Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I03 Contact
Beamline Phone Number:
+44 (0) 1235 778707
Acting Principal Beamline Scientist:
Dave Hall
Tel: +44 (0) 1235 778926
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I03 MX
Status: Operational
Beamsize: 90 µm x 20 µm
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
These publications are based on data gathered on beamline I03. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
168 items found for 2022 [total: 2353]
The identification of potent, selective, and brain penetrant PI5P4Kγ inhibitors as in vivo-ready tool molecules Journal Of Medicinal Chemistry, Dec 2022 DOI: 10.1021/acs.jmedchem.2c01693
A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75 Cell Reports, Dec 2022 DOI: 10.1016/j.celrep.2022.111903
The crystal structure of Bacillus thuringiensis Tpp80Aa1 and its interaction with galactose-containing glycolipids Toxins, 14 Dec 2022 DOI: 10.3390/toxins14120863
Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS Nature Communications, 13 Dec 2022 DOI: 10.1038/s41467-022-35340-z
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein Science Immunology, 7 Dec 2022 DOI: 10.1126/sciimmunol.ade5686
Journal Paper I03-Macromolecular Crystallography
Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation Nature Communications, 13 Dec 2022 DOI: 10.1038/s41467-022-34960-9
4-O-substituted glucuronic cyclophellitols are selective mechanism-based heparanase inhibitors Chemmedchem, Dec 2022 DOI: 10.1002/cmdc.202200580
Sourcing thermotolerant poly(ethylene terephthalate) hydrolase scaffolds from natural diversity Nature Communications, 13 Dec 2022 DOI: 10.1038/s41467-022-35237-x
Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity Nature Communications, 13 Dec 2022 DOI: 10.1038/s41467-022-35300-7
Crystal structure of the feruloyl esterase from Lentilactobacillus buchneri reveals a novel homodimeric state Frontiers In Microbiology, 13 Dec 2022 DOI: 10.3389/fmicb.2022.1050160
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure and function of the NS5 methyltransferase domain from Usutu virus Antiviral Research, 208 Dec 2022 DOI: 10.1016/j.antiviral.2022.105460
Journal Paper I03-Macromolecular Crystallography
Peptide transport in Bacillus subtilis – structure and specificity in the extracellular solute binding proteins OppA and DppE Microbiology, 168 Dec 2022 DOI: 10.1099/mic.0.001274
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries Proceedings Of The National Academy Of Sciences, 119 Dec 2022 DOI: 10.1073/pnas.2210435119
New research to understand disease resistance in crops Dec 2022
Science Highlight I03-Macromolecular Crystallography
Humoral responses against SARS-CoV-2 Omicron BA.2.11, BA.2.12.1 and BA.2.13 from vaccine and BA.1 serum Cell Discovery, 8 Nov 2022 DOI: 10.1038/s41421-022-00482-3
Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains Journal Of Biological Chemistry, 10 Nov 2022 DOI: 10.1016/j.jbc.2022.102750
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays Scientific Reports, 12 Nov 2022 DOI: 10.1038/s41598-022-23264-z
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Crystal structure of 4,6-α-glucanotransferase GtfC-Δc from thermophilic Geobacillus 12AMOR1: starch transglycosylation in non-permuted GH70 enzymes Journal Of Agricultural And Food Chemistry, Nov 2022 DOI: 10.1021/acs.jafc.2c06394
Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6 Cell Discovery, 8 Nov 2022 DOI: 10.1038/s41421-022-00493-0
Crystal structure of DNA polymerase I from Thermus phage G20c Acta Crystallographica Section D Structural Biology, 78 Nov 2022 DOI: 10.1107/S2059798322009895
Comparing the catalytic and structural characteristics of a 'short' unspecific peroxygenase (UPO) expressed in P. pastoris and E. coli Chembiochem, Nov 2022 DOI: 10.1002/cbic.202200558
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Synthesis of stereoenriched piperidines via chemo-enzymatic dearomatization of activated pyridines Journal Of The American Chemical Society, 119 Nov 2022 DOI: 10.1021/jacs.2c07143
Systems-wide dissection of organic acid assimilation in Pseudomonas aeruginosa reveals a novel path to underground metabolism Mbio, Nov 2022 DOI: 10.1128/mbio.02541-22
Structural characterization of Glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum Molecular And Biochemical Parasitology, 3 Nov 2022 DOI: 10.1016/j.molbiopara.2022.111530
Journal Paper I03-Macromolecular Crystallography
Biochemical and structural insights into FIH‐catalysed hydroxylation of transient receptor potential ankyrin repeat domains Chembiochem, Nov 2022 DOI: 10.1002/cbic.202200576
Structural insights into the contactin 1 - neurofascin 155 adhesion complex Nature Communications, 13 Nov 2022 DOI: 10.1038/s41467-022-34302-9
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Light activation of Orange Carotenoid Protein reveals bicycle-pedal single-bond isomerization Nature Communications, 13 Oct 2022 DOI: 10.1038/s41467-022-34137-4
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I23-Long wavelength MX open access
Exploring chemical space in covalent and competitive glycosidase inhibitor design Oct 2022
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Expansion of the catalytic repertoire of alcohol dehydrogenases in plant metabolism Angewandte Chemie International Edition, Oct 2022 DOI: 10.1002/anie.202210934
CYP153A71 from Alcanivorax dieselolei: oxidation beyond monoterminal hydroxylation of n-alkanes Catalysts, 12 Oct 2022 DOI: 10.3390/catal12101213
GPC3-Unc5 receptor complex structure and role in cell migration Cell, 185 Oct 2022 DOI: 10.1016/j.cell.2022.09.025
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Recombinant production and investigation of neurotransmitter channels and transporters Oct 2022
Thesis I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A blast fungus zinc-finger fold effector binds to a hydrophobic pocket in host Exo70 proteins to modulate immune recognition in rice Proceedings Of The National Academy Of Sciences, 119 Oct 2022 DOI: 10.1073/pnas.2210559119
Non-canonical Staphylococcus aureus pathogenicity island repression Nucleic Acids Research, 2 Oct 2022 DOI: 10.1093/nar/gkac855
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Discovery, characterization, and structure-based optimization of small-molecule in vitro and in vivo probes for human DNA polymerase theta Journal Of Medicinal Chemistry, 592 Oct 2022 DOI: 10.1021/acs.jmedchem.2c01142
Journal Paper I03-Macromolecular Crystallography
Glycosidases as an analytical tool in glycomics assays Oct 2022
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography VMXi-Versatile Macromolecular Crystallography in situ
Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: towards a model of the C-P4H α2β2 tetramer Journal Of Biological Chemistry, 22 Oct 2022 DOI: 10.1016/j.jbc.2022.102614
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography VMXi-Versatile Macromolecular Crystallography in situ open access
Bacterial divisome protein FtsA forms curved antiparallel double filaments when binding to FtsN Nature Microbiology, 10 Sept 2022 DOI: 10.1038/s41564-022-01206-9
Identification of histone peptide binding specificity and small-molecule ligands for the TRIM33α and TRIM33β bromodomains Acs Chemical Biology, Sept 2022 DOI: 10.1021/acschembio.2c00266
Structurally informed mutagenesis of a stereochemically promiscuous aldolase produces mutants that catalyze the diastereoselective syntheses of all four stereoisomers of 3-deoxy-hexulosonic acid Acs Catalysis, Sept 2022 DOI: 10.1021/acscatal.2c03285
A structural and biophysical dissection of bacterial sulfoquinovose catabolism Sept 2022
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies Nature Communications, 13 Sept 2022 DOI: 10.1038/s41467-022-33379-6
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural and functional characterisation of a stable, broad-specificity multimeric sialidase from the oral pathogen Tannerella forsythia Biochemical Journal, 479 Sept 2022 DOI: 10.1042/BCJ20220244
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Plant N-glycan breakdown by human gut Bacteroides Proceedings Of The National Academy Of Sciences, 119 Sept 2022 DOI: 10.1073/pnas.2208168119
Non-active site mutations in the HIV protease: Diminished drug binding affinity is achieved through modulating the hydrophobic sliding mechanism International Journal Of Biological Macromolecules, 217 Sept 2022 DOI: 10.1016/j.ijbiomac.2022.07.033
Journal Paper I03-Macromolecular Crystallography
Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1) Scientific Reports, 12 Sept 2022 DOI: 10.1038/s41598-022-18795-4
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography open access
Development and characterization of type I, type II, and type III LIM-kinase chemical probes Journal Of Medicinal Chemistry, 1550 Sept 2022 DOI: 10.1021/acs.jmedchem.2c01106
Journal Paper I03-Macromolecular Crystallography
Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip Communications Biology, 5 Sept 2022 DOI: 10.1038/s42003-022-03886-9
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Plant vernalization proteins contain unusual PHD superdomains without histone H3 binding activity Journal Of Biological Chemistry, 4 Sept 2022 DOI: 10.1016/j.jbc.2022.102540
Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen Nature Communications, 13 Sept 2022 DOI: 10.1038/s41467-022-32811-1
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The primary familial brain calcification-associated protein MYORG is an α-galactosidase with restricted substrate specificity Plos Biology, 20 Sept 2022 DOI: 10.1371/journal.pbio.3001764
Fluorescent proteins: crystallization, structural determination, and nonnatural amino acid incorporation Sept 2022 DOI: 10.1007/978-1-0716-2667-2_5
Book Chapter I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural insights into the mechanism of adaptive ribosomal modification by Pseudomonas RimK Proteins: Structure, Function, And Bioinformatics, Sept 2022 DOI: 10.1002/prot.26429
Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits Rsc Medicinal Chemistry, 33 Sept 2022 DOI: 10.1039/D2MD00163B
Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei Molecular Biology Of The Cell, Sept 2022 DOI: 10.1091/mbc.E22-07-0269-T
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A designed photoenzyme for enantioselective [2+2]-cycloadditions Nature, Sept 2022 DOI: 10.1038/s41586-022-05335-3
Journal Paper I03-Macromolecular Crystallography
Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo Proceedings Of The National Academy Of Sciences, 119 Aug 2022 DOI: 10.1073/pnas.2203167119
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics The Febs Journal, Aug 2022 DOI: 10.1111/febs.16603
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse Nature Communications, 13 Aug 2022 DOI: 10.1038/s41467-022-32577-6
Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance Nature Communications, 13 Aug 2022 DOI: 10.1038/s41467-022-32630-4
Discovery of a selective c-MET inhibitor with a novel binding mode Bioorganic & Medicinal Chemistry Letters, 12 Aug 2022 DOI: 10.1016/j.bmcl.2022.128948
Structural basis of DNA packaging by a ring-type ATPase from an archetypal viral system Nucleic Acids Research, 50 Aug 2022 DOI: 10.1093/nar/gkac647
Uncovering lipopolysaccharide regulation in bacteria via the critical lipid binding tunnel of YciS/YciM Iscience, Aug 2022 DOI: 10.1016/j.isci.2022.104988
Toolkit of approaches to support target-focused drug discovery for Plasmodium falciparum lysyl tRNA synthetase Acs Infectious Diseases, Aug 2022 DOI: 10.1021/acsinfecdis.2c00364
H2S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine Cellular And Molecular Life Sciences, 79 Aug 2022 DOI: 10.1007/s00018-022-04479-9
PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery Rsc Medicinal Chemistry, 15 Aug 2022 DOI: 10.1039/D2MD00197G
Phosphoglucose isomerase is important for Aspergillus fumigatuscell wall biogenesis Mbio, 228 Aug 2022 DOI: 10.1128/mbio.01426-22
Directed evolution of an efficient and thermostable PET depolymerase Nature Catalysis, 3 Aug 2022 DOI: 10.1038/s41929-022-00821-3
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors Nature Communications, 13 Aug 2022 DOI: 10.1038/s41467-022-32436-4
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Expanding the substrate scope of Native Amine Dehydrogenases through in silico structural exploration and targeted protein engineering Chemcatchem, Aug 2022 DOI: 10.1002/cctc.202200880
Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15 European Journal Of Medicinal Chemistry, 237 Jul 2022 DOI: 10.1016/j.ejmech.2022.114362
Journal Paper I03-Macromolecular Crystallography
Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility Science Immunology, 7 Jul 2022 DOI: 10.1126/sciimmunol.abm3723
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes Proceedings Of The National Academy Of Sciences, 119 Jul 2022 DOI: 10.1073/pnas.2205412119
Journal Paper I03-Macromolecular Crystallography Krios II-Titan Krios II at Diamond Krios IV-Titan Krios IV at Diamond open access
Functional metagenomic screening identifies an unexpected β-glucuronidase Nature Chemical Biology, 48 Jul 2022 DOI: 10.1038/s41589-022-01071-x
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I23-Long wavelength MX
Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase Journal Of Biological Chemistry, 35 Jul 2022 DOI: 10.1016/j.jbc.2022.102249
Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae Plos Pathogens, 18 Jul 2022 DOI: 10.1371/journal.ppat.1010334
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy Journal For Immunotherapy Of Cancer, 10 Jul 2022 DOI: 10.1136/jitc-2022-004600
Evolution of homo‐oligomerization of methionine S‐adenosyltransferases is replete with structure–function constrains Protein Science, 31 Jul 2022 DOI: 10.1002/pro.4352
Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues Current Research In Structural Biology, D66 Jul 2022 DOI: 10.1016/j.crstbi.2022.07.001
Hijacking of the enterobactin pathway by a synthetic catechol vector designed for oxazolidinone antibiotic delivery in Pseudomonas aeruginosa Acs Infectious Diseases, Jul 2022 DOI: 10.1021/acsinfecdis.2c00202
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition Proceedings Of The National Academy Of Sciences, 119 Jul 2022 DOI: 10.1073/pnas.2200260119
Optimization of hERG and pharmacokinetic properties for basic dihydro-8H-purin-8-one inhibitors of DNA-PK Acs Medicinal Chemistry Letters, Jul 2022 DOI: 10.1021/acsmedchemlett.2c00172
Journal Paper I03-Macromolecular Crystallography
Crystal structures of WrbA, a spurious target of the salicylidene acylhydrazide inhibitors of type III secretion in Gram-negative pathogens, and verification of improved specificity of next-generation compounds Microbiology, 168 Jul 2022 DOI: 10.1099/mic.0.001211
Journal Paper I03-Macromolecular Crystallography
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides Nature Communications, 13 Jul 2022 DOI: 10.1038/s41467-022-31636-2
Discovery of an oral, rule of 5 compliant, interleukin 17A protein–protein interaction modulator for the potential treatment of psoriasis and other inflammatory diseases Journal Of Medicinal Chemistry, 65 Jul 2022 DOI: 10.1021/acs.jmedchem.2c00422
A single sensor controls large variations in zinc quotas in a marine cyanobacterium Nature Chemical Biology, 5 June 2022 DOI: 10.1038/s41589-022-01051-1
Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes Cell Reports, 39 June 2022 DOI: 10.1016/j.celrep.2022.110959
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Crystal structure of Trypanosoma cruzi heme peroxidase and characterisation of its substrate specificity and compound I intermediate Journal Of Biological Chemistry, June 2022 DOI: 10.1016/j.jbc.2022.102204
Structural and functional studies of cannabidiol interactions with voltage-gated sodium channels June 2022
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Multitarget, selective compound design yields potent inhibitors of a kinetoplastid pteridine reductase 1 Journal Of Medicinal Chemistry, 51 June 2022 DOI: 10.1021/acs.jmedchem.2c00232
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
The 3D ‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism Febs Letters, June 2022 DOI: 10.1002/1873-3468.14413
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Optimizing shape complementarity enables the discovery of potent tricyclic BCL6 inhibitors Journal Of Medicinal Chemistry, June 2022 DOI: 10.1021/acs.jmedchem.1c02174
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Improved binding affinity and pharmacokinetics enable sustained degradation of BCL6 in vivo Journal Of Medicinal Chemistry, June 2022 DOI: 10.1021/acs.jmedchem.1c02175
Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota Nature Chemical Biology, 19 June 2022 DOI: 10.1038/s41589-022-01039-x
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum Cell, June 2022 DOI: 10.1016/j.cell.2022.06.005
Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery Nature Communications, 13 June 2022 DOI: 10.1038/s41467-022-30656-2
Structural basis for the inhibition of human angiotensin‐1 converting enzyme by fosinoprilat The Febs Journal, June 2022 DOI: 10.1111/febs.16543
High-affinity anti-Arc nanobodies provide tools for structural and functional studies Plos One, 17 June 2022 DOI: 10.1371/journal.pone.0269281
Insights to the structural basis for the stereospecificity of the Escherichia coli phytase, AppA International Journal Of Molecular Sciences, 23 June 2022 DOI: 10.3390/ijms23116346
A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193 Structure, 369 June 2022 DOI: 10.1016/j.str.2022.05.009
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
De novo design of discrete, stable 310-helix peptide assemblies Nature, 37 June 2022 DOI: 10.1038/s41586-022-04868-x
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural characterization of l-galactose dehydrogenase: an essential enzyme for vitamin C biosynthesis Plant And Cell Physiology, June 2022 DOI: 10.1093/pcp/pcac090
The structure of Phocaeicola vulgatus sialic acid acetylesterase Acta Crystallographica Section D Structural Biology, 78 May 2022 DOI: 10.1107/S2059798322003357
Discovery, characterization, and metabolic engineering of Rieske non-heme iron monooxygenases for guaiacol O-demethylation Chem Catalysis, 55 May 2022 DOI: 10.1016/j.checat.2022.04.019
Journal Paper I03-Macromolecular Crystallography
Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors Proceedings Of The National Academy Of Sciences, 119 May 2022 DOI: 10.1073/pnas.2117310119
Potent cross-reactive antibodies following Omicron breakthrough in vaccinees Cell, May 2022 DOI: 10.1016/j.cell.2022.05.014
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access
Production and crystallization of nanobodies in complex with the receptor binding domain of the SARS-COV-2 spike protein Bio-Protocol, 12 May 2022 DOI: 10.21769/BioProtoc.4406
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Molecular basis for the initiation of DNA primer synthesis Nature, 43 May 2022 DOI: 10.1038/s41586-022-04695-0
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Penicillin derivatives inhibit the SARS-COV-2 main protease by reaction with its nucleophilic cysteine Journal Of Medicinal Chemistry, 49 May 2022 DOI: 10.1021/acs.jmedchem.1c02214
Penicillanic acid sulfones inactivate the extended-spectrum β-lactamase CTX-M-15 through formation of a serine-lysine cross-link: an alternative mechanism of β-lactamase inhibition Mbio, May 2022 DOI: 10.1128/mbio.01793-21
O-Fucosylation stabilizes the TSR3 motif in Thrombospondin-1 by interacting with nearby amino acids and protecting a disulfide bond Journal Of Biological Chemistry, 36 May 2022 DOI: 10.1016/j.jbc.2022.102047
Phenyl Bis-sulfonamide Keap1-Nrf2 protein–protein interaction inhibitors with an alternative binding mode Journal Of Medicinal Chemistry, May 2022 DOI: 10.1021/acs.jmedchem.2c00457
Ruminococcus gnavus GH98 substrate specificity to blood group A antigen contributes to mucin glycan foraging Access Microbiology, 4 May 2022 DOI: 10.1099/acmi.ac2021.po0311
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography VMXi-Versatile Macromolecular Crystallography in situ open access
Structural basis for long-chain isoprenoid synthesis by cis-prenyltransferases Science Advances, 8 May 2022 DOI: 10.1126/sciadv.abn1171
Structural characterization of Mycobacterium abscessus phosphopantetheine adenylyl transferase ligand interactions: implications for fragment-based drug design Frontiers In Molecular Biosciences, 9 May 2022 DOI: 10.3389/fmolb.2022.880432
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans Scientific Reports, 12 Apr 2022 DOI: 10.1038/s41598-022-10028-y
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural validation and assessment of AlphaFold2 predictions for centrosomal and centriolar proteins and their complexes Communications Biology, 5 Apr 2022 DOI: 10.1038/s42003-022-03269-0
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
FCHO controls AP2’s initiating role in endocytosis through a PtdIns(4,5)P2-dependent switch Science Advances, 8 Apr 2022 DOI: 10.1126/sciadv.abn2018
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
CPR-C4 is a highly conserved novel protease from the Candidate Phyla Radiation with remote structural homology to human vasohibins Journal Of Biological Chemistry, 172 Apr 2022 DOI: 10.1016/j.jbc.2022.101919
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Spinning sugars in antigen biosynthesis: characterization of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases Journal Of Biological Chemistry, 11 Apr 2022 DOI: 10.1016/j.jbc.2022.101903
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase Communications Biology, 5 Apr 2022 DOI: 10.1038/s42003-022-03264-5
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development Structure, 66 Apr 2022 DOI: 10.1016/j.str.2022.03.017
Journal Paper I03-Macromolecular Crystallography
Multifunctional biocatalyst for conjugate reduction and reductive amination Nature, 604 Apr 2022 DOI: 10.1038/s41586-022-04458-x
Journal Paper I03-Macromolecular Crystallography
Expression, purification and crystallization of a novel metagenome-derived salicylaldehyde dehydrogenase from Alpine soil Acta Crystallographica Section F Structural Biology Communications, 78 Apr 2022 DOI: 10.1107/S2053230X22002345
The structures of the C146A variant of the amidase from Pyrococcus horikoshii bound to glutaramide and acetamide suggest the basis of amide recognition Journal Of Structural Biology, 60 Apr 2022 DOI: 10.1016/j.jsb.2022.107859
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Crystal structure of levansucrase from the gram-negative bacterium Brenneria provides insights into its product size specificity Journal Of Agricultural And Food Chemistry, 30 Apr 2022 DOI: 10.1021/acs.jafc.2c01225
Journal Paper I03-Macromolecular Crystallography
The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity Nature Communications, 13 Apr 2022 DOI: 10.1038/s41467-022-29286-5
Development of small cyclic peptides targeting the CK2α/β interface Chemical Communications, 58 Apr 2022 DOI: 10.1039/D2CC00707J
Mechanisms of substrate recognition and N 6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes Nucleic Acids Research, 28 Mar 2022 DOI: 10.1093/nar/gkac195
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Ruthenium polypyridyl complex bound to a unimolecular chair-form G-quadruplex Journal Of The American Chemical Society, 75 Mar 2022 DOI: 10.1021/jacs.2c00178
Hierarchical self-assembly of a supramolecular protein-metal cage encapsulating a polyoxometalate guest Crystal Growth & Design, 22 Mar 2022 DOI: 10.1021/acs.cgd.1c01138
Journal Paper I03-Macromolecular Crystallography
Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor Annals Of The Rheumatic Diseases, 81 Mar 2022 DOI: 10.1136/annrheumdis-2021-220500
Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel Structure, 41 Mar 2022 DOI: 10.1016/j.str.2022.02.005
The sulfoquinovosyl glycerol binding protein SmoF binds and accommodates plant sulfolipids Current Research In Structural Biology, 4 Mar 2022 DOI: 10.1016/j.crstbi.2022.03.001
Structure and mutation of the native amine dehydrogenase MATOUAmDH2 Chembiochem, Mar 2022 DOI: 10.1002/cbic.202200136
Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development Plos Pathogens, 18 Mar 2022 DOI: 10.1371/journal.ppat.1010363
Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity Communications Biology, 5 Mar 2022 DOI: 10.1038/s42003-022-03183-5
Biochemical and structural characterization of an aromatic ring–hydroxylating dioxygenase for terephthalic acid catabolism Proceedings Of The National Academy Of Sciences, 119 Mar 2022 DOI: 10.1073/pnas.2121426119
Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1 Communications Biology, 5 Mar 2022 DOI: 10.1038/s42003-022-03186-2
The zinc-binding motif in tankyrases is required for the structural integrity of the catalytic ADP-ribosyltransferase domain Open Biology, 12 Mar 2022 DOI: 10.1098/rsob.210365
Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase European Journal Of Medicinal Chemistry, 41 Mar 2022 DOI: 10.1016/j.ejmech.2022.114270
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Contrasting modes of new world arenavirus neutralization by immunization-elicited monoclonal antibodies Mbio, Mar 2022 DOI: 10.1128/mbio.02650-21
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase Biochemical Journal, 479 Mar 2022 DOI: 10.1042/BCJ20220019
Stabilization of the RAS:PDE6D complex is a novel strategy to inhibit RAS signaling Journal Of Medicinal Chemistry, 12 Feb 2022 DOI: 10.1021/acs.jmedchem.1c01265
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Heterotypic interactions drive antibody synergy against a malaria vaccine candidate Nature Communications, 13 Feb 2022 DOI: 10.1038/s41467-022-28601-4
Probing the requirements for dual angiotensin-converting enzyme c-domain selective/neprilysin inhibition Journal Of Medicinal Chemistry, 297 Feb 2022 DOI: 10.1021/acs.jmedchem.1c01924
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation Science Advances, Feb 2022 DOI: 10.1126/sciadv.abm1759
Structure of a cereal purple acid phytase provides new insights to phytate degradation in plants Plant Communications, Feb 2022 DOI: 10.1016/j.xplc.2022.100305
An enzyme with high catalytic proficiency utilizes distal site substrate binding energy to stabilize the closed state but at the expense of substrate inhibition Acs Catalysis, Feb 2022 DOI: 10.1021/acscatal.1c05524
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Development of selective phosphatidylinositol 5-phosphate 4-kinase γ inhibitors with a non-ATP-competitive, allosteric binding mode Journal Of Medicinal Chemistry, 52 Feb 2022 DOI: 10.1021/acs.jmedchem.1c01819
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress Nature Cancer, 3 Feb 2022 DOI: 10.1038/s43018-022-00331-y
PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders Cellular And Molecular Life Sciences, 79 Feb 2022 DOI: 10.1007/s00018-022-04173-w
Expanding the repertoire of low-molecular-weight pentafluorosulfanyl-substituted scaffolds Chemmedchem, 59 Feb 2022 DOI: 10.1002/cmdc.202100641
VEGFA, B, C: implications of the C-terminal sequence variations for the interaction with neuropilins Biomolecules, 12 Feb 2022 DOI: 10.3390/biom12030372
Structure‐guided stabilization of pathogen‐derived peptide‐HLA‐E complexes using non‐natural amino acids conserves native TCR recognition European Journal Of Immunology, Feb 2022 DOI: 10.1002/eji.202149745
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses Cell, Jan 2022 DOI: 10.1016/j.cell.2021.12.046
Antibodies to cartilage oligomeric matrix protein are pathogenic in mice and may be clinically relevant in rheumatoid arthritis Arthritis & Rheumatology, Jan 2022 DOI: 10.1002/art.42072
Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies Nature Communications, 13 Jan 2022 DOI: 10.1038/s41467-021-27950-w
Debottlenecking 4-hydroxybenzoate hydroxylation in Pseudomonas putida KT2440 improves muconate productivity from p-coumarate Metabolic Engineering, 34 Jan 2022 DOI: 10.1016/j.ymben.2021.12.010
Journal Paper I03-Macromolecular Crystallography
Fragment-based exploration of the 14-3-3/Amot-p130 interface Current Research In Structural Biology, 4 Jan 2022 DOI: 10.1016/j.crstbi.2021.12.003
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) European Journal Of Medicinal Chemistry, 393 Jan 2022 DOI: 10.1016/j.ejmech.2022.114105
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Tropocollagen springs allow collagen fibrils to stretch elastically Acta Biomaterialia, 8 Jan 2022 DOI: 10.1016/j.actbio.2022.01.041
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I22-Small angle scattering & Diffraction open access
Development of inhibitors of SAICAR synthetase (PurC) from Mycobacterium abscessus using a fragment-based approach Acs Infectious Diseases, Jan 2022 DOI: 10.1021/acsinfecdis.1c00432
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Exploring divalent conjugates of 5-N-acetyl-neuraminic acid as inhibitors of coxsackievirus A24 variant (CVA24v) transduction Rsc Advances, 12 Jan 2022 DOI: 10.1039/D1RA08968D
Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications Journal Of The American Chemical Society, Jan 2022 DOI: 10.1021/jacs.1c10504
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Discovery of novel inhibitors of uridine diphosphate-n-acetylenolpyruvylglucosamine reductase (MurB) from Pseudomonas aeruginosa, an opportunistic infectious agent causing death in cystic fibrosis patients Journal Of Medicinal Chemistry, 48 Jan 2022 DOI: 10.1021/acs.jmedchem.1c01684
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Virtual screening directly identifies new fragment-sized inhibitors of carboxylesterase notum with nanomolar activity Journal Of Medicinal Chemistry, 65 Jan 2022 DOI: 10.1021/acs.jmedchem.1c01735
Journal Paper I03-Macromolecular Crystallography
Structural analysis of the cattle antibody repertoire Jan 2022
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography VMXi-Versatile Macromolecular Crystallography in situ
- Timothy P. C. Rooney, Gregory G. Aldred, Helen K. Boffey, Henriëtte M. G. Willems, Simon Edwards, Stephen J. Chawner, Duncan E. Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews, "The identification of potent, selective, and brain penetrant PI5P4Kγ inhibitors as in vivo-ready tool molecules", Journal Of Medicinal Chemistry (2022), DOI: 10.1021/acs.jmedchem.2c01693
- Jiandong Huo, Aiste Dijokaite-Guraliuc, Chang Liu, Raksha Das, Piyada Supasa, Muneeswaran Selvaraj, Rungtiwa Nutalai, Daming Zhou, Alexander J. Mentzer, Donal Skelly, Thomas G. Ritter, Ali Amini, Sagida Bibi, Sandra Adele, Sile Ann Johnson, Neil G. Paterson, Mark A. Williams, David R. Hall, Megan Plowright, Thomas A. H. Newman, Hailey Hornsby, Thushan I. De Silva, Nigel Temperton, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Andrew J. Pollard, Teresa Lambe, Philip Goulder, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton, "A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75", Cell Reports (2022), DOI: 10.1016/j.celrep.2022.111903
- Hannah L. Best, Lainey J. Williamson, Magdalena Lipka-Lloyd, Helen Waller-Evans, Emyr Lloyd-Evans, Pierre J. Rizkallah, Colin Berry, "The crystal structure of Bacillus thuringiensis Tpp80Aa1 and its interaction with galactose-containing glycolipids", Toxins, 14 (2022), DOI: 10.3390/toxins14120863
- Abigail S. L. Sudol, John Butler, Dylan P. Ivory, Ivo Tews, Max Crispin, "Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-35340-z
- Silvia Gaggero, Jonathan Martinez-Fabregas, Adeline Cozzani, Paul K. Fyfe, Malo Leprohon, Jie Yang, F. Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G. Conti, Stephan Wilmes, Elizabeth Pohler, Manuel Van Gijsel Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lindorff-Larsen, Rahul Roychoudhuri, Ignacio Moraga, Suman Mitra, "IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein", Science Immunology, 7 (2022), DOI: 10.1126/sciimmunol.ade5686
- Gemma Fisher, Marina Corbella, Magnus S. Alphey, John Nicholson, Benjamin J. Read, Shina C. L. Kamerlin, Rafael G. Da Silva, "Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-34960-9
- Valentina Borlandelli, Zachary Armstrong, Alba Nin-Hill, Jeroen Codée, Lluís Raich, Marta Artola, Carme Rovira, Gideon Davies, Hermen S. Overkleeft, "4-O-substituted glucuronic cyclophellitols are selective mechanism-based heparanase inhibitors", Chemmedchem (2022), DOI: 10.1002/cmdc.202200580
- Erika Erickson, Japheth E. Gado, Luisana Avilán, Felicia Bratti, Richard K. Brizendine, Paul A. Cox, Raj Gill, Rosie Graham, Dong-Jin Kim, Gerhard König, William E. Michener, Saroj Poudel, Kelsey J. Ramirez, Thomas J. Shakespeare, Michael Zahn, Eric S. Boyd, Christina M. Payne, Jennifer L. Dubois, Andrew R. Pickford, Gregg T. Beckham, John E. Mcgeehan, "Sourcing thermotolerant poly(ethylene terephthalate) hydrolase scaffolds from natural diversity", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-35237-x
- Diego Esposito, Jane Dudley-Fraser, Acely Garza-Garcia, Katrin Rittinger, "Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-35300-7
- Kamyar Mogodiniyai Kasmaei, Dayanand C. Kalyani, Tom Reichenbach, Amparo Jiménez-Quero, Francisco Vilaplana, Christina Divne, "Crystal structure of the feruloyl esterase from Lentilactobacillus buchneri reveals a novel homodimeric state", Frontiers In Microbiology, 13 (2022), DOI: 10.3389/fmicb.2022.1050160
- Diego S. Ferrero, Laura Albentosa-González, Antonio Mas, Nuria Verdaguer, "Structure and function of the NS5 methyltransferase domain from Usutu virus", Antiviral Research, 208 (2022), DOI: 10.1016/j.antiviral.2022.105460
- Adam M. Hughes, John F. Darby, Eleanor J. Dodson, Samuel J. Wilson, Johan P. Turkenburg, Gavin H. Thomas, Anthony J. Wilkinson, "Peptide transport in Bacillus subtilis – structure and specificity in the extracellular solute binding proteins OppA and DppE", Microbiology, 168 (2022), DOI: 10.1099/mic.0.001274
- Kunhua Li, Olena S. Tokareva, Ty M. Thomson, Sebastian C. T. Wahl, Tara L. Travaline, Jessica D. Ramirez, Santosh K. Choudary, Sorabh Agarwal, Ward G. Walkup, Tivoli J. Olsen, Matthew J. Brennan, Gregory L. Verdine, John H. Mcgee, "De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries", Proceedings Of The National Academy Of Sciences, 119 (2022), DOI: 10.1073/pnas.2210435119
- [Science Highlight] Diamond Light Source, "New research to understand disease resistance in crops" (2022)
- Jiandong Huo, Aiste Dijokaite-Guraliuc, Rungtiwa Nutalai, Raksha Das, Daming Zhou, Alexander J. Mentzer, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton, "Humoral responses against SARS-CoV-2 Omicron BA.2.11, BA.2.12.1 and BA.2.13 from vaccine and BA.1 serum", Cell Discovery, 8 (2022), DOI: 10.1038/s41421-022-00482-3
- Iain Hay, Maria Shamin, Eve R. Caroe, Ahmed S. A. Mohamed, Dmitri I. Svergun, Cy M. Jeffries, Stephen C. Graham, Hayley J. Sharpe, Janet E. Deane, "Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains", Journal Of Biological Chemistry, 10 (2022), DOI: 10.1016/j.jbc.2022.102750
- Olivier A. Pierrat, Manjuan Liu, Gavin W. Collie, Kartika N. Shetty, Matthew J. Rodrigues, Yann-Vai Le Bihan, Emma A. Gunnell, P. Craig Mcandrew, Mark Stubbs, Martin G. Rowlands, Norhakim Yahya, Erald Shehu, Rachel Talbot, Lisa Pickard, Benjamin R. Bellenie, Kwai-Ming J. Cheung, Ludovic Drouin, Paolo Innocenti, Hannah Woodward, Owen A. Davis, Matthew G. Lloyd, Ana Varela, Rosemary Huckvale, Fabio Broccatelli, Michael Carter, David Galiwango, Angela Hayes, Florence I. Raynaud, Christopher Bryant, Steven Whittaker, Olivia W. Rossanese, Swen Hoelder, Rosemary Burke, Rob L. M. Van Montfort, "Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays", Scientific Reports, 12 (2022), DOI: 10.1038/s41598-022-23264-z
- Tjaard Pijning, Evelien M. Te Poele, Tijn C. De Leeuw, Albert Guskov, Lubbert Dijkhuizen, "Crystal structure of 4,6-α-glucanotransferase GtfC-Δc from thermophilic Geobacillus 12AMOR1: starch transglycosylation in non-permuted GH70 enzymes", Journal Of Agricultural And Food Chemistry (2022), DOI: 10.1021/acs.jafc.2c06394
- Aiste Dijokaite-Guraliuc, Raksha Das, Rungtiwa Nutalai, Daming Zhou, Alexander J. Mentzer, Chang Liu, Piyada Supasa, Susanna J. Dunachie, Teresa Lambe, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, Jiandong Huo, David I. Stuart, Gavin R. Screaton, "Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6", Cell Discovery, 8 (2022), DOI: 10.1038/s41421-022-00493-0
- Josefin Ahlqvist, Javier A. Linares-Pastén, Andrius Jasilionis, Martin Welin, Maria Håkansson, L. Anders Svensson, Lei Wang, Hildegard Watzlawick, Arnþór Ævarsson, Ólafur H. Friðjónsson, Guðmundur Ó. Hreggviðsson, Bernd Ketelsen Striberny, Eirin Glomsaker, Olav Lanes, Salam Al-Karadaghi, Eva Nordberg Karlsson, "Crystal structure of DNA polymerase I from Thermus phage G20c", Acta Crystallographica Section D Structural Biology, 78 (2022), DOI: 10.1107/S2059798322009895
- Wendy Robinson, Tamara Mielke, Benjamin Melling, Anibal Cuetos, Alison Parkin, William Unsworth, Jared Cartwright, Gideon Grogan, "Comparing the catalytic and structural characteristics of a 'short' unspecific peroxygenase (UPO) expressed in P. pastoris and E. coli", Chembiochem (2022), DOI: 10.1002/cbic.202200558
- Vanessa Harawa, Thomas W. Thorpe, James R. Marshall, Jack J. Sangster, Amelia K. Gilio, Lucian Pirvu, Rachel S. Heath, Antonio Angelastro, James D. Finnigan, Simon J. Charnock, Jordan W. Nafie, Gideon Grogan, Roger C. Whitehead, Nicholas J. Turner, "Synthesis of stereoenriched piperidines via chemo-enzymatic dearomatization of activated pyridines", Journal Of The American Chemical Society, 119 (2022), DOI: 10.1021/jacs.2c07143
- Stephen K. Dolan, Andre Wijaya, Michael Kohlstedt, Lars Gläser, Paul Brear, Rafael Silva-Rocha, Christoph Wittmann, Martin Welch, "Systems-wide dissection of organic acid assimilation in Pseudomonas aeruginosa reveals a novel path to underground metabolism", Mbio (2022), DOI: 10.1128/mbio.02541-22
- Vivek Kumar Sharma, Jyoti Chhibber-Goel, Manickam Yogavel, Amit Sharma, "Structural characterization of Glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum", Molecular And Biochemical Parasitology, 3 (2022), DOI: 10.1016/j.molbiopara.2022.111530
- Benjamin Saward, Thomas Leissing, Ian Clifton, Anthony Tumber, Christopher Timperley, Richard Hopkinson, Christopher J. Schofield, "Biochemical and structural insights into FIH‐catalysed hydroxylation of transient receptor potential ankyrin repeat domains", Chembiochem (2022), DOI: 10.1002/cbic.202200576
- Lucas M. P. Chataigner, Christos Gogou, Maurits A. Den Boer, Cátia P. Frias, Dominique M. E. Thies-Weesie, Joke C. M. Granneman, Albert J. R. Heck, Dimphna H. Meijer, Bert J. C. Janssen, "Structural insights into the contactin 1 - neurofascin 155 adhesion complex", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-34302-9
- Volha U. Chukhutsina, James M. Baxter, Alisia Fadini, Rhodri M. Morgan, Matthew A. Pope, Karim Maghlaoui, Christian M. Orr, Armin Wagner, Jasper J. Van Thor, "Light activation of Orange Carotenoid Protein reveals bicycle-pedal single-bond isomerization", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-34137-4
- [Thesis] Y. Chen, "Exploring chemical space in covalent and competitive glycosidase inhibitor design" (2022)
- Chloe Langley, Evangelos Tatsis, Benke Hong, Yoko Nakamura, Christian Paetz, Clare E. M. Stevenson, Jerome Basquin, David M. Lawson, Lorenzo Caputi, Sarah E. O'Connor, "Expansion of the catalytic repertoire of alcohol dehydrogenases in plant metabolism", Angewandte Chemie International Edition (2022), DOI: 10.1002/anie.202210934
- Cheri Louise Jacobs, Rodolpho Do Aido-Machado, Carmien Tolmie, Martha Sophia Smit, Diederik Johannes Opperman, "CYP153A71 from Alcanivorax dieselolei: oxidation beyond monoterminal hydroxylation of n-alkanes", Catalysts, 12 (2022), DOI: 10.3390/catal12101213
- Onno Akkermans, Céline Delloye-Bourgeois, Claudia Peregrina, Maria Carrasquero-Ordaz, Maria Kokolaki, Miguel Berbeira-Santana, Matthieu Chavent, Florie Reynaud, Ritu Raj, Jon Agirre, Metin Aksu, Eleanor S. White, Edward Lowe, Dounia Ben Amar, Sofia Zaballa, Jiandong Huo, Irene Pakos, Patrick T. N. Mccubbin, Davide Comoletti, Raymond J. Owens, Carol V. Robinson, Valérie Castellani, Daniel Del Toro, Elena Seiradake, "GPC3-Unc5 receptor complex structure and role in cell migration", Cell, 185, 3931 - 3949.e26 (2022), DOI: 10.1016/j.cell.2022.09.025
- [Thesis] Samuel Davis, "Recombinant production and investigation of neurotransmitter channels and transporters" (2022)
- Juan Carlos De La Concepcion, Koki Fujisaki, Adam R. Bentham, Neftaly Cruz Mireles, Victor Sanchez De Medina Hernandez, Motoki Shimizu, David M. Lawson, Sophien Kamoun, Ryohei Terauchi, Mark J. Banfield, "A blast fungus zinc-finger fold effector binds to a hydrophobic pocket in host Exo70 proteins to modulate immune recognition in rice", Proceedings Of The National Academy Of Sciences, 119 (2022), DOI: 10.1073/pnas.2210559119
- Laura Miguel-Romero, Mohammed Alqasmi, Julio Bacarizo, Jason A. Tan, Richard J. Cogdell, John Chen, Olwyn Byron, Gail E. Christie, Alberto Marina, José R. Penadés, "Non-canonical Staphylococcus aureus pathogenicity island repression", Nucleic Acids Research, 2 (2022), DOI: 10.1093/nar/gkac855
- Martin L. Stockley, Amanda Ferdinand, Giovanni Benedetti, Peter Blencowe, Susan M. Boyd, Mat Calder, Mark D. Charles, Lucy V. Edwardes, Tennyson Ekwuru, Harry Finch, Alessandro Galbiati, Lerin Geo, Diego Grande, Vera Grinkevich, Nicholas D. Holliday, Wojciech W. Krajewski, Ellen Macdonald, Jayesh B. Majithiya, Hollie Mccarron, Claire L. Mcwhirter, Viral Patel, Chris Pedder, Eeson Rajendra, Marco Ranzani, Laurent J. M. Rigoreau, Helen M. R. Robinson, Theresia Schaedler, Julija Sirina, Graeme C. M. Smith, Martin E. Swarbrick, Andrew P. Turnbull, Simon Willis, Robert A. Heald, "Discovery, characterization, and structure-based optimization of small-molecule in vitro and in vivo probes for human DNA polymerase theta", Journal Of Medicinal Chemistry, 592 (2022), DOI: 10.1021/acs.jmedchem.2c01142
- [Thesis] Osmond D. Rebello, "Glycosidases as an analytical tool in glycomics assays" (2022)
- Abhinandan V. Murthy, Ramita Sulu, Andrey Lebedev, Antti M. Salo, Kati Korhonen, Rajaram Venkatesan, Hongmin Tu, Ulrich Bergmann, Janne Jänis, Mikko Laitaoja, Lloyd Ruddock, Johanna Myllyharju, M. Kristian Koski, Rik. K. Wierenga, "Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: towards a model of the C-P4H α2β2 tetramer", Journal Of Biological Chemistry, 22 (2022), DOI: 10.1016/j.jbc.2022.102614
- Tim Nierhaus, Stephen H. Mclaughlin, Frank Bürmann, Danguole Kureisaite-Ciziene, Sarah L. Maslen, J. Mark Skehel, Conny W. H. Yu, Stefan M. V. Freund, Louise F. H. Funke, Jason W. Chin, Jan Lowe, "Bacterial divisome protein FtsA forms curved antiparallel double filaments when binding to FtsN", Nature Microbiology, 10 (2022), DOI: 10.1038/s41564-022-01206-9
- Angelina R. Sekirnik, Jessica K. Reynolds, Larissa See, Joseph P. Bluck, Amy R. Scorah, Cynthia Tallant, Bernadette Lee, Katarzyna B. Leszczynska, Rachel L. Grimley, R. Ian Storer, Marta Malattia, Sara Crespillo, Sofia Caria, Stephanie Duclos, Ester M. Hammond, Stefan Knapp, Garrett M. Morris, Fernanda Duarte, Philip C. Biggin, Stuart J. Conway, "Identification of histone peptide binding specificity and small-molecule ligands for the TRIM33α and TRIM33β bromodomains", Acs Chemical Biology (2022), DOI: 10.1021/acschembio.2c00266
- Sylvain F. Royer, Xuan Gao, Robin R. Groleau, Marc W. Van Der Kamp, Steven D. Bull, Michael J. Danson, Susan J. Crennell, "Structurally informed mutagenesis of a stereochemically promiscuous aldolase produces mutants that catalyze the diastereoselective syntheses of all four stereoisomers of 3-deoxy-hexulosonic acid", Acs Catalysis (2022), DOI: 10.1021/acscatal.2c03285
- [Thesis] Alexander Snow, "A structural and biophysical dissection of bacterial sulfoquinovose catabolism" (2022)
- Kuang-Ting Ko, Frank Lennartz, David Mekhaiel, Bora Guloglu, Arianna Marini, Danielle J. Deuker, Carole A. Long, Matthijs Jore, Kazutoyo Miura, Sumi Biswas, Matthew K. Higgins, "Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-33379-6
- Marianne J. Satur, Paulina A. Urbanowicz, Daniel I. R. Spencer, John Rafferty, Graham P. Stafford, "Structural and functional characterisation of a stable, broad-specificity multimeric sialidase from the oral pathogen Tannerella forsythia", Biochemical Journal, 479, 1785 - 1806 (2022), DOI: 10.1042/BCJ20220244
- Lucy I. Crouch, Paulina A. Urbanowicz, Arnaud Basle, Zhi-Peng Cai, Li Liu, Josef Voglmeir, Javier M. Melo Diaz, Samuel T. Benedict, Daniel I. R. Spencer, David N. Bolam, "Plant N-glycan breakdown by human gut Bacteroides", Proceedings Of The National Academy Of Sciences, 119 (2022), DOI: 10.1073/pnas.2208168119
- Dean Sherry, Ramesh Pandian, Yasien Sayed, "Non-active site mutations in the HIV protease: Diminished drug binding affinity is achieved through modulating the hydrophobic sliding mechanism", International Journal Of Biological Macromolecules, 217, 27 - 41 (2022), DOI: 10.1016/j.ijbiomac.2022.07.033
- Urvashi Sharma, Sandrine Vadon-Le Goff, Karl Harlos, Yuguang Zhao, Natacha Mariano, Cecile Bijakowski, Jean-Marie Bourhis, Catherine Moali, David J. S. Hulmes, Nushin Aghajari, "Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1)", Scientific Reports, 12 (2022), DOI: 10.1038/s41598-022-18795-4
- Thomas Hanke, Sebastian Mathea, Julia Woortman, Eidarus Salah, Benedict-Tilman Berger, Anthony Tumber, Risa Kashima, Akiko Hata, Bernhard Kuster, Susanne Müller, Stefan Knapp, "Development and characterization of type I, type II, and type III LIM-kinase chemical probes", Journal Of Medicinal Chemistry, 1550 (2022), DOI: 10.1021/acs.jmedchem.2c01106
- James M. Dunce, Lucy J. Salmon, Owen R. Davies, "Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip", Communications Biology, 5 (2022), DOI: 10.1038/s42003-022-03886-9
- Elsa Franco-Echevarria, Trevor J. Rutherford, Marc Fiedler, Caroline Dean, Mariann Bienz, "Plant vernalization proteins contain unusual PHD superdomains without histone H3 binding activity", Journal Of Biological Chemistry, 4 (2022), DOI: 10.1016/j.jbc.2022.102540
- Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar N. Haidar, Sylvie Moureau, Tomasz Dobrzycki, Conor Hayes, Christopher Rowley, Jorge Dias, Stephen Harper, Keir Barnbrook, Miriam Hock, Charlotte Coles, Wei Yang, Milos Aleksic, Aimee Bence Lin, Ross Robinson, Joe D. Dukes, Nathaniel Liddy, Marc Van Der Kamp, Gregory D. Plowman, Annelise Vuidepot, David K. Cole, Andrew D. Whale, Chandramouli Chillakuri, "Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-32811-1
- Richard W. Meek, Jacob Brockerman, Osei B. Fordwour, Wesley F. Zandberg, Gideon J. Davies, David J. Vocadlo, "The primary familial brain calcification-associated protein MYORG is an α-galactosidase with restricted substrate specificity", Plos Biology, 20 (2022), DOI: 10.1371/journal.pbio.3001764
- [Book Chapter] Rochelle D. Ahmed, Husam Sabah Auhim, Harley L. Worthy, D. Dafydd Jones, "Fluorescent proteins: crystallization, structural determination, and nonnatural amino acid incorporation" (2022), DOI: 10.1007/978-1-0716-2667-2_5
- Catriona M. A. Thompson, Richard H. Little, Clare E. M. Stevenson, David M. Lawson, Jacob G. Malone, "Structural insights into the mechanism of adaptive ribosomal modification by Pseudomonas RimK", Proteins: Structure, Function, And Bioinformatics (2022), DOI: 10.1002/prot.26429
- Christopher R. Smith, Svitlana Kulyk, Misbha Ud Din Ahmad, Valentina Arkhipova, James G. Christensen, Robin J. Gunn, Anthony Ivetac, John M. Ketcham, Jon Kuehler, J. David Lawson, Nicole C. Thomas, Xiaolun Wang, Matthew A. Marx, "Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits", Rsc Medicinal Chemistry, 33 (2022), DOI: 10.1039/D2MD00163B
- Midori Ishii, Patryk Ludzia, Gabriele Marciano, William Allen, Olga O. Nerusheva, Bungo Akiyoshi, "Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei", Molecular Biology Of The Cell (2022), DOI: 10.1091/mbc.E22-07-0269-T
- Jonathan S. Trimble, Rebecca Crawshaw, Florence J. Hardy, Colin W. Levy, Murray J. B. Brown, Douglas E. Fuerst, Derren J. Heyes, Richard Obexer, Anthony P. Green, "A designed photoenzyme for enantioselective [2+2]-cycloadditions", Nature (2022), DOI: 10.1038/s41586-022-05335-3
- Casper De Boer, Zachary Armstrong, Vincent A. J. Lit, Uri Barash, Gijs Ruijgrok, Ilanit Boyango, Merle M. Weitzenberg, Sybrin P. Schröder, Alexi J. C. Sarris, Nico J. Meeuwenoord, Pedro Bule, Yasmine Kayal, Neta Ilan, Jeroen D. C. Codée, Israel Vlodavsky, Herman S. Overkleeft, Gideon J. Davies, Liang Wu, "Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo", Proceedings Of The National Academy Of Sciences, 119 (2022), DOI: 10.1073/pnas.2203167119
- Alberto Zavarise, Shruthi Sridhar, Tiila-Riikka Kiema, Rikkert K. Wierenga, Mikael Widersten, "Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics", The Febs Journal (2022), DOI: 10.1111/febs.16603
- Jan Bláha, Tereza Skálová, Barbora Kalousková, Ondřej Skořepa, Denis Cmunt, Valéria Grobárová, Samuel Pazicky, Edita Poláchová, Celeste Abreu, Jan Stransky, Tomas Koval, Jarmila Duskova, Yuguang Zhao, Karl Harlos, Jindřich Hašek, Jan Dohnalek, Ondřej Vaněk, "Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-32577-6
- Mark A. Tye, N. Connor Payne, Catrine Johansson, Kritika Singh, Sofia A. Santos, Lọla Fagbami, Akansha Pant, Kayla Sylvester, Madeline R. Luth, Sofia Marques, Malcolm Whitman, Maria M. Mota, Elizabeth A. Winzeler, Amanda K. Lukens, Emily R. Derbyshire, Udo Oppermann, Dyann F. Wirth, Ralph Mazitschek, "Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-32630-4
- Gavin W. Collie, Louise Barlind, Sana Bazzaz, Ulf Börjesson, Ian L. Dale, Jeremy S. Disch, Sevan Habeshian, Rachael Jetson, Puneet Khurana, Andrew Madin, Iacovos N. Michaelides, Ling Peng, Arjan Snijder, Christopher J. Stubbs, "Discovery of a selective c-MET inhibitor with a novel binding mode", Bioorganic & Medicinal Chemistry Letters, 12 (2022), DOI: 10.1016/j.bmcl.2022.128948
- Herman K. H. Fung, Shelley Grimes, Alexis Huet, Robert L. Duda, Maria Chechik, Joseph Gault, Carol V. Robinson, Roger W. Hendrix, Paul J. Jardine, James F. Conway, Christoph G.. Baumann, Alfred A. Antson, "Structural basis of DNA packaging by a ring-type ATPase from an archetypal viral system", Nucleic Acids Research, 50, 8719 - 8732 (2022), DOI: 10.1093/nar/gkac647
- Lina Yan, Haohao Dong, Huanyu Li, Xingyu Liu, Zixin Deng, Changjiang Dong, Zhengyu Zhang, "Uncovering lipopolysaccharide regulation in bacteria via the critical lipid binding tunnel of YciS/YciM", Iscience (2022), DOI: 10.1016/j.isci.2022.104988
- Rachel Milne, Natalie Wiedemar, Victoriano Corpas-Lopez, Eoin Moynihan, Richard J. Wall, Alice Dawson, David A. Robinson, Sharon M. Shepherd, Robert J. Smith, Irene Hallyburton, John M. Post, Karen Dowers, Leah S. Torrie, Ian H. Gilbert, Beatriz Baragaña, Stephen Patterson, Susan Wyllie, "Toolkit of approaches to support target-focused drug discovery for Plasmodium falciparum lysyl tRNA synthetase", Acs Infectious Diseases (2022), DOI: 10.1021/acsinfecdis.2c00364
- Maria Petrosino, Karim Zuhra, Jola Kopec, Andrew Hutchin, Csaba Szabo, Tomas Majtan, "H2S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine", Cellular And Molecular Life Sciences, 79 (2022), DOI: 10.1007/s00018-022-04479-9
- Huiyong Ma, James B. Murray, Huadong Luo, Xuemin Cheng, Qiuxia Chen, Chao Song, Cong Duan, Ping Tan, Lifang Zhang, Jian Liu, Barry A. Morgan, Jin Li, Jinqiao Wan, Lisa M. Baker, William Finnie, Lucie Guetzoyan, Richard Harris, Nicole Hendrickson, Natalia Matassova, Heather Simmonite, Julia Smith, Roderick E. Hubbard, Guansai Liu, "PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery", Rsc Medicinal Chemistry, 15 (2022), DOI: 10.1039/D2MD00197G
- Yao Zhou, Kaizhou Yan, Qijian Qin, Olawale G. Raimi, Chao Du, Bin Wang, Chukwuemeka Samson Ahamefule, Bartosz Kowalski, Cheng Jin, Daniel M. F. Van Aalten, Wenxia Fang, "Phosphoglucose isomerase is important for Aspergillus fumigatuscell wall biogenesis", Mbio, 228 (2022), DOI: 10.1128/mbio.01426-22
- Elizabeth L. Bell, Ross Smithson, Siobhan Kilbride, Jake Foster, Florence J. Hardy, Saranarayanan Ramachandran, Aleksander A. Tedstone, Sarah J. Haigh, Arthur A. Garforth, Philip J. R. Day, Colin Levy, Michael P. Shaver, Anthony P. Green, "Directed evolution of an efficient and thermostable PET depolymerase", Nature Catalysis, 3 (2022), DOI: 10.1038/s41929-022-00821-3
- Raphael Reinbold, Ingvild C. Hvinden, Patrick Rabe, Ryan A. Herold, Alina Finch, James Wood, Melissa Morgan, Maximillian Staudt, Ian J. Clifton, Fraser A. Armstrong, James S. O. Mccullagh, Jo Redmond, Chiara Bardella, Martine I. Abboud, Christopher J. Schofield, "Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-32436-4
- Laurine Ducrot, Megan Bennett, Gwenaëlle André-Leroux, Eddy Elisée, Sacha Marynberg, Aurélie Fossey-Jouenne, Anne Zaparucha, Gideon Grogan, Carine Vergne-Vaxelaire, "Expanding the substrate scope of Native Amine Dehydrogenases through in silico structural exploration and targeted protein engineering", Chemcatchem (2022), DOI: 10.1002/cctc.202200880
- Maria Giulia Nizi, Mirko M. Maksimainen, Sudarshan Murthy, Serena Massari, Juho Alaviuhkola, Barbara E. Lippok, Sven T. Sowa, Albert Galera-Prat, Renata Prunskaite-Hyyryläinen, Bernhard Lüscher, Patricia Korn, Lari Lehtio, Oriana Tabarrini, "Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15", European Journal Of Medicinal Chemistry, 237 (2022), DOI: 10.1016/j.ejmech.2022.114362
- Christian M. Orr, Hayden Fisher, Xiaojie Yu, Claude H.-T. Chan, Yunyun Gao, Patrick J. Duriez, Steven G. Booth, Isabel Elliott, Tatyana Inzhelevskaya, Ian Mockridge, Christine A. Penfold, Armin Wagner, Martin J. Glennie, Ann L. White, Jonathan W. Essex, Arwen R. Pearson, Mark S. Cragg, Ivo Tews, "Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility", Science Immunology, 7 (2022), DOI: 10.1126/sciimmunol.abm3723
- Halina Mikolajek, Miriam Weckener, Z. Faidon Brotzakis, Jiandong Huo, Evmorfia V. Dalietou, Audrey Le Bas, Pietro Sormanni, Peter J. Harrison, Philip N. Ward, Steven Truong, Lucile Moynie, Daniel K. Clare, Maud Dumoux, Joshua Dormon, Chelsea Norman, Naveed Hussain, Vinod Vogirala, Raymond J. Owens, Michele Vendruscolo, James Naismith, "Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes", Proceedings Of The National Academy Of Sciences, 119 (2022), DOI: 10.1073/pnas.2205412119
- Stefanie Neun, Paul Brear, Eleanor Campbell, Theodora Tryfona, Kamel El Omari, Armin Wagner, Paul Dupree, Marko Hyvonen, Florian Hollfelder, "Functional metagenomic screening identifies an unexpected β-glucuronidase", Nature Chemical Biology, 48 (2022), DOI: 10.1038/s41589-022-01071-x
- Patrick Rabe, Carla C. Walla, Noelle K. Goodyear, Jordan Welsh, Rebecca Southwart, Ian Clifton, James D. S. Linyard, Anthony Tumber, Tim D. W. Claridge, William K. Myers, Christopher J. Schofield, "Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase", Journal Of Biological Chemistry, 35 (2022), DOI: 10.1016/j.jbc.2022.102249
- Sophia David, Joshua L. C. Wong, Julia Sanchez-Garrido, Hok-Sau Kwong, Wen Wen Low, Fabio Morecchiato, Tommaso Giani, Gian Maria Rossolini, Stephen J. Brett, Abigail Clements, Konstantinos Beis, David M. Aanensen, Gad Frankel, "Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae", Plos Pathogens, 18 (2022), DOI: 10.1371/journal.ppat.1010334
- Philip C. Simister, Ellen C. Border, João F. Vieira, Nicholas J. Pumphrey, "Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy", Journal For Immunotherapy Of Cancer, 10 (2022), DOI: 10.1136/jitc-2022-004600
- Daniel Kleiner, Ziva Shapiro Tuchman, Fannia Shmulevich, Anat Shahar, Raz Zarivach, Mickey Kosloff, Shimon Bershtein, "Evolution of homo‐oligomerization of methionine S‐adenosyltransferases is replete with structure–function constrains", Protein Science, 31 (2022), DOI: 10.1002/pro.4352
- Arianna Esposito Verza, Riccardo Miggiano, Fabrizio Lombardo, Bruno Arcà, Beatrice Purghé, Erika Del Grosso, Ubaldina Galli, Menico Rizzi, Franca Rossi, "Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues", Current Research In Structural Biology, D66 (2022), DOI: 10.1016/j.crstbi.2022.07.001
- Lucile Moynie, Françoise Hoegy, Stefan Milenkovic, Mathilde Munier, Aurélie Paulen, Véronique Gasser, Aline L. Faucon, Nicolas Zill, James H. Naismith, Matteo Ceccarelli, Isabelle J. Schalk, Gaëtan L. A. Mislin, "Hijacking of the enterobactin pathway by a synthetic catechol vector designed for oxazolidinone antibiotic delivery in Pseudomonas aeruginosa", Acs Infectious Diseases (2022), DOI: 10.1021/acsinfecdis.2c00202
- Eric T. Baldwin, Matthias Götte, Egor P. Tchesnokov, Eddy Arnold, Margit Hagel, Charles Nichols, Pam Dossang, Marieke Lamers, Paul Wan, Stefan Steinbacher, Donna L. Romero, "Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition", Proceedings Of The National Academy Of Sciences, 119 (2022), DOI: 10.1073/pnas.2200260119
- Frederick W. Goldberg, Attilla K. T. Ting, David Beattie, Gillian M. Lamont, Charlene Fallan, M. Raymond V. Finlay, Beth Williamson, Marianne Schimpl, Alexander R. Harmer, Oladipupo B. Adeyemi, Pär Nordell, Anna S. Cronin, Mercedes Vazquez-Chantada, Derek Barratt, Antonio Ramos-Montoya, Elaine B. Cadogan, Barry R. Davies, "Optimization of hERG and pharmacokinetic properties for basic dihydro-8H-purin-8-one inhibitors of DNA-PK", Acs Medicinal Chemistry Letters (2022), DOI: 10.1021/acsmedchemlett.2c00172
- Riccardo Zambelloni, Katherine S. H. Beckham, Hong-Jin Wu, Mikael Elofsson, Rudi Marquez, Mads Gabrielsen, Andrew Roe, "Crystal structures of WrbA, a spurious target of the salicylidene acylhydrazide inhibitors of type III secretion in Gram-negative pathogens, and verification of improved specificity of next-generation compounds", Microbiology, 168 (2022), DOI: 10.1099/mic.0.001211
- Ysobel R. Baker, Cameron Thorpe, Jinfeng Chen, Laura M. Poller, Lina Cox, Pawan Kumar, Wooi F. Lim, Lillian Lie, Graham Mcclorey, Sven Epple, Daniel Singleton, Michael A. Mcdonough, Jack S. Hardwick, Kirsten E. Christensen, Matthew J. A. Wood, James P. Hall, Afaf H. El-Sagheer, Tom Brown, "An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-31636-2
- Mark D. Andrews, Kevin N. Dack, Marcel J. De Groot, Maja Lambert, Carl J. Sennbro, Mogens Larsen, Martin Stahlhut, "Discovery of an oral, rule of 5 compliant, interleukin 17A protein–protein interaction modulator for the potential treatment of psoriasis and other inflammatory diseases", Journal Of Medicinal Chemistry, 65, 8828 - 8842 (2022), DOI: 10.1021/acs.jmedchem.2c00422
- Alevtina Mikhaylina, Amira Z. Ksibe, Rachael C. Wilkinson, Darbi Smith, Eleanor Marks, James P. C. Coverdale, Vilmos Fulop, David J. Scanlan, Claudia A. Blindauer, "A single sensor controls large variations in zinc quotas in a marine cyanobacterium", Nature Chemical Biology, 5 (2022), DOI: 10.1038/s41589-022-01051-1
- Lucy C. Walters, Daniel Rozbesky, Karl Harlos, Max Quastel, Hong Sun, Sebastian Springer, Robert P. Rambo, Fiyaz Mohammed, E. Yvonne Jones, Andrew J. Mcmichael, Geraldine M. Gillespie, "Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes", Cell Reports, 39 (2022), DOI: 10.1016/j.celrep.2022.110959
- Samuel L. Freeman, Vera Skafar, Hanna Kwon, Alistair J. Fielding, Peter C. E. Moody, Alejandra Martínez, Federico Issoglio, Lucas Inchausti, Pablo Smircich, Ari Zeida, Lucía Piacenza, Rafael Radi, Emma L. Raven, "Crystal structure of Trypanosoma cruzi heme peroxidase and characterisation of its substrate specificity and compound I intermediate", Journal Of Biological Chemistry (2022), DOI: 10.1016/j.jbc.2022.102204
- [Thesis] Lily Jane Goodyer Sait, "Structural and functional studies of cannabidiol interactions with voltage-gated sodium channels" (2022)
- Ina Pöhner, Antonio Quotadamo, Joanna Panecka-Hofman, Rosaria Luciani, Matteo Santucci, Pasquale Linciano, Giacomo Landi, Flavio Di Pisa, Lucia Dello Iacono, Cecilia Pozzi, Stefano Mangani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Nuno Santarem, Anabela Cordeiro-Da-Silva, Maria P. Costi, Alberto Venturelli, Rebecca C. Wade, "Multitarget, selective compound design yields potent inhibitors of a kinetoplastid pteridine reductase 1", Journal Of Medicinal Chemistry, 51 (2022), DOI: 10.1021/acs.jmedchem.2c00232
- Scott A. White, Andrew J. Christofferson, Alastair I. Grainger, Martin A. Day, David Jarrom, Antonio E. Graziano, Peter F. Searle, Eva I. Hyde, "The 3D ‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism", Febs Letters (2022), DOI: 10.1002/1873-3468.14413
- Owen A. Davis, Kwai-Ming J. Cheung, Alfie Brennan, Matthew G. Lloyd, Matthew J. Rodrigues, Olivier A. Pierrat, Gavin W. Collie, Yann-Vai Le Bihan, Rosemary Huckvale, Alice C. Harnden, Ana Varela, Michael D. Bright, Paul Eve, Angela Hayes, Alan T. Henley, Michael D. Carter, P. Craig Mcandrew, Rachel Talbot, Rosemary Burke, Rob Van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Mirco Meniconi, Benjamin R. Bellenie, Swen Hoelder, "Optimizing shape complementarity enables the discovery of potent tricyclic BCL6 inhibitors", Journal Of Medicinal Chemistry (2022), DOI: 10.1021/acs.jmedchem.1c02174
- Rosemary Huckvale, Alice C. Harnden, Kwai-Ming J. Cheung, Olivier A. Pierrat, Rachel Talbot, Gary M. Box, Alan T. Henley, Alexis K. De Haven Brandon, Albert E. Hallsworth, Michael D. Bright, Hafize Aysin Akpinar, Daniel S. J. Miller, Dalia Tarantino, Sharon Gowan, Angela Hayes, Emma A. Gunnell, Alfie Brennan, Owen A. Davis, Louise D. Johnson, Selby De Klerk, Craig Mcandrew, Yann-Vai Le Bihan, Mirco Meniconi, Rosemary Burke, Vladimir Kirkin, Rob L. M. Van Montfort, Florence I. Raynaud, Olivia W. Rossanese, Benjamin R. Bellenie, Swen Hoelder, "Improved binding affinity and pharmacokinetics enable sustained degradation of BCL6 in vivo", Journal Of Medicinal Chemistry (2022), DOI: 10.1021/acs.jmedchem.1c02175
- Ana S. Luis, Arnaud Basle, Dominic P. Byrne, Gareth S. A. Wright, James A. London, Chunsheng Jin, Niclas G. Karlsson, Gunnar C. Hansson, Patrick A. Eyers, Mirjam Czjzek, Tristan Barbeyron, Edwin A. Yates, Eric C. Martens, Alan Cartmell, "Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota", Nature Chemical Biology, 19 (2022), DOI: 10.1038/s41589-022-01039-x
- Aekkachai Tuekprakhon, Jiandong Huo, Rungtiwa Nutalai, Aiste Dijokaite-Guraliuc, Daming Zhou, Helen M. Ginn, Muneeswaran Selvaraj, Chang Liu, Alexander J. Mentzer, Piyada Supasa, Helen M. E. Duyvesteyn, Raksha Das, Donal Skelly, Thomas G. Ritter, Ali Amini, Sagida Bibi, Sandra Adele, Sile Ann Johnson, Bede Constantinides, Hermione Webster, Nigel Temperton, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Derrick Crook, Andrew J. Pollard, Teresa Lambe, Philip Goulder, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, David I. Stuart, Gavin R. Screaton, Christopher Conlon, Alexandra Deeks, John Frater, Lisa Frending, Siobhan Gardiner, Anni Jämsén, Katie Jeffery, Tom Malone, Eloise Phillips, Lucy Rothwell, Lizzie Stafford, "Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum", Cell (2022), DOI: 10.1016/j.cell.2022.06.005
- Tomoyuki Hatano, Saravanan Palani, Dimitra Papatziamou, Ralf Salzer, Diorge P. Souza, Daniel Tamarit, Mehul Makwana, Antonia Potter, Alexandra Haig, Wenjue Xu, David Townsend, David Rochester, Dom Bellini, Hamdi M. A. Hussain, Thijs J. G. Ettema, Jan Lowe, Buzz Baum, Nicholas P. Robinson, Mohan Balasubramanian, "Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-30656-2
- Gyles E. Cozier, Emma C. Newby, Sylva L. U. Schwager, R. Elwyn Isaac, Edward D. Sturrock, K. Ravi Acharya, "Structural basis for the inhibition of human angiotensin‐1 converting enzyme by fosinoprilat", The Febs Journal (2022), DOI: 10.1111/febs.16543
- Sigurbjörn Markússon, Erik I. Hallin, Helene J. Bustad, Arne Raasakka, Ju Xu, Gopinath Muruganandam, Remy Loris, Aurora Martinez, Clive R. Bramham, Petri Kursula, "High-affinity anti-Arc nanobodies provide tools for structural and functional studies", Plos One, 17 (2022), DOI: 10.1371/journal.pone.0269281
- Isabella M. Acquistapace, Emma J. Thompson, Imke Kühn, Mike R. Bedford, Charles A. Brearley, Andrew M. Hemmings, "Insights to the structural basis for the stereospecificity of the Escherichia coli phytase, AppA", International Journal Of Molecular Sciences, 23 (2022), DOI: 10.3390/ijms23116346
- Elise M. Ling, Arnaud Basle, Ian G. Cowell, Bert Van Den Berg, Tim R. Blower, Caroline A. Austin, "A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193", Structure, 369 (2022), DOI: 10.1016/j.str.2022.05.009
- Prasun Kumar, Neil G. Paterson, Jonathan Clayden, Derek N. Woolfson, "De novo design of discrete, stable 310-helix peptide assemblies", Nature, 37 (2022), DOI: 10.1038/s41586-022-04868-x
- Jhon A. Vargas, Diego A. Leonardo, Humberto D'Muniz Pereira, Adriana R. Lopes, Hicler N. Rodriguez, Marianela Cobos, Jorge L. Marapara, Juan C. Castro, Richard C. Garratt, "Structural characterization of l-galactose dehydrogenase: an essential enzyme for vitamin C biosynthesis", Plant And Cell Physiology (2022), DOI: 10.1093/pcp/pcac090
- Hannah Scott, Gideon J. Davies, Zachary Armstrong, "The structure of Phocaeicola vulgatus sialic acid acetylesterase", Acta Crystallographica Section D Structural Biology, 78 (2022), DOI: 10.1107/S2059798322003357
- Alissa Bleem, Eugene Kuatsjah, Gerald N. Presley, Daniel J. Hinchen, Michael Zahn, David C. Garcia, William E. Michener, Gerhard König, Konstantinos Tornesakis, Marco N. Allemann, Richard J. Giannone, John E. Mcgeehan, Gregg T. Beckham, Joshua K. Michener, "Discovery, characterization, and metabolic engineering of Rieske non-heme iron monooxygenases for guaiacol O-demethylation", Chem Catalysis, 55 (2022), DOI: 10.1016/j.checat.2022.04.019
- Pauline A. Lang, Ritu Raj, Anthony Tumber, Christopher T. Lohans, Patrick Rabe, Carol V. Robinson, Jurgen Brem, Christopher J. Schofield, "Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors", Proceedings Of The National Academy Of Sciences, 119 (2022), DOI: 10.1073/pnas.2117310119
- Rungtiwa Nutalai, Daming Zhou, Aekkachai Tuekprakhon, Helen M. Ginn, Piyada Supasa, Chang Liu, Jiandong Huo, Alexander J. Mentzer, Helen M. E. Duyvesteyn, Aiste Dijokaite-Guraliuc, Donal Skelly, Thomas G. Ritter, Ali Amini, Sagida Bibi, Sandra Adele, Sile Ann Johnson, Bede Constantinides, Hermione Webster, Nigel Temperton, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Derrick Crook, Andrew J. Pollard, Teresa Lambe, Philip Goulder, Neil G. Paterson, Mark A. Williams, David R. Hall, Juthathip Mongkolsapaya, Elizabeth E. Fry, Wanwisa Dejnirattisai, Jingshan Ren, David I. Stuart, Gavin R. Screaton, Christopher Conlon, Alexandra Deeks, John Frater, Lisa Frending, Siobhan Gardiner, Anni Jämsén, Katie Jeffery, Tom Malone, Eloise Phillips, Lucy Rothwell, Lizzie Stafford, "Potent cross-reactive antibodies following Omicron breakthrough in vaccinees", Cell (2022), DOI: 10.1016/j.cell.2022.05.014
- Audrey Le Bas, Halina Mikolajek, Jiandong Huo, Chelsea Norman, Joshua Dormon, James Naismith, Raymond Owens, "Production and crystallization of nanobodies in complex with the receptor binding domain of the SARS-COV-2 spike protein", Bio-Protocol, 12 (2022), DOI: 10.21769/BioProtoc.4406
- Arthur W. H. Li, Katerina Zabrady, Lewis J. Bainbridge, Matej Zabrady, Sehr Naseem-Khan, Madison B. Berger, Peter Kolesar, G. Andrés Cisneros, Aidan J. Doherty, "Molecular basis for the initiation of DNA primer synthesis", Nature, 43 (2022), DOI: 10.1038/s41586-022-04695-0
- Tika R. Malla, Lennart Brewitz, Dorian-Gabriel Muntean, Hiba Aslam, C. David Owen, Eidarus Salah, Anthony Tumber, Petra Lukacik, Claire Strain-Damerell, Halina Mikolajek, Martin Walsh, Christopher J. Schofield, "Penicillin derivatives inhibit the SARS-COV-2 main protease by reaction with its nucleophilic cysteine", Journal Of Medicinal Chemistry, 49 (2022), DOI: 10.1021/acs.jmedchem.1c02214
- Philip Hinchliffe, Catherine L. Tooke, Christopher R. Bethel, Benlian Wang, Christopher Arthur, Kate J. Heesom, Stuart Shapiro, Daniela M. Schlatzer, Krisztina M. Papp-Wallace, Robert A. Bonomo, James Spencer, "Penicillanic acid sulfones inactivate the extended-spectrum β-lactamase CTX-M-15 through formation of a serine-lysine cross-link: an alternative mechanism of β-lactamase inhibition", Mbio (2022), DOI: 10.1128/mbio.01793-21
- Steven J. Berardinelli, Alexander Eletsky, Jessika Valero-González, Atsuko Ito, Rajashri Manjunath, Ramon Hurtado-Guerrero, James R. Prestegard, Robert J. Woods, Robert S. Haltiwanger, "O-Fucosylation stabilizes the TSR3 motif in Thrombospondin-1 by interacting with nearby amino acids and protecting a disulfide bond", Journal Of Biological Chemistry, 36 (2022), DOI: 10.1016/j.jbc.2022.102047
- Nikolaos Georgakopoulos, Sandeep Talapatra, Dina Dikovskaya, Sharadha Dayalan Naidu, Maureen Higgins, Jemma Gatliff, Aysel Ayhan, Roxani Nikoloudaki, Marjolein Schaap, Klara Valko, Farideh Javid, Albena T. Dinkova-Kostova, Frank Kozielski, Geoffrey Wells, "Phenyl Bis-sulfonamide Keap1-Nrf2 protein–protein interaction inhibitors with an alternative binding mode", Journal Of Medicinal Chemistry (2022), DOI: 10.1021/acs.jmedchem.2c00457
- Haiyang Wu, Emmanuelle Crost, David Owen, Wouter Van Bakel, Ana Martinez-Gascuena, Martin Walsh, Nathalie Juge, "Ruminococcus gnavus GH98 substrate specificity to blood group A antigen contributes to mucin glycan foraging", Access Microbiology, 4 (2022), DOI: 10.1099/acmi.ac2021.po0311
- Moshe Giladi, Michal Lisnyansky Bar-El, Pavla Vaňková, Alisa Ferofontov, Emelia Melvin, Suha Alkaderi, Daniel Kavan, Boris Redko, Elvira Haimov, Reuven Wiener, Petr Man, Yoni Haitin, "Structural basis for long-chain isoprenoid synthesis by cis-prenyltransferases", Science Advances, 8 (2022), DOI: 10.1126/sciadv.abn1171
- Sherine E. Thomas, William J. Mccarthy, Jamal El Bakali, Karen P. Brown, So Yeon Kim, Michal Blaszczyk, Vitor Mendes, Chris Abell, R. Andres Floto, Anthony G. Coyne, Tom L. Blundell, "Structural characterization of Mycobacterium abscessus phosphopantetheine adenylyl transferase ligand interactions: implications for fragment-based drug design", Frontiers In Molecular Biosciences, 9 (2022), DOI: 10.3389/fmolb.2022.880432
- Rasheduzzaman Chowdhury, Martine I. Abboud, James Wiley, Anthony Tumber, Suzana Markolovic, Christopher J. Schofield, "Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans", Scientific Reports, 12 (2022), DOI: 10.1038/s41598-022-10028-y
- Mark Van Breugel, Ivan Rosa E Silva, Antonina Andreeva, "Structural validation and assessment of AlphaFold2 predictions for centrosomal and centriolar proteins and their complexes", Communications Biology, 5 (2022), DOI: 10.1038/s42003-022-03269-0
- Nathan R. Zaccai, Zuzana Kadlecova, Veronica Kane Dickson, Kseniya Korobchevskaya, Jan Kamenicky, Oleksiy Kovtun, Perunthottathu K. Umasankar, Antoni G. Wrobel, Jonathan G. G. Kaufman, Sally R. Gray, Kun Qu, Philip R. Evans, Marco Fritzsche, Filip Sroubek, Stefan Höning, John A. G. Briggs, Bernard T. Kelly, David J. Owen, Linton M. Traub, "FCHO controls AP2’s initiating role in endocytosis through a PtdIns(4,5)P2-dependent switch", Science Advances, 8 (2022), DOI: 10.1126/sciadv.abn2018
- Katy A. S. Cornish, Joanna Lange, Arnthór Aevarsson, Ehmke Pohl, "CPR-C4 is a highly conserved novel protease from the Candidate Phyla Radiation with remote structural homology to human vasohibins", Journal Of Biological Chemistry, 172 (2022), DOI: 10.1016/j.jbc.2022.101919
- Alice R. Cross, Sumita Roy, Mirella Vivoli Vega, Martin Rejzek, Sergey A. Nepogodiev, Matthew Cliff, Debbie Salmon, Michail N. Isupov, Robert A. Field, Joann L. Prior, Nicholas J. Harmer, "Spinning sugars in antigen biosynthesis: characterization of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases", Journal Of Biological Chemistry, 11 (2022), DOI: 10.1016/j.jbc.2022.101903
- Chloe R. Koulouris, Sian E. Gardiner, Tessa K. Harris, Karen T. Elvers, S. Mark Roe, Jason A. Gillespie, Simon E. Ward, Olivera Grubisha, Robert A. Nicholls, John R. Atack, Benjamin D. Bax, "Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase", Communications Biology, 5 (2022), DOI: 10.1038/s42003-022-03264-5
- Manmohan Sharma, Nachiappan Mutharasappan, Yogavel Manickam, Karl Harlos, Bruno Melillo, Eamon Comer, Heena Tabassum, Suhel Parvez, Stuart L. Schreiber, Amit Sharma, "Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development", Structure, 66 (2022), DOI: 10.1016/j.str.2022.03.017
- Thomas W. Thorpe, James R. Marshall, Vanessa Harawa, Rebecca E. Ruscoe, Anibal Cuetos, James D. Finnigan, Antonio Angelastro, Rachel S. Heath, Fabio Parmeggiani, Simon J. Charnock, Roger M. Howard, Rajesh Kumar, David S. B. Daniels, Gideon Grogan, Nicholas J. Turner, "Multifunctional biocatalyst for conjugate reduction and reductive amination", Nature, 604, 86 - 91 (2022), DOI: 10.1038/s41586-022-04458-x
- Shamsudeen Umar Dandare, Maria Håkansson, L. Anders Svensson, David J. Timson, Christopher C. R. Allen, "Expression, purification and crystallization of a novel metagenome-derived salicylaldehyde dehydrogenase from Alpine soil", Acta Crystallographica Section F Structural Biology Communications, 78 (2022), DOI: 10.1107/S2053230X22002345
- Stanley Makumire, Siyun Su, Brandon William Weber, Jeremy Woodward, Serah Wangari Kimani, Roger Hunter, Bryan Trevor Sewell, "The structures of the C146A variant of the amidase from Pyrococcus horikoshii bound to glutaramide and acetamide suggest the basis of amide recognition", Journal Of Structural Biology, 60 (2022), DOI: 10.1016/j.jsb.2022.107859
- Wei Xu, Dawei Ni, Xiaodong Hou, Tjaard Pijning, Albert Guskov, Yijian Rao, Wanmeng Mu, "Crystal structure of levansucrase from the gram-negative bacterium Brenneria provides insights into its product size specificity", Journal Of Agricultural And Food Chemistry, 30 (2022), DOI: 10.1021/acs.jafc.2c01225
- Mark F. Maurer, Katherine E. Lewis, Joseph L. Kuijper, Dan Ardourel, Chelsea J. Gudgeon, Siddarth Chandrasekaran, Sherri L. Mudri, Kayla N. Kleist, Chris Navas, Martin F. Wolfson, Mark W. Rixon, Ryan Swanson, Stacey R. Dillon, Steven D. Levin, Yengo Raymond Kimbung, Masato Akutsu, Derek T. Logan, Björn Walse, Kristine M. Swiderek, Stanford L. Peng, "The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-29286-5
- Eleanor L. Atkinson, Jessica Iegre, Claudio D’amore, Paul Brear, Mauro Salvi, Marko Hyvonen, David R. Spring, "Development of small cyclic peptides targeting the CK2α/β interface", Chemical Communications, 58, 4791 - 4794 (2022), DOI: 10.1039/D2CC00707J
- Simranjeet Kaur, Nok Yin Tam, Michael A. Mcdonough, Christopher J. Schofield, Wei Shen Aik, "Mechanisms of substrate recognition and N 6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes", Nucleic Acids Research, 28 (2022), DOI: 10.1093/nar/gkac195
- Kane Mcquaid, Shuntaro Takahashi, Lena Baumgaertner, David J. Cardin, Neil G. Paterson, James P. Hall, Naoki Sugimoto, Christine J. Cardin, "Ruthenium polypyridyl complex bound to a unimolecular chair-form G-quadruplex", Journal Of The American Chemical Society, 75 (2022), DOI: 10.1021/jacs.2c00178
- Laurens Vandebroek, Hiroki Noguchi, Alexander Anyushin, Luc Van Meervelt, Arnout R. D. Voet, Tatjana N. Parac-Vogt, "Hierarchical self-assembly of a supramolecular protein-metal cage encapsulating a polyoxometalate guest", Crystal Growth & Design, 22, 1515 - 1520 (2022), DOI: 10.1021/acs.cgd.1c01138
- Changrong Ge, Sylvia Weisse, Bingze Xu, Doreen Dobritzsch, Johan Viljanen, Jan Kihlberg, Nhu-Nguyen Do, Nadine Schneider, Harald Lanig, Rikard Holmdahl, Harald Burkhardt, "Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor", Annals Of The Rheumatic Diseases, 81, 480 - 489 (2022), DOI: 10.1136/annrheumdis-2021-220500
- Anastassia L. Kantsadi, Georgios N. Hatzopoulos, Pierre Gönczy, Ioannis Vakonakis, "Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel", Structure, 41 (2022), DOI: 10.1016/j.str.2022.02.005
- Alexander J. D. Snow, Mahima Sharma, James P. Lingford, Yunyang Zhang, Janice W.-Y. Mui, Ruwan Epa, Ethan D. Goddard-Borger, Spencer J. Williams, Gideon J. Davies, "The sulfoquinovosyl glycerol binding protein SmoF binds and accommodates plant sulfolipids", Current Research In Structural Biology, 4 (2022), DOI: 10.1016/j.crstbi.2022.03.001
- Megan Bennett, Laurine Ducrot, Carine Vergne-Vaxelaire, Gideon Grogan, "Structure and mutation of the native amine dehydrogenase MATOUAmDH2", Chembiochem (2022), DOI: 10.1002/cbic.202200136
- Yogavel Manickam, Nipun Malhotra, Siddhartha Mishra, Palak Babbar, Abhishek Dusane, Benoît Laleu, Valeria Bellini, Mohamed-Ali Hakimi, Alexandre Bougdour, Amit Sharma, "Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development", Plos Pathogens, 18 (2022), DOI: 10.1371/journal.ppat.1010363
- Dapeng Li, Simon Brackenridge, Lucy C. Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W. Cain, Kevin Wiehe, Richard M. Scearce, Maggie Barr, Zekun Mu, Robert Parks, Max Quastel, Robert J. Edwards, Yunfei Wang, Wes Rountree, Kevin O. Saunders, Guido Ferrari, Persephone Borrow, E. Yvonne Jones, S. Munir Alam, Mihai L. Azoitei, Geraldine M. Gillespie, Andrew J. Mcmichael, Barton F. Haynes, "Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity", Communications Biology, 5 (2022), DOI: 10.1038/s42003-022-03183-5
- William M. Kincannon, Michael Zahn, Rita Clare, Jessica Lusty Beech, Ari Romberg, James Larson, Brian Bothner, Gregg T. Beckham, John E/ Mcgeehan, Jennifer L. Dubois, "Biochemical and structural characterization of an aromatic ring–hydroxylating dioxygenase for terephthalic acid catabolism", Proceedings Of The National Academy Of Sciences, 119 (2022), DOI: 10.1073/pnas.2121426119
- George W. Mobbs, Adli A. Aziz, Samuel R. Dix, G. Michael Blackburn, Sveta E. Sedelnikova, Thomas C. Minshull, Mark J. Dickman, Patrick Baker, Sheila Nathan, Mohd Firdaus Raih, David W. Rice, "Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1", Communications Biology, 5 (2022), DOI: 10.1038/s42003-022-03186-2
- Sven T. Sowa, Lari Lehtio, "The zinc-binding motif in tankyrases is required for the structural integrity of the catalytic ADP-ribosyltransferase domain", Open Biology, 12 (2022), DOI: 10.1098/rsob.210365
- Amalyn Nain-Perez, Anders Foller Füchtbauer, Liliana Håversen, Aleksei Lulla, Chunxia Gao, Josipa Matic, Leticia Monjas, Alexandra Rodríguez, Paul Brear, Woonghee Kim, Marko Hyvonen, Jan Borén, Adil Mardinoglu, Mathias Uhlen, Morten Grøtli, "Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase", European Journal Of Medicinal Chemistry, 41 (2022), DOI: 10.1016/j.ejmech.2022.114270
- Weng M. Ng, Mehmet Sahin, Stefanie A. Krumm, Jeffrey Seow, Antra Zeltina, Karl Harlos, Guido C. Paesen, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden, "Contrasting modes of new world arenavirus neutralization by immunization-elicited monoclonal antibodies", Mbio (2022), DOI: 10.1128/mbio.02650-21
- Zhuoyao Chen, Jinwei Zhang, Adrián R. Murillo-De-Ozores, María Castañeda-Bueno, Francesca D'Amico, Raphael Heilig, Charlotte E. Manning, Fiona J. Sorrell, Vincenzo D'Angiolella, Roman Fischer, Monique P. C. Mulder, Gerardo Gamba, Dario R. Alessi, Alex N. Bullock, "Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase", Biochemical Journal, 479, 661 - 675 (2022), DOI: 10.1042/BCJ20220019
- Tamas Yelland, Esther Garcia, Charles Parry, Dominika Kowalczyk, Marta Wojnowska, Andrea Gohlke, Matja Zalar, Kenneth Cameron, Gillian Goodwin, Qing Yu, Peng-Cheng Zhu, Yasmin Elmaghloob, Angelo Pugliese, Lewis Archibald, Andrew Jamieson, Yong Xiang Chen, Duncan Mcarthur, Justin Bower, Shehab Ismail, "Stabilization of the RAS:PDE6D complex is a novel strategy to inhibit RAS signaling", Journal Of Medicinal Chemistry, 12 (2022), DOI: 10.1021/acs.jmedchem.1c01265
- Robert J. Ragotte, David Pulido, Amelia M. Lias, Doris Quinkert, Daniel G. W. Alanine, Abhishek Jamwal, Hannah Davies, Adéla Nacer, Edward D. Lowe, Geoffrey W. Grime, Joseph J. Illingworth, Robert F. Donat, Elspeth F. Garman, Paul W. Bowyer, Matthew K. Higgins, Simon J. Draper, "Heterotypic interactions drive antibody synergy against a malaria vaccine candidate", Nature Communications, 13 (2022), DOI: 10.1038/s41467-022-28601-4
- Lauren B. Arendse, Gyles E. Cozier, Charles J. Eyermann, Gregory S. Basarab, Sylva L. Schwager, Kelly Chibale, K. Ravi Acharya, Edward D. Sturrock, "Probing the requirements for dual angiotensin-converting enzyme c-domain selective/neprilysin inhibition", Journal Of Medicinal Chemistry, 297 (2022), DOI: 10.1021/acs.jmedchem.1c01924
- Theresa Kissel, Lise Hafkenscheid, Joanneke C. Kwekkeboom, Changrong Ge, Linda M. Slot, Marco Cavallari, Yibo He, Karin A. Van Schie, Rochelle D. Vergroesen, Arieke S. B. Kampstra, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Carolien Koeleman, Lennard M. Voortman, Laura H. Heitman, Bingze Xu, Ger J. M. Pruijn, Manfred Wuhrer, Theo Rispens, Tom W. J. Huizinga, Hans Ulrich Scherer, Michael Reth, Rikard Holmdahl, Rene E. M. Toes, "Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation", Science Advances (2022), DOI: 10.1126/sciadv.abm1759
- Raquel Faba-Rodriguez, Yinghong Gu, Melissa Salmon, Giuseppe Dionisio, Henrik A. Brinch-Pedersen, Charles A. Brearley, Andrew M. Hemmings, "Structure of a cereal purple acid phytase provides new insights to phytate degradation in plants", Plant Communications (2022), DOI: 10.1016/j.xplc.2022.100305
- Angus J. Robertson, F. Aaron Cruz-Navarrete, Henry P. Wood, Nikita Vekaria, Andrea M. Hounslow, Claudine Bisson, Matthew J. Cliffe, Nicola J. Baxter, Jonathan P. Waltho, "An enzyme with high catalytic proficiency utilizes distal site substrate binding energy to stabilize the closed state but at the expense of substrate inhibition", Acs Catalysis (2022), DOI: 10.1021/acscatal.1c05524
- Helen K. Boffey, Timothy P. C. Rooney, Henriette M. G. Willems, Simon Edwards, Christopher Green, Tina Howard, Derek Ogg, Tamara Romero, Duncan E. Scott, David Winpenny, James Duce, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews, "Development of selective phosphatidylinositol 5-phosphate 4-kinase γ inhibitors with a non-ATP-competitive, allosteric binding mode", Journal Of Medicinal Chemistry, 52 (2022), DOI: 10.1021/acs.jmedchem.1c01819
- Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pal Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday, "Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress", Nature Cancer, 3, 156 - 172 (2022), DOI: 10.1038/s43018-022-00331-y
- Jose Antonio Manso, Tamara Marcos, Virginia Ruiz-Martín, Javier Casas, Pablo Alcon, Mariano Sánchez Crespo, Yolanda Bayón, Jose M. De Pereda, Andrés Alonso, "PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders", Cellular And Molecular Life Sciences, 79 (2022), DOI: 10.1007/s00018-022-04173-w
- Arathy Jose, Daniel Guest, Remi Legay, Graham J. Tizzard, Simon Coles, Mariliza Derveni, Edward Wright, Lester Marrison, Alpha A. Lee, Aaron Morris, Matt Robinson, Frank Von Delft, Daren Fearon, Lizbe Koekemoer, Tetiana Matviuk, Anthony Aimon, Christopher J. Schofield, Tika R. Malla, Nir London, Barnaby W. Greenland, Mark C. Bagley, John Spencer, "Expanding the repertoire of low-molecular-weight pentafluorosulfanyl-substituted scaffolds", Chemmedchem, 59 (2022), DOI: 10.1002/cmdc.202100641
- Charles Eldrid, Mire Zloh, Constantina Fotinou, Tamas Yelland, Lefan Yu, Filipa Mota, David L. Selwood, Snezana Djordjevic, "VEGFA, B, C: implications of the C-terminal sequence variations for the interaction with neuropilins", Biomolecules, 12 (2022), DOI: 10.3390/biom12030372
- Claire Barber, Victoria Arena De Souza, Rachel L. Paterson, Magdalena Martin-Urdiroz, Nitha Charles Mulakkal, Velupillai Srikannathasan, Mary Connolly, Gwilym Phillips, Tein Foong-Leong, Robert Pengelly, Vijaykumar Karuppiah, Tressan Grant, Marcin Dembek, Anil Verma, Dawn Gibbs-Howe, Thomas H. Blicher, Andrew Knox, Ross A. Robinson, David K. Cole, Sarah Leonard, "Structure‐guided stabilization of pathogen‐derived peptide‐HLA‐E complexes using non‐natural amino acids conserves native TCR recognition", European Journal Of Immunology (2022), DOI: 10.1002/eji.202149745
- Wanwisa Dejnirattisai, Jiandong Huo, Daming Zhou, Jiří Zahradník, Piyada Supasa, Chang Liu, Helen M. E. Duyvesteyn, Helen M. Ginn, Alexander J. Mentzer, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Aiste Dijokaite, Suman Khan, Ori Avinoam, Mohammad Bahar, Donal Skelly, Sandra Adele, Sile Ann Johnson, Ali Amini, Thomas Ritter, Chris Mason, Christina Dold, Daniel Pan, Sara Assadi, Adam Bellass, Nikki Omo-Dare, David Koeckerling, Amy Flaxman, Daniel Jenkin, Parvinder K. Aley, Merryn Voysey, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes Da Costa, Paola Cristina Resende, Alex Pauvolid-Correa, Marilda M. Siqueira, Vicky Baillie, Natali Serafin, Gaurav Kwatra, Kelly Da Silva, Shabir A. Madhi, Marta C. Nunes, Tariq Malik, Peter J. M. Openshaw, J. Kenneth Baillie, Malcolm G. Semple, Alain R. Townsend, Kuan-Ying A. Huang, Tiong Kit Tan, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Bede Constantinides, Hermione Webster, Derrick Crook, Andrew J. Pollard, Teresa Lambe, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, Gideon Schreiber, David I. Stuart, Gavin R. Screaton, "SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses", Cell (2022), DOI: 10.1016/j.cell.2021.12.046
- Changrong Ge, Dongmei Tong, Erik Lönnblom, Bibo Liang, Weiwei Cai, Cecilia Fahlquist-Hagert, Taotao Li, Alf Kastbom, Inger Gjertsson, Doreen Dobritzsch, Rikard Holmdahl, "Antibodies to cartilage oligomeric matrix protein are pathogenic in mice and may be clinically relevant in rheumatoid arthritis", Arthritis & Rheumatology (2022), DOI: 10.1002/art.42072
- Jeremy R. Keown, Zihan Zhu, Loic Carrique, Haitian Fan, Alexander P. Walker, Itziar Serna Martin, Els Pardon, Jan Steyaert, Ervin Fodor, Jonathan M. Grimes, "Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies", Nature Communications, 13 (2022), DOI: 10.1038/s41467-021-27950-w
- Eugene Kuatsjah, Christopher W. Johnson, Davinia Salvachúa, Allison Z. Werner, Michael Zahn, Caralyn J. Szostkiewicz, Christine A. Singer, Graham Dominick, Ikenna Okekeogbu, Stefan J. Haugen, Sean P. Woodworth, Kelsey J. Ramirez, Richard J. Giannone, Robert L. Hettich, John E. Mcgeehan, Gregg T. Beckham, "Debottlenecking 4-hydroxybenzoate hydroxylation in Pseudomonas putida KT2440 improves muconate productivity from p-coumarate", Metabolic Engineering, 34 (2022), DOI: 10.1016/j.ymben.2021.12.010
- Federica Centorrino, Blaž Andlovic, Peter Cossar, Luc Brunsveld, Christian Ottmann, "Fragment-based exploration of the 14-3-3/Amot-p130 interface", Current Research In Structural Biology, 4, 21 - 28 (2022), DOI: 10.1016/j.crstbi.2021.12.003
- Martyn Frederickson, Irwin R. Selvam, Dimitrios Evangelopoulos, Kirsty J. Mclean, Mona M. Katariya, Richard B. Tunnicliffe, Bethany Campbell, Madeline E. Kavanagh, Sitthivut Charoensutthivarakul, Richard T. Blankley, Colin W. Levy, Luiz Pedro S. De Carvalho, David Leys, Andrew W. Munro, Anthony G. Coyne, Chris Abell, "A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)", European Journal Of Medicinal Chemistry, 393 (2022), DOI: 10.1016/j.ejmech.2022.114105
- James S. Bell, Sally Hayes, Charles Whitford, Juan Sanchez-Weatherby, Olga Shebanova, Nick J. Terrill, Thomas Sorensen, Ahmed Elsheikh, Keith M. Meek, "Tropocollagen springs allow collagen fibrils to stretch elastically", Acta Biomaterialia, 8 (2022), DOI: 10.1016/j.actbio.2022.01.041
- Sitthivut Charoensutthivarakul, Sherine E. Thomas, Amy Curran, Karen P. Brown, Juan M. Belardinelli, Andrew J. Whitehouse, Marta Acebron-Garcia-De-Eulate, Jaspar Sangan, Subramanian G. Gramani, Mary Jackson, Vitor Mendes, R. Andres Floto, Tom L. Blundell, Anthony G. Coyne, Chris Abell, "Development of inhibitors of SAICAR synthetase (PurC) from Mycobacterium abscessus using a fragment-based approach", Acs Infectious Diseases (2022), DOI: 10.1021/acsinfecdis.1c00432
- Emil Johansson, Rémi Caraballo, Georg Zocher, Nitesh Mistry, Niklas Arnberg, Thilo Stehle, Mikael Elofsson, "Exploring divalent conjugates of 5-N-acetyl-neuraminic acid as inhibitors of coxsackievirus A24 variant (CVA24v) transduction", Rsc Advances, 12, 2319 - 2331 (2022), DOI: 10.1039/D1RA08968D
- Manuel González-Cuesta, Peter Sidhu, Roger A. Ashmus, Alexandra Males, Cameron Proceviat, Zarina Madden, Jason C. Rogalski, Jil A. Busmann, Leonard J. Foster, José M. García Fernández, Gideon J. Davies, Carmen Ortiz Mellet, David J. Vocadlo, "Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications", Journal Of The American Chemical Society (2022), DOI: 10.1021/jacs.1c10504
- Marta Acebron-Garcia-De-Eulate, Joan Mayol-Llinàs, Matthew T. O. Holland, So Yeon Kim, Karen P. Brown, Chiara Marchetti, Jeannine Hess, Ornella Di Pietro, Vitor Mendes, Chris Abell, R. Andres Floto, Anthony G. Coyne, Tom L. Blundell, "Discovery of novel inhibitors of uridine diphosphate-n-acetylenolpyruvylglucosamine reductase (MurB) from Pseudomonas aeruginosa, an opportunistic infectious agent causing death in cystic fibrosis patients", Journal Of Medicinal Chemistry, 48 (2022), DOI: 10.1021/acs.jmedchem.1c01684
- David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul V. Fish, Fredrik Svensson, "Virtual screening directly identifies new fragment-sized inhibitors of carboxylesterase notum with nanomolar activity", Journal Of Medicinal Chemistry, 65, 562 - 578 (2022), DOI: 10.1021/acs.jmedchem.1c01735
- [Thesis] John D. Clarke, "Structural analysis of the cattle antibody repertoire" (2022)
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
Diamond Light Source Ltd
Diamond House
Harwell Science & Innovation Campus
Didcot
Oxfordshire
OX11 0DE
Copyright © Diamond Light Source. Diamond Light Source® and the Diamond logo are registered trademarks of Diamond Light Source Ltd
Registered in England and Wales at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom. Company number: 4375679. VAT number: 287 461 957. Economic Operators Registration and Identification (EORI) number: GB287461957003.