Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
52 items found for 2026 [total: 2283]
Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships European Journal Of Medicinal Chemistry, 315 Oct 2026 DOI: 10.1016/j.ejmech.2026.118977
Journal Paper I04-Macromolecular Crystallography
Structural characterization of an S8 protease from Fervidobacterium pennivorans reveals a unique tyrosine-rich β-hairpin Enzyme And Microbial Technology, 199 Aug 2026 DOI: 10.1016/j.enzmictec.2026.110904
Rational design of small-molecule stabilizers of human fumarylacetoacetate hydrolase for the treatment of Tyrosinemia Type I Journal Of Medicinal Chemistry, 47 May 2026 DOI: 10.1021/acs.jmedchem.5c03489
Journal Paper I04-Macromolecular Crystallography
Fluorogenic coupled assays reveal catalytic properties, inhibition constants and cellular location of mucin-active carbohydrate sulfatases Angewandte Chemie International Edition, 597 May 2026 DOI: 10.1002/anie.2991471
Design of a site selective heterochromic bimetallic lanthanide coiled coil with nanometre-scale control Chemical Science, 140 May 2026 DOI: 10.1039/D6SC00813E
Crystal structure of HERV-K envelope glycoprotein surface subunit Journal Of Virology, May 2026 DOI: 10.1128/jvi.00195-26
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants Proceedings Of The National Academy Of Sciences, 123 May 2026 DOI: 10.1073/pnas.2531747123
Journal Paper I04-Macromolecular Crystallography
Identification of the piperidyl urea derivative BAY-439 as a potent and selective inhibitor of human phospholipase A2 Group V (hPLA2-G5) for the treatment of inflammatory pain Journal Of Medicinal Chemistry, May 2026 DOI: 10.1021/acs.jmedchem.6c00488
Journal Paper I04-Macromolecular Crystallography
Low-barrier hydrogen bond powers long-range radical transfer in the metal-free ribonucleotide reductase Proceedings Of The National Academy Of Sciences, 123 May 2026 DOI: 10.1073/pnas.2529856123
Ferritin iron mineralisation: route of Fe3+ Transfer from the ferroxidase centre to the inner cavity of human H-chain ferritin Angewandte Chemie International Edition, May 2026 DOI: 10.1002/anie.1203843
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Targeting a pleckstrin homology domain with a lysine-reactive covalent binder Journal Of Medicinal Chemistry, May 2026 DOI: 10.1021/acs.jmedchem.5c03818
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
A versatile nanobody platform for live and super-resolution imaging of synaptic vesicle dynamics and plasticity in rodent and human neurons Journal Of Nanobiotechnology, 24 May 2026 DOI: 10.1186/s12951-026-04489-w
Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells Nature, 44 Apr 2026 DOI: 10.1038/s41586-026-10394-x
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Automated molecular design in BRADSHAW, applied to the optimization of ERAP1 inhibitors Journal Of Medicinal Chemistry, Apr 2026 DOI: 10.1021/acs.jmedchem.5c03071
Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction Structure, 4 Apr 2026 DOI: 10.1016/j.str.2026.04.001
Using X-ray crystallography and 1,n-ADEQUATE NMR to revise the structures of highly substituted aromatic natural products: the absolute configuration of formicamycin congeners Journal Of Natural Products, Apr 2026 DOI: 10.1021/acs.jnatprod.6c00145
Covalent targeting of histidine residues: a ligand-first approach Journal Of Medicinal Chemistry, Apr 2026 DOI: 10.1021/acs.jmedchem.5c03255
Journal Paper I04-Macromolecular Crystallography
The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase Acta Crystallographica Section D Structural Biology, 82 Apr 2026 DOI: 10.1107/S2059798326001968
Optimized bacterial expression of a synthetic BRIL antibody Acta Crystallographica Section F Structural Biology Communications, 82 Apr 2026 DOI: 10.1107/S2053230X26001548
Crystallization and 1.6 Å resolution crystal structure of an acylated GLP-1/GIP analogue peptide Acta Crystallographica Section F Structural Biology Communications, 82 Apr 2026 DOI: 10.1107/S2053230X26001937
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Discovery and characterization of novel 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthase from thermophilic (meta)genomes Catalysts, 16 Apr 2026 DOI: 10.3390/catal16040305
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Targeting the interaction of NRF2 and β-TrCP with molecular glues Acs Chemical Biology, Mar 2026 DOI: 10.1021/acschembio.5c01006
Journal Paper I04-Macromolecular Crystallography
The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence Biochemical Journal, Mar 2026 DOI: 10.1042/BCJ20260019
De novo design of chromophore-binding peptide assemblies and single-chain proteins Mar 2026
Thesis B21-High Throughput SAXS I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural studies of βTrCP reveal plasticity in binding modes of consensus and nonconsensus degrons Acs Chemical Biology, Mar 2026 DOI: 10.1021/acschembio.5c01007
Hydroxamate-based inhibitors reveal structural determinants of selectivity for Plasmodium falciparum aminopeptidase P Journal Of Biological Chemistry, 387 Mar 2026 DOI: 10.1016/j.jbc.2026.111372
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Residue-level determination of small-molecule-protein affinities by hydrogen-deuterium exchange mass spectrometry Journal Of The American Society For Mass Spectrometry, Mar 2026 DOI: 10.1021/jasms.6c00020
Design and synthesis of BLU-654, a potent and selective mutant KIT V654A inhibitor for the treatment of imatinib-resistant GIST Journal Of Medicinal Chemistry, 22 Mar 2026 DOI: 10.1021/acs.jmedchem.5c03554
A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader Nature Communications, 38 Mar 2026 DOI: 10.1038/s41467-026-70663-1
Mechanism of interaction between the transactivation domain of N-myc and the DNA-binding surface of TFIIIC5 Nucleic Acids Research, 54 Mar 2026 DOI: 10.1093/nar/gkag181
Multicyclic D-stereospecific hydrolase dimer with high sustained activity Angewandte Chemie International Edition, 85 Mar 2026 DOI: 10.1002/anie.202521611
Journal Paper I04-Macromolecular Crystallography
BtuJ1, a surface-exposed B12-binding protein in Bacteroidota, functions as an extracellular vitamin reservoir that enhances fitness Journal Of Molecular Biology, 375 Mar 2026 DOI: 10.1016/j.jmb.2026.169754
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Metal-dependent 2-keto-3,6-dideoxy-6-sulfo-gluconate (KDSG) aldolase: decoding the key C-C bond cleaving step in bacterial sulfoglycolysis Chemistry – A European Journal, 28 Mar 2026 DOI: 10.1002/chem.70857
Position-5-driven reorientation of an immunodominant HLA-A*24:02 SARS-CoV-2 epitope drives universal T-cell escape Jci Insight, Mar 2026 DOI: 10.1172/jci.insight.202235
Synthesis and characterization of ULK1/2 kinase inhibitors that inhibit autophagy and upregulate expression of major histocompatibility complex I for the treatment of non-small cell lung cancer Acs Chemical Biology, Feb 2026 DOI: 10.1021/acschembio.5c00711
Journal Paper I04-Macromolecular Crystallography
Crystal structure of a tRNA acceptor-stem mimic at 1.94 Å resolution Acta Crystallographica Section F Structural Biology Communications, 82 Feb 2026 DOI: 10.1107/S2053230X26000658
Phosphorylation of inner core heptose is a major determinant of bacterial surface lipopolysaccharide recognition by the innate immune protein hSP-D Journal Of Biological Chemistry, 164 Feb 2026 DOI: 10.1016/j.jbc.2026.111307
Defining the mechanism of cross-reactivity for a SARS-CoV-2 Beta-elicited antibody toward omicron sub-lineages Structure, 22 Feb 2026 DOI: 10.1016/j.str.2026.01.006
Molecular basis of c-MET inhibition by approved small molecule drugs: a structural perspective Acs Medicinal Chemistry Letters, Feb 2026 DOI: 10.1021/acsmedchemlett.5c00713
Fragment-based development of NSP14 exonuclease inhibitors confounded by batch-to-batch variability Acs Chemical Biology, Feb 2026 DOI: 10.1021/acschembio.5c00930
Kinetic and structural characterisation of domain‐specific angiotensin I‐converting enzyme inhibition by captopril, rentiapril and zofenoprilat The Febs Journal, 29 Feb 2026 DOI: 10.1111/febs.70428
Discovery of spiro[chromane-2,4′-piperidine] derivatives as irreversible inhibitors of SARS-CoV-2 papain-like protease Journal Of Medicinal Chemistry, Feb 2026 DOI: 10.1021/acs.jmedchem.5c03704
Utilizing constrained bicyclic peptides for in vitro diagnostics Acs Nano, Feb 2026 DOI: 10.1021/acsnano.5c19041
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt Cell Death & Disease, 85 Feb 2026 DOI: 10.1038/s41419-026-08492-9
Structural basis for carbohydrate recognition by the Gal/GalNAc lectin of Entamoeba histolytica involved in host cell adhesion Plos Pathogens, 22 Feb 2026 DOI: 10.1371/journal.ppat.1013948
Electrochemical insight into the copper redox chemistry and H2O2 and O2 reducing capability of two AA10 lytic polysaccharide monooxygenases Acs Electrochemistry, 679 Jan 2026 DOI: 10.1021/acselectrochem.5c00266
Discovery of fragment-based inhibitors of SARS-CoV-2 PLPro Journal Of Medicinal Chemistry, Jan 2026 DOI: 10.1021/acs.jmedchem.5c02832
WRN structural flexibility showcased through fragment-based lead discovery of inhibitors Nature Communications, 17 Jan 2026 DOI: 10.1038/s41467-025-66768-8
Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase Rsc Medicinal Chemistry, 22 Jan 2026 DOI: 10.1039/D5MD00896D
Journal Paper I04-Macromolecular Crystallography
Cell wall target fragment discovery using a low‐cost, minimal fragment library Febs Letters, 12 Jan 2026 DOI: 10.1002/1873-3468.70281
Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery Proceedings Of The National Academy Of Sciences, 123 Jan 2026 DOI: 10.1073/pnas.2525941123
Multi-crystal X-ray diffraction (MCXRD) bridges the crystallographic characterisation gap in chemistry and materials science: application to MOFs Angewandte Chemie International Edition, 1 Jan 2026 DOI: 10.1002/anie.202523233
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography VMXm-Versatile Macromolecular Crystallography microfocus open access
- Stéphane Bourg, Matthieu Place, Chloé Copin, Apirat Chaikuad, Thomas Robert, Hanna Holzmann, Susanne Müller, Stéphane Bach, Sandrine Ruchaud, Stefan Knapp, Frédéric Buron, Sylvain Routier, Pascal Bonnet, "Identification of novel CLK1 inhibitors by computational fragment-based ligand design, co-crystallization, chemical synthesis and structure activity relationships", European Journal Of Medicinal Chemistry, 315 (2026), DOI: 10.1016/j.ejmech.2026.118977
- Michail W. Kruger, Gabriela C. Schröder, Rubén Javier-López, Carmien Tolmie, Ana C. Ebrecht, Jennifer A. Littlechild, Jean Armengaud, Nils-Kåre Birkeland, Diederik J. Opperman, "Structural characterization of an S8 protease from Fervidobacterium pennivorans reveals a unique tyrosine-rich β-hairpin", Enzyme And Microbial Technology, 199 (2026), DOI: 10.1016/j.enzmictec.2026.110904
- Riccardo Scarin, Adriana L. Rojas, Jon Gil-Martínez, Margarita Gómez-Galán, Ángel Torres-Mozas, Fernando Lopitz-Otsoa, David Fernández-Ramos, Gonzalo Jiménez-Osés, José M. Mato, Oscar Millet, "Rational design of small-molecule stabilizers of human fumarylacetoacetate hydrolase for the treatment of Tyrosinemia Type I", Journal Of Medicinal Chemistry, 47 (2026), DOI: 10.1021/acs.jmedchem.5c03489
- Charles W. E. Tomlinson, Madouc D. Bergers, David N. Bolam, Ana S. Luis, Alan Cartmell, Zachary Armstrong, "Fluorogenic coupled assays reveal catalytic properties, inhibition constants and cellular location of mucin-active carbohydrate sulfatases", Angewandte Chemie International Edition, 597 (2026), DOI: 10.1002/anie.2991471
- Louise N. Slope, Anokhi Shah, Michael J. Taylor, Valentina Borghesani, Simon G. Caulton, Nicholas J. Brooks, Kate A. Hadley, Georgina Rose, Robert I. Hunter, Hassane E. L. Mkami, Graham M. Smith, Aneika C. Leney, Niklaas J. Buurma, Andrew L. Lovering, Janet E. Lovett, Anna F. A. Peacock, "Design of a site selective heterochromic bimetallic lanthanide coiled coil with nanometre-scale control", Chemical Science, 140 (2026), DOI: 10.1039/D6SC00813E
- Nikos Nikolopoulos, Yorgo Modis, "Crystal structure of HERV-K envelope glycoprotein surface subunit", Journal Of Virology (2026), DOI: 10.1128/jvi.00195-26
- Philipp Münick, Dimitrios-Ilias Balourdas, Julianne S. Funk, Büşra Yüksel, Danai Mavridi, Justin Heftel, Birgit Dreier, Jonas V. Schaefer, Birgit Schäfer, Stefan Knapp, Tümay Telatar, Baki Akgül, Andreas Plückthun, Thorsten Stiewe, Andreas C. Joerger, Volker Dötsch, "DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants", Proceedings Of The National Academy Of Sciences, 123 (2026), DOI: 10.1073/pnas.2531747123
- Gernot Langer, Nico Bräuer, Daryl Walter, Stuart Flanagan, Olivier Rémi Barbeau, Wei Tsung Yau, James Jenkins, Dennis Wegener, Daren Fearon, Anne-Marie Coelho, Benjamin Bader, Anders Friberg, Hartmut Beck, Vera Pütter, Frank Sacher, "Identification of the piperidyl urea derivative BAY-439 as a potent and selective inhibitor of human phospholipase A2 Group V (hPLA2-G5) for the treatment of inflammatory pain", Journal Of Medicinal Chemistry (2026), DOI: 10.1021/acs.jmedchem.6c00488
- Abhishek Sirohiwal, Juliane John, Yury Kutin, Rohit Kumar, Federico Baserga, Vivek Srinivas, Hugo Lebrette, Maximilian C. Pöverlein, Ana P. Gamiz-Hernandez, Joachim Heberle, Müge Kasanmascheff, Martin Högbom, Ville R. I. Kaila, "Low-barrier hydrogen bond powers long-range radical transfer in the metal-free ribonucleotide reductase", Proceedings Of The National Academy Of Sciences, 123 (2026), DOI: 10.1073/pnas.2529856123
- Zinnia Bugg, Justin M. Bradley, Andrew M. Hemmings, Nick Le Brun, "Ferritin iron mineralisation: route of Fe3+ Transfer from the ferroxidase centre to the inner cavity of human H-chain ferritin", Angewandte Chemie International Edition (2026), DOI: 10.1002/anie.1203843
- Rebekah M. West, Radu Costin Bizga Nicolescu, Paul Brear, James Wagstaff, Beata K. Blaszczyk, Tomas Deingruber, Matthew G. Sanders, Francisco Javier Pérez-Areales, David R. Spring, Marko Hyvonen, "Targeting a pleckstrin homology domain with a lysine-reactive covalent binder", Journal Of Medicinal Chemistry (2026), DOI: 10.1021/acs.jmedchem.5c03818
- Rashi Goel, Kristina Jevdokimenko, Ronja Rehm, Jannik Hentze, Paola Agüi-Gonzalez, Momchil Ninov, Erik Maier, Yin Wu, Felix Lange, Agata Witkowska, Svenja Bolz, Francesca Pennacchietti, Martina Damenti, Natalie Kaempf, Vladimir Khayenko, Carles Calatayud, Viveka Nand Malviya, Natali L. Chanaday, Emma Scaletti Hutchinson, Hao Liu, Kirsten Weyand, Valentin Schwarze, Daniela Ivanova, Tristan P. Wallis, Christopher Small, Hans M. Maric, Merja Joensuu, Michael A. Cousin, Frédéric A. Meunier, Patrik Verstreken, Ilaria Testa, Ege T. Kavalali, Volker Haucke, Stefan Jakobs, Henning Urlaub, Nils Brose, Benjamin H. Cooper, Pal Stenmark, Felipe Opazo, Reinhard Jahn, Silvio O. Rizzoli, Eugenio F. Fornasiero, "A versatile nanobody platform for live and super-resolution imaging of synaptic vesicle dynamics and plasticity in rodent and human neurons", Journal Of Nanobiotechnology, 24 (2026), DOI: 10.1186/s12951-026-04489-w
- Giulia Gallo, Antonello Di Nardo, Doreen Lugano, Adam J. Roberts, Bernadette Ataku Kutima, Moses Okombo, Aghnianditya Kresno Dewantari, Florence M. M. Buckley, Gavin J. Wright, James Nyagwange, Bernard Agwanda, Stephen C. Graham, Dalan Bailey, "Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells", Nature, 44 (2026), DOI: 10.1038/s41586-026-10394-x
- Robert P. Law, Ian D. Wall, Richard Lonsdale, Ross P. Hryczanek, Daniel Barker, Tim N. Barrett, Rino A. Bit, John J. Coward, Matthew W. Gray, Darren V. S. Green, Callum J. Hall, Ashley P. Hancock, Carl Haslam, David J. Hirst, Heather F. Hryczanek, Jonathan P. Hutchinson, Semra Kitchen, David Marcus, Jared Marklew, Joseph Mason, Nicholas D. Measom, Margarete Neu, Simon Peace, Alex Phillipou, Stephen D. Pickett, Peter Pogány, James Rowedder, Paul Rowland, Paul Scott-Stevens, Gail A. L. Seal, Hester Sheehan, Efstratios Stratikos, Chloe Tayler, Jonathan A. Taylor, Christopher P. Tinworth, Giovanni Vitulli, "Automated molecular design in BRADSHAW, applied to the optimization of ERAP1 inhibitors", Journal Of Medicinal Chemistry (2026), DOI: 10.1021/acs.jmedchem.5c03071
- Vanda Gunning, Matthew Batchelor, Krista K. Alexander, Martin Walko, Taylor C. Dill, Selena G. Burgess, Stephen J. Royle, Eileen J. Kennedy, Richard Bayliss, "Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction", Structure, 4 (2026), DOI: 10.1016/j.str.2026.04.001
- Edward S. Hems, Joseph A. Wright, Sergey A. Nepogodiev, Rebecca Devine, Corinne J. Arnold, David L. Hughes, Julia E. A. Mundy, Sandra Eltschkner, David M. Lawson, Matthew I. Hutchings, Barrie Wilkinson, "Using X-ray crystallography and 1,n-ADEQUATE NMR to revise the structures of highly substituted aromatic natural products: the absolute configuration of formicamycin congeners", Journal Of Natural Products (2026), DOI: 10.1021/acs.jnatprod.6c00145
- Giulia Alboreggia, Emma L. Atienza, Kendall Muzzarelli, Zahra Assar, Maurizio Pellecchia, "Covalent targeting of histidine residues: a ligand-first approach", Journal Of Medicinal Chemistry (2026), DOI: 10.1021/acs.jmedchem.5c03255
- Dayong Zhou, Lirong Chen, John Rose, Bi-Cheng Wang, "The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase", Acta Crystallographica Section D Structural Biology, 82, 383 - 396 (2026), DOI: 10.1107/S2059798326001968
- Benjamin F. Cooper, Georgia L. Isom, "Optimized bacterial expression of a synthetic BRIL antibody", Acta Crystallographica Section F Structural Biology Communications, 82 (2026), DOI: 10.1107/S2053230X26001548
- Hamish Mitchell, Boguslaw Nocek, Emily J. Guinn, Jerry Y. Y. Heng, "Crystallization and 1.6 Å resolution crystal structure of an acylated GLP-1/GIP analogue peptide", Acta Crystallographica Section F Structural Biology Communications, 82 (2026), DOI: 10.1107/S2053230X26001937
- Stefania Patti, Simone A. De Rose, Michail N. Isupov, Ilya V. Kublanov, Ilaria Magrini Alunno, Sergio Riva, Ivan Bassanini, Eleonora Dore, Christina Stracke, Bettina Siebers, Erica Elisa Ferrandi, Jennifer A. Littlechild, Daniela Monti, "Discovery and characterization of novel 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthase from thermophilic (meta)genomes", Catalysts, 16 (2026), DOI: 10.3390/catal16040305
- Daniel H. O Donovan, Jon Winter-Holt, Gavin W. Collie, Maria E. Cuomo, David J. Mcgarry, Millie Fox, Bo Kyung Alex Seong, Ursula Grazini, Peter Barton, David Longmire, Andrew Lister, Yong Xu, Hazel Mak, Evelyne J. Barrey, Marta Acebrón-García-De-Eulate, Magdalena Richter, Nisha Peter, Maxime Couturier, Gustavo J. Gutierrez, Ryan Guilbert, Wankyu Lee, Pamela A. Lochhead, Argyrides Argyrou, "Targeting the interaction of NRF2 and β-TrCP with molecular glues", Acs Chemical Biology (2026), DOI: 10.1021/acschembio.5c01006
- Malcolm F. White, Stephen A. Mcmahon, Haotian Chi, Shirley Graham, "The CRISPR ring nuclease Csx15 oligomerises on cyclic nucleotide binding to regulate antiviral defence", Biochemical Journal (2026), DOI: 10.1042/BCJ20260019
- [Thesis] Rokas Petrenas, "De novo design of chromophore-binding peptide assemblies and single-chain proteins" (2026)
- Gavin W. Collie, Hazel Mak, Marta Acebron-Garcia-De-Eulate, Argyrides Argyrou, Maxime Couturier, Maria Emanuela Cuomo, Daniel H. O Donovan, Isabella C. Russell, Geoffrey Wells, Jon Winter-Holt, "Structural studies of βTrCP reveal plasticity in binding modes of consensus and nonconsensus degrons", Acs Chemical Biology (2026), DOI: 10.1021/acschembio.5c01007
- Belinda J. Mills, Kyle S. Gregory, Gyles E. Cozier, Supannee Taweechai, Eve Loughlan, Glenn A. Mcconkey, R. Elwyn Isaac, Richard Foster, K. Ravi Acharya, "Hydroxamate-based inhibitors reveal structural determinants of selectivity for Plasmodium falciparum aminopeptidase P", Journal Of Biological Chemistry, 387 (2026), DOI: 10.1016/j.jbc.2026.111372
- De Lin, Luma Godoy Magalhaes, Joel Mcmillan, Thomas Eadsforth, Greg Stewart, Kieran R. Cartmill, Vincent L. G. Postis, Glenn R. Masson, "Residue-level determination of small-molecule-protein affinities by hydrogen-deuterium exchange mass spectrometry", Journal Of The American Society For Mass Spectrometry (2026), DOI: 10.1021/jasms.6c00020
- Ludivine Moine, Wei Hu, Alison Davis, Emanuele Perola, Jian Guo, Kevin Barvian, Yeon Sook Choi, Alexandra Grassian, Joseph L. Kim, Omar K. Ahmad, Thomas A. Dineen, "Design and synthesis of BLU-654, a potent and selective mutant KIT V654A inhibitor for the treatment of imatinib-resistant GIST", Journal Of Medicinal Chemistry, 22 (2026), DOI: 10.1021/acs.jmedchem.5c03554
- Monica C. Rodrigo-Brenni, Jasper C. Komen, Ghaith M. Hamza, Natacha Bohin, Tomas Adomavicius, Angelo Andres, Stefan Blaho, Ulf Börjesson, Gavin W. Collie, Gian Marco De Donatis, Frederik Eisele, Ning Gao, Andrea Gohlke, Christoph Grebner, Frida Gustafsson, Andreas Hock, Cecilia Kankkonen, Praveen Kumar, Emilyanne Leonard, Xin Li, Ruth Macdonald, Katja Madeyski-Bengtson, Eric Miele, Philip Nevin, Jeroen Overman, Fiona Pachl, Claudio Pathe, Matthew W. D. Perry, Christopher Phillips, Andy Pike, Ian Purvis, Timothy Rasmusson, Sophie Regan, Linda Reilly, Jonathan Rose, R. Ian Storer, Jingwen Wang, Xiang Zhai, Iacovos N. Michaelides, Kevin Moreau, "A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader", Nature Communications, 38 (2026), DOI: 10.1038/s41467-026-70663-1
- Eoin Leen, Sharon Yeoh, Eka Sahak, Ellie Mitchell, Gemma Wildsmith, Matthew Batchelor, Antonio N. Calabrese, Gabriele Büchel, Richard Bayliss, "Mechanism of interaction between the transactivation domain of N-myc and the DNA-binding surface of TFIIIC5", Nucleic Acids Research, 54 (2026), DOI: 10.1093/nar/gkag181
- Anissa Haim, Sandra Liebscher, Rasmus Klintrot, Lorenzo Vallino, Marcelo Masman, Andreas H. Simon, Marianne Hahn, Sven Hennig, Saskia Neubacher, Frank Bordusa, Tom N. Grossmann, "Multicyclic D-stereospecific hydrolase dimer with high sustained activity", Angewandte Chemie International Edition, 85 (2026), DOI: 10.1002/anie.202521611
- Javier Abellon-Ruiz, Raul Pacheco-Gomez, Jessica Watts, Adam Hart, Robert P. Hirt, Arnaud Basle, Bert Van Den Berg, "BtuJ1, a surface-exposed B12-binding protein in Bacteroidota, functions as an extracellular vitamin reservoir that enhances fitness", Journal Of Molecular Biology, 375 (2026), DOI: 10.1016/j.jmb.2026.169754
- Arashdeep Kaur, Ruby K. Williams, Shuxin Yang, Mihwa Lee, Niccolay Madiedo Soler, Ethan D. Goddard-Borger, Gideon J. Davies, Mahima Sharma, Spencer J. Williams, "Metal-dependent 2-keto-3,6-dideoxy-6-sulfo-gluconate (KDSG) aldolase: decoding the key C-C bond cleaving step in bacterial sulfoglycolysis", Chemistry – A European Journal, 28 (2026), DOI: 10.1002/chem.70857
- Takeshi Nakama, Aaron Wall, Garry Dolton, Li-Rong Tan, Hannah Thomas, Hiroshi Hamana, Yoshiki Aritsu, Toong Seng Tan, Mako Toyoda, Yoshihiko Goto, Huanyu Li, Mizuki Kitamatsu, Keiko Udaka, Yusuke Miyashita, Hiroyuki Oshiumi, Kimitoshi Nakamura, Yoji Nagasaki, Rumi Minami, Hirotomo Nakata, Pierre J. Rizkallah, Hiroyuki Kishi, Takamasa Ueno, Andrew K. Sewell, Chihiro Motozono, "Position-5-driven reorientation of an immunodominant HLA-A*24:02 SARS-CoV-2 epitope drives universal T-cell escape", Jci Insight (2026), DOI: 10.1172/jci.insight.202235
- Fabiana Izidro A. L. Layng, Huiyu Ren, Nicole A. Bakas, Dhanya R. Panickar, Lester J. Lambert, Maria Celeridad, Jiaqian Wu, Laurent De Backer, Preeti Chandrachud, Allison S. Limpert, Mitchell Vamos, Apirat Chaikuad, Betsaida B. Verdugo, Patrick M. Hagan, Sonja N. Brun, Lutz Tautz, Stefan Knapp, Reuben J. Shaw, Guy S. Salvesen, Douglas J. Sheffler, Nicholas D. P. Cosford, "Synthesis and characterization of ULK1/2 kinase inhibitors that inhibit autophagy and upregulate expression of major histocompatibility complex I for the treatment of non-small cell lung cancer", Acs Chemical Biology (2026), DOI: 10.1021/acschembio.5c00711
- Ziwei Liu, Dom Bellini, Fabrice Gorrec, Armin Wagner, Kamel El Omari, John D. Sutherland, "Crystal structure of a tRNA acceptor-stem mimic at 1.94 Å resolution", Acta Crystallographica Section F Structural Biology Communications, 82, 57 - 65 (2026), DOI: 10.1107/S2053230X26000658
- Harry M. Williams, Alastair Watson, Jens Madsen, Howard W. Clark, Derek W. Hood, Stefan Oscarson, Trevor J. Greenhough, Annette K. Shrive, "Phosphorylation of inner core heptose is a major determinant of bacterial surface lipopolysaccharide recognition by the innate immune protein hSP-D", Journal Of Biological Chemistry, 164 (2026), DOI: 10.1016/j.jbc.2026.111307
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