Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I03 Contact
Beamline Phone Number:
+44 (0) 1235 778707
Acting Principal Beamline Scientist:
Dave Hall
Tel: +44 (0) 1235 778926
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I03 MX
Status: Operational
Beamsize: 90 µm x 20 µm
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
These publications are based on data gathered on beamline I03. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
86 items found for 2012 [total: 2353]
Functional insights from the crystal structure of the N-Terminal domain of the prototypical toll receptor Structure, Dec 2012 DOI: 10.1016/j.str.2012.11.003
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity Journal Of Medicinal Chemistry, 56 (3) Dec 2012 DOI: 10.1021/jm301495v
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure of a pestivirus envelope glycoprotein E2 clarifies its role in cell entry Cell Reports, Dec 2012 DOI: 10.1016/j.celrep.2012.12.001
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structures of MBOgg1 in complex with two abasic DNA ligands Journal Of Structural Biology, 181 (3) Dec 2012 DOI: 10.1016/j.jsb.2012.12.003
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin Proceedings Of The National Academy Of Sciences, 109 (52) Dec 2012 DOI: 10.1073/pnas.1218841110
Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint) Biochemical Journal, 448 Dec 2012 DOI: 10.1042/BJ20121448
Architecture of the major component of the type III secretion system export apparatus Nature Structural & Molecular Biology, 20 (1) Dec 2012 DOI: 10.1038/nsmb.2452
Journal Paper I03-Macromolecular Crystallography
Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex Proceedings Of The National Academy Of Sciences, Dec 2012 DOI: 10.1073/pnas.1214735109
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement Blood, 121 (7) Dec 2012 DOI: 10.1182/blood-2012-06-437202
Journal Paper I03-Macromolecular Crystallography
Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition Plos One, 7 (12) Dec 2012 DOI: 10.1371/journal.pone.0053339
Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster Febs Journal, 279 (24) Dec 2012 DOI: 10.1111/febs.12038
Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase Acs Chemical Biology, 8 (1) Dec 2012 DOI: 10.1021/cb300471n
The Discovery of new cyanobactins from Cyanothece PCC 7425 defines a new signature for processing of patellamides Chembiochem, 13 (18) Dec 2012 DOI: 10.1002/cbic.201200661
Journal Paper I03-Macromolecular Crystallography
Structural and functional characterization of the kindlin-1 pleckstrin homology domain Journal Of Biological Chemistry, 287 (52) Dec 2012 DOI: 10.1074/jbc.M112.422089
Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa Acs Chemical Biology, 8 (2) Nov 2012 DOI: 10.1021/cb300426u
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
The basis for carbapenem hydrolysis by class A β-lactamases: a combined investigation using crystallography and simulations Journal Of The American Chemical Society, 134 (44) Nov 2012 DOI: 10.1021/ja304460j
Comparative dynamics of NMDA- and AMPA-glutamate receptor N-terminal domains Structure, 20 (11) Nov 2012 DOI: 10.1016/j.str.2012.08.012
In situ beamline analysis and correction of active optics Journal Of Synchrotron Radiation, 19 (6) Nov 2012 DOI: 10.1107/S090904951203662X
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I15-Extreme Conditions I19-Small Molecule Single Crystal Diffraction I20-Scanning-X-ray spectroscopy (XAS/XES) I22-Small angle scattering & Diffraction
An improved racemase/acylase biotransformation for the preparation of enantiomerically pure amino acids Journal Of The American Chemical Society, 134 (47) Nov 2012 DOI: 10.1021/ja305438y
Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia Journal Of Medicinal Chemistry, Oct 2012 DOI: 10.1021/jm300952s
Production and crystallization of the C-propeptide trimer from human procollagen III Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (10) Oct 2012 DOI: 10.1107/S1744309112035294
Superstructure of the centromeric complex of TubZRC plasmid partitioning systems Proceedings Of The National Academy Of Sciences, 109 (41) Oct 2012 DOI: 10.1073/pnas.1210899109
Journal Paper I03-Macromolecular Crystallography
Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis Proceedings Of The National Academy Of Sciences, 109 (42) Oct 2012 DOI: 10.1073/pnas.1206563109
Crystal structure of human CDC7 kinase in complex with its activator DBF4 Nature Structural & Molecular Biology, 19 (11) Oct 2012 DOI: 10.1038/nsmb.2404
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
The structure of the ternary Eg5-ADP-ispinesib complex Acta Crystallographica Section D Biological Crystallography, 68 (10) Oct 2012 DOI: 10.1107/S0907444912027965
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex Nature Structural & Molecular Biology, 19 (12) Oct 2012 DOI: 10.1038/nsmb.2416
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Design and synthesis of inhibitors of Plasmodium falciparumN-myristoyltransferase, a promising target for antimalarial drug discovery Journal Of Medicinal Chemistry, 55 (20) Oct 2012 DOI: 10.1021/jm301160h
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis Plos Pathogens, 8 (9) Oct 2012 DOI: 10.1371/journal.ppat.1002914
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting Journal Of Biological Chemistry, 287 (44) Oct 2012 DOI: 10.1074/jbc.M112.386409
ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes Proceedings Of The National Academy Of Sciences, 109 (43) Oct 2012 DOI: 10.1073/pnas.1206839109
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing Nature Communications, 3 Oct 2012 DOI: 10.1038/ncomms2077
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
The reaction coordinate of a bacterial GH47 α-mannosidase: a combined quantum mechanical and structural approach Angewandte Chemie International Edition, 51 (44) Oct 2012 DOI: 10.1002/anie.201205338
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Serine is a natural ligand and allosteric activator of pyruvate kinase M2 Nature, 491 (7424) Oct 2012 DOI: 10.1038/nature11540
Journal Paper I03-Macromolecular Crystallography
Structural basis of fibrillar collagen trimerization and related genetic disorders Nature Structural & Molecular Biology, 19 (10) Sept 2012 DOI: 10.1038/nsmb.2389
Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121 Angewandte Chemie International Edition, 51 (37) Sept 2012 DOI: 10.1002/anie.201202544
Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein-ligand crystallography Bioorganic & Medicinal Chemistry, Sept 2012 DOI: 10.1016/j.bmc.2012.09.024
Crystallization and preliminary crystallographic analysis of the NheA component of the Nhe toxin from Bacillus cereus Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (9) Sept 2012 DOI: 10.1107/S1744309112030813
Journal Paper I03-Macromolecular Crystallography
The crystal structure of the lipid II-degrading bacteriocin syringacin M suggests unexpected evolutionary relationships between colicin M-like bacteriocins Journal Of Biological Chemistry, Sept 2012 DOI: 10.1074/jbc.M112.400150
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function Nature Chemical Biology, Sept 2012 DOI: 10.1038/nchembio.1081
Journal Paper I03-Macromolecular Crystallography
A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase Biochemical Journal, Sept 2012 DOI: 10.1042/BJ20121014
Journal Paper I03-Macromolecular Crystallography
Interaction of pentraxins and collectins with lipopolysaccharide ligands Aug 2012
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural basis for ASPP2 recognition by the tumor suppressor p73 Journal Of Molecular Biology, Aug 2012 DOI: 10.1016/j.jmb.2012.08.005
Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer Open Biology, 2 Aug 2012 DOI: 10.1098/rsob.120071
Structure of a bacteriophytochrome and light-stimulated protomer swapping with a gene repressor Structure, 20 (8) Aug 2012 DOI: 10.1016/j.str.2012.06.002
Journal Paper I03-Macromolecular Crystallography
Crystallization and preliminary X-ray analysis of the receiver domain of a putative response regulator, BPSL0128, from Burkholderia pseudomallei Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (8) Aug 2012 DOI: 10.1107/S1744309112025791
Journal Paper I03-Macromolecular Crystallography
Dimerization properties of the RpBphP2 chromophore-binding domain crystallized by homologue-directed mutagenesis Acta Crystallographica Section D Biological Crystallography, 68 (8) Aug 2012 DOI: 10.1107/S0907444912020537
Journal Paper I03-Macromolecular Crystallography
TCR/pMHC optimized protein crystallization screen Journal Of Immunological Methods, 382 Aug 2012 DOI: 10.1016/j.jim.2012.06.007
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Small-Molecule Inhibition of BRDT for Male Contraception Cell, 150 (4) Aug 2012 DOI: 10.1016/j.cell.2012.06.045
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (7) Jul 2012 DOI: 10.1107/S1744309112023597
Crystal structure and substrate specificity of the thermophilic serine:pyruvate aminotransferase from Acta Crystallographica Section D Biological Crystallography, 68 (7) Jul 2012 DOI: 10.1107/S0907444912011274
Journal Paper I03-Macromolecular Crystallography
Alternating access mechanism in the POT family of oligopeptide transporters The Embo Journal, 31 (16) June 2012 DOI: 10.1038/emboj.2012.157
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family Bmc Structural Biology, 12 June 2012 DOI: 10.1186/1472-6807-12-14
Selective deactivation of serum IgG: a general strategy for the enhancement of monoclonal antibody receptor interactions Journal Of Molecular Biology, 420 June 2012 DOI: 10.1016/j.jmb.2012.04.002
Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases Journal Of Medicinal Chemistry, 55 (12) June 2012 DOI: 10.1021/jm300157n
Crystallization and preliminary crystallographic analysis of the major capsid proteins VP16 and VP17 of bacteriophage P23-77 Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (5) May 2012 DOI: 10.1107/S1744309112010330
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
3'-Processing and strand transfer catalysed by retroviral integrase in crystallo The Embo Journal, 31 (13) May 2012 DOI: 10.1038/emboj.2012.118
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53 Journal Of The American Chemical Society, 134 (15) Apr 2012 DOI: 10.1021/ja301056a
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Tetartohedral twinning could happen to you too Acta Crystallographica Section D Biological Crystallography, 68 (4) Apr 2012 DOI: 10.1107/S0907444912006737
Structural basis of the intracellular sorting of the SNARE VAMP7 by the AP3 adaptor complex Developmental Cell, 22 (5) Apr 2012 DOI: 10.1016/j.devcel.2012.01.018
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
FolX from Pseudomonas aeruginosa is octameric in both crystal and solution Febs Letters, 586 (8) Mar 2012 DOI: 10.1016/j.febslet.2012.03.031
Insights into dynein motor domain function from a 3.3-Å crystal structure Nature Structural & Molecular Biology, Mar 2012 DOI: 10.1038/nsmb.2272
Targeting the von Hippel–Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction Journal Of The American Chemical Society, 134 (10) Mar 2012 DOI: 10.1021/ja209924v
Structural analysis of the C-Terminal Region (modules 18-20) of complement regulator factor H (FH) Plos One, 7 (2) Mar 2012 DOI: 10.1371/journal.pone.0032187
Structural and functional characterization of the product of disease-related factor H gene conversion Biochemistry, 51 (9) Mar 2012 DOI: 10.1021/bi201689j
Gating mechanisms for biological electron transfer: Integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase Febs Letters, 586 (5) Mar 2012 DOI: 10.1016/j.febslet.2011.07.003
Noncatalytic ions direct the RNA-dependent RNA polymerase of bacterial double-stranded RNA virus ϕ6 from de novo initiation to elongation Journal Of Virology, 86 (5) Mar 2012 DOI: 10.1128/JVI.05168-11
Journal Paper I03-Macromolecular Crystallography
Crystal structure of a Trypanosoma brucei metacaspase Proceedings Of The National Academy Of Sciences, 109 Mar 2012 DOI: 10.1073/pnas.1200885109
Histone recognition and large-scale structural analysis of the human bromodomain family Cell, 149 (1) Mar 2012 DOI: 10.1016/j.cell.2012.02.013
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Diverse HIV viruses are targeted by a conformationally dynamic antiviral Nature Structural & Molecular Biology, 19 (4) Mar 2012 DOI: 10.1038/nsmb.2253
Journal Paper I03-Macromolecular Crystallography
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors Nature Biotechnology, 30 (3) Feb 2012 DOI: 10.1038/nbt.2121
Journal Paper I03-Macromolecular Crystallography
Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds Plos One, 7 (2) Feb 2012 DOI: 10.1371/journal.pone.0032217
An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid Nature Communications, 3 Feb 2012 DOI: 10.1038/ncomms1680
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex Nature Structural & Molecular Biology, 19 (3) Feb 2012 DOI: 10.1038/nsmb.2235
Specialized peptidoglycan hydrolases sculpt the intra-bacterial niche of predatory Bdellovibrio and increase population fitness Plos Pathogens, 8 (2) Feb 2012 DOI: 10.1371/journal.ppat.1002524
Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export Nucleic Acids Research, 40 (10) Feb 2012 DOI: 10.1093/nar/gks059
Synergy of peptide and sugar in O-GlcNAcase substrate recognition Chemistry & Biology, 19 (2) Feb 2012 DOI: 10.1016/j.chembiol.2012.01.011
Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid Proceedings Of The National Academy Of Sciences, 109 (6) Feb 2012 DOI: 10.1073/pnas.1117275109
The structural characterization of a prophage-encoded extracellular DNase from Streptococcus pyogenes Nucleic Acids Research, 40 (2) Jan 2012 DOI: 10.1093/nar/gkr789
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation Nucleic Acids Research, Jan 2012 DOI: 10.1093/nar/gks023
Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes Nature Immunology, Jan 2012 DOI: 10.1038/ni.2206
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl Nature Structural & Molecular Biology, 19 (2) Jan 2012 DOI: 10.1038/nsmb.2231
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structural and mechanistic insight into N-glycan processing by endo- -mannosidase Proceedings Of The National Academy Of Sciences, Jan 2012 DOI: 10.1073/pnas.1111482109
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates Journal Of Biological Chemistry, 287 (3) Jan 2012 DOI: 10.1074/jbc.M111.313015
A distal pocket leu residue inhibits the binding of O2 and NO at the distal heme site of cytochrome c′ Journal Of The American Chemical Society, 134 (3) Jan 2012 DOI: 10.1021/ja209770p
Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands Journal Of The American Chemical Society, 134 (5) Jan 2012 DOI: 10.1021/ja2102423
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structure and mechanism of the CMR complex for CRISPR-mediated antiviral immunity Molecular Cell, Jan 2012 DOI: 10.1016/j.molcel.2011.12.013
Journal Paper I03-Macromolecular Crystallography
- Monique Gangloff, Christopher J. Arnot, Miranda Lewis, Nicholas J. Gay, "Functional insights from the crystal structure of the N-Terminal domain of the prototypical toll receptor", Structure (2012), DOI: 10.1016/j.str.2012.11.003
- Alison J. Hole, Sonja Baumli, Hao Shao, Shenhua Shi, Chris Pepper, Peter M. Fischer, Shudong Wang, Jane A. Endicott, Martin E. Noble, "Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity", Journal Of Medicinal Chemistry, 56 (3) (2012), DOI: 10.1021/jm301495v
- Kamel El Omari, Oleg Iourin, Karl Harlos, Jonathan Grimes, Dave Stuart, "Structure of a pestivirus envelope glycoprotein E2 clarifies its role in cell entry", Cell Reports (2012), DOI: 10.1016/j.celrep.2012.12.001
- Hongjun Yu, Mingzhang Yang, Xian-En Zhang, Lijun Bi, Tao Jiang, "Crystal structures of MBOgg1 in complex with two abasic DNA ligands", Journal Of Structural Biology, 181 (3) (2012), DOI: 10.1016/j.jsb.2012.12.003
- Y. P. Lin, X. Xiong, S. A. Wharton, S. R. Martin, P. J. Coombs, S. G. Vachieri, E. Christodoulou, P Walker, J. Liu, J. J. Skehel, S Gamblin, A. J. Hay, R. S. Daniels, J. W. Mccauley, "Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin", Proceedings Of The National Academy Of Sciences, 109 (52), 21474 - 21479 (2012), DOI: 10.1073/pnas.1218841110
- Philippe Thebault, Dimitri Y. Chirgadze, Zhen Dou, Tom Blundell, Sabine Elowe, Victor Bolanos-Garcia, "Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)", Biochemical Journal, 448, 321 - 328 (2012), DOI: 10.1042/BJ20121448
- Patrizia Abrusci, Marta Vergara-Irigaray, Steven Johnson, Morgan D. Beeby, David R. Hendrixson, Pietro Roversi, Miriam E. Friede, Janet E. Deane, Grant J. Jensen, Christoph M. Tang, Susan Lea, "Architecture of the major component of the type III secretion system export apparatus", Nature Structural & Molecular Biology, 20 (1), 99 - 104 (2012), DOI: 10.1038/nsmb.2452
- Matheshwaran Saravanan, Jochen Wuerges, Daniel Bose, Elizabeth A. Mccormack, Nicola J. Cook, Xiaodong Zhang, Dale B. Wigley, "Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex", Proceedings Of The National Academy Of Sciences (2012), DOI: 10.1073/pnas.1214735109
- J. Ekeruche-Makinde, J. J. Miles, H. A. Van Den Berg, A. Skowera, D. K. Cole, G. Dolton, A. J. A. Schauenburg, M. P. Tan, J. M. Pentier, S. Llewellyn-Lacey, K. M. Miles, A. M. Bulek, M. Clement, T. Williams, A. Trimby, M. Bailey, P. Rizkallah, J. Rossjohn, M. Peakman, D. A. Price, S. R. Burrows, A. K. Sewell, L. Wooldridge, "Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement", Blood, 121 (7), 1112-1123 (2012), DOI: 10.1182/blood-2012-06-437202
- Rhodri M. L. Morgan, Laura C. Hernández-Ramírez, Giampaolo Trivellin, Lihong Zhou, S. Mark Roe, Márta Korbonits, Chrisostomos Prodromou, "Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition", Plos One, 7 (12) (2012), DOI: 10.1371/journal.pone.0053339
- Akif Mohd, Geoffrey Masuyer, Richard Bingham, Edward Sturrock, R. Elwyn Isaac, Ravi Acharya, "Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster", Febs Journal, 279 (24), 4525 - 4534 (2012), DOI: 10.1111/febs.12038
- Mathieu Métifiot, Kasthuraiah Maddali, Barry C. Johnson, Stephen Hare, Steven J. Smith, Xue Zhi Zhao, Christophe Marchand, Terrence R. Burke, Stephen H. Hughes, Peter Cherepanov, Yves Pommier, "Activities, crystal structures, and molecular dynamics of dihydro-1H-isoindole derivatives, inhibitors of HIV-1 integrase", Acs Chemical Biology, 8 (1) (2012), DOI: 10.1021/cb300471n
- Wael E. Houssen, Jesko Koehnke, David Zollman, Jeremie Vendome, Andrea Raab, Margaret C. M. Smith, James H. Naismith, Marcel Jaspars, "The Discovery of new cyanobactins from Cyanothece PCC 7425 defines a new signature for processing of patellamides", Chembiochem, 13 (18), 2683 - 2689 (2012), DOI: 10.1002/cbic.201200661
- L.a. Yates, C. N. Lumb, N. N. Brahme, R. Zalyte, L. E. Bird, L. De Colibus, R. J. Owens, D. A. Calderwood, M. S. P. Sansom, R. J. C. Gilbert, "Structural and functional characterization of the kindlin-1 pleckstrin homology domain", Journal Of Biological Chemistry, 287 (52), 43246 - 43261 (2012), DOI: 10.1074/jbc.M112.422089
- Magnus Alphey, Lisa Pirrie, Leah S. Torrie, Wassila Abdelli Boulkeroua, Mary Gardiner, Aurijit Sarkar, Marko Maringer, Wulf Oehlmann, Ruth Brenk, Michael S. Scherman, Michael Mcneil, Martin Rejzek, Robert A. Field, Mahavir Singh, David Gray, Nicholas J. Westwood, James H. Naismith, "Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa", Acs Chemical Biology, 8 (2) (2012), DOI: 10.1021/cb300426u
- Fatima Fonseca, Ewa Chudyk, Marc W. Van Der Kamp, António Correia, Adrian J. Mulholland, James Spencer, "The basis for carbapenem hydrolysis by class A β-lactamases: a combined investigation using crystallography and simulations", Journal Of The American Chemical Society, 134 (44), 18275 - 18285 (2012), DOI: 10.1021/ja304460j
- Anindita Dutta, Indira h. Shrivastava, Madhav Sukumaran, Ingo H. Greger, Ivet Bahar, "Comparative dynamics of NMDA- and AMPA-glutamate receptor N-terminal domains", Structure, 20 (11), 1-12 (2012), DOI: 10.1016/j.str.2012.08.012
- John Sutter, Simon Alcock, Kawal Sawhney, "In situ beamline analysis and correction of active optics", Journal Of Synchrotron Radiation, 19 (6), 960 - 968 (2012), DOI: 10.1107/S090904951203662X
- Scott Baxter, Sylvain Royer, Gideon Grogan, Fraser Brown, Karen E. Holt-Tiffin, Ian N. Taylor, Ian G. Fotheringham, Dominic J. Campopiano, "An improved racemase/acylase biotransformation for the preparation of enantiomerically pure amino acids", Journal Of The American Chemical Society, 134 (47), 19310 - 19313 (2012), DOI: 10.1021/ja305438y
- Richard Bayliss, Vassilios Bavetsias, Julian Blagg, Simon Crumpler, Chongbo Sun, Sian Avery, Butrus Atrash, Amir Faisal, Andrew S. Moore, Magda Kosmopoulou, Nathan Brown, Peter W. Sheldrake, Katherine Bush, Alan Henley, Gary Box, Melanie Valenti, Alexis De Haven Brandon , Florence I. Raynaud, Paul Workman, Suzanne A. Eccles, Spiros Linardopoulos, "Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia", Journal Of Medicinal Chemistry (2012), DOI: 10.1021/jm300952s
- J.-M. Bourhis, N. Mariano, Y. Zhao, T. S. Walter, K. El Omari, F. Delolme, C. Moali, D. J. S. Hulmes, N. Aghajari, "Production and crystallization of the C-propeptide trimer from human procollagen III", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (10), 1209 - 1213 (2012), DOI: 10.1107/S1744309112035294
- Christopher H. S. Aylett, Jan Lowe, "Superstructure of the centromeric complex of TubZRC plasmid partitioning systems", Proceedings Of The National Academy Of Sciences, 109 (41), 16522 - 16527 (2012), DOI: 10.1073/pnas.1210899109
- Duo Lu, Jan Silhan, James T. Macdonald, Elisabeth P. Carpenter, Kirsten Jensen, Christoph M. Tang, Geoff S. Baldwin, Paul S. Freemont, "Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis", Proceedings Of The National Academy Of Sciences, 109 (42), 16852 - 16857 (2012), DOI: 10.1073/pnas.1206563109
- Siobhan Hughes, Frédéric Elustondo, Andrea Di Fonzo, Frédéric G. Leroux, Ai C. Wong, Ambrosius P. Snijders, Stephen J. Matthews, Peter Cherepanov, "Crystal structure of human CDC7 kinase in complex with its activator DBF4", Nature Structural & Molecular Biology, 19 (11), 1101 - 1107 (2012), DOI: 10.1038/nsmb.2404
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