Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
91 items found for 2011 [total: 2283]
Recognition of dual symmetry by the controller protein C.Esp1396I based on the structure of the transcriptional activation complex Nucleic Acids Research, 40 (9) Dec 2011 DOI: 10.1093/nar/gkr1250
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Use of the gamma-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells. Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 Dec 2011 DOI: 10.1107/S1744309111017672
Targeting the Hsp90 molecular chaperone with novel macrolactams. synthesis, structural, binding, and cellular studies Acs Chemical Biology, 6 (12) Dec 2011 DOI: 10.1021/cb200196e
Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension Science, 332 Dec 2011 DOI: 10.1126/science.1200840
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease Journal Of Biological Chemistry, 286 (12) Dec 2011 DOI: 10.1074/jbc.M110.177394
The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly Febs Journal, Dec 2011 DOI: 10.1111/j.1742-4658.2011.08461.x
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Dissection of the network of interactions that links RNA processing with glycolysis in the Bacillus subtilis degradosome Journal Of Molecular Biology, Dec 2011 DOI: 10.1016/j.jmb.2011.12.024
Journal Paper I04-Macromolecular Crystallography
PCNA directs type 2 RNase H activity on DNA replication and repair substrates Nucleic Acids Research, 39 (9) Dec 2011 DOI: 10.1093/nar/gkq980
Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor Fc(Epsilon)RI Nature Structural & Molecular Biology, 18 (5) Dec 2011 DOI: 10.1038/nsmb.2044
Journal Paper I04-Macromolecular Crystallography
Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis. Acta Crystallographica Section D Biological Crystallography, 67 (5) Dec 2011 DOI: 10.1107/S0907444911007888
Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering Journal Of Biological Chemistry, 286 Dec 2011 DOI: 10.1074/jbc.M110.182394
Structural basis for cell surface patterning through NetrinG-NGL interactions The Embo Journal, 30 (21) Dec 2011 DOI: 10.1038/emboj.2011.346
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII Journal Of Molecular Biology, Nov 2011 DOI: 10.1016/j.jmb.2011.10.036
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A Science, 334 Nov 2011 DOI: 10.1126/science.1211915
Journal Paper I04-Macromolecular Crystallography
The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target Molecular And Biochemical Parasitology, Nov 2011 DOI: 10.1016/j.molbiopara.2011.11.004
In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF B signalling Molecular Cancer Therapeutics, Nov 2011 DOI: 10.1158/1535-7163.MCT-11-0543
Journal Paper I04-Macromolecular Crystallography
Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation Structure, 19 (11) Nov 2011 DOI: 10.1016/j.str.2011.08.014
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure and kinetic stability of the p63 tetramerization domain Journal Of Molecular Biology, Nov 2011 DOI: 10.1016/j.jmb.2011.11.007
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor Febs Journal, Nov 2011 DOI: 10.1111/j.1742-4658.2011.08414.x
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase Nature, Nov 2011 DOI: 10.1038/nature10623
Journal Paper I04-Macromolecular Crystallography
The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM Cell, 147 (5) Nov 2011 DOI: 10.1016/j.cell.2011.10.038
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Assembly of the preactivation complex for urease maturation in Helicobacter pylori: crystal structure of the UreF/UreH complex Journal Of Biological Chemistry, 286 Oct 2011 DOI: 10.1074/jbc.M111.296830
Structural variability of the ubiquitin specific protease DUSP-UBL double domains Febs Letters, Oct 2011 DOI: 10.1016/j.febslet.2011.09.040
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystal structure of reduced and of oxidized peroxiredoxin IV reveals a stable oxidized decamer and a non disulfide-bonded intermediate in the catalytic cycle Journal Of Biological Chemistry, Oct 2011 DOI: 10.1074/jbc.M111.298810
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
A de novo peptide hexamer with a mutable channel Nature Chemical Biology, 7 (12) Oct 2011 DOI: 10.1038/nchembio.692
Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions Biochemical Society Transactions, 39 (5) Oct 2011 DOI: 10.1042/BST0391387
Journal Paper I04-Macromolecular Crystallography
Ex situ and in situ methods of inspecting and optimizing adaptive bimorph mirrors Diamond Light Source Proceedings, 1 Oct 2011 DOI: 10.1017/S2044820110000225
Conference Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I07-Surface & interface diffraction I19-Small Molecule Single Crystal Diffraction
Unusual, dual endo- and exonuclease activity in the degradosome explained by crystal structure analysis of RNase J1 Structure, 19 (9) Sept 2011 DOI: 10.1016/j.str.2011.06.017
Journal Paper I04-Macromolecular Crystallography
Novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2): crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones Journal Of Medicinal Chemistry, 54 (19) Sept 2011 DOI: 10.1021/jm200416e
Journal Paper I04-Macromolecular Crystallography
Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer Embo Reports, Sept 2011 DOI: 10.1038/embor.2011.171
Journal Paper I04-Macromolecular Crystallography
The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase Nature, 477 Sept 2011 DOI: 10.1038/nature10404
Journal Paper I04-Macromolecular Crystallography
Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin Biochemical Journal, 438 (2) Sept 2011 DOI: 10.1042/BJ20101316
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A widespread family of bacterial cell wall assembly proteins The Embo Journal, Sept 2011 DOI: 10.1038/emboj.2011.358
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion Plos One, 6 (9) Sept 2011 DOI: 10.1371/journal.pone.0024825
Expression, purification and crystallization of Neisserial outer membrane proteins Sept 2011 DOI: 10.1007/978-1-61779-346-2_6
Book Chapter I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure and activity of Paenibacillus polymyxa xyloglucanase from glycoside hydrolase family 44 Journal Of Biological Chemistry, 286 (39) Sept 2011 DOI: 10.1074/jbc.M111.262345
The three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27: a new member of the Haloalkanoic Acid Dehalogenase superfamily Biochemistry, Sept 2011 DOI: 10.1021/bi201171h
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Non-equivalent role of inter- and intra-molecular hydrogen bonds in the insulin dimer interface Journal Of Biological Chemistry, Sept 2011 DOI: 10.1074/jbc.M111.265249
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure of a Streptomyces maltosyltransferase GlgE: a homologue of a genetically validated anti-tuberculosis target Journal Of Biological Chemistry, Sept 2011 DOI: 10.1074/jbc.M111.279315
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structures of Phytophthora RXLR effector proteins: a conserved but adaptable fold underpins functional diversity Journal Of Biological Chemistry, Aug 2011 DOI: 10.1074/jbc.M111.262303
Structure of the USP15 N-terminal domains: a β-hairpin mediates close association between the DUSP and UBL domains Biochemistry, 50 (37) Aug 2011 DOI: 10.1021/bi200726e
Journal Paper I04-Macromolecular Crystallography
The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding Nucleic Acids Research, Aug 2011 DOI: 10.1093/nar/gkr640
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding Proceedings Of The National Academy Of Sciences, Aug 2011 DOI: 10.1073/pnas.1106341108
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I22-Small angle scattering & Diffraction open access
Structures of the rat complement regulator CrrY Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (7) Jul 2011 DOI: 10.1107/S1744309111016551
Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation Bioorganic & Medicinal Chemistry Letters, Jul 2011 DOI: 10.1016/j.bmcl.2011.07.041
Journal Paper I04-Macromolecular Crystallography
Crystal structure of Serratia fonticola Sfh-I: activation of the nucleophile in mono-zinc metallo-β-lactamases Journal Of Molecular Biology, Jul 2011 DOI: 10.1016/j.jmb.2011.06.043
Journal Paper I04-Macromolecular Crystallography
Expression, purification, crystallization and preliminary crystallographic analysis of a putative Clostridium difficile surface protein Cwp19 Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (7) Jul 2011 DOI: 10.1107/S1744309111016770
The light intensity at which cells are grown controls the type of peripheral light-harvesting complexes that are assembled in a purple photosynthetic bacterium Biochemical Journal, Jul 2011 DOI: 10.1042/BJ20110575
Journal Paper I04-Macromolecular Crystallography
Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90 The Faseb Journal, Jul 2011 DOI: 10.1096/fj.11-188821
Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1) Journal Of Molecular Biology, 410 (2) Jul 2011 DOI: 10.1016/j.jmb.2011.04.075
Journal Paper I04-Macromolecular Crystallography
Simultaneous X-ray diffraction from multiple single crystals of macromolecules Acta Crystallographica Section D Biological Crystallography, 67 (7) June 2011 DOI: 10.1107/S0907444911015617
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor Genes & Development, 25 (12) June 2011 DOI: 10.1101/gad.2056211
The virulence factor PEB4 (Cj0596) and the periplasmic protein Cj1289 are two structurally related SurA-like chaperones in the human pathogen Campylobacter jejuni Journal Of Biological Chemistry, 286 (24) June 2011 DOI: 10.1074/jbc.M111.220442
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Protein crystallization facilitated by molecularly imprinted polymers Proceedings Of The National Academy Of Sciences, June 2011 DOI: 10.1073/pnas.1016539108
Journal Paper I04-Macromolecular Crystallography
Mapping lipid and detergent molecules at the surface of membrane proteins June 2011 DOI: 10.1042/BST0390775
Conference Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
X-ray crystallographic structure of the murine norovirus protease at 1.66 Å resolution and functional studies of the β-ribbon June 2011
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Interaction of the p53 DNA-binding domain with its N-terminal extension modulates the stability of the p53 tetramer Journal Of Molecular Biology, 409 (3) June 2011 DOI: 10.1016/j.jmb.2011.03.047
Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis Biochemical Journal, 436 (3) June 2011 DOI: 10.1042/BJ20110002
Journal Paper I04-Macromolecular Crystallography
Structure and function of an arabinoxylan-specific xylanase Journal Of Biological Chemistry, 286 (25) June 2011 DOI: 10.1074/jbc.M110.217315
The structure of a D-lyxose isomerase from the σB regulon of Bacillus subtilis Proteins: Structure, Function, And Bioinformatics, 79 June 2011 DOI: 10.1002/prot.23028
Journal Paper I04-Macromolecular Crystallography
Bilirubin oxidase from Myrothecium verrucaria: X-ray determination of the complete crystal structure and a rational surface modification for enhanced electrocatalytic O2 reduction Dalton Transactions, 40 (25) May 2011 DOI: 10.1039/C0DT01403F
Journal Paper I04-Macromolecular Crystallography
The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains The Embo Journal, May 2011 DOI: 10.1038/emboj.2011.166
The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine Journal Of Biological Chemistry, 286 (18) May 2011 DOI: 10.1074/jbc.M111.224873
Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects Journal Of Synchrotron Radiation, 18 (3) May 2011 DOI: 10.1107/S0909049511008235
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases Embo Reports, 12 (5) Apr 2011 DOI: 10.1038/embor.2011.43
Journal Paper I04-Macromolecular Crystallography
Structural insights into the retroviral DNA integration apparatus Current Opinion In Structural Biology, 21 (2) Apr 2011 DOI: 10.1016/j.sbi.2010.12.005
A crystal structure of the complex between human complement receptor 2 and its ligand C3d Science, 332 Apr 2011 DOI: 10.1126/science.1201954
Journal Paper I04-Macromolecular Crystallography
Expression, crystallization and preliminary X-ray data analysis of NT-ALS9, a fungal adhesin from Candida albicans Acta Crystallographica Section F Structural Biology And Crystallization Communications, Apr 2011 DOI: 10.1107/S1744309111003460
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Helix-mediated protein-protein interactions as targets for intervention using foldamers Amino Acids, Mar 2011 DOI: 10.1007/s00726-011-0880-8
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67(4) Mar 2011 DOI: 10.1107/S1744309111003484
Journal Paper I04-Macromolecular Crystallography
Structural basis of telomeric RNA quadruplex−acridine ligand recognition Journal Of The American Chemical Society, 133 (8) Feb 2011 DOI: 10.1021/ja109767y
Journal Paper I04-Macromolecular Crystallography
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains Febs Letters, 278 (7) Feb 2011 DOI: 10.1111/j.1742-4658.2011.08022.x
Novel mechanism of inhibition of human Angiotensin-I converting enzyme (ACE) by a highly specific phosphinic tripeptide Biochemical Journal, Feb 2011 DOI: 10.1042/BJ20102123
Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression Journal Of Molecular Biology, Feb 2011 DOI: 10.1016/j.jmb.2011.02.035
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structure of PduT, a trimeric bacterial microcompartment protein with a 4Fe-4S cluster-binding site Acta Crystallographica Section D-Structural Biology, 67 (2) Feb 2011 DOI: 10.1107/S0907444910050201
Journal Paper I04-Macromolecular Crystallography
Structural basis for engagement by complement factor H of C3b on a self surface Nature Structural & Molecular Biology, 18 (4) Feb 2011 DOI: 10.1038/nsmb.2018
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (1) Jan 2011 DOI: 10.1107/S174430911004724X
Copper-binding properties and structures of methanobactins from Methylosinus trichosporium OB3b Inorganic Chemistry, 50(4) Jan 2011 DOI: 10.1021/ic101965j
Journal Paper I04-Macromolecular Crystallography
Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones Plos One, Jan 2011 DOI: 10.1371/journal.pone.0016583
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Phosphotyrosine recognition by the Raf kinase inhibitor protein Onco Therapeutics, 2(1) Jan 2011 DOI: 10.1615/ForumImmunDisTher.v2.i1.70
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystallization and initial crystallographic analysis of AafA: the major adhesive subunit of the enteroaggregative Escherichia coli AAF/II pilus Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (4) Jan 2011 DOI: 10.1107/S1744309111001412
Evolution in a family of chelatases facilitated by the introduction of active site asymmetry and protein oligomerization Proceedings Of The National Academy Of Sciences, 108 (1) Jan 2011 DOI: 10.1073/pnas.1014298108
Journal Paper I04-Macromolecular Crystallography
Nature of the ferryl heme in compounds I and II Journal Of Biological Chemistry, 286 Jan 2011 DOI: 10.1074/jbc.M110.183483
Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery Nature Structural & Molecular Biology, 18 (2) Jan 2011 DOI: 10.1038/nsmb.1983
Importance of single molecular determinants in the fidelity of expanded genetic codes Proceedings Of The National Academy Of Sciences, 108 (4) Jan 2011 DOI: 10.1073/pnas.1012276108
Crystal structure of DNA polymerase III β sliding clamp from Mycobacterium tuberculosis Biochemical And Biophysical Research Communications, Jan 2011 DOI: 10.1016/j.bbrc.2011.01.027
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Extending the usability of the phasing power of diselenide bonds: SeCys SAD phasing of CsgC using a non-auxotrophic strain Acta Crystallographica Section D, 67 Jan 2011 DOI: 10.1107/S0907444910042022
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
A processed noncoding RNA regulates an altruistic bacterial antiviral system Nature Structural & Molecular Biology, 18 (2) Jan 2011 DOI: 10.1038/nsmb.1981
Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain Journal Of Biological Chemistry, 286 (5) Jan 2011 DOI: 10.1074/jbc.M110.188193
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA Organic & Biomolecular Chemistry, 9 (5) Jan 2011 DOI: 10.1039/c0ob00886a
Journal Paper I04-Macromolecular Crystallography
- J. E. Mcgeehan, N. J. Ball, S. D. Streeter, S.-J. Thresh, G. G. Kneale, "Recognition of dual symmetry by the controller protein C.Esp1396I based on the structure of the transcriptional activation complex", Nucleic Acids Research, 40 (9), 4158-4167. (2011), DOI: 10.1093/nar/gkr1250
- Chao Yu, Max Crispin, Andreas F.-P. Sonnen, David J. Harvey, Veronica T. Chang, Christopher N. Scanlan, David I. Stuart, Robert J. C. Gilbert, Simon J. Davis, Edward J. Evans, "Use of the gamma-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells.", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67, 785-789 (2011), DOI: 10.1107/S1744309111017672
- James E. H. Day, Swee Y. Sharp, Martin G. Rowlands, Wynne Aherne, Angela Hayes, Florence I. Raynaud, William Lewis, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, Paul Workman, Christopher J. Moody, "Targeting the Hsp90 molecular chaperone with novel macrolactams. synthesis, structural, binding, and cellular studies", Acs Chemical Biology, 6 (12), 1339 - 1347 (2011), DOI: 10.1021/cb200196e
- Charlotte H. Coles, Yingjie Shen, Alan P. Tenney, Christian Siebold, Geoffrey C. Sutton, Weixian Lu, John T. Gallagher, E. Yvonne Jones, John G. Flanagan, Alexandru Aricescu, "Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension", Science, 332 (2011), DOI: 10.1126/science.1200840
- Martin A. M. Reijns, Doryen Bubeck, Lucien C. D. Gibson, Stephen C. Graham, George S. Baillie, E. Yvonne Jones, Andrew P. Jackson, "The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease", Journal Of Biological Chemistry, 286 (12), 10530-10539 (2011), DOI: 10.1074/jbc.M110.177394
- Nia L. Marrott, Jacqueline J. T. Marshall, Dmitri I. Svergun, Susan J. Crennell, David W. Hough, Michael J. Danson, Jean M. H. Van Den Elsen, "The catalytic core of an archaeal 2-oxoacid dehydrogenase multienzyme complex is a 42-mer protein assembly", Febs Journal (2011), DOI: 10.1111/j.1742-4658.2011.08461.x
- Joseph A. Newman, Lorraine Hewitt, Cecilia Rodriguez, Alexandra S. Solovyova, Colin R. Harwood, Richard J. Lewis, "Dissection of the network of interactions that links RNA processing with glycolysis in the Bacillus subtilis degradosome", Journal Of Molecular Biology (2011), DOI: 10.1016/j.jmb.2011.12.024
- Doryen Bubeck, Martin A. M. Reijns, Stephen C. Graham, Katy R. Astell, E. Yvonne Jones, Andrew P. Jackson, "PCNA directs type 2 RNase H activity on DNA replication and repair substrates", Nucleic Acids Research, 39 (9), 3652-3666 (2011), DOI: 10.1093/nar/gkq980
- Mary D. Holdom, Anna M. Davies, Joanne E. Nettleship, Sarah C. Bagby, Balvinder Dhaliwal, Enrico Girardi, James Hunt, Hannah J. Gould, Andrew J Beavil, James M. Mcdonnell, Ray J. Owens, Brian J. Sutton, "Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor Fc(Epsilon)RI", Nature Structural & Molecular Biology, 18 (5) (2011), DOI: 10.1038/nsmb.2044
- Roisin M. Mcmahon, Lone Friis, Christian Siebold, Manuel A Friese, Lars Fugger, E. Yvonne Jones, "Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis.", Acta Crystallographica Section D Biological Crystallography, 67 (5), 447-454 (2011), DOI: 10.1107/S0907444911007888
- Chao Yu, Andreas F.-P. Sonnen, Roger George, Benoit H. Dessailly, Loren J. Stagg, Edward J. Evans, Christine A. Orengo, David I. Stuart, John E. Ladbury, Shinji Ikemizu, Robert J. C. Gilbert, Simon J. Davis, "Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering", Journal Of Biological Chemistry, 286, 6685-6696. (2011), DOI: 10.1074/jbc.M110.182394
- Elena Seiradake, Charlotte H. Coles, Pavel V Perestenko, Karl Harlos, Robert A. J. Mcilhinney, E. Yvonne Jones, Alexandru Radu Aricescu, "Structural basis for cell surface patterning through NetrinG-NGL interactions", The Embo Journal, 30 (21), 4479 - 4488 (2011), DOI: 10.1038/emboj.2011.346
- Martin C. Moncrieffe, Maria-Jose Fernandez, Dieter Spiteller, Hiroyoshi Matsumura, Nicholas J. Gay, Ben F. Luisi, Peter F. Leadlay, "Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII", Journal Of Molecular Biology (2011), DOI: 10.1016/j.jmb.2011.10.036
- A. Cruz-Migoni, G. M. Hautbergue, P. J. Artymiuk, P. J. Baker, M. Bokori-Brown, C.-T. Chang, M. J. Dickman, A. Essex-Lopresti, S. V. Harding, N. M. Mahadi, L. E. Marshall, G. Mobbs, R. Mohamed, S. Nathan, S. A. Ngugi, C. Ong, W. F. Ooi, L. J. Partridge, H. L. Phillips, M. F. Raih, S. Ruzheinikov, M. Sarkar-Tyson, S. E. Sedelnikova, S. J. Smither, P. Tan, R. W. Titball, S. A. Wilson, D. W. Rice, "A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A", Science, 334, 821 - 824 (2011), DOI: 10.1126/science.1211915
- Thomas C. Eadsforth, Scott Cameron, William N. Hunter, "The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target", Molecular And Biochemical Parasitology (2011), DOI: 10.1016/j.molbiopara.2011.11.004
- Karen A. Nolan, Mark Dunstan, Mary C. Caraher, Katherine A. Scott, David Leys, Ian J. Stratford, "In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF B signalling", Molecular Cancer Therapeutics (2011), DOI: 10.1158/1535-7163.MCT-11-0543
- Alexandre R. Gingras, Umakhanth Venkatraman Girija, Anthony H. Keeble, Roshni Panchal, Daniel A. Mitchell, Peter C. E. Moody, Russell Wallis, "Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation", Structure, 19 (11), 1635 - 1643 (2011), DOI: 10.1016/j.str.2011.08.014
- Eviata Najan, Andreas Christian Joerger, "Structure and kinetic stability of the p63 tetramerization domain", Journal Of Molecular Biology (2011), DOI: 10.1016/j.jmb.2011.11.007
- Geoffrey Masuyer, Talat Jabeen, Christopher T. Öberg, Hakon Leffler, Ulf J. Nilsson, K. Ravi Acharya, "Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor", Febs Journal (2011), DOI: 10.1111/j.1742-4658.2011.08414.x
- David C. Goldstone, Valerie Ennis-Adeniran, Joseph J. Hedden, Harriet C. T. Groom, Gillian I. Rice, Evangelos Papagrigoriou, Phil A. Walker, Geoff Kelly, Lesley F. Haire, Melvyn W. Yap, Luiz Pedro S. De Carvalho, Jonathan P. Stoye, Yanick J. Crow, Ian A. Taylor, Michelle Webb, "HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase", Nature (2011), DOI: 10.1038/nature10623
- Sharon Miller, Daniela Sahlender, Stephen C. Graham, Stefan Honing, Margaret S. Robinson, Andrew A. Peden, David J. Owen, "The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM", Cell, 147 (5), 1118 - 1131 (2011), DOI: 10.1016/j.cell.2011.10.038
- Yu Hang Fong, Ho Chun Wong, Chi Pang Chuck, Yu Wai Chen, Hongzhe Sun, Kam-Bo Wong, "Assembly of the preactivation complex for urease maturation in Helicobacter pylori: crystal structure of the UreF/UreH complex", Journal Of Biological Chemistry, 286 (2011), DOI: 10.1074/jbc.M111.296830
- Paul R. Elliott, Han Liu, Martyna W. Pastok, Guenter J. Grossmann, Daniel J. Rigden, Michael J. Clague, Sylvie Urbé, Igor L. Barsukov, "Structural variability of the ubiquitin specific protease DUSP-UBL double domains", Febs Letters (2011), DOI: 10.1016/j.febslet.2011.09.040
- Zhenbo Cao, Timothy J. Tavender, Aleksander W. Roszak, Richard J. Cogdell, Neil J. Bulleid, "Crystal structure of reduced and of oxidized peroxiredoxin IV reveals a stable oxidized decamer and a non disulfide-bonded intermediate in the catalytic cycle", Journal Of Biological Chemistry (2011), DOI: 10.1074/jbc.M111.298810
- Nathan Zaccai, Bertie Chi, Andrew Thomson, Aimee L Boyle, Gail J Bartlett, Marc Bruning, Noah Linden, Richard B Sessions, Paula J Booth, Leo Brady, Derek N Woolfson, "A de novo peptide hexamer with a mutable channel", Nature Chemical Biology, 7 (12), 935 - 941 (2011), DOI: 10.1038/nchembio.692
- Qian Wu, Takashi Ochi, Dijana Matak‑vinkovic, Carol v. Robinson, Dimitri y. Chirgadze, Tom l. Blundell, "Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions", Biochemical Society Transactions, 39 (5), 1387 - 1392 (2011), DOI: 10.1042/BST0391387
- [Conference Paper] J. P. Sutter, S. Alcock, K. Sawhney, "Ex situ and in situ methods of inspecting and optimizing adaptive bimorph mirrors", Diamond Light Source Proceedings, 1 (2011), DOI: 10.1017/S2044820110000225
- Joseph A. Newman, Lorraine Hewitt, Cecilia Rodrigues, Alexandra Solovyova, Colin R. Harwood, Richard J. Lewis, "Unusual, dual endo- and exonuclease activity in the degradosome explained by crystal structure analysis of RNase J1", Structure, 19 (9), 1241 - 1251 (2011), DOI: 10.1016/j.str.2011.06.017
- Mark S. Dunstan, John Barnes, Matthew Humphries, Roger C. Whitehead, Richard A. Bryce, David Leys, Ian J. Stratford, Karen A. Nolan, "Novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2): crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones", Journal Of Medicinal Chemistry, 54 (19) (2011), DOI: 10.1021/jm200416e
- Massayuki Yamasaki, Timothy J. Sendall, Mary C. Pearce, James C. Whisstock, James A. Huntington, "Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer", Embo Reports (2011), DOI: 10.1038/embor.2011.171
- Dea Slade, Mark S. Dunstan, Eva Barkauskaite, Ria Weston, Pierre Lafite, Neil Dixon, Marijan Ahel, David Leys, Ivan Ahel, "The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase", Nature, 477, 616 - 620 (2011), DOI: 10.1038/nature10404
- Daniel A. East, Duncan Sousa, Stephen R. Martin, Thomas A. Edwards, William Lehman, Daniel P. Mulvihill, "Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin", Biochemical Journal, 438 (2), 265 - 273 (2011), DOI: 10.1042/BJ20101316
- Yoshikazu Kawai, Jon Marles-Wright, Robert M. Cleverley, Robyn Emmins, Shu Ishikawa, Masayoshi Kuwano, Nadja Heinz, Nhat Khai Bui, Christopher N. Hoyland, Naotake Ogasawara, Rick Lewis, Waldemar Vollmer, Richard A. Daniel, Jeff Errington, "A widespread family of bacterial cell wall assembly proteins", The Embo Journal (2011), DOI: 10.1038/emboj.2011.358
- Timo Heikkila, Edward Wheatley, Diane Crighton, Ewald Schroder, Alexandra Boakes, Sarah J. Kaye, Mokdad Mezna, Leon Pang, Mathew Rushbrooke, Andrew Turnbull, Michael F. Olson, "Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion", Plos One, 6 (9) (2011), DOI: 10.1371/journal.pone.0024825
- [Book Chapter] Muhammad Saleem, Jeremy Moore, Jeremy Derrick, "Expression, purification and crystallization of Neisserial outer membrane proteins" (2011), DOI: 10.1007/978-1-61779-346-2_6
- Antonio Ariza, Jens M. Eklof, Oliver Spadiut, Wendy A. Offen, Shirley M. Roberts, Werner Besenmatter, Esben P. Friis, Michael Skjot, Keith S. Wilson, Harry Brumer, Gideon Davies, "Structure and activity of Paenibacillus polymyxa xyloglucanase from glycoside hydrolase family 44", Journal Of Biological Chemistry, 286 (39), 33890 - 33900 (2011), DOI: 10.1074/jbc.M111.262345
- Susana Goncalves, Ana M. Esteves, Helena Santos, Nuno Borges, Pedro M. Matias, "The three-dimensional structure of mannosyl-3-phosphoglycerate phosphatase from Thermus thermophilus HB27: a new member of the Haloalkanoic Acid Dehalogenase superfamily", Biochemistry (2011), DOI: 10.1021/bi201171h
- Jennifer D. Artz, Amy K. Wernimont, Abdellah Allali-Hassani, Yong Zhao, Mehrnaz Amani, Yu-Hui Lin, Guillermo Senisterra, Gregory A. Wasney, Oleg Fedorov, Oliver King, Annette Roos, Vlad V. Lunin, Wei Qiu, Patrick Finerty, Ashley Hutchinson, Irene Chau, Frank Von Delft, Farrell Mackenzie, Jocelyne Lew, Ivona Kozieradzki, "The Cryptosporidium parvum kinome", Bmc Genomics, 12, 478 (2011), DOI: 10.1186/1471-2164-12-478
- Emília Antolikova, Lenka Zakova, Johan P. Turkenburg, Christopher J. Watson, Ivona Hanclova, Miloslav Sanda, Alan Cooper, Tomas Kraus, A. Marek Brzozowski, Jiri Jiracek, "Non-equivalent role of inter- and intra-molecular hydrogen bonds in the insulin dimer interface", Journal Of Biological Chemistry (2011), DOI: 10.1074/jbc.M111.265249
- Karl Syson, Clare E. M. Stevenson, Martin Rejzek, Shirley A. Fairhurst, Alap Nair, Celia J. Bruton, Robert A. Field, Keith F. Chater, Stephen Bornemann, David M. Lawson, "Structure of a Streptomyces maltosyltransferase GlgE: a homologue of a genetically validated anti-tuberculosis target", Journal Of Biological Chemistry (2011), DOI: 10.1074/jbc.M111.279315
- Laurence S. Boutemy, Stuart R. F. King, Joe Win, Richard K. Hughes, Thomas A. Clarke, Tharin M. A. Blumenschein, Sophien Kamoun, Mark J. Banfield, "Structures of Phytophthora RXLR effector proteins: a conserved but adaptable fold underpins functional diversity", Journal Of Biological Chemistry (2011), DOI: 10.1074/jbc.M111.262303
- Stephen Harper, Tabot M. D. Besong, Jonas Emsley, David J. Scott, Ingrid Dreveny, "Structure of the USP15 N-terminal domains: a β-hairpin mediates close association between the DUSP and UBL domains", Biochemistry, 50 (37), 7995 - 8004 (2011), DOI: 10.1021/bi200726e
- Tung B. K. Le, Maria A. Schumacher, Rcihard G. Brennan, Mark J. Buttner, David M. Lawson, "The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding", Nucleic Acids Research (2011), DOI: 10.1093/nar/gkr640
- Christopher Agnew, Elena Borodina, Nathan Zaccai, Rebecca Conners, Nick Burton, J. A. Vicary, David Cole, Massimo Antognozzi, Mumtaz Virji, R. Leo Brady, "Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding", Proceedings Of The National Academy Of Sciences (2011), DOI: 10.1073/pnas.1106341108
- Pietro Roversi, Steven Johnson, Joseph J. E. Caesar, Florence Mclean, Kirstin J. Leath, Stefanos A. Tsiftsoglou, B. Paul Morgan, Claire L. Harris, Robert B. Sim, Susan M. Lea, "Structures of the rat complement regulator CrrY", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (7), 739 - 743 (2011), DOI: 10.1107/S1744309111016551
- Ilka Müller, Marieke B. A. C. Lamers, Alison J. Ritchie, Celia Dominguez, Ignacio Munoz, Alex Kiselyov, "Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation", Bioorganic & Medicinal Chemistry Letters (2011), DOI: 10.1016/j.bmcl.2011.07.041
- Fatima Fonseca, Elizabeth H. C. Bromley, Maria José Saavedra, António Correia, James Spencer, "Crystal structure of Serratia fonticola Sfh-I: activation of the nucleophile in mono-zinc metallo-β-lactamases", Journal Of Molecular Biology (2011), DOI: 10.1016/j.jmb.2011.06.043
- Jonathan M. Kirby, Nethaji Thiyagarajan, April Roberts, Clifford Shone, K. Ravi Acharya, "Expression, purification, crystallization and preliminary crystallographic analysis of a putative Clostridium difficile surface protein Cwp19", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (7), 762 - 767 (2011), DOI: 10.1107/S1744309111016770
- Tatas H. P. Brotosudarmo, Aaron M. Collins, Andrew Gall, Aleksander W. Roszak, Alastair T. Gardiner, Robert E. Blankenship, Richard J. Cogdell, "The light intensity at which cells are grown controls the type of peripheral light-harvesting complexes that are assembled in a purple photosynthetic bacterium", Biochemical Journal (2011), DOI: 10.1042/BJ20110575
- Stefan H. Millson, Chun-Song Chua, S. Mark Roe, Sigrun Polier, Svetlana Solovieva, Laurence H. Pearl, Tiow-Suan Sim, Chrisostomos Prodromou, Peter W. Piper, "Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90", The Faseb Journal (2011), DOI: 10.1096/fj.11-188821
- Rasheduzzaman Chowdhury, Emily Flashman, Jasmin Mecinoviæ, Holger B. Kramer, Benedikt M. Kessler, Yves M. Frapart, Jean-Luc Boucher, Ian Clifton, Michael Mcdonough, Christopher J. Schofield, "Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)", Journal Of Molecular Biology, 410 (2), 268 - 279 (2011), DOI: 10.1016/j.jmb.2011.04.075
- Karthik S. Paithankar, Henning O. Sørensen, Jonathan P. Wright, Søren Schmidt, Henning F. Poulsen, Elspeth F. Garman, "Simultaneous X-ray diffraction from multiple single crystals of macromolecules", Acta Crystallographica Section D Biological Crystallography, 67 (7), 608 - 618 (2011), DOI: 10.1107/S0907444911015617
- Li Zhang, Louise Fairall, Benjamin Goult, Anna C. Calkin, Cynthia Hong, Chris Millard, Peter Tontonoz, John W. R. Schwabe, "The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor", Genes & Development, 25 (12), 1262 - 1274 (2011), DOI: 10.1101/gad.2056211
- A. Kale, C. Phansopa, C. Suwannachart, C. J. Craven, J. B. Rafferty, D. J. Kelly, "The virulence factor PEB4 (Cj0596) and the periplasmic protein Cj1289 are two structurally related SurA-like chaperones in the human pathogen Campylobacter jejuni", Journal Of Biological Chemistry, 286 (24), 21254 - 21265 (2011), DOI: 10.1074/jbc.M111.220442
- Emmanuel Saridakis, Sahir Khurshid, Lata Govada, Quan Phan, Daniel Hawkins, Gregg V. Crichlow, Elias Lolis, Subrayal M. Reddy, Naomi E. Chayen, "Protein crystallization facilitated by molecularly imprinted polymers", Proceedings Of The National Academy Of Sciences (2011), DOI: 10.1073/pnas.1016539108
- [Conference Paper] Richard Cogdell, "Mapping lipid and detergent molecules at the surface of membrane proteins" (2011), DOI: 10.1042/BST0390775
- [Thesis] Gabriela Baeza, "X-ray crystallographic structure of the murine norovirus protease at 1.66 Å resolution and functional studies of the β-ribbon" (2011)
- Eviatar Natan, Cetin Baloglu, Kevin Pagel, Stefan M. V. Freund, Nina Morgner, Carol V. Robinson, Alan R. Fersht, Andreas C. Joerger, "Interaction of the p53 DNA-binding domain with its N-terminal extension modulates the stability of the p53 tetramer", Journal Of Molecular Biology, 409 (3), 358 - 368 (2011), DOI: 10.1016/j.jmb.2011.03.047
- Marcio V. B. Dias, William C. Snee, Karen M. Bromfield, Richard J. Payne, Satheesh K. Palaninathan, Alessio Ciulli, Nigel I. Howard, Chris Abell, James C. Sacchettini, Tom l. Blundell, "Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis", Biochemical Journal, 436 (3), 729 - 739 (2011), DOI: 10.1042/BJ20110002
- M. A. S. Correia, K. Mazumder, J. L. A. Bras, S. J. Firbank, Y. Zhu, R. J. Lewis, W. S. York, C. M. G. A. Fontes, H. J. Gilbert, "Structure and function of an arabinoxylan-specific xylanase", Journal Of Biological Chemistry, 286 (25), 22510 - 22520 (2011), DOI: 10.1074/jbc.M110.217315
- Jon Marles-Wright, Richard J. Lewis, "The structure of a D-lyxose isomerase from the σB regulon of Bacillus subtilis", Proteins: Structure, Function, And Bioinformatics, 79, 2015 - 2019 (2011), DOI: 10.1002/prot.23028
- James A. Cracknell, Thomas P. Mcnamara, Edward D. Lowe, Christopher F. Blanford, "Bilirubin oxidase from Myrothecium verrucaria: X-ray determination of the complete crystal structure and a rational surface modification for enhanced electrocatalytic O2 reduction", Dalton Transactions, 40 (25), 40 (25) (2011), DOI: 10.1039/C0DT01403F
- Daniel P. Ryan, Ramasubramanian Sundaramoorthy, David Martin, Vijender Singh, Tom Owen-Hughes, "The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains", The Embo Journal (2011), DOI: 10.1038/emboj.2011.166
- Glyn Hemsworth, Olga V. Moroz, Mark J. Fogg, Benjamin Scott, Cristina Bosch-Navarrete, Dolores Gonzalez-Pacanowska, Keith S. Wilson, "The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine", Journal Of Biological Chemistry, 286 (18), 16470 - 16481 (2011), DOI: 10.1074/jbc.M111.224873
- Tobias Krojer, Frank Von Delft, "Assessment of radiation damage behaviour in a large collection of empirically optimized datasets highlights the importance of unmeasured complicating effects", Journal Of Synchrotron Radiation, 18 (3), 387-397 (2011), DOI: 10.1107/S0909049511008235
- Rasheduzzaman Chowdhury, Kar Kheng Yeoh, Ya-Min Tian, Lars Hillringhaus, Eleanor Bagg, Nathan R. Rose, Ivanhoe K. H. Leung, Xuan S. Li, Esther C. Y. Woon, Ming Yang, Michael A. Mcdonough, Oliver N. King, Ian J. Clifton, Robert J. Klose, Timothy D. W. Claridge, Peter J. Ratcliffe, Christopher J. Schofield, Akane Kawamura, "The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases", Embo Reports, 12 (5), 463-469 (2011), DOI: 10.1038/embor.2011.43
- Peter Cherepanov, Goedele N. Maertens, Stephen Hare, "Structural insights into the retroviral DNA integration apparatus", Current Opinion In Structural Biology, 21 (2), 249 - 256 (2011), DOI: 10.1016/j.sbi.2010.12.005
- Jean M. H. Van Den Elsen, David E. Isenman, "A crystal structure of the complex between human complement receptor 2 and its ligand C3d", Science, 332, 608-611 (2011), DOI: 10.1126/science.1201954
- Paula S. Salgado, Robert Yan, Fiona Rowan, Ernesto Cota, "Expression, crystallization and preliminary X-ray data analysis of NT-ALS9, a fungal adhesin from Candida albicans", Acta Crystallographica Section F Structural Biology And Crystallization Communications (2011), DOI: 10.1107/S1744309111003460
- Thomas A. Edwards, Andrew J. Wilson, "Helix-mediated protein-protein interactions as targets for intervention using foldamers", Amino Acids (2011), DOI: 10.1007/s00726-011-0880-8
- Fiona Cuskin, Alexandra Solovyova, Rick Lewis, Paul Race, "Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67(4), 464-466 (2011), DOI: 10.1107/S1744309111003484
- Gavin W. Collie, Silvia Sparapani , Gary N. Parkinson, Stephen Neidle, "Structural basis of telomeric RNA quadruplex−acridine ligand recognition", Journal Of The American Chemical Society, 133 (8) (2011), DOI: 10.1021/ja109767y
- Ming Yang, Rasheduzzaman Chowdhury, Wei Ge, Refaat Hamed, Michael Mcdonough, Timothy Claridge, Benedikt Kessler, Matthew Cockman, Peter Ratcliffe, Christopher Schofield, "Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains", Febs Letters, 278 (7), 1086-1097 (2011), DOI: 10.1111/j.1742-4658.2011.08022.x
- Mohd Akif, Sylva L. Schwager, Colin S. Anthony, Bertrand Czarny, Fabrice Beau, Edward Sturrock, K. Ravi Acharya, "Novel mechanism of inhibition of human Angiotensin-I converting enzyme (ACE) by a highly specific phosphinic tripeptide", Biochemical Journal (2011), DOI: 10.1042/BJ20102123
- Tung B. K. Le, Clare E. M. Stevenson, Hans-Peter Fiedler, Anthony Maxwell, David M. Lawson, Mark J. Buttner, "Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression", Journal Of Molecular Biology (2011), DOI: 10.1016/j.jmb.2011.02.035
- Allan Pang, Martin J. Warren, Richard W. Pickersgill, "Structure of PduT, a trimeric bacterial microcompartment protein with a 4Fe-4S cluster-binding site", Acta Crystallographica Section D-Structural Biology, 67 (2), 91-96 (2011), DOI: 10.1107/S0907444910050201
- Hugh P. Morgan, Christoph Q. Schmidt, Mara Guariento, Bärbel S. Blaum, Dominic Gillespie, Andrew P. Herbert, David Kavanagh, Haydyn D. T. Mertens, Dmitri I. Svergun, Conny M. Johansson, Dušan Uhrín, Paul N. Barlow, Jonathan P. Hannan, "Structural basis for engagement by complement factor H of C3b on a self surface", Nature Structural & Molecular Biology, 18 (4), 463 - 470 (2011), DOI: 10.1038/nsmb.2018
- Keri Barrack, Lindsay B. Tulloch, Lynsey-Anne Burke, Paul Fyfe, William Hunter, "Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (1), 33-37 (2011), DOI: 10.1107/S174430911004724X
- Abdelnasser El Ghazouani, Arnaud Basle, Susan J. Firbank, Charles W. Knapp, Joe Gray, David W. Graham, Christopher Dennisson, "Copper-binding properties and structures of methanobactins from Methylosinus trichosporium OB3b", Inorganic Chemistry, 50(4), 1378-1391 (2011), DOI: 10.1021/ic101965j
- Xun Cai, Rui Wang, Alain Filloux, Gabriel Waksman, Goyu Meng, "Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones", Plos One (2011), DOI: 10.1371/journal.pone.0016583
- Philip Simister, Nick Burton, Leo Brady, "Phosphotyrosine recognition by the Raf kinase inhibitor protein", Onco Therapeutics, 2(1), 59-70 (2011), DOI: 10.1615/ForumImmunDisTher.v2.i1.70
- Yi Yang, James A. Garnett, Stephen Matthews, "Crystallization and initial crystallographic analysis of AafA: the major adhesive subunit of the enteroaggregative Escherichia coli AAF/II pilus", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 67 (4), 454 - 456 (2011), DOI: 10.1107/S1744309111001412
- Celia V. Romao, Dimitrios Ladakis, Susana A. L. Lobo, Maria A. Carrondo, Amanda A. Brindley, Evelyne Deery, Pedro M. Matias, Richard W. Pickersgill, Ligia M. Saraiva, Mark J. Warren, "Evolution in a family of chelatases facilitated by the introduction of active site asymmetry and protein oligomerization", Proceedings Of The National Academy Of Sciences, 108 (1), 97 - 102 (2011), DOI: 10.1073/pnas.1014298108
- Andrea Gumiero, Clive L. Metcalfe, Emma Raven, Peter C. E. Moody, Arwen Pearson, "Nature of the ferryl heme in compounds I and II", Journal Of Biological Chemistry, 286, 1260-1268. (2011), DOI: 10.1074/jbc.M110.183483
- Jasmeen Oberoi, Louise Fairall, Peter J. Watson, Ji-Chun Yang, Zsolt Czimmerer, Thorsten Kampmann, Ben Goult, Jacquie Greenwood, John T. Gooch, Bettina C. Kallenburger, Laszlo Nagy, David Neuhaus, John W. R. Schwabe, "Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery", Nature Structural & Molecular Biology, 18 (2), 177 - 184 (2011), DOI: 10.1038/nsmb.1983
- Alicja K. Antonczak, Zuzana Simova, Isaac T. Yonemoto, Matthias Bochtler, Anna Piasecka, Honorata Czapinska, Andrea Brancale, Eric M. Tippmann, "Importance of single molecular determinants in the fidelity of expanded genetic codes", Proceedings Of The National Academy Of Sciences, 108 (4), 1320 - 1325 (2011), DOI: 10.1073/pnas.1012276108
- Wen-Jun Gui, Shi-Qiang Lin, Yuan-Yuan Chen, Xian-En Zhang, Li-Jun Bi, Tao Jiang, "Crystal structure of DNA polymerase III β sliding clamp from Mycobacterium tuberculosis", Biochemical And Biophysical Research Communications (2011), DOI: 10.1016/j.bbrc.2011.01.027
- Paula Salgado, Jonathan Taylor, Ernesto Cota, Steve J. Matthews, "Extending the usability of the phasing power of diselenide bonds: SeCys SAD phasing of CsgC using a non-auxotrophic strain", Acta Crystallographica Section D, 67, 8-13 (2011), DOI: 10.1107/S0907444910042022
- Tim R. Blower, Xue-Yuan Pei, Francesca L. Short, Peter C. Fineran, David P. Humphreys, Ben F. Luisi, George P. C. Salmond, "A processed noncoding RNA regulates an altruistic bacterial antiviral system", Nature Structural & Molecular Biology, 18 (2), 185190 (2011), DOI: 10.1038/nsmb.1981
- T. Tanaka, H. Sewell, S. Waters, S. E. V. Phillips, T. H. Rabbitts, "Single domain intracellular antibodies from diverse libraries: emphasizing dual functions of LMO2 protein interactions using a single VH domain", Journal Of Biological Chemistry, 286 (5), 3707 - 3716 (2011), DOI: 10.1074/jbc.M110.188193
- Nancy H. Campbell, Daniel L. Smith, Anthony P. Reszka, Stephen Neidle, David O'Hagan, "Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA", Organic & Biomolecular Chemistry, 9 (5), 3300-3315 (2011), DOI: 10.1039/c0ob00886a
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