Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
20 items found for 2008 [total: 2283]
Structures of dimeric GIT1 and trimeric β-PIX and implications for GIT–PIX complex assembly Journal Of Molecular Biology, 386 (2) Dec 2008 DOI: 10.1016/j.jmb.2008.12.050
Journal Paper I04-Macromolecular Crystallography
Structure of the wild-type human BCL6 POZ domain Acta Crystallographica Section F Structural Biology And Crystallization Communications, 64 Dec 2008 DOI: 10.1107/S1744309108036063
Journal Paper I04-Macromolecular Crystallography
The structure of the efflux pump AcrB in complex with bile acid Molecular Membrane Biology, 25 (8) Dec 2008 DOI: 10.1080/09687680802552257
Journal Paper I04-Macromolecular Crystallography
Exploring the mechanism of tryptophan 2,3-dioxygenase Biochemical Society Transactions, 36 Dec 2008 DOI: 10.1042/BST0361120
Molecular architecture of the "stressosome," a signal integration and transduction hub Science, 322 (5898) Oct 2008 DOI: 10.1126/science.1159572
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization Nature, 455(7217) Oct 2008 DOI: 10.1038/nature07394
The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines Nature Structural & Molecular Biology, 15 (10) Oct 2008 DOI: 10.1038/nsmb.1484
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural analysis of the interactions between paxillin LD motifs and α-parvin Structure, 8 (16) Oct 2008 DOI: 10.1016/j.str.2008.08.007
Uracil recognition in archaeal DNA polymerases captured by X-ray crystallography Journal Of Molecular Biology, 381 (3) Sept 2008 DOI: 10.1016/j.jmb.2008.06.004
Journal Paper I04-Macromolecular Crystallography
Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH) Journal Of Biological Chemistry, 283 (38) Sept 2008 DOI: 10.1074/jbc.M804999200
Methods development and radiation damage studies in macromolecular crystallography Sept 2008
Thesis I04-Macromolecular Crystallography
The structure of a chondroitin sulfate-binding domain important in placental malaria Journal Of Biological Chemistry, 283 (21) Aug 2008 DOI: 10.1074/jbc.C800086200
Macromolecular crystallography at Diamond Light Source: Automation and pathogenic sample environment Acta Crystallographica Section A, 64 Aug 2008 DOI: 10.1107/S0108767308094440
Poster I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Experience from operation and commissioning of the Phase 1 MX beamlines at Diamond Light Source Aug 2008
Conference Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug Proceedings Of The National Academy Of Sciences, 105 (30) Jul 2008 DOI: 10.1073/pnas.0805326105
Journal Paper I04-Macromolecular Crystallography
Structure and mechanism of an unusual malonate decarboxylase and related racemases Chemistry - A European Journal, 14 (22) June 2008 DOI: 10.1002/chem.200800918
Journal Paper I04-Macromolecular Crystallography
The FACT Spt16 'peptidase' domain is a histone H3'H4 binding module Proceedings Of The National Academy Of Sciences, 105 (26) June 2008 DOI: 10.1073/pnas.0712293105
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystallization and preliminary X-ray analysis of RsbS from Moorella thermoacetica at 2.5 Å resolution Acta Crystallographica Section F Structural Biology And Crystallization Communications, 64 (3) Mar 2008 DOI: 10.1107/S1744309108003849
Structure of the topoisomerase IV from S. pneumoniae with a DNA target and quinolone drug Acta Crystallographica Section A Foundations of Crystallography, 64 Jan 2008
Poster I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis Acta Crystallographica Section F Structural Biology And Crystallization Communications, 64 Jan 2008 DOI: 10.1107/S1744309107065931
- Oliver Schlenker, Katrin Rittinger, "Structures of dimeric GIT1 and trimeric β-PIX and implications for GIT–PIX complex assembly", Journal Of Molecular Biology, 386 (2), 280 - 9 (2008), DOI: 10.1016/j.jmb.2008.12.050
- Mark A. Stead, Gareth O. Rosbrook, Jonathan M. Hadden, Chi H. Trinh, Stephen B. Carr, Stephanie C. Wright, "Structure of the wild-type human BCL6 POZ domain", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 64, 1101 - 1104 (2008), DOI: 10.1107/S1744309108036063
- Mirjam M. Klepsch, Simon Newstead, Ralf Flaig, Jan-Willem De Gier, Konstantinos Beis, David Drew, So Iwata, "The structure of the efflux pump AcrB in complex with bile acid", Molecular Membrane Biology, 25 (8), 677 - 682 (2008), DOI: 10.1080/09687680802552257
- Sarah J. Thackray, Christopher G. Mowat, Stephen K. Chapman, "Exploring the mechanism of tryptophan 2,3-dioxygenase", Biochemical Society Transactions, 36, 1120-1123 (2008), DOI: 10.1042/BST0361120
- Jon Marles-Wright, Tim Grant, Olivier Delumeau, Gijs Van Duinen, Susan J. Firbank, Peter J. Lewis, James W. Murray, Joseph A. Newman, Maureen B. Quin, Paul R. Race, Alexis Rohou, Marin Van Heel, Richard J. Lewis, "Molecular architecture of the "stressosome," a signal integration and transduction hub", Science, 322 (5898), 92 (2008), DOI: 10.1126/science.1159572
- Massayuki Yamasaki, Wei Li, Daniel J. D. Johnson, James A. Huntington, "Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization", Nature, 455(7217), 1255 - 8 (2008), DOI: 10.1038/nature07394
- Jan Kadlec, Silvia Loureiro, Ian M. Jones, Nicola G. A. Abrescia, David I. Stuart, "The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines", Nature Structural & Molecular Biology, 15 (10), 1024 - 30 (2008), DOI: 10.1038/nsmb.1484
- Sonja Lorenz, Ioannis Vakonakis, Iain D. Campbell, Maria K. Hoellerer, Martin E. M. Noble, Edward D. Lowe, "Structural analysis of the interactions between paxillin LD motifs and α-parvin", Structure, 8 (16), 15211531 (2008), DOI: 10.1016/j.str.2008.08.007
- Susan J. Firbank, Josephine Wardle, Pauline Heslop, Richard J. Lewis, Bernard A. Connolly, "Uracil recognition in archaeal DNA polymerases captured by X-ray crystallography", Journal Of Molecular Biology, 381 (3), 529-539 (2008), DOI: 10.1016/j.jmb.2008.06.004
- K. S. Hewitson, S. L. Holmes, D. Ehrismann, A. P. Hardy, R. Chowdhury, C. J. Schofield, M. A. Mcdonough, "Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH)", Journal Of Biological Chemistry, 283 (38), 25971-25978 (2008), DOI: 10.1074/jbc.M804999200
- [Thesis] Robert John Davies, "Methods development and radiation damage studies in macromolecular crystallography" (2008)
- Matthew K. Higgins, "The structure of a chondroitin sulfate-binding domain important in placental malaria", Journal Of Biological Chemistry, 283 (21), 842-846 (2008), DOI: 10.1074/jbc.C800086200
- [Poster] David Hall, Alun Ashton, Jose Brandao-Neto, David Butler, Elizabeth Duke, Gwyndaf Evans, Ralf Flaig, Andrew Foster, Paul Gibbons, Mic Harding, Mike Latchem, Karl Levik, Katherine Mcauley, James O'Hea, Geoff Preece, James Sandy, Thomas Sorensen, David Waterman, Mark Williams, Richard Woolliscroft, "Macromolecular crystallography at Diamond Light Source: Automation and pathogenic sample environment", Acta Crystallographica Section A, 64, C174 (2008), DOI: 10.1107/S0108767308094440
- [Conference Paper] Ralf Flaig, Alun Ashton, Jose Brandao-Neto, Liz Duke, Gwyndaf Evans, Andrew Foster, Paul Gibbons, A. Grant, David Hall, Mike Latchem, Karl Levik, Katherine Mcauley, James O'Hea, Geoff Preece, James Sandy, Thomas Sorensen, David Waterman, Richard Woolliscroft, "Experience from operation and commissioning of the Phase 1 MX beamlines at Diamond Light Source" (2008)
- Frank Boeckler, Andreas C. Joerger, Gaurav Jaggi, Trevor J. Rutherford, Dimitry B. Veprintsev, Alan R. Fersht, "Targeted rescue of a destabilized mutant of p53 by an in silico screened drug", Proceedings Of The National Academy Of Sciences, 105 (30), 10360-10365 (2008), DOI: 10.1073/pnas.0805326105
- K. Okrasa, C. Levy, B. Hauer, N. Baudendistel, D. Leys, J. Micklefield, "Structure and mechanism of an unusual malonate decarboxylase and related racemases", Chemistry - A European Journal, 14 (22), 6609-6613 (2008), DOI: 10.1002/chem.200800918
- Tobias Stuwe, Michael Hothorn, Erwan Lejeune, Vladimir Rybin, Miriam Bortfeld, Klaus Scheffzek, Andreas Ladurner, "The FACT Spt16 'peptidase' domain is a histone H3'H4 binding module", Proceedings Of The National Academy Of Sciences, 105 (26), 8884-8889 (2008), DOI: 10.1073/pnas.0712293105
- Maureen Quin, Joseph Newman, Susan Firbank, Richard J. Lewis, Jon Marles-Wright, "Crystallization and preliminary X-ray analysis of RsbS from Moorella thermoacetica at 2.5 Å resolution", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 64 (3), 196 - 199 (2008), DOI: 10.1107/S1744309108003849
- [Poster] Ivan Laponogov, Maninder Sohi, Dennis Veselkov, Xiao-Su Pan, Ritica Sawhney, Andrew Thompson, L . Mark Fisher, Mark Sanderson, "Structure of the topoisomerase IV from S. pneumoniae with a DNA target and quinolone drug", Acta Crystallographica Section A Foundations of Crystallography, 64, C307 (2008)
- Nathan Lack, Edward D. Lowe, Jie Liu, Lindsay D. Eltis, Martin E. M. Noble, Edith Sim, Isaac M. Westwood, "Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 64, 2 - 7 (2008), DOI: 10.1107/S1744309107065931
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