Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
63 items found for 2010 [total: 2283]
The crystal structure of the ubiquitin-like (UbL) domain of human homologue A of Rad23 (hHR23A) protein Protein Engineering Design And Selection, 24 Dec 2010 DOI: 10.1093/protein/gzq084
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex. Plos Biology, 8 (2) Dec 2010 DOI: 10.1371/journal.pbio.1000306
Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis Acta Crystallographica Section F Structural Biology And Crystallization Communications, 66 (10) Dec 2010 DOI: 10.1107/S1744309110039679
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen Journal Of Biological Chemistry, 285 (49) Dec 2010 DOI: 10.1074/jbc.M110.164293
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding Protein Science, 19 (12) Dec 2010 DOI: 10.1002/pro.507
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis Protein And Cell, 1 (11) Dec 2010 DOI: 10.1007/s13238-010-0132-9
Journal Paper I04-Macromolecular Crystallography
Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF Proceedings Of The National Academy Of Sciences, 107 (50) Dec 2010 DOI: 10.1073/pnas.1010780107
Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING domains (CHFR) Journal Of Biological Chemistry, 285 (50) Dec 2010 DOI: 10.1074/jbc.M110.159855
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d Molecular Immunology, Nov 2010 DOI: 10.1016/j.molimm.2010.09.017
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors Plos One, Nov 2010 DOI: 10.1371/journal.pone.0015535
Crystal structure of TtgV in complex with its DNA operator reveals a general model for cooperative DNA binding of tetrameric gene regulators Genes & Development, 24(22) Nov 2010 DOI: 10.1101/gad.603510
Journal Paper I04-Macromolecular Crystallography
Trapping of palindromic ligands within native transthyretin prevents amyloid formation Proceedings Of The National Academy Of Sciences, 107(47) Nov 2010 DOI: 10.1073/pnas.1008255107
Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization Journal Of Medicinal Chemistry, 53 (21) Nov 2010 DOI: 10.1021/jm1008727
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase corynebacterium glutamicum pimb' Journal Of Biological Chemistry, 285 (48) Nov 2010 DOI: 10.1074/jbc.M110.165407
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance Proceedings Of The National Academy Of Sciences, Oct 2010 DOI: 10.1073/pnas.1010246107
Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations Proceedings Of The National Academy Of Sciences, 107 (42) Oct 2010 DOI: 10.1073/pnas.1008206107
Journal Paper I04-Macromolecular Crystallography
Structural basis for retroviral intasome assembly and integrase inhibitor action Oct 2010
Magazine Article I02-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural insights into substrate specificity in variants of N-acetylneuraminic acid lyase produced by directed evolution Journal Of Molecular Biology, Sept 2010 DOI: 10.1016/j.jmb.2010.08.008
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structural and functional analysis of prehistoric lentiviruses uncovers an ancient molecular interface Cell Host & Microbe, 8 (3) Sept 2010 DOI: 10.1016/j.chom.2010.08.006
Journal Paper I04-Macromolecular Crystallography
The structural basis for catalysis and substrate specificity of a rhomboid protease The Embo Journal, Sept 2010 DOI: 10.1038/emboj.2010.243
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans Acta Crystallographica Section F Structural Biology And Crystallization Communications, 66 (9) Sept 2010 DOI: 10.1107/S1744309110029714
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
A disulfide driven domain swap switches off the activity of Shigella IpaH9.8 E3 ligase Febs Letters, Sept 2010 DOI: 10.1016/j.febslet.2010.09.006
Journal Paper I04-Macromolecular Crystallography
The structure of the FnIII Tandem A77-A78 points to a periodically conserved architecture in the myosin-binding region of titin Journal Of Molecular Biology, 401 (5) Sept 2010 DOI: 10.1016/j.jmb.2010.06.011
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
The structure of the genomic Bacillus subtilis dUTPase: novel features in the Phe-lid Acta Crystallographica Section D Biological Crystallography, 66 (9) Sept 2010 DOI: 10.1107/S0907444910026272
Journal Paper I04-Macromolecular Crystallography
Comparative structural analysis of human DEAD-box RNA helicases Plos One, 5 Sept 2010 DOI: 10.1371/journal.pone.0012791
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes Chemistry & Biology, 17 (9) Sept 2010 DOI: 10.1016/j.chembiol.2010.07.006
Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery Acta Crystallographica Section D Biological Crystallography, 66 (8) Aug 2010 DOI: 10.1107/S0907444910020081
Crystal structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa Journal Of Structural Biology, 172(3) Aug 2010 DOI: 10.1016/j.jsb.2010.07.012
Journal Paper I04-Macromolecular Crystallography
Structural determination of functional domains in Early B-cell Factor (EBF) family of transcription factors reveals similarities to rel DNA binding proteins and a novel dimerisation motif. Journal Of Biological Chemistry, 285(34) Aug 2010 DOI: 10.1074/jbc.C110.150482
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6 Journal Of Molecular Biology, 401 (2) Aug 2010 DOI: 10.1016/j.jmb.2010.05.054
Journal Paper I04-Macromolecular Crystallography
Structural studies of ligand recognition by the collectins hSP-D, CL-46 and conglutinin Jul 2010
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography
The K5 lyase KflA combines a viral tail spike structure with a bacterial polysaccharide lyase mechanism Journal Of Biological Chemistry, 285 (31) Jul 2010 DOI: 10.1074/jbc.M110.127571
Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations Cell, 141 (7) June 2010 DOI: 10.1016/j.cell.2010.05.005
Journal Paper I04-Macromolecular Crystallography
Probing the interaction of archaeal DNA polymerases with deaminated bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues Biochemistry, 49 (27) June 2010 DOI: 10.1021/bi100421r
Journal Paper I04-Macromolecular Crystallography
High-resolution crystal structures of Drosophila melanogaster angiotensin-converting enzyme in complex with novel inhibitors and antihypertensive drugs Journal Of Molecular Biology, 400 (3) May 2010 DOI: 10.1016/j.jmb.2010.05.024
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein essential for ribosome biogenesis Acta Crystallographica Section F Structural Biology And Crystallization Communications, 66 (5) May 2010 DOI: 10.1107/S1744309110011206
Journal Paper I04-Macromolecular Crystallography
Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide Bioorganic & Medicinal Chemistry, 18 (13) May 2010 DOI: 10.1016/j.bmc.2010.05.012
Journal Paper I04-Macromolecular Crystallography
Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations Nature Structural & Molecular Biology, 17 (6) May 2010 DOI: 10.1038/nsmb.1808
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure of the Rna15 RRM-RNA complex reveals the molecular basis of GU specificity in transcriptional 3'-end processing factors Nucleic Acids Research, May 2010 DOI: 10.1093/nar/gkq002
Crystal structure of a junction between two Z-DNA helices Proceedings Of The National Academy Of Sciences, 107 (20) May 2010 DOI: 10.1073/pnas.1003182107
Journal Paper I04-Macromolecular Crystallography
Co-factor-independent oxidases and oxygenases Applied Microbiology And Biotechnology, 86 (3) Apr 2010 DOI: 10.1007/s00253-010-2455-0
Journal Paper I04-Macromolecular Crystallography
Glutamate-haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3 Biochemical Journal, 427 (3) Apr 2010 DOI: 10.1042/BJ20091603
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Domain cross-talk during effector binding to the multidrug binding TTGR regulator Journal Of Biological Chemistry, 285(28) Apr 2010 DOI: 10.1074/jbc.M110.113282
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Targeting transthyretin - X-ray crystallography and rational drug design Amyloid, 17 (s1) Apr 2010 DOI: 10.3109/13506121003737419
Poster I04-Macromolecular Crystallography
Structure of the aliphatic sulfonate-binding protein SsuA from Escherichia coli Acta Crystallographica Section F Structural Biology And Crystallization Communications, 66 (4) Apr 2010 DOI: 10.1107/S1744309110006226
Journal Paper I04-Macromolecular Crystallography
Structural homology between the C-terminal domain of the PapC usher and its plug Journal Of Bacteriology, 192 (7) Apr 2010 DOI: 10.1128/JB.01677-09
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. Journal Of Biological Chemistry, 285 (17) Apr 2010 DOI: 10.1074/jbc.M109.050062
With phases: how two wrongs can sometimes make a right Acta Crystallographica Section D Biological Crystallography, 66 (4) Apr 2010 DOI: 10.1107/S0907444909048112
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Assembly of a 20-nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase Journal Of Molecular Biology, 396 (5) Mar 2010 DOI: 10.1016/j.jmb.2009.12.056
Journal Paper I04-Macromolecular Crystallography
An analysis of substrate binding interactions in the heme peroxidase enzymes Archives Of Biochemistry And Biophysics, 500 (1) Mar 2010 DOI: 10.1016/j.abb.2010.02.015
The crystal structure of unmodified tRNAPhe from Escherichia coli Nucleic Acids Research, 38 (12) Mar 2010 DOI: 10.1093/nar/gkq133
Structure and oligomerization of the PilC type IV pilus biogenesis protein from Thermus thermophilus Proteins: Structure, Function, And Bioinformatics, 78 (9) Mar 2010 DOI: 10.1002/prot.22720
Journal Paper I04-Macromolecular Crystallography
Structural analysis of Thermus thermophilus HB27 mannosyl-3-phosphoglycerate synthase provides evidence for a second catalytic metal ion and new insight into the retaining mechanism of glycosyltransferases Journal Of Biological Chemistry, Mar 2010 DOI: 10.1074/jbc.M109.095976
Fragment-based discovery and optimization of BACE1 inhibitors Bioorganic & Medicinal Chemistry Letters, 20 (17) Mar 2010 DOI: 10.1016/j.bmcl.2010.06.089
Journal Paper I04-Macromolecular Crystallography
The structure of the catalytic subunit FANCL of the Fanconi anemia core complex Nature Structural & Molecular Biology, 17 (3) Feb 2010 DOI: 10.1038/nsmb.1759
Journal Paper I04-Macromolecular Crystallography
Mutations in an avian IgY-Fc fragment reveal the locations of monocyte Fc receptor binding sites Developmental & Comparative Immunology, 34 (2) Feb 2010 DOI: 10.1016/j.dci.2009.08.012
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex Proceedings Of The National Academy Of Sciences, 107 (7) Feb 2010 DOI: 10.1073/pnas.0913736107
The use of novel organic gels and hydrogels in protein crystallization Journal Of Applied Crystallography, 43 Feb 2010 DOI: 10.1107/S0021889809051917
Journal Paper I04-Macromolecular Crystallography
The three-dimensional structure of [NiFeSe] hydrogenase from Desulfovibrio vulgaris Hildenborough: A hydrogenase without a bridging ligand in the active site in its oxidised, “as-isolated” state Journal Of Molecular Biology, Jan 2010 DOI: 10.1016/j.jmb.2009.12.013
Journal Paper I04-Macromolecular Crystallography
Biocatalysis with thermostable enzymes: structure and properties of a thermophilic 'ene'-reductase related to old yellow enzyme Chembiochem, 11 (2) Jan 2010 DOI: 10.1002/cbic.200900570
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Retroviral intasome assembly and inhibition of DNA strand transfer Nature, Jan 2010 DOI: 10.1038/nature08784
Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888 Biochemistry, Jan 2010 DOI: 10.1021/bi902079y
Journal Paper I04-Macromolecular Crystallography
Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the α/β-hydrolase fold Proceedings Of The National Academy Of Sciences, 107 (2) Jan 2010 DOI: 10.1073/pnas.0909033107
Journal Paper I04-Macromolecular Crystallography
- Y. W. Chen, T. Tajima, S. Agrawal, "The crystal structure of the ubiquitin-like (UbL) domain of human homologue A of Rad23 (hHR23A) protein", Protein Engineering Design And Selection, 24, 131 - 138 (2010), DOI: 10.1093/protein/gzq084
- Christian H Bell, Steven L Porter, Annabel Strawson, David I. Stuart, Judith P. Armitage, "Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex.", Plos Biology, 8 (2) (2010), DOI: 10.1371/journal.pbio.1000306
- Mads Gabrielsen, Caroline E. Zetterström, Dai Wang, Katherine Beckham, Mikael Elofsson, Neil W. Isaacs, Andrew J. Roe, "Expression, purification, crystallization and initial X-ray diffraction analysis of thiol peroxidase from Yersinia pseudotuberculosis", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 66 (10), 1606-1609 (2010), DOI: 10.1107/S1744309110039679
- Max D. Driscoll, Kirsty J. Mclean, Colin Levy, Nathalia Mast, Irina A Pikuleva, David Leys, Pierre Lafite, Stephen E. J. Rigby, Andrew W. Munro, "Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen", Journal Of Biological Chemistry, 285 (49), 38270-82 (2010), DOI: 10.1074/jbc.M110.164293
- Joel L. Kaar, Nicolas Basse, Andreas C. Joerger, Elaine Stephens, Trevor J. Rutherford, Alan R. Fersht, "Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding", Protein Science, 19 (12), 2267-2278 (2010), DOI: 10.1002/pro.507
- Chandrakala Basavannacharya, Paul R. Moody, Tulika Munshi, Nora Cronin, Nicholas Keep, Sanjib Bhakta, "Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis", Protein And Cell, 1 (11), 1011 - 1022 (2010), DOI: 10.1007/s13238-010-0132-9
- N. G. Housden, Justyna A. Wojdyla, Justyna Korczynska, I. Grishkovskaya, N. Kirkpatrick, Andrzej Marek Brzozowski, C. Kleanthous, "Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF", Proceedings Of The National Academy Of Sciences, 107 (50), 21412 - 21417 (2010), DOI: 10.1073/pnas.1010780107
- J. Oberoi, M. W. Richards, S. Crumpler, N. Brown, J. Blagg, R. Bayliss, "Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING domains (CHFR)", Journal Of Biological Chemistry, 285 (50), 39348 - 39358 (2010), DOI: 10.1074/jbc.M110.159855
- Elizabeth A. Clark, Susan Crennell, Abhisehk Upadhyay, Alexey V. Zozulya, Julia D. Mackay, Dmitri Svergun, Stefan Bagby, Jean M. H. Van Den Elsen, "A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d", Molecular Immunology (2010), DOI: 10.1016/j.molimm.2010.09.017
- Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R. Rose, Stanley S. Ng, Amy M. Quinn, Ganesha Rai, Bryan Mott, Paul Beswick, Robert Klose, Udo Oppermann, Ajit Jadhav, Tom Heightman, David J. Maloney, Christopher J. Schofield, Anton Simeonov, "Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors", Plos One (2010), DOI: 10.1371/journal.pone.0015535
- Duo Lu, Sandy Fillet, Cuixiang Meng, Yilmaz Alguel, Patrick Kloppsteck, Julien Bergeron, Tino Krell, Mari-Trini Gallegos, Juan Ramos, Xiaodong Zhang, "Crystal structure of TtgV in complex with its DNA operator reveals a general model for cooperative DNA binding of tetrameric gene regulators", Genes & Development, 24(22), 2556-2565 (2010), DOI: 10.1101/gad.603510
- Simon E. Kolstoe, Palma P. Mangione, Vittorio Bellotti, Graham W. Taylor, Glenys A. Tennent, Stéphanie Deroo, Angus J. Morrison, Alexander J. A. Cobb, Anthony Coyne, Margaret Mccammon, Timothy D. Warner, Jane Mitchell, Raj Gill, Martin D. Smith, Steven Ley, Carol V. Robinson, Stephen P. Wood, Mark B. Pepys, "Trapping of palindromic ligands within native transthyretin prevents amyloid formation", Proceedings Of The National Academy Of Sciences, 107(47), 20483-20488 (2010), DOI: 10.1073/pnas.1008255107
- Daniel K. Whelligan, Savade Solanki, Dawn Taylor, Douglas W. Thomson, Kwai-Ming J. Cheung, Kathy Boxall, Corine Mas-Droux, Caterina Barillari, Samantha Burns, Charles G. Grummitt, Ian Collins, Rob L. M. Van Montfort, G. Wynne Aherne, Richard Bayliss, Swen Hoelder, "Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization", Journal Of Medicinal Chemistry, 53 (21), 7682 - 7698 (2010), DOI: 10.1021/jm1008727
- S. M. Batt, T. Jabeen, A. K. Mishra, N. Veerapen, K. Krumbach, L. Eggeling, G. S. Besra, K. Futterer, "Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase corynebacterium glutamicum pimb'", Journal Of Biological Chemistry, 285 (48), 37741 - 37752 (2010), DOI: 10.1074/jbc.M110.165407
- Stephen Hare, Ann M. Vos, Reginald F. Clayton, Jan W. Thuring, Maxwell Cummings, Peter Cherepanov, "Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance", Proceedings Of The National Academy Of Sciences (2010), DOI: 10.1073/pnas.1010246107
- Heidi L. Schubert, Qianting Zhai, Virginie Sandrin, Debra M. Eckert, Mitla Garcia-Maya, Louise Saul, Wesley I. Sundquist, Roberto A. Steiner, Christopher P. Hill, "Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations", Proceedings Of The National Academy Of Sciences, 107 (42), 17951 - 17956 (2010), DOI: 10.1073/pnas.1008206107
- [Magazine Article] Peter Cherepanov, "Structural basis for retroviral intasome assembly and integrase inhibitor action" (2010)
- Ivan Campeotto, Amanda H. Bolt, Thomas Harman , Caitriona Dennis, Chi Hung Trinh, Simon Phillips, Adam Nelson, Alan Berry, Arwen Pearson, "Structural insights into substrate specificity in variants of N-acetylneuraminic acid lyase produced by directed evolution", Journal Of Molecular Biology (2010), DOI: 10.1016/j.jmb.2010.08.008
- David C. Goldstone, Melvyn W. Yap, Laura E. Robertson, Lesley F. Haire, William R. Taylor, Aris Katzourakis, Jonathan P. Stoye, Ian A. Taylor, "Structural and functional analysis of prehistoric lentiviruses uncovers an ancient molecular interface", Cell Host & Microbe, 8 (3), 248 - 259 (2010), DOI: 10.1016/j.chom.2010.08.006
- Kutti R. Vinothkumar, Kvido Strisovsky, Antonina Andreeva, Yonka Christova, Steven Verhelst, Matthew Freeman, "The structural basis for catalysis and substrate specificity of a rhomboid protease", The Embo Journal (2010), DOI: 10.1038/emboj.2010.243
- Keisuke Ito , Sohei Ito, Tatsuro Shimamura, Yasuaki Kawarasaki, Keiko Abe, Takumi Misaka, Takuya Kobayashi, So Iwata, "Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 66 (9), 1086-1088 (2010), DOI: 10.1107/S1744309110029714
- Arefeh Seyedarabi, James A. Sullivan, Chihiro Sasakawa, Richard W. Pickersgill, "A disulfide driven domain swap switches off the activity of Shigella IpaH9.8 E3 ligase", Febs Letters (2010), DOI: 10.1016/j.febslet.2010.09.006
- Olga Mayans, Rainer M. Bucher, Dmitri I. Svergun, Claudia Muhle-Goll, "The structure of the FnIII Tandem A77-A78 points to a periodically conserved architecture in the myosin-binding region of titin", Journal Of Molecular Biology, 401 (5), 843-53 (2010), DOI: 10.1016/j.jmb.2010.06.011
- Javier García-Nafría, Lynn Burchell, Mine Takezawa, Neil J. Rzechorzek, Mark J. Fogg, Keith S. Wilson, "The structure of the genomic Bacillus subtilis dUTPase: novel features in the Phe-lid", Acta Crystallographica Section D Biological Crystallography, 66 (9), 953-961 (2010), DOI: 10.1107/S0907444910026272
- Patrick Schütz, Tobias Karlberg, Susanne Van Den Berg, Ruairi Collins, Lari Lehtiö, Martin Högbom, Lovisa Holmberg-Schiavone, Wolfram Tempel, Hee-Won Park, Martin Hammarström, Martin Moche, Ann-Gerd Thorsell, Herwig Schüler, "Comparative structural analysis of human DEAD-box RNA helicases", Plos One, 5 (2010), DOI: 10.1371/journal.pone.0012791
- Matthew S. Macauley, Yuan He, Tracey M. Gloster, Keith A. Stubbs, Gideon J. Davies, David J. Vocadlo, "Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes", Chemistry & Biology, 17 (9), 937 - 948 (2010), DOI: 10.1016/j.chembiol.2010.07.006
- Paul K. Fyfe, Alice Dawson, Marie-Theres Hutchison, Scott Cameron, William N. Hunter, "Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery", Acta Crystallographica Section D Biological Crystallography, 66 (8), 881-888 (2010), DOI: 10.1107/S0907444910020081
- Y. Alguel, D. Lu, N. Quade, S. Sauter, X. Zhang, "Crystal structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa", Journal Of Structural Biology, 172(3), 305-310 (2010), DOI: 10.1016/j.jsb.2010.07.012
- Marina Siponen, Magdalena Wisniewska, Lari Lehtio, Ida Johansson, Linda Svensson, Grzegorz Raszewski, Lennart Nilsson, Mikael Sigvardsson, Helena Berglund, "Structural determination of functional domains in Early B-cell Factor (EBF) family of transcription factors reveals similarities to rel DNA binding proteins and a novel dimerisation motif.", Journal Of Biological Chemistry, 285(34), 25875-9 (2010), DOI: 10.1074/jbc.C110.150482
- Monica Mantri, Tobias Krojer, Eleanor A. Bagg, Celia J. Webby, Danica S. Butler, Grazyna Kochan, Kathryn L. Kavanagh, Udo Oppermann, Michael A. Mcdonough, Christopher J. Schofield, "Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6", Journal Of Molecular Biology, 401 (2), 221-222 (2010), DOI: 10.1016/j.jmb.2010.05.054
- [Thesis] Amy Shaw, "Structural studies of ligand recognition by the collectins hSP-D, CL-46 and conglutinin" (2010)
- James E. Thompson, Meraj Pourhossein, Amy Waterhouse, Thomas Hudson, Marie Goldrick, Jeremy Derrick, Ian S. Roberts, "The K5 lyase KflA combines a viral tail spike structure with a bacterial polysaccharide lyase mechanism", Journal Of Biological Chemistry, 285 (31), 23963-23969 (2010), DOI: 10.1074/jbc.M110.127571
- Erica D. Sonnenburg, Hongjun Zheng, Payal Joglekar, Steven K. Higginbottom, Susan J. Firbank, David N. Bolam, Justin L. Sonnenburg, "Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations", Cell, 141 (7), 1241-1252 (2010), DOI: 10.1016/j.cell.2010.05.005
- Tom Killilea, Samantak Ghosh, Samuel Tan, Pauline Heslop, Susan Firbank, Eric Kool, Bernard Connolly, "Probing the interaction of archaeal DNA polymerases with deaminated bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues", Biochemistry, 49 (27), 57725781 (2010), DOI: 10.1021/bi100421r
- Mohd Akif, Dimitris Georgiadis, Aman Mahajan, Vincent Dive, Edward D. Sturrock, R. Elwyn Isaac, K. Ravi Acharya, "High-resolution crystal structures of Drosophila melanogaster angiotensin-converting enzyme in complex with novel inhibitors and antihypertensive drugs", Journal Of Molecular Biology, 400 (3), 502-517 (2010), DOI: 10.1016/j.jmb.2010.05.024
- Tat-Cheung Cheng, Yu Wai Chen, Kam-Bo Wong, H. Y. Edwin Chan, "Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein essential for ribosome biogenesis", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 66 (5), 546 - 548 (2010), DOI: 10.1107/S1744309110011206
- Daugirdas Tomas Racys, Dean Rea, Vilmos Fülöp, Martin Wills, "Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide", Bioorganic & Medicinal Chemistry, 18 (13), 4775 - 4782 (2010), DOI: 10.1016/j.bmc.2010.05.012
- Svend Kjær, Sarah Hanrahan, Nick Totty, Neil Q. Mcdonald, "Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations", Nature Structural & Molecular Biology, 17 (6), 726 - 731 (2010), DOI: 10.1038/nsmb.1808
- Christina Pancevac, David C. Goldstone, Andres Ramos, Ian A. Taylor, "Structure of the Rna15 RRM-RNA complex reveals the molecular basis of GU specificity in transcriptional 3'-end processing factors", Nucleic Acids Research (2010), DOI: 10.1093/nar/gkq002
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