Filamin C dimerisation is regulated by HSPB7 Zihao Wang, Guodong Cao, Miranda P. Collier, Xingyu Qiu, Sophie Broadway-Stringer, Dominik Šaman, Jediael Z. Y. Ng, Navoneel Sen, Amar J. Azad, Charlotte Hooper, Johannes Zimmermann, Michael A. Mcdonough, Jurgen Brem, Patrick Rabe, Haigang Song, T. Reid Alderson, Christopher J. Schofield, Jani R. Bolla, Kristina Djinovic-Carugo, Dieter O. Fürst, Bettina Warscheid, Matteo T. Degiacomi, Timothy M. Allison, Georg K. A. Hochberg, Carol V. Robinson, Katja Gehmlich, Justin L. P. Benesch
Nature Communications, 16 May 2025 DOI: 10.1038/s41467-025-58889-x Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance Matthew J. Beech, Edmond C. Toma, Helen G. Smith, Maria M. Trush, Jit H. J. Ang, Mei Y. Wong, Chung H. J. Wong, Hafiz S. Ali, Zakia Butt, Viha Goel, Fernanda Duarte, Alistair J. M. Farley, Timothy R. Walsh, Christopher J. Schofield
Chemical Science, 5 May 2025 DOI: 10.1039/D5SC00964B Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy Zhixiang Chen, Harshil Dhruv, Xuqing Zhang, Rohan Kalyan Rej, Longchuan Bai, Donna Mceachern, Paul Kirchhoff, Rakesh Nagilla, Larry J. Jolivette, Cory T. Rice, Peter Orth, Corey O. Strickland, E. Scott Priestley, Helai P. Mohammad, Meilin Wang, Bo Wen, Duxin Sun, Zhihua Sui, Shaomeng Wang
Nature Communications, 16 May 2025 DOI: 10.1038/s41467-025-58431-z Efficient and selective energy transfer photoenzymes powered by visible light Rebecca Crawshaw, Ross Smithson, Johannes Hofer, Florence J. Hardy, George W. Roberts, Jonathan S. Trimble, Anna R. Kohn, Colin W. Levy, Deborah A. Drost, Christian Merten, Derren J. Heyes, Richard Obexer, Thorsten Bach, Anthony P. Green
Nature Chemistry, 357 May 2025 DOI: 10.1038/s41557-025-01820-0 Silaproline-bearing nirmatrelvir derivatives are potent inhibitors of the SARS-CoV-2 main protease highlighting the value of silicon-derivatives in structure-activity-relationship studies Dóra Laczi, Sofia Schönbauer Huamán, Taylah Andrews-Clark, Stephen M. Laidlaw, Eidarus Salah, Leo Dumjahn, Petra Lukacik, Hani Choudhry, Martin A. Walsh, Miles W. Carroll, Christopher J. Schofield, Lennart Brewitz
European Journal Of Medicinal Chemistry, 374 Apr 2025 DOI: 10.1016/j.ejmech.2025.117603 Observation of the assembly of the nascent mineral core at the nucleation site of human mitochondrial ferritin Justin M. Bradley, Zinnia Bugg, Geoffrey R. Moore, Andrew m. Hemmings, Nick E. Le Brun
Journal Of The American Chemical Society, Apr 2025 DOI: 10.1021/jacs.5c01337 Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access Design of novel mercapto-3-phenylpropanoyl dipeptides as dual angiotensin-converting enzyme C–domain-selective/neprilysin inhibitors Gyles E. Cozier, Lauren B. Coulson, Charles J. Eyermann, Gregory S. Basarab, Sylva L. Schwager, Kelly Chibale, Edward D. Sturrock, K. Ravi Acharya
Journal Of Medicinal Chemistry, Apr 2025 DOI: 10.1021/acs.jmedchem.5c00329 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access Structure-guided design of ISOX-DUAL-based degraders targeting BRD4 and CBP/EP300: A case of degrader collapse Anthony K. Edmonds, Dimitrios-Ilias Balourdas, Graham P. Marsh, Robert Felix, Bradley Brasher, Jeff Cooper, Cari Graber-Feesl, Madhu Kollareddy, Karim Malik, Helen Stewart, Timothy J. T. Chevassut, Ella Lineham, Simon Morley, Oleg Fedorov, James Bennett, Mohan B. Rajasekaran, Samuel Ojeda, Drew A. Harrison, Christopher J. Ott, Andreas C. Joerger, Hannah J. Maple, John Spencer
Journal Of Medicinal Chemistry, Apr 2025 DOI: 10.1021/acs.jmedchem.5c00395 Understanding the endo- and exo-mechanisms involved in the enzymatic hydrolysis of levan and inulin polymers Jaime Ricardo Porras-Domínguez, Abimael Cruz-Migoni, Stephen B. Carr, Maria Elena Rodríguez-Alegría, Agustín López-Munguía, Wim Van Den Ende
Journal Of Agricultural And Food Chemistry, Apr 2025 DOI: 10.1021/acs.jafc.5c00187 Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine Kalvis Brangulis, Jill Malfetano, Ashley L. Marcinkiewicz, Alan Wang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Dagnija Tupina, Inara Akopjana, Maria-Elena Bottazzi, Utpal Pal, Ching-Lin Hsieh, Wen-Hsiang Chen, Yi-Pin Lin
Nature Communications, 16 Apr 2025 DOI: 10.1038/s41467-025-58182-x An engineered biocatalyst for enantioselective hydrazone reduction Anthony P. Green, Amy E. Hutton, Fei Zhao, Elizabeth Ho, Jack Domenech, Vanessa Harawa, Murray J. B. Brown, Gideon Grogan, Phillip D. Clayman, Nicholas J. Turner
Angewandte Chemie International Edition, Apr 2025 DOI: 10.1002/anie.202424350 Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles Michael E. Østergaard, Michele Carrer, Brooke A. Anderson, Megan Afetian, Mohsen a. Bakooshli, Jinro A. Santos, Stephanie K. Klein, Juliana Capitanio, Graeme c. Freestone, Michael Tanowitz, Rodrigo Galindo-Murillo, Hans J. Gaus, Chrissa a. Dwyer, Michaela Jackson, Paymaan Jafar-Nejad, Frank Rigo, Punit P. Seth, Katherine U Gaynor, Steven J. Stanway, Liudvikas Urbonas, Megan A. St. Denis, Simone Pellegrino, Gustavo A. Bezerra, Michael Rigby, Ellen Mcgowans, Katerine Van Rietschoten, Paul Beswick, Liuhong Chen, Michael J. Skynner, Eric E. Swayze
Nucleic Acids Research, 53 Apr 2025 DOI: 10.1093/nar/gkaf270 Divergent dimerization mechanisms and conserved DNA-binding function in PFam12 proteins of Borrelia burgdorferi Kalvis Brangulis, Dagnija Tupina, Everita Elina Sinicina, Diana Zelencova-Gopejenko, Inara Akopjana, Janis Bogans, Kaspars Tars
Scientific Reports, 15 Apr 2025 DOI: 10.1038/s41598-025-93944-z Structural insights into the dynamics of water in SOD1 catalysis and drug interactions Ilkin Yapici, Arda Gorkem Tokur, Belgin Sever, Halilibrahim Ciftci, Ayse Nazli Basak, Hasan Demirci
International Journal Of Molecular Sciences, 26 Apr 2025 DOI: 10.3390/ijms26094228 UFC1 reveals the multifactorial and plastic nature of oxyanion holes in E2 conjugating enzymes Manoj Kumar, Sayanika Banerjee, Einav Cohen-Kfir, Marissa Basia Mitelberg, Suryakant Tiwari, Michail N. Isupov, Moshe Dessau, Reuven Wiener
Nature Communications, 16 Apr 2025 DOI: 10.1038/s41467-025-58826-y A DNA-gated molecular guard controls bacterial Hailong anti-phage defence Joel M. J. Tan, Sarah Melamed, Joshua C. Cofsky, Deepsing Syangtan, Samuel J. Hobbs, Josefina Del Marmol, Marco Jost, Andrew C. Kruse, Rotem Sorek, Philip J. Kranzusch
Nature, Apr 2025 DOI: 10.1038/s41586-025-09058-z Structure and catalytic mechanism of methylisocitrate lyase, a potential drug target against Coxiella burnetii William S. Stuart, Christopher H. Jenkins, Philip M. Ireland, Michail N. Isupov, Isobel H. Norville, Nicholas J. Harmer
Journal Of Biological Chemistry, 42 Apr 2025 DOI: 10.1016/j.jbc.2025.108517 Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Derivatives of the clinically used HIF prolyl hydroxylase inhibitor desidustat are efficient inhibitors of human γ-butyrobetaine hydroxylase Thomas P. Corner, Anthony Tumber, Eidarus Salah, Mohammadparsa Jabbary, Yu Nakashima, Lara I. Schnaubelt, Shyam Basak, Faisal M. Alshref, Lennart Brewitz, Christopher J. Schofield
Journal Of Medicinal Chemistry, 28 Apr 2025 DOI: 10.1021/acs.jmedchem.5c00586 Expansion of the diversity of dispersin scaffolds Alexandra Males, Olga V. Moroz, Elena Blagova, Astrid Munch, Gustav H. Hansen, Annette H. Johansen, Lars H. Østergaard, Dorotea R. Segura, Alexander Eddenden, Anne V. Due, Martin Gudmand, Jesper Salomon, Sebastian R. Sørensen, Joao Paulo L. Franco Cairo, Mark Nitz, Roland A. Pache, Rebecca M. Vejborg, Sandeep Bhosale, David J. Vocadlo, Gideon J. Davies, Keith S. Wilson
Acta Crystallographica Section D Structural Biology, 81 Mar 2025 DOI: 10.1107/S205979832500110X Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access Crystal structure of ferric recombinant horseradish peroxidase Mst Luthfun Nesa, Suman K. Mandal, Christine Toelzer, Diana Humer, Peter C. E. Moody, Imre Berger, Oliver Spadiut, Emma L. Raven
Jbic Journal Of Biological Inorganic Chemistry, 2 Mar 2025 DOI: 10.1007/s00775-025-02103-2 Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore Shawn C. Massoni, Nicola J. Evans, Ingo Hantke, Colleen Fenton, James H. Torpey, Katherine M. Collins, Ewelina M. Krysztofinska, Janina H. Muench, Arjun Thapaliya, Santiago Martínez-Lumbreras, Sé Hart Ferrell, Celia Slater, Xinyue Wang, Ruth Fekade, Sandra Obwar, Siyu Yin, Alishba Vazquez, Christopher B. Prior, Kürşad Turgay, Rivka L. Isaacson, Amy H. Camp
Genes & Development, Mar 2025 DOI: 10.1101/gad.352498.124 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) Chemical targeting of prolyl-tRNA synthetase stalls ovarian development and kills malaria vectors Ritu Goswami, Yogavel Manickam, Jyoti Chhibber Goel, Swati Gupta, B. M. Shrinivasa, Amit Sharma
The Journal Of Infectious Diseases, Mar 2025 DOI: 10.1093/infdis/jiaf095 Discovery of TNG462: a highly potent and selective MTA-cooperative PRMT5 inhibitor to target cancers with MTAP deletion Kevin M. Cottrell, Kimberly J. Briggs, Alice Tsai, Matthew R. Tonini, Douglas A. Whittington, Shanzhong Gong, Colin Liang, Patrick Mccarren, Minjie Zhang, Wenhai Zhang, Alan Huang, John P. Maxwell
Journal Of Medicinal Chemistry, Mar 2025 DOI: 10.1021/acs.jmedchem.4c03067 Phylogenetic analysis and structural studies of heteromeric acetyl-CoA carboxylase from the oleaginous Amazonian microalgae Ankistrodesmus sp.: Insights into the BC and BCCP subunits Andry Mercedes Mavila, Jhon Antoni Vargas, Eloy Condori, Erick Giancarlo Suclupe Farro, Adriano Alves Furtado, Josué Manuel López, Silvia Lucila Gonzalez, Humberto D’muniz Pereira, Jorge Luis Marapara, Roger Ruiz Paredes, Marianela Cobos, Juan C. Castro, Richard Charles Garratt, Diego Antonio Leonardo
Journal Of Structural Biology, 630 Mar 2025 DOI: 10.1016/j.jsb.2025.108200 Reversible small molecule multivariant ras inhibitors display tunable affinity for the active and inactive forms of Ras Charles W. Parry, Francesca Pellicano, Alexander W. Schuettelkopf, Kim S. Beyer, Justin Bower, Amy Bryson, Kenneth Cameron, Nichole M. Cerutti, Jonathan P. Clark, Stuart C. Davidson, Keneth Davies, Martin J. Drysdale, Jeffrey Engelman, Anna Estevan-Barber, Andrea Gohlke, Christopher H. Gray, Daniel A. Guthy, Min Hong, Alana Hopkins, Luke D. Hutchinson, Jennifer Konczal, Michel Maira, Duncan Mcarthur, Mokdad Mezna, Heather Mckinnon, Ridvan Nepravishta, Nils Ostermann, Camila C. Pasquali, Katie Pollock, Angelo Pugliese, Nicholas Rooney, Niko Schmiedeberg, Paul Shaw, Camilo Velez-Vega, Christopher West, Ryan West, Frederic Zecri, John B. Taylor
Journal Of Medicinal Chemistry, 49 Mar 2025 DOI: 10.1021/acs.jmedchem.4c02929 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Discovery of mono-ADP ribosylating toxins with high structural homology to Pseudomonas exotoxin A Geoffrey Masuyer, Alistair Taverner, Julia Mackay, Ana Rita Lima Marques, Yuye Wang, Tom Hunter, Keyi Liu, Randall J. Mrsny
Communications Biology, 8 Mar 2025 DOI: 10.1038/s42003-025-07845-y Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure Yeojin Kim, Stefan Knapp, Andreas Kramer
Acta Crystallographica Section F Structural Biology Communications, 81 Mar 2025 DOI: 10.1107/S2053230X25000913 Pharmacological targeting of BMAL1 modulates circadian and immune pathways Hua Pu, Laura C. Bailey, Ludwig G. Bauer, Maria Voronkov, Matthew Baxter, Kilian V. M. Huber, Sepideh Khorasanizadeh, David Ray, Fraydoon Rastinejad
Nature Chemical Biology, 418 Mar 2025 DOI: 10.1038/s41589-025-01863-x RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS Avinash V. Dharmadhikari, Maria Alba Abad, Sheraz Khan, Reza Maroofian, Tristan T. Sands, Farid Ullah, Itaru Samejima, Yanwen Shen, Martin A. Wear, Kiara E. Moore, Elena Kondakova, Natalia Mitina, Theres Schaub, Grace K. Lee, Christine H. Umandap, Sara M. Berger, Alejandro D. Iglesias, Bernt Popp, Rami Abou Jamra, Heinz Gabriel, Stefan Rentas, Alyssa L. Rippert, Christopher Gray, Kosuke Izumi, Laura K. Conlin, Daniel C. Koboldt, Theresa Mihalic Mosher, Scott E. Hickey, Dara V. F. Albert, Haley Norwood, Amy Feldman Lewanda, Hongzheng Dai, Pengfei Liu, Tadahiro Mitani, Dana Marafi, Hatice Koçak Eker, Davut Pehlivan, Jennifer E. Posey, Natalie C. Lippa, Natalie Vena, Erin L. Heinzen, David B. Goldstein, Cyril Mignot, Jean-Madeleine De Sainte Agathe, Nouriya Abbas Al-Sannaa, Mina Zamani, Saeid Sadeghian, Reza Azizimalamiri, Tahere Seifia, Maha S. Zaki, Ghada M. H. Abdel-Salam, Mohamed S. Abdel-Hamid, Lama Alabdi, Fowzan Sami Alkuraya, Heba Dawoud, Aya Lofty, Peter Bauer, Giovanni Zifarelli, Erum Afzal, Faisal Zafar, Stephanie Efthymiou, Daniel Gossett, Meghan C. Towne, Raey Yeneabat, Belen Perez-Duenas, Ana Cazurro-Gutierrez, Edgard Verdura, Veronica Cantarin-Extremera, Ana Do Vale Marques, Aleksandra Helwak, David Tollervey, Sandeep N. Wontakal, Vimla S. Aggarwal, Jill A. Rosenfeld, Victor Tarabykin, Shinya Ohta, James R. Lupski, Henry Houlden, William C. Earnshaw, Erica E. Davis, A. Arockia Jeyaprakash, Jun Liao
Nature Communications, 16 Feb 2025 DOI: 10.1038/s41467-025-56876-w Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy Joseph A Newman, Angeline E. Gavard, Nergis Imprachim, Hazel Aitkenhead, Hadley E. Sheppard, Robert Te Poele, Paul A. Clarke, Mohammad Anwar Hossain, Louisa Temme, Hans J. Oh, Carrow I. Wells, Zachary W. Davis-Gilbert, Paul Workman, Opher Gileadi, David H. Drewry
Nature Communications, 16 Feb 2025 DOI: 10.1038/s41467-025-56213-1 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access Sulfoglycolysis sustains Eubacterium rectale in low-fiber diets Mahima Sharma, Nicholas Pudlo, Michael A. Järvå, Arashdeep Kaur, Alan John, Laura Burchill, James P. Lingford, Ruwan Epa, Palika Abayakoon, Nichollas E. Scott, Johan P. Turkenburg, Gideon J. Davies, Eric C. Martens, Ethan D. Goddard-Borger, Spencer J. Williams
Journal Of Biological Chemistry, 473 Feb 2025 DOI: 10.1016/j.jbc.2025.108320 Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access Bespoke activity-based probes reveal that the Pseudomonas aeruginosa endoglycosidase, PslG, is an endo-β-glucanase Gijs Ruijgrok, Wendy A. Offen, Isabelle B. Pickles, Deepa Raju, Thanasis Patsos, Casper De Boer, Tim Ofman, Joep Rompa, Daan Van Oord, Eleanor J. Dodson, Alexander Beekers, Thijs Voskuilen, Michela Ferrari, Liang Wu, Antonius P. A. Janssen, Jeroen D. C. Codée, P. Lynne Howell, Gideon J. Davies, Herman S. Overkleeft
Journal Of The American Chemical Society, Feb 2025 DOI: 10.1021/jacs.4c16806 Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel Mélanie Loiodice, Elodie Drula, Zak Mciver, Svetlana Antonyuk, Arnaud Basle, Marcelo Lima, Edwin A. Yates, Dominic P. Byrne, Jamie Coughlan, Andrew Leech, Shahram Mesdaghi, Daniel J. Rigden, Sophie Drouillard, William Helbert, Bernard Henrissat, Nicolas Terrapon, Gareth S. A. Wright, Marie Couturier, Alan Cartmell
Proceedings Of The National Academy Of Sciences, 122 Feb 2025 DOI: 10.1073/pnas.2421623122 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Virtual fragment screening for DNA repair inhibitors in vast chemical space Andreas Luttens, Duc Duy Vo, Emma R. Scaletti, Elisée Wiita, Ingrid Almlöf, Olov Wallner, Jonathan Davies, Sara Kosenina, Liuzhen Meng, Maeve Long, Oliver Mortusewicz, Geoffrey Masuyer, Flavio Ballante, Maurice Michel, Evert Homan, Martin Scobie, Christina Kalderén, Ulrika Warpman Berglund, Andrii V. Tarnovskiy, Dmytro S. Radchenko, Yurii S. Moroz, Jan Kihlberg, Pål Stenmark, Thomas Helleday, Jens Carlsson
Nature Communications, 16 Feb 2025 DOI: 10.1038/s41467-025-56893-9 Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Binding‐site purification of actives (B‐SPA) enables efficient large‐scale progression of fragment hits by combining multi‐step array synthesis with HT crystallography Harold Grosjean, Anthony Aimon, Storm Hassell-Hart, Warren Thompson, Lizbe Koekemoer, James Bennett, Anthony Bradley, Cameron Anderson, Conor Wild, William J. Bradshaw, Edward A. Fitzgerald, Tobias Krojer, Oleg Fedorov, Philip C. Biggin, John Spencer, Frank Von Delft
Angewandte Chemie International Edition, Feb 2025 DOI: 10.1002/anie.202424373 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) The 2-methylcitrate cycle and the glyoxylate shunt in Pseudomonas aeruginosa are linked through enzymatic redundancy Andre J. Wijaya, Stephen K. Dolan, Michael Kohlstedt, Lars Gläser, Paul Brear, Stephen Geddis, Christoph Wittmann, David R. Spring, Martin Welch
Journal Of Biological Chemistry, 6 Feb 2025 DOI: 10.1016/j.jbc.2025.108355 Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability Josh Mcquail, Miroslav Krepl, Kai Katsuya-Gaviria, Aline Tabib-Salazar, Lynn Burchell, Thorsten Bischler, Tom Gräfenhan, Paul Brear, Jiří Šponer, Ben F. Luisi, Sivaramesh Wigneshweraraj
Nucleic Acids Research, 53 Feb 2025 DOI: 10.1093/nar/gkaf019 Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access Understanding the molecular mechanism of fumonisin esterases by kinetic and structural studies Dániel J. Incze, Zsófia Molnár, Gergely N. Nagy, Ibolya Leveles, Beáta G. Vértessy, László Poppe, Zsófia Bata
Food Chemistry, 50 Jan 2025 DOI: 10.1016/j.foodchem.2025.143110 Phenotype-led identification of IL-10 upregulators in human CD4+ T-cells and elucidation of their pharmacology as highly selective CDK8/CDK19 inhibitors Simon Nicolle, Mike Barker, John Barrett, Matthew Campbell, Justyna Wojno-Picon, Stephen J. Atkinson, Helen Aylott, Hripsimee Kessedjian, Yanan He, Cassie Messenger, Emma Roberts, Claus Spitzfaden, Joelle Le, Nico Zinn, Thilo Werner, Birgit Dümpelfeld, Marcus Bantscheff, Don O. Somers, Heather Reid, Kevin Thang, Thomas Gobbetti, Huw D. Lewis
Journal Of Medicinal Chemistry, 2390 Jan 2025 DOI: 10.1021/acs.jmedchem.4c02630 Structure, kinetics, and mechanism of Pseudomonas putida sulfoquinovose dehydrogenase, the first enzyme in the sulfoglycolytic Entner-Doudoroff pathway Laura Burchill, Mahima Sharma, Niccolay Madiedo Soler, Ethan D. Goddard-Borger, Gideon J. Davies, Spencer J. Williams
Biochemical Journal, 482 Jan 2025 DOI: 10.1042/BCJ20240605 Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan Ter Meulen, Dhruv K. Sethi
Communications Biology, 8 Jan 2025 DOI: 10.1038/s42003-024-07410-z Molecular basis of human angiotensin‐1 converting enzyme inhibition by a series of diprolyl‐derived compounds Kyle S. Gregory, Gyles E. Cozier, Stephen Fienberg, Kelly Chibale, Edward D. Sturrock, K. Ravi Acharya
The Febs Journal, 389 Jan 2025 DOI: 10.1111/febs.17384 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access Tearing down bacterial membranes with new antibiotics Diamond Light Source
Jan 2025 Science Highlight I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Phase Ib study of PRT543, an oral protein arginine methyltransferase 5 (PRMT5) inhibitor, in patients with advanced splicing factor-mutant myeloid malignancies Jan Philipp Bewersdorf, Xiaoli Mi, Bin Lu, Andrew Kuykendall, David Sallman, Manish Patel, Don Stevens, Alexander Philipovskiy, Grerk Sutamtewagul, Lucia Masarova, Gina Keiffer, Amit Verma, Neha Bhagwat, Min Wang, Andrew Moore, Joseph Rager, Diane Heiser, Sunhee Ro, Wan-Jen Hong, Omar Abdel-Wahab, Eytan M. Stein
Leukemia, 138 Jan 2025 DOI: 10.1038/s41375-025-02515-8 KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid Thomas C. Mclean, Francisco Balaguer-Pérez, Joshua Chandanani, Christopher M. Thomas, Clara Aicart-Ramos, Sophia Burick, Paul Dominic B. Olinares, Giulia Gobbato, Julia E. A. Mundy, Brian T. Chait, David M. Lawson, Seth A. Darst, Elizabeth A. Campbell, Fernando Moreno-Herrero, Tung Le
Nature Microbiology, 20 Jan 2025 DOI: 10.1038/s41564-024-01915-3 Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide Audrey Le Bas, Bradley R. Clarke, Tanisha Teelucksingh, Micah Lee, Kamel El Omari, Andrew M. Giltrap, Stephen A. Mcmahon, Hui Liu, John H. Beale, Vitaliy Mykhaylyk, Ramona Duman, Neil G. Paterson, Philip N. Ward, Peter J. Harrison, Miriam Weckener, Els Pardon, Jan Steyaert, Huanting Liu, Andrew Quigley, Benjamin G. Davis, Armin Wagner, Chris Whitfield, James H. Naismith
Open Biology, 15 Jan 2025 DOI: 10.1098/rsob.240310 Journal Paper I03-Macromolecular Crystallography I23-Long wavelength MX I24-Microfocus Macromolecular Crystallography Krios II-Titan Krios II at Diamond open access Engineered enzymes for enantioselective nucleophilic aromatic substitutions Thomas M. Lister, George W. Roberts, Euan J. Hossack, Fei Zhao, Ashleigh J. Burke, Linus O. Johannissen, Florence J. Hardy, Alexander A. V. Millman, David Leys, Igor Larrosa, Anthony P. Green
Nature, Jan 2025 DOI: 10.1038/s41586-025-08611-0