuclease complexes Nature Structural & Molecular Biology, 23 June 2016 DOI: 10.1038/nsmb.3241
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A critical base pair in k-turns determines the conformational class adopted, and correlates with biological function Nucleic Acids Research, 44 June 2016 DOI: 10.1093/nar/gkw201
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Bacterial β-glucosidase reveals the structural and functional basis of genetic defects in human glucocerebrosidase 2 (GBA2) Acs Chemical Biology, May 2016 DOI: 10.1021/acschembio.6b00192
A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state Nature Communications, 7 May 2016 DOI: 10.1038/ncomms11673
Genetic analysis of Physcomitrella patens identifies ABSCISIC ACID NON-RESPONSIVE (ANR), a regulator of ABA responses unique to basal land plants and required for desiccation tolerance The Plant Cell, May 2016 DOI: 10.1105/tpc.16.00091
Exploiting protein conformational change to optimize adenosine-derived inhibitors of HSP70 Journal Of Medicinal Chemistry, May 2016 DOI: 10.1021/acs.jmedchem.5b02001
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development Open Biology, 6 May 2016 DOI: 10.1098/rsob.160053
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity Journal Of Clinical Investigation, 126 May 2016 DOI: 10.1172/JCI85679
Journal Paper B23-Circular Dichroism I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structure of human Cdc45 and implications for CMG helicase function Nature Communications, 7 May 2016 DOI: 10.1038/ncomms11638
The catalytic mechanism of a natural Diels–Alderase revealed in molecular detail Journal Of The American Chemical Society, 138 May 2016 DOI: 10.1021/jacs.6b00232
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structural investigation of the STAR protein Sam68 May 2016
Thesis I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Super-complexes of adhesion GPCRs and neural guidance receptors Nature Communications, 7 Apr 2016 DOI: 10.1038/ncomms11184
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex Acta Crystallographica Section D Structural Biology, 72 Apr 2016 DOI: 10.1107/S2059798316001212
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structures and binding dynamics of odorant-binding protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri Scientific Reports, 6 Apr 2016 DOI: 10.1038/srep24739
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Insights into the activation mechanism of class I HDAC complexes by inositol phosphates Nature Communications, Apr 2016 DOI: 10.1038/ncomms11262
Applications of thin-film sandwich crystallization platforms Acta Crystallographica Section F Structural Biology Communications, 72 (4) Apr 2016 DOI: 10.1107/S2053230X16004386
Rapid discovery of pyrido[3,4- d ]pyrimidine inhibitors of monopolar spindle kinase 1 (MPS1) using a structure-based hybridization approach Journal Of Medicinal Chemistry, Apr 2016 DOI: 10.1021/acs.jmedchem.5b01811
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The crystal structure of human dopamine β-hydroxylase at 2.9 A resolution Science Advances, 2 Apr 2016 DOI: 10.1126/sciadv.1500980
Journal Paper I02-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of the vanadate-inhibited Ca2+-ATPase Structure, 24 Apr 2016 DOI: 10.1016/j.str.2016.02.018
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural basis for Mep2 ammonium transceptor activation by phosphorylation Nature Communications, 7 Apr 2016 DOI: 10.1038/ncomms11337
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of Thermobifida fusca DyP-type peroxidase and activity towards Kraft lignin and lignin model compounds Archives Of Biochemistry And Biophysics, 594 Mar 2016 DOI: 10.1016/j.abb.2016.02.019
Fragment-based approaches to the development of Mycobacterium tuberculosis CYP121 inhibitors Journal Of Medicinal Chemistry, Mar 2016 DOI: 10.1021/acs.jmedchem.6b00007
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Radiation damage and derivatization in macromolecular crystallography: a structure factor's perspective Acta Crystallographica Section D Structural Biology, 72 (3) Mar 2016 DOI: 10.1107/S2059798315021555
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The structure of the core NuRD repression complex provides insights into its interaction with chromatin Elife, Mar 2016 DOI: 10.7554/eLife.13941
Novel actin filaments from Bacillus thuringiensis form nanotubules for plasmid DNA segregation Proceedings Of The National Academy Of Sciences, 113 Mar 2016 DOI: 10.1073/pnas.1600129113
World's first dual topology channel Mar 2016
Science Highlight I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. family GH3 β- D -glucosidases Acta Crystallographica Section D Structural Biology, 72 Feb 2016 DOI: 10.1107/S2059798315024237
Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters Nature Structural & Molecular Biology, Feb 2016 DOI: 10.1038/nsmb.3164
Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization Embo Reports, 17 (3) Feb 2016 DOI: 10.15252/embr.201541520
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
The light chains of kinesin-1 are autoinhibited Proceedings Of The National Academy Of Sciences, 113 (9) Feb 2016 DOI: 10.1073/pnas.1520817113
Journal Paper I24-Microfocus Macromolecular Crystallography
A structure-guided switch in the regioselectivity of a tryptophan halogenase Chembiochem, 9 Feb 2016 DOI: 10.1002/cbic.201600051
Structures of two melanoma-associated antigens suggest allosteric regulation of effector binding Plos One, 11 Feb 2016 DOI: 10.1371/journal.pone.0148762
Journal Paper B21-High Throughput SAXS I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase Chemical Science, Feb 2016 DOI: 10.1039/C6SC00370B
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin Science, 351 (6275) Feb 2016 DOI: 10.1126/science.aad3747
Journal Paper I24-Microfocus Macromolecular Crystallography
Mechanism of DNA loading by the DNA repair helicase XPD Nucleic Acids Research, 44 Feb 2016 DOI: 10.1093/nar/gkw102
Structural basis of outer membrane protein insertion by the BAM complex Nature, 531 Feb 2016 DOI: 10.1038/nature17199
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystal structure of an engineered LRRTM2 synaptic adhesion molecule and a model for neurexin binding Biochemistry, 55 (6) Feb 2016 DOI: 10.1021/acs.biochem.5b00971
Journal Paper I24-Microfocus Macromolecular Crystallography
Traceable atomic force microscopy of high-quality solvent-free crystals of [6,6]-phenyl-C61-butyric acid methyl ester Applied Physics Letters, 108 Feb 2016 DOI: 10.1063/1.4941227
Journal Paper I24-Microfocus Macromolecular Crystallography
Imperfection and radiation damage in protein crystals studied with coherent radiation Journal Of Synchrotron Radiation, 23 Jan 2016 DOI: 10.1107/S1600577515019700
The crystal structure of Z-(Aib)10-OH at 0.65 Å resolution: three complete turns of 310-helix Journal Of Peptide Science, 22 Jan 2016 DOI: 10.1002/psc.2842
Journal Paper I24-Microfocus Macromolecular Crystallography
Structural insights into polymorphic abo glycan binding by Helicobacter pylori Cell Host & Microbe, 19 Jan 2016 DOI: 10.1016/j.chom.2015.12.004
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Targeted protein adsorption on the surface of biomaterials Jan 2016
Thesis I24-Microfocus Macromolecular Crystallography open access
Structural basis of substrate specificity in porcine RNase 4 Febs Journal, Jan 2016 DOI: 10.1111/febs.13646
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
- Simone Culurgioni, Gemma Harris, Anirudh K. Singh, Samantha J. King, Martin A. Walsh, "Structural basis for regulation and specificity of fructooligosaccharide import in Streptococcus pneumoniae", Structure (2016), DOI: 10.1016/j.str.2016.11.008
- Marija Petricevic, Lukasz F. Sobala, Pearl Fernandes, Lluís Raich, Andrew James Thompson, Ganeko Bernardo-Seisdedos, Oscar Millet, Sha Zhu, Matthieu Sollogoub, Jesús Jimenez-Barbero, Carme Rovira, Gideon J. Davies, Spencer J. Williams, "Contribution of shape and charge to the inhibition of a family GH99 endo -α-1,2-mannanase", Journal Of The American Chemical Society (2016), DOI: 10.1021/jacs.6b10075
- Ann-Gerd Thorsell, Torun Ekblad, Tobias Karlberg, Mirjam Löw, Ana Filipa Pinto, Lionel Trésaugues, Martin Moche, Michael S. Cohen, Herwig Schüler, "Structural basis for potency and promiscuity in poly(ADP-ribose) polymerase (PARP) and tankyrase inhibitors", Journal Of Medicinal Chemistry (2016), DOI: 10.1021/acs.jmedchem.6b00990
- Ivan Plaza-Menacho, Karin Barnouin, Rachael Barry, Annabel Borg, Mariam Orme, Rakhee Chauhan, Stephane Mouilleron, Ruben J. Martinez-Torres, Pascal Meier, Neil Q. Mcdonald, "RET functions as a dual-specificity kinase that requires allosteric inputs from juxtamembrane elements", Cell Reports, 17, 3319 - 3332 (2016), DOI: 10.1016/j.celrep.2016.11.061
- Dhaval Varshney, Alain-Pierre Petit, Juan A. Bueren-Calabuig, Chimed Jansen, Dan A. Fletcher, Mark Peggie, Simone Weidlich, Paul Scullion, Andrei V. Pisliakov, Victoria H. Cowling, "Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM", Nucleic Acids Research, 44, 10423 - 10436 (2016), DOI: 10.1093/nar/gkw637
- Leandro Seiji Goto, André Vessoni Alexandrino, Camila Malvessi Pereira, Carla Silva Martins, Humberto D'Muniz Pereira, Jose Brandao-Neto, Maria Teresa Marques Novo-Mansur, "Structural and functional characterization of the phosphoglucomutase from Xanthomonas citri subsp. citri", Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, 1864, 1658 - 1666 (2016), DOI: 10.1016/j.bbapap.2016.08.014
- Tao Ni, Antreas Kalli, Fiona Naughton, Luke Yates, Omar Naneh, Mirijam Kozorog, Gregor Anderluh, Mark Sansom, Robert Gilbert, "Structure and lipid binding properties of the kindlin-3 pleckstrin homology domain", Biochemical Journal (2016), DOI: 10.1042/BCJ20160791
- Christine Oswald, Mathieu Rappas, James Kean, Andrew Dore, James C. Errey, Kirstie Bennett, Francesca Deflorian, John A. Christopher, Ali Jazayeri, Jonathan S. Mason, Miles Congreve, Robert M. Cooke, Fiona H. Marshall, "Intracellular allosteric antagonism of the CCR9 receptor", Nature, 540, 462 - 465 (2016), DOI: 10.1038/nature20606
- Vijaykumar Karuppiah, Angela Thistlethwaite, Jeremy P. Derrick, "Structures of type IV pilins from Thermus thermophilus demonstrate similarities with type II secretion system pseudopilins", Journal Of Structural Biology, 196, 375 – 384 (2016), DOI: 10.1016/j.jsb.2016.08.006
- Esben M. Quistgaard, Ulrich Weininger, Yonca Ural-Blimke, Kristofer Modig, Pär Nordlund, Mikael Akke, Christian Low, "Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD", Bmc Biology, 14 (2016), DOI: 10.1186/s12915-016-0300-3
- [Science Highlight] Diamond Light Source, "First evidence of novel binding site on immune system protein" (2016)
- [Science Highlight] Diamond Light Source, "Drug discovery goes intracellular" (2016)
- Christopher Adamson, Robert J. Pengelly, Saeideh Shamsi Kazem Abadi, Saswati Chakladar, Jason Draper, Robert Britton, Tracey M. Gloster, Andrew J. Bennet, "Structural snapshots for mechanism-based inactivation of a glycoside hydrolase by cyclopropyl carbasugars", Angewandte Chemie International Edition, 55, 14978 - 14982 (2016), DOI: 10.1002/anie.201607431
- Tommaso Moschetti, Timothy Sharpe, Gerhard Fischer, May E. Marsh, Hong Kin Ng, Matthew Morgan, Duncan E. Scott, Tom L. Blundell, Ashok R. Venkitaraman, John Skidmore, Chris Abell, Marko Hyvonen, "Engineering archeal surrogate systems for the development of protein–protein interaction inhibitors against human RAD51", Journal Of Molecular Biology, 428, 4589 - 4607 (2016), DOI: 10.1016/j.jmb.2016.10.009
- Alan M. Jones, Isaac M. Westwood, James D. Osborne, Thomas P. Matthews, Matthew D. Cheeseman, Martin G. Rowlands, Fiona Jeganathan, Rosemary Burke, Diane Lee, Nadia Kadi, Manjuan Liu, Meirion Richards, Craig Mcandrew, Norhakim Yahya, Sarah Dobson, Keith Jones, Paul Workman, Ian Collins, Rob L. M. Van Montfort, "A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms", Scientific Reports, 6 (2016), DOI: 10.1038/srep34701
- Rhys Grinter, Inokentijs Josts, Khedidja Mosbahi, Aleksander W. Roszak, Richard J. Cogdell, Alexandre M. J. J. Bonvin, Joel J. Milner, Sharon M. Kelly, Olwyn Byron, Brian O. Smith, Daniel Walker, "Structure of the bacterial plant-ferredoxin receptor FusA", Nature Communications, 7 (2016), DOI: 10.1038/ncomms13308
- Karl Syson, Clare E. M. Stevenson, Farzana Miah, J. Elaine Barclay, Minhong Tang, Andrii Gorelik, Abdul M. Rashid, David M. Lawson, Stephen Bornemann, "Ligand-bound structures and site-directed mutagenesis identify the acceptor and secondary binding sites of streptomyces coelicolor maltosyltransferase GlgE*", Journal Of Biological Chemistry, 291, 21531 - 21540 (2016), DOI: 10.1074/jbc.M116.748160
- Shintaro Aibara, Xiao-Chen Bai, Murray Stewart, "The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region", Journal Of Structural Biology, 195, 316 - 324 (2016), DOI: 10.1016/j.jsb.2016.07.007
- Vinayak Singh, Stefano Donini, Angela Pacitto, Claudia Sala, Ruben C. Hartkoorn, Neeraj Dhar, Gyorgy Keri, David B. Ascher, Guillaume Mondésert, Anthony Vocat, Andréanne Lupien, Raphael Sommer, Hélène Vermet, Sophie Lagrange, Joe Buechler, Digby F. Warner, John D. Mckinney, Janos Pato, Stewart T. Cole, Tom L. Blundell, Menico Rizzi, Valerie Mizrahi, "The inosine monophosphate dehydrogenase, GuaB2, is a vulnerable new bactericidal drug target for tuberculosis", Acs Infectious Diseases (2016), DOI: 10.1021/acsinfecdis.6b00102
- Julijus Bogomolovas, Jennifer R. Fleming, Brian R. Anderson, Rhys Williams, Stephan Lange, Bernd Simon, Muzamil M. Khan, Rüdiger Rudolf, Barbara Franke, Belinda Bullard, Daniel J. Rigden, Henk Granzier, Siegfried Labeit, Olga Mayans, "Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I", Open Biology, 6 (2016), DOI: 10.1098/rsob.160114
- Ivan Laponogov, Xiao-Su Pan, Dennis A. Veselkov, Ryan T. Cirz, Allan Wagman, Heinz E. Moser, L. Mark Fisher, Mark R. Sanderson, "Exploring the active site of the Streptococcus pneumoniae topoisomerase IV–DNA cleavage complex with novel 7,8-bridged fluoroquinolones", Open Biology, 6 (2016), DOI: 10.1098/rsob.160157
- Erika V. Soriano, Marina E. Ivanova, Georgina Fletcher, Philippe Riou, Phillip P. Knowles, Karin Barnouin, Andrew Purkiss, Brenda Kostelecky, Peter Saiu, Mark Linch, Ahmed Elbediwy, Svend Kjær, Nicola O’reilly, Ambrosius p. Snijders, Peter J. Parker, Barry J. Thompson, Neil q. Mcdonald, "aPKC inhibition by Par3 CR3 flanking regions controls substrate access and underpins apical-junctional polarization", Developmental Cell, 38, 384 - 398 (2016), DOI: 10.1016/j.devcel.2016.07.018
- [Book Chapter] Anna J. Warren, Danny Axford, Neil G. Paterson, Robin L. Owen, "Exploiting microbeams for membrane protein structure determination" (2016), DOI: 10.1007/978-3-319-35072-1_8
- Haohao Dong, Zhengyu Zhang, Xiaodi Tang, Shihai Huang, Huanyu Li, Bo Peng, Changjiang Dong, "Structural insights into cardiolipin transfer from the Inner membrane to the outer membrane by PbgA in Gram-negative bacteria", Scientific Reports, 6 (2016), DOI: 10.1038/srep30815
- Aurore Labourel, Lucy I. Crouch, Joana L. A. Brás, Adam Jackson, Artur Rogowski, Joseph Gray, Madhav P. Yadav, Bernard Henrissat, Carlos M. G. A. Fontes, Harry J. Gilbert, Shabir Najmudin, Arnaud Basle, Fiona Cuskin, "The mechanism by which arabinoxylanases can recognise highly decorated xylans", Journal Of Biological Chemistry (2016), DOI: 10.1074/jbc.M116.743948
- Shahid Mehmood, Valentina Corradi, Hassan Choudhury, Rohanah Hussain, Patrick Becker, Danny Axford, Severine Zirah, Sylvie Rebuffat, D. Peter Tieleman, Carol V. Robinson, Konstantinos Beis, "Structural and functional basis for lipid synergy on the activity of the antibacterial peptide ABC transporter McjD", Journal Of Biological Chemistry (2016), DOI: 10.1074/jbc.M116.732107
- Jasmeen Oberoi, Diana M. Dunn, Mark R. Woodford, Laura Mariotti, Jacqualyn Schulman, Dimitra Bourboulia, Mehdi Mollapour, Cara K. Vaughan, "Structural and functional basis of protein phosphatase 5 substrate specificity", Proceedings Of The National Academy Of Sciences, 113, 9009 - 9014 (2016), DOI: 10.1073/pnas.1603059113
- Madhanagopal Anandapadamanaban, Robert Pilstål, Cecilia Andresen, Jill Trewhella, Martin Moche, Björn Wallner, Maria Sunnerhagen, "Mutation-induced population shift in the MexR conformational ensemble disengages DNAbinding: a novel mechanism for MarR family derepression", Structure, 24, 1311 - 1321 (2016), DOI: 10.1016/j.str.2016.06.008
- Youxin Kong, Bert J. C. Janssen, Tomas Malinauskas, Vamshidhar r. Vangoor, Charlotte Coles, Rainer Kaufmann, Tao Ni, Robert J. C. Gilbert, Sergi Padilla-Parra, R. jeroen Pasterkamp, E. yvonne Jones, "Structural basis for plexin activation and regulation", Neuron, 91, 548 - 560 (2016), DOI: 10.1016/j.neuron.2016.06.018
- [Thesis] Ivan Rosa Silva, "Biochemical and biophysical characterization of specific proteins involved in Trypanosoma brucei SL trans-splicing" (2016), DOI: 10.11606/T.76.2016.tde-21102016-160603
- [Diamond Annual Review Highlight] Diamond Light Source, "A new family of copper storage proteins discovered in methaneoxidising bacteria" (2016)
- [Diamond Annual Review Highlight] Diamond Light Source, "How ion channels sense changes in their membrane environment and are inhibited by drugs" (2016)
- An Van Den Bossche, Steven Hardwick, Pieter-Jan Ceyssens, Hanne Hendrix, Marleen Voet, Tom Dendooven, Katarzyna J. Bandyra, Marc De Maeyer, Abram Aertsen, Jean-Paul Noben, Ben Luisi, Rob Lavigne, "Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome", Elife, 5 (2016), DOI: 10.7554/eLife.16413
- Monica Kasbekar, Gerhard Fischer, Bryan T. Mott, Adam Yasgar, Marko Hyvonen, Helena I. M. Boshoff, Chris Abell, Clifton E. Barry, Craig J. Thomas, "Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site", Proceedings Of The National Academy Of Sciences, 113, 7503 - 7508 (2016), DOI: 10.1073/pnas.1600630113
- Byron Carpenter, Rony Nehmé, Tony Warne, Andrew G. W. Leslie, Christopher G. Tate, "Structure of the adenosine A2A receptor bound to an engineered G protein", Nature, 536, 104 - 107 (2016), DOI: 10.1038/nature18966
- Eamon F. X. Byrne, Ria Sircar, Paul S. Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D. Tully, Laurel Mydock-Mcgrane, Douglas F. Covey, Robert P. Rambo, Mark S. P. Sansom, Simon Newstead, Rajat Rohatgi, Christian Siebold, "Structural basis of Smoothened regulation by its extracellular domains", Nature, 535, 517 - 522 (2016), DOI: 10.1038/nature18934
- Elena Segala, Dong Guo, Robert K. Y. Cheng, Andrea Bortolato, Francesca Deflorian, Andrew S. Doré, James C. Errey, Laura H. Heitman, Adriaan P. Ijzerman, Fiona H. Marshall, Robert M. Cooke, "Controlling the dissociation of ligands from the adenosine A2A receptor through modulation of salt bridge strength", Journal Of Medicinal Chemistry, 59, 6470 - 6479 (2016), DOI: 10.1021/acs.jmedchem.6b00653
- Mike Dimattia, Norman R. Watts, Naiqian Cheng, Rick Huang, J. Bernard Heymann, Jonathan Grimes, Paul T. Wingfield, David I. Stuart, Alasdair C. Steven, "The structure of HIV-1 Rev filaments suggests a bilateral model for Rev-RRE assembly", Structure, 24, 1068 - 1080 (2016), DOI: 10.1016/j.str.2016.04.015
- Wei-Chao Lee, Steve Matthews, James A. Garnett, "Crystal structure and analysis of HdaB: The enteroaggregative Escherichia coli AAF/IV pilus tip protein", Protein Science (2016), DOI: 10.1002/pro.2982
- Xuelu Wang, Gerhard Fischer, Marko Hyvonen, "Structure and activation of pro-activin A", Nature Communications, 7 (2016), DOI: 10.1038/ncomms12052
- Jonathan Elegheert, W. Kakegawa, J. Clay, N. F. Shanks, E. Behiels, K. Matsuda, K. Kohda, E. Miura, M. Rossmann, Nikolaos Mitakidis, J. Motohashi, Veronica T. Chang, Christian Siebold, Ingo H. Greger, Terunaga Nakagawa, M. Yuzaki, A. Radu Aricescu, "Structural basis for integration of GluD receptors within synaptic organizer complexes", Science, 353, 295 - 299 (2016), DOI: 10.1126/science.aae0104
- Antony J. Burton, Andrew R. Thomson, William M. Dawson, R. Leo Brady, Derek N. Woolfson, "Installing hydrolytic activity into a completely de novo protein framework", Nature Chemistry, 8, 837 - 844 (2016), DOI: 10.1038/nchem.2555
- Martin Mcphillie, Ying Zhou, Kamal El Bissati, Jitender Dubey, Hernan Lorenzi, Michael Capper, Amanda K. Lukens, Mark Hickman, Stephen Muench, Shiv Kumar Verma, Christopher R. Weber, Kelsey Wheeler, James Gordon, Justin Sanders, Hong Moulton, Kai Wang, Taek-Kyun Kim, Yuqing He, Tatiana Santos, Stuart Woods, Patty Lee, David Donkin, Eric Kim, Laura Fraczek, Joseph Lykins, Farida Esaa, Fatima Alibana-Clouser, Sarah Dovgin, Louis Weiss, Gael Brasseur, Dyann Wirth, Michael Kent, Leroy Hood, Brigitte Meunieur, Craig W. Roberts, S. Samar Hasnain, Svetlana V. Antonyuk, Colin Fishwick, Rima Mcleod, "New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections", Scientific Reports, 6 (2016), DOI: 10.1038/srep29179
- [Science Highlight] Diamond Light Source, "Understanding chromatin regulators" (2016)
- Philip Hinchliffe, Mariano M. González, Maria F. Mojica, Javier M. González, Valerie Castillo, Cecilia Saiz, Magda Kosmopoulou, Catherine Tooke, Leticia I. Llarrull, Graciela Mahler, Robert A. Bonomo, Alejandro J. Vila, Jim Spencer, "Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes", Proceedings Of The National Academy Of Sciences, 113, E3745 - E3754 (2016), DOI: 10.1073/pnas.1601368113
- Faizah Almalki, Claudia Flemming, Jing Zhang, Min Feng, Svetlana E Sedelnikova, Tom Ceska, J B Rafferty, Jon Sayers, P J Artymiuk, "Direct observation of DNA threading in flap endonuclease complexes", Nature Structural & Molecular Biology, 23, 640 - 646 (2016), DOI: 10.1038/nsmb.3241
- Lin Huang, Jia Wang, David Lilley, "A critical base pair in k-turns determines the conformational class adopted, and correlates with biological function", Nucleic Acids Research, 44, 5390 - 5398 (2016), DOI: 10.1093/nar/gkw201
- Ratana Charoenwattanasatien, Salila Pengthaisong, Imogen Breen, Risa Mutoh, Sompong Sansenya, Yanling Hua, Anupong Tankrathok, Liang Wu, Chomphunuch Songsiriritthigul, Hideaki Tanaka, Spencer J. Williams, Gideon Davies, Genji Kurisu, James R. Ketudat Cairns, "Bacterial β-glucosidase reveals the structural and functional basis of genetic defects in human glucocerebrosidase 2 (GBA2)", Acs Chemical Biology (2016), DOI: 10.1021/acschembio.6b00192
- Lina Malinauskaite, Saida Said, Caglanur Sahin, Julie Grouleff, Azadeh Shahsavar, Henriette Bjerregaard, Pernille Noer, Kasper Severinsen, Thomas Boesen, Birgit Schiøtt, Steffen Sinning, Poul Nissen, "A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state", Nature Communications, 7 (2016), DOI: 10.1038/ncomms11673
- Sean Ross Stevenson, Yasuko Kamisugi, Chi H. Hung Trinh, Jeremy Schmutz, Jerry W. Jenkins, Jane Grimwood, Wellington Muchero, Gerald A. Tuskan, Stefan A. Rensing, Daniel Lang, Ralf Reski, Michael Melkonian, Carl J. Rothfels, Fay-Wei Li, Anders Larsson, Gane Ka-Shu Wong, Thomas A. Edwards, Andrew C. Cuming, "Genetic analysis of Physcomitrella patens identifies ABSCISIC ACID NON-RESPONSIVE (ANR), a regulator of ABA responses unique to basal land plants and required for desiccation tolerance", The Plant Cell (2016), DOI: 10.1105/tpc.16.00091
- Matthew D. Cheeseman, Isaac Westwood, Olivier Barbeau, Martin Rowlands, Sarah Dobson, Alan M. Jones, Fiona Jeganathan, Rosemary Burke, Nadia Kadi, Paul Workman, Ian Collins, Rob Van Montfort, Keith Jones, "Exploiting protein conformational change to optimize adenosine-derived inhibitors of HSP70", Journal Of Medicinal Chemistry (2016), DOI: 10.1021/acs.jmedchem.5b02001
- Tao Ni, Karl Harlos, Robert J. C. Gilbert, "Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development", Open Biology, 6 (2016), DOI: 10.1098/rsob.160053
- David Cole, Anna Bulek, Garry Dolton, Andrea J. Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John Miles, Mark Peakman, Linda Wooldridge, Pierre Rizkallah, Andrew K. Sewell, "Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity", Journal Of Clinical Investigation, 126, 2191 - 2204 (2016), DOI: 10.1172/JCI85679
- Aline C. Simon, Vincenzo Sannino, Vincenzo Costanzo, Luca Pellegrini, "Structure of human Cdc45 and implications for CMG helicase function", Nature Communications, 7 (2016), DOI: 10.1038/ncomms11638
- Matthew J. Byrne, Nicholas R. Lees, Li-Chen Han, Marc W. Van Der Kamp, Adrian J. Mulholland, James E. M. Stach, Christine L. Willis, Paul R. Race, "The catalytic mechanism of a natural Diels–Alderase revealed in molecular detail", Journal Of The American Chemical Society, 138, 6095 - 6098 (2016), DOI: 10.1021/jacs.6b00232
- [Thesis] Jaelle Foot, "Structural investigation of the STAR protein Sam68" (2016)
- Verity A. Jackson, Shahid Mehmood, Matthieu Chavent, Pietro Roversi, Maria Carrasquero, Daniel Del Toro, Goenuel Seyit-Bremer, Fanomezana M. Ranaivoson, Davide Comoletti, Mark S. P. Sansom, Carol V. Robinson, Rüdiger Klein, Elena Seiradake, "Super-complexes of adhesion GPCRs and neural guidance receptors", Nature Communications, 7 (2016), DOI: 10.1038/ncomms11184
- Dennis Veselkov, Ivan Laponogov, Xiao-Su Pan, Jogitha Selvarajah, Galyna Skamrova, Arthur Branstrom, Jana Narasimhan, Josyula V. N. Vara Prasad, L. Mark Fisher, Mark Sanderson, "Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex", Acta Crystallographica Section D Structural Biology, 72, 488 - 496 (2016), DOI: 10.1107/S2059798316001212
- Tom Northey, Herbert Venthur, Filomena De Biasio, Francois Xavier Chauviac, Ambrose Cole, Karlos Antonio Lisboa Ribeiro, Gerarda Grossi, Patrizia Falabella, Linda M. Field, Nicholas H. Keep, Jing-Jiang Zhou, "Crystal structures and binding dynamics of odorant-binding protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri", Scientific Reports, 6 (2016), DOI: 10.1038/srep24739
- Peter Watson, Christopher Millard, Andrew Riley, Naomi Robertson, Lyndsey Wright, Himali Godage, Shaun Cowley, Andrew Jamieson, Barry Potter, John Schwabe, "Insights into the activation mechanism of class I HDAC complexes by inositol phosphates", Nature Communications (2016), DOI: 10.1038/ncomms11262
- Danny Axford, Pierre Aller, Juan Sanchez-Weatherby, James Sandy, "Applications of thin-film sandwich crystallization platforms", Acta Crystallographica Section F Structural Biology Communications, 72 (4), 313 - 319 (2016), DOI: 10.1107/S2053230X16004386
- Paolo Innocenti, Hannah L. Woodward, Savade Solanki, Sébastien Naud, Isaac Westwood, Nora Cronin, Angela Hayes, Jennie Roberts, Alan T. Henley, Ross Baker, Amir Faisal, Grace Wing-Yan Mak, Gary Box, Melanie Valenti, Alexis De Haven Brandon, Lisa O’ Fee, Harry Saville, Jessica Schmitt, Berry Matijssen, Rosemary Burke, Rob Van Montfort, Florence I. Raynaud, Suzanne A. Eccles, Spiros Linardopoulos, Julian Blagg, Swen Hoelder, "Rapid discovery of pyrido[3,4- d ]pyrimidine inhibitors of monopolar spindle kinase 1 (MPS1) using a structure-based hybridization approach", Journal Of Medicinal Chemistry (2016), DOI: 10.1021/acs.jmedchem.5b01811
- Trine Vammen Vendelboe, P. Harris, Yuguang Zhao, Thomas Walter, Karl Harlos, Kamel El Omari, Hans E. M. Christensen, "The crystal structure of human dopamine β-hydroxylase at 2.9 A resolution", Science Advances, 2, e1500980 - e1500980 (2016), DOI: 10.1126/sciadv.1500980
- Johannes d. Clausen, Maike Bublitz, Bertrand Arnou, Claus Olesen, Jens peter Andersen, Jesper Vuust Møller, Poul Nissen, "Crystal structure of the vanadate-inhibited Ca2+-ATPase", Structure, 24, 617 - 623 (2016), DOI: 10.1016/j.str.2016.02.018
- Bert Van Den Berg, Anupama Chembath, Damien Jefferies, Arnaud Basle, Syma Khalid, Julian C. Rutherford, "Structural basis for Mep2 ammonium transceptor activation by phosphorylation", Nature Communications, 7 (2016), DOI: 10.1038/ncomms11337
- Rahman Rahmanpour, Dean Rea, Shirin Jamshidi, Vilmos Fulop, Timothy D. H. Bugg, "Structure of Thermobifida fusca DyP-type peroxidase and activity towards Kraft lignin and lignin model compounds", Archives Of Biochemistry And Biophysics, 594, 54–60 (2016), DOI: 10.1016/j.abb.2016.02.019
- Madeline E. Kavanagh, Anthony G. Coyne, Kirsty J. Mclean, Guy G. James, Colin W. Levy, Leonardo B. Marino, Luiz Pedro S. De Carvalho, Daniel S. H. Chan, Sean A. Hudson, Sachin Surade, David Leys, Andrew W. Munro, Chris Abell, "Fragment-based approaches to the development of Mycobacterium tuberculosis CYP121 inhibitors", Journal Of Medicinal Chemistry (2016), DOI: 10.1021/acs.jmedchem.6b00007
- Robin Owen, Darren Sherrell, "Radiation damage and derivatization in macromolecular crystallography: a structure factor's perspective", Acta Crystallographica Section D Structural Biology, 72 (3), 388 - 394 (2016), DOI: 10.1107/S2059798315021555
- Christopher Millard, Nirajan Varma, Almutasem Saleh, Kyle Morris, Peter Watson, Andrew Bottrill, Louise Fairall, Corinne Smith, John Schwabe, "The structure of the core NuRD repression complex provides insights into its interaction with chromatin", Elife (2016), DOI: 10.7554/eLife.13941
- Shimin Jiang, Akihiro Narita, David Popp, Umesh Ghoshdastider, Lin Jie Lee, Ramanujam Srinivasan, Mohan K. Balasubramaniam, Toshiro Oda, Fujiet Koh, Mårten Larsson, Robert Robinson, "Novel actin filaments from Bacillus thuringiensis form nanotubules for plasmid DNA segregation", Proceedings Of The National Academy Of Sciences, 113, E1200 - E1205 (2016), DOI: 10.1073/pnas.1600129113
- [Science Highlight] Diamond Light Source, "World's first dual topology channel" (2016)
- Jon Agirre, Antonio Ariza, Wendy Offen, Johan Turkenburg, Shirley Roberts, Stuart Mcnicholas, Paul V. Harris, Brett Mc Brayer, Jan Dohnalek, Kevin Cowtan, Gideon Davies, Keith Wilson, "Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. family GH3 β- D -glucosidases", Acta Crystallographica Section D Structural Biology, 72, 254 - 265 (2016), DOI: 10.1107/S2059798315024237
- Mathieu Coincon, Povilas Uzdavinys, Emmanuel Nji, David L Dotson, Iven Winkelmann, Saba Abdul Hussein, Alexander D Cameron, Oliver Beckstein, David Drew, "Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters", Nature Structural & Molecular Biology (2016), DOI: 10.1038/nsmb.3164
- L. Subramanian, B. Medina - Pritchard, R. Barton, F. Spiller, R. Kulasegaran-Shylini, G. Radaviciute, R. C. Allshire, A. Arockia Jeyaprakash, "Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization", Embo Reports, 17 (3), 279 - 469 (2016), DOI: 10.15252/embr.201541520
- Yan Y. Yip, Stefano Pernigo, Anneri Sanger, Mengjia Xu, Maddy Parsons, Roberto Steiner, Mark P. Dodding, "The light chains of kinesin-1 are autoinhibited", Proceedings Of The National Academy Of Sciences, 113 (9) (2016), DOI: 10.1073/pnas.1520817113
- Sarah Ann Shepherd, Binuraj Menon, Heidi Fisk, Anna Winona Struck, Colin Levy, David Leys, Jason Micklefield, "A structure-guided switch in the regioselectivity of a tryptophan halogenase", Chembiochem, 9, 821-824 (2016), DOI: 10.1002/cbic.201600051
- Joseph A Newman, Christopher Cooper, Annette Roos, Hazel Aitkenhead, Udo C. T. Oppermann, Hearn J. Cho, Roman Osman, Opher Gileadi, Hiroshi Shiku, "Structures of two melanoma-associated antigens suggest allosteric regulation of effector binding", Plos One, 11 (2016), DOI: 10.1371/journal.pone.0148762
- N. Cekic, J. E. Heinonen, K. A. Stubbs, C. Roth, Y. He, A. J. Bennet, E. J. Mc Eachern, G. J. Davies, D. J. Vocadlo, "Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase", Chemical Science (2016), DOI: 10.1039/C6SC00370B
- Lutz Vogeley, Toufic El Arnaout, Jonathan Bailey, Phillip J. Stansfeld, Coiiín Boland, Martin Caffrey, "Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin", Science, 351 (6275), 876 - 880 (2016), DOI: 10.1126/science.aad3747
- Diana Constantinescu- Aruxandei, Biljana Petrovic- Stojanovska, J. Carlos Penedo, Malcolm F. White, James Naismith, "Mechanism of DNA loading by the DNA repair helicase XPD", Nucleic Acids Research, 44, 2806–2815 (2016), DOI: 10.1093/nar/gkw102
- Yinghong Gu, Huanyu Li, Haohao Dong, Yi Zeng, Zhengyu Zhang, Neil G. Paterson, Phillip J. Stansfeld, Zhongshan Wang, Yizheng Zhang, Wenjian Wang, Changjiang Dong, "Structural basis of outer membrane protein insertion by the BAM complex", Nature, 531, 64 - 69 (2016), DOI: 10.1038/nature17199
- Anja Paatero, Katja Rosti, Alexander V. Shkumatov, Celeste Sele, Cecilia Brunello, Kai Kysenius, Prosanta Singha, Ville Jokinen, Henri Huttunen, Tommi Kajander, "Crystal structure of an engineered LRRTM2 synaptic adhesion molecule and a model for neurexin binding", Biochemistry, 55 (6), 914 - 926 (2016), DOI: 10.1021/acs.biochem.5b00971
- Giovanni Mattia Lazzerini, Giuseppe Maria Paternò, Giulia Tregnago, Neil Treat, Natalie Stingelin, Andrew Yacoot, Franco Cacialli, "Traceable atomic force microscopy of high-quality solvent-free crystals of [6,6]-phenyl-C61-butyric acid methyl ester", Applied Physics Letters, 108 (2016), DOI: 10.1063/1.4941227
- Colin Nave, Geoff Sutton, Gwyndaf Evans, Robin Owen, Christoph Rau, Ian Robinson, Dave Stuart, "Imperfection and radiation damage in protein crystals studied with coherent radiation", Journal Of Synchrotron Radiation, 23, 228 - 237 (2016), DOI: 10.1107/S1600577515019700
- Renate Gessmann, Hans Brückner, Kyriacos Petratos, "The crystal structure of Z-(Aib)10-OH at 0.65 Å resolution: three complete turns of 310-helix", Journal Of Peptide Science, 22 (2016), DOI: 10.1002/psc.2842
- Kristof Moonens, Pär Gideonsson, Suresh Subedi, Jeanna Bugaytsova, Ema Romaõ, Melissa Mendez, Jenny Nordén, Mahsa Fallah, Lena Rakhimova, Anna Shevtsova, Martina Lahmann, Gaetano Castaldo, Kristoffer Brännström, Fanny Coppens, Alvin W Lo, Tor Ny, Jay v Solnick, Guy Vandenbussche, Stefan Oscarson, Lennart Hammarström, Anna Arnqvist, Douglas e Berg, Serge Muyldermans, Thomas Borén, Han Remaut, "Structural insights into polymorphic abo glycan binding by Helicobacter pylori", Cell Host & Microbe, 19, 55 - 66 (2016), DOI: 10.1016/j.chom.2015.12.004
- [Thesis] Marcela Salazar Alvarez, "Targeted protein adsorption on the surface of biomaterials" (2016)
- Shutian Liang, Ravi Acharya, "Structural basis of substrate specificity in porcine RNase 4", Febs Journal (2016), DOI: 10.1111/febs.13646
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