Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
161 items found for 2018 [total: 2283]
Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1 Nature Communications, 9 Dec 2018 DOI: 10.1038/s41467-018-07794-7
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry Biochemical Journal, Dec 2018 DOI: 10.1042/BCJ20180788
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease Elife, 7 Dec 2018 DOI: 10.7554/eLife.39865
qFit-ligand reveals widespread conformational heterogeneity of drug-like molecules in X-ray electron density maps Journal Of Medicinal Chemistry, Dec 2018 DOI: 10.1021/acs.jmedchem.8b01292
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Druggability simulations and X-ray crystallography reveal a ligand-binding site in the Glua3 Ampa receptor N-terminal domain Structure, Dec 2018 DOI: 10.1016/j.str.2018.10.017
Journal Paper I04-Macromolecular Crystallography
Structural basis for the specificity of renin-mediated angiotensinogen cleavage Journal Of Biological Chemistry, Dec 2018 DOI: 10.1074/jbc.RA118.006608
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
DNA translocation mechanism of an XPD family helicase Elife, 7 Dec 2018 DOI: 10.7554/eLife.42400
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Characterization of a putrescine transaminase from pseudomonas putida and its application to the synthesis of benzylamine derivatives Frontiers In Bioengineering And Biotechnology, Dec 2018 DOI: 10.3389/fbioe.2018.00205
Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design Cell, 175 Nov 2018 DOI: 10.1016/j.cell.2018.10.037
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation Nature Microbiology, 130 Nov 2018 DOI: 10.1038/s41564-018-0271-y
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
A structural and synthetic biology study of bacterial microcompartments Nov 2018
Thesis I02-Macromolecular Crystallography I04-Macromolecular Crystallography
A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL) Journal Of Medicinal Chemistry, Nov 2018 DOI: 10.1021/acs.jmedchem.8b01457
Journal Paper I04-Macromolecular Crystallography
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor Bioorganic & Medicinal Chemistry Letters, Nov 2018 DOI: 10.1016/j.bmcl.2018.11.009
Journal Paper I04-Macromolecular Crystallography
Structural insights into the function of type VI secretion system TssA subunits Nature Communications, 9 Nov 2018 DOI: 10.1038/s41467-018-07247-1
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure and reactivity of a siderophore-interacting protein from the marine bacterium Shewanella reveals unanticipated functional versatility Journal Of Biological Chemistry, Nov 2018 DOI: 10.1074/jbc.RA118.005041
Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases The Febs Journal, Nov 2018 DOI: 10.1111/febs.14695
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation Science, 362 Nov 2018 DOI: 10.1126/science.aar8048
Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease Bioorganic & Medicinal Chemistry Letters, 28 Nov 2018 DOI: 10.1016/j.bmcl.2018.09.022
Journal Paper I04-Macromolecular Crystallography
Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition Cell Chemical Biology, Nov 2018 DOI: 10.1016/j.chembiol.2018.10.015
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase Nature Structural & Molecular Biology, 434 Nov 2018 DOI: 10.1038/s41594-018-0152-3
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Computational design of symmetrical eight-bladed β-propeller proteins Iucrj, 6 Nov 2018 DOI: 10.1107/S205225251801480X
(ADP-ribosyl)hydrolases: structural basis for differential substrate recognition and inhibition Cell Chemical Biology, Nov 2018 DOI: 10.1016/j.chembiol.2018.11.001
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Cell-active small molecule inhibitors of the DNA-damage repair enzyme poly(ADP-ribose) glycohydrolase (PARG): Discovery and optimization of orally bioavailable quinazolinedione sulfonamides Journal Of Medicinal Chemistry, Nov 2018 DOI: 10.1021/acs.jmedchem.8b01407
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
From 1,4-disaccharide to 1,3-glycosyl carbasugar: Synthesis of a bespoke inhibitor of family GH99 endo-α-mannosidase Organic Letters, Nov 2018 DOI: 10.1021/acs.orglett.8b03260
Identification of fragments binding to CHD1 double chromodomain, an epigenetic reader of KDM1A K114me2 and H3 K4me3 Nov 2018
Thesis I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Structural characterisation of calnexin cycle components and assessment as antiviral targets Nov 2018
Thesis I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
SAR studies leading to the identification of a novel series of metallo-β-lactamase inhibitors for the treatment of carbapenem-resistant Enterobacteriaceae infections that display efficacy in an animal infection model Acs Infectious Diseases, Nov 2018 DOI: 10.1021/acsinfecdis.8b00246
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
New irreversible α- l -Iduronidase inhibitors and activity-based probes Chemistry - A European Journal, 42 Nov 2018 DOI: 10.1002/chem.201804662
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens Hypoxia, Volume 6 Nov 2018 DOI: 10.2147/HP.S174655
Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly Iucrj, 5 Nov 2018 DOI: 10.1107/S2052252518012459
Maintaining and breaking symmetry in homomeric coiled-coil assemblies Nature Communications, 9 Oct 2018 DOI: 10.1038/s41467-018-06391-y
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Pathological macromolecular crystallographic data affected by twinning, partial-disorder and exhibiting multiple lattices for testing of data processing and refinement tools Scientific Reports, 8 Oct 2018 DOI: 10.1038/s41598-018-32962-6
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
The molecular basis of protein toxin HicA–dependent binding of the protein antitoxin HicB to DNA Journal Of Biological Chemistry, Oct 2018 DOI: 10.1074/jbc.RA118.005173
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Non-equivalence of second sphere ‘non-catalytic’ residues in pentaerythritol tetranitrate reductase in relation to local dynamics linked to H-transfer in reactions with NADH and NADPH coenzymes Acs Catalysis, Oct 2018 DOI: 10.1021/acscatal.8b02810
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Potent antimalarial 2-pyrazoyl quinolone bc1 (Qi) inhibitors with improved drug-like properties Acs Medicinal Chemistry Letters, Oct 2018 DOI: 10.1021/acsmedchemlett.8b00371
Journal Paper I04-Macromolecular Crystallography
The dimeric structure of wild-type human glycosyltransferase B4GalT1 Plos One, 13 Oct 2018 DOI: 10.1371/journal.pone.0205571
New thermophilic α/β class epoxide hydrolases found in metagenomes from hot environments Frontiers In Bioengineering And Biotechnology, 6 Oct 2018 DOI: 10.3389/fbioe.2018.00144
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural basis for DNA break recognition by ARTD2/PARP2 Nucleic Acids Research, 7 Oct 2018 DOI: 10.1093/nar/gky927
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors Chemical Science, 434 Oct 2018 DOI: 10.1039/C8SC03831G
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis Nature, 441 Oct 2018 DOI: 10.1038/s41586-018-0644-7
Co-crystallization of human inositol monophosphatase with the lithium mimetic L-690,330 Acta Crystallographica Section D Structural Biology, 74 Oct 2018 DOI: 10.1107/S2059798318010380
BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands Elife, 7 Oct 2018 DOI: 10.7554/eLife.39979
Structure and function of a glycoside hydrolase family 8 endoxylanase from Teredinibacter turnerae Acta Crystallographica Section D Structural Biology, 74 Oct 2018 DOI: 10.1107/S2059798318009737
Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors Elife, 7 Oct 2018 DOI: 10.7554/eLife.38362
Structure-based classification defines the discrete conformational classes adopted by the arenaviral GP1 Journal Of Virology, Oct 2018 DOI: 10.1128/JVI.01048-18
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I23-Long wavelength MX open access
Type II kinase inhibitors targeting Cys-gatekeeper kinases display orthogonality with wild type and Ala/Gly-gatekeeper kinases Acs Chemical Biology, Sept 2018 DOI: 10.1021/acschembio.8b00592
Journal Paper I04-Macromolecular Crystallography
Crystal structure and functional analysis of human C1ORF123 Peerj, 6 Sept 2018 DOI: 10.7717/peerj.5377
The quaternary structure of Thermus thermophilus aldehyde dehydrogenase is stabilized by an evolutionary distinct C-terminal arm extension Scientific Reports, 8 Sept 2018 DOI: 10.1038/s41598-018-31724-8
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
TssA from Burkholderia cenocepacia : expression, purification, crystallization and crystallographic analysis Acta Crystallographica Section F Structural Biology Communications, 74 Sept 2018 DOI: 10.1107/S2053230X18009706
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Unraveling substrate specificity and catalytic promiscuity of Aspergillus oryzae catechol oxidase Chembiochem, Sept 2018 DOI: 10.1002/cbic.201800387
Journal Paper I04-Macromolecular Crystallography
A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1 Nucleic Acids Research, 5 Sept 2018 DOI: 10.1093/nar/gky863
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural cycle of the Thermus thermophilus PilF ATPase: the powering of type IVa pilus assembly Scientific Reports, 8 Sept 2018 DOI: 10.1038/s41598-018-32218-3
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography Krios I-Titan Krios I at Diamond open access
The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs Plos One, 13 Sept 2018 DOI: 10.1371/journal.pone.0203532
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, Sept 2018 DOI: 10.1016/j.bbapap.2018.09.005
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel Journal Of Biological Chemistry, Sept 2018 DOI: 10.1074/jbc.RA118.003857
TssA from Aeromonas hydrophila : expression, purification and crystallographic studies Acta Crystallographica Section F Structural Biology Communications, 74 Sept 2018 DOI: 10.1107/S2053230X18010439
Substrate recognition and autoinhibition in the central ribonuclease RNase E Molecular Cell, Sept 2018 DOI: 10.1016/j.molcel.2018.08.039
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB Mbio, 9 Sept 2018 DOI: 10.1128/mBio.01346-18
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Manipulating the folding landscape of a multidomain protein The Journal Of Physical Chemistry B, 122 Sept 2018 DOI: 10.1021/acs.jpcb.8b04834
Journal Paper I04-Macromolecular Crystallography
Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding Nature Communications, 9 Aug 2018 DOI: 10.1038/s41467-018-05459-z
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt co-receptor LRP6 Febs Letters, Aug 2018 DOI: 10.1002/1873-3468.13212
Novel quinazolinone inhibitors of ALK2 flip between alternate binding modes: Structure–activity relationship, structural characterization, kinase profiling, and cellular proof of concept Journal Of Medicinal Chemistry, Aug 2018 DOI: 10.1021/acs.jmedchem.8b00782
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Redox-switchable siderophore anchor enables reversible artificial metalloenzyme assembly Nature Catalysis, 308 Aug 2018 DOI: 10.1038/s41929-018-0124-3
Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration Mabs, 5 Aug 2018 DOI: 10.1080/19420862.2018.1505464
A fluorescent robe identifies active site ligands of inositol pentakisphosphate 2-kinase Journal Of Medicinal Chemistry, Aug 2018 DOI: 10.1021/acs.jmedchem.8b01022
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies Bioorganic & Medicinal Chemistry, Aug 2018 DOI: 10.1016/j.bmc.2018.08.014
Journal Paper I04-Macromolecular Crystallography
Evolutionary analysis is a powerful complement to energy calculations for protein stabilization Acs Catalysis, Aug 2018 DOI: 10.1021/acscatal.8b01677
Journal Paper I04-Macromolecular Crystallography
Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody Scientific Reports, 8 Aug 2018 DOI: 10.1038/s41598-018-29664-4
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Arabidopsis downy mildew effector HaRxL106 suppresses plant immunity by binding to RADICAL-INDUCED CELL DEATH1 New Phytologist, 220 Aug 2018 DOI: 10.1111/nph.15277
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release Science Signaling, 11 Aug 2018 DOI: 10.1126/scisignal.aao2464
Journal Paper I04-Macromolecular Crystallography
Phosphoglycerate kinase and phosphoenolpyruvate synthase of the enteric pathogen Helicobacter pylori Aug 2018
Thesis I04-Macromolecular Crystallography open access
Studying the mechanism and action of Purine biosynthesis enzymes in Mycobacterium Tuberculosis H37RV Aug 2018
Thesis I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders Jbic Journal Of Biological Inorganic Chemistry, 84 Aug 2018 DOI: 10.1007/s00775-018-1605-1
Journal Paper I04-Macromolecular Crystallography
An aspartate-specific solute-binding protein regulates protein kinase G activity to control glutamate metabolism in mycobacteria Mbio, 9 Jul 2018 DOI: 10.1128/mBio.00931-18
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling The Embo Journal, Jul 2018 DOI: 10.15252/embj.201899372
Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset Proceedings Of The National Academy Of Sciences, 47 Jul 2018 DOI: 10.1073/pnas.1607817115
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure–function analyses of the bacterial zinc metalloprotease effector protein GtgA uncovers key residues required for deactivating NF-κB Journal Of Biological Chemistry, Jul 2018 DOI: 10.1074/jbc.RA118.004255
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
van der Waals contact between nucleophile and transferring phosphorus is insufficient to achieve enzyme transition state architecture Acs Catalysis, Jul 2018 DOI: 10.1021/acscatal.8b01612
Stereo- and regioselectivity in catalyzed transformation of a 1,2-disubstituted vicinal diol and the corresponding diketone by wild type and laboratory evolved alcohol dehydrogenases Acs Catalysis, Jul 2018 DOI: 10.1021/acscatal.8b01762
Polymorphic residues in rice NLRs expand binding and response to effectors of the blast pathogen Nature Plants, 354 Jul 2018 DOI: 10.1038/s41477-018-0194-x
Chlamydia protein Pgp3 studied at high resolution in a new crystal form Iucrj, 5 Jul 2018 DOI: 10.1107/S2052252518007637
Identification of a tyrosine switch in copper-haem nitrite reductases Iucrj, 5 Jul 2018 DOI: 10.1107/S2052252518008242
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase Nature Communications, 9 Jul 2018 DOI: 10.1038/s41467-018-05005-x
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural characterisation of oligosaccharide recognition by surfactant protein D Jul 2018
Thesis I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
SIMBAD : a sequence-independent molecular-replacement pipeline Acta Crystallographica Section D Structural Biology, 74 Jul 2018 DOI: 10.1107/S2059798318005752
Ycf48 involved in the biogenesis of the oxygen-evolving photosystem II complex is a seven-bladed beta-propeller protein Proceedings Of The National Academy Of Sciences, 49 Jul 2018 DOI: 10.1073/pnas.1800609115
Reactivity and selectivity of iminium organocatalysis improved by a protein host Angewandte Chemie International Edition, Jul 2018 DOI: 10.1002/anie.201806850
Novel insights into the degradation of β-1,3-glucans by the cellulosome of Clostridium thermocellum revealed by structure and function studies of a family 81 glycoside hydrolase International Journal Of Biological Macromolecules, June 2018 DOI: 10.1016/j.ijbiomac.2018.06.003
Journal Paper I04-Macromolecular Crystallography
An aminocaprolactam racemase from ochrobactrum anthropi with promiscuous amino acid ester racemase activity Chembiochem, June 2018 DOI: 10.1002/cbic.201800265
Journal Paper I04-Macromolecular Crystallography
Unravelling the relaxed specificity of laminaribiose phosphorylase from Paenibacillus sp. strain YM-1 towards mannose 1-phosphate Chembiochem, June 2018 DOI: 10.1002/cbic.201800260
Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and Ribonuclease P complexes Journal Of Biological Chemistry, June 2018 DOI: 10.1074/jbc.RA117.001286
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation Journal Of The American Chemical Society, June 2018 DOI: 10.1021/jacs.8b05807
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
A mechanism for the activation of the influenza virus transcriptase Molecular Cell, June 2018 DOI: 10.1016/j.molcel.2018.05.011
Discovery of potent, selective and peripherally restricted pan-Trk kinase inhibitors for the treatment of pain Journal Of Medicinal Chemistry, June 2018 DOI: 10.1021/acs.jmedchem.8b00633
Journal Paper I04-Macromolecular Crystallography
A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion Nature Communications, 9 June 2018 DOI: 10.1038/s41467-018-04878-2
The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases Nature Chemical Biology, 14 June 2018 DOI: 10.1038/s41589-018-0071-y
Journal Paper I04-Macromolecular Crystallography
Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14 Bioorganic & Medicinal Chemistry Letters, May 2018 DOI: 10.1016/j.bmcl.2018.04.056
Journal Paper I04-Macromolecular Crystallography
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines European Journal Of Medicinal Chemistry, 152 May 2018 DOI: 10.1016/j.ejmech.2018.04.035
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Redox regulated methionine oxidation of Arabidopsis thaliana glutathione transferase Phi9 induces H-site flexibility Protein Science, May 2018 DOI: 10.1002/pro.3440
Journal Paper I04-Macromolecular Crystallography
Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif Acta Crystallographica Section D Structural Biology, 74 May 2018 DOI: 10.1107/S2059798318002942
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Hydrogel composite membranes incorporating iron oxide nanoparticles as topographical designers for controlled heteronucleation of proteins Crystal Growth & Design, May 2018 DOI: 10.1021/acs.cgd.7b01760
Journal Paper I04-Macromolecular Crystallography
Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype Plos One, 13 May 2018 DOI: 10.1371/journal.pone.0196761
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structural basis of actin monomer re-charging by cyclase-associated protein Nature Communications, 9 May 2018 DOI: 10.1038/s41467-018-04231-7
Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig Plos Pathogens, 14 May 2018 DOI: 10.1371/journal.ppat.1007017
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Insights into substrate specificity of archaeal Entner-Doudoroff aldolases Biochemistry, May 2018 DOI: 10.1021/acs.biochem.8b00535
Journal Paper I04-Macromolecular Crystallography
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition Nature Communications, 9 May 2018 DOI: 10.1038/s41467-018-04214-8
Structural and functional determination of homologs of the Mycobacterium tuberculosis N -acetylglucosamine-6-phosphate deacetylase (NagA) Journal Of Biological Chemistry, May 2018 DOI: 10.1074/jbc.RA118.002597
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Disease-associated mutations in CEP120 destabilize the protein and impair ciliogenesis Cell Reports, 23 May 2018 DOI: 10.1016/j.celrep.2018.04.100
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure and biocatalytic scope of coclaurine N-methyltransferase Angewandte Chemie International Edition, May 2018 DOI: 10.1002/anie.201805060
Structures of ebolavirus glycoprotein complexes with tricyclic antidepressant and antipsychotic drugs Journal Of Medicinal Chemistry, May 2018 DOI: 10.1021/acs.jmedchem.8b00350
New imine-reducing enzymes from β-hydroxyacid dehydrogenases by single amino acid substitutions Protein Engineering, Design And Selection, 9 May 2018 DOI: 10.1093/protein/gzy006
Journal Paper I04-Macromolecular Crystallography
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus Nature Chemistry, 10 May 2018 DOI: 10.1038/s41557-018-0039-2
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Targeting a subpocket in Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) enables the structure-based discovery of selective inhibitors with trypanocidal activity Journal Of Medicinal Chemistry, Apr 2018 DOI: 10.1021/acs.jmedchem.7b01670
Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2( 1H )-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition Bioorganic & Medicinal Chemistry, Apr 2018 DOI: 10.1016/j.bmc.2018.04.033
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Unusual constriction zones in the major porins OmpU and OmpT from Vibrio cholerae Structure, Apr 2018 DOI: 10.1016/j.str.2018.03.010
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A new family of periplasmic-binding proteins that sense arsenic oxyanions Scientific Reports, 8 Apr 2018 DOI: 10.1038/s41598-018-24591-w
Characterization and engineering of a plastic-degrading aromatic polyesterase Proceedings Of The National Academy Of Sciences, 39 Apr 2018 DOI: 10.1073/pnas.1718804115
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I23-Long wavelength MX open access
Inscuteable: No longer inscrutable Apr 2018
Science Highlight I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures Proceedings Of The National Academy Of Sciences, 265 Mar 2018 DOI: 10.1073/pnas.1710741115
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A multidisciplinary study of 3-(β- d -glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors European Journal Of Medicinal Chemistry, 147 Mar 2018 DOI: 10.1016/j.ejmech.2018.01.095
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A fragment-based approach to targeting inosine-5´-monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis Journal Of Medicinal Chemistry, Mar 2018 DOI: 10.1021/acs.jmedchem.7b01622
Structures of monomeric and oligomeric forms of the Toxoplasma gondii perforin-like protein 1 Science Advances, 4 Mar 2018 DOI: 10.1126/sciadv.aaq0762
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural analysis of a GalNAc-T2 mutant reveals an induced-fit catalytic mechanism for GalNAc-Ts Chemistry - A European Journal, Mar 2018 DOI: 10.1002/chem.201800701
Journal Paper I04-Macromolecular Crystallography
Insc:LGN tetramers promote asymmetric divisions of mammary stem cells Nature Communications, 9 Mar 2018 DOI: 10.1038/s41467-018-03343-4
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Cork-in-bottle occlusion of fluoride ion channels by crystallization chaperones Structure, Mar 2018 DOI: 10.1016/j.str.2018.02.004
Discovery and characterization of ZUFSP/ZUP1, a distinct deubiquitinase class important for genome stability Molecular Cell, Mar 2018 DOI: 10.1016/j.molcel.2018.02.023
A structurally conserved motif in γ-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping Nucleic Acids Research, 332 Mar 2018 DOI: 10.1093/nar/gky217
Structural studies of DNA-binding metal complexes of therapeutic importance Mar 2018
Book Chapter I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD Scientific Reports, 8 Mar 2018 DOI: 10.1038/s41598-018-22986-3
The partial dissociation of MHC class I bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1 Journal Of Biological Chemistry, Mar 2018 DOI: 10.1074/jbc.RA117.000313
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Halogen-aromatic π-interactions modulate inhibitor residence time Angewandte Chemie International Edition, Mar 2018 DOI: 10.1002/anie.201801666
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Exploration of strategies for mechanism-based inhibitor design for family GH99 endo-α-1,2-mannanases Chemistry - A European Journal, Mar 2018 DOI: 10.1002/chem.201800435
High resolution crystal structures of the receptor-binding domain of Clostridium botulinum neurotoxin serotypes A and FA Peerj, 6 Mar 2018 DOI: 10.7717/peerj.4552
A complete structural characterization of the desferrioxamine E biosynthetic pathway from the fire blight pathogen Erwinia amylovora Journal Of Structural Biology, Feb 2018 DOI: 10.1016/j.jsb.2018.02.002
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies Proceedings Of The National Academy Of Sciences, 35 Feb 2018 DOI: 10.1073/pnas.1710617115
Architecture and hydration of the arginine-binding site of neuropilin-1 The Febs Journal, Feb 2018 DOI: 10.1111/febs.14405
Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3 Journal Of Biological Chemistry, Feb 2018 DOI: 10.1074/jbc.RA118.001796
High-throughput kinetic analysis for target-directed covalent ligand discovery Angewandte Chemie International Edition, Feb 2018 DOI: 10.1002/anie.201711825
Structural insight into the Zika virus capsid encapsulating the viral genome Cell Research, 387 Feb 2018 DOI: 10.1038/s41422-018-0007-9
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Directed evolution of alcohol dehydrogenase for improved stereoselective redox transformations of 1-phenylethane-1,2-diol and its corresponding acyloin Biochemistry, Feb 2018 DOI: 10.1021/acs.biochem.8b00055
Journal Paper I04-Macromolecular Crystallography
Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3 Journal Of Neurochemistry, Feb 2018 DOI: 10.1111/jnc.14322
Journal Paper I04-Macromolecular Crystallography
Design of tryptophan-containing mutants of the symmetrical Pizza protein for biophysical studies Biochemical And Biophysical Research Communications, Feb 2018 DOI: 10.1016/j.bbrc.2018.02.168
Journal Paper I04-Macromolecular Crystallography
RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases Plos Pathogens, 14 Feb 2018 DOI: 10.1371/journal.ppat.1006897
Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA Chemmedchem, Feb 2018 DOI: 10.1002/cmdc.201700774
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
In vitro and in vivo characterization of three Cellvibrio japonicus glycoside hydrolase family 5 members reveals potent xyloglucan backbone-cleaving functions Biotechnology For Biofuels, 11 Feb 2018 DOI: 10.1186/s13068-018-1039-6
Second-generation CK2α inhibitors targeting the αD pocket Chemical Science, 9 Feb 2018 DOI: 10.1039/C7SC05122K
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions Science, 359 Feb 2018 DOI: 10.1126/science.aam7229
Characterization of the fast and promiscuous macrocyclase from plant PCY1 enables the use of simple substrates Acs Chemical Biology, Jan 2018 DOI: 10.1021/acschembio.8b00050
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Engineering the “missing link” in biosynthetic (−)-menthol production: bacterial isopulegone isomerase Acs Catalysis, Jan 2018 DOI: 10.1021/acscatal.7b04115
The nature and reactivity of ferryl heme in compounds I and II Accounts Of Chemical Research, Jan 2018 DOI: 10.1021/acs.accounts.7b00463
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure Nature Communications, 9 Jan 2018 DOI: 10.1038/s41467-017-02361-y
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components Nature Communications, 9 Jan 2018 DOI: 10.1038/s41467-017-02570-5
Crystal structure of the outer membrane protein OmpU from Vibrio cholerae at 2.2 Å resolution Acta Crystallographica Section D Structural Biology, 74 Jan 2018 DOI: 10.1107/S2059798317017697
Structural basis for chitin acquisition by marine Vibrio species Nature Communications, 9 Jan 2018 DOI: 10.1038/s41467-017-02523-y
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
An update on factor XI structure and function Thrombosis Research, 161 Jan 2018 DOI: 10.1016/j.thromres.2017.10.008
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Structural basis for DNA 3′-end processing by human tyrosyl-DNA phosphodiesterase 1 Nature Communications, 9 Jan 2018 DOI: 10.1038/s41467-017-02530-z
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
A study of the molecular regulation of trypanosomatid phosphofructokinases as drug targets Jan 2018
Thesis I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family Scientific Reports, 8 Jan 2018 DOI: 10.1038/s41598-018-19192-6
Enzyme crystals and hydrogel composite membranes as new active food packaging material Global Challenges, 65 Jan 2018 DOI: 10.1002/gch2.201700089
The structure of the binary methyltransferase-SAH complex from Zika virus reveals a novel conformation for the mechanism of mRNA capping Oncotarget, 9 Jan 2018 DOI: 10.18632/oncotarget.23223
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Activity of factor XII-Locarno Research And Practice In Thrombosis And Haemostasis, 2 Jan 2018 DOI: 10.1002/rth2.12054
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
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- [Thesis] Laura Tuck, "A structural and synthetic biology study of bacterial microcompartments" (2018)
- David Heidenreich, Moses Moustakim, Jurema Schmidt, Daniel Merk, Paul E. Brennan, Oleg Fedorov, Apirat Chaikuad, Stefan Knapp, "A structure-based approach towards identification of inhibitory fragments for eleven-nineteen-leukemia protein (ENL)", Journal Of Medicinal Chemistry (2018), DOI: 10.1021/acs.jmedchem.8b01457
- Christopher A. Luckhurst, Omar Aziz, Vahri Beaumont, Roland W. Bürli, Perla Breccia, Michel C. Maillard, Alan F. Haughan, Marieke Lamers, Phil Leonard, Kim L. Matthews, Gilles Raphy, Andrew J. Stott, Ignacio Munoz-Sanjuan, Beth Thomas, Michael Wall, Grant Wishart, Dawn Yates, Celia Dominguez, "Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor", Bioorganic & Medicinal Chemistry Letters (2018), DOI: 10.1016/j.bmcl.2018.11.009
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- [Thesis] Joel Mcmillan, "Identification of fragments binding to CHD1 double chromodomain, an epigenetic reader of KDM1A K114me2 and H3 K4me3" (2018)
- [Thesis] Johan C. Hill, "Structural characterisation of calnexin cycle components and assessment as antiviral targets" (2018)
- Simon Leiris, Alicia Coelho, Jérôme Castandet, Maëlle Bayet, Clarisse Lozano, Juliette Bougnon, Justine Bousquet, Martin John Everett, Marc Lemonnier, Nicolas Sprynski, Magdalena Zalacain, Thomas David Pallin, Michael Cramp, Neil Jennings, Gilles Raphy, Mark William Jones, Ramesh Pattipati, Battu Shankar, Relangi Sivasubrahmanyam, Ashok Kumar Soodhagani, Ramakrishna Reddy Juventhala, Narender Pottabathini, Srinivasu Pothukanuri, Manuela Benvenuti, Cecilia Pozzi, Stefano Mangani, Filomena De Luca, Giulia Cerboni, Jean-Denis Docquier, David Davies, "SAR studies leading to the identification of a novel series of metallo-β-lactamase inhibitors for the treatment of carbapenem-resistant Enterobacteriaceae infections that display efficacy in an animal infection model", Acs Infectious Diseases (2018), DOI: 10.1021/acsinfecdis.8b00246
- Marta Artola, Chi-Lin Kuo, Stephen Mcmahon, Verena Oehler, Thomas Hansen, Martijn Van der lienden, Xu He, Hans Van den elst, Bogdan I. Florea, Allison R. Kermode, Gijsbert A. Van der marel, Tracey M. Gloster, Jeroen D. C. Codée, Herman S. Overkleeft, Johannes M. F. G. Aerts, "New irreversible α- l -Iduronidase inhibitors and activity-based probes", Chemistry - A European Journal, 42 (2018), DOI: 10.1002/chem.201804662
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- [Book Chapter] Christine J. Cardin, James Hall, "Structural studies of DNA-binding metal complexes of therapeutic importance" (2018)
- Francisco Leisico, Diana V. Vieira, Teresa A. Figueiredo, Micael Silva, Eurico J. Cabrita, Rita G. Sobral, Ana Madalena Ludovice, Jose Trincao, Maria João Romão, Hermínia De Lencastre, Teresa Santos-Silva, "First insights of peptidoglycan amidation in Gram-positive bacteria - the high-resolution crystal structure of Staphylococcus aureus glutamine amidotransferase GatD", Scientific Reports, 8 (2018), DOI: 10.1038/s41598-018-22986-3
- Athanasios Papakyriakou, Emma Reeves, Mary Beton, Halina Mikolajek, Leon Douglas, Grace Cooper, Tim Elliott, Jörn M. Werner, Edward James, "The partial dissociation of MHC class I bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1", Journal Of Biological Chemistry (2018), DOI: 10.1074/jbc.RA117.000313
- Christina Heroven, Victoria Georgi, Gaurav K. Ganotra, Paul E. Brennan, Finn Wolfreys, Rebecca C. Wade, Amaury E. Fernández-Montalván, Apirat Chaikuad, Stefan Knapp, "Halogen-aromatic π-interactions modulate inhibitor residence time", Angewandte Chemie International Edition (2018), DOI: 10.1002/anie.201801666
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- Jonathan R. Davies, Gavin S. Hackett, Sai Man Liu, Ravi Acharya, "High resolution crystal structures of the receptor-binding domain of Clostridium botulinum neurotoxin serotypes A and FA", Peerj, 6 (2018), DOI: 10.7717/peerj.4552
- Marco Salomone-Stagni, Joseph D. Bartho, Ivan Polsinelli, Dom Bellini, Martin Walsh, Nicola Demitri, Stefano Benini, "A complete structural characterization of the desferrioxamine E biosynthetic pathway from the fire blight pathogen Erwinia amylovora", Journal Of Structural Biology (2018), DOI: 10.1016/j.jsb.2018.02.002
- Kirby N. Swatek, Martina Aumayr, Jonathan N. Pruneda, Linda J. Visser, Stephen Berryman, Anja F. Kueck, Paul P. Geurink, Huib Ovaa, Frank J. M. Van Kuppeveld, Tobias J. Tuthill, Tim Skern, David Komander, "Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies", Proceedings Of The National Academy Of Sciences, 35 (2018), DOI: 10.1073/pnas.1710617115
- Filipa Mota, Constantina Fotinou, Rohini Rhana, A. W. Edith Chan, Tamas Yelland, Mohamed T. Arooz, Andrew P. O'Leary, Jennie Hutton, Paul Frankel, Ian Zachary, David Selwood, Snezana Djordjevic, "Architecture and hydration of the arginine-binding site of neuropilin-1", The Febs Journal (2018), DOI: 10.1111/febs.14405
- Diego Esposito, Regina A. Günster, Luigi Martino, Kamel El Omari, Armin Wagner, Teresa L. M. Thurston, Katrin Rittinger, "Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3", Journal Of Biological Chemistry (2018), DOI: 10.1074/jbc.RA118.001796
- Gregory B. Craven, Dominic P. Affron, Charlotte E. Allen, Stefan Matthies, Joe G. Greener, Rhodri M. L. Morgan, Edward W. Tate, Alan Armstrong, David J. Mann, "High-throughput kinetic analysis for target-directed covalent ligand discovery", Angewandte Chemie International Edition (2018), DOI: 10.1002/anie.201711825
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- Emil Hamnevik, Dirk Maurer, Thilak Reddy Enugala, Thao Chu, Robin Löfgren, Doreen Dobritzsch, Mikael Widersten, "Directed evolution of alcohol dehydrogenase for improved stereoselective redox transformations of 1-phenylethane-1,2-diol and its corresponding acyloin", Biochemistry (2018), DOI: 10.1021/acs.biochem.8b00055
- Srinivas Kumar Ponna, Salla Ruskamo, Matti Myllykoski, Corinna Keller, Tobias M. Boeckers, Petri Kursula, "Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3", Journal Of Neurochemistry (2018), DOI: 10.1111/jnc.14322
- Hiroki Noguchi, Bram Mylemans, Elke De Zitter, Luc Van Meervelt, Jeremy R. H. Tame, Arnout Voet, "Design of tryptophan-containing mutants of the symmetrical Pizza protein for biophysical studies", Biochemical And Biophysical Research Communications (2018), DOI: 10.1016/j.bbrc.2018.02.168
- Yi-Han Lin, María Lucas, Timothy R. Evans, Guillermo Abascal-Palacios, Alexandra G. Doms, Nicole A. Beauchene, Adriana L. Rojas, Aitor Hierro, Matthias P. Machner, "RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases", Plos Pathogens, 14 (2018), DOI: 10.1371/journal.ppat.1006897
- Federica Prati, Fabio Zuccotto, Daniel Fletcher, Maire A. Convery, Raquel Fernandez-Menendez, Robert Bates, Lourdes Encinas, Jingkun Zeng, Chun-Wa Chung, Paco De Dios Anton, Alfonso Mendoza-Losana, Claire Mackenzie, Simon R. Green, Margaret Huggett, David Barros, Paul G. Wyatt, Peter C. Ray, "Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA", Chemmedchem (2018), DOI: 10.1002/cmdc.201700774
- Mohamed A. Attia, Cassandra E. Nelson, Wendy A. Offen, Namrata Jain, Gideon J. Davies, Jeffrey G. Gardner, Harry Brumer, "In vitro and in vivo characterization of three Cellvibrio japonicus glycoside hydrolase family 5 members reveals potent xyloglucan backbone-cleaving functions", Biotechnology For Biofuels, 11 (2018), DOI: 10.1186/s13068-018-1039-6
- Jessica Iegre, Paul Brear, Claudia De Fusco, Masao Yoshida, Sophie L. Mitchell, Maxim Rossmann, Laura Carro, Hannah F. Sore, Marko Hyvonen, David R. Spring, "Second-generation CK2α inhibitors targeting the αD pocket", Chemical Science, 9, 3041 - 3049 (2018), DOI: 10.1039/C7SC05122K
- Georg K. A. Hochberg, Dale A. Shepherd, Erik G. Marklund, Indu Santhanagoplan, Matteo T. Degiacomi, Arthur Laganowsky, Timothy M. Allison, Eman Basha, Michael T. Marty, Martin R. Galpin, Weston B. Struwe, Andrew J. Baldwin, Elizabeth Vierling, Justin L. P. Benesch, "Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions", Science, 359, 930 - 935 (2018), DOI: 10.1126/science.aam7229
- Hannes Ludewig, Clarissa M. Czekster, Emilia Oueis, Elizabeth S. Munday, Mohammed Arshad, Silvia A. Synowsky, Andrew F. Bent, James H. Naismith, "Characterization of the fast and promiscuous macrocyclase from plant PCY1 enables the use of simple substrates", Acs Chemical Biology (2018), DOI: 10.1021/acschembio.8b00050
- Andrew Currin, Mark S. Dunstan, Linus O. Johannissen, Katherine A. Hollywood, Maria Vinaixa, Adrian J. Jervis, Neil Swainston, Nicholas J. W. Rattray, John M. Gardiner, Douglas B. Kell, Eriko Takano, Helen S. Toogood, Nigel S. Scrutton, "Engineering the “missing link” in biosynthetic (−)-menthol production: bacterial isopulegone isomerase", Acs Catalysis (2018), DOI: 10.1021/acscatal.7b04115
- Peter C. E. Moody, Emma L. Raven, "The nature and reactivity of ferryl heme in compounds I and II", Accounts Of Chemical Research (2018), DOI: 10.1021/acs.accounts.7b00463
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- [Thesis] James R. H. Kinkead, "A study of the molecular regulation of trypanosomatid phosphofructokinases as drug targets" (2018)
- Mohammad Mubinur Rahman, Martina Andberg, Anu Koivula, Juha Rouvinen, Nina Hakulinen, "The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family", Scientific Reports, 8 (2018), DOI: 10.1038/s41598-018-19192-6
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