Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
118 items found for 2014 [total: 2283]
Crystallization and preliminary X-ray diffraction analysis of a trimodular endo-[beta]-1,4-glucanase (Cel5B) from Bacillus halodurans Acta Crystallographica Section F Structural Biology Communications, 70 Dec 2014 DOI: 10.1107/S2053230X1402319X
Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli Plos One, 9 (12) Dec 2014 DOI: 10.1371/journal.pone.0114691
Structural and functional studies of proteins in cell signaling and cancer Dec 2014
Thesis I04-Macromolecular Crystallography
Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase Nature, 516 (7529) Dec 2014 DOI: 10.1038/nature14003
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Expression, purification and X-ray crystallographic analysis of the Helicobacter pylori blood group antigen-binding adhesin BabA Acta Crystallographica Section F Structural Biology Communications, 70 Dec 2014 DOI: 10.1107/S2053230X14023188
Journal Paper I04-Macromolecular Crystallography
Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger Acs Chemical Biology, 9 (12) Dec 2014 DOI: 10.1021/cb500585s
Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1 Acta Crystallographica Section F Structural Biology Communications, 70 Dec 2014 DOI: 10.1107/S2053230X14023449
Journal Paper I04-Macromolecular Crystallography
Characterisation of the morphological and surface properties of organic micro-crystalline particles Dec 2014
Thesis I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator Febs Letters, 588 (24) Dec 2014 DOI: 10.1016/j.febslet.2014.11.002
The structural biology of patellamide biosynthesis Current Opinion In Structural Biology, 29 Dec 2014 DOI: 10.1016/j.sbi.2014.10.006
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activation Journal Of Biological Chemistry, 289 (52) Dec 2014 DOI: 10.1074/jbc.M114.610782
The crystal structures of Apo and cAMP-bound GlxR from Corynebacterium glutamicum reveal structural and dynamic changes upon cAMP binding in CRP/FNR family transcription factors Plos One, 9 (12) Dec 2014 DOI: 10.1371/journal.pone.0113265
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Scientists gain first glimpse of one of nature's measuring 'rulers' Dec 2014
Science Highlight B23-Circular Dichroism I04-Macromolecular Crystallography
Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis Nature Communications, 5 Nov 2014 DOI: 10.1038/ncomms6209
Rhodanine hydrolysis leads to potent thioenolate mediated metallo-beta-lactamase inhibition Nature Chemistry, 6 (12) Nov 2014 DOI: 10.1038/nchem.2110
Journal Paper I04-Macromolecular Crystallography
Coevolution of the ATPase ClpV, the sheath proteins TssB and TssC, and the accessory protein TagJ/HsiE1 distinguishes type VI secretion classes Journal Of Biological Chemistry, 289 (47) Nov 2014 DOI: 10.1074/jbc.M114.600510
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis Journal Of Biological Chemistry, 289 (45) Nov 2014 DOI: 10.1074/jbc.M114.579771
Structure and function of a spectrin-like regulator of bacterial cytokinesis Nature Communications, 5 Nov 2014 DOI: 10.1038/ncomms6421
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies Nature, 515 (7527) Nov 2014 DOI: 10.1038/nature13715
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Secondary structure reshuffling modulates glycosyltransferase function at the membrane Nature Chemical Biology, 11 (1) Nov 2014 DOI: 10.1038/nchembio.1694
Journal Paper I04-Macromolecular Crystallography
Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target Plos One, 9 (11) Nov 2014 DOI: 10.1371/journal.pone.0113568
Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus Journal Of Biological Chemistry, 289 (48) Nov 2014 DOI: 10.1074/jbc.M114.608448
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
BET inhibition as a new strategy for the treatment of gastric cancer Oncotarget, Nov 2014 DOI: 10.18632/oncotarget.9766
Untangling the mysteries of curli fibres Nov 2014
Science Highlight I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development Neuron, 84 (2) Oct 2014 DOI: 10.1016/j.neuron.2014.10.008
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure-guided design and optimization of small molecules targeting the protein–protein interaction between the von Hippel–Lindau (VHL) E3 ubiquitin ligase and the Hypoxia Inducible Factor (HIF) alpha subunit with in vitro nanomolar affinities Journal Of Medicinal Chemistry, 57 (20) Oct 2014 DOI: 10.1021/jm5011258
Photo-oxidation of tyrosine in a bio-engineered bacterioferritin 'reaction centre’ - A protein model for artificial photosynthesis Biochimica Et Biophysica Acta (bba) - Bioenergetics, 1837 (10) Oct 2014 DOI: 10.1016/j.bbabio.2014.07.019
Journal Paper I04-Macromolecular Crystallography
Structure-based design of potent and selective leishmaniaN-myristoyltransferase inhibitors Journal Of Medicinal Chemistry, 57 (20) Oct 2014 DOI: 10.1021/jm5011397
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective bet bromodomain inhibitor Journal Of Medicinal Chemistry, 57 (19) Oct 2014 DOI: 10.1021/jm5010539
Journal Paper I04-Macromolecular Crystallography
New methods for indexing multi-lattice diffraction data Acta Crystallographica Section D Biological Crystallography, 70 Oct 2014 DOI: 10.1107/S1399004714017039
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation Nature, 517 (7535) Oct 2014 DOI: 10.1038/nature13901
Journal Paper I04-Macromolecular Crystallography
Computational design of water-soluble alpha-helical barrels Science, 346 (6208) Oct 2014 DOI: 10.1126/science.1257452
Structure and function of cohesin's Scc3/SA regulatory subunit Febs Letters, 588 (20) Oct 2014 DOI: 10.1016/j.febslet.2014.08.015
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Love–Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interaction Bioorganic & Medicinal Chemistry, 22 (19) Oct 2014 DOI: 10.1016/j.bmc.2014.07.029
Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1 Nature Communications, 5 Sept 2014 DOI: 10.1038/ncomms5874
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface The Faseb Journal, 28 (10) Sept 2014 DOI: 10.1096/fj.14-256057
Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG Nature, Sept 2014 DOI: 10.1038/nature13768
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics Nature Chemical Biology, 10 (10) Sept 2014 DOI: 10.1038/nchembio.1629
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase Nature Communications, 5 Sept 2014 DOI: 10.1038/ncomms5805
Journal Paper I04-Macromolecular Crystallography
Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation Proceedings Of The National Academy Of Sciences, 111 (37) Sept 2014 DOI: 10.1073/pnas.1409916111
Carboplatin binding to histidine Acta Crystallographica Section F Structural Biology Communications, 70 Sept 2014 DOI: 10.1107/S2053230X14016161
Structures of pyruvate kinases display evolutionarily divergent allosteric strategies Royal Society Open Science, 1 Sept 2014 DOI: 10.1098/rsos.140120
A novel I221L substitution in neuraminidase confers high-level resistance to oseltamivir in influenza B viruses Journal Of Infectious Diseases, 210 (8) Sept 2014 DOI: 10.1093/infdis/jiu244
Molecular basis of nucleotide-dependent substrate engagement and remodeling by an AAA+ activator Nucleic Acids Research, 42 (14) Aug 2014 DOI: 10.1093/nar/gku588
The structure of a PII signaling protein from a halophilic archaeon reveals novel traits and high-salt adaptations Febs Journal, 281 (15) Aug 2014 DOI: 10.1111/febs.12881
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 Journal Of Medicinal Chemistry, 57 (15) Aug 2014 DOI: 10.1021/jm500483b
Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor Proceedings Of The National Academy Of Sciences, 111 (31) Aug 2014 DOI: 10.1073/pnas.1403737111
Journal Paper I04-Macromolecular Crystallography
Pushing the limits of sulfur SAD phasing: de novo structure solution of the N-terminal domain of the ectodomain of HCV E1 Acta Crystallographica Section D Biological Crystallography, 70 Aug 2014 DOI: 10.1107/S139900471401339X
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5 Proceedings Of The National Academy Of Sciences, 111 (34) Aug 2014 DOI: 10.1073/pnas.1405391111
Journal Paper I04-Macromolecular Crystallography
Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction Acs Chemical Biology, 9 (10) Aug 2014 DOI: 10.1021/cb500271c
Molecular mechanism of ligand recognition by membrane transport protein, Mhp1 The Embo Journal, 33 (16) Aug 2014 DOI: 10.15252/embj.201387557
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Overexpression, crystallization and preliminary X-ray characterization of Ruminococcus flavefaciens scaffoldin C cohesin in complex with a dockerin from an uncharacterized CBM-containing protein Acta Crystallographica Section F Structural Biology Communications, 70 Aug 2014 DOI: 10.1107/S2053230X14012667
Journal Paper I04-Macromolecular Crystallography
Insight into the architecture of the NuRD complex: structure of the Rbap48-Mta1 subcomplex Journal Of Biological Chemistry, 289 (32) Aug 2014 DOI: 10.1074/jbc.M114.558940
Structure of the virulence-associated protein VapD from the intracellular pathogen Rhodococcus equi Acta Crystallographica Section D Biological Crystallography, 70 Aug 2014 DOI: 10.1107/S1399004714012632
Loop electrostatics modulates the intersubunit interactions in ferritin Acs Chemical Biology, 9 (11) Aug 2014 DOI: 10.1021/cb500431r
Journal Paper I04-Macromolecular Crystallography
Structural and dynamic changes associated with beneficial engineered single-amino-acid deletion mutations in enhanced green fluorescent protein Acta Crystallographica Section D Biological Crystallography, 70 Aug 2014 DOI: 10.1107/S139900471401267X
Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity Medchemcomm, 5 Aug 2014 DOI: 10.1039/C4MD00280F
Journal Paper I04-Macromolecular Crystallography
FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain Cell Reports, 8 (1) Jul 2014 DOI: 10.1016/j.celrep.2014.06.001
Structure and function study of the complex that synthesizes Iucrj, 1 Jul 2014 DOI: 10.1107/S2052252514012585
Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors Iucrj, 1 Jul 2014 DOI: 10.1107/S2052252514013001
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural basis of chitin oligosaccharide deacetylation Angewandte Chemie International Edition, 53 (27) Jul 2014 DOI: 10.1002/anie.201400220
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural and biochemical characterization of human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A Plos One, 9 (7) Jul 2014 DOI: 10.1371/journal.pone.0101846
Recent evolution of equine influenza and the origin of canine influenza Proceedings Of The National Academy Of Sciences, 111 (30) Jul 2014 DOI: 10.1073/pnas.1406606111
Crystallization of the carboxy-terminal region of the bacteriophage T4 proximal long tail fibre protein gp34 Acta Crystallographica Section F Structural Biology Communications, 70 Jul 2014 DOI: 10.1107/S2053230X14010449
Journal Paper I04-Macromolecular Crystallography
Modular riboswitch toolsets for synthetic genetic control in diverse bacterial species Journal Of The American Chemical Society, 136 (30) Jul 2014 DOI: 10.1021/ja502873j
Crystallization and preliminary analysis of the NqrA and NqrC subunits of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae Acta Crystallographica Section F Structural Biology Communications, 70 (7) Jul 2014 DOI: 10.1107/S2053230X14009881
Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible t-cell kinase inhibitors Journal Of Medicinal Chemistry, 57 (13) Jul 2014 DOI: 10.1021/jm500550e
Journal Paper I04-Macromolecular Crystallography
Structures and binding specificity of galactose- and mannose-binding lectins from champedak: differences from jackfruit lectins Acta Crystallographica Section F Structural Biology Communications, 70 June 2014 DOI: 10.1107/S2053230X14008966
Journal Paper I04-Macromolecular Crystallography
A tale of tails: deciphering the contribution of terminal tails to the biochemical properties of two Dps proteins from Streptomyces coelicolor Cellular And Molecular Life Sciences, June 2014 DOI: 10.1007/s00018-014-1658-4
Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export Nucleic Acids Research, 42 (10) June 2014 DOI: 10.1093/nar/gku252
A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation–π interaction Angewandte Chemie International Edition, 53 (24) June 2014 DOI: 10.1002/anie.201402750
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1 Structure, 22 (6) June 2014 DOI: 10.1016/j.str.2014.04.001
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Membrane proteins bind lipids selectively to modulate their structure and function Nature, 510 (7503) June 2014 DOI: 10.1038/nature13419
Journal Paper I04-Macromolecular Crystallography
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism Proceedings Of The National Academy Of Sciences, 111 (23) June 2014 DOI: 10.1073/pnas.1406855111
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Insight into the structural and biological relevance of the T/R transition of the N-rerminus of the B-chain in human insulin Biochemistry, 53 (21) June 2014 DOI: 10.1021/bi500073z
Structural basis for outer membrane lipopolysaccharide insertion Nature, 511 (7507) June 2014 DOI: 10.1038/nature13464
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Overproduction, purification, crystallization and preliminary X-ray characterization of the family 46 carbohydrate-binding module (CBM46) of endo-beta-1,4-glucanase B (CelB) from Bacillus halodurans Acta Crystallographica Section F Structural Biology Communications, 70 June 2014 DOI: 10.1107/S2053230X14008395
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
HELIX: a new modular nucleic acid crystallization screen Journal Of Applied Crystallography, 47 (3) June 2014 DOI: 10.1107/S1600576714007407
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Characterization of two homologous 2′-O-methyltransferases showing different specificities for their tRNA substrates Rna, 20 (8) June 2014 DOI: 10.1261/rna.044503.114
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Enhanced human receptor binding by H5 haemagglutinins Virology, 456 May 2014 DOI: 10.1016/j.virol.2014.03.008
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Bacterial actin MreB forms antiparallel double filaments Elife, 3 May 2014 DOI: 10.7554/eLife.02634
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
A Ctf4 trimer couples the CMG helicase to DNA polymerase alpha in the eukaryotic replisome Nature, 510 (7504) May 2014 DOI: 10.1038/nature13234
Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae Elife, 3 May 2014 DOI: 10.7554/eLife.02674
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystallization and preliminary X-ray crystallographic analysis of a novel alpha-L-arabinofuranosidase (CtGH43) from Clostridium thermocellum ATCC 27405 Acta Crystallographica Section F Structural Biology Communications, 70 May 2014 DOI: 10.1107/S2053230X14006402
Journal Paper I04-Macromolecular Crystallography
Purification, crystallization and preliminary X-ray diffraction analysis of GatD, a glutamine amidotransferase-like protein from Acta Crystallographica Section F Structural Biology Communications, 70 May 2014 DOI: 10.1107/S2053230X14007298
Molecular basis and regulation of OTULIN-LUBAC interaction Molecular Cell, 54 (3) May 2014 DOI: 10.1016/j.molcel.2014.03.018
Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line Open Biology, 4 (5) May 2014 DOI: 10.1098/rsob.140041
The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca Febs Journal, 281 (9) May 2014 DOI: 10.1111/febs.12778
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex Biochemical Journal, 463 May 2014 DOI: 10.1042/BJ20140359
Journal Paper I04-Macromolecular Crystallography
Ribosomal oxygenases are structurally conserved from prokaryotes to humans Nature, 509 (7505) May 2014 DOI: 10.1038/nature13263
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Analysis of an industrial production suspension of Bacillus lentus subtilisin crystals by powder diffraction: a powerful quality-control tool Acta Crystallographica Section D Biological Crystallography, 70 Apr 2014 DOI: 10.1107/S1399004714001497
Crystal structure and molecular imaging of the Nav channel β3 subunit indicates a trimeric assembly Journal Of Biological Chemistry, 289 (15) Apr 2014 DOI: 10.1074/jbc.M113.527994
Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies Biochemical Journal, 459 Apr 2014 DOI: 10.1042/BJ20131399
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy Nature, 508 (7495) Apr 2014 DOI: 10.1038/nature13194
Structural basis for translocation by AddAB helicase-nuclease and its arrest at χ sites Nature, Mar 2014 DOI: 10.1038/nature13037
Journal Paper I04-Macromolecular Crystallography
A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR Biochemical Journal, 458 Mar 2014 DOI: 10.1042/BJ20131127
Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1 Nature, 507 (7490) Mar 2014 DOI: 10.1038/nature13116
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Metabolic and target-site mechanisms combine to confer strong DDT resistance in Anopheles gambiae Plos One, 9 (3) Mar 2014 DOI: 10.1371/journal.pone.0092662
Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP) Journal Of Medicinal Chemistry, 57 (6) Mar 2014 DOI: 10.1021/jm500066b
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A range of C[epsilon]3-C[epsilon]4 interdomain angles in IgE Fc accommodate binding to its receptor CD23 Acta Crystallographica Section F Structural Biology Communications, 70 Mar 2014 DOI: 10.1107/S2053230X14003355
Structure and activity of the Streptomyces coelicolor A3(2) β-N-acetylhexosaminidase provides further insight into GH20 family catalysis and inhibition Biochemistry, 53 (11) Mar 2014 DOI: 10.1021/bi401697j
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structures of alcohol dehydrogenases from Ralstoniaand Sphingobium spp. reveal the molecular basis for their recognition of ‘bulky–bulky’ ketones Topics In Catalysis, 57 (5) Mar 2014 DOI: 10.1007/s11244-013-0191-2
Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors Journal Of Medicinal Chemistry, 57 (6) Feb 2014 DOI: 10.1021/jm401356t
Journal Paper I04-Macromolecular Crystallography
Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor Plos Pathogens, 10 (2) Feb 2014 DOI: 10.1371/journal.ppat.1003898
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Global low-frequency motions in protein allostery: CAP as a model system Biophysical Reviews , 7 (163) Feb 2014 DOI: 10.1007/s12551-015-0163-9
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase in complex with magnesium ions Plos One, 9 (2) Feb 2014 DOI: 10.1371/journal.pone.0087577
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure-based engineering and comparison of novel split inteins for protein ligation Molecular Biosystems, Feb 2014 DOI: 10.1039/c4mb00021h
Journal Paper I04-Macromolecular Crystallography
FGFR1 kinase inhibitors: close regioisomers adopt divergent binding modes and display distinct biophysical signatures Acs Medicinal Chemistry Letters, 5 (2) Feb 2014 DOI: 10.1021/ml4004205
Journal Paper I04-Macromolecular Crystallography
Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives Journal Of Medicinal Chemistry, 57 (2) Jan 2014 DOI: 10.1021/jm401665x
Origin of the proton-transfer step in the cofactor-free 1-H-3-hydroxy-4-oxoquinaldine 2,4- dioxygenase: Effect of the basicity of an active site His residue Journal Of Biological Chemistry, Jan 2014 DOI: 10.1074/jbc.M113.543033
T-cell Receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions Journal Of Biological Chemistry, 289 (2) Jan 2014 DOI: 10.1074/jbc.M113.522110
Structure of the SAS-6 cartwheel hub from Leishmania major Elife, 3 Jan 2014 DOI: 10.7554/eLife.01812
Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE) Journal Of Biological Chemistry, 289 (3) Jan 2014 DOI: 10.1074/jbc.M113.512335
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structures of complexes of a metal-independent glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-acetylgalactosamine (UDP-GalNAc) and its hydrolysis products Journal Of Biological Chemistry, Jan 2014 DOI: 10.1074/jbc.M113.545384
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure of the tetrameric fibrinogen-like recognition domain of fibrinogen C domain containing 1 (FIBCD1) protein Journal Of Biological Chemistry, 289 (5) Jan 2014 DOI: 10.1074/jbc.M113.520577
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis Proceedings Of The National Academy Of Sciences, 111 (4) Jan 2014 DOI: 10.1073/pnas.1317488111
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural and functional characterisation of human carboxylesterases Jan 2014
Thesis I03-Macromolecular Crystallography I04-Macromolecular Crystallography
- Immacolata Venditto, Helena Santos, James Sandy, Juan Sanchez-Weatherby, Luis M. A. Ferreira, Kazuo Sakka, Carlos M. G. A. Fontes, Shabir Najmudin, "Crystallization and preliminary X-ray diffraction analysis of a trimodular endo-[beta]-1,4-glucanase (Cel5B) from Bacillus halodurans", Acta Crystallographica Section F Structural Biology Communications, 70, 1628 - 1630 (2014), DOI: 10.1107/S2053230X1402319X
- Kristof Moonens, Maia De Kerpel, Annelies Coddens, Eric Cox, Els Pardon, Han Remaut, Henri De Greve, "Nanobody mediated inhibition of attachment of F18 fimbriae expressing Escherichia coli", Plos One, 9 (12) (2014), DOI: 10.1371/journal.pone.0114691
- [Thesis] Rebecca Dovega, "Structural and functional studies of proteins in cell signaling and cancer" (2014)
- Julia Steuber, Georg Vohl, Marco S. Casutt, Thomas Vorburger, Kay Diederichs, Guenter Fritz, "Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase", Nature, 516 (7529), 62 - 67 (2014), DOI: 10.1038/nature14003
- Suresh Subedi, Kristof Moonens, Ema Romão, Alvin Wei Han Lo, Guy Vandenbussche, Jeanna Bugaytsova, Serge Muyldermans, Thomas Borén, Han Remaut, "Expression, purification and X-ray crystallographic analysis of the Helicobacter pylori blood group antigen-binding adhesin BabA", Acta Crystallographica Section F Structural Biology Communications, 70, 1631 - 1635 (2014), DOI: 10.1107/S2053230X14023188
- Tom Miller, Trevor J. Rutherford, Kristian Birchall, Jasveen Chugh, Marc Fiedler, Mariann Bienz, "Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger", Acs Chemical Biology, 9 (12), 2864 - 2874 (2014), DOI: 10.1021/cb500585s
- Mark Stead, Stephanie C. Wright, "Structures of heterodimeric POZ domains of Miz1/BCL6 and Miz1/NAC1", Acta Crystallographica Section F Structural Biology Communications, 70, 1591 - 1596 (2014), DOI: 10.1107/S2053230X14023449
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