Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
111 items found for 2013 [total: 2283]
Conformational plasticity at the IgE-binding site of the B-cell receptor CD23 Molecular Immunology, 56 (4) Dec 2013 DOI: 10.1016/j.molimm.2013.07.005
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Complementary studies of the role of metals in the conformation and interactions of serum amyloid P component and β-amyloid Aβ42 Dec 2013
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Discovery and characterization of a new family of lytic polysaccharide monooxygenases Nature Chemical Biology, Dec 2013 DOI: 10.1038/nchembio.1417
Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3 Journal Of Medicinal Chemistry, 56 (23) Dec 2013 DOI: 10.1021/jm401394u
Journal Paper I04-Macromolecular Crystallography
Structural basis of AMPK regulation by small molecule activators Nature Communications, 4 Dec 2013 DOI: 10.1038/ncomms4017
Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1) Journal Of Medicinal Chemistry, 56 (24) Dec 2013 DOI: 10.1021/jm401395s
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural basis of lentiviral subversion of a cellular protein degradation pathway Nature, 505 (7482) Dec 2013 DOI: 10.1038/nature12815
Crystallization and preliminary X-ray crystallographic analysis of the curli transporter CsgG Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Dec 2013 DOI: 10.1107/S1744309113028054
Journal Paper I04-Macromolecular Crystallography
Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens Acta Crystallographica Section D Biological Crystallography, 69 Dec 2013 DOI: 10.1107/S0907444913022725
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach Nature Chemistry, 6 (2) Dec 2013 DOI: 10.1038/nchem.1830
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay Biochemistry, 52 (51) Dec 2013 DOI: 10.1021/bi400945y
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington’s disease Journal Of Medicinal Chemistry, 56 (24) Dec 2013 DOI: 10.1021/jm4011884
Journal Paper I04-Macromolecular Crystallography
Crystallization and preliminary crystallographic analysis of a surface antigen glycoprotein, SAG19, from Eimeria tenella Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Dec 2013 DOI: 10.1107/S1744309113029734
Journal Paper I04-Macromolecular Crystallography
Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes Plos One, 8 (11) Nov 2013 DOI: 10.1371/journal.pone.0079349
Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre Molecular Microbiology, Nov 2013 DOI: 10.1111/mmi.12447
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Solution and crystallographic structures of the central region of the phosphoprotein from human metapneumovirus Plos One, 8 (11) Nov 2013 DOI: 10.1371/journal.pone.0080371
Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme Febs Journal, Nov 2013 DOI: 10.1111/febs.12660
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure and assembly of an inner membrane platform for initiation of type IV pilus biogenesis Proceedings Of The National Academy Of Sciences, Nov 2013 DOI: 10.1073/pnas.1312313110
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin Nature Communications, 4 Nov 2013 DOI: 10.1038/ncomms3787
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural analysis of the G-Box domain of the microcephaly protein CPAP suggests a role in centriole architecture Structure, 21 (11) Nov 2013 DOI: 10.1016/j.str.2013.08.019
Potential regulatory interactions of Escherichia coli RraA protein with DEAD-box helicases Journal Of Biological Chemistry, 288 (44) Nov 2013 DOI: 10.1074/jbc.M113.502146
Crystallization and preliminary crystallographic analysis of GanB, a GH42 intracellular â-galactosidase from Geobacillus stearothermophilus Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Oct 2013 DOI: 10.1107/S1744309113023609
Journal Paper I04-Macromolecular Crystallography
Plug-and-play pairing via defined divalent streptavidins Journal Of Molecular Biology, Oct 2013 DOI: 10.1016/j.jmb.2013.09.016
Screening protein - Single stranded RNA complexes by NMR spectroscopy for structure determination Methods, Oct 2013 DOI: 10.1016/j.ymeth.2013.09.018
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A structural and dynamic investigation of the inhibition of catalase by nitric oxide Organic & Biomolecular Chemistry, 11 (44) Oct 2013 DOI: 10.1039/c3ob41977k
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure of UreG/UreF/UreH complex reveals how urease accessory proteins facilitate maturation of Helicobacter pylori urease Plos Biology, 11 (10) Oct 2013 DOI: 10.1371/journal.pbio.1001678
Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency Plos Pathogens, 9 Oct 2013 DOI: 10.1371/journal.ppat.1003673
Structural investigation of a viral ortholog of human NEIL2/3 DNA glycosylases Dna Repair, Oct 2013 DOI: 10.1016/j.dnarep.2013.09.004
Journal Paper I04-Macromolecular Crystallography
Genetically encoding phenyl azide chemistry: new uses and ideas for classical biochemistry Biochemical Society Transactions, 41 Oct 2013 DOI: 10.1042/BST20130094
Conference Paper I04-Macromolecular Crystallography
High-resolution structure of an atypical α-phosphoglucomutase related to eukaryotic phosphomannomutases Acta Crystallographica Section D Biological Crystallography, 69 Oct 2013 DOI: 10.1107/S0907444913017046
Journal Paper I04-Macromolecular Crystallography
Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding Acta Crystallographica Section D Biological Crystallography, 69 Sept 2013 DOI: 10.1107/S0907444913014418
Journal Paper I04-Macromolecular Crystallography
Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly Elife, 2 Sept 2013 DOI: 10.7554/eLife.01071
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors Plos Biology, 11 (9) Sept 2013 DOI: 10.1371/journal.pbio.1001651
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 post-fusion architecture with extensive glycosylation Journal Of Virology, Sept 2013 DOI: 10.1128/JVI.02298-13
Crystal structure of sialylated IgG Fc: Implications for the mechanism of intravenous immunoglobulin therapy Proceedings Of The National Academy Of Sciences, 110 (38) Sept 2013 DOI: 10.1073/pnas.1310657110
Journal Paper I04-Macromolecular Crystallography
Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases Bioorganic & Medicinal Chemistry, 21 (18) Sept 2013 DOI: 10.1016/j.bmc.2013.07.021
Inversion of enantioselectivity of a mononuclear non-heme iron(II)-dependent hydroxylase by tuning the interplay of metal-center geometry and protein structure Angewandte Chemie International Edition, 52 (37) Sept 2013 DOI: 10.1002/anie.201304633
Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains Chemical Communications, 49 (73) Sept 2013 DOI: 10.1039/c3cc42709a
A high-resolution structure that provides insight into coiled-coil thiodepsipeptide dynamic chemistry Angewandte Chemie International Edition, 52 (38) Sept 2013 DOI: 10.1002/anie.201303900
Journal Paper I04-Macromolecular Crystallography
The putative small terminase from the thermophilic dsDNA bacteriophage G20C is a nine-subunit oligomer Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Aug 2013 DOI: 10.1107/S1744309113017016
Optimization of bimorph mirrors on x-ray synchrotron beamlines SPIE Newsroom, Aug 2013 DOI: 10.1117/2.1201308.005021
Magazine Article B16-Test Beamline I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I19-Small Molecule Single Crystal Diffraction I22-Small angle scattering & Diffraction I24-Microfocus Macromolecular Crystallography
Structural rearrangement in an RsmA/CsrA ortholog of Pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN Structure, Aug 2013 DOI: 10.1016/j.str.2013.07.007
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Evolution of substrate specificity in a recipient’s enzyme following horizontal gene transfer Molecular Biology And Evolution, 30 (9) Aug 2013 DOI: 10.1093/molbev/mst115
Structure and mechanism of acetolactate decarboxylase Acs Chemical Biology, 8 (10) Aug 2013 DOI: 10.1021/cb400429h
Journal Paper I04-Macromolecular Crystallography
X-ray crystal structure of rac-[Ru(phen)2dppz]2+ with d(ATGCAT)2 shows enantiomer orientations and water ordering Journal Of The American Chemical Society, 135 (34) Jul 2013 DOI: 10.1021/ja403590e
Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3 Nature Structural & Molecular Biology, 20 (8) Jul 2013 DOI: 10.1038/nsmb.2621
Visualization of membrane protein crystals in lipid cubic phase using X-ray imaging Acta Crystallographica Section D Biological Crystallography, 69 Jul 2013 DOI: 10.1107/S0907444913011359
Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography Acta Crystallographica Section D Biological Crystallography, 69 Jul 2013 DOI: 10.1107/S0907444913012274
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis Blood, Jul 2013 DOI: 10.1182/blood-2013-06-511733
Journal Paper I04-Macromolecular Crystallography
Squeezing the most from every crystal: the fine details of data collection Acta Crystallographica Section D Biological Crystallography, 69 Jul 2013 DOI: 10.1107/S0907444913013280
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism Rna, 19 (8) Jul 2013 DOI: 10.1261/rna.039057.113
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR) Plos Pathogens, 9 (7) Jul 2013 DOI: 10.1371/journal.ppat.1003508
The mannose-specific lectin domains of Flo1p from Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Jul 2013 DOI: 10.1107/S1744309113015030
Journal Paper I04-Macromolecular Crystallography
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation Proceedings Of The National Academy Of Sciences, Jul 2013 DOI: 10.1073/pnas.1311113110
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Synthesis of α-glucan in mycobacteria involves a hetero-octameric complex of trehalose synthase TreS and maltokinase Pep2 Acs Chemical Biology, 8 (10) Jul 2013 DOI: 10.1021/cb400508k
An activating mutation reveals a second binding mode of the integrin α2 I domain to the GFOGER motif in collagens Plos One, 8 (7) Jul 2013 DOI: 10.1371/journal.pone.0069833
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis Cell, 154 (1) Jul 2013 DOI: 10.1016/j.cell.2013.05.046
Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products Journal Of The American Chemical Society, 135 (29) Jul 2013 DOI: 10.1021/ja4051235
Journal Paper I04-Macromolecular Crystallography
Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets Cell Reports, 4 (1) Jul 2013 DOI: 10.1016/j.celrep.2013.06.008
The dimeric form of the unphosphorylated response regulator BaeR Protein Science, Jul 2013 DOI: 10.1002/pro.2311
The BAH domain of Rsc2 is a histone H3 binding domain Nucleic Acids Research, Jul 2013 DOI: 10.1093/nar/gkt662
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structural characterization of a unique marine animal family 7 cellobiohydrolase suggests a mechanism of cellulase salt tolerance Proceedings Of The National Academy Of Sciences, 110 (25) June 2013 DOI: 10.1073/pnas.1301502110
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2 Plos One, 8 (6) June 2013 DOI: 10.1371/journal.pone.0065689
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Unusual base pairing during the decoding of a stop codon by the ribosome Nature, 500 (7460) June 2013 DOI: 10.1038/nature12302
Journal Paper I04-Macromolecular Crystallography
Receptor binding by an H7N9 influenza virus from humans Nature, June 2013 DOI: 10.1038/nature12372
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Engineering hydrophobic protein-carbohydrate interactions to fine-tune monoclonal antibodies Journal Of The American Chemical Society, 135 (26) June 2013 DOI: 10.1021/ja4014375
Structure of PatF from Prochloron didemni Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 June 2013 DOI: 10.1107/S1744309113012931
Structurally encoded intraclass differences in EphA clusters drive distinct cell responses Nature Structural & Molecular Biology, 20 (8) June 2013 DOI: 10.1038/nsmb.2617
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing Biochemical Journal, 452 June 2013 DOI: 10.1042/BJ20130269
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3 Acs Chemical Biology, 8 (8) June 2013 DOI: 10.1021/cb4002014
Journal Paper I04-Macromolecular Crystallography
Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein Genes & Development, 27 (11) June 2013 DOI: 10.1101/gad.212381.112
Elongation factor G bound to the ribosome in an intermediate state of translocation Science, 340 (6140) June 2013 DOI: 10.1126/science.1235490
Journal Paper I04-Macromolecular Crystallography
S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA Acta Crystallographica Section D Biological Crystallography, 69 June 2013 DOI: 10.1107/S0907444913004939
Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression Journal Of Biological Chemistry, 288 (23) June 2013 DOI: 10.1074/jbc.M112.420521
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Mechanistic studies of acetolactate decarboxylase June 2013
Thesis I04-Macromolecular Crystallography
Crystal structure of a bioactive pactamycin analog bound to the 30S ribosomal subunit Journal Of Molecular Biology, May 2013 DOI: 10.1016/j.jmb.2013.05.004
Structural basis for recognition of the pore-forming toxin intermedilysin by human complement receptor CD59 Cell Reports, May 2013 DOI: 10.1016/j.celrep.2013.04.029
T-cell receptor specificity maintained by altered thermodynamics Journal Of Biological Chemistry, May 2013 DOI: 10.1074/jbc.M113.464560
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
‘In crystallo’ substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase Acta Crystallographica Section D Biological Crystallography, 69 May 2013 DOI: 10.1107/S0907444913013875
Degradation of phytate by the 6-phytase from Hafnia alvei: a combined structural and solution study Plos One, 8 (5) May 2013 DOI: 10.1371/journal.pone.0065062
PFI-1, a highly selective protein interaction inhibitor, targeting BET bromodomains Cancer Research, 73 (11) May 2013 DOI: 10.1158/0008-5472.CAN-12-3292
Journal Paper I04-Macromolecular Crystallography
Structure of the human Parkin ligase domain in an autoinhibited state The Embo Journal, 32 (15) May 2013 DOI: 10.1038/emboj.2013.125
Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells Journal Of Medicinal Chemistry, 56 (7) Apr 2013 DOI: 10.1021/jm301899y
Journal Paper I04-Macromolecular Crystallography
Structural and functional insights into Saccharomyces cerevisiae riboflavin biosynthesis reductase RIB7 Plos One, 8 (4) Apr 2013 DOI: 10.1371/journal.pone.0061249
Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes Science, Apr 2013 DOI: 10.1126/science.1235822
Journal Paper I04-Macromolecular Crystallography
Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution Structure, Apr 2013 DOI: 10.1016/j.str.2013.03.008
Structural basis of kynurenine 3-monooxygenase inhibition Nature, Apr 2013 DOI: 10.1038/nature12039
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Bacteriophage P23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage Structure, Apr 2013 DOI: 10.1016/j.str.2013.02.026
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization Nucleic Acids Research, Apr 2013 DOI: 10.1093/nar/gkt268
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A new class of small molecule inhibitor of BMP signaling Plos One, 8 (4) Apr 2013 DOI: 10.1371/journal.pone.0062721
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system Nature Chemical Biology, 9 Apr 2013 DOI: 10.1038/nchembio.1212
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
The four canonical TPR subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix Journal Of Molecular Biology, Apr 2013 DOI: 10.1016/j.jmb.2013.04.004
Synthesis and structure–activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3 European Journal Of Medicinal Chemistry, 62 Apr 2013 DOI: 10.1016/j.ejmech.2013.01.047
Journal Paper I04-Macromolecular Crystallography
Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum Acta Crystallographica Section D Biological Crystallography, 69 Mar 2013 DOI: 10.1107/S0907444912049001
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Crystal structures of the catalytic domain of human soluble guanylate cyclase Plos One, 8 (3) Mar 2013 DOI: 10.1371/journal.pone.0057644
Structure of the catalytic region of DNA Ligase IV in complex with an artemis fragment sheds light on double-strand break repair Structure, Mar 2013 DOI: 10.1016/j.str.2013.02.014
Self-assembly and conformational heterogeneity of the AXH domain of Ataxin-1: an unusual example of a chameleon fold Biophysical Journal, 104 (6) Mar 2013 DOI: 10.1016/j.bpj.2013.01.048
M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation Proceedings Of The National Academy Of Sciences, Mar 2013 DOI: 10.1073/pnas.1217157110
Structure of Schmallenberg orthobunyavirus nucleoprotein suggests a novel mechanism for genome encapsidation Journal Of Virology, Mar 2013 DOI: 10.1128/JVI.00223-13
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90 Nature Chemistry, 5 (4) Mar 2013 DOI: 10.1038/nchem.1596
Journal Paper I04-Macromolecular Crystallography
Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD–YeaZ–YjeE complex Protein Science, 22 (5) Mar 2013 DOI: 10.1002/pro.2247
Journal Paper I04-Macromolecular Crystallography
Insights into the structure and assembly of the Bacillus subtilis clamp-loader complex and its interaction with the replicative helicase Nucleic Acids Research, 41 (9) Mar 2013 DOI: 10.1093/nar/gkt173
On terminal alkynes that can react with active-site cysteine nucleophiles in proteases Journal Of The American Chemical Society, 135 (8) Feb 2013 DOI: 10.1021/ja309802n
Structural insights into the regulation of cohesion establishment by Wpl1 The Embo Journal, Feb 2013 DOI: 10.1038/emboj.2013.16
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Understanding how noncatalytic carbohydrate binding modules can display specificity for xyloglucan Journal Of Biological Chemistry, 288 (7) Feb 2013 DOI: 10.1074/jbc.M112.432781
The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Jan 2013 DOI: 10.1107/S1744309112044739
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues Acta Crystallographica Section D Biological Crystallography, 69 Jan 2013 DOI: 10.1107/S0907444912044800
Journal Paper I04-Macromolecular Crystallography
Using a fragment-based approach to target protein–protein interactions Chembiochem, 14 (3) Jan 2013 DOI: 10.1002/cbic.201200521
Biocatalytic asymmetric alkene reduction: crystal structure and characterization of a double bond reductase from Nicotiana tabacum Acs Catalysis, 3 (3) Jan 2013 DOI: 10.1021/cs300709m
Structural basis for duplex RNA recognition and cleavage by Archaeoglobus fulgidus C3PO Nature Structural & Molecular Biology, Jan 2013 DOI: 10.1038/nsmb.2487
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structure and activity of the Streptococcus pyogenes family GH1 6-phospho-β-glucosidase SPy1599 Acta Crystallographica Section D Biological Crystallography, 69 Jan 2013 DOI: 10.1107/S0907444912041005
- Balvinder Dhaliwal, Marie O. Y. Pang, Daopeng Yuan, Norhakim Yahya, Stella Fabiane, James M. Mcdonnell, Hannah J. Gould, Andrew J. Beavil, Brian J. Sutton, "Conformational plasticity at the IgE-binding site of the B-cell receptor CD23", Molecular Immunology, 56 (4), 693 - 697 (2013), DOI: 10.1016/j.molimm.2013.07.005
- [Thesis] Matthew Mold, "Complementary studies of the role of metals in the conformation and interactions of serum amyloid P component and β-amyloid Aβ42" (2013)
- Glyn Hemsworth, Bernard Henrissat, Gideon J. Davies, Paul H. Walton, "Discovery and characterization of a new family of lytic polysaccharide monooxygenases", Nature Chemical Biology (2013), DOI: 10.1038/nchembio.1417
- Anders E. G. Lindgren, Tobias Karlberg, Torun Ekblad, Sara Spjut, Ann-Gerd Thorsell, C. David Andersson, Ton Tong Nhan, Victor Hellsten, Johan Weigelt, Anna Linusson, Herwig Schüler, Mikael Elofsson, "Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3", Journal Of Medicinal Chemistry, 56 (23), 9556 - 9568 (2013), DOI: 10.1021/jm401394u
- Bing Xiao, Matthew J. Sanders, David Carmena, Nicola J. Bright, Lesley F. Haire, Elizabeth Underwood, Bhakti R. Patel, Richard B. Heath, Phillip A. Walker, Stefan Hallen, Fabrizio Giordanetto, Stephen R. Martin, David Carling, Steven Gamblin, "Structural basis of AMPK regulation by small molecule activators", Nature Communications, 4 (2013), DOI: 10.1038/ncomms4017
- Sébastien Naud, Isaac M. Westwood, Amir Faisal, Peter Sheldrake, Vassilios Bavetsias, Butrus Atrash, Kwai-Ming J. Cheung, Manjuan Liu, Angela Hayes, Jessica Schmitt, Amy Wood, Vanessa Choi, Kathy Boxall, Grace Mak, Mark Gurden, Melanie Valenti, Alexis De Haven Brandon, Alan Henley, Ross Baker, Craig Mcandrew, Berry Matijssen, Rosemary Burke, Swen Hoelder, Suzanne A. Eccles, Florence I. Raynaud, Spiros Linardopoulos, Rob L. M. Van Montfort, Julian Blagg, "Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)", Journal Of Medicinal Chemistry, 56 (24), 10045 - 10065 (2013), DOI: 10.1021/jm401395s
- David Schwefel, Harriet C. T. Groom, Virginie C. Boucherit, Evangelos Christodoulou, Philip A. Walker, Jonathan P. Stoye, Kate N. Bishop, Ian A. Taylor, "Structural basis of lentiviral subversion of a cellular protein degradation pathway", Nature, 505 (7482), 234 - 238 (2013), DOI: 10.1038/nature12815
- Parveen Goyal, Nani Van Gerven, Wim Jonckheere, Han Remaut, "Crystallization and preliminary X-ray crystallographic analysis of the curli transporter CsgG", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69, 1349 - 1353 (2013), DOI: 10.1107/S1744309113028054
- Velupillai Srikannathasan, Grant English, Nhat Khai Bui, Katharina Trunk, Patrick E. F. O'Rourke, Vincenzo A. Rao, Waldemar Vollmer, Sarah J. Coulthurst, William N. Hunter, "Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens", Acta Crystallographica Section D Biological Crystallography, 69, 2468 - 2482 (2013), DOI: 10.1107/S0907444913022725
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