Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I03 Contact
Beamline Phone Number:
+44 (0) 1235 778707
Acting Principal Beamline Scientist:
Dave Hall
Tel: +44 (0) 1235 778926
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I03 MX
Status: Operational
Beamsize: 90 µm x 20 µm
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
Detector: Eiger2 XE 16M
Wavelength: 0.50 - 2.07 Å
Energy: 6 - 25 keV
These publications are based on data gathered on beamline I03. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
113 items found for 2014 [total: 2353]
Structure and function of a decarboxylating Agrobacterium tumefaciens keto-deoxy-d-galactarate dehydratase Biochemistry, 53 (51) Dec 2014 DOI: 10.1021/bi501290k
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions Structure, 22 (12) Dec 2014 DOI: 10.1016/j.str.2014.10.007
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Detection of tumor-associated glycopeptides by lectins: the peptide context modulates carbohydrate recognition Acs Chemical Biology, 10 (3) Dec 2014 DOI: 10.1021/cb500855x
Journal Paper I03-Macromolecular Crystallography
Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator Febs Letters, 588 (24) Dec 2014 DOI: 10.1016/j.febslet.2014.11.002
CetZ tubulin-like proteins control archaeal cell shape Nature, Dec 2014 DOI: 10.1038/nature13983
Journal Paper I03-Macromolecular Crystallography
The structural biology of patellamide biosynthesis Current Opinion In Structural Biology, 29 Dec 2014 DOI: 10.1016/j.sbi.2014.10.006
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
The crystal structure of the RhoA-Lbc DH-PH domain complex Biochemical Journal, 464 Dec 2014 DOI: 10.1042/BJ20140606
Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor Elife, 3 Dec 2014 DOI: 10.7554/eLife.05553
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Solving the structural difficulties of C. difficile Dec 2014
Science Highlight I02-Macromolecular Crystallography I03-Macromolecular Crystallography
Towards engineering hormone-binding globulins as drug delivery agents Plos One, 9 (11) Nov 2014 DOI: 10.1371/journal.pone.0113402
A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis Bioscience Reports, 34 Nov 2014 DOI: 10.1042/BSR20140143
Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers Nature Communications, 5 Nov 2014 DOI: 10.1038/ncomms6491
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis Nature Communications, 5 Nov 2014 DOI: 10.1038/ncomms6209
Closing the cohesin ring: Structure and function of its Smc3-kleisin interface Science, 346 (6212) Nov 2014 DOI: 10.1126/science.1256917
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Coevolution of the ATPase ClpV, the sheath proteins TssB and TssC, and the accessory protein TagJ/HsiE1 distinguishes type VI secretion classes Journal Of Biological Chemistry, 289 (47) Nov 2014 DOI: 10.1074/jbc.M114.600510
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg2+ channel MgtE Nature Communications, 5 Nov 2014 DOI: 10.1038/ncomms6374
Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights The Journal Of General Physiology, 144 (6) Nov 2014 DOI: 10.1085/jgp.201411219
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation Journal Of Biological Chemistry, Nov 2014 DOI: 10.1074/jbc.M114.604397
1,3-dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain Acs Medicinal Chemistry Letters, 5 (11) Nov 2014 DOI: 10.1021/ml5002932
Crystal structure of the Bacillus subtilis phosphodiesterase PhoD reveals an iron and calcium-containing active site Journal Of Biological Chemistry, 289 (45) Nov 2014 DOI: 10.1074/jbc.M114.604892
Targeting cancer cell metabolism as a therapeutic strategy Nov 2014
Thesis I03-Macromolecular Crystallography
Structural analysis of glucuronoxylan-specific Xyn30D and its attached CBM35 domain gives insights into the role of modularity in specificity Journal Of Biological Chemistry, 289 (45) Nov 2014 DOI: 10.1074/jbc.M114.597732
Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus Journal Of Biological Chemistry, 289 (48) Nov 2014 DOI: 10.1074/jbc.M114.608448
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Untangling the mysteries of curli fibres Nov 2014
Science Highlight I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A complex gene locus enables xyloglucan utilization in the model saprophyte Molecular Microbiology, 94 (2) Oct 2014 DOI: 10.1111/mmi.12776
A sialic acid binding site in a human picornavirus Plos Pathogens, 10 (10) Oct 2014 DOI: 10.1371/journal.ppat.1004401
A critical base pair in k-turns that confers folding characteristics and correlates with biological function Nature Communications, 5 Oct 2014 DOI: 10.1038/ncomms6127
FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development Neuron, 84 (2) Oct 2014 DOI: 10.1016/j.neuron.2014.10.008
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure-guided design and optimization of small molecules targeting the protein–protein interaction between the von Hippel–Lindau (VHL) E3 ubiquitin ligase and the Hypoxia Inducible Factor (HIF) alpha subunit with in vitro nanomolar affinities Journal Of Medicinal Chemistry, 57 (20) Oct 2014 DOI: 10.1021/jm5011258
Hepatitis A virus and the origins of picornaviruses Nature, 517 (7532) Oct 2014 DOI: 10.1038/nature13806
Structure-based design of potent and selective leishmaniaN-myristoyltransferase inhibitors Journal Of Medicinal Chemistry, 57 (20) Oct 2014 DOI: 10.1021/jm5011397
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The structure of a tetrameric alpha-carbonic anhydrase from Thermovibrio ammonificans reveals a core formed around intermolecular disulfides that contribute to its thermostability Acta Crystallographica Section D Biological Crystallography, 70 Oct 2014 DOI: 10.1107/S1399004714016526
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Computational design of water-soluble alpha-helical barrels Science, 346 (6208) Oct 2014 DOI: 10.1126/science.1257452
Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal DUF490 (963-1138) domain of TamB from Escherichia coli Acta Crystallographica Section F Structural Biology Communications, 70 Sept 2014 DOI: 10.1107/S2053230X14017403
Journal Paper I03-Macromolecular Crystallography
Structure and interactions of the Bacillus subtilis sporulation inhibitor of DNA replication, SirA, with domain I of DnaA Molecular Microbiology, 93 (5) Sept 2014 DOI: 10.1111/mmi.12713
Journal Paper I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of the 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP Acta Crystallographica Section D Biological Crystallography, 70 Sept 2014 DOI: 10.1107/S1399004714015053
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites Organic & Biomolecular Chemistry, 12 (41) Sept 2014 DOI: 10.1039/C4OB01669F
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor Medchemcomm, 5 (12) Sept 2014 DOI: 10.1039/C4MD00291A
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Crystal structures of Ophiostoma piceae sterol esterase: Structural insights into activation mechanism and product release Journal Of Structural Biology, 187 (3) Sept 2014 DOI: 10.1016/j.jsb.2014.07.007
Journal Paper I03-Macromolecular Crystallography
Structure of the pneumococcal l,d-carboxypeptidase DacB and pathophysiological effects of disabled cell wall hydrolases DacA and DacB Molecular Microbiology, Sept 2014 DOI: 10.1111/mmi.12729
Journal Paper I03-Macromolecular Crystallography
Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG Nature, Sept 2014 DOI: 10.1038/nature13768
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A complex iron-calcium cofactor catalyzing phosphotransfer chemistry Science, 345 Sept 2014 DOI: 10.1126/science.1254237
Journal Paper I03-Macromolecular Crystallography
A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics Nature Chemical Biology, 10 (10) Sept 2014 DOI: 10.1038/nchembio.1629
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Tracing the evolution of the p53 tetramerization domain Structure, 22 (9) Sept 2014 DOI: 10.1016/j.str.2014.07.010
The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids Journal Of Structural Biology, 187 (3) Sept 2014 DOI: 10.1016/j.jsb.2014.07.004
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation Proceedings Of The National Academy Of Sciences, 111 (37) Sept 2014 DOI: 10.1073/pnas.1409916111
Structures of pyruvate kinases display evolutionarily divergent allosteric strategies Royal Society Open Science, 1 Sept 2014 DOI: 10.1098/rsos.140120
The structure of a PII signaling protein from a halophilic archaeon reveals novel traits and high-salt adaptations Febs Journal, 281 (15) Aug 2014 DOI: 10.1111/febs.12881
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 Journal Of Medicinal Chemistry, 57 (15) Aug 2014 DOI: 10.1021/jm500483b
Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC) Acta Crystallographica Section D Biological Crystallography, 70 Aug 2014 DOI: 10.1107/S1399004714013455
Molecular mechanism of ligand recognition by membrane transport protein, Mhp1 The Embo Journal, 33 (16) Aug 2014 DOI: 10.15252/embj.201387557
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein Acta Crystallographica Section D Biological Crystallography, 70 Aug 2014 DOI: 10.1107/S139900471401267X
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells Nature Communications, 5 Aug 2014 DOI: 10.1038/ncomms5919
AP2 controls clathrin polymerization with a membrane-activated switch Science, 345 (6195) Jul 2014 DOI: 10.1126/science.1254836
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structural basis of chitin oligosaccharide deacetylation Angewandte Chemie International Edition, 53 (27) Jul 2014 DOI: 10.1002/anie.201400220
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2 Nature Structural & Molecular Biology, 21 (8) Jul 2014 DOI: 10.1038/nsmb.2860
Journal Paper I03-Macromolecular Crystallography
Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation The Embo Journal, 33 (14) Jul 2014 DOI: 10.15252/embj.201488373
The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Acta Crystallographica Section D Biological Crystallography, 70 Jul 2014 DOI: 10.1107/S1399004714009997
Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake Molecular Microbiology, 93 (2) Jul 2014 DOI: 10.1111/mmi.12655
Structures of bacterial kynurenine formamidase reveal a crowded binuclear-zinc catalytic site primed to generate a potent nucleophile. Biochemical Journal, 462 June 2014 DOI: 10.1042/BJ20140511
Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted Type II kinase inhibitors Journal Of Molecular Biology, 426 (13) June 2014 DOI: 10.1016/j.jmb.2014.04.014
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
A molecular model for the role of SYCP3 in meiotic chromosome organisation Elife, 3 June 2014 DOI: 10.7554/eLife.02963
VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface Developmental Cell, 29 (5) June 2014 DOI: 10.1016/j.devcel.2014.04.010
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Human UTY(KDM6C) is a male-specific nϵ-methyl lysyl demethylase Journal Of Biological Chemistry, 289 (26) June 2014 DOI: 10.1074/jbc.M114.555052
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1 Structure, 22 (6) June 2014 DOI: 10.1016/j.str.2014.04.001
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Identification of NAD(P)H quinone oxidoreductase activity in azoreductases from p. aeruginosa: azoreductases and NAD(P)H quinone oxidoreductases belong to the same FMN-dependent superfamily of enzymes Plos One, 9 (6) June 2014 DOI: 10.1371/journal.pone.0098551
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism Proceedings Of The National Academy Of Sciences, 111 (23) June 2014 DOI: 10.1073/pnas.1406855111
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Random single amino acid deletion sampling unveils structural tolerance and the benefits of helical registry shift on GFP folding and structure Structure, 22 (6) June 2014 DOI: 10.1016/j.str.2014.03.014
Structural basis for outer membrane lipopolysaccharide insertion Nature, 511 (7507) June 2014 DOI: 10.1038/nature13464
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
In vitro resistance selections for plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth Journal Of Biological Chemistry, 289 (26) June 2014 DOI: 10.1074/jbc.M114.558353
Discovery of (10R)-7-smino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) Journal Of Medicinal Chemistry, 57 (11) June 2014 DOI: 10.1021/jm500261q
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Crystal structure of CyanoQ from the thermophilic cyanobacterium Thermosynechococcus elongatus and detection in isolated photosystem II complexes Photosynthesis Research, 122 (1) May 2014 DOI: 10.1007/s11120-014-0010-z
Enhanced human receptor binding by H5 haemagglutinins Virology, 456 May 2014 DOI: 10.1016/j.virol.2014.03.008
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling Molecular Cell, 54 (3) May 2014 DOI: 10.1016/j.molcel.2014.03.016
Journal Paper I03-Macromolecular Crystallography
Bacterial actin MreB forms antiparallel double filaments Elife, 3 May 2014 DOI: 10.7554/eLife.02634
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
A Ctf4 trimer couples the CMG helicase to DNA polymerase alpha in the eukaryotic replisome Nature, 510 (7504) May 2014 DOI: 10.1038/nature13234
Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae Elife, 3 May 2014 DOI: 10.7554/eLife.02674
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Biochemical and structural characterisation of a haloalkane dehalogenase from a marine Rhodobacteraceae Febs Letters, 588 (9) May 2014 DOI: 10.1016/j.febslet.2014.02.056
Structural insights into higher order assembly and function of the bacterial microcompartment protein PduA Journal Of Biological Chemistry, 289 (32) May 2014 DOI: 10.1074/jbc.M114.569285
Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA Acta Crystallographica Section D Biological Crystallography, 70 May 2014 DOI: 10.1107/S139900471400501X
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases Structure, 22 (5) May 2014 DOI: 10.1016/j.str.2014.01.013
Journal Paper I03-Macromolecular Crystallography
Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands Proceedings Of The National Academy Of Sciences, 111 (20) May 2014 DOI: 10.1073/pnas.1319683111
Ribosomal oxygenases are structurally conserved from prokaryotes to humans Nature, 509 (7505) May 2014 DOI: 10.1038/nature13263
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Hemolytic lectin CEL-III heptamerizes via a large structural transition from α-helices to a β-barrel during the transmembrane pore formation process Journal Of Biological Chemistry, 289 (18) May 2014 DOI: 10.1074/jbc.M113.541896
Analysis of an industrial production suspension of Bacillus lentus subtilisin crystals by powder diffraction: a powerful quality-control tool Acta Crystallographica Section D Biological Crystallography, 70 Apr 2014 DOI: 10.1107/S1399004714001497
Enzymatic and structural characterization of rTSγ provides insights into the function of rTSβ Biochemistry, 53 (16) Apr 2014 DOI: 10.1021/bi500349e
Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical β-propeller domain Proceedings Of The National Academy Of Sciences, 111 (14) Apr 2014 DOI: 10.1073/pnas.1322892111
Journal Paper I03-Macromolecular Crystallography
Binding mode and structure–activity relationships around direct inhibitors of the Nrf2–Keap1 complex Chemmedchem, 9 (4) Apr 2014 DOI: 10.1002/cmdc.201300525
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Niche bacteria with a profound effect on your diet Apr 2014
Science Highlight I03-Macromolecular Crystallography
A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR Biochemical Journal, 458 Mar 2014 DOI: 10.1042/BJ20131127
Structural evidence for the partially oxidized dipyrromethene and dipyrromethanone forms of the cofactor of porphobilinogen deaminase: structures of the Acta Crystallographica Section D Biological Crystallography, 70 Mar 2014 DOI: 10.1107/S139900471303294X
Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1 Nature, 507 (7490) Mar 2014 DOI: 10.1038/nature13116
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB) Peerj, 2 Mar 2014 DOI: 10.7717/peerj.305
Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1 Open Biology, 4 (3) Mar 2014 DOI: 10.1098/rsob.130172
Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01 The Journal Of Immunology, 192 (7) Mar 2014 DOI: 10.4049/jimmunol.1302667
Human immunoglobulin E flexes between acutely bent and extended conformations Nature Structural & Molecular Biology, 21 (4) Mar 2014 DOI: 10.1038/nsmb.2795
Journal Paper I03-Macromolecular Crystallography
Structure and activity of the Streptomyces coelicolor A3(2) β-N-acetylhexosaminidase provides further insight into GH20 family catalysis and inhibition Biochemistry, 53 (11) Mar 2014 DOI: 10.1021/bi401697j
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Pyruvate kinases have an intrinsic and conserved decarboxylase activity Biochemical Journal, 458 (2) Mar 2014 DOI: 10.1042/BJ20130790
Structural basis for nuclear import of splicing factors by human Transportin 3 Proceedings Of The National Academy Of Sciences, 111 (7) Feb 2014 DOI: 10.1073/pnas.1320755111
GpIbα interacts exclusively with exosite II of thrombin Journal Of Molecular Biology, 426 (4) Feb 2014 DOI: 10.1016/j.jmb.2013.11.027
Interkingdom pharmacology of angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes Acs Medicinal Chemistry Letters, 5 (4) Feb 2014 DOI: 10.1021/ml4004588
More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules Nature Structural & Molecular Biology, 21 (3) Feb 2014 DOI: 10.1038/nsmb.2769
High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase in complex with magnesium ions Plos One, 9 (2) Feb 2014 DOI: 10.1371/journal.pone.0087577
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors Biochemical Journal, 457 Feb 2014 DOI: 10.1042/BJ20131272
Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives Journal Of Medicinal Chemistry, 57 (2) Jan 2014 DOI: 10.1021/jm401665x
Structure of the SAS-6 cartwheel hub from Leishmania major Elife, 3 Jan 2014 DOI: 10.7554/eLife.01812
A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes Nature, Jan 2014 DOI: 10.1038/nature12907
Journal Paper I03-Macromolecular Crystallography
Structures of adenosine kinase from Trypanosoma brucei brucei Acta Crystallographica Section F Structural Biology Communications, 70 Jan 2014 DOI: 10.1107/S2053230X13033621
How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase Biochemical Journal, Jan 2014 DOI: 10.1042/BJ20131520
Structure and self-assembly of the calcium binding matrix protein of human metapneumovirus Structure, 22 (1) Jan 2014 DOI: 10.1016/j.str.2013.10.013
Journal Paper I03-Macromolecular Crystallography I22-Small angle scattering & Diffraction open access
Combined inhibitor free-energy landscape and structural analysis reports on the mannosidase conformational coordinate Angewandte Chemie International Edition, 53 (4) Jan 2014 DOI: 10.1002/anie.201308334
Structural and functional characterisation of human carboxylesterases Jan 2014
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography
- Helena Taberman, Martina Andberg, Tarja Parkkinen, Janne Jänis, Merja Penttilä, Nina Hakulinen, Anu Koivula, Juha Rouvinen, "Structure and function of a decarboxylating Agrobacterium tumefaciens keto-deoxy-d-galactarate dehydratase", Biochemistry, 53 (51) (2014), DOI: 10.1021/bi501290k
- Tom D. Bunney, Ambrose R. Cole, Malgorzata Broncel, Diego Esposito, Edward W. Tate, Matilda Katan, "Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions", Structure, 22 (12), 1831 - 1843 (2014), DOI: 10.1016/j.str.2014.10.007
- David Madariaga, Nuria Martínez-Sáez, Víctor J. Somovilla, Helena Coelho, Jessika Valero-González, Jorge Castro-López, Juan L. Asensio, Jesús Jiménez-Barbero, Jesús H. Busto, Alberto Avenoza, Filipa Marcelo, Ramón Hurtado-Guerrero, Francisco Corzana, Jesús M. Peregrina, "Detection of tumor-associated glycopeptides by lectins: the peptide context modulates carbohydrate recognition", Acs Chemical Biology, 10 (3), 747 - 756 (2014), DOI: 10.1021/cb500855x
- Curtis Phippen, Halina Mikolajek, Henry Schlaefli, Charles William Keevil, Jeremy Stephen Webb, Ivo Tews, "Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator", Febs Letters, 588 (24), 4631 - 4636 (2014), DOI: 10.1016/j.febslet.2014.11.002
- Iain G. Duggin, Christopher Aylett, James C. Walsh, Kate Michie, Qing Wang, Lynne Turnbull, Emma M. Dawson, Elizabeth J. Harry, Cynthia B. Whitchurch, Linda A. Amos, Jan Lowe, "CetZ tubulin-like proteins control archaeal cell shape", Nature (2014), DOI: 10.1038/nature13983
- Jesko Koehnke, Andrew Bent, Wael E Houssen, Greg Mann, Marcel Jaspars, James Naismith, "The structural biology of patellamide biosynthesis", Current Opinion In Structural Biology, 29, 112 - 121 (2014), DOI: 10.1016/j.sbi.2014.10.006
- Kamalâ R. Abdul Azeez, Stefan Knapp, Joãoâ M. P. Fernandes, Enno Klussmann, Jonathan M. Elkins, "The crystal structure of the RhoA-Lbc DH-PH domain complex", Biochemical Journal, 464, 231 - 239 (2014), DOI: 10.1042/BJ20140606
- Harriet Lane-Serff, Paula Macgregor, Ed Lowe, Mark Carrington, Matthew K Higgins, "Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor", Elife, 3 (2014), DOI: 10.7554/eLife.05553
- [Science Highlight] Diamond Light Source, "Solving the structural difficulties of C. difficile" (2014)
- Wee Lee Chan, Aiwu Zhou, Randy J. Read, "Towards engineering hormone-binding globulins as drug delivery agents", Plos One, 9 (11) (2014), DOI: 10.1371/journal.pone.0113402
- Eva Ullmann, Tien-Chye Tan, Thomas Gundinger, Christoph Herwig, Christina Divne, Oliver Spadiut, "A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis", Bioscience Reports, 34, 893 - 904 (2014), DOI: 10.1042/BSR20140143
- Chancievan Thangaratnarajah, Jonathan Ruprecht, Edmund Kunji, "Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers", Nature Communications, 5 (2014), DOI: 10.1038/ncomms6491
- Charlotte H Coles, Nikolaos Mitakidis, Peng Zhang, Jonathan Elegheert, Weixian Lu, Andrew W. Stoker, Terunaga Nakagawa, Ann Marie Craig, E. Yvonne Jones, A. Radu Aricescu, "Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis", Nature Communications, 5 (2014), DOI: 10.1038/ncomms6209
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