Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I03 Contact
Beamline Phone Number:
+44 (0) 1235 778707
Acting Principal Beamline Scientist:
Dave Hall
Tel: +44 (0) 1235 778926
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I03 MX
Status: Operational
Beamsize: 90 µm x 20 µm
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
These publications are based on data gathered on beamline I03. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
102 items found for 2011 [total: 2353]
Structures of engineered Clostridium botulinum neurotoxin derivatives Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (12) Dec 2011 DOI: 10.1107/S1744309111034671
Recognition of dual symmetry by the controller protein C.Esp1396I based on the structure of the transcriptional activation complex Nucleic Acids Research, 40 (9) Dec 2011 DOI: 10.1093/nar/gkr1250
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT Molecular Cell, 44 (6) Dec 2011 DOI: 10.1016/j.molcel.2011.10.020
Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension Science, 332 Dec 2011 DOI: 10.1126/science.1200840
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms. Journal Of Molecular Biology, 405 (1) Dec 2011 DOI: 10.1016/j.jmb.2010.10.024
Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1 Nature Structural & Molecular Biology, 18 (8) Dec 2011 DOI: 10.1038/nsmb.2081
Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13 Structure, 19 (7) Dec 2011 DOI: 10.1016/j.str.2011.03.023
Challenges of sulfur SAD phasing as a routine method in macromolecular crystallography Journal Of Synchrotron Radiation, 19 (1) Dec 2011 DOI: 10.1107/S0909049511049004
The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly Febs Journal, Dec 2011 DOI: 10.1111/j.1742-4658.2011.08461.x
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis Proceedings Of The National Academy Of Sciences, Dec 2011 DOI: 10.1073/pnas.1113921108
PCNA directs type 2 RNase H activity on DNA replication and repair substrates Nucleic Acids Research, 39 (9) Dec 2011 DOI: 10.1093/nar/gkq980
Cloning, purification and crystallographic analysis of a hypothetical protein, BPSL1549, from Burkholderia pseudomallei. Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (12) Dec 2011 DOI: 10.1107/S1744309111028995
Journal Paper I03-Macromolecular Crystallography
Inhibition of apoptosis and NF- kappa B activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence Plos Pathogens, 7 Dec 2011 DOI: 10.1371/journal.ppat.1002430
Structural basis for cell surface patterning through NetrinG-NGL interactions The Embo Journal, 30 (21) Dec 2011 DOI: 10.1038/emboj.2011.346
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
A dual binding mode for RhoGTPases in plexin signalling Plos Biology, 9 (8) Dec 2011 DOI: 10.1371/journal.pbio.1001134
Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII Journal Of Molecular Biology, Nov 2011 DOI: 10.1016/j.jmb.2011.10.036
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase Molecular Cell, 44 (3) Nov 2011 DOI: 10.1016/j.molcel.2011.08.036
Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation Structure, 19 (11) Nov 2011 DOI: 10.1016/j.str.2011.08.014
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure and kinetic stability of the p63 tetramerization domain Journal Of Molecular Biology, Nov 2011 DOI: 10.1016/j.jmb.2011.11.007
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes Journal Of Medicinal Chemistry, 55 (1) Nov 2011 DOI: 10.1021/jm201140v
Journal Paper I03-Macromolecular Crystallography
Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases Oncogene, Nov 2011 DOI: 10.1038/onc.2011.532
Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor Febs Journal, Nov 2011 DOI: 10.1111/j.1742-4658.2011.08414.x
Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales Proceedings Of The National Academy Of Sciences, Nov 2011 DOI: 10.1073/pnas.1113277108
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM Cell, 147 (5) Nov 2011 DOI: 10.1016/j.cell.2011.10.038
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
A novel technique combining high-resolution synchrotron x-ray microtomography and x-ray diffraction for characterization of micro particulates Measurement Science And Technology, 22 (11) Nov 2011 DOI: 10.1088/0957-0233/22/11/115703
Journal Paper I03-Macromolecular Crystallography
Kinked b-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL Proceedings Of The National Academy Of Sciences, Oct 2011 DOI: 10.1073/pnas.1105211108
High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins Molecular Membrane Biology, 28 (7-8) Oct 2011 DOI: 10.3109/09687688.2011.628954
Journal Paper I03-Macromolecular Crystallography
Characterisation of an oxidoreductase from the Arylamine N-acetyltransferase operon in Mycobacterium smegmatis Febs Journal, Oct 2011 DOI: 10.1111/j.1742-4658.2011.08382.x
Journal Paper I03-Macromolecular Crystallography
X-ray structure of the dimeric cytochrome bc1 complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution Biochimica Et Biophysica Acta (bba) - Bioenergetics, Oct 2011 DOI: 10.1016/j.bbabio.2011.09.017
Journal Paper I03-Macromolecular Crystallography
Structural variability of the ubiquitin specific protease DUSP-UBL double domains Febs Letters, Oct 2011 DOI: 10.1016/j.febslet.2011.09.040
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystal structure of reduced and of oxidized peroxiredoxin IV reveals a stable oxidized decamer and a non disulfide-bonded intermediate in the catalytic cycle Journal Of Biological Chemistry, Oct 2011 DOI: 10.1074/jbc.M111.298810
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Ex situ and in situ methods of inspecting and optimizing adaptive bimorph mirrors Diamond Light Source Proceedings, 1 Oct 2011 DOI: 10.1017/S2044820110000225
Conference Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I07-Surface & interface diffraction I19-Small Molecule Single Crystal Diffraction
Structural basis for the broad tissue tropism of the pathogenic fungus Candida Albicans Proceedings Of The National Academy Of Sciences, Sept 2011 DOI: 10.1073/pnas.1103496108
Structural analysis of human FANCL, the E3 ligase in the fanconi anemia pathway Journal Of Biological Chemistry, 286 (37) Sept 2011 DOI: 10.1074/jbc.M111.244632
Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT Nature, Sept 2011 DOI: 10.1038/nature10450
Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin Biochemical Journal, 438 (2) Sept 2011 DOI: 10.1042/BJ20101316
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A widespread family of bacterial cell wall assembly proteins The Embo Journal, Sept 2011 DOI: 10.1038/emboj.2011.358
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Expression, purification and crystallization of Neisserial outer membrane proteins Sept 2011 DOI: 10.1007/978-1-61779-346-2_6
Book Chapter I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27: a new member of the Haloalkanoic Acid Dehalogenase superfamily Biochemistry, Sept 2011 DOI: 10.1021/bi201171h
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Non-equivalent role of inter- and intra-molecular hydrogen bonds in the insulin dimer interface Journal Of Biological Chemistry, Sept 2011 DOI: 10.1074/jbc.M111.265249
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure of a Streptomyces maltosyltransferase GlgE: a homologue of a genetically validated anti-tuberculosis target Journal Of Biological Chemistry, Sept 2011 DOI: 10.1074/jbc.M111.279315
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Engineering and characterisation of novel protein covalent linkages in horseradish peroxidase (HRP) : effect on structure and function Sept 2011
Thesis I03-Macromolecular Crystallography
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 Influenza a hemagglutinins Science, 333 Aug 2011 DOI: 10.1126/science.1205669
Journal Paper I03-Macromolecular Crystallography
Insights into Krabbe disease from structures of galactocerebrosidase Proceedings Of The National Academy Of Sciences, Aug 2011 DOI: 10.1073/pnas.1105639108
Structure and organisation of SinR, the master regulator of biofilm formation in Bacillus subtilis Journal Of Molecular Biology, 411 (3) Aug 2011 DOI: 10.1016/j.jmb.2011.06.004
The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding Nucleic Acids Research, Aug 2011 DOI: 10.1093/nar/gkr640
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H Acta Crystallographica Section D Biological Crystallography, 67 (7) Jul 2011 DOI: 10.1107/S0907444911015423
Journal Paper I03-Macromolecular Crystallography
Structure and mechanism of human UDP-glucose 6-dehydrogenase Journal Of Biological Chemistry, 286 (27) Jul 2011 DOI: 10.1074/jbc.M111.234682
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site Journal Of Biological Chemistry, 286 (36) Jul 2011 DOI: 10.1074/jbc.M110.212613
Molecular recognition of chymotrypsin by the serine protease inhibitor ecotin from Yersinia pestis Journal Of Biological Chemistry, 286 (27) Jul 2011 DOI: 10.1074/jbc.M111.225730
Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 Å resolution Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (7) Jul 2011 DOI: 10.1107/S1744309111017453
Journal Paper I03-Macromolecular Crystallography
Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572) Molecular Pharmacology, Jul 2011 DOI: 10.1124/mol.111.073189
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90 The Faseb Journal, Jul 2011 DOI: 10.1096/fj.11-188821
Simultaneous X-ray diffraction from multiple single crystals of macromolecules Acta Crystallographica Section D Biological Crystallography, 67 (7) June 2011 DOI: 10.1107/S0907444911015617
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structure of a pentavalent G-actin•MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator Science Signaling, 4 (177) June 2011 DOI: 10.1126/scisignal.2001750
Journal Paper I03-Macromolecular Crystallography
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor Genes & Development, 25 (12) June 2011 DOI: 10.1101/gad.2056211
The virulence factor PEB4 (Cj0596) and the periplasmic protein Cj1289 are two structurally related SurA-like chaperones in the human pathogen Campylobacter jejuni Journal Of Biological Chemistry, 286 (24) June 2011 DOI: 10.1074/jbc.M111.220442
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Mapping lipid and detergent molecules at the surface of membrane proteins June 2011 DOI: 10.1042/BST0390775
Conference Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
X-ray crystallographic structure of the murine norovirus protease at 1.66 Å resolution and functional studies of the β-ribbon June 2011
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Complementary structural studies of C-reactive protein complexed with natural ligands June 2011
Thesis B23-Circular Dichroism I03-Macromolecular Crystallography
The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development Biochemical Journal, 437 (3) May 2011 DOI: 10.1042/BJ20110345
Journal Paper I03-Macromolecular Crystallography
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming Proceedings Of The National Academy Of Sciences, 108 (19) May 2011 DOI: 10.1073/pnas.1101262108
Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects Journal Of Synchrotron Radiation, 18 (3) May 2011 DOI: 10.1107/S0909049511008235
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Crystal structures of ABL-related gene (ABL2) in Complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class Journal Of Medicinal Chemistry, 54 (7) Apr 2011 DOI: 10.1021/jm101506n
Structure and activity of a functional derivative of Clostridium botulinum neurotoxin Journal Of Structural Biology, 174 (1) Apr 2011 DOI: 10.1016/j.jsb.2010.11.010
Journal Paper I03-Macromolecular Crystallography
Expression, crystallization and preliminary X-ray data analysis of NT-ALS9, a fungal adhesin from Candida albicans Acta Crystallographica Section F Structural Biology And Crystallization Communications, Apr 2011 DOI: 10.1107/S1744309111003460
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1 Angewandte Chemie International Edition, 50 (17) Apr 2011 DOI: 10.1002/anie.201008019
Helix-mediated protein-protein interactions as targets for intervention using foldamers Amino Acids, Mar 2011 DOI: 10.1007/s00726-011-0880-8
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structure of mammalian AMPK and its regulation by ADP Nature, 472 Mar 2011 DOI: 10.1038/nature09932
Journal Paper I03-Macromolecular Crystallography
Novel ligands for a purine riboswitch discovered by RNA-ligand docking Chemistry - A European Journal, 18 (3) Mar 2011 DOI: 10.1016/j.chembiol.2010.12.020
Dynamics and allosteric potential of the AMPA receptor N-terminal domain The Embo Journal, 30 (5) Mar 2011 DOI: 10.1038/emboj.2011.17
Journal Paper I03-Macromolecular Crystallography
Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers The Embo Journal, 30 (5) Mar 2011 DOI: 10.1038/emboj.2011.16
Journal Paper I03-Macromolecular Crystallography
Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS Biochemical Journal, 435 (2) Mar 2011 DOI: 10.1042/BJ20101442
Journal Paper I03-Macromolecular Crystallography
Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy Chemical Biology And Drug Design, Mar 2011 DOI: 10.1111/j.1747-0285.2011.01091.x
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship Journal Of Medicinal Chemistry, 54 (6) Mar 2011 DOI: 10.1021/jm1011726
Journal Paper I03-Macromolecular Crystallography
Crystallization and preliminary X-ray analysis of the TetR-like efflux pump regulator SimR Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (3) Feb 2011 DOI: 10.1107/S1744309110053078
Journal Paper I03-Macromolecular Crystallography
Conformational flexibility of the ligand-binding domain dimer in kainate receptor gating and desensitization Journal Of Neuroscience, 31 (8) Feb 2011 DOI: 10.1523/JNEUROSCI.4771-10.2011
A hyperactive cobalt-substituted extradiol-cleaving catechol dioxygenase Journal Of Biological Chemistry, 16 (2) Feb 2011 DOI: 10.1007/s00775-010-0732-0
Journal Paper I03-Macromolecular Crystallography
Novel mechanism of inhibition of human Angiotensin-I converting enzyme (ACE) by a highly specific phosphinic tripeptide Biochemical Journal, Feb 2011 DOI: 10.1042/BJ20102123
Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression Journal Of Molecular Biology, Feb 2011 DOI: 10.1016/j.jmb.2011.02.035
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Substrate and metal-ion promiscuity in mannosylglycerate synthase Journal Of Biological Chemistry, Feb 2011 DOI: 10.1074/jbc.M110.199844
Structure−activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5 Journal Of Medicinal Chemistry, 54 (6) Feb 2011 DOI: 10.1021/jm100991m
Journal Paper I03-Macromolecular Crystallography
Crystal structure of R120G disease mutant of human αB-crystallin domain dimer shows closure of a groove Journal Of Molecular Biology, 408 (1) Feb 2011 DOI: 10.1016/j.jmb.2011.02.020
Regulation of an intracellular subtilisin protease activity by a short propeptide sequence through an original combined dual mechanism Proceedings Of The National Academy Of Sciences, Feb 2011 DOI: 10.1073/pnas.1014229108
Journal Paper I03-Macromolecular Crystallography
Structural basis for engagement by complement factor H of C3b on a self surface Nature Structural & Molecular Biology, 18 (4) Feb 2011 DOI: 10.1038/nsmb.2018
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response The Embo Journal, 30 (5) Feb 2011 DOI: 10.1038/emboj.2011.18
Structure and mechanism of the chalcogen detoxifying protein TehB from Escherichia coli Biochemical Journal, Jan 2011 DOI: 10.1042/BJ20102014
Structure of rhomboid protease in a lipid environment Journal Of Molecular Biology, Jan 2011 DOI: 10.1016/j.jmb.2011.01.029
Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones Plos One, Jan 2011 DOI: 10.1371/journal.pone.0016583
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Phosphotyrosine recognition by the Raf kinase inhibitor protein Onco Therapeutics, 2(1) Jan 2011 DOI: 10.1615/ForumImmunDisTher.v2.i1.70
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Monitoring and validating active site redox states in protein crystals Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, Jan 2011 DOI: 10.1016/j.bbapap.2010.12.017
Journal Paper I03-Macromolecular Crystallography
The structure of human complement factor I Jan 2011
Conference Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery Nature Structural & Molecular Biology, 18 (2) Jan 2011 DOI: 10.1038/nsmb.1983
Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2 Journal Of Medicinal Chemistry, 54 (2) Jan 2011 DOI: 10.1021/jm101150b
Journal Paper I03-Macromolecular Crystallography
Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2. The Embo Journal, Jan 2011 DOI: 10.1038/emboj.2010.309
Crystal structure of DNA polymerase III β sliding clamp from Mycobacterium tuberculosis Biochemical And Biophysical Research Communications, Jan 2011 DOI: 10.1016/j.bbrc.2011.01.027
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium Nucleic Acids Research, 39 (1) Jan 2011 DOI: 10.1093/nar/gkq1296
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases Journal Of Biological Chemistry, 286 (15) Jan 2011 DOI: 10.1074/jbc.M110.206771
Extending the usability of the phasing power of diselenide bonds: SeCys SAD phasing of CsgC using a non-auxotrophic strain Acta Crystallographica Section D, 67 Jan 2011 DOI: 10.1107/S0907444910042022
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
A processed noncoding RNA regulates an altruistic bacterial antiviral system Nature Structural & Molecular Biology, 18 (2) Jan 2011 DOI: 10.1038/nsmb.1981
Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain Journal Of Biological Chemistry, 286 (5) Jan 2011 DOI: 10.1074/jbc.M110.188193
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors Cancer Research, 71 (2) Jan 2011 DOI: 10.1158/0008-5472.CAN-10-1252
Journal Paper I03-Macromolecular Crystallography
- Geoffrey Masuyer, Patrick Stancombe, John A. Chaddock, K. Ravi Acharya, "Structures of engineered Clostridium botulinum neurotoxin derivatives", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (12), 1466 - 1472 (2011), DOI: 10.1107/S1744309111034671
- J. E. Mcgeehan, N. J. Ball, S. D. Streeter, S.-J. Thresh, G. G. Kneale, "Recognition of dual symmetry by the controller protein C.Esp1396I based on the structure of the transcriptional activation complex", Nucleic Acids Research, 40 (9), 4158-4167. (2011), DOI: 10.1093/nar/gkr1250
- Jing Yang, Kiran Kulkarni, Ioannis Manolaridis, Ziguo Zhang, Roger b. Dodd, Corine Mas-Droux, David Barford, "Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT", Molecular Cell, 44 (6), 997 - 1004 (2011), DOI: 10.1016/j.molcel.2011.10.020
- Charlotte H. Coles, Yingjie Shen, Alan P. Tenney, Christian Siebold, Geoffrey C. Sutton, Weixian Lu, John T. Gallagher, E. Yvonne Jones, John G. Flanagan, Alexandru Aricescu, "Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension", Science, 332 (2011), DOI: 10.1126/science.1200840
- Sarah Sainsbury, Louise Bird, Vincenzo Rao, Sharon M. Shepherd, David I. Stuart, William N. Hunter, Raymond J. Owens, Jingshan Ren, "Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms.", Journal Of Molecular Biology, 405 (1), 173-184 (2011), DOI: 10.1016/j.jmb.2010.10.024
- Tomas Malinauskas, Alexandru Aricescu, Weixian Lu, Christian Siebold, E. Yvonne Jones, "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1", Nature Structural & Molecular Biology, 18 (8), 886-893 (2011), DOI: 10.1038/nsmb.2081
- Mohammad W Bahar, Stephen C. Graham, David I. Stuart, Jonathan M. Grimes, "Insights into the evolution of a complex virus from the crystal structure of vaccinia virus D13", Structure, 19 (7), 1011 - 1020 (2011), DOI: 10.1016/j.str.2011.03.023
- James Doutch, Michael A. Hough, S. Samar Hasnain, Richard W. Strange, "Challenges of sulfur SAD phasing as a routine method in macromolecular crystallography", Journal Of Synchrotron Radiation, 19 (1), 19-29 (2011), DOI: 10.1107/S0909049511049004
- Nia L. Marrott, Jacqueline J. T. Marshall, Dmitri I. Svergun, Susan J. Crennell, David W. Hough, Michael J. Danson, Jean M. H. Van Den Elsen, "The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly", Febs Journal (2011), DOI: 10.1111/j.1742-4658.2011.08461.x
- Apirat Chaikuad, D. Sean Froese, Georgina Berridge, Frank Von Delft, Udo Oppermann, Wyatt W. Yue, "Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis", Proceedings Of The National Academy Of Sciences (2011), DOI: 10.1073/pnas.1113921108
- Doryen Bubeck, Martin A. M. Reijns, Stephen C. Graham, Katy R. Astell, E. Yvonne Jones, Andrew P. Jackson, "PCNA directs type 2 RNase H activity on DNA replication and repair substrates", Nucleic Acids Research, 39 (9), 3652-3666 (2011), DOI: 10.1093/nar/gkq980
- Abimael Cruz-Migoni, Sergey N. Ruzheinikov, Svetlana E. Sedelnikova, Barbara Obeng, Sylvia Chieng, Rahmah Mohamed, Sheila Nathan, Patrick J. Baker, David W. Rice, "Cloning, purification and crystallographic analysis of a hypothetical protein, BPSL1549, from Burkholderia pseudomallei.", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (12), 1623 - 1626 (2011), DOI: 10.1107/S1744309111028995
- Carlos Maluquer De Motes, Samantha Cooray, Hongwei Ren, Gabriel M. F. Almeida, Kieran Mcgourty, Mohammad W. Bahar, David I. Stuart, Jonathan M. Grimes, Stephen C. Graham, Geoffrey L. Smith, "Inhibition of apoptosis and NF- kappa B activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence", Plos Pathogens, 7 (2011), DOI: 10.1371/journal.ppat.1002430
- Elena Seiradake, Charlotte H. Coles, Pavel V Perestenko, Karl Harlos, Robert A. J. Mcilhinney, E. Yvonne Jones, Alexandru Radu Aricescu, "Structural basis for cell surface patterning through NetrinG-NGL interactions", The Embo Journal, 30 (21), 4479 - 4488 (2011), DOI: 10.1038/emboj.2011.346
- Christian H. Bell, E. Yvonne Jones, Christian Siebold, A. Radu Aricescu, "A dual binding mode for RhoGTPases in plexin signalling", Plos Biology, 9 (8) (2011), DOI: 10.1371/journal.pbio.1001134
- Martin C. Moncrieffe, Maria-Jose Fernandez, Dieter Spiteller, Hiroyoshi Matsumura, Nicholas J. Gay, Ben F. Luisi, Peter F. Leadlay, "Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII", Journal Of Molecular Biology (2011), DOI: 10.1016/j.jmb.2011.10.036
- Fernando Garces, Laurence H. Pearl, Antony W. Oliver, "The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase", Molecular Cell, 44 (3), 385 - 396 (2011), DOI: 10.1016/j.molcel.2011.08.036
- Alexandre R. Gingras, Umakhanth Venkatraman Girija, Anthony H. Keeble, Roshni Panchal, Daniel A. Mitchell, Peter C. E. Moody, Russell Wallis, "Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation", Structure, 19 (11), 1635 - 1643 (2011), DOI: 10.1016/j.str.2011.08.014
- Eviata Najan, Andreas Christian Joerger, "Structure and kinetic stability of the p63 tetramerization domain", Journal Of Molecular Biology (2011), DOI: 10.1016/j.jmb.2011.11.007
- Nancy H. Campbell, Nurul H. Abd Karim, Gary N. Parkinson, Mekala Gunaratnam, Vanessa Petrucci, Alan K. Todd, Ramon Vilar, Stephen Neidle, "Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes", Journal Of Medicinal Chemistry, 55 (1) (2011), DOI: 10.1021/jm201140v
- W.-C. Hon, A. Berndt, R. L. Williams, "Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases", Oncogene (2011), DOI: 10.1038/onc.2011.532
- Geoffrey Masuyer, Talat Jabeen, Christopher T. Öberg, Hakon Leffler, Ulf J. Nilsson, K. Ravi Acharya, "Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor", Febs Journal (2011), DOI: 10.1111/j.1742-4658.2011.08414.x
- Sonia Paytubi, Stephen A. Mcmahon, Shirley Graham, Huanting Liu, Catherine H. Botting, Kira S. Makarova, Eugene V. Koonin, James H. Naismith, Malcolm F. White, "Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales", Proceedings Of The National Academy Of Sciences (2011), DOI: 10.1073/pnas.1113277108
- Sharon Miller, Daniela Sahlender, Stephen C. Graham, Stefan Honing, Margaret S. Robinson, Andrew A. Peden, David J. Owen, "The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM", Cell, 147 (5), 1118 - 1131 (2011), DOI: 10.1016/j.cell.2011.10.038
- David R. Merrifield, Vasuki Ramachandran, Kevin J. Roberts, Wes Armour, Danny Axford, Mark Basham, Gwyndaf Evans, Katherine E. Mcauley, Robin L. Owen, James Sandy, Thomas Connolley, "A novel technique combining high-resolution synchrotron x-ray microtomography and x-ray diffraction for characterization of micro particulates", Measurement Science And Technology, 22 (11) (2011), DOI: 10.1088/0957-0233/22/11/115703
- Huw Jenkins, Bara Malkova, Thomas A. Edwards, "Kinked b-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL", Proceedings Of The National Academy Of Sciences (2011), DOI: 10.1073/pnas.1105211108
- Mads Gabrielsen, Frank Kroner, Isobel Black, Neil W. Isaacs, Andrew J. Roe, Karen Mcluskey, "High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins", Molecular Membrane Biology, 28 (7-8), 445 - 453 (2011), DOI: 10.3109/09687688.2011.628954
- Dimitrios Evangelopoulos, Nora Cronin, Tina Daviter, Edith Sim, Nicholas H. Keep, Sanjib Bhakta, "Characterisation of an oxidoreductase from the Arylamine N-acetyltransferase operon in Mycobacterium smegmatis", Febs Journal (2011), DOI: 10.1111/j.1742-4658.2011.08382.x
- Thomas Kleinschroth, Michela Castellani, Chi Hung Trinh, Nina Morgner, Bernhard Brutschy, Bernd Ludwig, Carola Hunte, "X-ray structure of the dimeric cytochrome bc1 complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution", Biochimica Et Biophysica Acta (bba) - Bioenergetics (2011), DOI: 10.1016/j.bbabio.2011.09.017
- Paul R. Elliott, Han Liu, Martyna W. Pastok, Guenter J. Grossmann, Daniel J. Rigden, Michael J. Clague, Sylvie Urbé, Igor L. Barsukov, "Structural variability of the ubiquitin specific protease DUSP-UBL double domains", Febs Letters (2011), DOI: 10.1016/j.febslet.2011.09.040
- Zhenbo Cao, Timothy J. Tavender, Aleksander W. Roszak, Richard J. Cogdell, Neil J. Bulleid, "Crystal structure of reduced and of oxidized peroxiredoxin IV reveals a stable oxidized decamer and a non disulfide-bonded intermediate in the catalytic cycle", Journal Of Biological Chemistry (2011), DOI: 10.1074/jbc.M111.298810
- [Conference Paper] J. P. Sutter, S. Alcock, K. Sawhney, "Ex situ and in situ methods of inspecting and optimizing adaptive bimorph mirrors", Diamond Light Source Proceedings, 1 (2011), DOI: 10.1017/S2044820110000225
- Paula S. Salgado, Robert Yan, Jonathan D. Taylor, Lynne Buchnell, Rhian Jones, Lois L. Hoyer, Steve J. Matthews, Peter J. Simpson, Ernesto Cota, "Structural basis for the broad tissue tropism of the pathogenic fungus Candida Albicans", Proceedings Of The National Academy Of Sciences (2011), DOI: 10.1073/pnas.1103496108
- Charlotte Hodson, Ambrose R. Cole, Laurence P. C. Lewis, Jennifer A. Miles, Andrew Purkiss, Helen Walden, "Structural analysis of human FANCL, the E3 ligase in the fanconi anemia pathway", Journal Of Biological Chemistry, 286 (37), 32628 - 32637 (2011), DOI: 10.1074/jbc.M111.244632
- Nien-Jen Hu, So Iwata, Alexander D. Cameron, David Drew, "Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT", Nature (2011), DOI: 10.1038/nature10450
- Daniel A. East, Duncan Sousa, Stephen R. Martin, Thomas A. Edwards, William Lehman, Daniel P. Mulvihill, "Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin", Biochemical Journal, 438 (2), 265 - 273 (2011), DOI: 10.1042/BJ20101316
- Yoshikazu Kawai, Jon Marles-Wright, Robert M. Cleverley, Robyn Emmins, Shu Ishikawa, Masayoshi Kuwano, Nadja Heinz, Nhat Khai Bui, Christopher N. Hoyland, Naotake Ogasawara, Rick Lewis, Waldemar Vollmer, Richard A. Daniel, Jeff Errington, "A widespread family of bacterial cell wall assembly proteins", The Embo Journal (2011), DOI: 10.1038/emboj.2011.358
- [Book Chapter] Muhammad Saleem, Jeremy Moore, Jeremy Derrick, "Expression, purification and crystallization of Neisserial outer membrane proteins" (2011), DOI: 10.1007/978-1-61779-346-2_6
- Susana Goncalves, Ana M. Esteves, Helena Santos, Nuno Borges, Pedro M. Matias, "The three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27: a new member of the Haloalkanoic Acid Dehalogenase superfamily", Biochemistry (2011), DOI: 10.1021/bi201171h
- Emília Antolikova, Lenka Zakova, Johan P. Turkenburg, Christopher J. Watson, Ivona Hanclova, Miloslav Sanda, Alan Cooper, Tomas Kraus, A. Marek Brzozowski, Jiri Jiracek, "Non-equivalent role of inter- and intra-molecular hydrogen bonds in the insulin dimer interface", Journal Of Biological Chemistry (2011), DOI: 10.1074/jbc.M111.265249
- Karl Syson, Clare E. M. Stevenson, Martin Rejzek, Shirley A. Fairhurst, Alap Nair, Celia J. Bruton, Robert A. Field, Keith F. Chater, Stephen Bornemann, David M. Lawson, "Structure of a Streptomyces maltosyltransferase GlgE: a homologue of a genetically validated anti-tuberculosis target", Journal Of Biological Chemistry (2011), DOI: 10.1074/jbc.M111.279315
- [Thesis] Falah Sumoon Daghal Al-Fartusie, "Engineering and characterisation of novel protein covalent linkages in horseradish peroxidase (HRP) : effect on structure and function" (2011)
- D. Corti, J. Voss, S. J. Gamblin, G. Codoni, A. Macagno, D. Jarrossay, S. G. Vachieri, D. Pinna, A. Minola, F. Vanzetta, C. Silacci, B. M. Fernandez-Rodriguez, G. Agatic, S. Bianchi, I. Giacchetto-Sasselli, L. Calder, F. Sallusto, Patrick Collins, L. F. Haire, N. Temperton, J. P. M. Langedijk, John J. Skehel, A. Lanzavecchia, "A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 Influenza a hemagglutinins", Science, 333, 850 - 856 (2011), DOI: 10.1126/science.1205669
- Janet E Deane, Stephen Graham, Nee Na Kim, Penelope E. Stein, R. Mcnair, M. B. Cachon-Gonzalez, T. M. Cox, Randy Read, "Insights into Krabbe disease from structures of galactocerebrosidase", Proceedings Of The National Academy Of Sciences (2011), DOI: 10.1073/pnas.1105639108
- Vicki L. Colledge, Mark J. Fogg, Vladimir M. Levdikov, Andrew Leech, Eleanor J. Dodson, Anthony J. Wilkinson, "Structure and organisation of SinR, the master regulator of biofilm formation in Bacillus subtilis", Journal Of Molecular Biology, 411 (3), 597 - 613 (2011), DOI: 10.1016/j.jmb.2011.06.004
- Tung B. K. Le, Maria A. Schumacher, Rcihard G. Brennan, Mark J. Buttner, David M. Lawson, "The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding", Nucleic Acids Research (2011), DOI: 10.1093/nar/gkr640
- Hugh P. Morgan, Jingzi Jiang, Andrew P. Herbert, David Kavanagh, Dušan Uhrin, Paul N. Barlow, Jonathan P. Hannan, "Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H", Acta Crystallographica Section D Biological Crystallography, 67 (7), 593 - 600 (2011), DOI: 10.1107/S0907444911015423
- Sigrid Egger, Apirat Chaikuad, Kathryn L. Kavanagh, Udo Oppermann, Bernd Nidetzky, "Structure and mechanism of human UDP-glucose 6-dehydrogenase", Journal Of Biological Chemistry, 286 (27), 23877-23887. (2011), DOI: 10.1074/jbc.M111.234682
- Hugh P. Morgan, Iain W. Mcnae, Matthew W. Nowicki, Wenhe Zhong, Paul A. M. Michels, Douglas S. Auld, Linda A. Fothergill-Gilmore, Malcolm D. Walkinshaw, "The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site", Journal Of Biological Chemistry, 286 (36), 31232 - 31240 (2011), DOI: 10.1074/jbc.M110.212613
- E. A. Clark, N. Walker, D. C. Ford, I. A. Cooper, P. C. F. Oyston, K. R. Acharya, "Molecular recognition of chymotrypsin by the serine protease inhibitor ecotin from Yersinia pestis", Journal Of Biological Chemistry, 286 (27), 24015 - 24022 (2011), DOI: 10.1074/jbc.M111.225730
- Miriam Walden, Huw Jenkins, Thomas Edwards, "Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 Å resolution", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (7), 744 - 748 (2011), DOI: 10.1107/S1744309111017453
- Stephen Hare, Steven J. Smith, Mathieu Metifiot, Albert Jaxa-Chamiec, Yves Pommier, Stephen H. Hughes, Peter Cherepanov, "Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572)", Molecular Pharmacology (2011), DOI: 10.1124/mol.111.073189
- Stefan H. Millson, Chun-Song Chua, S. Mark Roe, Sigrun Polier, Svetlana Solovieva, Laurence H. Pearl, Tiow-Suan Sim, Chrisostomos Prodromou, Peter W. Piper, "Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90", The Faseb Journal (2011), DOI: 10.1096/fj.11-188821
- Karthik S. Paithankar, Henning O. Sørensen, Jonathan P. Wright, Søren Schmidt, Henning F. Poulsen, Elspeth F. Garman, "Simultaneous X-ray diffraction from multiple single crystals of macromolecules", Acta Crystallographica Section D Biological Crystallography, 67 (7), 608 - 618 (2011), DOI: 10.1107/S0907444911015617
- Stephane Mouilleron, Carola A. Langer, Sebastian Guettler, Neil Q. Mcdonald, Richard Treisman, "Structure of a pentavalent G-actin•MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator", Science Signaling, 4 (177), ra40 - ra40 (2011), DOI: 10.1126/scisignal.2001750
- Li Zhang, Louise Fairall, Benjamin Goult, Anna C. Calkin, Cynthia Hong, Chris Millard, Peter Tontonoz, John W. R. Schwabe, "The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor", Genes & Development, 25 (12), 1262 - 1274 (2011), DOI: 10.1101/gad.2056211
- A. Kale, C. Phansopa, C. Suwannachart, C. J. Craven, J. B. Rafferty, D. J. Kelly, "The virulence factor PEB4 (Cj0596) and the periplasmic protein Cj1289 are two structurally related SurA-like chaperones in the human pathogen Campylobacter jejuni", Journal Of Biological Chemistry, 286 (24), 21254 - 21265 (2011), DOI: 10.1074/jbc.M111.220442
- [Conference Paper] Richard Cogdell, "Mapping lipid and detergent molecules at the surface of membrane proteins" (2011), DOI: 10.1042/BST0390775
- [Thesis] Gabriela Baeza, "X-ray crystallographic structure of the murine norovirus protease at 1.66 Å resolution and functional studies of the β-ribbon" (2011)
- [Thesis] Jenna Bailey, "Complementary structural studies of C-reactive protein complexed with natural ligands" (2011)
- Isobel H. Norville, Katherine O'Shea, Mitali Sarkar‑tyson, Suxin Zheng, Richard W. Titball, Gabriele Varani, Nicholas J. Harmer, "The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development", Biochemical Journal, 437 (3), 413 - 422 (2011), DOI: 10.1042/BJ20110345
- G. Kochan, T. Krojer, D. Harvey, R. Fischer, L. Chen, M. Vollmar, F. Von Delft, K. Kavanagh, M. A. Brown, P. Bowness, P. Wordsworth, B. M. Kessler, U. Oppermann, "Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming", Proceedings Of The National Academy Of Sciences, 108 (19), 7745 - 7750 (2011), DOI: 10.1073/pnas.1101262108
- Tobias Krojer, Frank Von Delft, "Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects", Journal Of Synchrotron Radiation, 18 (3), 387-397 (2011), DOI: 10.1107/S0909049511008235
- Eidarus Salah, Emilie Ugochukwu, Alastair J. Barr, Frank Von Delft, Stefan Knapp, Jonathan M. Elkins, "Crystal structures of ABL-related gene (ABL2) in Complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class", Journal Of Medicinal Chemistry, 54 (7), 2359 - 2367 (2011), DOI: 10.1021/jm101506n
- Geoffrey Masuyer, Matthew Beard, Verity Cadd, John Chaddock, K. Ravi Acharya, "Structure and activity of a functional derivative of Clostridium botulinum neurotoxin", Journal Of Structural Biology, 174 (1), 52-57 (2011), DOI: 10.1016/j.jsb.2010.11.010
- Paula S. Salgado, Robert Yan, Fiona Rowan, Ernesto Cota, "Expression, crystallization and preliminary X-ray data analysis of NT-ALS9, a fungal adhesin from Candida albicans", Acta Crystallographica Section F Structural Biology And Crystallization Communications (2011), DOI: 10.1107/S1744309111003460
- Pawel Sledz, Christopher J. Stubbs, Steffen Lang, Yong-Qing Yang, Grahame J. Mckenzie, Ashok R. Venkitaraman, Marko Hyvonen, Chris Abell, "From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1", Angewandte Chemie International Edition, 50 (17), 4003 - 4006 (2011), DOI: 10.1002/anie.201008019
- Thomas A. Edwards, Andrew J. Wilson, "Helix-mediated protein-protein interactions as targets for intervention using foldamers", Amino Acids (2011), DOI: 10.1007/s00726-011-0880-8
- Bing Xiao, Matthew J. Sanders, Elizabeth Underwood, Richard Heath, Faith V. Mayer, David Carmena, Chun Jing, Phil Walker, John F. Eccleston, Lesley F. Haire, Peter Saiu, Steven A. Howell, Rein Aasland, Stephen R. Martin, David Carling, Steven Gamblin, "Structure of mammalian AMPK and its regulation by ADP", Nature, 472, 230 - 233 (2011), DOI: 10.1038/nature09932
- Peter Daldrop, Francis Reyes, David Robinson, Colin M. Hammond, David M. Lilley, Robert Batey, Ruth Brenk, "Novel ligands for a purine riboswitch discovered by RNA-ligand docking", Chemistry - A European Journal, 18 (3) (2011), DOI: 10.1016/j.chembiol.2010.12.020
- Madhav Sukumaran, Maxim Rossmann, Indira Shrivastava, Anindita Dutta, Ivet Bahar, Ingo H. Greger, "Dynamics and allosteric potential of the AMPA receptor N-terminal domain", The Embo Journal, 30 (5), 972-982 (2011), DOI: 10.1038/emboj.2011.17
- Maxim Rossmann, Madhav Sukumaran, Andrew C. Penn, Dmitry B. Veprintsev, M. Madan Babu, Ingo H. Greger, "Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers", The Embo Journal, 30 (5), 959-971 (2011), DOI: 10.1038/emboj.2011.16
- Apirat Chaikuad, Naeem Shafqat, Ruby Al-Mokhtar, Gus Cameron, Anthony R. Clarke, R. Leo Brady, Udo Oppermann, Jan Frayne, Wyatt W. Yue, "Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS", Biochemical Journal, 435 (2), 401-409 (2011), DOI: 10.1042/BJ20101442
- Christiane Riedinger, Martin Noble, David J. Wright, Florian Mulks, Ian R. Hardcastle, Jane A. Endicott, James M. Mcdonnell , "Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy", Chemical Biology And Drug Design (2011), DOI: 10.1111/j.1747-0285.2011.01091.x
- Savade Solanki, Paolo Innocenti, Corine Mas-Droux, Kathy Boxall, Caterina Barillari, Rob L. M. Van Montfort, G. Wynne Aherne, Richard Bayliss, Swen Hoelder, "Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship", Journal Of Medicinal Chemistry, 54 (6), 1626 - 1639 (2011), DOI: 10.1021/jm1011726
- Tung B. K. Le, Clare E. M. Stevenson, Mark J. Buttner, David M. Lawson, "Crystallization and preliminary X-ray analysis of the TetR-like efflux pump regulator SimR", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (3), 307-309 (2011), DOI: 10.1107/S1744309110053078
- Naushaba Nayeem, Olga Mayans, Tim Green, "Conformational flexibility of the ligand-binding domain dimer in kainate receptor gating and desensitization", Journal Of Neuroscience, 31 (8), 2916-2924 (2011), DOI: 10.1523/JNEUROSCI.4771-10.2011
- Andrew J. Fielding, Elena G. Kovaleva, Erik R. Farquhar, John D. Lipscomb, Laurence Que, Jr., "A hyperactive cobalt-substituted extradiol-cleaving catechol dioxygenase", Journal Of Biological Chemistry, 16 (2), 341-355 (2011), DOI: 10.1007/s00775-010-0732-0
- Mohd Akif, Sylva L. Schwager, Colin S. Anthony, Bertrand Czarny, Fabrice Beau, Edward Sturrock, K. Ravi Acharya, "Novel mechanism of inhibition of human Angiotensin-I converting enzyme (ACE) by a highly specific phosphinic tripeptide", Biochemical Journal (2011), DOI: 10.1042/BJ20102123
- Tung B. K. Le, Clare E. M. Stevenson, Hans-Peter Fiedler, Anthony Maxwell, David M. Lawson, Mark J. Buttner, "Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression", Journal Of Molecular Biology (2011), DOI: 10.1016/j.jmb.2011.02.035
- Morten Nielsen, Michael Suits, Min Yang, Conor Barry, Carlos Martinez-Fleites, Louise Tailford, James Flint, Claire Dumon, Benjamin Davis, Harry Gilbert, Gideon Davies, "Substrate and metal-ion promiscuity in mannosylglycerate synthase", Journal Of Biological Chemistry (2011), DOI: 10.1074/jbc.M110.199844
- Hung Yi Kristal Kaan, Johanna Weiss, Dominik Menger, Venkatasubramanian Ulaganathan, Katarzyna Tkocz, Christian Laggner, Florence Popowycz, Benoit Joseph, Frank Kozielski, "Structure−activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5", Journal Of Medicinal Chemistry, 54 (6) (2011), DOI: 10.1021/jm100991m
- A. R. Clark, C. E. Naylor, C. Bagneris, N. H. Keep, C. Slingsby, "Crystal structure of R120G disease mutant of human αB-crystallin domain dimer shows closure of a groove", Journal Of Molecular Biology, 408 (1), 118-134 (2011), DOI: 10.1016/j.jmb.2011.02.020
- Michael Gamble, Georg Kunze, Eleanor J. Dodson, Keith S. Wilson, D. Dafydd Jones, "Regulation of an intracellular subtilisin protease activity by a short propeptide sequence through an original combined dual mechanism", Proceedings Of The National Academy Of Sciences (2011), DOI: 10.1073/pnas.1014229108
- Hugh P. Morgan, Christoph Q. Schmidt, Mara Guariento, Bärbel S. Blaum, Dominic Gillespie, Andrew P. Herbert, David Kavanagh, Haydyn D. T. Mertens, Dmitri I. Svergun, Conny M. Johansson, Dušan Uhrín, Paul N. Barlow, Jonathan P. Hannan, "Structural basis for engagement by complement factor H of C3b on a self surface", Nature Structural & Molecular Biology, 18 (4), 463 - 470 (2011), DOI: 10.1038/nsmb.2018
- Maruf M. U. Ali, Tina Bagratuni, Emma L. Davenport, Piotr R. Nowak, M. Cris Silva-Santisteban, Anthea Hardcastle, Craig Mcandrews, Martin G. Rowlands, Gareth J. Morgan, Wynne Aherne, Ian Collins, Faith E. Davies, Laurence H. Pearl, "Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response", The Embo Journal, 30 (5), 894 - 905 (2011), DOI: 10.1038/emboj.2011.18
- Hassan G. Choudhury, Alexander D. Cameron, So Iwata, Konstantinos Beis, "Structure and mechanism of the chalcogen detoxifying protein TehB from Escherichia coli", Biochemical Journal (2011), DOI: 10.1042/BJ20102014
- Kutti R. Vinothkumar, "Structure of rhomboid protease in a lipid environment", Journal Of Molecular Biology (2011), DOI: 10.1016/j.jmb.2011.01.029
- Xun Cai, Rui Wang, Alain Filloux, Gabriel Waksman, Goyu Meng, "Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones", Plos One (2011), DOI: 10.1371/journal.pone.0016583
- Philip Simister, Nick Burton, Leo Brady, "Phosphotyrosine recognition by the Raf kinase inhibitor protein", Onco Therapeutics, 2(1), 59-70 (2011), DOI: 10.1615/ForumImmunDisTher.v2.i1.70
- Svetlana Antonyuk, Mike Hough, "Monitoring and validating active site redox states in protein crystals", Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics (2011), DOI: 10.1016/j.bbapap.2010.12.017
- [Conference Paper] Pietro Roversi, Steven Johnson, "The structure of human complement factor I" (2011)
- Jasmeen Oberoi, Louise Fairall, Peter J. Watson, Ji-Chun Yang, Zsolt Czimmerer, Thorsten Kampmann, Ben Goult, Jacquie Greenwood, John T. Gooch, Bettina C. Kallenburger, Laszlo Nagy, David Neuhaus, John W. R. Schwabe, "Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery", Nature Structural & Molecular Biology, 18 (2), 177 - 184 (2011), DOI: 10.1038/nsmb.1983
- John J. Caldwell, Emma J. Welsh, Cornelis Matijssen, Victoria E. Anderson, Laurent Antoni, Kathy Boxall, Frederique Urban, Angela Hayes, Florence I. Raynaud, Laurent J. M. Rigoreau, Tony Raynham, G. Wynne Aherne, Laurence H. Pearl, Antony W. Oliver, Michelle D. Garrett, Ian Collins, "Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2", Journal Of Medicinal Chemistry, 54 (2), 580 - 590 (2011), DOI: 10.1021/jm101150b
- Simon Newstead , David Drew, Alexander D. Cameron, Vincent L. G. Postis, Xiaobing Xia, Philip W. Fowler, Jean C. Ingram, Elisabeth P. Carpenter, Mark S. P. Sansom, Michael J. Mcpherson, Stephen A. Baldwin, So Iwata, "Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2.", The Embo Journal (2011), DOI: 10.1038/emboj.2010.309
- Wen-Jun Gui, Shi-Qiang Lin, Yuan-Yuan Chen, Xian-En Zhang, Li-Jun Bi, Tao Jiang, "Crystal structure of DNA polymerase III β sliding clamp from Mycobacterium tuberculosis", Biochemical And Biophysical Research Communications (2011), DOI: 10.1016/j.bbrc.2011.01.027
- Xiaoli Xiong, Elizabeth H. C. Bromley, Peter Oelschlaeger, Derek N. Woolfson, James Spencer, "Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium", Nucleic Acids Research, 39 (1), 3917-3927 (2011), DOI: 10.1093/nar/gkq1296
- Dawei Chen, Melanie Vollmar, Marianna N. Rossi, Claire Phillips, Rolf Kraehenbuehl, Dea Slade, Pawan V. Mehrotra, Frank Von Delft, Susan K. Crosthwaite, Opher Gileadi, John M. Denu, Ivan Ahel, "Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases", Journal Of Biological Chemistry, 286 (15), 13261-13271 (2011), DOI: 10.1074/jbc.M110.206771
- Paula Salgado, Jonathan Taylor, Ernesto Cota, Steve J. Matthews, "Extending the usability of the phasing power of diselenide bonds: SeCys SAD phasing of CsgC using a non-auxotrophic strain", Acta Crystallographica Section D, 67, 8-13 (2011), DOI: 10.1107/S0907444910042022
- Tim R. Blower, Xue-Yuan Pei, Francesca L. Short, Peter C. Fineran, David P. Humphreys, Ben F. Luisi, George P. C. Salmond, "A processed noncoding RNA regulates an altruistic bacterial antiviral system", Nature Structural & Molecular Biology, 18 (2), 185190 (2011), DOI: 10.1038/nsmb.1981
- T. Tanaka, H. Sewell, S. Waters, S. E. V. Phillips, T. H. Rabbitts, "Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain", Journal Of Biological Chemistry, 286 (5), 3707 - 3716 (2011), DOI: 10.1074/jbc.M110.188193
- Victoria E. Anderson, M. I. Walton, P. D. Eve, K. J. Boxall, L. Antoni, J. J. Caldwell, W. Aherne, L. H. Pearl, Antony W. Oliver, I. Collins, M. D. Garrett, "CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors", Cancer Research, 71 (2), 463 - 472 (2011), DOI: 10.1158/0008-5472.CAN-10-1252
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
Diamond Light Source Ltd
Diamond House
Harwell Science & Innovation Campus
Didcot
Oxfordshire
OX11 0DE
Copyright © Diamond Light Source. Diamond Light Source® and the Diamond logo are registered trademarks of Diamond Light Source Ltd
Registered in England and Wales at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom. Company number: 4375679. VAT number: 287 461 957. Economic Operators Registration and Identification (EORI) number: GB287461957003.