Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I03 Contact
Beamline Phone Number:
+44 (0) 1235 778707
Acting Principal Beamline Scientist:
Dave Hall
Tel: +44 (0) 1235 778926
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I03 MX
Status: Operational
Beamsize: 90 µm x 20 µm
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
These publications are based on data gathered on beamline I03. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
155 items found for 2018 [total: 2353]
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis Nature Chemical Biology, 15 Dec 2018 DOI: 10.1038/s41589-018-0185-2
Journal Paper I03-Macromolecular Crystallography
A protective monoclonal antibody targets a site of vulnerability on the surface of Rift Valley Fever Virus Cell Reports, 25 Dec 2018 DOI: 10.1016/j.celrep.2018.12.001
Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1 Nature Communications, 9 Dec 2018 DOI: 10.1038/s41467-018-07794-7
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry Biochemical Journal, Dec 2018 DOI: 10.1042/BCJ20180788
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Interactome rewiring following pharmacological targeting of BET bromodomains Molecular Cell, Dec 2018 DOI: 10.1016/j.molcel.2018.11.006
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps Journal Of Medicinal Chemistry, Dec 2018 DOI: 10.1021/acs.jmedchem.8b01292
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B~ubiquitin complex Journal Of Biological Chemistry, Dec 2018 DOI: 10.1074/jbc.RA118.006045
Identification of mineralocorticoid receptor modulators with low impact on electrolyte homeostasis but maintained organ protection Journal Of Medicinal Chemistry, Dec 2018 DOI: 10.1021/acs.jmedchem.8b01523
Journal Paper I03-Macromolecular Crystallography
Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii Elife, 7 Dec 2018 DOI: 10.7554/eLife.42270
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Discovery of potent, efficient, and selective inhibitors of phosphoinositide 3-kinase δ through a deconstruction and regrowth approach Journal Of Medicinal Chemistry, 61 Dec 2018 DOI: 10.1021/acs.jmedchem.8b01556
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
A Rieske oxygenase/epoxide hydrolase-catalysed reaction cascade creates oxygen heterocycles in mupirocin biosynthesis Nature Catalysis, 1 Dec 2018 DOI: 10.1038/s41929-018-0183-5
Journal Paper I03-Macromolecular Crystallography
A multidisciplinary approach toward identification of antibiotic scaffolds for Acinetobacter baumannii Structure, Dec 2018 DOI: 10.1016/j.str.2018.10.021
Journal Paper I03-Macromolecular Crystallography
Bulk changes in posterior scleral collagen microstructure in human high myopia Molecular Vision, 24 Dec 2018
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography
A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation Nature Microbiology, 130 Nov 2018 DOI: 10.1038/s41564-018-0271-y
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural insights into the function of type VI secretion system TssA subunits Nature Communications, 9 Nov 2018 DOI: 10.1038/s41467-018-07247-1
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition Nucleic Acids Research, 1 Nov 2018 DOI: 10.1093/nar/gky1181
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Computational design of epitope-specific functional antibodies Cell Reports, 25 Nov 2018 DOI: 10.1016/j.celrep.2018.10.081
The structure of PghL hydrolase bound to its substrate poly-γ-glutamate The Febs Journal, Nov 2018 DOI: 10.1111/febs.14688
Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition Cell Chemical Biology, Nov 2018 DOI: 10.1016/j.chembiol.2018.10.015
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Novel fluorescence competition assay for retinoic acid binding proteins Acs Medicinal Chemistry Letters, Nov 2018 DOI: 10.1021/acsmedchemlett.8b00420
A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase Nature Structural & Molecular Biology, 434 Nov 2018 DOI: 10.1038/s41594-018-0152-3
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
(ADP-ribosyl)hydrolases: structural basis for differential substrate recognition and inhibition Cell Chemical Biology, Nov 2018 DOI: 10.1016/j.chembiol.2018.11.001
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural characterisation of calnexin cycle components and assessment as antiviral targets Nov 2018
Thesis I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
New irreversible α- l -Iduronidase inhibitors and activity-based probes Chemistry - A European Journal, 42 Nov 2018 DOI: 10.1002/chem.201804662
The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs Nucleic Acids Research, Nov 2018 DOI: 10.1093/nar/gky1187
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly Iucrj, 5 Nov 2018 DOI: 10.1107/S2052252518012459
Maintaining and breaking symmetry in homomeric coiled-coil assemblies Nature Communications, 9 Oct 2018 DOI: 10.1038/s41467-018-06391-y
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells Cell, Oct 2018 DOI: 10.1016/j.cell.2018.08.033
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Cotranslational folding of a pentarepeat β-helix protein Journal Of Molecular Biology, Oct 2018 DOI: 10.1016/j.jmb.2018.10.016
Journal Paper I03-Macromolecular Crystallography
Pathological macromolecular crystallographic data affected by twinning, partial-disorder and exhibiting multiple lattices for testing of data processing and refinement tools Scientific Reports, 8 Oct 2018 DOI: 10.1038/s41598-018-32962-6
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
The molecular basis of protein toxin HicA–dependent binding of the protein antitoxin HicB to DNA Journal Of Biological Chemistry, Oct 2018 DOI: 10.1074/jbc.RA118.005173
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Non-equivalence of second sphere ‘non-catalytic’ residues in pentaerythritol tetranitrate reductase in relation to local dynamics linked to H-transfer in reactions with NADH and NADPH coenzymes Acs Catalysis, Oct 2018 DOI: 10.1021/acscatal.8b02810
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A mechanism for reductive amination catalyzed by fungal reductive aminases (RedAms) Acs Catalysis, Oct 2018 DOI: 10.1021/acscatal.8b03491
New thermophilic α/β class epoxide hydrolases found in metagenomes from hot environments Frontiers In Bioengineering And Biotechnology, 6 Oct 2018 DOI: 10.3389/fbioe.2018.00144
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Molecular basis for multiple omapatrilat binding sites within the ACE C-domain: implications for drug design Journal Of Medicinal Chemistry, Oct 2018 DOI: 10.1021/acs.jmedchem.8b01309
Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo -xyloglucanases Organic & Biomolecular Chemistry, 5 Oct 2018 DOI: 10.1039/C8OB02250J
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
The X-ray structure of human calbindin-D28K: an improved model Acta Crystallographica Section D Structural Biology, 74 Oct 2018 DOI: 10.1107/S2059798318011610
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I23-Long wavelength MX open access
The role of RNA structure in translational regulation by L7Ae protein in archaea Rna, Oct 2018 DOI: 10.1261/rna.068510.118
Structural basis for DNA break recognition by ARTD2/PARP2 Nucleic Acids Research, 7 Oct 2018 DOI: 10.1093/nar/gky927
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis Nature, 441 Oct 2018 DOI: 10.1038/s41586-018-0644-7
Identification of the site of oxidase substrate binding in Scytalidium thermophilum catalase Acta Crystallographica Section D Structural Biology, 74 Oct 2018 DOI: 10.1107/S2059798318010628
The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK Developmental Cell, 47 Oct 2018 DOI: 10.1016/j.devcel.2018.08.012
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structure-based classification defines the discrete conformational classes adopted by the arenaviral GP1 Journal Of Virology, Oct 2018 DOI: 10.1128/JVI.01048-18
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I23-Long wavelength MX open access
Identification of quinoline-based RIP2 kinase inhibitors with an improved therapeutic index to the hERG ion channel Acs Medicinal Chemistry Letters, Sept 2018 DOI: 10.1021/acsmedchemlett.8b00344
Journal Paper I03-Macromolecular Crystallography
Sphingobacterium sp. T2 manganese superoxide dismutase catalyses the oxidative demethylation of polymeric lignin via generation of hydroxyl radical Acs Chemical Biology, Sept 2018 DOI: 10.1021/acschembio.8b00557
Journal Paper I03-Macromolecular Crystallography
Structural and mechanistic insights into the catalytic-domain-mediated short-range glycosylation preferences of galnac-t4 Acs Central Science, Sept 2018 DOI: 10.1021/acscentsci.8b00488
Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody Nature Communications, 9 Sept 2018 DOI: 10.1038/s41467-018-06340-9
TssA from Burkholderia cenocepacia : expression, purification, crystallization and crystallographic analysis Acta Crystallographica Section F Structural Biology Communications, 74 Sept 2018 DOI: 10.1107/S2053230X18009706
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Tannerella forsythia Tfo belongs to Porphyromonas gingivalis HmuY-like family of proteins but differs in heme-binding properties Bioscience Reports, Sept 2018 DOI: 10.1042/BSR20181325
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33 Acta Crystallographica Section D Structural Biology, 74 Sept 2018 DOI: 10.1107/S205979831800904X
Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1 Scientific Reports, 8 Sept 2018 DOI: 10.1038/s41598-018-31316-6
Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones Nature Communications, 9 Sept 2018 DOI: 10.1038/s41467-018-06192-3
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Paired refinement: Impact of reintegration and rescaling Sept 2018
Conference Paper I03-Macromolecular Crystallography
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface Nature Communications, 9 Sept 2018 DOI: 10.1038/s41467-018-06194-1
The broad aryl acid specificity of the amide bond synthetase McbA suggests potential for the biocatalytic synthesis of amides Angewandte Chemie International Edition, 57 Sept 2018 DOI: 10.1002/anie.201804592
Structural cycle of the Thermus thermophilus PilF ATPase: the powering of type IVa pilus assembly Scientific Reports, 8 Sept 2018 DOI: 10.1038/s41598-018-32218-3
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, Sept 2018 DOI: 10.1016/j.bbapap.2018.09.005
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A molecular hybridization approach for the design of potent, highly selective, and brain-penetrant n-myristoyltransferase inhibitors Journal Of Medicinal Chemistry, Sept 2018 DOI: 10.1021/acs.jmedchem.8b00884
TssA from Aeromonas hydrophila : expression, purification and crystallographic studies Acta Crystallographica Section F Structural Biology Communications, 74 Sept 2018 DOI: 10.1107/S2053230X18010439
Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB Mbio, 9 Sept 2018 DOI: 10.1128/mBio.01346-18
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt co-receptor LRP6 Febs Letters, Aug 2018 DOI: 10.1002/1873-3468.13212
Structure of the GH9 glucosidase/glucosaminidase from Vibrio cholerae Acta Crystallographica Section F Structural Biology Communications, 74 Aug 2018 DOI: 10.1107/S2053230X18011019
Novel quinazolinone inhibitors of ALK2 flip between alternate binding modes: Structure–activity relationship, structural characterization, kinase profiling, and cellular proof of concept Journal Of Medicinal Chemistry, Aug 2018 DOI: 10.1021/acs.jmedchem.8b00782
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Molecular recognition of a Thomsen-Friedenreich antigen mimetic targeting human galectin-3 Chemmedchem, Aug 2018 DOI: 10.1002/cmdc.201800525
Journal Paper I03-Macromolecular Crystallography
Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level Nature Communications, 9 Aug 2018 DOI: 10.1038/s41467-018-05702-7
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Redox-switchable siderophore anchor enables reversible artificial metalloenzyme assembly Nature Catalysis, 308 Aug 2018 DOI: 10.1038/s41929-018-0124-3
Design, synthesis and biological evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as dual inhibitors of discoidin domain receptor 1 and 2 (DDR1/2) Journal Of Medicinal Chemistry, Aug 2018 DOI: 10.1021/acs.jmedchem.8b01045
The BTK inhibitor ARQ 531 targets ibrutinib resistant CLL and Richter's transformation Cancer Discovery, Aug 2018 DOI: 10.1158/2159-8290.CD-17-1409
Journal Paper I03-Macromolecular Crystallography
Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment Nature Communications, 9 Aug 2018 DOI: 10.1038/s41467-018-05707-2
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase–dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance Journal Of Biological Chemistry, Aug 2018 DOI: 10.1074/jbc.RA118.004558
Structural basis of cross-reactivity of anti-citrullinated protein antibodies Arthritis & Rheumatology, Aug 2018 DOI: 10.1002/art.40698
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Reversible covalent direct thrombin inhibitors Plos One, 13 Aug 2018 DOI: 10.1371/journal.pone.0201377
Mechanistic exploitation of a self-repairing, blocked proton transfer pathway in an O2-tolerant [NiFe]-hydrogenase Journal Of The American Chemical Society, Aug 2018 DOI: 10.1021/jacs.8b04798
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structural basis for membrane tethering by a bacterial dynamin-like pair Nature Communications, 9 Aug 2018 DOI: 10.1038/s41467-018-05523-8
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) Krios I-Titan Krios I at Diamond Krios II-Titan Krios II at Diamond open access
A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds Science Advances, 4 Aug 2018 DOI: 10.1126/sciadv.aat2720
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Modified peptide inhibitors of the keap1-Nrf2 protein-protein interaction incorporating unnatural amino acids Chembiochem, 85 Jul 2018 DOI: 10.1002/cbic.201800170
An aspartate-specific solute-binding protein regulates protein kinase G activity to control glutamate metabolism in mycobacteria Mbio, 9 Jul 2018 DOI: 10.1128/mBio.00931-18
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A novel bacterial class V dye-decolourizing peroxidase from the extremophile Deinococcus radiodurans : cloning, expression optimization, purification, crystallization, initial characterization and X-ray diffraction analysis Acta Crystallographica Section F Structural Biology Communications, 74 Jul 2018 DOI: 10.1107/S2053230X18008488
Journal Paper I03-Macromolecular Crystallography
Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism Biochemical Journal, Jul 2018 DOI: 10.1042/BCJ20180222
Journal Paper I03-Macromolecular Crystallography
Surface probing by fragment-based screening and computational methods identifies ligandable pockets on the von Hippel-Lindau (VHL) E3 ubiquitin ligase Journal Of Medicinal Chemistry, Jul 2018 DOI: 10.1021/acs.jmedchem.8b00842
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
van der Waals contact between nucleophile and transferring phosphorus is insufficient to achieve enzyme transition state architecture Acs Catalysis, Jul 2018 DOI: 10.1021/acscatal.8b01612
Polymorphic residues in rice NLRs expand binding and response to effectors of the blast pathogen Nature Plants, 354 Jul 2018 DOI: 10.1038/s41477-018-0194-x
Insights into bacterial lipoprotein trafficking from a structure of LolA bound to the LolC periplasmic domain Proceedings Of The National Academy Of Sciences, 8 Jul 2018 DOI: 10.1073/pnas.1806822115
Journal Paper I03-Macromolecular Crystallography
Identification of a tyrosine switch in copper-haem nitrite reductases Iucrj, 5 Jul 2018 DOI: 10.1107/S2052252518008242
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase Nature Communications, 9 Jul 2018 DOI: 10.1038/s41467-018-05005-x
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural characterisation of oligosaccharide recognition by surfactant protein D Jul 2018
Thesis I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
A new structural class of bacterial thioester domains reveals a slipknot topology Protein Science, Jul 2018 DOI: 10.1002/pro.3478
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials Plos One, 13 Jul 2018 DOI: 10.1371/journal.pone.0198827
X-ray crystal structures show DNA stacking advantage of terminal nitrile substitution in Ru-dppz complexes Chemistry - A European Journal, Jul 2018 DOI: 10.1002/chem.201803021
Ycf48 involved in the biogenesis of the oxygen-evolving photosystem II complex is a seven-bladed beta-propeller protein Proceedings Of The National Academy Of Sciences, 49 Jul 2018 DOI: 10.1073/pnas.1800609115
Hepatitis A virus capsid structure Cold Spring Harbor Perspectives In Medicine, Jul 2018 DOI: 10.1101/cshperspect.a031807
ASTX660, a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP, potently induces TNFα-dependent apoptosis in cancer cell lines and inhibits tumor growth Molecular Cancer Therapeutics, 17 Jul 2018 DOI: 10.1158/1535-7163.MCT-17-0848
Journal Paper I03-Macromolecular Crystallography
Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides reveals alternative binding modes for the same LPS Plos One, 13 June 2018 DOI: 10.1371/journal.pone.0199175
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Unravelling the relaxed specificity of laminaribiose phosphorylase from Paenibacillus sp. strain YM-1 towards mannose 1-phosphate Chembiochem, June 2018 DOI: 10.1002/cbic.201800260
3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation Journal Of The American Chemical Society, June 2018 DOI: 10.1021/jacs.8b05807
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
High resolution crystal structure of substrate-free human neprilysin Journal Of Structural Biology, June 2018 DOI: 10.1016/j.jsb.2018.06.004
Journal Paper I03-Macromolecular Crystallography
Structure and ligand binding of the SAM-V riboswitch Nucleic Acids Research, 78 June 2018 DOI: 10.1093/nar/gky520
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
The FapF amyloid secretion transporter possesses an atypical asymmetric coiled coil Journal Of Molecular Biology, June 2018 DOI: 10.1016/j.jmb.2018.06.007
A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion Nature Communications, 9 June 2018 DOI: 10.1038/s41467-018-04878-2
Structural mechanism of AadA, a dual specificity aminoglycoside adenyl transferase from Salmonella enterica Journal Of Biological Chemistry, June 2018 DOI: 10.1074/jbc.RA118.003989
Cryo-EM shows how dynactin recruits two dyneins for faster movement Nature, 554 June 2018 DOI: 10.1038/nature25462
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines European Journal Of Medicinal Chemistry, 152 May 2018 DOI: 10.1016/j.ejmech.2018.04.035
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Type II secretion-dependent aminopeptidase LapA and acyltransferase PlaC are redundant for nutrient acquisition during Legionella pneumophila intracellular infection of amoebas Mbio, 9 May 2018 DOI: 10.1128/mBio.00528-18
Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif Acta Crystallographica Section D Structural Biology, 74 May 2018 DOI: 10.1107/S2059798318002942
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype Plos One, 13 May 2018 DOI: 10.1371/journal.pone.0196761
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Specific stereoisomeric conformations determine the drug potency of cladosporin scaffold against malarial parasite Journal Of Medicinal Chemistry, May 2018 DOI: 10.1021/acs.jmedchem.8b00565
Journal Paper I03-Macromolecular Crystallography
Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig Plos Pathogens, 14 May 2018 DOI: 10.1371/journal.ppat.1007017
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors Molecules, 23 May 2018 DOI: 10.3390/molecules23051221
X-ray crystal structures of the type IVb secretion system DotB ATPases Protein Science, May 2018 DOI: 10.1002/pro.3439
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Disease-associated mutations in CEP120 destabilize the protein and impair ciliogenesis Cell Reports, 23 May 2018 DOI: 10.1016/j.celrep.2018.04.100
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Development, optimization and structure–activity relationships of covalent-reversible JAK3 inhibitors based on a tricyclic imidazo[5,4-d]pyrrolo[2,3-b]pyridine scaffold Journal Of Medicinal Chemistry, May 2018 DOI: 10.1021/acs.jmedchem.8b00571
Journal Paper I03-Macromolecular Crystallography
Structural dynamics and catalytic properties of a multi-modular xanthanase Acs Catalysis, May 2018 DOI: 10.1021/acscatal.8b00666
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor Biochemical Journal, May 2018 DOI: 10.1042/BCJ20180171
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
The proteins that bind May 2018
Science Highlight I03-Macromolecular Crystallography
Targeting a subpocket in Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) enables the structure-based discovery of selective inhibitors with trypanocidal activity Journal Of Medicinal Chemistry, Apr 2018 DOI: 10.1021/acs.jmedchem.7b01670
Design and characterisation of tool inhibitors of DNA damage response proteins Apr 2018
Thesis I03-Macromolecular Crystallography
Structure and function of the type III pullulan hydrolase from Thermococcus kodakarensis Acta Crystallographica Section D Structural Biology, 74 Apr 2018 DOI: 10.1107/S2059798318001754
Journal Paper I03-Macromolecular Crystallography
Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex Febs Letters, Apr 2018 DOI: 10.1002/1873-3468.13074
Structural basis for the initiation of glycosaminoglycan biosynthesis by human xylosyltransferase 1 Structure, Apr 2018 DOI: 10.1016/j.str.2018.03.014
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding Journal Of Biological Chemistry, Apr 2018 DOI: 10.1074/jbc.RA118.002291
Unusual constriction zones in the major porins OmpU and OmpT from Vibrio cholerae Structure, Apr 2018 DOI: 10.1016/j.str.2018.03.010
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Biochemical and structural characterisation of human phosphatidylinositol transfer protein Nir2 and American hookworm lipid binding protein Na-FAR-1 Apr 2018
Thesis I03-Macromolecular Crystallography
Characterization and engineering of a plastic-degrading aromatic polyesterase Proceedings Of The National Academy Of Sciences, 39 Apr 2018 DOI: 10.1073/pnas.1718804115
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I23-Long wavelength MX open access
In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility Frontiers In Immunology, 9 Apr 2018 DOI: 10.3389/fimmu.2018.00674
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
The mechanism of acetyl transfer catalyzed by Mycobacterium tuberculosis GlmU Biochemistry, Apr 2018 DOI: 10.1021/acs.biochem.8b00121
X-ray and cryo-EM structures of inhibitor-bound cytochrome bc 1 complexes for structure-based drug discovery Iucrj, 5 Mar 2018 DOI: 10.1107/S2052252518001616
Structural basis for the role of serine-rich repeat proteins from Lactobacillus reuteri in gut microbe–host interactions Proceedings Of The National Academy Of Sciences, 404 Mar 2018 DOI: 10.1073/pnas.1715016115
Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix The Embo Journal, Mar 2018 DOI: 10.15252/embj.201797902
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structural and functional characterisation of multi-copper oxidase CueO from lignin-degrading bacterium Ochrobactrum sp. reveal its activity towards lignin model compounds and lignosulfonate The Febs Journal, 27 Mar 2018 DOI: 10.1111/febs.14437
Journal Paper I03-Macromolecular Crystallography
Targeting ligandable pockets on PHD zinc finger domains by a fragment-based approach Acs Chemical Biology, Mar 2018 DOI: 10.1021/acschembio.7b01093
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
The structure of hydrogenase-2 from Escherichia coli: implications for H2-driven proton pumping Biochemical Journal, Mar 2018 DOI: 10.1042/BCJ20180053
Journal Paper I03-Macromolecular Crystallography
A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance Nucleic Acids Research, 16 Mar 2018 DOI: 10.1093/nar/gky181
Biocatalytic routes to lactone monomers for polymer production Biochemistry, Mar 2018 DOI: 10.1021/acs.biochem.8b00169
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction Nature Communications, 9 Mar 2018 DOI: 10.1038/s41467-018-03460-0
Gluco-1H-imidazole: a new class of azole-type β-glucosidase inhibitor Journal Of The American Chemical Society, Mar 2018 DOI: 10.1021/jacs.8b02399
Structural studies of DNA-binding metal complexes of therapeutic importance Mar 2018
Book Chapter I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
JMJD5 is a human arginyl C-3 hydroxylase Nature Communications, 9 Mar 2018 DOI: 10.1038/s41467-018-03410-w
High resolution crystal structures of the receptor-binding domain of Clostridium botulinum neurotoxin serotypes A and FA Peerj, 6 Mar 2018 DOI: 10.7717/peerj.4552
A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets Nature Communications, 9 Feb 2018 DOI: 10.1038/s41467-018-03182-3
High-throughput kinetic analysis for target-directed covalent ligand discovery Angewandte Chemie International Edition, Feb 2018 DOI: 10.1002/anie.201711825
Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation Nature Communications, 9 Feb 2018 DOI: 10.1038/s41467-017-02811-7
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA Chemmedchem, Feb 2018 DOI: 10.1002/cmdc.201700774
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
In vitro and in vivo characterization of three Cellvibrio japonicus glycoside hydrolase family 5 members reveals potent xyloglucan backbone-cleaving functions Biotechnology For Biofuels, 11 Feb 2018 DOI: 10.1186/s13068-018-1039-6
Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE: a molecular basis for domain-selectivity The Febs Journal, Feb 2018 DOI: 10.1111/febs.14421
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Second-generation CK2α inhibitors targeting the αD pocket Chemical Science, 9 Feb 2018 DOI: 10.1039/C7SC05122K
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Engineering the “missing link” in biosynthetic (−)-menthol production: bacterial isopulegone isomerase Acs Catalysis, Jan 2018 DOI: 10.1021/acscatal.7b04115
The nature and reactivity of ferryl heme in compounds I and II Accounts Of Chemical Research, Jan 2018 DOI: 10.1021/acs.accounts.7b00463
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors Scientific Reports, 8 Jan 2018 DOI: 10.1038/s41598-018-19872-3
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structure of the C1r–C1s interaction of the C1 complex of complement activation Proceedings Of The National Academy Of Sciences, 265 Jan 2018 DOI: 10.1073/pnas.1718709115
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction Nature Communications, 9 Jan 2018 DOI: 10.1038/s41467-017-02312-7
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of the human myostatin precursor and determinants of growth factor latency The Embo Journal, Jan 2018 DOI: 10.15252/embj.201797883
Journal Paper I03-Macromolecular Crystallography
The structure of serum resistance-associated protein and its implications for human African trypanosomiasis Nature Microbiology, 75 Jan 2018 DOI: 10.1038/s41564-017-0085-3
Journal Paper I03-Macromolecular Crystallography
CDKL family kinases have evolved distinct structural features and ciliary function Cell Reports, 22 Jan 2018 DOI: 10.1016/j.celrep.2017.12.083
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Shielding and activation of a viral membrane fusion protein Nature Communications, 9 Jan 2018 DOI: 10.1038/s41467-017-02789-2
- Benjamin R. Lichman, Mohamed O. Kamileen, Gabriel R. Titchiner, Gerhard Saalbach, Clare E. M. Stevenson, David M. Lawson, Sarah E. O'Connor, "Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis", Nature Chemical Biology, 15, 71 - 79 (2018), DOI: 10.1038/s41589-018-0185-2
- Elizabeth R. Allen, Stefanie A. Krumm, Jayna Raghwani, Steinar Halldorsson, Angela Elliott, Victoria A. Graham, Elina Koudriakova, Karl Harlos, Daniel Wright, George M. Warimwe, Benjamin Brennan, Juha T. Huiskonen, Stuart D. Dowall, Richard M. Elliott, Oliver G. Pybus, Dennis R. Burton, Roger Hewson, Katie J. Doores, Thomas A. Bowden, "A protective monoclonal antibody targets a site of vulnerability on the surface of Rift Valley Fever Virus", Cell Reports, 25, 3750 - 3758.e4 (2018), DOI: 10.1016/j.celrep.2018.12.001
- James M. Dunce, Amy E. Milburn, Manickam Gurusaran, Irene Da Cruz, Lee T. Sen, Ricardo Benavente, Owen R. Davies, "Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-07794-7
- Tiila-Riikka Kiema, Chandan J. Thapa, Mikko Laitaoja, Werner Schmitz, Mirko M. Maksimainen, Toshiyuki Fukao, Juha Rouvinen, Janne Jänis, Rik K. Wierenga, "The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry", Biochemical Journal (2018), DOI: 10.1042/BCJ20180788
- Jean-Philippe Lambert, Sarah Picaud, Takao Fujisawa, Huayun Hou, Pavel Savitsky, Liis Uusküla-Reimand, Gagan D. Gupta, Hala Abdouni, Zhen-Yuan Lin, Monika Tucholska, James D. R. Knight, Beatriz Gonzalez-Badillo, Nicole St-Denis, Joseph A. Newman, Manuel Stucki, Laurence Pelletier, Nuno Bandeira, Michael D. Wilson, Panagis Filippakopoulos, Anne-Claude Gingras, "Interactome rewiring following pharmacological targeting of BET bromodomains", Molecular Cell (2018), DOI: 10.1016/j.molcel.2018.11.006
- Gydo C. P. Van Zundert, Brandi M. Hudson, Saulo H. P. De Oliveira, Daniel Keedy, Rasmus Fonseca, Amelie Heliou, Pooja Suresh, Kenneth Borrelli, Tyler Day, James Fraser, Henry Van Den Bedem, "qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b01292
- Amrita Patel, Gary J. Sibbet, Danny T. Huang, "Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B~ubiquitin complex", Journal Of Biological Chemistry (2018), DOI: 10.1074/jbc.RA118.006045
- Kenneth Granberg, Zhong-Qing Yuan, Bo Lindmark, Karl Edman, Johan Kajanus, Anders Hogner, Marcus Malmgren, Gavin O'Mahony, Anneli Nordqvist, Jan Lindberg, Stefan Tångefjord, Michael Kossenjans, Christian Löfberg, Jonas Brånalt, Dongmei Liu, Nidhal Selmi, Grigorios Nikitidis, Peter Nordberg, Ahlke Hayen, Anna Aagaard, Eva Hansson, Majlis Hermansson, Ida Ivarsson, Rasmus Jansson Löfmark, Ulla Karlsson, Ulrika Johansson, Lena William-Olsson, Judith Hartleib-Geschwindner, Krister Bamberg, "Identification of mineralocorticoid receptor modulators with low impact on electrolyte homeostasis but maintained organ protection", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b01523
- Lucile Moynie, Ilaria Serra, Mariano A. Scorciapino, Emilia Oueis, Malcolm G. P. Page, Matteo Ceccarelli, James Naismith, "Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii", Elife, 7 (2018), DOI: 10.7554/eLife.42270
- Nick Barton, Máire Convery, Anthony W. J. Cooper, Kenneth Down, J. Nicole Hamblin, Graham Inglis, Simon Peace, James Rowedder, Paul Rowland, Jonathan A. Taylor, Natalie Wellaway, "Discovery of potent, efficient, and selective inhibitors of phosphoinositide 3-kinase δ through a deconstruction and regrowth approach", Journal Of Medicinal Chemistry, 61, 11061 - 11073 (2018), DOI: 10.1021/acs.jmedchem.8b01556
- Luoyi Wang, Alice Parnell, Christopher Williams, Nurfarhanim A. Bakar, Martin R. Challand, Marc W. Van Der Kamp, Thomas J. Simpson, Paul R. Race, Matthew P. Crump, Christine L. Willis, "A Rieske oxygenase/epoxide hydrolase-catalysed reaction cascade creates oxygen heterocycles in mupirocin biosynthesis", Nature Catalysis, 1, 968 - 976 (2018), DOI: 10.1038/s41929-018-0183-5
- Satya Prathyusha Bhamidimarri, Michael Zahn, Jigneshkumar Dahyabhai Prajapati, Christian Schleberger, Sandra Söderholm, Jennifer Hoover, Josh West, Ulrich Kleinekathöfer, Dirk Bumann, Mathias Winterhalter, Bert Van Den Berg, "A multidisciplinary approach toward identification of antibiotic scaffolds for Acinetobacter baumannii", Structure (2018), DOI: 10.1016/j.str.2018.10.021
- Petar Markov, Ashkan Eliasy, Jacek K. Pijanka, Hla M. Htoon, Neil G. Paterson, Thomas Sorensen, Ahmed Elsheikh, Michael J.a. Girard, Craig Boote, "Bulk changes in posterior scleral collagen microstructure in human high myopia", Molecular Vision, 24, 818-833 (2018)
- Jonathan N. Pruneda, Robert J. Bastidas, Erithelgi Bertsoulaki, Kirby N. Swatek, Balaji Santhanam, Michael J. Clague, Raphael H. Valdivia, Sylvie Urbé, David Komander, "A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation", Nature Microbiology, 130 (2018), DOI: 10.1038/s41564-018-0271-y
- Samuel R. Dix, Hayley J. Owen, Ruyue Sun, Asma Ahmad, Sravanthi Shastri, Helena L. Spiewak, Daniel J. Mosby, Matthew J. Harris, Sarah L. Batters, Thomas A. Brooker, Svetomir B. Tzokov, Svetlana E. Sedelnikova, Patrick J. Baker, Per A. Bullough, David W. Rice, Mark S. Thomas, "Structural insights into the function of type VI secretion system TssA subunits", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-07247-1
- Richard B. Tunnicliffe, Colin Levy, Hilda D. Ruiz nivia, Rozanne M. Sandri-Goldin, Alexander P. Golovanov, "Structural identification of conserved RNA binding sites in herpesvirus ORF57 homologs: implications for PAN RNA recognition", Nucleic Acids Research, 1 (2018), DOI: 10.1093/nar/gky1181
- Guy Nimrod, Sharon Fischman, Mark Austin, Asael Herman, Feenagh Keyes, Olga Leiderman, David Hargreaves, Marek Strajbl, Jason Breed, Shelley Klompus, Kevin Minton, Jennifer Spooner, Andrew Buchanan, Tristan J. Vaughan, Yanay Ofran, "Computational design of epitope-specific functional antibodies", Cell Reports, 25, 2121 - 2131.e5 (2018), DOI: 10.1016/j.celrep.2018.10.081
- Sneha Ramaswamy, Masooma Rasheed, Carlo F. Morelli, Cinzia Calvio, Brian J. Sutton, Annalisa Pastore, "The structure of PghL hydrolase bound to its substrate poly-γ-glutamate", The Febs Journal (2018), DOI: 10.1111/febs.14688
- Daniel J. Wood, Svitlana Korolchuk, Natalie J. Tatum, Lan-Zhen Wang, Jane A. Endicott, Martin E. M. Noble, Mathew P. Martin, "Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition", Cell Chemical Biology (2018), DOI: 10.1016/j.chembiol.2018.10.015
- Charles W. E. Tomlinson, David R. Chisholm, Roy Valentine, Andrew Whiting, Ehmke Pohl, "Novel fluorescence competition assay for retinoic acid binding proteins", Acs Medicinal Chemistry Letters (2018), DOI: 10.1021/acsmedchemlett.8b00420
- Meghna Kataria, Stephane Mouilleron, Moon-Hyeong Seo, Carles Corbi-Verge, Philip M. Kim, Frank Uhlmann, "A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase", Nature Structural & Molecular Biology, 434 (2018), DOI: 10.1038/s41594-018-0152-3
- Johannes Gregor Matthias Rack, Antonio Ariza, Bryon S. Drown, Callum Henfrey, Edward Bartlett, Tomohiro Shirai, Paul J. Hergenrother, Ivan Ahel, "(ADP-ribosyl)hydrolases: structural basis for differential substrate recognition and inhibition", Cell Chemical Biology (2018), DOI: 10.1016/j.chembiol.2018.11.001
- [Thesis] Johan C. Hill, "Structural characterisation of calnexin cycle components and assessment as antiviral targets" (2018)
- Marta Artola, Chi-Lin Kuo, Stephen Mcmahon, Verena Oehler, Thomas Hansen, Martijn Van der lienden, Xu He, Hans Van den elst, Bogdan I. Florea, Allison R. Kermode, Gijsbert A. Van der marel, Tracey M. Gloster, Jeroen D. C. Codée, Herman S. Overkleeft, Johannes M. F. G. Aerts, "New irreversible α- l -Iduronidase inhibitors and activity-based probes", Chemistry - A European Journal, 42 (2018), DOI: 10.1002/chem.201804662
- Fabio Henrique Dos Santos Rodrigues, Helena Firczuk, Alexander L. Breeze, Alexander D. Cameron, Martin Walko, Nilson I. T. Zanchin, John E. G. Mccarthy, "The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs", Nucleic Acids Research (2018), DOI: 10.1093/nar/gky1187
- Patricia Casino, Roberto Gozalbo-Rovira, Jesús Rodríguez-Díaz, Sreedatta Banerjee, Ariel Boutaud, Vicente Rubio, Billy G. Hudson, Juan Saus, Javier Cervera, Alberto Marina, "Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly", Iucrj, 5 (2018), DOI: 10.1107/S2052252518012459
- Guto G. Rhys, Christopher W. Wood, Eric J. M. Lang, Adrian J. Mulholland, R. Leo Brady, Andrew R. Thomson, Derek N. Woolfson, "Maintaining and breaking symmetry in homomeric coiled-coil assemblies", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-06391-y
- Jaspreet Sandhu, Shiqian Li, Louise Fairall, Simon G. Pfisterer, Jennifer E. Gurnett, Xu Xiao, Thomas A. Weston, Dipti Vashi, Alessandra Ferrari, Jose L. Orozco, Celine L. Hartman, David Strugatsky, Stephen D. Lee, Cuiwen He, Cynthia Hong, Haibo Jiang, Laurent A. Bentolila, Alberto T. Gatta, Tim P. Levine, Annie Ferng, Richard Lee, David A. Ford, Stephen G. Young, Elina Ikonen, John Schwabe, Peter Tontonoz, "Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells", Cell (2018), DOI: 10.1016/j.cell.2018.08.033
- Luigi Notari, Markel Martinez-Carranza, Jose Arcadio Farias-Rico, Pal Stenmark, Gunnar Von Heijne, "Cotranslational folding of a pentarepeat β-helix protein", Journal Of Molecular Biology (2018), DOI: 10.1016/j.jmb.2018.10.016
- Ivan Campeotto, Andrey Lebedev, Antoine M. M. Schreurs, Louise Kroon-Batenburg, Edward Lowe, Simon E. V. Phillips, Garib N. Murshudov, Arwen R. Pearson, "Pathological macromolecular crystallographic data affected by twinning, partial-disorder and exhibiting multiple lattices for testing of data processing and refinement tools", Scientific Reports, 8 (2018), DOI: 10.1038/s41598-018-32962-6
- Ashley J. Winter, Christopher Williams, Michail N. Isupov, Hannah Crocker, Mariya Gromova, Philip Marsh, Oliver J. Wilkinson, Mark S. Dillingham, Nicholas J. Harmer, Richard W. Titball, Matthew P. Crump, "The molecular basis of protein toxin HicA–dependent binding of the protein antitoxin HicB to DNA", Journal Of Biological Chemistry (2018), DOI: 10.1074/jbc.RA118.005173
- Andreea I. Iorgu, Nicola J. Baxter, Matthew J. Cliff, Colin Levy, Jonathan P. Waltho, Sam Hay, Nigel S. Scrutton, "Non-equivalence of second sphere ‘non-catalytic’ residues in pentaerythritol tetranitrate reductase in relation to local dynamics linked to H-transfer in reactions with NADH and NADPH coenzymes", Acs Catalysis (2018), DOI: 10.1021/acscatal.8b02810
- Max O. Wiedorn, Dominik Oberthuer, Richard Bean, Robin Schubert, Nadine Werner, Brian Abbey, Martin Aepfelbacher, Luigi Adriano, Aschkan Allahgholi, Nasser Al-Qudami, Jakob Andreasson, Steve Aplin, Salah Awel, Kartik Ayyer, Saša Bajt, Imrich Barák, Sadia Bari, Johan Bielecki, Sabine Botha, Djelloul Boukhelef, Wolfgang Brehm, Sandor Brockhauser, Igor Cheviakov, Matthew A. Coleman, Francisco Cruz-Mazo, Cyril Danilevski, Connie Darmanin, R. Bruce Doak, Martin Domaracky, Katerina Dörner, Yang Du, Hans Fangohr, Holger Fleckenstein, Matthias Frank, Petra Fromme, Alfonso M. Gañán-Calvo, Yaroslav Gevorkov, Klaus Giewekemeyer, Helen Mary Ginn, Heinz Graafsma, Rita Graceffa, Dominic Greiffenberg, Lars Gumprecht, Peter Göttlicher, Janos Hajdu, Steffen Hauf, Michael Heymann, Susannah Holmes, Daniel A. Horke, Mark S. Hunter, Siegfried Imlau, Alexander Kaukher, Yoonhee Kim, Alexander Klyuev, Juraj Knoška, Bostjan Kobe, Manuela Kuhn, Christopher Kupitz, Jochen Küpper, Janine Mia Lahey-Rudolph, Torsten Laurus, Karoline Le Cong, Romain Letrun, P. Lourdu Xavier, Luis Maia, Filipe R. N. C. Maia, Valerio Mariani, Marc Messerschmidt, Markus Metz, Davide Mezza, Thomas Michelat, Grant Mills, Diana C. F. Monteiro, Andrew Morgan, Kerstin Mühlig, Anna Munke, Astrid Münnich, Julia Nette, Keith A. Nugent, Theresa Nuguid, Allen M. Orville, Suraj Pandey, Gisel Pena, Pablo Villanueva-Perez, Jennifer Poehlsen, Gianpietro Previtali, Lars Redecke, Winnie Maria Riekehr, Holger Rohde, Adam Round, Tatiana Safenreiter, Iosifina Sarrou, Tokushi Sato, Marius Schmidt, Bernd Schmitt, Robert Schönherr, Joachim Schulz, Jonas A. Sellberg, M. Marvin Seibert, Carolin Seuring, Megan L. Shelby, Robert L. Shoeman, Marcin Sikorski, Alessandro Silenzi, Claudiu A. Stan, Xintian Shi, Stephan Stern, Jola Sztuk-Dambietz, Janusz Szuba, Aleksandra Tolstikova, Martin Trebbin, Ulrich Trunk, Patrik Vagovic, Thomas Ve, Britta Weinhausen, Thomas A. White, Krzysztof Wrona, Chen Xu, Oleksandr Yefanov, Nadia Zatsepin, Jiaguo Zhang, Markus Perbandt, Adrian P. Mancuso, Christian Betzel, Henry Chapman, Anton Barty, "Megahertz serial crystallography", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-06156-7
- Mahima Sharma, Juan Mangas-Sanchez, Scott P. France, Godwin A. Aleku, Sarah L. Montgomery, Jeremy I. Ramsden, Nicholas J. Turner, Gideon Grogan, "A mechanism for reductive amination catalyzed by fungal reductive aminases (RedAms)", Acs Catalysis (2018), DOI: 10.1021/acscatal.8b03491
- Erica Elisa Ferrandi, Christopher Sayer, Simone Antonio De Rose, Elisa Guazzelli, Carlotta Marchesi, Vahid Saneei, Misha N. Isupov, Jennifer A. Littlechild, Daniela Monti, "New thermophilic α/β class epoxide hydrolases found in metagenomes from hot environments", Frontiers In Bioengineering And Biotechnology, 6 (2018), DOI: 10.3389/fbioe.2018.00144
- Gyles E. Cozier, Lauren B. Arendse, Sylva L. Schwager, Edward D. Sturrock, K. Ravi Acharya, "Molecular basis for multiple omapatrilat binding sites within the ACE C-domain: implications for drug design", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b01309
- Namrata Jain, Mohamed A. Attia, Wendy A. Offen, Gideon J. Davies, Harry Brumer, "Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo -xyloglucanases", Organic & Biomolecular Chemistry, 5 (2018), DOI: 10.1039/C8OB02250J
- James W. Noble, Rehab Almalki, S. Mark Roe, Armin Wagner, Ramona Duman, John Atack, "The X-ray structure of human calbindin-D28K: an improved model", Acta Crystallographica Section D Structural Biology, 74, 1008 - 1014 (2018), DOI: 10.1107/S2059798318011610
- Lin Huang, Saira Ashraf, David M. J. Lilley, "The role of RNA structure in translational regulation by L7Ae protein in archaea", Rna (2018), DOI: 10.1261/rna.068510.118
- Ezeogo Obaji, Teemu Haikarainen, Lari Lehtiö, "Structural basis for DNA break recognition by ARTD2/PARP2", Nucleic Acids Research, 7 (2018), DOI: 10.1093/nar/gky927
- Matthew K. Bilyard, Henry J. Bailey, Lluís Raich, Maria A. Gafitescu, Takuya Machida, Javier Iglésias-Fernández, Seung Seo Lee, Christopher D. Spicer, Carme Rovira, Wyatt W. Yue, Benjamin G. Davis, "Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis", Nature, 441 (2018), DOI: 10.1038/s41586-018-0644-7
- Yonca Yuzugullu Karakus, Gunce Goc, Sinem Balci, Briony A. Yorke, Chi H. Trinh, Michael J. Mcpherson, Arwen Pearson, Briony A. Yorke, "Identification of the site of oxidase substrate binding in Scytalidium thermophilum catalase", Acta Crystallographica Section D Structural Biology, 74, 979 - 985 (2018), DOI: 10.1107/S2059798318010628
- Louise A. Stephen, Yasmin Elmaghloob, Michael J. Mcilwraith, Tamas Yelland, Patricia Castro Sanchez, Pedro Roda-Navarro, Shehab Ismail, "The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK", Developmental Cell, 47, 122 - 132.e4 (2018), DOI: 10.1016/j.devcel.2018.08.012
- Rhys Pryce, Weng M. Ng, Antra Zeltina, Yasunori Watanabe, Kamel El Omari, Armin Wagner, Thomas A. Bowden, "Structure-based classification defines the discrete conformational classes adopted by the arenaviral GP1", Journal Of Virology (2018), DOI: 10.1128/JVI.01048-18
- Pamela A. Haile, Linda N. Casillas, Michael J. Bury, John F. Mehlmann, Robert Singhaus, Adam K. Charnley, Terry V. Hughes, Michael P. Demartino, Gren Z. Wang, Joseph J. Romano, Xiaoyang Dong, Nikolay V. Plotnikov, Ami S. Lakdawala, Maire A. Convery, Bartholomew J. Votta, David B. Lipshutz, Biva M. Desai, Barbara Swift, Carol A. Capriotti, Scott B. Berger, Mukesh K. Mahajan, Michael A. Reilly, Elizabeth J. Rivera, Helen H. Sun, Rakesh Nagilla, Carol Lepage, Michael T. Ouellette, Rachel D. Totoritis, Brian T. Donovan, Barry S. Brown, Khuram W. Chaudhary, Peter J. Gough, John Bertin, Robert W. Marquis, "Identification of quinoline-based RIP2 kinase inhibitors with an improved therapeutic index to the hERG ion channel", Acs Medicinal Chemistry Letters (2018), DOI: 10.1021/acsmedchemlett.8b00344
- Goran M. M. Rashid, Xiaoyang Zhang, Rachael C. Wilkinson, Vilmos Fulop, Betty Cottyn, Stéphanie Baumberger, Timothy D. H. Bugg, "Sphingobacterium sp. T2 manganese superoxide dismutase catalyses the oxidative demethylation of polymeric lignin via generation of hydroxyl radical", Acs Chemical Biology (2018), DOI: 10.1021/acschembio.8b00557
- Matilde De Las Rivas, Earnest James Paul Daniel, Helena Coelho, Erandi Lira-Navarrete, Lluis Raich, Ismael Compañón, Ana Diniz, Laura Lagartera, Jesús Jiménez-Barbero, Henrik Clausen, Carme Rovira, Filipa Marcelo, Francisco Corzana, Thomas A. Gerken, Ramon Hurtado-Guerrero, "Structural and mechanistic insights into the catalytic-domain-mediated short-range glycosylation preferences of galnac-t4", Acs Central Science (2018), DOI: 10.1021/acscentsci.8b00488
- Frank Lennartz, Florian Brod, Rebecca Dabbs, Kazutoyo Miura, David Mekhaiel, Arianna Marini, Matthijs Jore, Max M. Søgaard, Thomas Jørgensen, Willem A. De Jongh, Robert W. Sauerwein, Carole A. Long, Sumi Biswas, Matthew Higgins, "Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-06340-9
- Hayley J. Owen, Ruyue Sun, Asma Ahmad, Svetlana E. Sedelnikova, Patrick Baker, Mark S. Thomas, David W. Rice, "TssA from Burkholderia cenocepacia : expression, purification, crystallization and crystallographic analysis", Acta Crystallographica Section F Structural Biology Communications, 74, 536 - 542 (2018), DOI: 10.1107/S2053230X18009706
- Marcin Bielecki, Svetlana Antonyuk, Richard W. Strange, John W. Smalley, Paweł Mackiewicz, Michał Śmiga, Paulina Stępień, Mariusz Olczak, Teresa Olczak, "Tannerella forsythia Tfo belongs to Porphyromonas gingivalis HmuY-like family of proteins but differs in heme-binding properties", Bioscience Reports (2018), DOI: 10.1042/BSR20181325
- Javier Abellon-Ruiz, Michael Zahn, Arnaud Basle, Bert Van Den Berg, "Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33", Acta Crystallographica Section D Structural Biology, 74, 852 - 860 (2018), DOI: 10.1107/S205979831800904X
- Adrian Richter, Ines Rudolph, Ute Möllmann, Kerstin Voigt, Chun-Wa Chung, Onkar M. P. Singh, Michael Rees, Alfonso Mendoza-Losana, Robert Bates, Lluís Ballell, Sarah Batt, Natacha Veerapen, Klaus Fütterer, Gurdyal Besra, Peter Imming, Argyrides Argyrou, "Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1", Scientific Reports, 8 (2018), DOI: 10.1038/s41598-018-31316-6
- Nikolaj Kulahin Roed, Cristina M. Viola, Ole Kristensen, Gerd Schluckebier, Mathias Norrman, Waseem Sajid, John D. Wade, Asser Sloth Andersen, Claus Kristensen, Timothy R. Ganderton, Johan P. Turkenburg, Pierre De Meyts, Andrzej M. Brzozowski, "Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-06192-3
- [Conference Paper] Martin Maly, Tereza Skalova, Leona Svecova, Jan Dohnalek, Jan Blaha, Ondrej Vanek, Karl Harlos, Petr Kolenko, "Paired refinement: Impact of reintegration and rescaling" (2018)
- Tobias Karlberg, Peter Hornyak, Ana Filipa Pinto, Stefina Milanova, Mahsa Ebrahimi, Mikael Lindberg, Nikolai Püllen, Axel Nordström, Elinor Löverli, Rémi Caraballo, Emily V. Wong, Katja Näreoja, Ann-Gerd Thorsell, Mikael Elofsson, Enrique M. De La Cruz, Camilla Björkegren, Herwig Schüler, "14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-06194-1
- Mark Petchey, Anibal Cuetos, Benjamin Rowlinson, Stephanie Dannevald, Amina Frese, Peter W. Sutton, Sarah Lovelock, Richard C. Lloyd, Ian J. S. Fairlamb, Gideon Grogan, "The broad aryl acid specificity of the amide bond synthetase McbA suggests potential for the biocatalytic synthesis of amides", Angewandte Chemie International Edition, 57, 11584 - 11588 (2018), DOI: 10.1002/anie.201804592
- Richard Collins, Vijaykumar Karuppiah, C. Alistair Siebert, Rana Dajani, Angela Thistlethwaite, Jeremy P. Derrick, "Structural cycle of the Thermus thermophilus PilF ATPase: the powering of type IVa pilus assembly", Scientific Reports, 8 (2018), DOI: 10.1038/s41598-018-32218-3
- Giusy Tassone, Stefano Mangani, Maurizio Botta, Cecilia Pozzi, "Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart", Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics (2018), DOI: 10.1016/j.bbapap.2018.09.005
- Justin R. Harrison, Stephen Brand, Victoria Smith, David A. Robinson, Stephen Thompson, Alasdair Smith, Kenneth Davies, Ngai Mok, Leah S. Torrie, Iain Collie, Irene Hallyburton, Suzanne Norval, Frederick R. C. Simeons, Laste Stojanovski, Julie A. Frearson, Ruth Brenk, Paul G. Wyatt, Ian H. Gilbert, Kevin D. Read, "A molecular hybridization approach for the design of potent, highly selective, and brain-penetrant n-myristoyltransferase inhibitors", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b00884
- Samuel R. Dix, Ruyue Sun, Matthew J. Harris, Sarah L. Batters, Svetlana E. Sedelnikova, Patrick J. Baker, Mark S. Thomas, David W. Rice, "TssA from Aeromonas hydrophila : expression, purification and crystallographic studies", Acta Crystallographica Section F Structural Biology Communications, 74, 578 - 582 (2018), DOI: 10.1107/S2053230X18010439
- Danguole Kureisaite-Ciziene, Aravindan Varadajan, Stephen H. Mclaughlin, Marjolein Glas, Alejandro Montón Silva, Rosa Luirink, Carolin Mueller, Tanneke Den Blaauwen, Tom N. Grossmann, Joen Luirink, Jan Lowe, "Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB", Mbio, 9 (2018), DOI: 10.1128/mBio.01346-18
- Yuguang Zhao, Jingshan Ren, Weixian Lu, Karl Harlos, E. Yvonne Jones, "Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt co-receptor LRP6", Febs Letters (2018), DOI: 10.1002/1873-3468.13212
- Liang Wu, Gideon J. Davies, "Structure of the GH9 glucosidase/glucosaminidase from Vibrio cholerae", Acta Crystallographica Section F Structural Biology Communications, 74, 512 - 523 (2018), DOI: 10.1107/S2053230X18011019
- Liam Hudson, James Mui, Santiago Vázquez, Diana M. Carvalho, Eleanor Williams, Chris Jones, Alex N. Bullock, Swen Hoelder, "Novel quinazolinone inhibitors of ALK2 flip between alternate binding modes: Structure–activity relationship, structural characterization, kinase profiling, and cellular proof of concept", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b00782
- Sabrina Santarsia, Ana Sofia Grosso, Filipa Trovão, Jesús Jiménez-Barbero, Ana Luisa Carvalho, Cristina Nativi, Filipa Marcelo, "Molecular recognition of a Thomsen-Friedenreich antigen mimetic targeting human galectin-3", Chemmedchem (2018), DOI: 10.1002/cmdc.201800525
- Weiwu Ren, Robert Pengelly, Marco Farren-Dai, Saeideh Shamsi Kazem Abadi, Verena Oehler, Oluwafemi Akintola, Jason Draper, Michael Meanwell, Saswati Chakladar, Katarzyna Świderek, Vicent Moliner, Robert Britton, Tracey M. Gloster, Andrew J. Bennet, "Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-05702-7
- Daniel J. Raines, Justin E. Clarke, Elena V. Blagova, Eleanor J. Dodson, Keith S. Wilson, Anne-K. Duhme-Klair, "Redox-switchable siderophore anchor enables reversible artificial metalloenzyme assembly", Nature Catalysis, 308 (2018), DOI: 10.1038/s41929-018-0124-3
- Zhen Wang, Yali Zhang, Daniel M. Pinkas, Alice Fox, Jinfeng Luo, Huocong Huang, Shengyang Cui, Qiuping Xiang, Tingting Xu, Qiuju Xun, Dongsheng Zhu, Zheng-Chao Tu, Xiaomei Ren, Rolf A. Brekken, Alex N. Bullock, Guang Liang, Ke Ding, Xiaoyun Lu, "Design, synthesis and biological evaluation of 3-(Imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as dual inhibitors of discoidin domain receptor 1 and 2 (DDR1/2)", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b01045
- Sean David Reiff, Rose Mantel, Lisa L. Smith, Joseph T. Greene, Elizabeth M. Muhowski, Catherine A. Fabian, Virginia M. Goettl, Minh Tran, Bonnie Harrington, Kerry A. Rogers, Farrukh T. Awan, Kami Maddocks, Leslie Andritsos, Amy M. Lehman, Deepa Sampath, Rosa Lapalombella, Sudharshan Eathiraj, Giovanni Abbadessa, Brian Schwartz, Amy Johnson, John C. Byrd, Jennifer A. Woyach, "The BTK inhibitor ARQ 531 targets ibrutinib resistant CLL and Richter's transformation", Cancer Discovery (2018), DOI: 10.1158/2159-8290.CD-17-1409
- Camilo E. Quevedo, Abimael Cruz-Migoni, Nicolas Bery, Ami Miller, Tomoyuki Tanaka, Donna Petch, Carole J. R. Bataille, Lydia Y. W. Lee, Phillip S. Fallon, Hanna Tulmin, Matthias T. Ehebauer, Narcis Fernandez-Fuentes, Angela J. Russell, Stephen Carr, Simon E. V. Phillips, Terence Rabbitts, "Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-05707-2
- Manickam Yogavel, Joanne E. Nettleship, Akansha Sharma, Karl Harlos, Abhishek Jamwal, Rini Chaturvedi, Manmohan Sharma, Vitul Jain, Jyoti Chhibber-Goel, Amit Sharma, "Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase–dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance", Journal Of Biological Chemistry (2018), DOI: 10.1074/jbc.RA118.004558
- Changrong Ge, Bingze Xu, Bibo Liang, Erik Lönnblom, Susanna L. Lundström, Roman A. Zubarev, Burcu Ayoglu, Peter Nilsson, Thomas Skogh, Alf Kastbom, Vivianne Malmström, Lars Klareskog, René E. M. Toes, Theo Rispens, Doreen Dobritzsch, Rikard Holmdahl, "Structural basis of cross-reactivity of anti-citrullinated protein antibodies", Arthritis & Rheumatology (2018), DOI: 10.1002/art.40698
- Mohanram Sivaraja, Nicola Pozzi, Matthew Rienzo, Kenneth Lin, Timothy P. Shiau, Daniel M. Clemens, Lev Igoudin, Piotr Zalicki, Stephanie S. Chang, M. Angels Estiarte, Kevin M. Short, David C. Williams, Anirban Datta, Enrico Di Cera, David B. Kita, "Reversible covalent direct thrombin inhibitors", Plos One, 13 (2018), DOI: 10.1371/journal.pone.0201377
- Rhiannon M. Evans, Philip A. Ash, Stephen E. Beaton, Emily J. Brooke, Kylie A. Vincent, Stephen B. Carr, Fraser A. Armstrong, "Mechanistic exploitation of a self-repairing, blocked proton transfer pathway in an O2-tolerant [NiFe]-hydrogenase", Journal Of The American Chemical Society (2018), DOI: 10.1021/jacs.8b04798
- Jiwei Liu, Jeffrey K. Noel, Harry H. Low, "Structural basis for membrane tethering by a bacterial dynamin-like pair", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-05523-8
- Haigang Song, Niels S. Van Der Velden, Sally L. Shiran, Patrick Bleiziffer, Christina Zach, Ramon Sieber, Aman S. Imani, Florian Krausbeck, Markus Aebi, Michael F. Freeman, Sereina Riniker, Markus Künzler, James H. Naismith, "A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds", Science Advances, 4 (2018), DOI: 10.1126/sciadv.aat2720
- Nikolaos D. Georgakopoulos, Sandeep K. Talapatra, Jemma Gatliff, Frank Kozielski, Geoff Wells, "Modified peptide inhibitors of the keap1-Nrf2 protein-protein interaction incorporating unnatural amino acids", Chembiochem, 85 (2018), DOI: 10.1002/cbic.201800170
- Nabanita Bhattacharyya, Irene Nailain Nkumama, Zaccheus Newland-Smith, Li-Ying Lin, Wen Yin, Rebecca E. Cullen, Jack S. Griffiths, Alexander R. Jarvis, Michael J. Price, Pei Ying Chong, Russell Wallis, Helen O'Hare, "An aspartate-specific solute-binding protein regulates protein kinase G activity to control glutamate metabolism in mycobacteria", Mbio, 9 (2018), DOI: 10.1128/mBio.00931-18
- Kelly Stefany Tuna Frade, Andreia Cecília Pimenta Fernandes, Celia Marisa Silveira, Carlos Frazao, Elin Moe, "A novel bacterial class V dye-decolourizing peroxidase from the extremophile Deinococcus radiodurans : cloning, expression optimization, purification, crystallization, initial characterization and X-ray diffraction analysis", Acta Crystallographica Section F Structural Biology Communications, 74, 419 - 424 (2018), DOI: 10.1107/S2053230X18008488
- Dirk Maurer, Bernhard Lohkamp, Michael Krumpel, Mikael Widersten, Doreen Dobritzsch, "Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism", Biochemical Journal (2018), DOI: 10.1042/BCJ20180222
- Xavier Lucas, Inge Van Molle, Alessio Ciulli, "Surface probing by fragment-based screening and computational methods identifies ligandable pockets on the von Hippel-Lindau (VHL) E3 ubiquitin ligase", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b00842
- Luke A. Johnson, Angus J. Robertson, Nicola J. Baxter, Clare R. Trevitt, Claudine Bisson, Yi Jin, Henry P. Wood, Andrea M. Hounslow, Matthew J. Cliff, G. Michael Blackburn, Matthew W. Bowler, Jonathan P. Waltho, "van der Waals contact between nucleophile and transferring phosphorus is insufficient to achieve enzyme transition state architecture", Acs Catalysis (2018), DOI: 10.1021/acscatal.8b01612
- Juan Carlos De La Concepcion, Marina Franceschetti, Abbas Maqbool, Hiromasa Saitoh, Ryohei Terauchi, Sophien Kamoun, Mark J. Banfield, "Polymorphic residues in rice NLRs expand binding and response to effectors of the blast pathogen", Nature Plants, 354 (2018), DOI: 10.1038/s41477-018-0194-x
- Elise Kaplan, Nicholas P. Greene, Allister Crow, Vassilis Koronakis, "Insights into bacterial lipoprotein trafficking from a structure of LolA bound to the LolC periplasmic domain", Proceedings Of The National Academy Of Sciences, 8 (2018), DOI: 10.1073/pnas.1806822115
- Jianshu Dong, Daisuke Sasaki, Robert R. Eady, Svetlana V. Antonyuk, S. Samar Hasnain, "Identification of a tyrosine switch in copper-haem nitrite reductases", Iucrj, 5, 510 - 518 (2018), DOI: 10.1107/S2052252518008242
- Ivan Laponogov, Xiao-Su Pan, Dennis A. Veselkov, Galyna B. Skamrova, Trishant R. Umrekar, L. Mark Fisher, Mark Sanderson, "Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-05005-x
- [Thesis] Jamie Littlejohn, "Structural characterisation of oligosaccharide recognition by surfactant protein D" (2018)
- Ona K. Miller, Mark J. Banfield, Ulrich Schwarz-Linek, "A new structural class of bacterial thioester domains reveals a slipknot topology", Protein Science (2018), DOI: 10.1002/pro.3478
- Christopher A. Rice, Sara J. Campbell, Claudine Bisson, Hayley J. Owen, Svetlana E. Sedelnikova, Patrick J. Baker, David W. Rice, Fiona L. Henriquez, Craig W. Roberts, "Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials", Plos One, 13 (2018), DOI: 10.1371/journal.pone.0198827
- Kane Mcquaid, James Pearce Hall, John Alan Brazier, David John Cardin, Christine Janet Cardin, "X-ray crystal structures show DNA stacking advantage of terminal nitrile substitution in Ru-dppz complexes", Chemistry - A European Journal (2018), DOI: 10.1002/chem.201803021
- Jianfeng Yu, Jana Knoppová, Franck Michoux, Wojciech Bialek, Ernesto Cota, Mahendra K. Shukla, Adéla Strašková, Guillem Pascual Aznar, Roman Sobotka, Josef Komenda, James W. Murray, Peter J. Nixon, "Ycf48 involved in the biogenesis of the oxygen-evolving photosystem II complex is a seven-bladed beta-propeller protein", Proceedings Of The National Academy Of Sciences, 49 (2018), DOI: 10.1073/pnas.1800609115
- David I. Stuart, Jingshan Ren, Xiangxi Wang, Zihe Rao, Elizabeth E. Fry, "Hepatitis A virus capsid structure", Cold Spring Harbor Perspectives In Medicine (2018), DOI: 10.1101/cshperspect.a031807
- George A. Ward, Edward J. Lewis, Jong Sook Ahn, Christopher N. Johnson, John F. Lyons, Vanessa Martins, Joanne M. Munck, Sharna J. Rich, Tomoko Smyth, Neil T. Thompson, Pamela A. Williams, Nicola E. Wilsher, Nicola G. Wallis, Gianni Chessari, "ASTX660, a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP, potently induces TNFα-dependent apoptosis in cancer cell lines and inhibits tumor growth", Molecular Cancer Therapeutics, 17, 1381 - 1391 (2018), DOI: 10.1158/1535-7163.MCT-17-0848
- Jamie R. Littlejohn, Ruben F. Da Silva, William A. Neale, Carrie C. Smallcombe, Howard W. Clark, Rose-Marie A. Mackay, Alastair S. Watson, Jens Madsen, Derek W. Hood, Ian Burns, Trevor J. Greenhough, Annette K. Shrive, "Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides reveals alternative binding modes for the same LPS", Plos One, 13 (2018), DOI: 10.1371/journal.pone.0199175
- Robert Andrew Field, Sakonwan Kuhaudomlarp, Samuel Walpole, Clare Stevenson, Sergey Nepogodiev, David Lawson, Jesus Angulo, "Unravelling the relaxed specificity of laminaribiose phosphorylase from Paenibacillus sp. strain YM-1 towards mannose 1-phosphate", Chembiochem (2018), DOI: 10.1002/cbic.201800260
- Andrea Testa, Xavier Lucas, Guilherme V. Castro, Kwok-Ho Chan, Jane E. Wright, Andrew C. Runcie, Morgan S. Gadd, William T. A. Harrison, Eun-Jung Ko, Daniel Fletcher, Alessio Ciulli, "3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation", Journal Of The American Chemical Society (2018), DOI: 10.1021/jacs.8b05807
- Stephen Moss, Vasanta Subramanian, K. Ravi Acharya, "High resolution crystal structure of substrate-free human neprilysin", Journal Of Structural Biology (2018), DOI: 10.1016/j.jsb.2018.06.004
- Lin Huang, David M. J. Lilley, "Structure and ligand binding of the SAM-V riboswitch", Nucleic Acids Research, 78 (2018), DOI: 10.1093/nar/gky520
- Sarah L. Rouse, Fisentzos Stylianou, H. Y. Grace Wu, Jamie-Lee Berry, Lee Sewell, R. Marc L. Morgan, Andrea C. Sauerwein, Steve Matthews, "The FapF amyloid secretion transporter possesses an atypical asymmetric coiled coil", Journal Of Molecular Biology (2018), DOI: 10.1016/j.jmb.2018.06.007
- Sam J. B. Mallinson, Melodie M. Machovina, Rodrigo L. Silveira, Marc Garcia-Borràs, Nathan Gallup, Christopher W. Johnson, Mark D. Allen, Munir S. Skaf, Michael F. Crowley, Ellen L. Neidle, Kendall N. Houk, Gregg T. Beckham, Jennifer L. Dubois, John E. Mcgeehan, "A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-04878-2
- Ana Laura Stern, Sander Egbert Van Der Verren, Sandesh Kanchugal Puttaswamy, Joakim Näsvall, Hugo Gutierrez De Teran, Maria Selmer, "Structural mechanism of AadA, a dual specificity aminoglycoside adenyl transferase from Salmonella enterica", Journal Of Biological Chemistry (2018), DOI: 10.1074/jbc.RA118.003989
- Linas Urnavicius, Clinton K. Lau, Mohamed M. Elshenawy, Edgar Morales-Rios, Carina Motz, Ahmet Yildiz, Andrew Carter, "Cryo-EM shows how dynactin recruits two dyneins for faster movement", Nature, 554, 202 - 206 (2018), DOI: 10.1038/nature25462
- Matthias G. J. Baud, Matthias R. Bauer, Lorena Verduci, Felix A. Dingler, Ketan J. Patel, Deeptee Horil Roy, Andreas C. Joerger, Alan R. Fersht, "Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines", European Journal Of Medicinal Chemistry, 152, 101 - 114 (2018), DOI: 10.1016/j.ejmech.2018.04.035
- Richard C. White, Felizza F. Gunderson, Jessica Y. Tyson, Katherine H. Richardson, Theo J. Portlock, James A. Garnett, Nicholas P. Cianciotto, "Type II secretion-dependent aminopeptidase LapA and acyltransferase PlaC are redundant for nutrient acquisition during Legionella pneumophila intracellular infection of amoebas", Mbio, 9 (2018), DOI: 10.1128/mBio.00528-18
- Andrew J. Thompson, Richard J. Spears, Yanping Zhu, Michael D. L. Suits, Spencer J. Williams, Harry J. Gilbert, Gideon J. Davies, "Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif", Acta Crystallographica Section D Structural Biology, 74, 394 - 404 (2018), DOI: 10.1107/S2059798318002942
- Anne Walter, Apirat Chaikuad, Renate Helmer, Nadège Loaëc, Lutz Preu, Ingo Ott, Stefan Knapp, Laurent Meijer, Conrad Kunick, "Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype", Plos One, 13 (2018), DOI: 10.1371/journal.pone.0196761
- Pronay Das, Palak Babbar, Nipun Malhotra, Manmohan Sharma, Gorakhnath R. Jachak, Rajesh G. Gonnade, Dhanasekaran Shanmugam, Karl Harlos, Manickam Yogavel, Amit Sharma, D. Srinivasa Reddy, "Specific stereoisomeric conformations determine the drug potency of cladosporin scaffold against malarial parasite", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b00565
- Katie Tungatt, Garry Dolton, Sophie B. Morgan, Meriem Attaf, Anna Fuller, Thomas Whalley, Johanneke D. Hemmink, Emily Porter, Barbara Szomolay, Maria Montoya, John A. Hammond, John J. Miles, David K. Cole, Alain Townsend, Mick Bailey, Pierre Rizkallah, Bryan Charleston, Elma Tchilian, Andrew K. Sewell, "Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig", Plos Pathogens, 14 (2018), DOI: 10.1371/journal.ppat.1007017
- Christopher Asquith, Paulo Godoi, Rafael M. Counago, Tuomo Laitinen, John W. Scott, Christopher Langendorf, Jonathan S. Oakhill, David Drewry, William Zuercher, Panayiotis Koutentis, Timothy Willson, Andreas Kalogirou, "1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors", Molecules, 23 (2018), DOI: 10.3390/molecules23051221
- Marie Prevost, Gabriel Waksman, "X-ray crystal structures of the type IVb secretion system DotB ATPases", Protein Science (2018), DOI: 10.1002/pro.3439
- Nimesh Joseph, Caezar Al-Jassar, Christopher M. Johnson, Antonina Andreeva, Deepak D. Barnabas, Stefan M. V. Freund, Fanni Gergely, Mark Van Breugel, "Disease-associated mutations in CEP120 destabilize the protein and impair ciliogenesis", Cell Reports, 23, 2805 - 2818 (2018), DOI: 10.1016/j.celrep.2018.04.100
- Michael Forster, Apirat Chaikuad, Teodor Dimitrov, Eva Döring, Julia Holstein, Benedict-Tilman Berger, Matthias Gehringer, Kamran Ghoreschi, Susanne Müller, Stefan Knapp, Stefan A. Laufer, "Development, optimization and structure–activity relationships of covalent-reversible JAK3 inhibitors based on a tricyclic imidazo[5,4-d]pyrrolo[2,3-b]pyridine scaffold", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b00571
- Olga V. Moroz, Pernille Foged Jensen, Sean P Mcdonald, Nicholas Mcgregor, Elena Blagova, Gerard Comamala, Dorotea R. Segura, Lars Anderson, Santhosh M Vasu, Vasudeva P Rao, Lars Giger, Trine Holst Sørensen, Rune Nygaard Monrad, Allan Svendsen, Jens Erik Nielsen, Bernard Henrissat, Gideon Davies, Harry Brumer, Kasper D. Rand, Keith S. Wilson, "Structural dynamics and catalytic properties of a multi-modular xanthanase", Acs Catalysis (2018), DOI: 10.1021/acscatal.8b00666
- Meng Yuan, Iain W. Mcnae, Yiyuan Chen, Elizabeth A. Blackburn, Martin A. Wear, Paul A. M. Michels, Linda A. Fothergill-Gilmore, Ted Hupp, Malcolm D. Walkinshaw, "An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor", Biochemical Journal (2018), DOI: 10.1042/BCJ20180171
- [Science Highlight] Diamond Light Source, "The proteins that bind" (2018)
- Antoni R. Blaazer, Abhimanyu K. Singh, Erik De Heuvel, Ewald Edink, Kristina M. Orrling, Johan J. N. Veerman, Toine Van Den Bergh, Chimed Jansen, Erin Balasubramaniam, Wouter J. Mooij, Hans Custers, Maarten Sijm, Daniel N. A. Tagoe, Titilola D. Kalejaiye, Jane C. Munday, Hermann Tenor, An Matheeussen, Maikel Wijtmans, Marco Siderius, Chris De Graaf, Louis Maes, Harry P. De Koning, David S. Bailey, Geert Jan Sterk, Iwan J. P. De Esch, David G. Brown, Rob Leurs, "Targeting a subpocket in Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) enables the structure-based discovery of selective inhibitors with trypanocidal activity", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.7b01670
- [Thesis] Katie Melissa Duffell, "Design and characterisation of tool inhibitors of DNA damage response proteins" (2018)
- Jingxu Guo, Alun Coker, Steve P. Wood, Jonathan Cooper, Ronan M. Keegan, Nasir Ahmad, Majida Atta Muhammad, Naeem Rashid, Muhummad Akhtar, "Structure and function of the type III pullulan hydrolase from Thermococcus kodakarensis", Acta Crystallographica Section D Structural Biology, 74, 305 - 314 (2018), DOI: 10.1107/S2059798318001754
- Austin Whitewood, Abhimanyu K. Singh, David G. Brown, Benjamin T. Goult, "Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex", Febs Letters (2018), DOI: 10.1002/1873-3468.13074
- David C. Briggs, Erhard Hohenester, "Structural basis for the initiation of glycosaminoglycan biosynthesis by human xylosyltransferase 1", Structure (2018), DOI: 10.1016/j.str.2018.03.014
- James A. W. Stowell, Jane L. Wagstaff, Chris H. Hill, Minmin Yu, Stephen H. Mclaughlin, Stefan M. V. Freund, Lori A. Passmore, "A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding", Journal Of Biological Chemistry (2018), DOI: 10.1074/jbc.RA118.002291
- Monisha Pathania, Silvia Acosta-Gutierrez, Satya Pratyusha Bhamidimarri, Arnaud Basle, Mathias Winterhalter, Matteo Ceccarelli, Bert Van Den Berg, "Unusual constriction zones in the major porins OmpU and OmpT from Vibrio cholerae", Structure (2018), DOI: 10.1016/j.str.2018.03.010
- [Thesis] Andrei Kamenski, "Biochemical and structural characterisation of human phosphatidylinositol transfer protein Nir2 and American hookworm lipid binding protein Na-FAR-1" (2018)
- Harry P. Austin, Mark D. Allen, Bryon S. Donohoe, Nicholas A. Rorrer, Fiona L. Kearns, Rodrigo L. Silveira, Benjamin C. Pollard, Graham Dominick, Ramona Duman, Kamel El Omari, Vitaliy Mykhaylyk, Armin Wagner, William E. Michener, Antonella Amore, Munir S. Skaf, Michael F. Crowley, Alan W. Thorne, Christopher W. Johnson, H. Lee Woodcock, John E. Mcgeehan, Gregg T. Beckham, "Characterization and engineering of a plastic-degrading aromatic polyesterase", Proceedings Of The National Academy Of Sciences, 39 (2018), DOI: 10.1073/pnas.1718804115
- Christopher J. Holland, Bruce J. Maclachlan, Valentina Bianchi, Sophie J. Hesketh, Richard Morgan, Owen Vickery, Anna M. Bulek, Anna Fuller, Andrew Godkin, Andrew K. Sewell, Pierre Rizkallah, Stephen Wells, David Cole, "In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility", Frontiers In Immunology, 9 (2018), DOI: 10.3389/fimmu.2018.00674
- Peter D. Craggs, Stephane Mouilleron, Martin Rejzek, Cesira De Chiara, Robert J. Young, Robert A. Field, Argyrides Argyrou, Luiz Pedro S. De Carvalho, "The mechanism of acetyl transfer catalyzed by Mycobacterium tuberculosis GlmU", Biochemistry (2018), DOI: 10.1021/acs.biochem.8b00121
- Kangsa Amporndanai, Rachel M. Johnson, Paul M. O'Neill, Colin W. G. Fishwick, Alexander H. Jamson, Shaun Rawson, Stephen Muench, S. Samar Hasnain, Svetlana V. Antonyuk, "X-ray and cryo-EM structures of inhibitor-bound cytochrome bc 1 complexes for structure-based drug discovery", Iucrj, 5 (2018), DOI: 10.1107/S2052252518001616
- Saannya Sequeira, Devon Kavanaugh, Donald A. Mackenzie, Tanja Šuligoj, Samuel Walpole, Charlotte Leclaire, A. Patrick Gunning, Dimitrios Latousakis, William G. T. Willats, Jesus Angulo, Changjiang Dong, Nathalie Juge, "Structural basis for the role of serine-rich repeat proteins from Lactobacillus reuteri in gut microbe–host interactions", Proceedings Of The National Academy Of Sciences, 404 (2018), DOI: 10.1073/pnas.1715016115
- Selena G. Burgess, Manjeet Mukherjee, Sarah Sabir, Nimesh Joseph, Cristina Gutiérrez‐caballero, Mark W. Richards, Nicolas Huguenin‐dezot, Jason W. Chin, Eileen J. Kennedy, Mark Pfuhl, Stephen J. Royle, Fanni Gergely, Richard Bayliss, "Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix", The Embo Journal (2018), DOI: 10.15252/embj.201797902
- Rommel Santiago Granja-Travez, Rachael Wilkinson, Gabriela Felix Persinoti, Fabio M. Squina, Vilmos Fulop, Timothy D. H. Bugg, "Structural and functional characterisation of multi-copper oxidase CueO from lignin-degrading bacterium Ochrobactrum sp. reveal its activity towards lignin model compounds and lignosulfonate", The Febs Journal, 27 (2018), DOI: 10.1111/febs.14437
- Anastasia Amato, Xavier Lucas, Alessio Bortoluzzi, David Wright, Alessio Ciulli, "Targeting ligandable pockets on PHD zinc finger domains by a fragment-based approach", Acs Chemical Biology (2018), DOI: 10.1021/acschembio.7b01093
- Stephen E. Beaton, Rhiannon M. Evans, Alexander J. Finney, Ciaran M Lamont, Fraser A. Armstrong, Frank Sargent, Stephen B. Carr, "The structure of hydrogenase-2 from Escherichia coli: implications for H2-driven proton pumping", Biochemical Journal (2018), DOI: 10.1042/BCJ20180053
- Thomas Germe, Judit Voros, Frederic Jeannot, Thomas Taillier, Robert A. Stavenger, Eric Bacqué, Anthony Maxwell, Benjamin D. Bax, "A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance", Nucleic Acids Research, 16 (2018), DOI: 10.1093/nar/gky181
- Hanan L. Messiha, Syed T. Ahmed, Vijaykumar Karuppiah, Reynier Suardiaz, Gabriel A. Ascue Avalos, Natalie Fey, Stephen Yeates, Helen S. Toogood, Adrian J. Mulholland, Nigel S. Scrutton, "Biocatalytic routes to lactone monomers for polymer production", Biochemistry (2018), DOI: 10.1021/acs.biochem.8b00169
- Verity A. Jackson, Dimphna H. Meijer, Maria Carrasquero, Laura S. Van Bezouwen, Edward D. Lowe, Colin Kleanthous, Bert J. C. Janssen, Elena Seiradake, "Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-03460-0
- Sybrin P. Schröder, Liang Wu, Marta Artola, Thomas Hansen, Wendy A. Offen, Maria J. Ferraz, Kah-Yee Li, Johannes M. F. G. Aerts, Gijsbert A. Van Der Marel, Jeroen D. C. Codée, Gideon J. Davies, Herman S. Overkleeft, "Gluco-1H-imidazole: a new class of azole-type β-glucosidase inhibitor", Journal Of The American Chemical Society (2018), DOI: 10.1021/jacs.8b02399
- [Book Chapter] Christine J. Cardin, James Hall, "Structural studies of DNA-binding metal complexes of therapeutic importance" (2018)
- Sarah E. Wilkins, Saiful Islam, Joan M. Gannon, Suzana Markolovic, Richard J. Hopkinson, Wei Ge, Christopher J. Schofield, Rasheduzzaman Chowdhury, "JMJD5 is a human arginyl C-3 hydroxylase", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-03410-w
- Jonathan R. Davies, Gavin S. Hackett, Sai Man Liu, Ravi Acharya, "High resolution crystal structures of the receptor-binding domain of Clostridium botulinum neurotoxin serotypes A and FA", Peerj, 6 (2018), DOI: 10.7717/peerj.4552
- Fruzsina Hobor, Andre Dallmann, Neil J. Ball, Carla Cicchini, Cecilia Battistelli, Roksana W. Ogrodowicz, Evangelos Christodoulou, Stephen R. Martin, Alfredo Castello, Marco Tripodi, Ian A. Taylor, Andres Ramos, "A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets", Nature Communications, 9 (2018), DOI: 10.1038/s41467-018-03182-3
- Gregory B. Craven, Dominic P. Affron, Charlotte E. Allen, Stefan Matthies, Joe G. Greener, Rhodri M. L. Morgan, Edward W. Tate, Alan Armstrong, David J. Mann, "High-throughput kinetic analysis for target-directed covalent ligand discovery", Angewandte Chemie International Edition (2018), DOI: 10.1002/anie.201711825
- Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, Charlotte Taylor, Juliet Goldsmith, Ming Wang, Kenta Masuda, Eli M. Carrami, David Mannion, Fabrizio Miranda, Sandra Herrero-Gonzalez, Karin Hellner, Fiona Chen, Abdulkhaliq Alsaadi, Ashwag Albukhari, Donatien Chedom Fotso, Christopher Yau, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Stefan Knapp, Nathanael S. Gray, Leticia Campo, Kevin A. Myers, Sunanda Dhar, David Ferguson, Robert C. Bast, Anil K. Sood, Frank Von Delft, Ahmed Ashour Ahmed, "Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation", Nature Communications, 9 (2018), DOI: 10.1038/s41467-017-02811-7
- Federica Prati, Fabio Zuccotto, Daniel Fletcher, Maire A. Convery, Raquel Fernandez-Menendez, Robert Bates, Lourdes Encinas, Jingkun Zeng, Chun-Wa Chung, Paco De Dios Anton, Alfonso Mendoza-Losana, Claire Mackenzie, Simon R. Green, Margaret Huggett, David Barros, Paul G. Wyatt, Peter C. Ray, "Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA", Chemmedchem (2018), DOI: 10.1002/cmdc.201700774
- Mohamed A. Attia, Cassandra E. Nelson, Wendy A. Offen, Namrata Jain, Gideon J. Davies, Jeffrey G. Gardner, Harry Brumer, "In vitro and in vivo characterization of three Cellvibrio japonicus glycoside hydrolase family 5 members reveals potent xyloglucan backbone-cleaving functions", Biotechnology For Biofuels, 11 (2018), DOI: 10.1186/s13068-018-1039-6
- Gyles E. Cozier, Sylva L. Schwager, Rajni K. Sharma, Kelly Chibale, Edward D. Sturrock, K. Ravi Acharya, "Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE: a molecular basis for domain-selectivity", The Febs Journal (2018), DOI: 10.1111/febs.14421
- Jessica Iegre, Paul Brear, Claudia De Fusco, Masao Yoshida, Sophie L. Mitchell, Maxim Rossmann, Laura Carro, Hannah F. Sore, Marko Hyvonen, David R. Spring, "Second-generation CK2α inhibitors targeting the αD pocket", Chemical Science, 9, 3041 - 3049 (2018), DOI: 10.1039/C7SC05122K
- Andrew Currin, Mark S. Dunstan, Linus O. Johannissen, Katherine A. Hollywood, Maria Vinaixa, Adrian J. Jervis, Neil Swainston, Nicholas J. W. Rattray, John M. Gardiner, Douglas B. Kell, Eriko Takano, Helen S. Toogood, Nigel S. Scrutton, "Engineering the “missing link” in biosynthetic (−)-menthol production: bacterial isopulegone isomerase", Acs Catalysis (2018), DOI: 10.1021/acscatal.7b04115
- Peter C. E. Moody, Emma L. Raven, "The nature and reactivity of ferryl heme in compounds I and II", Accounts Of Chemical Research (2018), DOI: 10.1021/acs.accounts.7b00463
- Yves Nkizinkiko, Jenny Desantis, Jarkko Koivunen, Teemu Haikarainen, Sudarshan Murthy, Luca Sancineto, Serena Massari, Federica Ianni, Ezeogo Obaji, Maria I. Loza, Taina Pihlajaniemi, Jose Brea, Oriana Tabarrini, Lari Lehtiö, "2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors", Scientific Reports, 8 (2018), DOI: 10.1038/s41598-018-19872-3
- Jamal O. M. Almitairi, Umakhanth Venkatraman Girija, Christopher Furze, Xanthe Simpson-Gray, Farah Badakshi, Jamie E. Marshall, Wilhelm J. Schwaeble, Daniel A. Mitchell, Peter C. E. Moody, Russell Wallis, "Structure of the C1r–C1s interaction of the C1 complex of complement activation", Proceedings Of The National Academy Of Sciences, 265 (2018), DOI: 10.1073/pnas.1718709115
- Frederic Jabs, Melanie Plum, Nick S. Laursen, Rasmus K. Jensen, Brian Mølgaard, Michaela Miehe, Marco Mandolesi, Michèle M. Rauber, Wolfgang Pfützner, Thilo Jakob, Christian Möbs, Gregers R. Andersen, Edzard Spillner, "Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction", Nature Communications, 9 (2018), DOI: 10.1038/s41467-017-02312-7
- Thomas R. Cotton, Gerhard Fischer, Xuelu Wang, Jason C. Mccoy, Magdalena Czepnik, Thomas B Thompson, Marko Hyvonen, "Structure of the human myostatin precursor and determinants of growth factor latency", The Embo Journal (2018), DOI: 10.15252/embj.201797883
- Sebastian Zoll, Harriet Lane-Serff, Shahid Mehmood, Jonathan Schneider, Carol V. Robinson, Mark Carrington, Matthew K. Higgins, "The structure of serum resistance-associated protein and its implications for human African trypanosomiasis", Nature Microbiology, 75 (2018), DOI: 10.1038/s41564-017-0085-3
- Peter Canning, Kwangjin Park, João Gonçalves, Chunmei Li, Conor J. Howard, Timothy D. Sharpe, Liam J. Holt, Laurence Pelletier, Alex N. Bullock, Michel R. Leroux, "CDKL family kinases have evolved distinct structural features and ciliary function", Cell Reports, 22, 885 - 894 (2018), DOI: 10.1016/j.celrep.2017.12.083
- Steinar Halldorsson, Sai Li, Mengqiu Li, Karl Harlos, Thomas A. Bowden, Juha T. Huiskonen, "Shielding and activation of a viral membrane fusion protein", Nature Communications, 9 (2018), DOI: 10.1038/s41467-017-02789-2
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
Diamond Light Source Ltd
Diamond House
Harwell Science & Innovation Campus
Didcot
Oxfordshire
OX11 0DE
Copyright © Diamond Light Source. Diamond Light Source® and the Diamond logo are registered trademarks of Diamond Light Source Ltd
Registered in England and Wales at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom. Company number: 4375679. VAT number: 287 461 957. Economic Operators Registration and Identification (EORI) number: GB287461957003.