Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
94 items found for 2012 [total: 2283]
Crystal structure of the small GTPase Arl6/BBS3 from Trypanosomabrucei Protein Science, Dec 2012 DOI: 10.1002/pro.2198
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity Journal Of Medicinal Chemistry, 56 (3) Dec 2012 DOI: 10.1021/jm301495v
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Crystal structures of MBOgg1 in complex with two abasic DNA ligands Journal Of Structural Biology, 181 (3) Dec 2012 DOI: 10.1016/j.jsb.2012.12.003
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin Proceedings Of The National Academy Of Sciences, 109 (52) Dec 2012 DOI: 10.1073/pnas.1218841110
Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint) Biochemical Journal, 448 Dec 2012 DOI: 10.1042/BJ20121448
Probing the conformational mobility of the active site of a heme peroxidase Dalton Transactions, Dec 2012 DOI: 10.1039/c2dt32455e
Journal Paper I04-Macromolecular Crystallography
Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex Proceedings Of The National Academy Of Sciences, Dec 2012 DOI: 10.1073/pnas.1214735109
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages Plos One, 7 (12) Dec 2012 DOI: 10.1371/journal.pone.0052790
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation Structure, 20 (12) Dec 2012 DOI: 10.1016/j.str.2012.09.005
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-Actin reveal the molecular basis for actin binding cooperativity Structure, 20 (11) Nov 2012 DOI: 10.1016/j.str.2012.08.031
Journal Paper I04-Macromolecular Crystallography
Crystal structure of the human IgG4 CH3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange Molecular Immunology, 54 (1) Nov 2012 DOI: 10.1016/j.molimm.2012.10.029
Journal Paper I04-Macromolecular Crystallography
Structural insights into the mechanisms of Mg2+ uptake, transport, and gating by CorA Proceedings Of The National Academy Of Sciences, 109 (45) Nov 2012 DOI: 10.1073/pnas.1210076109
Journal Paper I04-Macromolecular Crystallography
P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy Journal Of Medicinal Chemistry, 55 (22) Nov 2012 DOI: 10.1021/jm301060g
Journal Paper I04-Macromolecular Crystallography
In situ beamline analysis and correction of active optics Journal Of Synchrotron Radiation, 19 (6) Nov 2012 DOI: 10.1107/S090904951203662X
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I15-Extreme Conditions I19-Small Molecule Single Crystal Diffraction I20-Scanning-X-ray spectroscopy (XAS/XES) I22-Small angle scattering & Diffraction
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B Journal Of Medicinal Chemistry, 55 (21) Nov 2012 DOI: 10.1021/jm301034u
An improved racemase/acylase biotransformation for the preparation of enantiomerically pure amino acids Journal Of The American Chemical Society, 134 (47) Nov 2012 DOI: 10.1021/ja305438y
Tic22 is an essential chaperone required for protein import into the apicoplast Journal Of Biological Chemistry, 287 (47) Nov 2012 DOI: 10.1074/jbc.M112.405100
Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides Scientific Reports, 2 Oct 2012 DOI: 10.1038/srep00717
Production and crystallization of the C-propeptide trimer from human procollagen III Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (10) Oct 2012 DOI: 10.1107/S1744309112035294
Structures of a γ-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP–GABA adduct Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (10) Oct 2012 DOI: 10.1107/S1744309112030023
Journal Paper I04-Macromolecular Crystallography
Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis Proceedings Of The National Academy Of Sciences, 109 (42) Oct 2012 DOI: 10.1073/pnas.1206563109
Crystal structure of human CDC7 kinase in complex with its activator DBF4 Nature Structural & Molecular Biology, 19 (11) Oct 2012 DOI: 10.1038/nsmb.2404
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons Nature Communications, 3 Oct 2012 DOI: 10.1038/ncomms2126
Structural insight into the Clostridium difficile ethanolamine utilisation microcompartment Plos One, 7 (10) Oct 2012 DOI: 10.1371/journal.pone.0048360
Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules Plos Pathogens, 8 (10) Oct 2012 DOI: 10.1371/journal.ppat.1002981
An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis Nature Chemical Biology, 8 (11) Oct 2012 DOI: 10.1038/nchembio.1086
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis Plos Pathogens, 8 (9) Oct 2012 DOI: 10.1371/journal.ppat.1002914
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes Proceedings Of The National Academy Of Sciences, 109 (43) Oct 2012 DOI: 10.1073/pnas.1206839109
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing Nature Communications, 3 Oct 2012 DOI: 10.1038/ncomms2077
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
The reaction coordinate of a bacterial GH47 α-mannosidase: a combined quantum mechanical and structural approach Angewandte Chemie International Edition, 51 (44) Oct 2012 DOI: 10.1002/anie.201205338
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Crystallization, dehydration and experimental phasing of WbdD, a bifunctional kinase and methyltransferase from Escherichia coli O9a Acta Crystallographica Section D Biological Crystallography, 68 (10) Oct 2012 DOI: 10.1107/S0907444912029599
Distinct regions of the Pseudomonas syringae coiled-coil effector AvrRps4 are required for activation of immunity Proceedings Of The National Academy Of Sciences, Sept 2012 DOI: 10.1073/pnas.1212332109
Structural basis of fibrillar collagen trimerization and related genetic disorders Nature Structural & Molecular Biology, 19 (10) Sept 2012 DOI: 10.1038/nsmb.2389
Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121 Angewandte Chemie International Edition, 51 (37) Sept 2012 DOI: 10.1002/anie.201202544
Structure of WbdD; a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coliO9a Molecular Microbiology, Sept 2012 DOI: 10.1111/mmi.12014
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance Journal Of Thrombosis And Haemostasis, 10 (9) Sept 2012 DOI: 10.1111/j.1538-7836.2012.04839.x
Journal Paper I04-Macromolecular Crystallography
Crystal structure of human Aurora B in complex with INCENP and VX-680 Journal Of Medicinal Chemistry, 55 (17) Sept 2012 DOI: 10.1021/jm3008954
Trp RNA-binding attenuation protein: modifying symmetry and stability of a circular oligomer Plos One, 7 (9) Sept 2012 DOI: 10.1371/journal.pone.0044309
Structures of lysenin reveal a shared evolutionary origin for pore-forming proteins and its mode of sphingomyelin recognition Structure, 20 (9) Sept 2012 DOI: 10.1016/j.str.2012.06.011
The crystal structure of the lipid II-degrading bacteriocin syringacin M suggests unexpected evolutionary relationships between colicin M-like bacteriocins Journal Of Biological Chemistry, Sept 2012 DOI: 10.1074/jbc.M112.400150
Interaction of pentraxins and collectins with lipopolysaccharide ligands Aug 2012
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Crystal structures of lambda-[Ru(phen)2dppz]2+ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes Nature Chemistry, 4 (8) Aug 2012 DOI: 10.1038/nchem.1397
Structural basis for the activity of a cytoplasmic RNA terminal uridylyl transferase Nature Structural & Molecular Biology, 19 (8) Aug 2012 DOI: 10.1038/nsmb.2329
Useable diffraction data from a multiple microdomain-containing crystal of Ascaris suum As-p18 fatty-acid-binding protein using a microfocus beamline Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (8) Aug 2012 DOI: 10.1107/S1744309112026553
The structural basis of differential DNA sequence recognition by restriction-modification controller proteins Nucleic Acids Research, Aug 2012 DOI: 10.1093/nar/gks718
Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design Proceedings Of The National Academy Of Sciences, 109 (33) Aug 2012 DOI: 10.1073/pnas.1118622109
Journal Paper I04-Macromolecular Crystallography
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response Nature, 488 Aug 2012 DOI: 10.1038/nature11262
Journal Paper I04-Macromolecular Crystallography
BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer Nature Structural & Molecular Biology, 19 (9) Aug 2012 DOI: 10.1038/nsmb.2379
The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, Aug 2012 DOI: 10.1016/j.bbapap.2012.08.012
Journal Paper I04-Macromolecular Crystallography
TCR/pMHC optimized protein crystallization screen Journal Of Immunological Methods, 382 Aug 2012 DOI: 10.1016/j.jim.2012.06.007
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Oomycetes, effectors, and all that jazz Current Opinion In Plant Biology, 15 (4) Aug 2012 DOI: 10.1016/j.pbi.2012.03.008
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors Proceedings Of The National Academy Of Sciences, 109 (28) Jul 2012 DOI: 10.1073/pnas.1205735109
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Purification, crystallization and preliminary X-ray characterization of the Acetivibrio cellulolyticus type I cohesin ScaC in complex with the ScaB dockerin Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 Jul 2012 DOI: 10.1107/S1744309112031922
Journal Paper I04-Macromolecular Crystallography
Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FceRI Proceedings Of The National Academy Of Sciences, 109 (31) Jul 2012 DOI: 10.1073/PNAS.1207278109
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (7) Jul 2012 DOI: 10.1107/S1744309112023597
Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism Blood, 120 (2) Jul 2012 DOI: 10.1182/blood-2012-03-415869
Crystallization of SHARPIN using an automated two-dimensional grid screen for optimization Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (7) Jul 2012 DOI: 10.1107/S1744309112022208
Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system Proceedings Of The National Academy Of Sciences, 109 (28) Jul 2012 DOI: 10.1073/pnas.1201428109
Crystal structures of the network-forming short-arm tips of the laminin β1 and γ1 chains Plos One, 7 (7) Jul 2012 DOI: 10.1371/journal.pone.0042473
The crystal structure of the extracellular 11-heme cytochrome UndA reveals a conserved 10-heme motif and defined binding site for soluble iron chelates Structure, 20 (7) Jul 2012 DOI: 10.1016/j.str.2012.04.016
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria Journal Of Biological Chemistry, 287 (29) Jul 2012 DOI: 10.1074/jbc.M112.368191
Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold Journal Of Biological Chemistry, 287 (25) June 2012 DOI: 10.1074/jbc.M112.359547
The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks Nature Structural & Molecular Biology, 19 (7) June 2012 DOI: 10.1038/nsmb.2335
Alternating access mechanism in the POT family of oligopeptide transporters The Embo Journal, 31 (16) June 2012 DOI: 10.1038/emboj.2012.157
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Unusual spectroscopic and ligand binding properties of the cytochrome P450-flavodoxin fusion enzyme XplA Journal Of Biological Chemistry, 287 (23) June 2012 DOI: 10.1074/jbc.M111.319202
Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase Nature Communications, 3 (878) June 2012 DOI: 10.1038/ncomms1889
Journal Paper I04-Macromolecular Crystallography
Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (6) June 2012 DOI: 10.1107/S1744309112017915
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology Acs Synthetic Biology, 1 (6) June 2012 DOI: 10.1021/sb300028q
The structure of an orthorhombic crystal form of a 'forced reduced' thiol peroxidase reveals lattice formation aided by the presence of the affinity tag Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (5) May 2012 DOI: 10.1107/S1744309112011487
Journal Paper I04-Macromolecular Crystallography
'Seeding’ with protease to optimize protein crystallization conditions in in situ proteolysis Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (5) May 2012 DOI: 10.1107/S174430911201161X
A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system Proceedings Of The National Academy Of Sciences, 109 (19) May 2012 DOI: 10.1073/pnas.1200479109
Crystallization and preliminary crystallographic analysis of the major capsid proteins VP16 and VP17 of bacteriophage P23-77 Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (5) May 2012 DOI: 10.1107/S1744309112010330
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural analysis of a dengue cross-reactive antibody complexed with envelope domain III reveals the molecular basis of cross-reactivity The Journal Of Immunology, 188 (10) May 2012 DOI: 10.4049/jimmunol.1200227
Journal Paper I04-Macromolecular Crystallography
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53 Journal Of The American Chemical Society, 134 (15) Apr 2012 DOI: 10.1021/ja301056a
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Staphylococcal biofilm-forming protein has a contiguous rod-like structure Proceedings Of The National Academy Of Sciences, 109 (17) Apr 2012 DOI: 10.1073/pnas.1119456109
Structure of components of an intercellular channel complex in sporulating Bacillus subtilis Proceedings Of The National Academy Of Sciences, 109 (14) Apr 2012 DOI: 10.1073/pnas.1120087109
Introducing endo-xylanase activity into an exo-acting arabinofuranosidase that targets side chains Proceedings Of The National Academy Of Sciences, 109 (17) Apr 2012 DOI: 10.1073/pnas.1117686109
Journal Paper I04-Macromolecular Crystallography
The response to copper stress in Streptomyces lividans extends beyond genes under the direct control of a Copper sensitive operon Repressor protein (CsoR) Journal Of Biological Chemistry, 287 (21) Mar 2012 DOI: 10.1074/jbc.M112.352740
Structural and functional characterization of the product of disease-related factor H gene conversion Biochemistry, 51 (9) Mar 2012 DOI: 10.1021/bi201689j
Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus Proceedings Of The National Academy Of Sciences, 109 (10) Mar 2012 DOI: 10.1073/pnas.1106733109
Overproduction, purification and crystallization of PfTic22, a component of the import apparatus from the apicoplast of Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (3) Mar 2012 DOI: 10.1107/S1744309112004952
Journal Paper I04-Macromolecular Crystallography
Crystal structure of a Trypanosoma brucei metacaspase Proceedings Of The National Academy Of Sciences, 109 Mar 2012 DOI: 10.1073/pnas.1200885109
Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of human dihydrouridine synthase Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (3) Mar 2012 DOI: 10.1107/S1744309112003831
Journal Paper I04-Macromolecular Crystallography
Histone recognition and large-scale structural analysis of the human bromodomain family Cell, 149 (1) Mar 2012 DOI: 10.1016/j.cell.2012.02.013
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Mutational analysis of phenolic acid decarboxylase from Bacillus subtilis (BsPAD), which converts bio-derived phenolic acids to styrene derivatives Catalysis Science & Technology, 2 Mar 2012 DOI: 10.1039/c2cy20015e
Journal Paper I04-Macromolecular Crystallography
Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly Nucleic Acids Research, 40 (5) Mar 2012 DOI: 10.1093/nar/gkr765
Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds Plos One, 7 (2) Feb 2012 DOI: 10.1371/journal.pone.0032217
An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid Nature Communications, 3 Feb 2012 DOI: 10.1038/ncomms1680
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Three-dimensional structure of a thermophilic family GH11 xylanase from Thermobifida fusca Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (2) Feb 2012 DOI: 10.1107/S1744309111049608
Journal Paper I04-Macromolecular Crystallography
The bacterial stressosome: a modular system that has been adapted to control secondary messenger signaling Structure, 20 (2) Feb 2012 DOI: 10.1016/j.str.2012.01.003
Crystal structure of the Psb27 assembly factor at 1.6 Å: implications for binding to Photosystem II Photosynthesis Research, 110 (3) Feb 2012 DOI: 10.1007/s11120-011-9712-7
Journal Paper I04-Macromolecular Crystallography
Structural basis for DNA recognition and loading into a viral packaging motor Proceedings Of The National Academy Of Sciences, 109 (3) Jan 2012 DOI: 10.1073/pnas.1110270109
An enlarged, adaptable active site in CYP164 family P450 enzymes, the sole P450 in Mycobacterium leprae Antimicrobial Agents And Chemotherapy, 56 (1) Jan 2012 DOI: 10.1128/AAC.05227-11
Sequence divergent RXLR effectors share a structural fold conserved across plant pathogenic oomycete species Plos Pathogens, 8 (1) Jan 2012 DOI: 10.1371/journal.ppat.1002400
- Glyn R. Hemsworth, Helen P. Price, Deborah F. Smith, Keith S. Wilson, "Crystal structure of the small GTPase Arl6/BBS3 from Trypanosomabrucei", Protein Science (2012), DOI: 10.1002/pro.2198
- Alison J. Hole, Sonja Baumli, Hao Shao, Shenhua Shi, Chris Pepper, Peter M. Fischer, Shudong Wang, Jane A. Endicott, Martin E. Noble, "Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity", Journal Of Medicinal Chemistry, 56 (3) (2012), DOI: 10.1021/jm301495v
- Hongjun Yu, Mingzhang Yang, Xian-En Zhang, Lijun Bi, Tao Jiang, "Crystal structures of MBOgg1 in complex with two abasic DNA ligands", Journal Of Structural Biology, 181 (3) (2012), DOI: 10.1016/j.jsb.2012.12.003
- Y. P. Lin, X. Xiong, S. A. Wharton, S. R. Martin, P. J. Coombs, S. G. Vachieri, E. Christodoulou, P Walker, J. Liu, J. J. Skehel, S Gamblin, A. J. Hay, R. S. Daniels, J. W. Mccauley, "Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin", Proceedings Of The National Academy Of Sciences, 109 (52), 21474 - 21479 (2012), DOI: 10.1073/pnas.1218841110
- Philippe Thebault, Dimitri Y. Chirgadze, Zhen Dou, Tom Blundell, Sabine Elowe, Victor Bolanos-Garcia, "Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)", Biochemical Journal, 448, 321 - 328 (2012), DOI: 10.1042/BJ20121448
- Andrea Guimero, Sandip K. Badyal, Tina Leeks, Peter Moody, Emma Raven, "Probing the conformational mobility of the active site of a heme peroxidase", Dalton Transactions (2012), DOI: 10.1039/c2dt32455e
- Matheshwaran Saravanan, Jochen Wuerges, Daniel Bose, Elizabeth A. Mccormack, Nicola J. Cook, Xiaodong Zhang, Dale B. Wigley, "Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex", Proceedings Of The National Academy Of Sciences (2012), DOI: 10.1073/pnas.1214735109
- Areej Abuhammad, Elizabeth Fullam, Edward Lowe, David Staunton, Akane Kawamura, Isaac Westwood, Sanjib Bhakta, Alun Christopher Garner, David L. Wilson, Peter T. Seden, Stephen G. Davies, Angela J. Russell, Elspeth F. Garman, Edith Sim, "Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages", Plos One, 7 (12) (2012), DOI: 10.1371/journal.pone.0052790
- Tom D. Bunney, Diego Esposito, Corine Mas-Droux, Ekatarina Lamber, Rhona W. Baxendale, Marta Martins, Ambrose Cole, Dmitri Svergun, Paul C. Driscoll, Matilda Katan, "Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation", Structure, 20 (12), 2062 - 2075 (2012), DOI: 10.1016/j.str.2012.09.005
- Stephane Mouilleron, Maria Wiezlak, Nicola O'Reilly, Richard Treisman, Neil q. Mcdonald, "Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-Actin reveal the molecular basis for actin binding cooperativity", Structure, 20 (11), 1960 - 1970 (2012), DOI: 10.1016/j.str.2012.08.031
- Anna M. Davies, Theo Rispens, Tamara H. Den Bleker, James M. Mcdonnell, Hannah J. Gould, Rob C. Aalberse, Brian J. Sutton, "Crystal structure of the human IgG4 CH3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange", Molecular Immunology, 54 (1), 1 - 7 (2012), DOI: 10.1016/j.molimm.2012.10.029
- A. Guskov, N. Nordin, A. Reynaud, H. Engman, A.-K. Lundback, A. J. O. Jong, T. Cornvik, T. Phua, S. Eshaghi, "Structural insights into the mechanisms of Mg2+ uptake, transport, and gating by CorA", Proceedings Of The National Academy Of Sciences, 109 (45), 18459 - 18464 (2012), DOI: 10.1073/pnas.1210076109
- Pieter Van Der Veken, Vilmos Fulop, Dean Rea, Melanie Gerard, Roos Van Elzen, Jurgen Joossens, Jonathan D. Cheng, Veerle Baekelandt, Ingrid De Meester, Anne-Marie Lambeir, Koen Augustyns, "P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy", Journal Of Medicinal Chemistry, 55 (22), 9856 - 9867 (2012), DOI: 10.1021/jm301060g
- John Sutter, Simon Alcock, Kawal Sawhney, "In situ beamline analysis and correction of active optics", Journal Of Synchrotron Radiation, 19 (6), 960 - 968 (2012), DOI: 10.1107/S090904951203662X
- Tania Tahtouh, Jonathan M. Elkins, Panagis Filippakopoulos, Meera Soundararajan, Guillaume Burgy, Emilie Durieu, Claude Cochet, Ralf S. Schmid, Donald C. Lo, Florent Delhommel, Anselm E. Oberholzer, Laurence H. Pearl, François Carreaux, Jean-Pierre Bazureau, Stefan Knapp, Laurent Meijer, "Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B", Journal Of Medicinal Chemistry, 55 (21), 9312 - 9330 (2012), DOI: 10.1021/jm301034u
- Scott Baxter, Sylvain Royer, Gideon Grogan, Fraser Brown, Karen E. Holt-Tiffin, Ian N. Taylor, Ian G. Fotheringham, Dominic J. Campopiano, "An improved racemase/acylase biotransformation for the preparation of enantiomerically pure amino acids", Journal Of The American Chemical Society, 134 (47), 19310 - 19313 (2012), DOI: 10.1021/ja305438y
- S. Glaser, G. G. Van Dooren, S. Agrawal, C. F. Brooks, G. I. Mcfadden, B. Striepen, M. Higgins, "Tic22 is an essential chaperone required for protein import into the apicoplast", Journal Of Biological Chemistry, 287 (47), 39505 - 39512 (2012), DOI: 10.1074/jbc.M112.405100
- Geoffrey Masuyer, Sylva L. U. Schwager, Edward D. Sturrock, R. Elwyn Isaac, K. Ravi Acharya, "Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides", Scientific Reports, 2 (2012), DOI: 10.1038/srep00717
- J.-M. Bourhis, N. Mariano, Y. Zhao, T. S. Walter, K. El Omari, F. Delolme, C. Moali, D. J. S. Hulmes, N. Aghajari, "Production and crystallization of the C-propeptide trimer from human procollagen III", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (10), 1209 - 1213 (2012), DOI: 10.1107/S1744309112035294
- Heather Bruce, Anh Nguyen Tuan, Juan Mangas Sánchez, Charlotte Leese, Jennifer Hopwood, Ralph Hyde, Sam Hart, Johan P. Turkenburg, Gideon Grogan, "Structures of a γ-aminobutyrate (GABA) transaminase from the s-triazine-degrading organism Arthrobacter aurescens TC1 in complex with PLP and with its external aldimine PLP–GABA adduct", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 68 (10), 1175 - 1180 (2012), DOI: 10.1107/S1744309112030023
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