Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I03 Contact
Beamline Phone Number:
+44 (0) 1235 778707
Acting Principal Beamline Scientist:
Dave Hall
Tel: +44 (0) 1235 778926
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I03 MX
Status: Operational
Beamsize: 90 µm x 20 µm
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
These publications are based on data gathered on beamline I03. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
74 items found for 2026 [total: 2379]
Engineering a cytochrome P450 O-demethylase for the bioconversion of hardwood lignin Acs Synthetic Biology, 1 Jul 2026 DOI: 10.1021/acssynbio.6c00337
Journal Paper I03-Macromolecular Crystallography
Janus kinase 2 activation loop as a regulator of catalysis and trans-activation International Journal Of Biological Macromolecules, 409 Jul 2026 DOI: 10.1016/j.ijbiomac.2026.153276
A de novo CO2 reductase featuring a cysteine-ligated cobalt porphyrin cofactor Journal Of The American Chemical Society, Jul 2026 DOI: 10.1021/jacs.6c07615
How cryoEM has advanced our understanding of bacteriophages and bacteriocins targeting Clostridioides difficile Iucrj, 13 Jul 2026 DOI: 10.1107/S2052252526005105
Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features Ebiomedicine, 129 Jul 2026 DOI: 10.1016/j.ebiom.2026.106358
Probing the role of accessory domains in oxygen stability of [FeFe]-hydrogenases Journal Of The American Chemical Society, 6340 Jul 2026 DOI: 10.1021/jacs.6c05865
Functional role of a tethered domain as a naturally fused cognate partner is demonstrated in a three-domain copper nitrite reductase Iucrj, 13 Jul 2026 DOI: 10.1107/S2052252526004549
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural insights into multitargeting Mycobacterium tuberculosis Pkn kinases Microbiology Spectrum, 59 Jul 2026 DOI: 10.1128/spectrum.00049-26
Global identification of Chromobacterium violaceum T6SS effectors reveals an Rhs antibacterial toxin featuring FIX and ADP-ribosyltransferase domains Journal Of Biological Chemistry, 197 June 2026 DOI: 10.1016/j.jbc.2026.113216
Structural and functional mapping of protective human monoclonal antibodies against enterovirus A71 Science Advances, 12 June 2026 DOI: 10.1126/sciadv.aee8217
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure-based discovery of potent BCL-XL inhibitors through rescaffolding Journal Of Medicinal Chemistry, 60 June 2026 DOI: 10.1021/acs.jmedchem.6c00865
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
A chemoproteomic biotechnological toolkit for resolving xylanase specificity in decorated xylan Nature Communications, June 2026 DOI: 10.1038/s41467-026-74484-0
Variant-dependent pharmacological rescue of phenylalanine hydroxylase supports a precision therapeutic strategy for phenylketonuria Biomedicine & Pharmacotherapy, 199 June 2026 DOI: 10.1016/j.biopha.2026.119371
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure-guided optimization of novel inhibitors of Plasmodium lysyl-tRNA synthetase with multistage activity against malaria parasites Journal Of Medicinal Chemistry, 45 June 2026 DOI: 10.1021/acs.jmedchem.6c00823
Receptor-substrate competition for the TonB homolog FusB suggests a model for ferredoxin import Journal Of Biological Chemistry, 302 June 2026 DOI: 10.1016/j.jbc.2026.113121
Structure, characterisation and application of an unspecific peroxygenase from Daldinia childiae Rsc Chemical Biology, June 2026 DOI: 10.1039/D6CB00141F
Discovery of an orally available potent ER Aminopeptidase 1 (ERAP1) inhibitor that enhances antitumor responses and limits inflammatory autoimmunity in vivo Journal Of Medicinal Chemistry, June 2026 DOI: 10.1021/acs.jmedchem.6c00029
Journal Paper I03-Macromolecular Crystallography
Synthesis of novel serine β-lactamase inhibitors June 2026
Thesis I03-Macromolecular Crystallography
Structural architecture of a hybrid β-barrel assembly machinery BAM-TAM complex in Borrelia burgdorferi Journal Of Biological Chemistry, 35 June 2026 DOI: 10.1016/j.jbc.2026.113267
Structural basis for uracil removal from DNA by human SMUG1 Nature Communications, 17 June 2026 DOI: 10.1038/s41467-026-72937-0
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and biophysical analysis of the four CHRD domains of human chordin reveals a novel binding site for glycosaminoglycans Journal Of Biological Chemistry, 8 June 2026 DOI: 10.1016/j.jbc.2026.113248
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Targeted protein degradation of NUDT5 dissociates catalytic inhibition from protein loss in 6-thioguanine response Nature Communications, June 2026 DOI: 10.1038/s41467-026-74489-9
Two birds with one stone: An antibiotic hit blocking Staphylococcus aureus heme uptake with serendipitous hemoglobin left-shifting activity Iscience, 29 May 2026 DOI: 10.1016/j.isci.2026.115625
Optimization and in vivo characterization of a series of Cbl-b inactive-state inhibitors Acs Medicinal Chemistry Letters, May 2026 DOI: 10.1021/acsmedchemlett.6c00103
Journal Paper I03-Macromolecular Crystallography
Fluorogenic coupled assays reveal catalytic properties, inhibition constants and cellular location of mucin-active carbohydrate sulfatases Angewandte Chemie International Edition, 597 May 2026 DOI: 10.1002/anie.2991471
Rapid fragment screening by 19F steady-state free precession NMR Angewandte Chemie International Edition, 5 May 2026 DOI: 10.1002/anie.6891540
The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error Febs Open Bio, 35 May 2026 DOI: 10.1002/2211-5463.70268
Targeting a pleckstrin homology domain with a lysine-reactive covalent binder Journal Of Medicinal Chemistry, May 2026 DOI: 10.1021/acs.jmedchem.5c03818
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Development of water-trapping pyrrole-2-carboxylic acids as broad-spectrum metallo-β-lactamase inhibitors Journal Of Medicinal Chemistry, May 2026 DOI: 10.1021/acs.jmedchem.5c03534
Induced circular dichroism from the binding of achiral bivalent ligands to transthyretin Journal Of Molecular Recognition, 39 May 2026 DOI: 10.1002/jmr.70037
Journal Paper B23-Circular Dichroism I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Crystallise, poise, capture: a multimodal platform for correlated structural and spectroscopic characterisation of redox enzymes Jbic Journal Of Biological Inorganic Chemistry, 13 May 2026 DOI: 10.1007/s00775-026-02148-x
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Identification and validation of 3-cyano-quinoline ligands targeting integrin-linked kinase (ILK) Journal Of Medicinal Chemistry, May 2026 DOI: 10.1021/acs.jmedchem.5c03773
Structural basis of iron piracy by human gut Bacteroides Proceedings Of The National Academy Of Sciences, 123 May 2026 DOI: 10.1073/pnas.2528036123
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
ssRNA bacteriophage metagenomes reveal a diverse set of novel protein families Protein Science, 35 May 2026 DOI: 10.1002/pro.70582
Crystal structure of HERV-K envelope glycoprotein surface subunit Journal Of Virology, May 2026 DOI: 10.1128/jvi.00195-26
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Nicotine biosynthesis is completed by cryptic activating glucosylation Nature Communications, 17 May 2026 DOI: 10.1038/s41467-026-72705-0
Uridine cytidine kinases govern molnupiravir bioactivation and anti-SARS-CoV-2 activity Plos Pathogens, 22 May 2026 DOI: 10.1371/journal.ppat.1014225
Prothrombinase processivity is conferred by substrate allostery The Embo Journal, 630 Apr 2026 DOI: 10.1038/s44318-026-00782-4
Structure-based design of a novel covalent 4-(1-methylindol-3-yl)pyrimidin-2-amine series targeting FGFR2 resistance mutations Journal Of Medicinal Chemistry, 69 Apr 2026 DOI: 10.1021/acs.jmedchem.6c00514
Journal Paper I03-Macromolecular Crystallography
Pharmacological inhibition of PMS2 induces MMR deficiency and response to immune checkpoint blockade Cancer Discovery, Apr 2026 DOI: 10.1158/2159-8290.CD-26-0003
Template technology for biocrystallization Apr 2026 DOI: 10.26174/thesis.lboro.32048493
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography VMXm-Versatile Macromolecular Crystallography microfocus
Cattle antibodies identify a cross-serotype broadly neutralising foot-and-mouth disease virus epitope Npj Vaccines, 450 Apr 2026 DOI: 10.1038/s41541-026-01427-7
The Mycobacterium tuberculosis Rv0132c gene product Mtb-FGD2 can act as an F420-dependent glucose dehydrogenase Proteins: Structure, Function, And Bioinformatics, 124 Apr 2026 DOI: 10.1002/prot.70139
Structural and functional characterization of a hyperthermostable single‐stranded DNA ‐binding protein from a hot spring metagenome Protein Science, 35 Apr 2026 DOI: 10.1002/pro.70538
Journal Paper I03-Macromolecular Crystallography
Automated molecular design in BRADSHAW, applied to the optimization of ERAP1 inhibitors Journal Of Medicinal Chemistry, Apr 2026 DOI: 10.1021/acs.jmedchem.5c03071
The human TIMP-1 unbound structure provides a platform for fragment screening Acta Crystallographica Section D Structural Biology, 82 Apr 2026 DOI: 10.1107/S2059798326001749
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Discovery and characterization of novel 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthase from thermophilic (meta)genomes Catalysts, 16 Apr 2026 DOI: 10.3390/catal16040305
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence Biochemical Journal, Mar 2026 DOI: 10.1042/BCJ20260019
Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life Cell, 189 Mar 2026 DOI: 10.1016/j.cell.2026.01.008
Evolutionarily divergent DUF4465 domains have a common vitamin B12 ‐binding function Febs Open Bio, 369 Mar 2026 DOI: 10.1002/2211-5463.70231
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Design, optimization and characterization of a de novo gold hydroaminase Acs Catalysis, Mar 2026 DOI: 10.1021/acscatal.5c08100
Journal Paper I03-Macromolecular Crystallography
Crystallographic data for Pyrococcus furiosus dolichylphosphate mannose synthase suggest that the enzyme could flip its glycolipid product Scientific Reports, 16 Mar 2026 DOI: 10.1038/s41598-026-44343-5
Yeast display technology enables rapid discovery of low-nanomolar macrocyclic peptide inhibitors of human angiotensin-converting enzyme 2 Journal Of Medicinal Chemistry, 7 Mar 2026 DOI: 10.1021/acs.jmedchem.5c02876
Metal-dependent 2-keto-3,6-dideoxy-6-sulfo-gluconate (KDSG) aldolase: decoding the key C-C bond cleaving step in bacterial sulfoglycolysis Chemistry – A European Journal, 28 Mar 2026 DOI: 10.1002/chem.70857
Binding of 14-3-3 stabilises recombinant AMPKγ2-containing complexes Biochemical Journal, Mar 2026 DOI: 10.1042/BCJ20250342
Structural and functional validation of Pseudomonas savastanoi ethylene forming enzymes reveals flexibility in 2-oxoglutarate binding mode and conformation Chembiochem, 27 Mar 2026 DOI: 10.1002/cbic.202500702
An enzyme's metal preference evolves through redox modulation driven by the cofactor’s secondary coordination sphere Molecular Biology And Evolution, Feb 2026 DOI: 10.1093/molbev/msag040
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Nucleotide signals coordinate activation and inhibition of bacterial immunity Nature, 480 Feb 2026 DOI: 10.1038/s41586-026-10135-0
Journal Paper I03-Macromolecular Crystallography
Structure and characterisation of CMP-Kdn synthetase from the haptophyte microalgae Prymnesium parvum Rsc Chemical Biology, 14 Feb 2026 DOI: 10.1039/D5CB00285K
Phosphorylation of inner core heptose is a major determinant of bacterial surface lipopolysaccharide recognition by the innate immune protein hSP-D Journal Of Biological Chemistry, 164 Feb 2026 DOI: 10.1016/j.jbc.2026.111307
Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase Nature Communications, 30 Feb 2026 DOI: 10.1038/s41467-026-69425-w
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt Cell Death & Disease, 85 Feb 2026 DOI: 10.1038/s41419-026-08492-9
Disulfide bond mapping of follitropin delta, a recombinant follicle stimulating hormone (rFSH), by X-ray crystallography Pharmaceuticals, 19 Feb 2026 DOI: 10.3390/ph19030380
Fragment-based development of NSP14 exonuclease inhibitors confounded by batch-to-batch variability Acs Chemical Biology, Feb 2026 DOI: 10.1021/acschembio.5c00930
Structures of proteinase 3 and the CD177 receptor complex reveal a major autoantibody epitope Embo Reports, 161 Feb 2026 DOI: 10.1038/s44319-026-00716-5
Structure, function, and applications of two novel phage recombinases from extreme environments Nucleic Acids Research, 54 Feb 2026 DOI: 10.1093/nar/gkag069
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery Communications Biology, 9 Jan 2026 DOI: 10.1038/s42003-026-09584-0
Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery Proceedings Of The National Academy Of Sciences, 123 Jan 2026 DOI: 10.1073/pnas.2525941123
A hooker oxygenase archetype in polyketide biosynthesis challenging the Baeyer–Villiger monooxygenase paradigm Journal Of The American Chemical Society, Jan 2026 DOI: 10.1021/jacs.5c21759
Cell wall target fragment discovery using a low‐cost, minimal fragment library Febs Letters, 12 Jan 2026 DOI: 10.1002/1873-3468.70281
C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐ CoA lyase Febs Open Bio, 11 Jan 2026 DOI: 10.1002/2211-5463.70199
Discovery of SY-589, a highly potent and orally bioavailable Polθ helicase inhibitor for the treatment of HR-deficient tumors Journal Of Medicinal Chemistry, Jan 2026 DOI: 10.1021/acs.jmedchem.5c02689
Journal Paper I03-Macromolecular Crystallography
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors Nature Communications, 16 Jan 2026 DOI: 10.1038/s41467-026-68319-1
Modulation of the 14-3-3σ/C-RAF “auto” inhibited complex by molecular glues Journal Of The American Chemical Society, Jan 2026 DOI: 10.1021/jacs.5c12622
- Megan E. Wolf, Daniel J. Hinchen, Michael Zahn, John Mcgeehan, Lindsay D. Eltis, "Engineering a cytochrome P450 O-demethylase for the bioconversion of hardwood lignin", Acs Synthetic Biology, 1 (2026), DOI: 10.1021/acssynbio.6c00337
- Ya Miao, Vasyl V. Mykuliak, Stevan R. Hubbard, Olli Silvennoinen, Vesa Hytönen, Teemu Haikarainen, "Janus kinase 2 activation loop as a regulator of catalysis and trans-activation", International Journal Of Biological Macromolecules, 409 (2026), DOI: 10.1016/j.ijbiomac.2026.153276
- Emily J. Radley, Alessia C. Andrews, Indrek Kalvet, Yunling Deng, Elizabeth L. Bell, Colin W. Levy, Mary Ortmayer, Derren J. Heyes, Clare F. Megarity, Reyes Núñez-Franco, Amy E. Hutton, Yi Lu, David Baker, Anthony P. Green, "A de novo CO2 reductase featuring a cysteine-ligated cobalt porphyrin cofactor", Journal Of The American Chemical Society (2026), DOI: 10.1021/jacs.6c07615
- Per A. Bullough, Jason S. Wilson, Hannah L. Berry, Robert P. Fagan, "How cryoEM has advanced our understanding of bacteriophages and bacteriocins targeting Clostridioides difficile", Iucrj, 13, 324 - 342 (2026), DOI: 10.1107/S2052252526005105
- Elisa Peirano, Laura O'Regan, Philip Harrer, Ivana Dzinovic, Magda S. Chegkazi, Petra Havrankova, Theresa Brunet, Rossella Capolino, Claudia Cesario, Stefania Ferro, Eva Hammar, Russia Hà-Vinh Leuchter, Elisabetta Indelicato, Maureen Jacob, Lukas Kunc, Henri Margot, Oriano Marin, Maria Mazurkiewicz-Bełdzińska, Niccolò E. Mencacci, Antonio Novelli, Laura Orec, Michael Poschmann, Alexandra Sitzberger, Ugo Sorrentino, Melanie Spanjaard, Matias Wagner, Magdalena Krygier, Sylvia Boesch, Jan Necpal, Matej Skorvanek, Donald L. Gilbert, Robert Jech, Mark Dodding, Roberto A. Steiner, Michael Zech, "Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features", Ebiomedicine, 129 (2026), DOI: 10.1016/j.ebiom.2026.106358
- Abdulrahman Alogaidi, Stephen Carr, Lucy Hudson, Henry Lloyd-Laney, Alison Parkin, Ashley Love, Michael W. George, Anca Pordea, Simone Morra, "Probing the role of accessory domains in oxygen stability of [FeFe]-hydrogenases", Journal Of The American Chemical Society, 6340 (2026), DOI: 10.1021/jacs.6c05865
- Nopphon Petchyam, Allegra Mbouku, Robert R. Eady, S. Samar Hasnain, Svetlana V. Antonyuk, "Functional role of a tethered domain as a naturally fused cognate partner is demonstrated in a three-domain copper nitrite reductase", Iucrj, 13 (2026), DOI: 10.1107/S2052252526004549
- Angelika Pölläniemi, Ya Miao, Lotta Laitila, Hannaleena Piippo, Milka Hammarén, Mataleena Parikka, Teemu Haikarainen, "Structural insights into multitargeting Mycobacterium tuberculosis Pkn kinases", Microbiology Spectrum, 59 (2026), DOI: 10.1128/spectrum.00049-26
- Júlia A. Alves, Genady Pankov, Andrew M. Frey, Matthias Trost, Germán G. Sgro, Sarah J. Coulthurst, José F. Da Silva Neto, "Global identification of Chromobacterium violaceum T6SS effectors reveals an Rhs antibacterial toxin featuring FIX and ADP-ribosyltransferase domains", Journal Of Biological Chemistry, 197 (2026), DOI: 10.1016/j.jbc.2026.113216
- Daming Zhou, Abhay Kotecha, James T. Kelly, Peng-Nien Huang, Yi-Yin Chen, Thomas S. Walter, Helen M. E. Duyvesteyn, Raymond J. Owens, Shu-Yuan Ho, Tzou-Yien Lin, Elizabeth E. Fry, Jingshan Ren, Kuan-Ying A. Huang, David I. Stuart, "Structural and functional mapping of protective human monoclonal antibodies against enterovirus A71", Science Advances, 12 (2026), DOI: 10.1126/sciadv.aee8217
- Matyas Pal Timari, Attila Paczal, Andras Herner, Mark Molnar, Zoltan Madarasz, Miklos Nyerges, Simon T. Bedford, Teresa Brooks, James Davidson, Zoe Daniels, Mark Dodsworth, Pawel Dokurno, James B. Murray, Rachel Parsons, Emma Sanders, Julia Smith, Paul Webb, Neil Whitehead, Roderick E. Hubbard, Jérôme-Benoît Starck, Ana Leticia Maragno, Gaëtane Le Toumelin-Braizat, Laura Bresson, Francesca Rocchetti, Didier Demarles, Frédéric Colland, Olivier Geneste, Andras Kotschy, Tibor Novak, "Structure-based discovery of potent BCL-XL inhibitors through rescaffolding", Journal Of Medicinal Chemistry, 60 (2026), DOI: 10.1021/acs.jmedchem.6c00865
- Thamy L. R. Correa, Zirui Li, Olga Moroz, Isabelle B. Pickles, Andrey A. Lebedev, Saeed Akkad, Lianne I. Willems, Jeroen D. C. Codée, Herman S. Overkleeft, Gideon J. Davies, "A chemoproteomic biotechnological toolkit for resolving xylanase specificity in decorated xylan", Nature Communications (2026), DOI: 10.1038/s41467-026-74484-0
- María Conde-Giménez, Sandra Salillas, María Galiana-Cameo, Juan E. Martínez-Oliván, Alejandro Mahía, Manuel Ledesma, Juan José Galano-Frutos, Ritwik Maity, Adrián Velázquez-Campoy, María D. Díaz-De-Villegas, Ramon Hurtado-Guerrero, Javier Sancho, "Variant-dependent pharmacological rescue of phenylalanine hydroxylase supports a precision therapeutic strategy for phenylketonuria", Biomedicine & Pharmacotherapy, 199 (2026), DOI: 10.1016/j.biopha.2026.119371
- Barbara Forte, Fiona Bellany, Peter S. Campbell, Giulia Chemi, Alice Dawson, Mark Anderson, Yaw Aniweh, Anna Y. Burkhard, Anna Caroline Campos Aguiar, Alisje Churchyard, Caitlin A. Cooper, Amália Dos Santos Ferreira, Mufuliat Toyin Famodimu, Francis G. Fang, Xiao Hu, Tonnie Huijs, Delphine Baud, Chimed Jansen, María Belén Jiménez Díaz, Roger Bonnert, Susan Boyd, Benigno Crespo-Fernández, Branko Mitasev, Simone Montagna, Sachel Mok, Dinakaran Murugesan, Sunil K. Narwal, Neil R. Norcross, John Okombo, Heekuk Park, Caroline Peet, Dhelio B. Pereira, John M. Post, Janette Reader, Jennifer Riley, David A. Robinson, Raku Shinkyo, Frederick R. C. Simeons, Laura Simpson, Alasdair Smith, Dennis Smith, Josefine Striepen, Carolina B. G. Teles, Rianne Van Der Laak, Anne-Catrin Uhlemann, Amélie Vantaux, Caroline Wilson, Benoît Witkowski, Gavin Wood, Tomas Yeo, Fabio Zuccotto, Iñigo Angulo-Barturen, Jake Baum, Judith M. Bolscher, Rafael Victorio Carvalho Guido, Lyn-Marié Birkholtz, Michael J. Delves, Laurent Dembele, David A. Fidock, Francisco Javier Gamo, Dennis E. Kyle, Steven P. Maher, Jean Popovici, Chris Walpole, Fabian Gusovsky, Paul A. Willis, Kevin D. Read, Ian H. Gilbert, Beatriz Baragaña, "Structure-guided optimization of novel inhibitors of Plasmodium lysyl-tRNA synthetase with multistage activity against malaria parasites", Journal Of Medicinal Chemistry, 45 (2026), DOI: 10.1021/acs.jmedchem.6c00823
- Marta Wojnowska, Victor Flores, Tamas Yelland, Stuart R. Fisher, Agnieszka Bogucka, Katherine Stott, Daniel Walker, "Receptor-substrate competition for the TonB homolog FusB suggests a model for ferredoxin import", Journal Of Biological Chemistry, 302 (2026), DOI: 10.1016/j.jbc.2026.113121
- Alexander Mckenzie, Claudia Clark, Katy A. S. Cornish, Jiacheng Li, Jack Domenech, Benjamin Melling, Miles P. H. Ralston, Jared Cartwright, Nicholas P. Mulholland, William P. Unsworth, Gideon Grogan, "Structure, characterisation and application of an unspecific peroxygenase from Daldinia childiae", Rsc Chemical Biology (2026), DOI: 10.1039/D6CB00141F
- Christopher P. Tinworth, Justyna Wojno-Picon, Michael Adam, Stephan Gade, Ashley P. Hancock, David J. Hirst, Jonathan P. Hutchinson, Semra Kitchen, Despoina Koumantou, Jonathan Lea, Stephanie Lehmann, John Liddle, Richard Lonsdale, Margarete Neu, Leng Nickels, Alex Phillipou, James E. Rowedder, Paul Rowland, Jessica L. Schneck, Paul Scott-Stevens, Hester Sheehan, Michael Steidel, Chloe L. Tayler, Ioannis Temponeras, Kevin Thang, David F. Tough, Giovanni Vitulli, Ian D. Wall, Robert J. Young, Nico Zinn, Simon Peace, Efstratios Stratikos, "Discovery of an orally available potent ER Aminopeptidase 1 (ERAP1) inhibitor that enhances antitumor responses and limits inflammatory autoimmunity in vivo", Journal Of Medicinal Chemistry (2026), DOI: 10.1021/acs.jmedchem.6c00029
- [Thesis] Justin Young Ho, "Synthesis of novel serine β-lactamase inhibitors" (2026)
- Kalvis Brangulis, "Structural architecture of a hybrid β-barrel assembly machinery BAM-TAM complex in Borrelia burgdorferi", Journal Of Biological Chemistry, 35 (2026), DOI: 10.1016/j.jbc.2026.113267
- Julian M. Ludäscher, Emma Scaletti Hutchinson, Guillem Vila-Julià, Ann-Sofie Jemth, Saher Shahid, Elisee Wiita, Israel Cabeza De Vaca, Szymon Pach, Lukas Gajdos, Swati Aggarwal, Ellen Walse, Oliver Mortusewicz, Thomas Helleday, Jens Carlsson, Pal Stenmark, "Structural basis for uracil removal from DNA by human SMUG1", Nature Communications, 17 (2026), DOI: 10.1038/s41467-026-72937-0
- Matthew Snee, Holly L. Birchenough, Mark H. Becker, Jonathan F. Popplewell, Hilary L. Ashe, Clair Baldock, "Structural and biophysical analysis of the four CHRD domains of human chordin reveals a novel binding site for glycosaminoglycans", Journal Of Biological Chemistry, 8 (2026), DOI: 10.1016/j.jbc.2026.113248
- Anne-Sophie M. C. Marques, Ludwig G. Bauer, Tuan-Anh Nguyen, Alejandro Gonzalez Orta, Jan-Lennart Venne, Carol Cheng, Esra Balikci, Yusi Liu, Barr Tivon, Alena Kroupova, Alessio Ciulli, Nir London, Stefan Kubicek, Kilian V. M. Huber, "Targeted protein degradation of NUDT5 dissociates catalytic inhibition from protein loss in 6-thioguanine response", Nature Communications (2026), DOI: 10.1038/s41467-026-74489-9
- Sarah Hijazi, Francesco Marchesani, Marialaura Marchetti, Valeria Buoli Comani, Paul Brear, Barbara Campanini, Luca Ronda, Serena Faggiano, Eleonora Gianquinto, Somayeh Asgharpour Hassankiade, Barbara Rolando, Francesca Spyrakis, Carlotta Compari, Loretta Lazzarato, Omar De Bei, Emanuela Frangipani, Stefano Bettati, "Two birds with one stone: An antibiotic hit blocking Staphylococcus aureus heme uptake with serendipitous hemoglobin left-shifting activity", Iscience, 29 (2026), DOI: 10.1016/j.isci.2026.115625
- Michael J. Lambrecht, Jun Liang, Peter Man-Un Ung, Malcolm P. Huestis, Bing-Yan Zhu, Lisa M. Barton, Georgette M. Castanedo, Jason R. Zbieg, Robin Larouche-Gauthier, Araz Jakalian, Jean-Philippe Leclerc, Arun Yadav, Pouyan Haghshenas, Samuel Aubert-Nicol, Hossein Ismaili, Liang Zhao, Mélissa Leblanc, Jian Wang, Shouliang Wang, Qiuyue Wang, Thomas Garner, Sophia Tan, Madeleine Prangley, Fabio Broccatelli, Jodie Pang, Jeremy Murray, Christine Yu, Peter Hsu, Sascha Rutz, Satoko Kakiuchi-Kiyota, Isabel Ishizuka, Dennis H. Leung, Ponien Kou, Linda Bao, Xiaojing Wang, "Optimization and in vivo characterization of a series of Cbl-b inactive-state inhibitors", Acs Medicinal Chemistry Letters (2026), DOI: 10.1021/acsmedchemlett.6c00103
- Charles W. E. Tomlinson, Madouc D. Bergers, David N. Bolam, Ana S. Luis, Alan Cartmell, Zachary Armstrong, "Fluorogenic coupled assays reveal catalytic properties, inhibition constants and cellular location of mucin-active carbohydrate sulfatases", Angewandte Chemie International Edition, 597 (2026), DOI: 10.1002/anie.2991471
- Laura Ruduša, Sintija Ozola, Kostiantyn P. Melnykov, Yaroslav I. Filatov, Serhiy V. Ryabukhin, Raitis Bobrovs, Dmytro M. Volochnyuk, Kristaps Jaudzems, Rihards Aleksis, "Rapid fragment screening by 19F steady-state free precession NMR", Angewandte Chemie International Edition, 5 (2026), DOI: 10.1002/anie.6891540
- Kalvis Brangulis, "The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error", Febs Open Bio, 35 (2026), DOI: 10.1002/2211-5463.70268
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