Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I03 Contact
Beamline Phone Number:
+44 (0) 1235 778707
Acting Principal Beamline Scientist:
Dave Hall
Tel: +44 (0) 1235 778926
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I03 MX
Status: Operational
Beamsize: 90 µm x 20 µm
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
These publications are based on data gathered on beamline I03. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
143 items found for 2015 [total: 2353]
Redox signaling by the rna polymerase III TFIIB-related factor Brf2 Cell, 163 (6) Dec 2015 DOI: 10.1016/j.cell.2015.11.005
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Nuclear factor 90 uses an ADAR2-like binding mode to recognize specific bases in dsRNA Nucleic Acids Research, Dec 2015 DOI: 10.1093/nar/gkv1508
Comparison of the structure and activity of glycosylated and aglycosylated human carboxylesterase 1 Plos One, 10 Dec 2015 DOI: 10.1371/journal.pone.0143919
Crystal structure of the measles virus nucleoprotein core in complex with an n-terminal region of phosphoprotein Journal Of Virology, Dec 2015 DOI: 10.1128/JVI.02865-15
Journal Paper I03-Macromolecular Crystallography
Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus Nature Communications, 6 Dec 2015 DOI: 10.1038/ncomms9884
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology- mediated end-joining pathway Structure, 23 (12) Dec 2015 DOI: 10.1016/j.str.2015.10.014
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structural and spectroscopic characterisation of a heme peroxidase from sorghum Jbic Journal Of Biological Inorganic Chemistry, Dec 2015 DOI: 10.1007/s00775-015-1313-z
Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53 Structure, 23 (12) Dec 2015 DOI: 10.1016/j.str.2015.10.016
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Detection of secondary binding sites in proteins using fragment screening Proceedings Of The National Academy Of Sciences, 112 Dec 2015 DOI: 10.1073/pnas.1518946112
Journal Paper I03-Macromolecular Crystallography
Unraveling the B. pseudomalleiheptokinase WcbL: from structure to drug discovery Chemistry & Biology, 22 Dec 2015 DOI: 10.1016/j.chembiol.2015.10.015
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin Nature Communications, 6 Dec 2015 DOI: 10.1038/ncomms10048
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Crystal structure of a eukaryotic GEN1 resolving enzyme bound to DNA Cell Reports, 13 Dec 2015 DOI: 10.1016/j.celrep.2015.11.042
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family Nature Communications, 6 Dec 2015 DOI: 10.1038/ncomms10197
Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis Cancer Research, Dec 2015 DOI: 10.1158/0008-5472.CAN-15-0701-T
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Human ISPD is a cytidyltransferase required for dystroglycan o-mannosylation Chemistry & Biology, 22 Dec 2015 DOI: 10.1016/j.chembiol.2015.10.014
Journal Paper I03-Macromolecular Crystallography
Structural studies of alpha2 macroglobulin from Limulus polyphemus Dec 2015
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance Science Advances, 1 Nov 2015 DOI: 10.1126/sciadv.1500723
Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization Nature Communications, 6 Nov 2015 DOI: 10.1038/ncomms9771
Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site Bioscience Reports, 35 Nov 2015 DOI: 10.1042/BSR20150183
Application of in situ diffraction in high-throughput structure determination platforms Methods In Molecular Biology, 1261 Nov 2015 DOI: 10.1007/978-1-4939-2230-7_13
Book Chapter I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains Dna Repair, 35 Nov 2015 DOI: 10.1016/j.dnarep.2015.10.002
A long-lived FeIII-(hydroperoxo) intermediate in the active H200C variant of homoprotocatechuate 2,3-dioxygenase: characterization by Mössbauer, electron paramagnetic resonance, and density functional theory methods Inorganic Chemistry, 54 (21) Nov 2015 DOI: 10.1021/acs.inorgchem.5b01576
Journal Paper I03-Macromolecular Crystallography
Structure of the bacterial cell division determinant GpsB and its interaction with penicillin binding proteins Molecular Microbiology, Nov 2015 DOI: 10.1111/mmi.13279
Structural determinants of reductive terpene cyclization in iridoid biosynthesis Nature Chemical Biology, Nov 2015 DOI: 10.1038/nchembio.1955
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
X-ray structure and activities of an essential Mononegavirales L-protein domain Nature Communications, 6 Nov 2015 DOI: 10.1038/ncomms9749
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for the binding of tryptophan-based motifs by δ-COP Proceedings Of The National Academy Of Sciences, Nov 2015 DOI: 10.1073/pnas.1506186112
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Development of small-molecule Trypanosoma brucei n-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode Chemmedchem, 10 Nov 2015 DOI: 10.1002/cmdc.201500301
The angiotensin-converting enzyme cleavage of the Alzheimer’s beta-amyloid peptide Nov 2015
Thesis I03-Macromolecular Crystallography
A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct Oncotarget, Nov 2015 DOI: 10.18632/oncotarget.11511
Structural characterization of human heparanase reveals insights into substrate recognition Nature Structural & Molecular Biology, 22 Nov 2015 DOI: 10.1038/nsmb.3136
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII Immunological Reviews, 268 Nov 2015 DOI: 10.1111/imr.12340
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Development of crystallographic techniques and their application to several protein targets Nov 2015
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure of a catalytic dimer of the α- and β-subunits of the F-ATPase from Acta Crystallographica Section F Structural Biology Communications, 71 Oct 2015 DOI: 10.1107/S2053230X15016076
Structure elucidation of coxsackievirus A16 in complex with GPP3 informs a systematic review of highly potent capsid binders to enteroviruses Plos Pathogens, 11 (10) Oct 2015 DOI: 10.1371/journal.ppat.1005165
Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy Nature Chemistry, Oct 2015 DOI: 10.1038/nchem.2369
Structure and function of Caulobacter crescentus aldose–aldose oxidoreductase Biochemical Journal, 472 Oct 2015 DOI: 10.1042/BJ20150681
Journal Paper I03-Macromolecular Crystallography
Comprehensive characterization of the Published Kinase Inhibitor Set Nature Biotechnology, Oct 2015 DOI: 10.1038/nbt.3374
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Experimental and theoretical evaluation of the ethynyl moiety as a halogen bioisostere Acs Chemical Biology, 10 (12) Oct 2015 DOI: 10.1021/acschembio.5b00515
Discovery of azaindole ureas as a novel class of bacterial gyrase B inhibitors Journal Of Medicinal Chemistry, 58 (21) Oct 2015 DOI: 10.1021/acs.jmedchem.5b00961
Journal Paper I03-Macromolecular Crystallography
Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport Structure, 23 (10) Oct 2015 DOI: 10.1016/j.str.2015.07.016
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent Bioorganic & Medicinal Chemistry Letters, 25 (19) Oct 2015 DOI: 10.1016/j.bmcl.2015.08.003
Three aromatic residues are required for electron transfer during iron mineralization in bacterioferritin Angewandte Chemie International Edition, Oct 2015 DOI: 10.1002/anie.201507486
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Discovery and characterization of an antibody directed against exosite I of thrombin Journal Of Thrombosis And Haemostasis, Oct 2015 DOI: 10.1111/jth.13171
De novo fragment design for drug discovery and chemical biology Angewandte Chemie International Edition, Oct 2015 DOI: 10.1002/anie.201508055
Journal Paper I03-Macromolecular Crystallography
The crystal structure of pneumolysin at 2.0 Å resolution reveals the molecular packing of the pre-pore complex Scientific Reports, 5 Oct 2015 DOI: 10.1038/srep13293
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus Nature, 527 (7576) Oct 2015 DOI: 10.1038/nature15525
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural, biophysical and functional characterization of Nop7-Erb1-Ytm1 complex and its implications in eukaryotic ribosome biogenesis Oct 2015 DOI: 10.4995/Thesis/10251/55941
Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers Antimicrobial Agents And Chemotherapy, Oct 2015 DOI: 10.1128/AAC.01335-15
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Crystal structure of DIM-1, an acquired subclass B1 metallo-β-lactamase from Pseudomonas stutzeri Plos One, 10 Oct 2015 DOI: 10.1371/journal.pone.0140059
Some of the most interesting CASP11 targets through the eyes of their authors Proteins: Structure, Function, And Bioinformatics, Oct 2015 DOI: 10.1002/prot.24942
Structural insights into conformational switching in the copper metalloregulator CsoR from Acta Crystallographica Section D Biological Crystallography, 71 Sept 2015 DOI: 10.1107/S1399004715013012
Journal Paper I03-Macromolecular Crystallography
Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein Rsc Advances, 5 (95) Sept 2015 DOI: 10.1039/C5RA13552D
Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design Human Molecular Genetics, 24 (20) Sept 2015 DOI: 10.1093/hmg/ddv280
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors Scientific Reports, 5 (13397) Sept 2015 DOI: 10.1038/srep13397
Structures of coxsackievirus A16 capsids with native antigenicity: implications for particle expansion, receptor binding, and immunogenicity Journal Of Virology, 89 (20) Sept 2015 DOI: 10.1128/JVI.01102-15
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Cleavage of nicotinamide adenine dinucleotide by the ribosome-inactivating protein from Momordica charantia Acta Crystallographica Section F Structural Biology Communications, 71 (9) Sept 2015 DOI: 10.1107/S2053230X15013540
Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme Scientific Reports, 5 Sept 2015 DOI: 10.1038/srep13742
Crystal structure of insulin-regulated aminopeptidase with bound substrate analogue provides insight on antigenic epitope precursor recognition and processing The Journal Of Immunology, 195 (6) Sept 2015 DOI: 10.4049/jimmunol.1501103
Journal Paper I03-Macromolecular Crystallography
New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective bromo and extra-terminal (BET) bromodomain inhibition Journal Of Medicinal Chemistry, 59 Sept 2015 DOI: 10.1021/acs.jmedchem.5b01135
Structural basis for substrate and oxygen activation in homoprotocatechuate 2,3-dioxygenase: roles of conserved active site histidine 200 Biochemistry, 54 (34) Sept 2015 DOI: 10.1021/acs.biochem.5b00709
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Towards detailed structural understanding of α-ʟ-fucosidase: insights through X-ray crystallography and inhibitor-binding Sept 2015
Thesis I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Epoxyqueuosine reductase structure suggests a mechanism for cobalamin-dependent tRNA modification Journal Of Biological Chemistry, Sept 2015 DOI: 10.1074/jbc.M115.685693
Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors Medchemcomm, 6 (9) Sept 2015 DOI: 10.1039/C5MD00210A
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion The Journal Of Cell Biology, 210 (6) Sept 2015 DOI: 10.1083/jcb.201502078
Purification, characterization and crystallization of the F-ATPase from Open Biology, 5 (9) Sept 2015 DOI: 10.1098/rsob.150119
Molecular basis for DNA strand displacement by NHEJ repair polymerases Nucleic Acids Research, Sept 2015 DOI: 10.1093/nar/gkv965
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro Bioorganic & Medicinal Chemistry, 23 (17) Sept 2015 DOI: 10.1016/j.bmc.2015.06.061
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structure of subcomplex Iβ of mammalian respiratory complex I leads to new supernumerary subunit assignments Proceedings Of The National Academy Of Sciences, 112 Sept 2015 DOI: 10.1073/pnas.1510577112
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Characterisation of cytochrome c MtoD from the iron-oxidising autotroph Sideroxydans lithotrophicus ES-1 Sept 2015
Thesis B21-High Throughput SAXS I03-Macromolecular Crystallography
Structures of the ultra-high-affinity protein–protein complexes of pyocins S2 and AP41 and their cognate immunity proteins from Pseudomonas aeruginosa Journal Of Molecular Biology, 427 (17) Aug 2015 DOI: 10.1016/j.jmb.2015.07.014
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses Proceedings Of The National Academy Of Sciences, 112 (34) Aug 2015 DOI: 10.1073/pnas.1501956112
Differential recognition preferences of the three Src homology 3 (SH3) domains from the adaptor CD2-associated protein (CD2AP), and direct association with Ras and Rab interactor 3 (RIN3) Journal Of Biological Chemistry, Aug 2015 DOI: 10.1074/jbc.M115.637207
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development Biochemical Journal, 470 Aug 2015 DOI: 10.1042/BJ20150610
Journal Paper I03-Macromolecular Crystallography
A native ternary complex trapped in a crystal reveals the catalytic mechanism of a retaining glycosyltransferase Angewandte Chemie International Edition, 54 (34) Aug 2015 DOI: 10.1002/anie.201504617
Structures of the RNA polymerase-σ54 reveal new and conserved regulatory strategies Science, 349 (6250) Aug 2015 DOI: 10.1126/science.aab1478
Structure-based optimization of naphthyridones into potent ATAD2 bromodomain inhibitors Journal Of Medicinal Chemistry, 58 (15) Aug 2015 DOI: 10.1021/acs.jmedchem.5b00773
Journal Paper I03-Macromolecular Crystallography
Conformationally restricted calpain inhibitors Chemical Science, Aug 2015 DOI: 10.1039/C5SC01158B
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Two-step ligand binding in a (βα)8 barrel enzyme: substrate-bound structures shed new light on the catalytic cycle of HisA Journal Of Biological Chemistry, 290 Aug 2015 DOI: 10.1074/jbc.M115.678086
Modular design of self-assembling peptide-based nanotubes Journal Of The American Chemical Society, 137 (33) Aug 2015 DOI: 10.1021/jacs.5b03973
Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics Bioorganic & Medicinal Chemistry, 23 (15) Aug 2015 DOI: 10.1016/j.bmc.2015.06.063
Identification of a class of protein ADP-ribosylating sirtuins in microbial pathogens Molecular Cell, 59 (2) Jul 2015 DOI: 10.1016/j.molcel.2015.06.013
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis Annals Of The Rheumatic Diseases, Jul 2015 DOI: 10.1136/annrheumdis-2015-207656
Structure of human saposin A at lysosomal pH Acta Crystallographica Section F Structural Biology Communications, 71 (7) Jul 2015 DOI: 10.1107/S2053230X15008584
Fragment-based discovery of low-micromolar ATAD2 bromodomain inhibitors Journal Of Medicinal Chemistry, 58 (14) Jul 2015 DOI: 10.1021/acs.jmedchem.5b00772
Neuronal calcium sensor-1 binds the D2 dopamine receptor and g-protein-coupled receptor kinase 1 (GRK1) peptides using different modes of interactions Journal Of Biological Chemistry, 290 (30) Jul 2015 DOI: 10.1074/jbc.M114.627059
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan Elife, 4 Jul 2015 DOI: 10.7554/eLife.06554
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Identification of manganese superoxide dismutase from Sphingobacterium sp. T2 as a novel bacterial enzyme for lignin oxidation Acs Chemical Biology, 10 (10) Jul 2015 DOI: 10.1021/acschembio.5b00298
Journal Paper I03-Macromolecular Crystallography
Structure of protease-cleaved Escherichia coli alpha-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment Acta Crystallographica Section D Biological Crystallography, 71 (7) Jul 2015 DOI: 10.1107/S1399004715008548
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Small-molecule transport by CarO, an abundant eight-stranded β-barrel outer membrane protein from Acinetobacter baumannii Journal Of Molecular Biology, 427 (14) Jul 2015 DOI: 10.1016/j.jmb.2015.03.016
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding Chemical Science, 6 Jul 2015 DOI: 10.1039/C5SC02155C
GlxA is a new structural member of the radical copper oxidase family and is required for glycan deposition at hyphal tips and morphogenesis of Streptomyces lividans Biochemical Journal, June 2015 DOI: 10.1042/BJ20150190
Journal Paper I03-Macromolecular Crystallography
In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 a-Lfucosidases Chemical Science, 6 (5) June 2015 DOI: 10.1039/C4SC03739A
Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes Embo Reports, 16 (7) June 2015 DOI: 10.15252/embr.201540229
Expression, purification, crystallization and preliminary X-ray analysis of CttA, a putative cellulose-binding protein from Ruminococcus flavefaciens Acta Crystallographica Section F Structural Biology Communications, 71 June 2015 DOI: 10.1107/S2053230X15008249
Journal Paper I03-Macromolecular Crystallography
Structural basis for the specificity of human NUDT16 and its regulation by inosine monophosphate Plos One, 10 (6) June 2015 DOI: 10.1371/journal.pone.0131507
Outer-membrane translocation of bulky small molecules by passive diffusion Proceedings Of The National Academy Of Sciences, 112 (23) June 2015 DOI: 10.1073/pnas.1424835112
Regulation of endoplasmic reticulum turnover by selective autophagy Nature, 522 (7556) June 2015 DOI: 10.1038/nature14498
Journal Paper I03-Macromolecular Crystallography
Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies Molecular Biosystems, 11 June 2015 DOI: 10.1039/C5MB00284B
A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterisation Chembiochem, May 2015 DOI: 10.1002/cbic.201500185
The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies Elife, 4 May 2015 DOI: 10.7554/eLife.07236
The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation Elife, 4 May 2015 DOI: 10.7554/eLife.07410
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structural studies of a thermophilic esterase from a new Planctomycetes species, Thermogutta terrifontis Febs Journal, 282 (15) May 2015 DOI: 10.1111/febs.13326
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Discovery and characterisation of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries Febs Journal, 282 (15) May 2015 DOI: 10.1111/febs.13328
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein Nature Structural & Molecular Biology, 22 (6) May 2015 DOI: 10.1038/nsmb.3016
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation Nature Communications, 6 May 2015 DOI: 10.1038/ncomms7937
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Unraveling the specific regulation of the central pathway for anaerobic degradation of 3-methylbenzoate Journal Of Biological Chemistry, 290 (19) May 2015 DOI: 10.1074/jbc.M115.637074
The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly Acta Crystallographica Section F Structural Biology Communications, 71 (5) May 2015 DOI: 10.1107/S2053230X15000990
Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline Chembiochem, 16 May 2015 DOI: 10.1002/cbic.201402625
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes Chemical Science, 6 (6) Apr 2015 DOI: 10.1039/C5SC00913H
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Characterization of MtoD from Sideroxydans lithotrophicus: a cytochrome c electron shuttle used in lithoautotrophic growth Frontiers In Microbiology, 6 Apr 2015 DOI: 10.3389/fmicb.2015.00332
Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding Elife, 4 Apr 2015 DOI: 10.7554/eLife.05345
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structures of the Ets protein DNA-binding domains of transcription factors Etv1, Etv4, Etv5, and Fev: determinants of DNA binding and redox regulation by disulfide bond formation Journal Of Biological Chemistry, Apr 2015 DOI: 10.1074/jbc.M115.646737
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
CALM Regulates Clathrin-Coated Vesicle Size and Maturation by Directly Sensing and Driving Membrane Curvature Developmental Cell, 33 Apr 2015 DOI: 10.1016/j.devcel.2015.03.002
The carboxy-terminal domain of Erb1 is a seven-bladed ß-propeller that binds RNA Plos One, 10 Apr 2015 DOI: 10.1371/journal.pone.0123463
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Cell-surface attachment of bacterial multienzyme complexes involves highly dynamic protein-protein anchors Journal Of Biological Chemistry, 290 (21) Apr 2015 DOI: 10.1074/jbc.M114.633339
Mechanism of thiosulfate oxidation in the SoxA family of cysteine-ligated cytochromes Journal Of Biological Chemistry, 290 (14) Apr 2015 DOI: 10.1074/jbc.M114.618025
Assembly and specific recognition of K29- and K33-linked polyubiquitin Molecular Cell, Mar 2015 DOI: 10.1016/j.molcel.2015.01.042
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases Elife, 4 Mar 2015 DOI: 10.7554/eLife.04871
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
The effect of mutations on drug sensitivity and kinase activity of fibroblast growth factor receptors: a combined experimental and theoretical study Ebiomedicine, 2 (3) Mar 2015 DOI: 10.1016/j.ebiom.2015.02.009
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein Journal Of Biological Chemistry, 290 (12) Mar 2015 DOI: 10.1074/jbc.M114.630160
Improved crystallization and diffraction of caffeine-induced death suppressor protein 1 (Cid1) Acta Crystallographica Section F Structural Biology Communications, 71 (3) Mar 2015 DOI: 10.1107/S2053230X15001351
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Evidence for a boat conformation at the transition state of GH76 α-1,6-mannanases--key enzymes in bacterial and fungal mannoprotein metabolism Angewandte Chemie International Edition, Mar 2015 DOI: 10.1002/anie.201410502
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Yersinia effector YopO uses actin as bait to phosphorylate proteins that regulate actin polymerization Nature Structural & Molecular Biology, 22 (3) Feb 2015 DOI: 10.1038/nsmb.2964
Journal Paper I03-Macromolecular Crystallography
The structure of the dynactin complex and its interaction with dynein Science, Feb 2015 DOI: 10.1126/science.aaa4080
Journal Paper I03-Macromolecular Crystallography
A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape Retrovirology, 12 Feb 2015 DOI: 10.1186/s12977-015-0149-5
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure determination of Murine Norovirus NS6 proteases with C-terminal extensions designed to probe protease–substrate interactions Peerj, 3 Feb 2015 DOI: 10.7717/peerj.798
Structural insight in the inhibition of adherence of F4 fimbriae producing enterotoxigenic Escherichia coli by llama single domain antibodies Veterinary Research, 46 Feb 2015 DOI: 10.1186/s13567-015-0151-x
Structural role of the flanking DNA in mariner transposon excision Nucleic Acids Research, 43 (4) Feb 2015 DOI: 10.1093/nar/gkv096
Notum deacylates Wnt proteins to suppress signalling activity Nature, 519 (7542) Feb 2015 DOI: 10.1038/nature14259
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis The Embo Journal, 34 Feb 2015 DOI: 10.15252/embj.201489847
Structure of the GH76 α-mannanase homolog, BT2949, from the gut symbiont Bacteroides thetaiotaomicron Acta Crystallographica Section D Biological Crystallography, 71 Feb 2015 DOI: 10.1107/S1399004714026443
Crystallization and preliminary crystallographic analysis of the putative sugar-binding protein Msmeg_0515 (AgaE) from Acta Crystallographica Section F Structural Biology Communications, 71 Feb 2015 DOI: 10.1107/S2053230X15000035
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Human Δ3, D2-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role ot its ACBP domain and helix-10 Febs Journal, 282 (4) Feb 2015 DOI: 10.1111/febs.13179
Journal Paper I03-Macromolecular Crystallography
X-ray crystallographic and EPR spectroscopic analysis of HydG, a maturase in [FeFe]-hydrogenase H-cluster assembly Proceedings Of The National Academy Of Sciences, 112 (5) Feb 2015 DOI: 10.1073/pnas.1417252112
Journal Paper I03-Macromolecular Crystallography
Structural basis of multivalent galactose-based dendrimer recognition by human galectin-7 Febs Journal, 282 (2) Jan 2015 DOI: 10.1111/febs.13140
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Exploiting the hydrophobic terrain in fucosidases with aryl-substituted pyrrolidine iminosugars Chembiochem, 16 (2) Jan 2015 DOI: 10.1002/cbic.201402509
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structural and kinetic dissection of the endo -α-1,2-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp. Chemistry - A European Journal, 21 (5) Jan 2015 DOI: 10.1002/chem.201405539
Journal Paper I03-Macromolecular Crystallography
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism Nature, 517 (7533) Jan 2015 DOI: 10.1038/nature13995
Journal Paper I03-Macromolecular Crystallography
The three-dimensional structure of the cellobiohydrolase Cel7A from Aspergillus fumigatus at 1.5 Å resolution Acta Crystallographica Section F Structural Biology Communications, 71 Jan 2015 DOI: 10.1107/S2053230X14027307
PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair Science, 347 (6218) Jan 2015 DOI: 10.1126/science.1261971
Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition Elife, 4 Jan 2015 DOI: 10.7554/eLife.04986
Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates Epigenetics, 9 (12) Jan 2015 DOI: 10.4161/15592294.2014.983381
Understanding cell signalling systems: paving the way for new therapies Philosophical Transactions Of The Royal Society A: Mathematical, Physical And Engineering Sciences, 373 Jan 2015 DOI: 10.1098/rsta.2013.0155
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
- Jerome Gouge, Karishma Satia, Nicolas Guthertz, Marcella Widya, Andrew james Thompson, Pascal Cousin, Oleksandr Dergai, Nouria Hernandez, Alessandro Vannini, "Redox signaling by the rna polymerase III TFIIB-related factor Brf2", Cell, 163 (6), 1375 - 1387 (2015), DOI: 10.1016/j.cell.2015.11.005
- Uma Jayachandran, Heather Grey, Atlanta G Cook, "Nuclear factor 90 uses an ADAR2-like binding mode to recognize specific bases in dsRNA", Nucleic Acids Research (2015), DOI: 10.1093/nar/gkv1508
- Victoria Arena De Souza, David J. Scott, Joanne E. Nettleship, Nahid Rahman, Michael H. Charlton, Martin Walsh, Raymond J. Owens, "Comparison of the structure and activity of glycosylated and aglycosylated human carboxylesterase 1", Plos One, 10 (2015), DOI: 10.1371/journal.pone.0143919
- Sergey G. Guryanov, Lassi Liljeroos, Prasad Kasaragod, Tommi Kajander, Sarah Butcher, "Crystal structure of the measles virus nucleoprotein core in complex with an n-terminal region of phosphoprotein", Journal Of Virology (2015), DOI: 10.1128/JVI.02865-15
- Carey Lambert, Ian T. Cadby, Rob Till, Nhat Khai Bui, Thomas R. Lerner, William S. Hughes, David J. Lee, Luke J. Alderwick, Waldemar Vollmer, Elizabeth R. Sockett, Andrew L. Lovering, "Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus", Nature Communications, 6 (2015), DOI: 10.1038/ncomms9884
- Joseph A. Newman, Christopher D. O. Cooper, Hazel Aitkenhead, Opher Gileadi, "Structure of the helicase domain of DNA polymerase theta reveals a possible role in the microhomology- mediated end-joining pathway", Structure, 23 (12), 2319 - 2330 (2015), DOI: 10.1016/j.str.2015.10.014
- Chukwudi I. Nnamchi, Gary Parkin, Igor Efimov, Jaswir Basran, Hanna Kwon, Dimitri A. Svistunenko, Jon Agirre, Bartholomew N. Okolo, Anene Moneke, Bennett C. Nwanguma, Peter Moody, Emma L. Raven, "Structural and spectroscopic characterisation of a heme peroxidase from sorghum", Jbic Journal Of Biological Inorganic Chemistry (2015), DOI: 10.1007/s00775-015-1313-z
- Andreas C. Joerger, Matthias R. Bauer, Rainer Wilcken, Matthias G. J. Baud, Hannes Harbrecht, Thomas E. Exner, Frank M. Boeckler, John Spencer, Alan R. Fersht, "Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53", Structure, 23 (12), 2246 - 2255 (2015), DOI: 10.1016/j.str.2015.10.016
- R. Frederick Ludlow, Marcel L. Verdonk, Harpreet K. Saini, Ian J. Tickle, Harren Jhoti, "Detection of secondary binding sites in proteins using fragment screening", Proceedings Of The National Academy Of Sciences, 112, 15910 - 15915 (2015), DOI: 10.1073/pnas.1518946112
- Mirella Vivoli, Misha Isupov, Rebecca Nicholas, Andrew Hill, Andrew e. Scott, Paul Kosma, Joann l. Prior, Nicholas Harmer, "Unraveling the B. pseudomalleiheptokinase WcbL: from structure to drug discovery", Chemistry & Biology, 22, 1622 - 1632 (2015), DOI: 10.1016/j.chembiol.2015.10.015
- Pan F. Chan, Velupillai Srikannathasan, Jianzhong Huang, Haifeng Cui, Andrew P. Fosberry, Minghua Gu, Michael M. Hann, Martin Hibbs, Paul Homes, Karen Ingraham, Jason Pizzollo, Carol Shen, Anthony J. Shillings, Claus E. Spitzfaden, Robert Tanner, Andrew J. Theobald, Robert A. Stavenger, Benjamin D. Bax, Michael N. Gwynn, "Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin", Nature Communications, 6 (2015), DOI: 10.1038/ncomms10048
- Yijin Liu, Alasdair d J Freeman, Anne-Cécile Déclais, Timothy j Wilson, Anton Gartner, David Lilley, "Crystal structure of a eukaryotic GEN1 resolving enzyme bound to DNA", Cell Reports, 13, 2565 - 2575 (2015), DOI: 10.1016/j.celrep.2015.11.042
- Delu (tyler) Yin, Saioa Urresti, Mickael Lafond, Esther M. Johnston, Fatemeh Derikvand, Luisa Ciano, Jean- Guy Berrin, Bernard Henrissat, Paul Walton, Gideon Davies, Harry Brumer, "Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family", Nature Communications, 6 (2015), DOI: 10.1038/ncomms10197
- A. A. Marusiak, N. L. Stephenson, H. Baik, E. W. Trotter, Y. Li, K. Blyth, S. Mason, P. Chapman, L. A. Puto, J. A. Read, C. Brassington, H. K. Pollard, C. Phillips, I. Green, R. Overman, M. Collier, E. Testoni, C. Miller, T. Hunter, O. J. Sansom, "Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis", Cancer Research (2015), DOI: 10.1158/0008-5472.CAN-15-0701-T
- Moniek Riemersma, Sean Froese, Walinka Van tol, Udo f Engelke, Jolanta Kopec, Monique Van scherpenzeel, Angel Ashikov, Tobias Krojer, Frank Von Delft, Marco Tessari, Anna Buczkowska, Ewa Swiezewska, Lucas t Jae, Thijn r Brummelkamp, Hiroshi Manya, Tamao Endo, Hans Van bokhoven, Wyatt Yue, Dirk j Lefeber, "Human ISPD is a cytidyltransferase required for dystroglycan o-mannosylation", Chemistry & Biology, 22, 1643 - 1652 (2015), DOI: 10.1016/j.chembiol.2015.10.014
- [Thesis] Michael Nicosia, "Structural studies of alpha2 macroglobulin from Limulus polyphemus" (2015)
- O. Fedorov, J. Castex, C. Tallant Blanco, D. R. Owen, S. Martin, M. Aldeghi, O. Monteiro, P. Filippakopoulos, S. Picaud, J. D. Trzupek, B. S. Gerstenberger, C. Bountra, D. Willmann, C. Wells, M. Philpott, C. Rogers, P. C. Biggin, P. E. Brennan, M. E. Bunnage, R. Schule, Thomas Gunther, Stefan Knapp, Susanne Muller, "Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance", Science Advances, 1, e1500723 - e1500723 (2015), DOI: 10.1126/sciadv.1500723
- Tamanna Haq, Mark W. Richards, Selena G. Burgess, Pablo Gallego, Sharon Yeoh, Laura O’regan, David Reverter, Joan Roig, Andrew M. Fry, Richard Bayliss, "Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization", Nature Communications, 6 (2015), DOI: 10.1038/ncomms9771
- Jantana Wongsantichon, Robert C. Robinson, Albert J. Ketterman, "Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site", Bioscience Reports, 35, e00272 - e00272 (2015), DOI: 10.1042/BSR20150183
- [Book Chapter] Raymond J. Owens, Pierre Aller, Juan Sanchez-Weatherby, James Foadi, Graeme Winter, Carina Lobley, Danny Axford, Alun Ashton, Domenico Bellini, Jose Brandao-Neto, Simone Culurgioni, Alice Douangamath, Ramona Duman, Gwyndaf Evans, Stuart Fisher, Ralf Flaig, Dave Hall, Petra Lukacik, Marco Mazzorana, Katherine Mcauley, "Application of in situ diffraction in high-throughput structure determination platforms", Methods In Molecular Biology, 1261, 233-253 (2015), DOI: 10.1007/978-1-4939-2230-7_13
- Amy Cherry, Timothy J. Nott, Geoffrey Kelly, Stuart L. Rulten, Keith W. Caldecott, Stephen Smerdon, "Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains", Dna Repair, 35, 116 - 125 (2015), DOI: 10.1016/j.dnarep.2015.10.002
- Katlyn K. Meier, Melanie S. Rogers, Elena Kovaleva, Michael M. Mbughuni, Emile L. Bominaar, John D. Lipscomb, Eckard Münck, "A long-lived FeIII-(hydroperoxo) intermediate in the active H200C variant of homoprotocatechuate 2,3-dioxygenase: characterization by Mössbauer, electron paramagnetic resonance, and density functional theory methods", Inorganic Chemistry, 54 (21), 10269 - 10280 (2015), DOI: 10.1021/acs.inorgchem.5b01576
- Jeanine Rismondo, Robert Cleverley, Harriet Lane, Stephanie Großhennig, Anne Steglich, Lars Möller, Gopala Krishna Mannala, Torsten Hain, Richard J. Lewis, Sven Halbedel, "Structure of the bacterial cell division determinant GpsB and its interaction with penicillin binding proteins", Molecular Microbiology (2015), DOI: 10.1111/mmi.13279
- Hajo Kries, Lorenzo Caputi, Clare E M Stevenson, Mohammed O Kamileen, Nathaniel H Sherden, Fernando Geu-Flores, David Lawson, Sarah E O'Connor, "Structural determinants of reductive terpene cyclization in iridoid biosynthesis", Nature Chemical Biology (2015), DOI: 10.1038/nchembio.1955
- Guido C. Paesen, Axelle Collet, Corinne Sallamand, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard, Etienne Decroly, Jonathan M Grimes, "X-ray structure and activities of an essential Mononegavirales L-protein domain", Nature Communications, 6 (2015), DOI: 10.1038/ncomms9749
- Richard J. Suckling, Pak Phi Poon, Sophie M. Travis, Irina V. Majoul, Frederick M. Hughson, Philip R. Evans, Rainer Duden, David J. Owen, "Structural basis for the binding of tryptophan-based motifs by δ-COP", Proceedings Of The National Academy Of Sciences (2015), DOI: 10.1073/pnas.1506186112
- Daniel Spinks, Victoria Smith, Stephen Thompson, David Robinson, Torsten Luksch, Alasdair Smith, Leah S. Torrie, Stuart Mcelroy, Laste Stojanovski, Suzanne Norval, Iain T. Collie, Irene Hallyburton, Bhavya Rao, Stephen Brand, Ruth Brenk, Julie A. Frearson, Kevin D. Read, Paul G. Wyatt, Ian H. Gilbert, "Development of small-molecule Trypanosoma brucei n-myristoyltransferase inhibitors: discovery and optimisation of a novel binding mode", Chemmedchem, 10, 1821 - 1836 (2015), DOI: 10.1002/cmdc.201500301
- [Thesis] Kate Larmuth, "The angiotensin-converting enzyme cleavage of the Alzheimer’s beta-amyloid peptide" (2015)
- Cory A. Ocasio, Mohan B. Rajasekaran, Sarah Walker, Darren Le Grand, John Spencer, Frances M. G. Pearl, Simon E. Ward, Velibor Savic, Laurence H. Pearl, Helfrid Hochegger, Antony Oliver, "A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct", Oncotarget (2015), DOI: 10.18632/oncotarget.11511
- Liang Wu, Cristina M Viola, Andrzej Marek Brzozowski, Gideon J Davies, "Structural characterization of human heparanase reveals insights into substrate recognition", Nature Structural & Molecular Biology, 22, 1016 - 1022 (2015), DOI: 10.1038/nsmb.3136
- Brian J. Sutton, Anna M. Davies, "Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII", Immunological Reviews, 268, 222 - 235 (2015), DOI: 10.1111/imr.12340
- [Thesis] Sam Horrell, "Development of crystallographic techniques and their application to several protein targets" (2015)
- Edgar Morales-Rios, Martin G. Montgomery, Andrew Leslie, José J. García-Trejo, John E. Walker, "Structure of a catalytic dimer of the α- and β-subunits of the F-ATPase from", Acta Crystallographica Section F Structural Biology Communications, 71, 1309 - 1317 (2015), DOI: 10.1107/S2053230X15016076
- Luigi De Colibus, Xiangxi Wang, Aloys Tijsma, Johan Neyts, John Spyrou, Jingshan Ren, Jonathan Grimes, Gerhard Puerstinger, Pieter Leyssen, Elizabeth E. Fry, Zihe Rao, David I. Stuart, "Structure elucidation of coxsackievirus A16 in complex with GPP3 informs a systematic review of highly potent capsid binders to enteroviruses", Plos Pathogens, 11 (10) (2015), DOI: 10.1371/journal.ppat.1005165
- James P. Hall, Fergus Poynton, Paraic Keane, Sarah Gurung, John Brazier, David Cardin, Graeme Winter, Thorfinnur Gunnlaugsson, Igor V. Sazanovich, Michael Towrie, Christine J Cardin, John M. Kelly, Susan J. Quinn, "Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy", Nature Chemistry (2015), DOI: 10.1038/nchem.2369
- H Taberman, M. Andberg, A. Koivula, N. Hakulinen, M. Penttila, J. Rouvinen, T. Parkkinen, "Structure and function of Caulobacter crescentus aldose–aldose oxidoreductase", Biochemical Journal, 472, 297–307 (2015), DOI: 10.1042/BJ20150681
- Jonathan M Elkins, Vita Fedele, Marta Szklarz, Kamal R Abdul Azeez, Eidarus Salah, Jowita Mikolajczyk, Sergei Romanov, Nikolai Sepetov, Xi-Ping Huang, Bryan L Roth, Ayman Al Haj Zen, Denis Fourches, Eugene Muratov, Alex Tropsha, Joel Morris, Beverly A Teicher, Mark Kunkel, David H Drewry, William J Zuercher, Stefan Knapp, "Comprehensive characterization of the Published Kinase Inhibitor Set", Nature Biotechnology (2015), DOI: 10.1038/nbt.3374
- Rainer Wilcken, Markus O. Zimmermann, Matthias R. Bauer, Trevor J. Rutherford, Alan R. Fersht, Andreas Christian Joerger, Frank Boeckler, "Experimental and theoretical evaluation of the ethynyl moiety as a halogen bioisostere", Acs Chemical Biology, 10 (12) (2015), DOI: 10.1021/acschembio.5b00515
- Jing Zhang, Qingyi Yang, Jason B. Cross, Jan Antoinette C. Romero, Katherine M. Poutsiaka, Felix Epie, Douglas Bevan, Bin Wang, Yanzhi Zhang, Ajit Chavan, Xin Zhang, Terence Moy, Anu Daniel, Kien Nguyen, Brian Chamberlain, Nicole Carter, Joseph Shotwell, Jared Silverman, Chester A. Metcalf, Dominic Ryan, "Discovery of azaindole ureas as a novel class of bacterial gyrase B inhibitors", Journal Of Medicinal Chemistry, 58 (21), 8503 - 8512 (2015), DOI: 10.1021/acs.jmedchem.5b00961
- John Beale, Joanne Parker, Firdaus Samsudin, Anne l. Barrett, Anish Senan, Louise Bird, David Scott, Raymond Owens, Mark S. P Sansom, Stephen Tucker, David Meredith, Philip W. Fowler, Simon Newstead, "Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport", Structure, 23 (10), 1–11 (2015), DOI: 10.1016/j.str.2015.07.016
- Vassilios Bavetsias, Yolanda Pérez-Fuertes, Patrick J. Mcintyre, Butrus Atrash, Magda Kosmopoulou, Lisa O’fee, Rosemary Burke, Chongbo Sun, Amir Faisal, Katherine Bush, Sian Avery, Alan Henley, Florence I. Raynaud, Spiros Linardopoulos, Richard Bayliss, Julian Blagg, "7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent", Bioorganic & Medicinal Chemistry Letters, 25 (19), 4203 - 4209 (2015), DOI: 10.1016/j.bmcl.2015.08.003
- Justin M. Bradley, Dimitri A. Svistunenko, Tamara L. Lawson, Andrew M Hemmings, Geoffrey R. Moore, Nick Le Brun, "Three aromatic residues are required for electron transfer during iron mineralization in bacterioferritin", Angewandte Chemie International Edition (2015), DOI: 10.1002/anie.201507486
- T. P. Baglin, J. Langdown, R. Frasson, J. A. Huntington, "Discovery and characterization of an antibody directed against exosite I of thrombin", Journal Of Thrombosis And Haemostasis (2015), DOI: 10.1111/jth.13171
- Tiago Rodrigues, Daniel Reker, Martin Welin, Michael Caldera, Cyrill Brunner, Gisela Gabernet, Petra Schneider, Björn Walse, Gisbert Schneider, "De novo fragment design for drug discovery and chemical biology", Angewandte Chemie International Edition (2015), DOI: 10.1002/anie.201508055
- Jamie E. Marshall, Bayan H. A. Faraj, Alexandre R. Gingras, Rana Lonnen, Md. Arif Sheikh, Mohammed El-Mezgueldi, Peter C. E. Moody, Peter W. Andrew, Russell Wallis, "The crystal structure of pneumolysin at 2.0 Å resolution reveals the molecular packing of the pre-pore complex", Scientific Reports, 5 (2015), DOI: 10.1038/srep13293
- Narin Hengrung, Kamel El Omari, Itziar Serna Martin, Frank T. Vreede, Stephen Cusack, Robert P. Rambo, Clemens Vonrhein, Gérard Bricogne, David I. Stuart, Jonathan M. Grimes, Ervin Fodor, "Crystal structure of the RNA-dependent RNA polymerase from influenza C virus", Nature, 527 (7576), 114 - 117 (2015), DOI: 10.1038/nature15525
- [Thesis] Marcin Wegrecki, "Structural, biophysical and functional characterization of Nop7-Erb1-Ytm1 complex and its implications in eukaryotic ribosome biogenesis" (2015), DOI: 10.4995/Thesis/10251/55941
- Jurgen Brem, Sander S. Van Berkel, David Zollman, Sook Y. Lee, Opher Gileadi, Peter J. Mchugh, Timothy R. Walsh, Michael Mcdonough, Christopher J. Schofield, "Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers", Antimicrobial Agents And Chemotherapy (2015), DOI: 10.1128/AAC.01335-15
- Michael P. S. Booth, Magda Kosmopoulou, Laurent Poirel, Patrice Nordmann, James Spencer, "Crystal structure of DIM-1, an acquired subclass B1 metallo-β-lactamase from Pseudomonas stutzeri", Plos One, 10 (2015), DOI: 10.1371/journal.pone.0140059
- Andriy Kryshtafovych, John Moult, Arnaud Basle, Alex Burgin, Timothy K. Craig, Robert A. Edwards, Deborah Fass, Marcus Hartmann, Mateusz Korycinski, Rick Lewis, Donald Lorimer, Andrei N. Lupas, Janet Newman, Thomas S. Peat, Kurt H. Piepenbrink, Janani Prahlad, Mark Van Raaij, Forest Rohwer, Anca M. Segall, Victor Seguritan, Eric J. Sundberg, Abhimanyu Singh, Mark A. Wilson, Torsten Schwede, "Some of the most interesting CASP11 targets through the eyes of their authors", Proteins: Structure, Function, And Bioinformatics (2015), DOI: 10.1002/prot.24942
- T. V. Porto, M. A. Hough, J. A. R. Worrall, "Structural insights into conformational switching in the copper metalloregulator CsoR from", Acta Crystallographica Section D Biological Crystallography, 71, 1872 - 1878 (2015), DOI: 10.1107/S1399004715013012
- Samuel Reddington, Sarunas Driezis, Andrew Hartley, Peter D. Watson, Pierre J. Rizkallah, Dafydd Jones, "Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein", Rsc Advances, 5 (95), 77734 - 77738 (2015), DOI: 10.1039/C5RA13552D
- Sean Froese, Amit Michaeli, Thomas Mccorvie, Tobias Krojer, Meitav Sasi, Esther Melaev, Amiram Goldblum, Maria Zatsepin, Alexander Lossos, Rafael Álvarez, Pablo V. Escribá, Berge A. Minassian, Frank Von Delft, Or Kakhlon, Wyatt Yue, "Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design", Human Molecular Genetics, 24 (20), 5667 - 5676 (2015), DOI: 10.1093/hmg/ddv280
- Geoffrey Masuyer, Jonathan R. Davies, Kevin Moore, John A. Chaddock, K. Ravi Acharya, "Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors", Scientific Reports, 5 (13397) (2015), DOI: 10.1038/srep13397
- Jingshan Ren, Xiangxi Wang, Ling Zhu, Zhongyu Hu, Qiang Gao, Pan Yang, Xuemei Li, Junzhi Wang, Xinliang Shen, Elizabeth Fry, Zihe Rao, Dave Stuart, K. Kirkegaard, "Structures of coxsackievirus A16 capsids with native antigenicity: implications for particle expansion, receptor binding, and immunogenicity", Journal Of Virology, 89 (20), 10500 - 10511 (2015), DOI: 10.1128/JVI.01102-15
- M. Vinkovic, G. Dunn, G. E. Wood, J. Husain, S. P. Wood, R. Gill, "Cleavage of nicotinamide adenine dinucleotide by the ribosome-inactivating protein from Momordica charantia", Acta Crystallographica Section F Structural Biology Communications, 71 (9), 1152 - 1155 (2015), DOI: 10.1107/S2053230X15013540
- Geoffrey Masuyer, Ross G. Douglas, Edward D. Sturrock, K. Ravi Acharya, "Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme", Scientific Reports, 5 (2015), DOI: 10.1038/srep13742
- A. Mpakali, E. Saridakis, K. Harlos, Y. Zhao, A. Papakyriakou, P. Kokkala, D. Georgiadis, E. Stratikos, "Crystal structure of insulin-regulated aminopeptidase with bound substrate analogue provides insight on antigenic epitope precursor recognition and processing", The Journal Of Immunology, 195 (6), 2842 - 2851 (2015), DOI: 10.4049/jimmunol.1501103
- Matthias G. J. Baud, Enrique Lin-Shiao, Michael Zengerle, Cynthia Tallant, Alessio Ciulli, "New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective bromo and extra-terminal (BET) bromodomain inhibition", Journal Of Medicinal Chemistry, 59, 1492–1500 (2015), DOI: 10.1021/acs.jmedchem.5b01135
- Elena G. Kovaleva, Melanie S. Rogers, John D. Lipscomb, "Structural basis for substrate and oxygen activation in homoprotocatechuate 2,3-dioxygenase: roles of conserved active site histidine 200", Biochemistry, 54 (34), 5329 - 5339 (2015), DOI: 10.1021/acs.biochem.5b00709
- [Thesis] Daniel Wayne Wright, "Towards detailed structural understanding of α-ʟ-fucosidase: insights through X-ray crystallography and inhibitor-binding" (2015)
- Karl Payne, Karl Fisher, Hanno Sjuts, Mark Dunstan, Bruno Bellina, Linus Johannissen, Perdita Barran, Sam Hay, Stephen E.j. Rigby, David Leys, "Epoxyqueuosine reductase structure suggests a mechanism for cobalamin-dependent tRNA modification", Journal Of Biological Chemistry (2015), DOI: 10.1074/jbc.M115.685693
- Richard J. R. Elliott, Ashley Jarvis, Mohan B. Rajasekaran, Malini Menon, Leandra Bowers, Ray Boffey, Melanie Bayford, Stuart Firth-Clark, Rebekah Key, Rehan Aqil, Stewart B. Kirton, Dan Niculescu-Duvaz, Laura Fish, Filipa Lopes, Robert Mcleary, Ines Trindade, Elisenda Vendrell, Felix Munkonge, Alan Ashworth, Christopher Lord, "Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors", Medchemcomm, 6 (9), 1687 - 1692 (2015), DOI: 10.1039/C5MD00210A
- L. Yan, S. Sun, W. Wang, J. Shi, X. Hu, S. Wang, D. Su, Z. Rao, J. Hu, Z. Lou, "Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion", The Journal Of Cell Biology, 210 (6), 961 - 972 (2015), DOI: 10.1083/jcb.201502078
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