Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I03 Contact
Beamline Phone Number:
+44 (0) 1235 778707
Acting Principal Beamline Scientist:
Dave Hall
Tel: +44 (0) 1235 778926
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I03 MX
Status: Operational
Beamsize: 90 µm x 20 µm
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
These publications are based on data gathered on beamline I03. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
50 items found for 2026 [total: 2353]
Variant-dependent pharmacological rescue of phenylalanine hydroxylase supports a precision therapeutic strategy for phenylketonuria Biomedicine & Pharmacotherapy, 199 June 2026 DOI: 10.1016/j.biopha.2026.119371
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
ssRNA bacteriophage metagenomes reveal a diverse set of novel protein families Protein Science, 35 May 2026 DOI: 10.1002/pro.70582
Two birds with one stone: An antibiotic hit blocking Staphylococcus aureus heme uptake with serendipitous hemoglobin left-shifting activity Iscience, 29 May 2026 DOI: 10.1016/j.isci.2026.115625
Crystallise, poise, capture: a multimodal platform for correlated structural and spectroscopic characterisation of redox enzymes Jbic Journal Of Biological Inorganic Chemistry, 13 May 2026 DOI: 10.1007/s00775-026-02148-x
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Fluorogenic coupled assays reveal catalytic properties, inhibition constants and cellular location of mucin-active carbohydrate sulfatases Angewandte Chemie International Edition, 597 May 2026 DOI: 10.1002/anie.2991471
Crystal structure of HERV-K envelope glycoprotein surface subunit Journal Of Virology, May 2026 DOI: 10.1128/jvi.00195-26
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Induced circular dichroism from the binding of achiral bivalent ligands to transthyretin Journal Of Molecular Recognition, 39 May 2026 DOI: 10.1002/jmr.70037
Journal Paper B23-Circular Dichroism I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Development of water-trapping pyrrole-2-carboxylic acids as broad-spectrum metallo-β-lactamase inhibitors Journal Of Medicinal Chemistry, May 2026 DOI: 10.1021/acs.jmedchem.5c03534
Optimization and in vivo characterization of a series of Cbl-b inactive-state inhibitors Acs Medicinal Chemistry Letters, May 2026 DOI: 10.1021/acsmedchemlett.6c00103
Journal Paper I03-Macromolecular Crystallography
Rapid fragment screening by 19F steady-state free precession NMR Angewandte Chemie International Edition, 5 May 2026 DOI: 10.1002/anie.6891540
Nicotine biosynthesis is completed by cryptic activating glucosylation Nature Communications, 17 May 2026 DOI: 10.1038/s41467-026-72705-0
The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error Febs Open Bio, 35 May 2026 DOI: 10.1002/2211-5463.70268
Targeting a pleckstrin homology domain with a lysine-reactive covalent binder Journal Of Medicinal Chemistry, May 2026 DOI: 10.1021/acs.jmedchem.5c03818
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Uridine cytidine kinases govern molnupiravir bioactivation and anti-SARS-CoV-2 activity Plos Pathogens, 22 May 2026 DOI: 10.1371/journal.ppat.1014225
Template technology for biocrystallization Apr 2026 DOI: 10.26174/thesis.lboro.32048493
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography VMXm-Versatile Macromolecular Crystallography microfocus
The Mycobacterium tuberculosis Rv0132c gene product Mtb-FGD2 can act as an F420-dependent glucose dehydrogenase Proteins: Structure, Function, And Bioinformatics, 124 Apr 2026 DOI: 10.1002/prot.70139
Structure-based design of a novel covalent 4-(1-methylindol-3-yl)pyrimidin-2-amine series targeting FGFR2 resistance mutations Journal Of Medicinal Chemistry, 69 Apr 2026 DOI: 10.1021/acs.jmedchem.6c00514
Journal Paper I03-Macromolecular Crystallography
Automated molecular design in BRADSHAW, applied to the optimization of ERAP1 inhibitors Journal Of Medicinal Chemistry, Apr 2026 DOI: 10.1021/acs.jmedchem.5c03071
Cattle antibodies identify a cross-serotype broadly neutralising foot-and-mouth disease virus epitope Npj Vaccines, 450 Apr 2026 DOI: 10.1038/s41541-026-01427-7
Prothrombinase processivity is conferred by substrate allostery The Embo Journal, 630 Apr 2026 DOI: 10.1038/s44318-026-00782-4
Structural and functional characterization of a hyperthermostable single‐stranded DNA ‐binding protein from a hot spring metagenome Protein Science, 35 Apr 2026 DOI: 10.1002/pro.70538
Journal Paper I03-Macromolecular Crystallography
The human TIMP-1 unbound structure provides a platform for fragment screening Acta Crystallographica Section D Structural Biology, 82 Apr 2026 DOI: 10.1107/S2059798326001749
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Discovery and characterization of novel 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthase from thermophilic (meta)genomes Catalysts, 16 Apr 2026 DOI: 10.3390/catal16040305
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life Cell, 189 Mar 2026 DOI: 10.1016/j.cell.2026.01.008
The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence Biochemical Journal, Mar 2026 DOI: 10.1042/BCJ20260019
Evolutionarily divergent DUF4465 domains have a common vitamin B12 ‐binding function Febs Open Bio, 369 Mar 2026 DOI: 10.1002/2211-5463.70231
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Design, optimization and characterization of a de novo gold hydroaminase Acs Catalysis, Mar 2026 DOI: 10.1021/acscatal.5c08100
Journal Paper I03-Macromolecular Crystallography
Structural and functional validation of Pseudomonas savastanoi ethylene forming enzymes reveals flexibility in 2-oxoglutarate binding mode and conformation Chembiochem, 27 Mar 2026 DOI: 10.1002/cbic.202500702
Crystallographic data for Pyrococcus furiosus dolichylphosphate mannose synthase suggest that the enzyme could flip its glycolipid product Scientific Reports, 16 Mar 2026 DOI: 10.1038/s41598-026-44343-5
Metal-dependent 2-keto-3,6-dideoxy-6-sulfo-gluconate (KDSG) aldolase: decoding the key C-C bond cleaving step in bacterial sulfoglycolysis Chemistry – A European Journal, 28 Mar 2026 DOI: 10.1002/chem.70857
Yeast display technology enables rapid discovery of low-nanomolar macrocyclic peptide inhibitors of human angiotensin-converting enzyme 2 Journal Of Medicinal Chemistry, 7 Mar 2026 DOI: 10.1021/acs.jmedchem.5c02876
Binding of 14-3-3 stabilises recombinant AMPKγ2-containing complexes Biochemical Journal, Mar 2026 DOI: 10.1042/BCJ20250342
Journal Paper I03-Macromolecular Crystallography
Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase Nature Communications, 30 Feb 2026 DOI: 10.1038/s41467-026-69425-w
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structures of proteinase 3 and the CD177 receptor complex reveal a major autoantibody epitope Embo Reports, 161 Feb 2026 DOI: 10.1038/s44319-026-00716-5
Nucleotide signals coordinate activation and inhibition of bacterial immunity Nature, 480 Feb 2026 DOI: 10.1038/s41586-026-10135-0
Journal Paper I03-Macromolecular Crystallography
Phosphorylation of inner core heptose is a major determinant of bacterial surface lipopolysaccharide recognition by the innate immune protein hSP-D Journal Of Biological Chemistry, 164 Feb 2026 DOI: 10.1016/j.jbc.2026.111307
Disulfide bond mapping of follitropin delta, a recombinant follicle stimulating hormone (rFSH), by X-ray crystallography Pharmaceuticals, 19 Feb 2026 DOI: 10.3390/ph19030380
Structure, function, and applications of two novel phage recombinases from extreme environments Nucleic Acids Research, 54 Feb 2026 DOI: 10.1093/nar/gkag069
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
An enzyme's metal preference evolves through redox modulation driven by the cofactor’s secondary coordination sphere Molecular Biology And Evolution, Feb 2026 DOI: 10.1093/molbev/msag040
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Fragment-based development of NSP14 exonuclease inhibitors confounded by batch-to-batch variability Acs Chemical Biology, Feb 2026 DOI: 10.1021/acschembio.5c00930
Structure and characterisation of CMP-Kdn synthetase from the haptophyte microalgae Prymnesium parvum Rsc Chemical Biology, 14 Feb 2026 DOI: 10.1039/D5CB00285K
Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt Cell Death & Disease, 85 Feb 2026 DOI: 10.1038/s41419-026-08492-9
Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery Communications Biology, 9 Jan 2026 DOI: 10.1038/s42003-026-09584-0
Cell wall target fragment discovery using a low‐cost, minimal fragment library Febs Letters, 12 Jan 2026 DOI: 10.1002/1873-3468.70281
Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery Proceedings Of The National Academy Of Sciences, 123 Jan 2026 DOI: 10.1073/pnas.2525941123
Modulation of the 14-3-3σ/C-RAF “auto” inhibited complex by molecular glues Journal Of The American Chemical Society, Jan 2026 DOI: 10.1021/jacs.5c12622
Discovery of SY-589, a highly potent and orally bioavailable Polθ helicase inhibitor for the treatment of HR-deficient tumors Journal Of Medicinal Chemistry, Jan 2026 DOI: 10.1021/acs.jmedchem.5c02689
Journal Paper I03-Macromolecular Crystallography
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors Nature Communications, 16 Jan 2026 DOI: 10.1038/s41467-026-68319-1
A hooker oxygenase archetype in polyketide biosynthesis challenging the Baeyer–Villiger monooxygenase paradigm Journal Of The American Chemical Society, Jan 2026 DOI: 10.1021/jacs.5c21759
C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐ CoA lyase Febs Open Bio, 11 Jan 2026 DOI: 10.1002/2211-5463.70199
- María Conde-Giménez, Sandra Salillas, María Galiana-Cameo, Juan E. Martínez-Oliván, Alejandro Mahía, Manuel Ledesma, Juan José Galano-Frutos, Ritwik Maity, Adrián Velázquez-Campoy, María D. Díaz-De-Villegas, Ramon Hurtado-Guerrero, Javier Sancho, "Variant-dependent pharmacological rescue of phenylalanine hydroxylase supports a precision therapeutic strategy for phenylketonuria", Biomedicine & Pharmacotherapy, 199 (2026), DOI: 10.1016/j.biopha.2026.119371
- Jānis Rūmnieks, Ieva Baltā, Mihails Šišovs, Kaspars Tārs, "ssRNA bacteriophage metagenomes reveal a diverse set of novel protein families", Protein Science, 35 (2026), DOI: 10.1002/pro.70582
- Sarah Hijazi, Francesco Marchesani, Marialaura Marchetti, Valeria Buoli Comani, Paul Brear, Barbara Campanini, Luca Ronda, Serena Faggiano, Eleonora Gianquinto, Somayeh Asgharpour Hassankiade, Barbara Rolando, Francesca Spyrakis, Carlotta Compari, Loretta Lazzarato, Omar De Bei, Emanuela Frangipani, Stefano Bettati, "Two birds with one stone: An antibiotic hit blocking Staphylococcus aureus heme uptake with serendipitous hemoglobin left-shifting activity", Iscience, 29 (2026), DOI: 10.1016/j.isci.2026.115625
- Shoba Laxmi, Sofia Jaho, William K. Myers, Kylie A. Vincent, Stephen B. Carr, "Crystallise, poise, capture: a multimodal platform for correlated structural and spectroscopic characterisation of redox enzymes", Jbic Journal Of Biological Inorganic Chemistry, 13 (2026), DOI: 10.1007/s00775-026-02148-x
- Charles W. E. Tomlinson, Madouc D. Bergers, David N. Bolam, Ana S. Luis, Alan Cartmell, Zachary Armstrong, "Fluorogenic coupled assays reveal catalytic properties, inhibition constants and cellular location of mucin-active carbohydrate sulfatases", Angewandte Chemie International Edition, 597 (2026), DOI: 10.1002/anie.2991471
- Nikos Nikolopoulos, Yorgo Modis, "Crystal structure of HERV-K envelope glycoprotein surface subunit", Journal Of Virology (2026), DOI: 10.1128/jvi.00195-26
- Stephen Wood, Yiwei Guan, James Pitts, Raj Gill, Simon Kolstoe, Tamas Javorfi, Rohanah Hussain, Giuliano Siligardi, "Induced circular dichroism from the binding of achiral bivalent ligands to transthyretin", Journal Of Molecular Recognition, 39 (2026), DOI: 10.1002/jmr.70037
- Monisha Singha, Liam A. Wilson, Elisabete C. C. M. Moura, Maria M. Trush, Karina Calvopina, Gurleen Kaur, Greta Zaborskytė, Toms Kalniņš, Tharindi Panduwawala, Matthew J. Bowen, Matthew J. Beech, Jurgen Brem, Peter J. Mchugh, Edgars Suna, Timothy R. Walsh, Christopher J. Schofield, Alistair J. M. Farley, "Development of water-trapping pyrrole-2-carboxylic acids as broad-spectrum metallo-β-lactamase inhibitors", Journal Of Medicinal Chemistry (2026), DOI: 10.1021/acs.jmedchem.5c03534
- Michael J. Lambrecht, Jun Liang, Peter Man-Un Ung, Malcolm P. Huestis, Bing-Yan Zhu, Lisa M. Barton, Georgette M. Castanedo, Jason R. Zbieg, Robin Larouche-Gauthier, Araz Jakalian, Jean-Philippe Leclerc, Arun Yadav, Pouyan Haghshenas, Samuel Aubert-Nicol, Hossein Ismaili, Liang Zhao, Mélissa Leblanc, Jian Wang, Shouliang Wang, Qiuyue Wang, Thomas Garner, Sophia Tan, Madeleine Prangley, Fabio Broccatelli, Jodie Pang, Jeremy Murray, Christine Yu, Peter Hsu, Sascha Rutz, Satoko Kakiuchi-Kiyota, Isabel Ishizuka, Dennis H. Leung, Ponien Kou, Linda Bao, Xiaojing Wang, "Optimization and in vivo characterization of a series of Cbl-b inactive-state inhibitors", Acs Medicinal Chemistry Letters (2026), DOI: 10.1021/acsmedchemlett.6c00103
- Laura Ruduša, Sintija Ozola, Kostiantyn P. Melnykov, Yaroslav I. Filatov, Serhiy V. Ryabukhin, Raitis Bobrovs, Dmytro M. Volochnyuk, Kristaps Jaudzems, Rihards Aleksis, "Rapid fragment screening by 19F steady-state free precession NMR", Angewandte Chemie International Edition, 5 (2026), DOI: 10.1002/anie.6891540
- Benjamin T. W. Schwabe, Isabelle M. Angstman, Katharina Vollheyde, Zoe Ingold, Jiacheng Li, Ksenia S. Stankevich, Christopher D. Spicer, Martin A. Fascione, Gideon Grogan, Fernando Geu-Flores, Benjamin R. Lichman, "Nicotine biosynthesis is completed by cryptic activating glucosylation", Nature Communications, 17 (2026), DOI: 10.1038/s41467-026-72705-0
- Kalvis Brangulis, "The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error", Febs Open Bio, 35 (2026), DOI: 10.1002/2211-5463.70268
- Rebekah M. West, Radu Costin Bizga Nicolescu, Paul Brear, James Wagstaff, Beata K. Blaszczyk, Tomas Deingruber, Matthew G. Sanders, Francisco Javier Pérez-Areales, David R. Spring, Marko Hyvonen, "Targeting a pleckstrin homology domain with a lysine-reactive covalent binder", Journal Of Medicinal Chemistry (2026), DOI: 10.1021/acs.jmedchem.5c03818
- Huazhang Shu, Julian M. Ludäscher, Sushma Sharma, Seher Alam, Lilian Frank, Emma Scaletti Hutchinson, Marianna Tampere, Chloé Lévêque, André B. P. Van Kuilenburg, Nicholas C. K. Valerie, Mikael Altun, Andrei Chabes, Pal Stenmark, Sean G. Rudd, Si Min Zhang, "Uridine cytidine kinases govern molnupiravir bioactivation and anti-SARS-CoV-2 activity", Plos Pathogens, 22 (2026), DOI: 10.1371/journal.ppat.1014225
- [Thesis] Zhichun Lin, "Template technology for biocrystallization" (2026), DOI: 10.26174/thesis.lboro.32048493
- Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys, "The Mycobacterium tuberculosis Rv0132c gene product Mtb-FGD2 can act as an F420-dependent glucose dehydrogenase", Proteins: Structure, Function, And Bioinformatics, 124 (2026), DOI: 10.1002/prot.70139
- Robert L. Hudkins, Eric Allen, Samhita Iyer, Alexandra Balcer, Melissa Neal, Qing Ye, Marc Rideout, Caleb B. Frye, Kirk J. Nelson, Isaac D. Hoffman, Jacqueline H. Starrett, Todd Harris, Ronald V. Swanson, Daniel C. Bensen, "Structure-based design of a novel covalent 4-(1-methylindol-3-yl)pyrimidin-2-amine series targeting FGFR2 resistance mutations", Journal Of Medicinal Chemistry, 69, 8614 - 8627 (2026), DOI: 10.1021/acs.jmedchem.6c00514
- Robert P. Law, Ian D. Wall, Richard Lonsdale, Ross P. Hryczanek, Daniel Barker, Tim N. Barrett, Rino A. Bit, John J. Coward, Matthew W. Gray, Darren V. S. Green, Callum J. Hall, Ashley P. Hancock, Carl Haslam, David J. Hirst, Heather F. Hryczanek, Jonathan P. Hutchinson, Semra Kitchen, David Marcus, Jared Marklew, Joseph Mason, Nicholas D. Measom, Margarete Neu, Simon Peace, Alex Phillipou, Stephen D. Pickett, Peter Pogány, James Rowedder, Paul Rowland, Paul Scott-Stevens, Gail A. L. Seal, Hester Sheehan, Efstratios Stratikos, Chloe Tayler, Jonathan A. Taylor, Christopher P. Tinworth, Giovanni Vitulli, "Automated molecular design in BRADSHAW, applied to the optimization of ERAP1 inhibitors", Journal Of Medicinal Chemistry (2026), DOI: 10.1021/acs.jmedchem.5c03071
- Marie Bonnet-Di Placido, Helen M. E. Duyvesteyn, Angela W. Steyn, Abigail L. Hay, Claudine Porta, Kristel Ramirez Valdez, Elena Lokhman, Sylvia Crossley, Kevan Hanson, William N. Mwangi, Danish Munir, Eva Perez-Martin, Nick J. Knowles, Alison Burman, Abdelaziz A. Yassin, Amin Asfor, Cristina Faralla, Katherine J. Lam, Róisín Mccomb, Carina Leifeld, Kimberly Pietersz, Donald P. King, Erwin Van Den Born, Sherie K. Duncan, Bryan Charleston, Elizabeth E. Fry, Jingshan Ren, David I. Stuart, John A. Hammond, "Cattle antibodies identify a cross-serotype broadly neutralising foot-and-mouth disease virus epitope", Npj Vaccines, 450 (2026), DOI: 10.1038/s41541-026-01427-7
- Fatma Işık Üstok, Alexandre Faille, Alan J. Warren, James A. Huntington, "Prothrombinase processivity is conferred by substrate allostery", The Embo Journal, 630 (2026), DOI: 10.1038/s44318-026-00782-4
- Olesia Werbowy, Maria Håkansson, Sebastian Dorawa, Aleksandra Stefańska-Kaźmierczak, L. Anders Svensson, Salam Al-Karadaghi, Agata Jurczak-Kurek, Karolina Kwiatkowska-Semrau, Magdalena Plotka, Olafur H. Fridjonsson, Gudmundur O. Hreggvidsson, Arnthór Aevarsson, Sławomir Dąbrowski, Anna‐karina Kaczorowska, Tadeusz Kaczorowski, "Structural and functional characterization of a hyperthermostable single‐stranded DNA ‐binding protein from a hot spring metagenome", Protein Science, 35 (2026), DOI: 10.1002/pro.70538
- Ahmed Shemy, Jana Van Broeckhoven, Niels Hellings, Arnout Voet, "The human TIMP-1 unbound structure provides a platform for fragment screening", Acta Crystallographica Section D Structural Biology, 82 (2026), DOI: 10.1107/S2059798326001749
- Stefania Patti, Simone A. De Rose, Michail N. Isupov, Ilya V. Kublanov, Ilaria Magrini Alunno, Sergio Riva, Ivan Bassanini, Eleonora Dore, Christina Stracke, Bettina Siebers, Erica Elisa Ferrandi, Jennifer A. Littlechild, Daniela Monti, "Discovery and characterization of novel 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthase from thermophilic (meta)genomes", Catalysts, 16 (2026), DOI: 10.3390/catal16040305
- J. Maximilian Fels, Aidan B. Hill, Richard Han, Jasmine M. Garcia, Hugo Bisio, Chantal Abergel, Philip J. Kranzusch, Amy S. Y. Lee, "Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life", Cell, 189, 1423 - 1433.e16 (2026), DOI: 10.1016/j.cell.2026.01.008
- Malcolm F. White, Stephen A. Mcmahon, Haotian Chi, Shirley Graham, "The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence", Biochemical Journal (2026), DOI: 10.1042/BCJ20260019
- Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill, "Evolutionarily divergent DUF4465 domains have a common vitamin B12 ‐binding function", Febs Open Bio, 369 (2026), DOI: 10.1002/2211-5463.70231
- Elinor Morris, Boris Lozhkin, Jan Uhrhan, Indrek Kalvet, Sophie Basler, Roman P. Jakob, David Baker, Thomas R. Ward, "Design, optimization and characterization of a de novo gold hydroaminase", Acs Catalysis (2026), DOI: 10.1021/acscatal.5c08100
- Yihong Sun, Siddhant Dhingra, Mark D. Allen, Ethan S. Z. Cheng, Zhihong Zhang, Christopher J. Schofield, Lennart Brewitz, "Structural and functional validation of Pseudomonas savastanoi ethylene forming enzymes reveals flexibility in 2-oxoglutarate binding mode and conformation", Chembiochem, 27 (2026), DOI: 10.1002/cbic.202500702
- Rosaria Gandini, Markus M. Keskitalo, Tom Reichenbach, Dayanand C. Kalyani, Christina Divne, "Crystallographic data for Pyrococcus furiosus dolichylphosphate mannose synthase suggest that the enzyme could flip its glycolipid product", Scientific Reports, 16 (2026), DOI: 10.1038/s41598-026-44343-5
- Arashdeep Kaur, Ruby K. Williams, Shuxin Yang, Mihwa Lee, Niccolay Madiedo Soler, Ethan D. Goddard-Borger, Gideon J. Davies, Mahima Sharma, Spencer J. Williams, "Metal-dependent 2-keto-3,6-dideoxy-6-sulfo-gluconate (KDSG) aldolase: decoding the key C-C bond cleaving step in bacterial sulfoglycolysis", Chemistry – A European Journal, 28 (2026), DOI: 10.1002/chem.70857
- Zhanna Romanyuk, Giacomo Bettin, Paul Brear, Sara Linciano, Ylenia Mazzocato, Simone Bonadies, Ilaria Zanotto, Camilla Mazzucco, Alan Monferone, Miguel A. Soler, Gianfranco Pasut, Sara De Martin, Alessandro Scarso, Christian Heinis, Sylvia Rothenberger, Marko Hyvonen, Alessandro Angelini, "Yeast display technology enables rapid discovery of low-nanomolar macrocyclic peptide inhibitors of human angiotensin-converting enzyme 2", Journal Of Medicinal Chemistry, 7 (2026), DOI: 10.1021/acs.jmedchem.5c02876
- David Carling, Shu-Yang Chen, Jane Bennett, Naveenan Navaratnam, Rebeca Fiadeiro, Angela Woods, Alex Montoya, Pavel Shliaha, Simone Kunzelmann, Steven A. Howell, Shahid Mehmood, Andrew G. Purkiss, Jon R. Wilson, Steven J. Gamblin, "Binding of 14-3-3 stabilises recombinant AMPKγ2-containing complexes", Biochemical Journal (2026), DOI: 10.1042/BCJ20250342
- Mariska De Munnik, Amelia Brasnett, Tiankun Zhou, William Myers, Yicheng Wang, Kuntal Chatterjee, Anthony Tumber, Stephen A. Marshall, Philipp S. Simon, Pierre Aller, Anastasiia Shilova, Danny Axford, Hiroki Makita, Daniel W. Paley, Vandana Tiwari, Alexander T. Stead, Sebastian Dehe, Humberto Sanchez, Daniel J. Rosenberg, Roberto Alonso-Mori, Asmit Bhowmick, Junko Yano, Vittal K. Yachandra, Jaehyun Park, Sehan Park, Allen M. Orville, Lennart Brewitz, Jan F. Kern, Christopher J. Schofield, Patrick Rabe, "Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase", Nature Communications, 30 (2026), DOI: 10.1038/s41467-026-69425-w
- Céline Zheng-Gérard, Jana Joha, Maria Carrasquero, Kamel El Omari, Edward Lowe, Shirish Dubey, Simon J. Draper, Yu-Chi Chang, Hsi-Hsien Lin, Alan D. Salama, Kirsty Mchugh, Elena Seiradake, "Structures of proteinase 3 and the CD177 receptor complex reveal a major autoantibody epitope", Embo Reports, 161 (2026), DOI: 10.1038/s44319-026-00716-5
- Sonomi Yamaguchi, Samantha G. Fernandez, Douglas R. Wassarman, Marlen Lüders, Frank Schwede, Philip J. Kranzusch, "Nucleotide signals coordinate activation and inhibition of bacterial immunity", Nature, 480 (2026), DOI: 10.1038/s41586-026-10135-0
- Harry M. Williams, Alastair Watson, Jens Madsen, Howard W. Clark, Derek W. Hood, Stefan Oscarson, Trevor J. Greenhough, Annette K. Shrive, "Phosphorylation of inner core heptose is a major determinant of bacterial surface lipopolysaccharide recognition by the innate immune protein hSP-D", Journal Of Biological Chemistry, 164 (2026), DOI: 10.1016/j.jbc.2026.111307
- Dorin Kalson, Jeremiah S. Joseph, Hila Nudelman, Eyal Kamhi, Shlomo Bakshi, "Disulfide bond mapping of follitropin delta, a recombinant follicle stimulating hormone (rFSH), by X-ray crystallography", Pharmaceuticals, 19 (2026), DOI: 10.3390/ph19030380
- Emma Tarrant, Isabel G. Cormack, Charlotte E. Hunter, Olesia Werbowy, Sebastian Dorawa, Lei Wang, Ida Helene Steen, Ruth-Anne Sandaa, Elísabet Eik Guðmundsdóttir, Bernd Ketelsen-Striberny, Anna-Karina Kaczorowska, Tadeusz Kaczorowski, Ehmke Pohl, Stefanie Freitag-Pohl, "Structure, function, and applications of two novel phage recombinases from extreme environments", Nucleic Acids Research, 54 (2026), DOI: 10.1093/nar/gkag069
- E. S. Mackenzie, K. M. Sendra, A. Basle, R. Mazgaj, T. E. Kehl-Fie, K. J. Waldron, "An enzyme's metal preference evolves through redox modulation driven by the cofactor’s secondary coordination sphere", Molecular Biology And Evolution (2026), DOI: 10.1093/molbev/msag040
- Jesse A. Coker, Rong Sun, Paul M. Polzer, Todd Romigh, Christopher M. Goins, Nancy S. Wang, Jae U. Jung, Shaun R. Stauffer, "Fragment-based development of NSP14 exonuclease inhibitors confounded by batch-to-batch variability", Acs Chemical Biology (2026), DOI: 10.1021/acschembio.5c00930
- Claire Morley, Alexandra J. Munro-Clark, Ben A. Wagstaff, Irina Ivanova, Evgenia Dubinskaya, Ava Rostock, Mary Ortmayer, Colin W. Levy, Robert A. Field, "Structure and characterisation of CMP-Kdn synthetase from the haptophyte microalgae Prymnesium parvum", Rsc Chemical Biology, 14 (2026), DOI: 10.1039/D5CB00285K
- Danai Mavridi, Julianne S. Funk, Dimitrios-Ilias Balourdas, Andreas Kramer, Raysa Khan Tareque, Oleg Timofeev, John Spencer, Thorsten Stiewe, Andreas C. Joerger, "Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt", Cell Death & Disease, 85 (2026), DOI: 10.1038/s41419-026-08492-9
- Catherine T. Fletcher, Abigail A. Mornement, Charlotte Barrett, Peter Canning, Prakash Rucktooa, Sophie Huber, Christopher Cooper, Conor C. G. Scully, Andrew S. Dore, Daniel Rohle, Geoffrey M. T. Smith, Sarah E. Skerratt, Amanda J. Kennedy, "Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery", Communications Biology, 9 (2026), DOI: 10.1038/s42003-026-09584-0
- Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C. Dorfmueller, Daniel M. F. Van Aalten, "Cell wall target fragment discovery using a low‐cost, minimal fragment library", Febs Letters, 12 (2026), DOI: 10.1002/1873-3468.70281
- Tina Drobnič, Ralf Salzer, Tim Nierhaus, Margaret Ke Xin Jiang, Dom Bellini, Astrid Steindorf, Sonja-Verena Albers, Buzz Baum, Jan Lowe, "Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery", Proceedings Of The National Academy Of Sciences, 123 (2026), DOI: 10.1073/pnas.2525941123
- Markella Konstantinidou, Holly R. Vickery, Marloes A. M. Pennings, Johanna M. Virta, Shu Yue Luo, Emira J. Visser, Sean D. Bannier, Mrudula Srikanth, Sabine Z. Cismoski, Lucy C. Young, Maxime C. M. Van Den Oetelaar, Frank Mccormick, Christian Ottmann, Luc Brunsveld, Michelle R. Arkin, "Modulation of the 14-3-3σ/C-RAF “auto” inhibited complex by molecular glues", Journal Of The American Chemical Society (2026), DOI: 10.1021/jacs.5c12622
- Chongxun Ge, Dazhi Feng, Song Shi, Xuzhen Tang, Yaqi Cui, Song Liu, Yunyue Wang, Shuangtian Tang, Xinnan Li, Xianqiang Sun, Daopeng Yuan, Jinyi Xu, Hu He, Hong Yao, "Discovery of SY-589, a highly potent and orally bioavailable Polθ helicase inhibitor for the treatment of HR-deficient tumors", Journal Of Medicinal Chemistry (2026), DOI: 10.1021/acs.jmedchem.5c02689
- Daniel A. Bonsor, Lorenzo I. Finci, Jacob R. Potter, Lucy C. Young, Vanessa E. Wall, Ruby Goldstein De Salazar, Katie R. Geis, Tyler Stephens, Joseph Finney, Dwight V. Nissley, Frank Mccormick, Dhirendra Simanshu, "Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors", Nature Communications, 16 (2026), DOI: 10.1038/s41467-026-68319-1
- Heiner G. Weddeling, Sven T. Sowa, Elena Bialas, Sven Reese, Christian Merten, Markus Lill, Andreas Bechthold, Robin Teufel, "A hooker oxygenase archetype in polyketide biosynthesis challenging the Baeyer–Villiger monooxygenase paradigm", Journal Of The American Chemical Society (2026), DOI: 10.1021/jacs.5c21759
- Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder, "C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐ CoA lyase", Febs Open Bio, 11 (2026), DOI: 10.1002/2211-5463.70199
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