Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I03 Contact
Beamline Phone Number:
+44 (0) 1235 778707
Acting Principal Beamline Scientist:
Dave Hall
Tel: +44 (0) 1235 778926
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I03 MX
Status: Operational
Beamsize: 90 µm x 20 µm
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
These publications are based on data gathered on beamline I03. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
118 items found for 2013 [total: 2353]
Conformational plasticity at the IgE-binding site of the B-cell receptor CD23 Molecular Immunology, 56 (4) Dec 2013 DOI: 10.1016/j.molimm.2013.07.005
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Complementary studies of the role of metals in the conformation and interactions of serum amyloid P component and β-amyloid Aβ42 Dec 2013
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural basis of AMPK regulation by small molecule activators Nature Communications, 4 Dec 2013 DOI: 10.1038/ncomms4017
Two high-resolution structures of the human E3 ubiquitin ligase Siah1 Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Dec 2013 DOI: 10.1107/S1744309113031448
Structural basis of lentiviral subversion of a cellular protein degradation pathway Nature, 505 (7482) Dec 2013 DOI: 10.1038/nature12815
Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens Acta Crystallographica Section D Biological Crystallography, 69 Dec 2013 DOI: 10.1107/S0907444913022725
The cyanobactin heterocyclase enzyme: a processive adenylase that operates with a defined order of reaction† Angewandte Chemie International Edition, 52 (52) Dec 2013 DOI: 10.1002/anie.201306302
Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay Biochemistry, 52 (51) Dec 2013 DOI: 10.1021/bi400945y
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Changes in the hemagglutinin of H5N1 viruses during human infection – Influence on receptor binding Virology, 447 (1) Dec 2013 DOI: 10.1016/j.virol.2013.08.010
Structural analysis uncovers lipid-binding properties of notch ligands Cell Reports, 5 (4) Nov 2013 DOI: 10.1016/j.celrep.2013.10.029
Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre Molecular Microbiology, Nov 2013 DOI: 10.1111/mmi.12447
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells Journal Of Medicinal Chemistry, 56 (22) Nov 2013 DOI: 10.1021/jm401115g
Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme Febs Journal, Nov 2013 DOI: 10.1111/febs.12660
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Syntaxin binding mechanism and disease-causing mutations in Munc18-2 Proceedings Of The National Academy Of Sciences, 110 (47) Nov 2013 DOI: 10.1073/pnas.1313474110
Structure and assembly of an inner membrane platform for initiation of type IV pilus biogenesis Proceedings Of The National Academy Of Sciences, Nov 2013 DOI: 10.1073/pnas.1312313110
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin Nature Communications, 4 Nov 2013 DOI: 10.1038/ncomms3787
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural determinants of unique properties of human IgG4-Fc Journal Of Molecular Biology, Nov 2013 DOI: 10.1016/j.jmb.2013.10.039
The molecular recognition of kink-turn structure by the L7Ae class of proteins Rna, 19 (12) Nov 2013 DOI: 10.1261/rna.041517.113
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and genetic analyses reveal the protein SepF as a new membrane anchor for the Z ring Proceedings Of The National Academy Of Sciences, 110 (48) Nov 2013 DOI: 10.1073/pnas.1313978110
Exploring a multivalent approach to α‐L‐fucosidase inhibition European Journal Of Organic Chemistry, 2013 Nov 2013 DOI: 10.1002/ejoc.201300878
Journal Paper I03-Macromolecular Crystallography
The X-ray crystal structure of APR-B, an atypical adenosine 5′-phosphosulfate reductase from Physcomitrella patens Febs Letters, Oct 2013 DOI: 10.1016/j.febslet.2013.09.034
Journal Paper I03-Macromolecular Crystallography
Functional and structural characterisation of a viral cytochrome b5 Febs Letters, 587 (22) Oct 2013 DOI: 10.1016/j.febslet.2013.09.035
Journal Paper I03-Macromolecular Crystallography
Mutations of an NAD(P)H-dependent flavoprotein monooxygenase that influence cofactor promiscuity and enantioselectivity Febs Open Bio, Oct 2013 DOI: 10.1016/j.fob.2013.09.008
Structure of Cu(I)-bound DJ-1 reveals a biscysteinate metal binding site at the homodimer interface: insights into mutational inactivation of DJ-1 in Parkinsonism Journal Of The American Chemical Society, 135 (43) Oct 2013 DOI: 10.1021/ja406010m
Structure of a bifunctional alcohol dehydrogenase involved in bioethanol generation in Geobacillus thermoglucosidasius Acta Crystallographica Section D Biological Crystallography, 69 Oct 2013 DOI: 10.1107/S0907444913020349
Journal Paper I03-Macromolecular Crystallography
The hydrogen peroxide induced radical behaviour in human cytochrome c phospholipid complexes: Implications for the enhanced pro-apoptotic activity of the G41S mutant Biochemical Journal, Oct 2013 DOI: 10.1042/BJ20130758
Journal Paper I03-Macromolecular Crystallography
Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis Journal Of Medicinal Chemistry, 56 (21) Oct 2013 DOI: 10.1021/jm4012033
Journal Paper I03-Macromolecular Crystallography
Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency Plos Pathogens, 9 Oct 2013 DOI: 10.1371/journal.ppat.1003673
Structure of an early native-like intermediate of β2-microglobulin amyloidogenesis Protein Science, 22 (10) Oct 2013 DOI: 10.1002/pro.2321
Journal Paper I03-Macromolecular Crystallography
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Elife, 2 Oct 2013 DOI: 10.7554/eLife.01340
Intramolecular isopeptide but not internal thioester bonds confer proteolytic and significant thermal stability to the S. pyogenes pilus adhesin Spy0125 Proteins: Structure, Function And Bioinformatics, Oct 2013 DOI: 10.1002/prot.24420
Sugar-coated sensor chip and nanoparticle surfaces for the in vitro enzymatic synthesis of starch-like materials Chemical Science, 5 (1) Oct 2013 DOI: 10.1039/c3sc51829a
Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP Acta Crystallographica Section D Biological Crystallography, 69 Sept 2013 DOI: 10.1107/S0907444913012687
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly Elife, 2 Sept 2013 DOI: 10.7554/eLife.01071
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
On the catalytic mechanism of dimeric dUTPases Biochemical Journal, Sept 2013 DOI: 10.1042/BJ20130796
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structural insights into proteoglycan-shaped Hedgehog signaling Proceedings Of The National Academy Of Sciences, Sept 2013 DOI: 10.1073/pnas.1310097110
Journal Paper I03-Macromolecular Crystallography
Structure of the NheA component of the Nhe toxin from Bacillus cereus: implications for function Plos One, 8 (9) Sept 2013 DOI: 10.1371/journal.pone.0074748
A two-domain elevator mechanism for sodium/proton antiport Nature, Sept 2013 DOI: 10.1038/nature12484
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1 Nature Structural & Molecular Biology, Sept 2013 DOI: 10.1038/nsmb.2668
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket Journal Of Biological Chemistry, 288 (39) Sept 2013 DOI: 10.1074/jbc.M113.474114
Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity Acta Crystallographica Section D Biological Crystallography, 69 Aug 2013 DOI: 10.1107/S0907444913015126
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport Nucleic Acids Research, Aug 2013 DOI: 10.1093/nar/gkt749
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structures of an Apo and a binary complex of an evolved archeal B family DNA polymerase capable of synthesising highly Cy-Dye labelled DNA Plos One, 8 (8) Aug 2013 DOI: 10.1371/journal.pone.0070892
Optimization of bimorph mirrors on x-ray synchrotron beamlines SPIE Newsroom, Aug 2013 DOI: 10.1117/2.1201308.005021
Magazine Article B16-Test Beamline I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I19-Small Molecule Single Crystal Diffraction I22-Small angle scattering & Diffraction I24-Microfocus Macromolecular Crystallography
Structural rearrangement in an RsmA/CsrA ortholog of Pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN Structure, Aug 2013 DOI: 10.1016/j.str.2013.07.007
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities Nature Communications, 4 Aug 2013 DOI: 10.1038/ncomms3164
Crystallization and preliminary X-ray characterization of the tetrapyrrole-biosynthetic enzyme porphobilinogen deaminase from Bacillus megaterium Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Aug 2013 DOI: 10.1107/S1744309113018526
Tying down the arm in Bacillus dUTPase: structure and mechanism Acta Crystallographica Section D Biological Crystallography, 69 Aug 2013 DOI: 10.1107/S090744491300735X
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Insights into Aurora-A kinase activation using unnatural amino acids incorporated by chemical modification Acs Chemical Biology, Aug 2013 DOI: 10.1021/cb400425t
Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism Journal Of Medicinal Chemistry, 56 (16) Jul 2013 DOI: 10.1021/jm4006274
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery Proceedings Of The National Academy Of Sciences, 110 (32) Jul 2013 DOI: 10.1073/pnas.1304045110
Journal Paper I03-Macromolecular Crystallography
Visualization of membrane protein crystals in lipid cubic phase using X-ray imaging Acta Crystallographica Section D Biological Crystallography, 69 Jul 2013 DOI: 10.1107/S0907444913011359
Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography Acta Crystallographica Section D Biological Crystallography, 69 Jul 2013 DOI: 10.1107/S0907444913012274
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis of Vps33A recruitment to the human HOPS complex by Vps16 Proceedings Of The National Academy Of Sciences, Jul 2013 DOI: 10.1073/pnas.1307074110
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Squeezing the most from every crystal: the fine details of data collection Acta Crystallographica Section D Biological Crystallography, 69 Jul 2013 DOI: 10.1107/S0907444913013280
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment Bmc Structural Biology, 13 Jul 2013 DOI: 10.1186/1472-6807-13-13
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis Cell, 154 (1) Jul 2013 DOI: 10.1016/j.cell.2013.05.046
α-L-fucosidase inhibition by pyrrolidine–ferrocene hybrids: rationalization of ligand-binding properties by structural studies Chemistry - A European Journal, 19 (29) Jul 2013 DOI: 10.1002/chem.201301001
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
The architecture of Trypanosoma brucei tubulin-binding cofactor B and implications for function Febs Journal, 280 (14) Jul 2013 DOI: 10.1111/febs.12308
Key mutations alter the cytochrome P450 BM3 conformational landscape and remove inherent substrate bias Journal Of Biological Chemistry, 288 (35) Jul 2013 DOI: 10.1074/jbc.M113.479717
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase Chembiochem, 14 (10) Jul 2013 DOI: 10.1002/cbic.201300307
Structure and activity of NADPH-dependent reductase Q1EQE0 from Streptomyces kanamyceticus, which catalyses the R-selective reduction of an imine substrate Chembiochem, 14 (11) Jul 2013 DOI: 10.1002/cbic.201300321
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Determination of potential scaffolds for human choline kinase α1 by chemical deconvolution studies Chembiochem, 14 (11) Jul 2013 DOI: 10.1002/cbic.201300195
Journal Paper I03-Macromolecular Crystallography
The BAH domain of Rsc2 is a histone H3 binding domain Nucleic Acids Research, Jul 2013 DOI: 10.1093/nar/gkt662
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure of the repulsive guidance molecule (RGM)–neogenin signaling hub Science, 341 (6141) Jul 2013 DOI: 10.1126/science.1232322
Journal Paper I03-Macromolecular Crystallography
The structure of Escherichia coli ExoIX--implications for DNA binding and catalysis in flap endonucleases Nucleic Acids Research, June 2013 DOI: 10.1093/nar/gkt591
Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations Structure, June 2013 DOI: 10.1016/j.str.2013.05.001
Structural basis of Brr2-Prp8 interactions and implications for U5 snRNP biogenesis and the spliceosome active site Structure, 21 (6) June 2013 DOI: 10.1016/j.str.2013.04.017
Picornavirus uncoating intermediate captured in atomic detail Nature Communications, 4 June 2013 DOI: 10.1038/ncomms2889
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human Immunoglobulin E Journal Of Biological Chemistry, June 2013 DOI: 10.1074/jbc.M113.480657
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein Genes & Development, 27 (11) June 2013 DOI: 10.1101/gad.212381.112
ErpC, a member of the complement regulator-acquiring family of surface proteins from Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 June 2013 DOI: 10.1107/S1744309113013249
Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases Journal Of Molecular Biology, June 2013 DOI: 10.1016/j.jmb.2013.06.015
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structures of Down Syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition Structure, 21 (6) June 2013 DOI: 10.1016/j.str.2013.03.012
Three dimensional structure of a bacterial α-l-fucosidase with a 5-membered iminocyclitol inhibitor Bioorganic & Medicinal Chemistry, 21 (16) June 2013 DOI: 10.1016/j.bmc.2013.05.056
Journal Paper I03-Macromolecular Crystallography
Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression Journal Of Biological Chemistry, 288 (23) June 2013 DOI: 10.1074/jbc.M112.420521
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Different photochemical events of a genetically encoded phenyl azide define and modulate GFP fluorescence Angewandte Chemie International Edition, 52 (23) June 2013 DOI: 10.1002/anie.201301490
Journal Paper I03-Macromolecular Crystallography
The application of the fragment-based screening approach to RmlA protein and PA1645 structure June 2013
Thesis I03-Macromolecular Crystallography
Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from Plasmodium falciparum Journal Of Medicinal Chemistry, 56 (12) June 2013 DOI: 10.1021/jm4005972
Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase The Journal Of Lipid Research, 54 (6) June 2013 DOI: 10.1194/jlr.M035410
Kinetic and mechanistic characterisation of Choline Kinase-α Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, 1834 June 2013 DOI: 10.1016/j.bbapap.2013.02.008
A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid Plos Pathogens, 9 (5) May 2013 DOI: 10.1371/journal.ppat.1003376
Correlating efficacy and desensitization with GluK2 ligand-binding domain movements Open Biology, 3 May 2013 DOI: 10.1098/rsob.130051
“Snapshots” of Ispinesib-induced conformational changes in the mitotic kinesin Eg5 Journal Of Biological Chemistry, May 2013 DOI: 10.1074/jbc.M113.462648
T-cell receptor specificity maintained by altered thermodynamics Journal Of Biological Chemistry, May 2013 DOI: 10.1074/jbc.M113.464560
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution Structure, Apr 2013 DOI: 10.1016/j.str.2013.03.008
Structural basis of kynurenine 3-monooxygenase inhibition Nature, Apr 2013 DOI: 10.1038/nature12039
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Ligand binding and aggregation of pathogenic SOD1 Nature Communications, 4 Apr 2013 DOI: 10.1038/ncomms2750
Bacteriophage P23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage Structure, Apr 2013 DOI: 10.1016/j.str.2013.02.026
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Marine Rhodobacteraceae l-haloacid dehalogenase contains a novel His/Glu dyad that could activate the catalytic water Febs Journal, 280 (7) Apr 2013 DOI: 10.1111/febs.12177
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural studies of Pseudomonas and Chromobacterium ω-aminotransferases provide insights into their differing substrate specificity Acta Crystallographica Section D Biological Crystallography, 69 Apr 2013 DOI: 10.1107/S0907444912051670
Liesegang-like patterns of Toll crystals grown in gel Journal Of Applied Crystallography, 46 Apr 2013 DOI: 10.1107/S0021889812051606
Structural basis for inhibition of the fat mass and obesity associated protein (FTO) Journal Of Medicinal Chemistry, 56 (9) Apr 2013 DOI: 10.1021/jm400193d
Journal Paper I03-Macromolecular Crystallography
Receptor binding by a ferret-transmissible H5 avian influenza virus Nature, 497 (7449) Apr 2013 DOI: 10.1038/nature12144
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
A new class of small molecule inhibitor of BMP signaling Plos One, 8 (4) Apr 2013 DOI: 10.1371/journal.pone.0062721
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system Nature Chemical Biology, 9 Apr 2013 DOI: 10.1038/nchembio.1212
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes Biochemical Journal, 451 Apr 2013 DOI: 10.1042/BJ20121871
Journal Paper I03-Macromolecular Crystallography
Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum Acta Crystallographica Section D Biological Crystallography, 69 Mar 2013 DOI: 10.1107/S0907444912049001
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Crystal structures of the catalytic domain of human soluble guanylate cyclase Plos One, 8 (3) Mar 2013 DOI: 10.1371/journal.pone.0057644
Interactions of a periplasmic binding protein with a tetradentate siderophore mimic Angewandte Chemie International Edition, Mar 2013 DOI: 10.1002/anie.201300751
M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation Proceedings Of The National Academy Of Sciences, Mar 2013 DOI: 10.1073/pnas.1217157110
The copper active site of CBM33 polysaccharide oxygenases Journal Of The American Chemical Society, 135 (16) Mar 2013 DOI: 10.1021/ja402106e
Journal Paper B18-Core EXAFS I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
The mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitor Angewandte Chemie International Edition, 52 (17) Feb 2013 DOI: 10.1002/anie.201209660
Journal Paper I03-Macromolecular Crystallography
Biochemical and immunological characterisation of Toxoplasma gondii macrophage migration inhibitory factor Journal Of Biological Chemistry, Feb 2013 DOI: 10.1074/jbc.M112.419911
Use of a molecular decoy to segregate transport from antigenicity in the FrpB iron transporter from Neisseria meningitidis Plos One, 8 (2) Feb 2013 DOI: 10.1371/journal.pone.0056746
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of Prp8 reveals active site cavity of the spliceosome Nature, Jan 2013 DOI: 10.1038/nature11843
Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases Journal Of Biological Chemistry, Jan 2013 DOI: 10.1074/jbc.M112.437996
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Jan 2013 DOI: 10.1107/S1744309112044739
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structural insights into a unique inhibitor binding pocket in kinesin spindle protein Journal Of The American Chemical Society, 135 (6) Jan 2013 DOI: 10.1021/ja310377d
Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, x-ray crystal structure, SAR and anti-cancer activities Journal Of Medicinal Chemistry, 56 (3) Jan 2013 DOI: 10.1021/jm301475f
Biocatalytic asymmetric alkene reduction: crystal structure and characterization of a double bond reductase from Nicotiana tabacum Acs Catalysis, 3 (3) Jan 2013 DOI: 10.1021/cs300709m
Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity Proceedings Of The National Academy Of Sciences, 110 (5) Jan 2013 DOI: 10.1073/pnas.1214943110
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Expression, purification and crystallization of the ectodomain of the envelope glycoprotein E2 from Bovine viral diarrhoea virus Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Jan 2013 DOI: 10.1107/S1744309112049184
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment Biochemical Journal, 449 Jan 2013 DOI: 10.1042/BJ20121209
Structural basis for duplex RNA recognition and cleavage by Archaeoglobus fulgidus C3PO Nature Structural & Molecular Biology, Jan 2013 DOI: 10.1038/nsmb.2487
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor Angewandte Chemie International Edition, Jan 2013 DOI: 10.1002/anie.201208046
Journal Paper I03-Macromolecular Crystallography
Novel inverse binding mode of indirubin derivatives yields improved selectivity for DYRK kinases Acs Medicinal Chemistry Letters, 4 (1) Jan 2013 DOI: 10.1021/ml300207a
X-ray crystallography and computational docking for the detection and development of protein-ligand interactions Current Medicinal Chemistry, 20 Jan 2013 DOI: 10.2174/0929867311320040008
- Balvinder Dhaliwal, Marie O. Y. Pang, Daopeng Yuan, Norhakim Yahya, Stella Fabiane, James M. Mcdonnell, Hannah J. Gould, Andrew J. Beavil, Brian J. Sutton, "Conformational plasticity at the IgE-binding site of the B-cell receptor CD23", Molecular Immunology, 56 (4), 693 - 697 (2013), DOI: 10.1016/j.molimm.2013.07.005
- [Thesis] Matthew Mold, "Complementary studies of the role of metals in the conformation and interactions of serum amyloid P component and β-amyloid Aβ42" (2013)
- Bing Xiao, Matthew J. Sanders, David Carmena, Nicola J. Bright, Lesley F. Haire, Elizabeth Underwood, Bhakti R. Patel, Richard B. Heath, Phillip A. Walker, Stefan Hallen, Fabrizio Giordanetto, Stephen R. Martin, David Carling, Steven Gamblin, "Structural basis of AMPK regulation by small molecule activators", Nature Communications, 4 (2013), DOI: 10.1038/ncomms4017
- Vadim Rimsa, Tom C. Eadsforth, William N. Hunter, "Two high-resolution structures of the human E3 ubiquitin ligase Siah1", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69, 1339 - 1343 (2013), DOI: 10.1107/S1744309113031448
- David Schwefel, Harriet C. T. Groom, Virginie C. Boucherit, Evangelos Christodoulou, Philip A. Walker, Jonathan P. Stoye, Kate N. Bishop, Ian A. Taylor, "Structural basis of lentiviral subversion of a cellular protein degradation pathway", Nature, 505 (7482), 234 - 238 (2013), DOI: 10.1038/nature12815
- Velupillai Srikannathasan, Grant English, Nhat Khai Bui, Katharina Trunk, Patrick E. F. O'Rourke, Vincenzo A. Rao, Waldemar Vollmer, Sarah J. Coulthurst, William N. Hunter, "Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens", Acta Crystallographica Section D Biological Crystallography, 69, 2468 - 2482 (2013), DOI: 10.1107/S0907444913022725
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