Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I03 Contact
Beamline Phone Number:
+44 (0) 1235 778707
Acting Principal Beamline Scientist:
Dave Hall
Tel: +44 (0) 1235 778926
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I03 MX
Status: Operational
Beamsize: 90 µm x 20 µm
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
These publications are based on data gathered on beamline I03. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
33 items found for 2009 [total: 2353]
Investigations into protein crystallization in the presence of a strong magnetic field Crystal Growth & Design, 10 (2) Dec 2009 DOI: 10.1021/cg901109e
Journal Paper I03-Macromolecular Crystallography
A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation Journal Of Molecular Biology, Nov 2009 DOI: 10.1016/j.jmb.2009.11.029
Journal Paper I03-Macromolecular Crystallography
A cancer-associated Aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2 Journal Of Biological Chemistry, Oct 2009 DOI: 10.1074/jbc.M109.032722
Characterization of a C-C hydrolase from Mycobacterium tuberuclosis involved in cholesterol metabolism Journal Of Biological Chemistry, Oct 2009 DOI: 10.1074/jbc.M109.058081
The structure of Mycobacterium tuberculosis CYP125: Molecular basis for cholesterol binding in a P450 needed for host infection Journal Of Biological Chemistry, Oct 2009 DOI: 10.1074/jbc.M109.032706
A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry Chembiochem, 10 (17) Oct 2009 DOI: 10.1002/cbic.200900537
Journal Paper I03-Macromolecular Crystallography
Structure and RNA binding of the mouse Pumilio-2 Puf domain Journal Of Structural Biology, 167 (3) Sept 2009 DOI: 10.1016/j.jsb.2009.06.007
Journal Paper I03-Macromolecular Crystallography
The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation Bmc Structural Biology, 9 (55) Aug 2009 DOI: 10.1186/1472-6807-9-55
Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core Protein Engineering, Design And Selection, 22 (7) Jul 2009 DOI: 10.1093/protein/gzp018
Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release Biochemistry, 48 (23) June 2009 DOI: 10.1021/bi802335s
Characterisation of Bombyx mori Odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components Journal Of Molecular Biology, 389 (3) June 2009 DOI: 10.1016/j.jmb.2009.04.015
Journal Paper I03-Macromolecular Crystallography
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP Nature Structural & Molecular Biology, 16 (7) June 2009 DOI: 10.1038/nsmb.1607
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2 Structure , 17 (6) June 2009 DOI: 10.1016/j.str.2009.03.017
Journal Paper I03-Macromolecular Crystallography
Crystal structures of Cif from bacterial pathogens Photorhabdus luminescens and Burkholderia pseudomallei Plos One, May 2009 DOI: 10.1371/journal.pone.0005582
Structure of the human Nac1 POZ domain Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65 May 2009 DOI: 10.1107/S1744309109012214
Journal Paper I03-Macromolecular Crystallography
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases Journal Of Medicinal Chemistry, 52 (9) May 2009 DOI: 10.1021/jm800963t
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65 May 2009 DOI: 10.1107/S1744309109012007
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases Nature Structural & Molecular Biology, 16 (6) May 2009 DOI: 10.1038/nsmb.1604
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis The Embo Journal, 28 (7) Apr 2009 DOI: 10.1038/emboj.2009.25
Journal Paper I03-Macromolecular Crystallography
Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of α1-antitrypsin: implications for disease and drug design Journal Of Molecular Biology, 387 (4) Apr 2009 DOI: 10.1016/j.jmb.2009.01.069
Metal-binding loop length and not sequence dictates structure Proceedings Of The National Academy Of Sciences, 106 (14) Mar 2009 DOI: 10.1073/pnas.0811324106
Journal Paper I03-Macromolecular Crystallography
Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity Journal Of Molecular Biology, 387(1) Mar 2009 DOI: 10.1016/j.jmb.2008.12.086
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structures of Leishmania major orthologues of macrophage migration inhibitory factor Biochemical And Biophysical Research Communications, 380 (3) Mar 2009 DOI: 10.1016/j.bbrc.2009.01.030
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystal structure of Streptococcus pyogenes Sortase A: Implications for sortase mechanism Journal Of Biological Chemistry, 284 (11) Mar 2009 DOI: 10.1074/jbc.M805406200
Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function Proceedings Of The National Academy Of Sciences, 106 (9) Mar 2009 DOI: 10.1073/pnas.0808972106
Journal Paper I03-Macromolecular Crystallography
Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates Nature, 458 Feb 2009 DOI: 10.1038/nature07769
Journal Paper I03-Macromolecular Crystallography
Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A Biochemical And Biophysical Research Communications, 381 (1) Feb 2009 DOI: 10.1016/j.bbrc.2009.02.003
Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS Proceedings Of The National Academy Of Sciences, 106 (5) Feb 2009 DOI: 10.1073/pnas.0809020106
Insights into the conformational variability and regulation of human Nek2 kinase Journal Of Molecular Biology, 386 (2) Feb 2009 DOI: 10.1016/j.jmb.2008.12.033
Structural basis of the radicicol resistance displayed by a fungal Hsp90 Acs Chemical Biology, 4 (4) Feb 2009 DOI: 10.1021/cb9000316
Journal Paper I03-Macromolecular Crystallography
Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks Molecular Cell, 33 (2) Jan 2009 DOI: 10.1016/j.molcel.2008.12.029
Journal Paper I03-Macromolecular Crystallography
Crystallization and preliminary X-ray analysis of mouse RANK and its complex with RANKL Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65 (6) Jan 2009 DOI: 10.1107/S1744309109015735
Journal Paper I03-Macromolecular Crystallography
The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair Proceedings Of The National Academy Of Sciences, 106 (3) Jan 2009 DOI: 10.1073/pnas.0808832106
- Sachin Surade, Takashi Ochi, Daniel Nietlispach, Dima Chirgadze, Abel Moreno Carcamo, "Investigations into protein crystallization in the presence of a strong magnetic field", Crystal Growth & Design, 10 (2), 691699 (2009), DOI: 10.1021/cg901109e
- Mark W. Richards, Justin W. C. Leung, Junji Chen, Richard Bayliss, Mark Roe, "A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation", Journal Of Molecular Biology (2009), DOI: 10.1016/j.jmb.2009.11.029
- Rachel Bibby, Chan Tang, Amir Faisal, Konstantinos Drosopoulos, Stephen Lubbe, Richard Houlsdon, Spiros Linardopoulos, Richard Bayliss, "A cancer-associated Aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2", Journal Of Biological Chemistry (2009), DOI: 10.1074/jbc.M109.032722
- Nathan A. Lack, Katherine C. Yam, Edward D. Lowe, Geoff P. Horsman, Robin L. Owen, Edith Sim, Lindsay D. Eltis, "Characterization of a C-C hydrolase from Mycobacterium tuberuclosis involved in cholesterol metabolism", Journal Of Biological Chemistry (2009), DOI: 10.1074/jbc.M109.058081
- Kirsty J. Mclean, Pierre Lafite, Myles R. Cheesman, Nathalia Mast, Irina A. Pikuleva, Andrew W. Munro, Colin Levy, David Leys, "The structure of Mycobacterium tuberculosis CYP125: Molecular basis for cholesterol binding in a P450 needed for host infection", Journal Of Biological Chemistry (2009), DOI: 10.1074/jbc.M109.032706
- Duncan E. Scott, Gwen J. Dawes, Michiyo Ando, Chris Abell, Alessio Ciulli, "A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry", Chembiochem, 10 (17), 2772-9 (2009), DOI: 10.1002/cbic.200900537
- Huw T. Jenkins, Rosanna Baker-Wilding, Thomas A. Edwards, "Structure and RNA binding of the mouse Pumilio-2 Puf domain", Journal Of Structural Biology, 167 (3), 271-6 (2009), DOI: 10.1016/j.jsb.2009.06.007
- Jody A. Winter, Panayiotis Christofi, Shaun Morroll, Karen A. Bunting, "The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation", Bmc Structural Biology, 9 (55) (2009), DOI: 10.1186/1472-6807-9-55
- Kian Hoe Khoo, Stefan M. V. Freund, Alan R. Fersht, Andreas C. Joerger, "Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core", Protein Engineering, Design And Selection, 22 (7), 421 - 30 (2009), DOI: 10.1093/protein/gzp018
- Olga Mayans, Miriam Deuss, Marc Bruning, Andreas Ivens, Thomas Schwab, Nadja Hellmann, Reinhard Sterner, "Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release", Biochemistry, 48 (23), 5199 - 5209 (2009), DOI: 10.1021/bi802335s
- J.-J. Zhou, G. Robertson, X. He, S. Dufour, A. M. Hooper, J. A. Pickett, L. M. Field, N. H. Keep, "Characterisation of Bombyx mori Odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components", Journal Of Molecular Biology, 389 (3), 529-45 (2009), DOI: 10.1016/j.jmb.2009.04.015
- B. Bishop, Karl Harlos, C. A. O'Callaghan, E. Y. Jones, Christian Siebold, Alexandru Aricescu, "Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP", Nature Structural & Molecular Biology, 16 (7), 698 - 703 (2009), DOI: 10.1038/nsmb.1607
- Maria Harkiolaki, Theodora Tsirka, Marc Lewitzky, Philip C. Simister, Dhira Joshi, Louise E. Bird, E. Yvonne Jones, Nicola O'Reilly , Stephen M. Feller, "Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2", Structure , 17 (6), 809-822 (2009), DOI: 10.1016/j.str.2009.03.017
- G. Jubelin, Carolina Varela Chavez, Jean-Michel Escoubas, Eric Oswald, Mark J. Banfield, Allister Crow, Paul R. Race, "Crystal structures of Cif from bacterial pathogens Photorhabdus luminescens and Burkholderia pseudomallei", Plos One (2009), DOI: 10.1371/journal.pone.0005582
- Mark A. Stead, Stephen B. Carr, Stephanie C. Wright, "Structure of the human Nac1 POZ domain", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65, 445 - 449 (2009), DOI: 10.1107/S1744309109012214
- Matthew Davies, Timo Heikkila, Glenn A. Mcconkey, Colin W. G. Fishwick, Mark R. Parsons, A. Peter Johnson, "Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases", Journal Of Medicinal Chemistry, 52 (9), 2683 - 2693 (2009), DOI: 10.1021/jm800963t
- Arwen R. Pearson, Simon E. V. Phillips, Michael J. Mcpherson, Didem Sutay Kocabas, Ufuk Bakir, Zumrut B. Ogel, Chi H. Trinh, "Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65, 486-488 (2009), DOI: 10.1107/S1744309109012007
- Ivan Laponogov, Maninder K Sohi, Dennis A Veselkov, Xiao-Su Pan, Ritica Sawhney, Andrew W. Thompson, Katherine Mcauley, L. Mark Fisher, Mark R. Sanderson, "Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases", Nature Structural & Molecular Biology, 16 (6), 667 - 669 (2009), DOI: 10.1038/nsmb.1604
- Kathrin Schirner, Jeff Errington, Richard J. Lewis, Jon Marles-Wright, "Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis", The Embo Journal, 28 (7), 830-42 (2009), DOI: 10.1038/emboj.2009.25
- Bibek Gooptu, Elena Miranda, Irene Nobeli, Meera Mallya, Andrew Purkiss, Sarah C. Leigh Brown, Charlotte Summers, Russell L. Phillips, David A. Lomas, Tracey Barrett, "Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of α1-antitrypsin: implications for disease and drug design", Journal Of Molecular Biology, 387 (4), 857 - 868 (2009), DOI: 10.1016/j.jmb.2009.01.069
- Katsuko Sako, Chan Li, Isabelle Salard, Andrew Thompson, Christopher Dennison, Mark J. Banfield, "Metal-binding loop length and not sequence dictates structure", Proceedings Of The National Academy Of Sciences, 106 (14), 5616-5621 (2009), DOI: 10.1073/pnas.0811324106
- Cecile M. Tron, Iain W. Mcnae, Margeret Nutley, David J. Clarke, Alan Cooper, Malcolm D. Walkinshaw, Robert L. Baxter, Dominic J. Campopiano, "Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity", Journal Of Molecular Biology, 387(1), 129-46 (2009), DOI: 10.1016/j.jmb.2008.12.086
- Julia Richardson, Lesley S. Morrison, Nicholas D. Bland, Sandra Bruce, Graham H. Coombs, Jeremy C. Mottram, Malcolm D. Walkinshaw, "Structures of Leishmania major orthologues of macrophage migration inhibitory factor", Biochemical And Biophysical Research Communications, 380 (3), 442 - 448 (2009), DOI: 10.1016/j.bbrc.2009.01.030
- Paul R. Race, Matthew L . Bentley, Jeff A. Melvin, Allister Crow, Richard K. Hughes, Wendy D. Smith, Richard B. Sessions, Michael A. Kehoe, Dewey G. Mccafferty, Mark J. Banfield, "Crystal structure of Streptococcus pyogenes Sortase A: Implications for sortase mechanism", Journal Of Biological Chemistry, 284 (11), 6924-6933 (2009), DOI: 10.1074/jbc.M805406200
- Cedric Montanier, Alicia Lammerts Van Bueren, Claire Dumon, James E. Flint, Márcia Correia, Jose A. Prates, Susan Firbank, Rick Lewis, Gilles G. Grondin, Mariana G. Ghinet, Tracey M. Gloster, Cecile Herve, J. Paul Knox, Brian G. Talbot, Johan P. Turkenburg, Janne Kerovuo, Ryszard Brzezinski, Carlos M. G. A. Fontes, Gideon J. Davies, Alisdair B. Boraston, Harry J. Gilbert, "Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function", Proceedings Of The National Academy Of Sciences, 106 (9), 3065 - 3070 (2009), DOI: 10.1073/pnas.0808972106
- Muriel C. Schneider, Beverly E. Prosser, Joseph J. E. Caesar, Elisabeth Kugelberg, Su Li, Qian Zhang, Sadik Quoraishi, Janet E. Lovett, Janet E. Deane, Robert B. Sim, Pietro Roversi, Steven Johnson, Christoph M. Tang, Susan M. Lea, "Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates", Nature, 458, 890-893 (2009), DOI: 10.1038/nature07769
- Geoffrey Masuyer, Nethaji Thiyagarajan, Peter L. James, Philip M. H. Marks, John A. Chaddock, K. Ravi Acharya, "Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A", Biochemical And Biophysical Research Communications, 381 (1), 50-53 (2009), DOI: 10.1016/j.bbrc.2009.02.003
- Duo Lu, Mirka E. Wormann, Xiaodong Zhang, Olaf Schneewind , Angelika Grundling, Paul S. Freemont, "Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS", Proceedings Of The National Academy Of Sciences, 106 (5), 1584-9 (2009), DOI: 10.1073/pnas.0809020106
- Isaac Westwood, Donna-Marie Cheary, Joanne Baxter, Mark W. Richards, Rob L. M. Van Montfort, Andrew M. Fry, Richard Bayliss, "Insights into the conformational variability and regulation of human Nek2 kinase", Journal Of Molecular Biology, 386 (2), 476-485 (2009), DOI: 10.1016/j.jmb.2008.12.033
- Chrisostomos Prodromou, James M. Nuttall, Stefan H. Millson, Tiow-Suan Sim, Doreen Tan, Paul Workman, Laurence H. Pearl, Peter W. Piper, S. Mark Roe, "Structural basis of the radicicol resistance displayed by a fungal Hsp90", Acs Chemical Biology, 4 (4), 289297 (2009), DOI: 10.1021/cb9000316
- Stacey M. Southall, Poon-Sheng Wong, Zain Odho, Jon R. Wilson, S. Mark Roe, "Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks", Molecular Cell, 33 (2), 181-191 (2009), DOI: 10.1016/j.molcel.2008.12.029
- Thomas S. Walter, Changzhen Liu, Peng Huang, Shiqian Zhang, Lucy R. Wedderburn, Bin Gao, Raymond J. Owens, Peifu Tang Tang, Jingshan Ren, David I. Stuart, "Crystallization and preliminary X-ray analysis of mouse RANK and its complex with RANKL", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65 (6), 597-600 (2009), DOI: 10.1107/S1744309109015735
- P. C. Fineran, T. R. Blower, I. J. Foulds, D. P. Humphreys, K. S. Lilley, G. P. C. Salmond, "The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair", Proceedings Of The National Academy Of Sciences, 106 (3), 894 - 899 (2009), DOI: 10.1073/pnas.0808832106
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