Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
25 items found for 2009 [total: 2283]
Structural characterisation of ligand-binding determinants in human lung surfactant protein D: influence of Asp325 Journal Of Molecular Biology, 394 (4) Dec 2009 DOI: 10.1016/j.jmb.2009.09.057
Structure of an Escherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 Å resolution Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65 (11) Nov 2009 DOI: 10.1107/S1744309109037403
Journal Paper I04-Macromolecular Crystallography
An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 Kinase is released through binding of Nek9 Molecular Cell, 36 (4) Nov 2009 DOI: 10.1016/j.molcel.2009.09.038
Structural basis for substrate recognition in the enzymatic component of ADP-ribosyltransferase toxin CDTa from Clostridium difficile Journal Of Biological Chemistry, 284 Oct 2009 DOI: 10.1074/jbc.M109.043018
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage Cell, 139 (1) Oct 2009 DOI: 10.1016/j.cell.2009.07.043
Journal Paper I04-Macromolecular Crystallography
Role of the polycomb protein Eed in the propagation of repressive histone marks Nature, 461 Oct 2009 DOI: 10.1038/nature08398
Journal Paper I04-Macromolecular Crystallography
Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide Angewandte Chemie International Edition, 48 (48) Oct 2009 DOI: 10.1002/anie.200903407
Journal Paper I04-Macromolecular Crystallography
Crystal structures of α-crystallin domain dimers of αB-crystallin and Hsp20 Journal Of Molecular Biology, 392 (5) Oct 2009 DOI: 10.1016/j.jmb.2009.07.069
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor Science, 325 Sept 2009 DOI: 10.1126/science.1174468
The prolyl oligopeptidae family enzymes: structural basis of inhibition Sept 2009
Thesis I04-Macromolecular Crystallography
HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives Bioorganic & Medicinal Chemistry Letters, 19(15) Aug 2009 DOI: 10.1016/j.bmcl.2009.05.022
Journal Paper I04-Macromolecular Crystallography
Structural basis for functional tetramerization of lentiviral integrase Plos Pathogens, 5(7) Jul 2009 DOI: 10.1371/journal.ppat.1000515
Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release Biochemistry, 48 (23) June 2009 DOI: 10.1021/bi802335s
Crystal structures of Cif from bacterial pathogens Photorhabdus luminescens and Burkholderia pseudomallei Plos One, May 2009 DOI: 10.1371/journal.pone.0005582
Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases Journal Of Medicinal Chemistry, 52 (9) May 2009 DOI: 10.1021/jm800963t
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65 May 2009 DOI: 10.1107/S1744309109012007
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases Nature Structural & Molecular Biology, 16 (6) May 2009 DOI: 10.1038/nsmb.1604
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure Chembiochem, 10 (8) May 2009 DOI: 10.1002/cbic.200900071
Journal Paper I04-Macromolecular Crystallography
Crystal structure of the human tRNAGly microhelix isoacceptor G9990 at 1.18A resolution Biochemical And Biophysical Research Communications, 380 Mar 2009 DOI: 10.1016/j.bbrc.2009.01.127
Journal Paper I04-Macromolecular Crystallography
Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity Journal Of Molecular Biology, 387(1) Mar 2009 DOI: 10.1016/j.jmb.2008.12.086
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structures of Leishmania major orthologues of macrophage migration inhibitory factor Biochemical And Biophysical Research Communications, 380 (3) Mar 2009 DOI: 10.1016/j.bbrc.2009.01.030
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS Proceedings Of The National Academy Of Sciences, 106 (5) Feb 2009 DOI: 10.1073/pnas.0809020106
The crystal structure of an avian IgY-Fc fragment reveals conservation with both mammalian IgG and IgE Biochemistry, 48 (3) Jan 2009 DOI: 10.1021/bi8019993
Journal Paper I04-Macromolecular Crystallography
Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK Nucleic Acids Research, 37 (5) Jan 2009 DOI: 10.1093/nar/gkn1086
Overexpression, purification and preliminary X-ray diffraction analysis of the controller protein C.Csp231I from Citrobacter sp RFL231 Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65 Jan 2009 DOI: 10.1107/S1744309109028681
- A. K. Shrive, C. Martin, I. Burns, J. M. Paterson, J. D. Martin, J. P. Townsend, P. Waters, H. W. Clark, U. Kishore, K. B. M. Reid, T. J. Greenhough, "Structural characterisation of ligand-binding determinants in human lung surfactant protein D: influence of Asp325", Journal Of Molecular Biology, 394 (4), 776-788 (2009), DOI: 10.1016/j.jmb.2009.09.057
- Ivan Campeotto, Adam S. Nelson, Simon E. V. Phillips, Arwen Pearson, Stephen Carr, Chi Hung Trinh, "Structure of an Escherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 Å resolution", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65 (11), 1088-1090 (2009), DOI: 10.1107/S1744309109037403
- Mark W. Richards, Laura O'Regan, Corine Mas-Droux, Joelle M. Y. Blot, Jack Cheung, Swen Hoelder, Andrew M. Fry, Richard Bayliss, "An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 Kinase is released through binding of Nek9", Molecular Cell, 36 (4), 560-570 (2009), DOI: 10.1016/j.molcel.2009.09.038
- Amit Sundriyal, April K. Roberts, Clifford C. Shone, K. Ravi Acharya, "Structural basis for substrate recognition in the enzymatic component of ADP-ribosyltransferase toxin CDTa from Clostridium difficile", Journal Of Biological Chemistry, 284, 28713-28719. (2009), DOI: 10.1074/jbc.M109.043018
- Janette Lloyd, J. Ross Chapman, Julie A. Clapperton, Lesley F. Haire, Edgar Hartsuiker, Jiejin Li, Antony M. Carr, Stephen P. Jackson, Stephen J. Smerdon, "A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage", Cell, 139 (1), 100 - 111 (2009), DOI: 10.1016/j.cell.2009.07.043
- Raphael Margueron, Neil Justin, Katsuhito Ohno, Miriam Sharpe, Jinsook Son, William J. Drury Iii, Philipp Voigt, Stephen Martin, William Taylor, Valeria De Marco, Vincenzo Pirotta, Danny Reinberg, Steven Gamblin, "Role of the polycomb protein Eed in the propagation of repressive histone marks", Nature, 461, 762-767 (2009), DOI: 10.1038/nature08398
- Paul Fyfe, Vincent Rao, Aleksandra Zemla, Scott Cameron, William Hunter, "Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide", Angewandte Chemie International Edition, 48 (48), 9176-9179 (2009), DOI: 10.1002/anie.200903407
- C. Bagnéris, O. A. Bateman, C. E. Naylor, N. Cronin, W. C. Boelens, N. H. Keep, C. Slingsby, "Crystal structures of α-crystallin domain dimers of αB-crystallin and Hsp20", Journal Of Molecular Biology, 392 (5), 1242 - 1252 (2009), DOI: 10.1016/j.jmb.2009.07.069
- Jingjie Yang, Ziguo Zhang, Mark Roe, Christopher J. Marshall, David Barford, "Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor", Science, 325 (2009), DOI: 10.1126/science.1174468
- [Thesis] Peter Canning, "The prolyl oligopeptidae family enzymes: structural basis of inhibition" (2009)
- Guangyi Wang, Huoxing Lei, Xiaofang Wang, Debasis Das, Jian Hong, Colin Mackinnon, Thomas Coulter, Christian A. G. N. Montalbetti, Richard Mears, Xinjie Gai, Sarah E. Bailey, Donald Ruhrmund, Lisa Hooi, Shawn Misialek, P. T. Ravi Rajagopalan, Robert K. Y. Cheng, John Barker, Brunella Felicetti, Dorian L. Schönfeld, Antitsa Stoycheva, "HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives", Bioorganic & Medicinal Chemistry Letters, 19(15), 4480-3 (2009), DOI: 10.1016/j.bmcl.2009.05.022
- Stephen Hare, Francesca Di Nunzio, Alfred Labeja, Jimin Wang, Alan Engelmann, Peter Cherepanov, "Structural basis for functional tetramerization of lentiviral integrase", Plos Pathogens, 5(7) (2009), DOI: 10.1371/journal.ppat.1000515
- Olga Mayans, Miriam Deuss, Marc Bruning, Andreas Ivens, Thomas Schwab, Nadja Hellmann, Reinhard Sterner, "Activation of anthranilate phosphoribosyltransferase from Sulfolobus solfataricus by removal of magnesium inhibition and acceleration of product release", Biochemistry, 48 (23), 5199 - 5209 (2009), DOI: 10.1021/bi802335s
- G. Jubelin, Carolina Varela Chavez, Jean-Michel Escoubas, Eric Oswald, Mark J. Banfield, Allister Crow, Paul R. Race, "Crystal structures of Cif from bacterial pathogens Photorhabdus luminescens and Burkholderia pseudomallei", Plos One (2009), DOI: 10.1371/journal.pone.0005582
- Matthew Davies, Timo Heikkila, Glenn A. Mcconkey, Colin W. G. Fishwick, Mark R. Parsons, A. Peter Johnson, "Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases", Journal Of Medicinal Chemistry, 52 (9), 2683 - 2693 (2009), DOI: 10.1021/jm800963t
- Arwen R. Pearson, Simon E. V. Phillips, Michael J. Mcpherson, Didem Sutay Kocabas, Ufuk Bakir, Zumrut B. Ogel, Chi H. Trinh, "Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65, 486-488 (2009), DOI: 10.1107/S1744309109012007
- Ivan Laponogov, Maninder K Sohi, Dennis A Veselkov, Xiao-Su Pan, Ritica Sawhney, Andrew W. Thompson, Katherine Mcauley, L. Mark Fisher, Mark R. Sanderson, "Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases", Nature Structural & Molecular Biology, 16 (6), 667 - 669 (2009), DOI: 10.1038/nsmb.1604
- Christopher R. Pudney, Tom Mcgrory, Pierre Lafite, Jiayun Pang, Sam Hay, David Leys, Michael J. Sutcliffe, Nigel S. Scrutton, "Parallel pathways and free-energy landscapes for enzymatic hydride transfer probed by hydrostatic pressure", Chembiochem, 10 (8), 1379 - 1384 (2009), DOI: 10.1002/cbic.200900071
- A. Eichert, M. Perbandt , A. Schreiber, J. P. Fürste, C. Betzel, V. A. Erdmann, C. Förster, "Crystal structure of the human tRNAGly microhelix isoacceptor G9990 at 1.18A resolution", Biochemical And Biophysical Research Communications, 380, 503 - 507 (2009), DOI: 10.1016/j.bbrc.2009.01.127
- Cecile M. Tron, Iain W. Mcnae, Margeret Nutley, David J. Clarke, Alan Cooper, Malcolm D. Walkinshaw, Robert L. Baxter, Dominic J. Campopiano, "Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity", Journal Of Molecular Biology, 387(1), 129-46 (2009), DOI: 10.1016/j.jmb.2008.12.086
- Julia Richardson, Lesley S. Morrison, Nicholas D. Bland, Sandra Bruce, Graham H. Coombs, Jeremy C. Mottram, Malcolm D. Walkinshaw, "Structures of Leishmania major orthologues of macrophage migration inhibitory factor", Biochemical And Biophysical Research Communications, 380 (3), 442 - 448 (2009), DOI: 10.1016/j.bbrc.2009.01.030
- Duo Lu, Mirka E. Wormann, Xiaodong Zhang, Olaf Schneewind , Angelika Grundling, Paul S. Freemont, "Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS", Proceedings Of The National Academy Of Sciences, 106 (5), 1584-9 (2009), DOI: 10.1073/pnas.0809020106
- Alexander I. Taylor, Stella M. Fabiane, Rosaleen A. Calvert, Brian J. Sutton, "The crystal structure of an avian IgY-Fc fragment reveals conservation with both mammalian IgG and IgE", Biochemistry, 48 (3), 558 - 562 (2009), DOI: 10.1021/bi8019993
- A. A. Ali, R. M. Jukes, L. Pearl, A. W. Oliver, "Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK", Nucleic Acids Research, 37 (5), 1701-1712 (2009), DOI: 10.1093/nar/gkn1086
- S. D. Streeter, J. E. Mcgeehan, G. G. Kneale, "Overexpression, purification and preliminary X-ray diffraction analysis of the controller protein C.Csp231I from Citrobacter sp RFL231", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 65, 898-901 (2009), DOI: 10.1107/S1744309109028681
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