Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
138 items found for 2025 [total: 2283]
An allantoin-inducible glyoxylate utilization pathway in Pseudomonas aeruginosa Microbiology, 171 Dec 2025 DOI: 10.1099/mic.0.001635
Synthesis, photochemical and biological evaluation of novel photoswitchable glycomimetic ligands of Pseudomonas aeruginosa LecB Rsc Advances, 15 Dec 2025 DOI: 10.1039/D5RA06897E
On the mechanism of K+ transport through the inter-subunit tunnel of KdpFABC Journal Of General Physiology, 158 Dec 2025 DOI: 10.1085/jgp.202513794
Optimization and chemoproteomic profiling of a selective, covalent Bfl-1-targeting cellular tool Journal Of Medicinal Chemistry, 2021 Dec 2025 DOI: 10.1021/acs.jmedchem.5c02581
Journal Paper I04-Macromolecular Crystallography
Chymotrypsin digestion analysis of glycyl radical and B12-dependent radical enzymes indicates common substrate-induced structural shifts Scientific Reports, 52 Dec 2025 DOI: 10.1038/s41598-025-28641-y
KHNYN is a manganese-dependent endoribonuclease required for ZAP-mediated antiviral restriction Nucleic Acids Research, 53 Dec 2025 DOI: 10.1093/nar/gkaf1360
Discovery and characterization of diverse non-nucleotide inhibitors of DNPH1 using an integrated hit finding strategy Acs Medicinal Chemistry Letters, Dec 2025 DOI: 10.1021/acsmedchemlett.5c00651
Journal Paper I04-Macromolecular Crystallography
Structure and mechanism of the broad spectrum CRISPR-associated ring nuclease Crn4 Nature Communications, 18 Dec 2025 DOI: 10.1038/s41467-025-67607-6
Targeting Tenascin-C-Toll-like Receptor 4 signalling with Adhiron-derived small molecules - a viable strategy for reducing fibrosis in systemic sclerosis Bioorganic Chemistry, 167 Dec 2025 DOI: 10.1016/j.bioorg.2025.109251
Consequences of peptide macrocyclization revealed by virus-inspired β-hairpin mimetics Acs Chemical Biology, 567 Dec 2025 DOI: 10.1021/acschembio.5c00834
Fluorescent binding assay for allosteric ligands of liver pyruvate kinase European Journal Of Medicinal Chemistry, 298 Nov 2025 DOI: 10.1016/j.ejmech.2025.117989
State-selective small molecule degraders that preferentially remove aggregates and oligomers Nature Communications, 16 Nov 2025 DOI: 10.1038/s41467-025-65454-z
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Understanding mechanisms of nuclear transport during viral infection Nov 2025
Thesis B21-High Throughput SAXS I04-Macromolecular Crystallography
Use of direct-to-biology strategies for the discovery of 2′-deoxynucleoside 5′-monophosphate N-glycosidase (DNPH1) PROTACs Journal Of Medical Chemistry, 68 Nov 2025 DOI: 10.1021/acs.jmedchem.5c02337
Journal Paper I04-Macromolecular Crystallography
A viral SAVED protein with ring nuclease activity degrades the CRISPR second messenger cA4 Biochemical Journal, 482 Nov 2025 DOI: 10.1042/BCJ20253271
Ribonuclease toxin RelE1 inhibits growth of Mycobacterium tuberculosis through specific cleavage of the ribosomal anti-Shine-Dalgarno region Nucleic Acids Research, 53 Nov 2025 DOI: 10.1093/nar/gkaf1070
The novel GlcNAc 6-phosphate dehydratase NagS governs a metabolic checkpoint that controls nutrient signaling in Streptomyces Plos Biology, 23 Nov 2025 DOI: 10.1371/journal.pbio.3003514
Talin-tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation Journal Of Cell Biology, 225 Nov 2025 DOI: 10.1083/jcb.202503155
Coordination of a dirhodium(II) center to methionine and cysteine side chains: evidence from X-ray structure of the adduct formed by dirhodium tetraacetate with a C-phycocyanin International Journal Of Molecular Sciences, 26 Nov 2025 DOI: 10.3390/ijms262311492
Discovery and optimization of a non-nucleoside-based series of inhibitors of 2′-deoxynucleoside 5′-monophosphate glycosidase (DNPH1) Journal Of Medical Chemistry, Nov 2025 DOI: 10.1021/acs.jmedchem.5c02356
Identification and characterization of botulinum neurotoxin–like two-component toxins in Paeniclostridium ghonii Science Advances, 11 Nov 2025 DOI: 10.1126/sciadv.adx6145
Directed evolution of a beta‐lactamase samples a wide variety of conformational states Protein Science, 34 Nov 2025 DOI: 10.1002/pro.70322
Biocatalytic activation of sulfur heteroaromatics facilitates dearomatizing cross-couplings to set stereogenic centers or axes Journal Of The American Chemical Society, Nov 2025 DOI: 10.1021/jacs.5c16261
Journal Paper I04-Macromolecular Crystallography
An asymmetric hydrogen atom transferase with an abiological thiophenol cofactor Journal Of The American Chemical Society, Nov 2025 DOI: 10.1021/jacs.5c12516
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The structure and function of extracellular redox enzymes Nov 2025
Thesis B21-High Throughput SAXS I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A fragment-based electrophile-first approach to target histidine with aryl-fluorosulfates: application to hMcl-1 Journal Of Medical Chemistry, Nov 2025 DOI: 10.1021/acs.jmedchem.5c02199
Design of bicyclic peptide tandems mimicking the homodimeric GDF15 protein to inhibit GDF15-GFRaL-RET complex cell signaling Journal Of Medicinal Chemistry, 647 Oct 2025 DOI: 10.1021/acs.jmedchem.5c01378
Yersinia ruckeri YRB periplasmic binding protein YiuA selectively recognizes a Fe(iii)-mono-catecholate siderophore Chemical Communications, 3 Oct 2025 DOI: 10.1039/D5CC05103G
Using dose aware and unattended data collection modes on the variable and microfocus macromolecular crystallography beamline I04 at Diamond Light Source Oct 2025 DOI: 10.1063/4.0000904
Advances of 3D microcrystals electron diffraction for transmembrane protein structure determination Biophysical Journal, Oct 2025 DOI: 10.1016/j.bpj.2025.10.027
Improved nucleoside (2′-deoxy)ribosyltransferases maximize enzyme promiscuity while maintaining catalytic efficiency Acs Chemical Biology, 20 Oct 2025 DOI: 10.1021/acschembio.5c00120
Accelerating synchrotron MX beamlines: automated sample centering with machine learning and Bluesky orchestration Oct 2025 DOI: 10.1063/4.0000839
Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors Biochemical Journal, 482 Oct 2025 DOI: 10.1042/BCJ20253358
Glycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells Proceedings Of The National Academy Of Sciences, 122 Oct 2025 DOI: 10.1073/pnas.2521209122
Comparative structural analysis of Escherichia Coli cyay at room and cryogenic temperatures using macromolecular and serial crystallography Chembiochem, Oct 2025 DOI: 10.1002/cbic.202500442
Accelerated in silico discovery of SGR-1505: A potent MALT1 allosteric inhibitor for the treatment of mature B-cell malignancies Journal Of Medicinal Chemistry, Oct 2025 DOI: 10.1021/acs.jmedchem.5c01494
Journal Paper I04-Macromolecular Crystallography
Probing the molecular determinants of Ty1 retrotransposon restriction specificity in yeast Plos Genetics, 21 Oct 2025 DOI: 10.1371/journal.pgen.1011898
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Exploiting the cryptic αd pocket of casein kinase 2α (CK2α) to deliver highly potent and selective Type 1 inhibitors Journal Of Medicinal Chemistry, Oct 2025 DOI: 10.1021/acs.jmedchem.5c01807
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
StayRose: a photostable StayGold derivative red-shifted by genetic code expansion Journal Of Biological Chemistry, 40 Oct 2025 DOI: 10.1016/j.jbc.2025.110832
A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum Molecular Cell, Oct 2025 DOI: 10.1016/j.molcel.2025.09.032
A 3.3-Å cryo-EM structure of an engineered high-affinity human prothrombinase complex Blood, Oct 2025 DOI: 10.1182/blood.2025031527
Structural basis for inhibition of Mycobacterium tuberculosis α-methylacyl-CoA racemase by 2-arylthiopropanoyl-CoA inhibitor analogs Journal Of Biological Chemistry, Oct 2025 DOI: 10.1016/j.jbc.2025.110848
Structure and analysis of a virulent chitinase from Listeria monocytogenes Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, 1874 Oct 2025 DOI: 10.1016/j.bbapap.2025.141106
Phosphorylation as a candidate regulatory mechanism for effector recruitment to tankyrase Royal Society Open Science, 12 Oct 2025 DOI: 10.1098/rsos.250824
The cytochrome P450 decarboxylase from Staphylococcus aureus can produce a diene from a C18 monounsaturated fatty acid: A spectroscopic, structural and kinetic characterisation Journal Of Inorganic Biochemistry, 275 Oct 2025 DOI: 10.1016/j.jinorgbio.2025.113117
Crystal structure of Candida antarctica Lipase B with a putative pro-peptide region Crystals, 15 Oct 2025 DOI: 10.3390/cryst15110927
Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities Pest Management Science, 148 Sept 2025 DOI: 10.1002/ps.70199
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Exploiting ALDH1A2 and ALDH1A3 isoform variability for crystallisation screening Biochemical And Biophysical Research Communications, 780 Sept 2025 DOI: 10.1016/j.bbrc.2025.152469
Discovery of AZD8421: A potent CDK2 inhibitor with selectivity against other CDK family members and the human kinome Journal Of Medicinal Chemistry, Sept 2025 DOI: 10.1021/acs.jmedchem.5c01478
Journal Paper I04-Macromolecular Crystallography
Focused structure-based virtual screening identifies novel inhibitors of SOS1 Acs Medicinal Chemistry Letters, 16 Sept 2025 DOI: 10.1021/acsmedchemlett.5c00302
Journal Paper I04-Macromolecular Crystallography
Tumour-specific STING agonist synthesis via a two-component prodrug system Nature Chemistry, 21 Sept 2025 DOI: 10.1038/s41557-025-01930-9
Design, modular synthesis and screening of 58 shape-diverse 3-D fragments Chemical Science, Sept 2025 DOI: 10.1039/D5SC05819H
Detection and characterisation of ligand-induced conformational changes in acetylcholine binding proteins using biosensors and X-ray crystallography Rsc Chemical Biology, Aug 2025 DOI: 10.1039/D5CB00041F
Discovery of small-molecule ligands for the E3 ligase STUB1/CHIP from a DNA-encoded library screen Acs Medicinal Chemistry Letters, 16 Aug 2025 DOI: 10.1021/acsmedchemlett.5c00361
Journal Paper I04-Macromolecular Crystallography
Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 Science Advances, 11 Aug 2025 DOI: 10.1126/sciadv.adx2434
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue Life Science Alliance, 8 Aug 2025 DOI: 10.26508/lsa.202503394
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Potent fluorescent probe for target-engagement studies of allosteric pyruvate kinase modulators Angewandte Chemie International Edition, 3 Aug 2025 DOI: 10.1002/anie.202513969
Functional and structural insights into a thermostable (S)-selective amine transaminase and its improved substrate scope by protein engineering Applied Microbiology And Biotechnology, 109 Aug 2025 DOI: 10.1007/s00253-025-13536-9
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat The Febs Journal, 8 Aug 2025 DOI: 10.1111/febs.70232
De novo designed 3-helix bundle peptides and proteins with controlled topology and stability Chemical Science, Aug 2025 DOI: 10.1039/D5SC05576H
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase Communications Biology, 8 Aug 2025 DOI: 10.1038/s42003-025-08587-7
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I23-Long wavelength MX open access
Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases Rsc Medicinal Chemistry, Aug 2025 DOI: 10.1039/D5MD00512D
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
High-throughput evaluation of novel WRN inhibitors Slas Discovery, 7 Aug 2025 DOI: 10.1016/j.slasd.2025.100266
A CD1c lipid agnostic T cell receptor bispecific engager redirects T cells against CD1c+ cells Frontiers In Immunology, 16 Jul 2025 DOI: 10.3389/fimmu.2025.1614610
Conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis Nature Communications, 16 Jul 2025 DOI: 10.1038/s41467-025-60593-9
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Characterization of cryo-cooled silicon crystal monochromators via measurement of flux versus power Journal Of Synchrotron Radiation, 32 Jul 2025 DOI: 10.1107/S160057752500342X
Journal Paper I04-Macromolecular Crystallography I07-Surface & interface diffraction I18-Microfocus Spectroscopy I19-Small Molecule Single Crystal Diffraction open access
Structural basis of topoisomerase targeting by delafloxacin Nature Communications, 16 Jul 2025 DOI: 10.1038/s41467-025-60688-3
Biochemical and structural insights into GMHpaB: A thermostable 4-Hydroxyphenylacetate-3-monooxygenase with dual cofactor versatility International Journal Of Biological Macromolecules, 19 Jul 2025 DOI: 10.1016/j.ijbiomac.2025.146065
Journal Paper I04-Macromolecular Crystallography
A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily Nature Communications, 16 Jul 2025 DOI: 10.1038/s41467-025-61633-0
Macrocyclization of backbone N-methylated peptides by a prolyl oligopeptidase with a distinctive substrate recognition mechanism Chemical Science, 57 Jul 2025 DOI: 10.1039/D5SC03723A
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease Science Translational Medicine, 17 Jul 2025 DOI: 10.1126/scitranslmed.adu4564
Journal Paper I04-Macromolecular Crystallography
Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism Journal Of Medicinal Chemistry, Jul 2025 DOI: 10.1021/acs.jmedchem.5c00478
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Regulation of a phage defence island by RptR, a novel repressor that controls restriction–modification systems in diverse bacteria Nucleic Acids Research, 53 Jul 2025 DOI: 10.1093/nar/gkaf645
Ciprofloxacin inhibits Angiotensin I-Converting Enzyme (ACE) activity by binding at the exosite, distal to the catalytic pocket Acs Bio & Med Chem Au, 5 June 2025 DOI: 10.1021/acsbiomedchemau.5c00089
PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin Elife, 13 June 2025 DOI: 10.7554/eLife.103403
Structural mechanisms of multimeric BTB E3 ligases and interactors June 2025
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Discovery of inhibitors for bacterial Arr enzymes ADP-ribosylating and inactivating rifamycin antibiotics Acs Chemical Biology, June 2025 DOI: 10.1021/acschembio.5c00164
Journal Paper I04-Macromolecular Crystallography
The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound Nature Microbiology, 10 June 2025 DOI: 10.1038/s41564-025-02017-4
Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination Chemical Science, 28 May 2025 DOI: 10.1039/D5SC01540E
Rational selection of the monoclonal α-synuclein antibody amlenetug (Lu AF82422) for the treatment of α-synucleinopathies Npj Parkinson'S Disease, 11 May 2025 DOI: 10.1038/s41531-024-00849-1
Fragment-based drug discovery for transthyretin kinetic stabilisers using a novel capillary zone electrophoresis method Plos One, 20 May 2025 DOI: 10.1371/journal.pone.0323816
Journal Paper B23-Circular Dichroism I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural enzymological studies of the long chain fatty acyl-CoA synthetase FadD5 from the mce1 operon of Mycobacterium tuberculosis Biochemical And Biophysical Research Communications, 148 May 2025 DOI: 10.1016/j.bbrc.2025.151960
Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia Molecular Therapy, May 2025 DOI: 10.1016/j.ymthe.2025.04.042
A combined methodology for radiation damage mitigation and enzyme intermediate study in macromolecular crystals May 2025 DOI: 10.25392/leicester.data.29155316.v1
Thesis I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography VMXm-Versatile Macromolecular Crystallography microfocus
Repurposing human Carbonic Anhydrase 2 for artificial photosynthesis: structural and functional role of selected transition metals May 2025
Thesis I04-Macromolecular Crystallography
Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance Chemical Science, 5 May 2025 DOI: 10.1039/D5SC00964B
Filamin C dimerisation is regulated by HSPB7 Nature Communications, 16 May 2025 DOI: 10.1038/s41467-025-58889-x
Characterization of a two-component kinase that initiates the bacterial catabolism of hydroxyphenylethanones Journal Of Biological Chemistry, 9 May 2025 DOI: 10.1016/j.jbc.2025.110210
Identification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target Proceedings Of The National Academy Of Sciences, 122 May 2025 DOI: 10.1073/pnas.2424388122
Microfocus and variable beam size at the Diamond Light Source I04 beamline May 2025 DOI: 10.1088/1742-6596/3010/1/012051
Conference Paper I04-Macromolecular Crystallography
Dose aware data collection on the variable and microfocus macromolecular crystallography beamline I04 at Diamond Light Source May 2025 DOI: 10.1088/1742-6596/3010/1/012096
Conference Paper I04-Macromolecular Crystallography
Structures of α-galactosaminidases from the CAZy GH114 family and homologs defining a new GH191 family of glycosidases Acta Crystallographica Section D Structural Biology, 81 May 2025 DOI: 10.1107/S2059798325002864
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Molecular basis of acyl-CoA ester recognition by α-methylacyl-CoA racemase from Mycobacterium tuberculosis Journal Of Biological Chemistry, 275 May 2025 DOI: 10.1016/j.jbc.2025.110302
A generic cross-seeding approach to protein crystallization Journal Of Applied Crystallography, 58 Apr 2025 DOI: 10.1107/S1600576725000457
Observation of the assembly of the nascent mineral core at the nucleation site of human mitochondrial ferritin Journal Of The American Chemical Society, Apr 2025 DOI: 10.1021/jacs.5c01337
Structural and antigen-binding surface definition of an anti-CD93 monoclonal antibody for the treatment of degenerative vascular eye diseases International Journal Of Biological Macromolecules, 77 Apr 2025 DOI: 10.1016/j.ijbiomac.2025.143118
Structure and catalytic mechanism of methylisocitrate lyase, a potential drug target against Coxiella burnetii Journal Of Biological Chemistry, 42 Apr 2025 DOI: 10.1016/j.jbc.2025.108517
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and functional significance of Aedes aegypti AgBR1 flavivirus immunomodulator Journal Of Virology, Apr 2025 DOI: 10.1128/jvi.01878-24
Molecular basis of dipeptide recognition in Drosophila melanogaster Angiotensin I-converting enzyme homologue, AnCE Biomolecules, 15 Apr 2025 DOI: 10.3390/biom15040591
Macrocyclic peptide probes for immunomodulatory protein CD59: potent modulators of bacterial toxin activity and antibody-dependent cytotoxicity Angewandte Chemie International Edition, Apr 2025 DOI: 10.1002/anie.202422673
Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding Communications Chemistry, 8 Apr 2025 DOI: 10.1038/s42004-025-01501-6
Comparative analysis of STP6 and STP10 unravels molecular selectivity in sugar transport proteins Proceedings Of The National Academy Of Sciences, 122 Apr 2025 DOI: 10.1073/pnas.2417370122
Morita–Baylis–Hillman adduct chemistry as a tool for the design of lysine-targeted covalent ligands Acs Medicinal Chemistry Letters, 16 Mar 2025 DOI: 10.1021/acsmedchemlett.4c00479
Journal Paper I04-Macromolecular Crystallography
Rational engineering of a thermostable α-oxoamine synthase biocatalyst expands the substrate scope and synthetic applicability Communications Chemistry, 8 Mar 2025 DOI: 10.1038/s42004-025-01448-8
Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor Frontiers In Immunology, 16 Mar 2025 DOI: 10.3389/fimmu.2025.1547664
Structure of the outer membrane transporter fema and its role in the uptake of ferric dihydro-aeruginoic acid and ferric aeruginoic acid in Pseudomonas aeruginosa Acs Chemical Biology, Mar 2025 DOI: 10.1021/acschembio.4c00820
Expansion of the diversity of dispersin scaffolds Acta Crystallographica Section D Structural Biology, 81 Mar 2025 DOI: 10.1107/S205979832500110X
Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity Nature Communications, 16 Mar 2025 DOI: 10.1038/s41467-025-57532-z
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Bacterial transcriptional repressor NrdR - a flexible multifactorial nucleotide sensor The Febs Journal, Mar 2025 DOI: 10.1111/febs.70037
MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks Life Science Alliance, 8 Mar 2025 DOI: 10.26508/lsa.202403074
The Medicago truncatula LYR 4 intracellular domain serves as a scaffold in immunity signaling independent of its phosphorylation activity New Phytologist, 118 Mar 2025 DOI: 10.1111/nph.70067
Discovery of mono-ADP ribosylating toxins with high structural homology to Pseudomonas exotoxin A Communications Biology, 8 Mar 2025 DOI: 10.1038/s42003-025-07845-y
Discovery of a series of covalent ligands that bind to Cys77 of the Von Hippel–Lindau Tumor Suppressor Protein (VHL) Acs Medicinal Chemistry Letters, Mar 2025 DOI: 10.1021/acsmedchemlett.4c00582
Journal Paper I04-Macromolecular Crystallography
Pseudomonas aeruginosa PfpI is a methylglyoxalase Journal Of Biological Chemistry, 2 Mar 2025 DOI: 10.1016/j.jbc.2025.108374
Sequence rules for a long SPOP-binding degron required for protein ubiquitylation Biochemical Journal, Mar 2025 DOI: 10.1042/BCJ20253041
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Design of orthogonal constant domain interfaces to aid proper heavy/light chain pairing of bispecific antibodies Mabs, 17 Mar 2025 DOI: 10.1080/19420862.2025.2479531
Reversible small molecule multivariant ras inhibitors display tunable affinity for the active and inactive forms of Ras Journal Of Medicinal Chemistry, 49 Mar 2025 DOI: 10.1021/acs.jmedchem.4c02929
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Determining T-cell receptor binding orientation and Peptide-HLA interactions using cross-linking mass spectrometry Journal Of Biological Chemistry, 20 Mar 2025 DOI: 10.1016/j.jbc.2025.108445
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Characterization of a second class Ie ribonucleotide reductase Communications Biology, 8 Feb 2025 DOI: 10.1038/s42003-025-07565-3
Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel Proceedings Of The National Academy Of Sciences, 122 Feb 2025 DOI: 10.1073/pnas.2421623122
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN Journal Of Biological Chemistry, 297 Feb 2025 DOI: 10.1016/j.jbc.2025.108336
Structure and activity of a phosphinothricin N-acetyltransferase (PSPTO_3321) from Pseudomonas syringae pv. tomato DC3000 Biochemical And Biophysical Research Communications, 6 Feb 2025 DOI: 10.1016/j.bbrc.2025.151539
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
MTA-cooperative PRMT5 inhibitors: mechanism switching through structure-based design Journal Of Medicinal Chemistry, 68 Feb 2025 DOI: 10.1021/acs.jmedchem.4c01998
Sulfoglycolysis sustains Eubacterium rectale in low-fiber diets Journal Of Biological Chemistry, 473 Feb 2025 DOI: 10.1016/j.jbc.2025.108320
Virtual fragment screening for DNA repair inhibitors in vast chemical space Nature Communications, 16 Feb 2025 DOI: 10.1038/s41467-025-56893-9
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy Nature Communications, 16 Feb 2025 DOI: 10.1038/s41467-025-56213-1
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability Nucleic Acids Research, 53 Feb 2025 DOI: 10.1093/nar/gkaf019
Discovery and optimization of pyrazine carboxamide AZ3246, a selective HPK1 inhibitor Journal Of Medicinal Chemistry, Feb 2025 DOI: 10.1021/acs.jmedchem.4c02631
Journal Paper I04-Macromolecular Crystallography
Investigation into the effect of phenylalanine gating on anaerobic haem breakdown using the energy landscape approach Protein Science, 34 Feb 2025 DOI: 10.1002/pro.5243
Structural enzymology of spirotetronate cyclases Feb 2025
Thesis I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Molecular basis of human angiotensin‐1 converting enzyme inhibition by a series of diprolyl‐derived compounds The Febs Journal, 389 Jan 2025 DOI: 10.1111/febs.17384
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Development of D-box peptides to inhibit the anaphase promoting complex/cyclosome Elife, Jan 2025 DOI: 10.7554/eLife.104238
Investigating the consequences of substituting histidine ligands to hemes in the decaheme cytochrome MtrC Jan 2025
Thesis I04-Macromolecular Crystallography
Capture, mutual inhibition and release mechanism for aPKC–Par6 and its multisite polarity substrate Lgl Nature Structural & Molecular Biology, 23 Jan 2025 DOI: 10.1038/s41594-024-01425-0
Confinement and catalysis within de novo designed peptide barrels Journal Of The American Chemical Society, Jan 2025 DOI: 10.1021/jacs.4c16633
A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements Nature Communications, 16 Jan 2025 DOI: 10.1038/s41467-025-56199-w
Highly optimized CNS penetrant inhibitors of EGFR Exon20 insertion mutations Journal Of Medicinal Chemistry, Jan 2025 DOI: 10.1021/acs.jmedchem.4c02811
Journal Paper I04-Macromolecular Crystallography
UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia Life Science Alliance, 8 Jan 2025 DOI: 10.26508/lsa.202403066
- Susannah L. Parkhill, Olivia Little, Isabel Askenasy, Edoardo Labrini, Meng Wang, Paul D. Brear, Wei Cai, Tomas Deingruber, Tianyi Yang, David R. Spring, Martin Welch, "An allantoin-inducible glyoxylate utilization pathway in Pseudomonas aeruginosa", Microbiology, 171 (2025), DOI: 10.1099/mic.0.001635
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- [Thesis] Emily Cross, "Understanding mechanisms of nuclear transport during viral infection" (2025)
- Niall A. Anderson, Bernard Barlaam, Argyrides Argyrou, Peter C. Astles, Hanna Bruss, Elaine B. Cadogan, Luca Carlino, Luz Alonso-Crisostomo, Gavin W. Collie, Alex J. Edwards, Anastasiia Gryniukova, James Hall, Kunzah Jamal, Joshua Kent, Linda Kitching, Christopher Kourra, Carolyn Lam, Alexander G. Milbradt, Jenni Nikkilä, Sarah Northall, Mark J. O’connor, Jeroen Overman, Claudio Pathe, Wendy Savory, Daniel Slade, Jonathan A. Spencer, Darren Stead, Christopher J. Stubbs, Benjamin C. Whitehurst, Sabrina Winfield, "Use of direct-to-biology strategies for the discovery of 2′-deoxynucleoside 5′-monophosphate N-glycosidase (DNPH1) PROTACs", Journal Of Medical Chemistry, 68 (2025), DOI: 10.1021/acs.jmedchem.5c02337
- Marta Orzechowski, Ville Hoikkala, Haotian Chi, Stephen Mcmahon, Tracey Gloster, Malcolm F. White, "A viral SAVED protein with ring nuclease activity degrades the CRISPR second messenger cA4", Biochemical Journal, 482 (2025), DOI: 10.1042/BCJ20253271
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- Chao Li, Mia Urem, Ioli Kotsogianni, Josephine Lau, Chao Du, Somayah S. Elsayed, Nathaniel I. Martin, Iain W. Mcnae, Patrick Voskamp, Christoph Mayer, Sébastien Rigali, Navraj Pannu, Jan P. Abrahams, Lennart Schada Von Borzyskowski, Gilles P. Van Wezel, "The novel GlcNAc 6-phosphate dehydratase NagS governs a metabolic checkpoint that controls nutrient signaling in Streptomyces", Plos Biology, 23 (2025), DOI: 10.1371/journal.pbio.3003514
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- Bernard Barlaam, Luz Alonso-Crisostomo, Niall A. Anderson, Argyrides Argyrou, Peter C. Astles, Elaine B. Cadogan, Luca Carlino, Gavin W. Collie, Nichola L. Davies, James Hall, Linda Kitching, Xianxi Li, Filippos Michopoulos, Alexander G. Milbradt, Jenni Nikkilä, Sarah Northall, Mark J. O'Connor , Xiaohiu Pei, Joseph Shaw, Danial Slade, Harriet Southgate, Darren Stead, Christopher J. Stubbs, Benjamin C. Whitehurst, Bin Xing, Yihao Yuan, Jie Zhou, "Discovery and optimization of a non-nucleoside-based series of inhibitors of 2′-deoxynucleoside 5′-monophosphate glycosidase (DNPH1)", Journal Of Medical Chemistry (2025), DOI: 10.1021/acs.jmedchem.5c02356
- Pyung-Gang Lee, Linxiang Yin, Xin Wei, Jingyuan Shi, Geoffrey Masuyer, Travis G. Wentz, Pengsheng Chen, Ying Xu, Junjie Liang, Haonan Zhang, Sara Persson Kosenina, Briallen Lobb, Michael Mansfield, Sarjeet S. Gill, Sabine Pellett, Pal Stenmark, Andrew C. Doxey, Min Dong, "Identification and characterization of botulinum neurotoxin–like two-component toxins in Paeniclostridium ghonii", Science Advances, 11 (2025), DOI: 10.1126/sciadv.adx6145
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- Anthony P. Green, David J. Procter, Órla Conboy, Emily Q. Rushworth, Christopher J. Taylor , Colin Levy, Mary Ortmayer, George F. S. Whitehead, Andy Yen, Ciro Roman, "Biocatalytic activation of sulfur heteroaromatics facilitates dearomatizing cross-couplings to set stereogenic centers or axes", Journal Of The American Chemical Society (2025), DOI: 10.1021/jacs.5c16261
- Hui Cao, Thomas R. Ward, Kailin Zhang, Vladimir Gorbachev, Tobias Vornholt, Kun Yu, Dongping Chen, "An asymmetric hydrogen atom transferase with an abiological thiophenol cofactor", Journal Of The American Chemical Society (2025), DOI: 10.1021/jacs.5c12516
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- Giulia Alboreggia, Kendall Muzzarelli, Zahra Assar, Maurizio Pellecchia, "A fragment-based electrophile-first approach to target histidine with aryl-fluorosulfates: application to hMcl-1", Journal Of Medical Chemistry (2025), DOI: 10.1021/acs.jmedchem.5c02199
- Anaïs F. M. Noisier, Jenny Sandmark, Fredrik Edfeldt, Anna Backmark, Johan Broddefalk, Joanna Wandzik, Ulrik Jurva, Margareta Ek, Carina A. Johansson, Louise Barlind, Jenny Gunnarsson, Janna M. Bigalke, Yafeng Xue, Andrey I. Frolov, Cecilia Kankkonen, Robert G. Roth, Maria Fritsch, Sophie Watcham, Katerine Van Rietschoten, Gemma E. Mudd, Helen Harrison, Liuhong Chen, Michael J. Skynner, David J. Craik, Sunay V. Chankeshwara, Malin Lemurell, "Design of bicyclic peptide tandems mimicking the homodimeric GDF15 protein to inhibit GDF15-GFRaL-RET complex cell signaling", Journal Of Medicinal Chemistry, 647 (2025), DOI: 10.1021/acs.jmedchem.5c01378
- Emil Thomsen, Seán Thompson, Parker R. Stow, Maren Cukor, Gideon Grogan, Anne-K. Duhme-Klair, Alison Butler, "Yersinia ruckeri YRB periplasmic binding protein YiuA selectively recognizes a Fe(iii)-mono-catecholate siderophore", Chemical Communications, 3 (2025), DOI: 10.1039/D5CC05103G
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- Anastasia Polycarpou, Tara Wagner-Gamble, Roseanna Greenlaw, Lauren O'Neill, Varsha Kanabar, Alanoud Alrehaili, Yusun Jeon, Jonathan Baker, Mona Bafadhel, Hataf Khan, Michael H. Malim, Marco Romano, Conrad A. Farrar, Dorota Smolarek, Rocio Martinez-Nunez, Katie J. Doores, Russell Wallis, Linda S. Klavinskis, Steven H. Sacks, "Glycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells", Proceedings Of The National Academy Of Sciences, 122 (2025), DOI: 10.1073/pnas.2521209122
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- Paul A. Glossop, Paul Brear, Susanne Wright, Neil Flanagan, Melanie S. Glossop, Charlotte A. L. Lane, Richard P. Butt, David R. Spring, Marko Hyvonen, Darren Cawkill, "Exploiting the cryptic αd pocket of casein kinase 2α (CK2α) to deliver highly potent and selective Type 1 inhibitors", Journal Of Medicinal Chemistry (2025), DOI: 10.1021/acs.jmedchem.5c01807
- Will Scott, Esther Ivorra-Molla, Dipayan Akhuli, Teresa Massam-Wu, Pawel K. Lysyganicz, Rylie Walsh, Matthew Parent, Jonathan Cook, Lijiang Song, Abhishek Kumar, Falk Schneider, Masanori Mishima, Allister Crow, Mohan K. Balasubramanian, "StayRose: a photostable StayGold derivative red-shifted by genetic code expansion", Journal Of Biological Chemistry, 40 (2025), DOI: 10.1016/j.jbc.2025.110832
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- Conchita Fraguas Bringas, Mohd Syed Ahanger, Joyceline Cuenco, Hongling Liu, Alex B. Addinsall, Maria Lindahl, Ashley J. Ovens, Mark A. Febbraio, Marc Foretz, Olga Göransson, John W. Scott, Elton Zeqiraj, Kei Sakamoto, "Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827", Science Advances, 11 (2025), DOI: 10.1126/sciadv.adx2434
- Mark A. Nakasone, Lori Buetow, Mads Gabrielsen, Syed F. Ahmed, Karolina A. Majorek, Gary J. Sibbet, Brian O. Smith, Danny T. Huang, "Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue", Life Science Alliance, 8 (2025), DOI: 10.26508/lsa.202503394
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- Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya, "Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat", The Febs Journal, 8 (2025), DOI: 10.1111/febs.70232
- Xiyue Leng, Katherine I. Albanese, Lia R. Golub, Arthur A. Norman, Jonathan Clayden, Derek Woolfson, "De novo designed 3-helix bundle peptides and proteins with controlled topology and stability", Chemical Science (2025), DOI: 10.1039/D5SC05576H
- Jessica Domenech, Nuttawan Pramanpol, Claudine Bisson, Sveta E. Sedelnikova, Joshua R. Barrett, Abdul A. A. B. Dakhil, Vitaliy Mykhaylyk, Ali S. Abdelhameed, Stephen E. Harding, David W. Rice, Patrick J. Baker, Juan Ferrer, "Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase", Communications Biology, 8 (2025), DOI: 10.1038/s42003-025-08587-7
- Joseph F. Hoff, Kirsty E. Goudar, Karina Calvopina, Michael Beer, Philip Hinchliffe, John M. Shaw, Catherine L. Tooke, Yuiko Takebayashi, Andrew F. Cadzow, Nicholas Harmer, Adrian J. Mulholland, Christopher J. Schofield, James Spencer, "Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases", Rsc Medicinal Chemistry (2025), DOI: 10.1039/D5MD00512D
- Haiyan Xu, Rachel L. Palte, Meredith M. Rickard, Soon Woo Kwon, Xiaomei Chai, Jing Yuan, John Bassett, Joseph Moran, Markus Koglin, Isaac Musisi, Minjia Zhang, Klaus Maskos, Marcel J. Tauchert, Yu-Shan Cheng, Zixiong Wang, Yi Yang, Abhisek Banerjee, Joanna L. Chen, Indu Bharathan, Lorena Rico, Kaitlyn Logan, My Sam Mansueto, Stuart Shumway, Joey L. Methot, Robert J. Bauer, "High-throughput evaluation of novel WRN inhibitors", Slas Discovery, 7 (2025), DOI: 10.1016/j.slasd.2025.100266
- Rita Szoke-Kovacs, Sophie Khakoo, Victor Lopes Rangel, Pietro Della Cristina, Johanne Pentier, Rahul Khanolkar, Sam El-Ajouz, Robert Simmons, David K. Cole, Peter Gogolak, Mariolina Salio, Vijaykumar Karuppiah, "A CD1c lipid agnostic T cell receptor bispecific engager redirects T cells against CD1c+ cells", Frontiers In Immunology, 16 (2025), DOI: 10.3389/fimmu.2025.1614610
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- Lucia Alianelli, Hossein Khosroabadi, John Sutter, Andrew C. Walters, Pierpaolo Romano, Kalotina Geraki, Francesco Carla, Jonathan Rawle, Sarah Barnett, Kawal Sawhney, "Characterization of cryo-cooled silicon crystal monochromators via measurement of flux versus power", Journal Of Synchrotron Radiation, 32 (2025), DOI: 10.1107/S160057752500342X
- Shabir Najmudin, Xiao-Su Pan, Beijia Wang, Lata Govada, Naomi E. Chayen, Noelia Rubio, Milo S. P. Shaffer, Henry S. Rzepa, L. Mark Fisher, Mark R. Sanderson, "Structural basis of topoisomerase targeting by delafloxacin", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-60688-3
- Nor Asyikin Che Husain, Azyyati Mohd Padzil, Azney Zuhaily Md. Taib, Nurulusna Che Zain, Mohd Faizal Abu Bakar, Kyle S. Gregory, K. Ravi Acharya, Mohd Anuar Jonet, Haryati Jamaluddin, "Biochemical and structural insights into GMHpaB: A thermostable 4-Hydroxyphenylacetate-3-monooxygenase with dual cofactor versatility", International Journal Of Biological Macromolecules, 19 (2025), DOI: 10.1016/j.ijbiomac.2025.146065
- Rebecca J. Parr, Yoann G. Santin, Giedrė Ratkevičiūte, Simon G. Caulton, Paul Radford, Dominik Gurvič, Matthew Jenkins, Matthew T. Doyle, Liam Mead, Augustinas Silale, Bert Van Den Berg, Timothy J. Knowles, R. Elizabeth Sockett, Phillip J. Stansfeld, Géraldine Laloux, Andrew L. Lovering, "A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-61633-0
- Emmanuel Matabaro, Haigang Song, Lukas Sonderegger, Fabio Gherlone, Andrew M. Giltrap, Sam Liver, Alvar D. Gossert, Markus Künzler, James H. Naismith, "Macrocyclization of backbone N-methylated peptides by a prolyl oligopeptidase with a distinctive substrate recognition mechanism", Chemical Science, 57 (2025), DOI: 10.1039/D5SC03723A
- Lindsay B. Tulloch, Hugh Tawell, Annie E. Taylor, Marta Lopes Lima, Alice Dawson, Sandra Carvalho, Richard J. Wall, Victoriano Corpas-Lopez, Gourav Dey, Jack Duggan, Luma Godoy Magalhaes, Leah S. Torrie, Laura Frame, David Robinson, Stephen Patterson, Michele Tinti, George W. Weaver, William J. Robinson, Monica Cal, Marcel Kaiser, Pascal Mäser, Peter Sjö, Benjamin Perry, John M. Kelly, Amanda Fortes Francisco, Avninder S. Bhambra, Susan Wyllie, "Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease", Science Translational Medicine, 17 (2025), DOI: 10.1126/scitranslmed.adu4564
- Madeline E. Kavanagh, Kirsty J. Mclean, Sophie H. Gilbert, Cecilia N. Amadi, Matthew Snee, Richard B. Tunnicliffe, Kriti Arora, Helena I. M. Boshoff, Alexander Fanourakis, Maria Jose Rebollo-Lopez, Fatima Ortega, Colin W. Levy, Andrew W. Munro, David Leys, Chris Abell, Anthony G. Coyne, "Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism", Journal Of Medicinal Chemistry (2025), DOI: 10.1021/acs.jmedchem.5c00478
- Yugeng Zhang, Marion Schuller, Ivan Ahel, Tim R. Blower, Rachel M. Exley, Christoph M. Tang, "Regulation of a phage defence island by RptR, a novel repressor that controls restriction–modification systems in diverse bacteria", Nucleic Acids Research, 53 (2025), DOI: 10.1093/nar/gkaf645
- Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya, "Ciprofloxacin inhibits Angiotensin I-Converting Enzyme (ACE) activity by binding at the exosite, distal to the catalytic pocket", Acs Bio & Med Chem Au, 5 (2025), DOI: 10.1021/acsbiomedchemau.5c00089
- Roman O. Fedoryshchak, Karim El-Bouri, Dhira Joshi, Stephane Mouilleron, Richard Treisman, "PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin", Elife, 13 (2025), DOI: 10.7554/eLife.103403
- [Thesis] Ashley E. Ramdass, "Structural mechanisms of multimeric BTB E3 ligases and interactors" (2025)
- Juho Alaviuhkola, Sondos Abdulmajeed, Sven T. Sowa, Johan Pääkkönen, Lari Lehtio, "Discovery of inhibitors for bacterial Arr enzymes ADP-ribosylating and inactivating rifamycin antibiotics", Acs Chemical Biology (2025), DOI: 10.1021/acschembio.5c00164
- Hugo Belda, David Bradley, Evangelos Christodoulou, Stephanie D. Nofal, Malgorzata Broncel, David Jones, Heledd Davies, M. Teresa Bertran, Andrew G. Purkiss, Roksana W. Ogrodowicz, Dhira Joshi, Nicola O’reilly, Louise Walport, Andrew Powell, David House, Svend Kjaer, Antoine Claessens, Christian R. Landry, Moritz Treeck, "The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound", Nature Microbiology, 10, 1463 - 1483 (2025), DOI: 10.1038/s41564-025-02017-4
- Katherine Mcphie, Diego Esposito, Jonathan Pettinger, Daniel Norman, Thilo Werner, Toby Mathieson, Jacob T. Bush, Katrin Rittinger, "Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination", Chemical Science, 28 (2025), DOI: 10.1039/D5SC01540E
- Pekka Kallunki, Florence Sotty, Katarina Willén, Michal Lubas, Laurent David, Malene Ambjørn, Ann-Louise Bergström, Louise Buur, Ibrahim Malik, Steffen Nyegaard, Thomas Thiilmark Eriksen, Berit O. Krogh, Jeffrey B. Stavenhagen, Kathrine J. Andersen, Lars Ø. Pedersen, Ersoy Cholak, Edward N. Van Den Brink, Rik Rademaker, Tom Vink, David Satijn, Paul W. H. I. Parren, Søren Christensen, Line R. Olsen, Josefine N. Søderberg, Sandra Vergo, Allan Jensen, Jan Egebjerg, Pernille Gry Wulff-Larsen, Mikkel N. Harndahl, Dina S. M. Damlund, Kaare Bjerregaard-Andersen, Karina Fog, "Rational selection of the monoclonal α-synuclein antibody amlenetug (Lu AF82422) for the treatment of α-synucleinopathies", Npj Parkinson'S Disease, 11 (2025), DOI: 10.1038/s41531-024-00849-1
- Wenjie Chen, "Fragment-based drug discovery for transthyretin kinetic stabilisers using a novel capillary zone electrophoresis method", Plos One, 20 (2025), DOI: 10.1371/journal.pone.0323816
- Mohammad Asadur Rahman, Subhadra Dalwani, Rajaram Venkatesan, "Structural enzymological studies of the long chain fatty acyl-CoA synthetase FadD5 from the mce1 operon of Mycobacterium tuberculosis", Biochemical And Biophysical Research Communications, 148 (2025), DOI: 10.1016/j.bbrc.2025.151960
- Syed Feroj Ahmed, Jayanthi Anand, Wei Zhang, Lori Buetow, Loveena Rishi, Louise Mitchell, Jonathan Bohlen, Sergio Lilla, Gary J. Sibbet, Colin Nixon, Amrita Patel, Karolina A. Majorek, Sara Zanivan, Jacinta C. Bustamante, Sachdev S. Sidhu, Karen Blyth, Danny T. Huang, "Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia", Molecular Therapy (2025), DOI: 10.1016/j.ymthe.2025.04.042
- [Thesis] Samuel P. Foster, "A combined methodology for radiation damage mitigation and enzyme intermediate study in macromolecular crystals" (2025), DOI: 10.25392/leicester.data.29155316.v1
- [Thesis] Beatrice De Bonis, "Repurposing human Carbonic Anhydrase 2 for artificial photosynthesis: structural and functional role of selected transition metals" (2025)
- Matthew J. Beech, Edmond C. Toma, Helen G. Smith, Maria M. Trush, Jit H. J. Ang, Mei Y. Wong, Chung H. J. Wong, Hafiz S. Ali, Zakia Butt, Viha Goel, Fernanda Duarte, Alistair J. M. Farley, Timothy R. Walsh, Christopher J. Schofield, "Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance", Chemical Science, 5 (2025), DOI: 10.1039/D5SC00964B
- Zihao Wang, Guodong Cao, Miranda P. Collier, Xingyu Qiu, Sophie Broadway-Stringer, Dominik Šaman, Jediael Z. Y. Ng, Navoneel Sen, Amar J. Azad, Charlotte Hooper, Johannes Zimmermann, Michael A. Mcdonough, Jurgen Brem, Patrick Rabe, Haigang Song, T. Reid Alderson, Christopher J. Schofield, Jani R. Bolla, Kristina Djinovic-Carugo, Dieter O. Fürst, Bettina Warscheid, Matteo T. Degiacomi, Timothy M. Allison, Georg K. A. Hochberg, Carol V. Robinson, Katja Gehmlich, Justin L. P. Benesch, "Filamin C dimerisation is regulated by HSPB7", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-58889-x
- Gara N. Dexter, Jason C. Grigg, Michael Zahn, Eloisa J. Wheatley, Jennifer Lian, William W. Mohn, Lindsay D. Eltis, "Characterization of a two-component kinase that initiates the bacterial catabolism of hydroxyphenylethanones", Journal Of Biological Chemistry, 9 (2025), DOI: 10.1016/j.jbc.2025.110210
- Jonathan J. Ford, Javier Santos-Aberturas, Edward S. Hems, Joseph W. Sallmen, Lena A. K. Bögeholz, Guy Polturak, Anne Osbourn, Joseph A. Wright, Marina V. Rodnina, Danny Vereecke, Isolde M. Francis, Andrew W. Truman, "Identification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target", Proceedings Of The National Academy Of Sciences, 122 (2025), DOI: 10.1073/pnas.2424388122
- [Conference Paper] Pierpaolo Romano, Hossein Khosroabadi, David Aragao, Ralf Flaig, "Microfocus and variable beam size at the Diamond Light Source I04 beamline" (2025), DOI: 10.1088/1742-6596/3010/1/012051
- [Conference Paper] Ralf Flaig, Pierpaolo Romano, David Aragao, "Dose aware data collection on the variable and microfocus macromolecular crystallography beamline I04 at Diamond Light Source" (2025), DOI: 10.1088/1742-6596/3010/1/012096
- Christian Roth, Olga V. Moroz, Suzan A. D. Miranda, Lucas Jahn, Elena V. Blagova, Andrey A. Lebedev, Dorotea R. Segura, Mary A. Stringer, Esben P. Friis, Joao P. L. Franco Cairo, Gideon J. Davies, Keith S. Wilson, "Structures of α-galactosaminidases from the CAZy GH114 family and homologs defining a new GH191 family of glycosidases", Acta Crystallographica Section D Structural Biology, 81 (2025), DOI: 10.1107/S2059798325002864
- Otsile O. Mojanaga, Timothy J. Woodman, Matthew D. Lloyd, K. Ravi Acharya, "Molecular basis of acyl-CoA ester recognition by α-methylacyl-CoA racemase from Mycobacterium tuberculosis", Journal Of Biological Chemistry, 275 (2025), DOI: 10.1016/j.jbc.2025.110302
- Ido Caspy, Shan Tang, Dom Bellini, Fabrice Gorrec, "A generic cross-seeding approach to protein crystallization", Journal Of Applied Crystallography, 58, 383 - 391 (2025), DOI: 10.1107/S1600576725000457
- Justin M. Bradley, Zinnia Bugg, Geoffrey R. Moore, Andrew m. Hemmings, Nick E. Le Brun, "Observation of the assembly of the nascent mineral core at the nucleation site of human mitochondrial ferritin", Journal Of The American Chemical Society (2025), DOI: 10.1021/jacs.5c01337
- Luisa Raucci, Cosimo Damiano Perrone, Stefano Barbera, Laurens Julius De Boer, Gian Marco Tosi, Jlenia Brunetti, Luisa Bracci, Cecilia Pozzi, Federico Galvagni, Maurizio Orlandini, "Structural and antigen-binding surface definition of an anti-CD93 monoclonal antibody for the treatment of degenerative vascular eye diseases", International Journal Of Biological Macromolecules, 77 (2025), DOI: 10.1016/j.ijbiomac.2025.143118
- William S. Stuart, Christopher H. Jenkins, Philip M. Ireland, Michail N. Isupov, Isobel H. Norville, Nicholas J. Harmer, "Structure and catalytic mechanism of methylisocitrate lyase, a potential drug target against Coxiella burnetii", Journal Of Biological Chemistry, 42 (2025), DOI: 10.1016/j.jbc.2025.108517
- Ane Martinez-Castillo, Diego Barriales, Mikel Azkargorta, Juan Diego Zalamea, Ana Ardá, Jesus Jimenez-Barbero, Monika Gonzalez-Lopez, Ana M. Aransay, Alejandro Marín-López, Erol Fikrig, Felix Elortza, Juan Anguita, Nicola G. A. Abrescia, "Structural and functional significance of Aedes aegypti AgBR1 flavivirus immunomodulator", Journal Of Virology (2025), DOI: 10.1128/jvi.01878-24
- Joanna Zukowska, Kyle S. Gregory, Adam Robinson, R. Elwyn Isaac, K. Ravi Acharya, "Molecular basis of dipeptide recognition in Drosophila melanogaster Angiotensin I-converting enzyme homologue, AnCE", Biomolecules, 15 (2025), DOI: 10.3390/biom15040591
- Edward W. Tate, Jasmine K. Bickel, Ammar. I. S. Ahmed, Aidan B. Pidd, Rhodri M. Morgan, Tom E. Mcallister, Sam M. Horrell, Emma C. Couves, Hemavathi Nagaraj, Edward J. Bartlett, Kamel El Omari, Akane Kawamura, Doryen Bubeck, "Macrocyclic peptide probes for immunomodulatory protein CD59: potent modulators of bacterial toxin activity and antibody-dependent cytotoxicity", Angewandte Chemie International Edition (2025), DOI: 10.1002/anie.202422673
- Pasquale A. Morese, Ayaz Ahmad, Mathewp. Martin, Richard A. Noble, Sara Pintar, Lan Z. Wang, Shangze Xu, Andrew Lister, Richard A. Ward, Agnieszka K. Bronowska, Martin E. M. Noble, Hannah L. Stewart, Michael J. Waring, "Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding", Communications Chemistry, 8 (2025), DOI: 10.1038/s42004-025-01501-6
- Camilla Gottlieb Andersen, Laust Bavnhøj, Søren Brag, Anastasiia Bohush, Adriana Chrenkova, Jan Heiner Driller, Bjorn Panyella Pedersen, "Comparative analysis of STP6 and STP10 unravels molecular selectivity in sugar transport proteins", Proceedings Of The National Academy Of Sciences, 122 (2025), DOI: 10.1073/pnas.2417370122
- Marco Paolino, Giusy Tassone, Paolo Governa, Mario Saletti, Matteo Lami, Riccardo Carletti, Filippo Sacchetta, Cecilia Pozzi, Maurizio Orlandini, Fabrizio Manetti, Massimo Olivucci, Andrea Cappelli, "Morita–Baylis–Hillman adduct chemistry as a tool for the design of lysine-targeted covalent ligands", Acs Medicinal Chemistry Letters, 16, 397 - 405 (2025), DOI: 10.1021/acsmedchemlett.4c00479
- Ben Ashley, Sam Mathew, Mariyah Sajjad, Yaoyi Zhu, Nikita Novikovs, Arnaud Basle, Jon Marles-Wright, Dominic J. Campopiano, "Rational engineering of a thermostable α-oxoamine synthase biocatalyst expands the substrate scope and synthetic applicability", Communications Chemistry, 8 (2025), DOI: 10.1038/s42004-025-01448-8
- Richard J. Suckling, Cevriye Pamukcu, Robert A. Simmons, Daniel Fonseca, Emma Grant, Rory Harrison, Saher A. Shaikh, Rahul C. Khanolkar, Hemza Ghadbane, Andrew Creese, Miriam Hock, Thomas G. Gligoris, Marco Lepore, Vijaykumar Karuppiah, Mariolina Salio, "Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor", Frontiers In Immunology, 16 (2025), DOI: 10.3389/fimmu.2025.1547664
- Virginie Will, Lucile Moynie, Elise Si Ahmed Charrier, Audrey Le Bas, Lauriane Kuhn, Florian Volck, Johana Chicher, Hava Aksoy, Morgan Madec, Cyril Antheaume, Gaëtan L. A. Mislin, Isabelle J. Schalk, "Structure of the outer membrane transporter fema and its role in the uptake of ferric dihydro-aeruginoic acid and ferric aeruginoic acid in Pseudomonas aeruginosa", Acs Chemical Biology (2025), DOI: 10.1021/acschembio.4c00820
- Alexandra Males, Olga V. Moroz, Elena Blagova, Astrid Munch, Gustav H. Hansen, Annette H. Johansen, Lars H. Østergaard, Dorotea R. Segura, Alexander Eddenden, Anne V. Due, Martin Gudmand, Jesper Salomon, Sebastian R. Sørensen, Joao Paulo L. Franco Cairo, Mark Nitz, Roland A. Pache, Rebecca M. Vejborg, Sandeep Bhosale, David J. Vocadlo, Gideon J. Davies, Keith S. Wilson, "Expansion of the diversity of dispersin scaffolds", Acta Crystallographica Section D Structural Biology, 81, 130 - 146 (2025), DOI: 10.1107/S205979832500110X
- Meng Wang, Prasanthi Medarametla, Thales Kronenberger, Tomas Deingruber, Paul Brear, Wendy Figueroa, Pok-Man Ho, Thomas Krueger, James C. Pearce, Antti Poso, James G. Wakefield, David R. Spring, Martin Welch, "Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-57532-z
- Inna Rozman Grinberg, Ornella Bimaï, Saher Shahid, Lena Philip, Markel Martinez-Carranza, Ipsita Banerjee, Daniel Lundin, Pal Stenmark, Britt-Marie Sjöberg, Derek T. Logan, "Bacterial transcriptional repressor NrdR - a flexible multifactorial nucleotide sensor", The Febs Journal (2025), DOI: 10.1111/febs.70037
- Mònica Torres Esteban, Matthew J. Stewart, Eilis Bragginton, Alice Meroni, Annica Pellizzari, Alain Jeanrenaud, Stephen J. Smerdon, Manuel Stucki, "MDC1 mediates Pellino recruitment to sites of DNA double-strand breaks", Life Science Alliance, 8 (2025), DOI: 10.26508/lsa.202403074
- Bine Simonsen, Henriette Rübsam, Marie Vogel Kolte, Maria Meisner Larsen, Christina Krönauer, Kira Gysel, Mette Laursen, Feng Feng, Gülendam Kaya, Giles E. D. Oldroyd, Jens Stougaard, Sébastien Fort, Simona Radutoiu, Kasper Røjkjær Andersen, "The Medicago truncatula LYR 4 intracellular domain serves as a scaffold in immunity signaling independent of its phosphorylation activity", New Phytologist, 118 (2025), DOI: 10.1111/nph.70067
- Geoffrey Masuyer, Alistair Taverner, Julia Mackay, Ana Rita Lima Marques, Yuye Wang, Tom Hunter, Keyi Liu, Randall J. Mrsny, "Discovery of mono-ADP ribosylating toxins with high structural homology to Pseudomonas exotoxin A", Communications Biology, 8 (2025), DOI: 10.1038/s42003-025-07845-y
- Simon C. C. Lucas, Yong Xu, Sarah Hewitt, Gavin W. Collie, Lucia Fusani, Ganesh Kadamur, Thomas E. Hadfield, Nancy Su, Caroline Truman, Sylvain Demanze, Haie Hao, Christopher Phillips, "Discovery of a series of covalent ligands that bind to Cys77 of the Von Hippel–Lindau Tumor Suppressor Protein (VHL)", Acs Medicinal Chemistry Letters (2025), DOI: 10.1021/acsmedchemlett.4c00582
- Larson Grimm, Andre Wijaya, Isabel Askenasy, Rahan Rudland Nazeer, Hikaru Seki, Paul D. Brear, Wendy Figueroa, David R. Spring, Martin Welch, "Pseudomonas aeruginosa PfpI is a methylglyoxalase", Journal Of Biological Chemistry, 2 (2025), DOI: 10.1016/j.jbc.2025.108374
- Linda Makhlouf, Mukul Mishra, Hannah Makhlouf, Iain Manfield, Luca Busino, Elton Zeqiraj, "Sequence rules for a long SPOP-binding degron required for protein ubiquitylation", Biochemical Journal (2025), DOI: 10.1042/BCJ20253041
- Kyle A. Barlow, Michael B. Battles, Michael E. Brown, Kaleigh Canfield, Xiaojun Lu, Heather Lynaugh, Morgan Morrill, C. Garrett Rappazzo, Saira P. Reyes, Chanita Sandberg, Beth Sharkey, Christin Strong, Jingfu Zhao, Arvind Sivasubramanian, "Design of orthogonal constant domain interfaces to aid proper heavy/light chain pairing of bispecific antibodies", Mabs, 17 (2025), DOI: 10.1080/19420862.2025.2479531
- Charles W. Parry, Francesca Pellicano, Alexander W. Schuettelkopf, Kim S. Beyer, Justin Bower, Amy Bryson, Kenneth Cameron, Nichole M. Cerutti, Jonathan P. Clark, Stuart C. Davidson, Keneth Davies, Martin J. Drysdale, Jeffrey Engelman, Anna Estevan-Barber, Andrea Gohlke, Christopher H. Gray, Daniel A. Guthy, Min Hong, Alana Hopkins, Luke D. Hutchinson, Jennifer Konczal, Michel Maira, Duncan Mcarthur, Mokdad Mezna, Heather Mckinnon, Ridvan Nepravishta, Nils Ostermann, Camila C. Pasquali, Katie Pollock, Angelo Pugliese, Nicholas Rooney, Niko Schmiedeberg, Paul Shaw, Camilo Velez-Vega, Christopher West, Ryan West, Frederic Zecri, John B. Taylor, "Reversible small molecule multivariant ras inhibitors display tunable affinity for the active and inactive forms of Ras", Journal Of Medicinal Chemistry, 49 (2025), DOI: 10.1021/acs.jmedchem.4c02929
- Thomas Powell, Vijaykumar Karuppiah, Saher Afshan Shaikh, Robert Pengelly, Nicole Mai, Keir Barnbrook, Amit Sharma, Stephen Harper, Martin Ebner, Andrew J. Creese, "Determining T-cell receptor binding orientation and Peptide-HLA interactions using cross-linking mass spectrometry", Journal Of Biological Chemistry, 20 (2025), DOI: 10.1016/j.jbc.2025.108445
- Juliane John, Daniel Lundin, Rui M. Branca, Rohit Kumar, Vivek Srinivas, Hugo Lebrette, Martin Högbom, "Characterization of a second class Ie ribonucleotide reductase", Communications Biology, 8 (2025), DOI: 10.1038/s42003-025-07565-3
- Mélanie Loiodice, Elodie Drula, Zak Mciver, Svetlana Antonyuk, Arnaud Basle, Marcelo Lima, Edwin A. Yates, Dominic P. Byrne, Jamie Coughlan, Andrew Leech, Shahram Mesdaghi, Daniel J. Rigden, Sophie Drouillard, William Helbert, Bernard Henrissat, Nicolas Terrapon, Gareth S. A. Wright, Marie Couturier, Alan Cartmell, "Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel", Proceedings Of The National Academy Of Sciences, 122 (2025), DOI: 10.1073/pnas.2421623122
- Rebecca L. Youle, María José Lista, Clement Bouton, Simone Kunzelmann, Harry Wilson, Matthew A. Cottee, Andrew G. Purkiss, Elizabeth R. Morris, Stuart J. D. Neil, Ian A. Taylor, Chad M. Swanson, "Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN", Journal Of Biological Chemistry, 297 (2025), DOI: 10.1016/j.jbc.2025.108336
- Anna M. Davies, David Trentham, Brian J. Sutton, Paul R. Brown, "Structure and activity of a phosphinothricin N-acetyltransferase (PSPTO_3321) from Pseudomonas syringae pv. tomato DC3000", Biochemical And Biophysical Research Communications, 6 (2025), DOI: 10.1016/j.bbrc.2025.151539
- Kevin M. Cottrell, Douglas A. Whittington, Kimberly J. Briggs, Haris Jahic, Janid A. Ali, Alvaro J. Amor, Deepali Gotur, Matthew R. Tonini, Wenhai Zhang, Alan Huang, John P. Maxwell, "MTA-cooperative PRMT5 inhibitors: mechanism switching through structure-based design", Journal Of Medicinal Chemistry, 68, 4217 - 4236 (2025), DOI: 10.1021/acs.jmedchem.4c01998
- Mahima Sharma, Nicholas Pudlo, Michael A. Järvå, Arashdeep Kaur, Alan John, Laura Burchill, James P. Lingford, Ruwan Epa, Palika Abayakoon, Nichollas E. Scott, Johan P. Turkenburg, Gideon J. Davies, Eric C. Martens, Ethan D. Goddard-Borger, Spencer J. Williams, "Sulfoglycolysis sustains Eubacterium rectale in low-fiber diets", Journal Of Biological Chemistry, 473 (2025), DOI: 10.1016/j.jbc.2025.108320
- Andreas Luttens, Duc Duy Vo, Emma R. Scaletti, Elisée Wiita, Ingrid Almlöf, Olov Wallner, Jonathan Davies, Sara Kosenina, Liuzhen Meng, Maeve Long, Oliver Mortusewicz, Geoffrey Masuyer, Flavio Ballante, Maurice Michel, Evert Homan, Martin Scobie, Christina Kalderén, Ulrika Warpman Berglund, Andrii V. Tarnovskiy, Dmytro S. Radchenko, Yurii S. Moroz, Jan Kihlberg, Pål Stenmark, Thomas Helleday, Jens Carlsson, "Virtual fragment screening for DNA repair inhibitors in vast chemical space", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-56893-9
- Joseph A Newman, Angeline E. Gavard, Nergis Imprachim, Hazel Aitkenhead, Hadley E. Sheppard, Robert Te Poele, Paul A. Clarke, Mohammad Anwar Hossain, Louisa Temme, Hans J. Oh, Carrow I. Wells, Zachary W. Davis-Gilbert, Paul Workman, Opher Gileadi, David H. Drewry, "Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-56213-1
- Josh Mcquail, Miroslav Krepl, Kai Katsuya-Gaviria, Aline Tabib-Salazar, Lynn Burchell, Thorsten Bischler, Tom Gräfenhan, Paul Brear, Jiří Šponer, Ben F. Luisi, Sivaramesh Wigneshweraraj, "Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability", Nucleic Acids Research, 53 (2025), DOI: 10.1093/nar/gkaf019
- Jason D. Shields, David Baker, Amber Y. S. Balazs, Gayathri Bommakanti, Robert Casella, Shenggen Cao, Steve Cook, Randolph A. Escobar, Stephen Fawell, Francis D. Gibbons, Kathryn A. Giblin, Frederick W. Goldberg, Eric Gosselin, Tyler Grebe, Niresh Hariparsad, Holia Hatoum-Mokdad, Rachel Howells, Samantha J. Hughes, Anne Jackson, Iswarya Karapa Reddy, Jason G. Kettle, Gillian M. Lamont, Scott Lamont, Min Li, Sten O. Nilsson Lill, Deanna A. Mele, Anthony J. Metrano, Adelphe M. Mfuh, Lucas A. Morrill, Bo Peng, Alexander Pflug, Theresa A. Proia, Hadi Rezaei, Ryan Richards, Magdalena Richter, Kevin J. Robbins, Maryann San Martin, Marianne Schimpl, Alwin G. Schuller, Li Sha, Minhui Shen, James E. Sheppeck, Meha Singh, Stephen Stokes, Kun Song, Yuanyuan Sun, Haoran Tang, David J. Wagner, Jianyan Wang, Yanjun Wang, David M. Wilson, Allan Wu, Chengyan Wu, Dedong Wu, Ye Wu, Kevin Xu, Yue Yang, Tieguang Yao, Minwei Ye, Andrew X. Zhang, Hui Zhang, Xiang Zhai, Yanxiao Zhou, Robert E. Ziegler, Neil P. Grimster, "Discovery and optimization of pyrazine carboxamide AZ3246, a selective HPK1 inhibitor", Journal Of Medicinal Chemistry (2025), DOI: 10.1021/acs.jmedchem.4c02631
- Alasdair D. Keith, Elizabeth B. Sawyer, Desmond C. Y. Choy, James L. Cole, Cheng Shang, George S. Biggs, Oskar J. Klein, Paul D. Brear, David J. Wales, Paul D. Barker, "Investigation into the effect of phenylalanine gating on anaerobic haem breakdown using the energy landscape approach", Protein Science, 34 (2025), DOI: 10.1002/pro.5243
- [Thesis] Monse Manzo Ruiz, "Structural enzymology of spirotetronate cyclases" (2025)
- Kyle S. Gregory, Gyles E. Cozier, Stephen Fienberg, Kelly Chibale, Edward D. Sturrock, K. Ravi Acharya, "Molecular basis of human angiotensin‐1 converting enzyme inhibition by a series of diprolyl‐derived compounds", The Febs Journal, 389 (2025), DOI: 10.1111/febs.17384
- Rohan Eapen, Cynthia Okoye, Christopher Stubbs, Marianne Schimpl, Thomas Tischer, Eileen Mccall, Maria Zacharopoulou, Fernando Ferrer, David Barford, David Spring, Cath Lindon, Christopher Phillips, Laura S. Itzhaki, "Development of D-box peptides to inhibit the anaphase promoting complex/cyclosome", Elife (2025), DOI: 10.7554/eLife.104238
- [Thesis] Keir Whiting, "Investigating the consequences of substituting histidine ligands to hemes in the decaheme cytochrome MtrC" (2025)
- Christopher P. Earl, Mathias Cobbaut, André Barros-Carvalho, Marina E. Ivanova, David C. Briggs, Eurico Morais-De-Sá, Peter J. Parker, Neil Q. Mcdonald, "Capture, mutual inhibition and release mechanism for aPKC–Par6 and its multisite polarity substrate Lgl", Nature Structural & Molecular Biology, 23 (2025), DOI: 10.1038/s41594-024-01425-0
- Rokas Petrenas, Olivia A. Hawkins, Jacob F. Jones, D. Arne Scott, Jordan Fletcher, Ulrike Obst, Lucia Lombardi, Fabio Pirro, Graham J. Leggett, Thomas A. A. Oliver, Derek N. Woolfson, "Confinement and catalysis within de novo designed peptide barrels", Journal Of The American Chemical Society (2025), DOI: 10.1021/jacs.4c16633
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