Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04 Contact
Beamline Phone Number:
+44 (0) 1235 778679
Principal Beamline Scientist:
Ralf Flaig
Tel: +44 (0) 1235 778412
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04 Microfocus MX
Status: Operational
Beamsize: 10 µm x 5 µm - 110 µm x 100 µm
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
Detector: Eiger2 XE 16M
Wavelength: 0.69 - 2.07 Å
These publications are based on data gathered on beamline I04. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
140 items found for 2015 [total: 2283]
Structural basis for specificity and promiscuity in a carrier protein/enzyme system from the sulfur cycle Proceedings Of The National Academy Of Sciences, Dec 2015 DOI: 10.1073/pnas.1506386112
Journal Paper I04-Macromolecular Crystallography
DNA recognition for virus assembly through multiple sequence-independent interactions with a helix-turn-helix motif Nucleic Acids Research, Dec 2015 DOI: 10.1093/nar/gkv1467
Comparison of the structure and activity of glycosylated and aglycosylated human carboxylesterase 1 Plos One, 10 Dec 2015 DOI: 10.1371/journal.pone.0143919
Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity Organic & Biomolecular Chemistry, Dec 2015 DOI: 10.1039/C5OB02037A
Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus Nature Communications, 6 Dec 2015 DOI: 10.1038/ncomms9884
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53 Structure, 23 (12) Dec 2015 DOI: 10.1016/j.str.2015.10.016
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
A streamlined, automated protocol for the production of milligram quantities of untagged recombinant rat lactate dehydrogenase a using ÄKTAxpressTM Plos One, 10 Dec 2015 DOI: 10.1371/journal.pone.0146164
Docking and linking of fragments to discover Jumonji histone demethylase inhibitors Journal Of Medicinal Chemistry, Dec 2015 DOI: 10.1021/acs.jmedchem.5b01527
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Selective inhibition of the mitochondrial permeability transition pore protects against neuro-degeneration in experimental multiple sclerosis Journal Of Biological Chemistry, 291 Dec 2015 DOI: 10.1074/jbc.M115.700385
Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family Nature Communications, 6 Dec 2015 DOI: 10.1038/ncomms10197
Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family Nature Communications, 6 Dec 2015 DOI: 10.1038/ncomms10172
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Crystal structure of the herpesvirus nuclear egress complex provides insights into inner nuclear membrane remodeling Cell Reports, 13 (12) Dec 2015 DOI: 10.1016/j.celrep.2015.11.008
Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex The Embo Journal, 34 Dec 2015 DOI: 10.15252/embj.201592651
Journal Paper I04-Macromolecular Crystallography
Structural studies of alpha2 macroglobulin from Limulus polyphemus Dec 2015
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure–function relationships in Gan42B, an intracellular GH42 β-galactosidase from Geobacillus stearothermophilus Acta Crystallographica Section D Biological Crystallography, 71 (12) Dec 2015 DOI: 10.1107/S1399004715018672
Journal Paper I04-Macromolecular Crystallography
Lignocellulose degradation mechanisms across the Tree of Life Current Opinion In Chemical Biology, 29 Dec 2015 DOI: 10.1016/j.cbpa.2015.10.018
Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities Chemistry & Biology, 22 Dec 2015 DOI: 10.1016/j.chembiol.2015.10.013
Journal Paper I04-Macromolecular Crystallography
Mechanism of hydrogen activation by [NiFe] hydrogenases Nature Chemical Biology, Nov 2015 DOI: 10.1038/nchembio.1976
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Application of in situ diffraction in high-throughput structure determination platforms Methods In Molecular Biology, 1261 Nov 2015 DOI: 10.1007/978-1-4939-2230-7_13
Book Chapter I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
The redox state regulates the conformation of Rv2466c to activate the antitubercular prodrug TP053 Journal Of Biological Chemistry, Nov 2015 DOI: 10.1074/jbc.M115.677039
Structure of the bacterial cell division determinant GpsB and its interaction with penicillin binding proteins Molecular Microbiology, Nov 2015 DOI: 10.1111/mmi.13279
A convenient approach to stereoisomeric iminocyclitols: generation of potent brain-permeable OGA inhibitors Angewandte Chemie International Edition, Nov 2015 DOI: 10.1002/anie.201507985
Journal Paper I04-Macromolecular Crystallography
ATM localization and heterochromatin repair depend on direct interaction of the 53BP1-BRCT2 domain with γH2AX Cell Reports, Nov 2015 DOI: 10.1016/j.celrep.2015.10.074
The role of lipids in mechanosensation Nature Structural & Molecular Biology, 22 Nov 2015 DOI: 10.1038/nsmb.3120
Journal Paper I04-Macromolecular Crystallography
Structural determinants of reductive terpene cyclization in iridoid biosynthesis Nature Chemical Biology, Nov 2015 DOI: 10.1038/nchembio.1955
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS Molecular Microbiology, 99 Nov 2015 DOI: 10.1111/mmi.13267
X-ray structure and activities of an essential Mononegavirales L-protein domain Nature Communications, 6 Nov 2015 DOI: 10.1038/ncomms9749
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for collagen recognition by the immune receptor OSCAR Blood, Nov 2015 DOI: 10.1182/blood-2015-08-667055
Journal Paper I04-Macromolecular Crystallography
Generation of a selective small molecule inhibitor of the CBP/P300 bromodomain for leukemia therapy Cancer Research, 75 Nov 2015 DOI: 10.1158/0008-5472.CAN-15-0236
Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity Bioorganic & Medicinal Chemistry, 23 (21) Nov 2015 DOI: 10.1016/j.bmc.2015.09.038
Structural insight into archaic and alternative chaperone-usher pathways reveals a novel mechanism of pilus biogenesis Plos Pathogens, 11 Nov 2015 DOI: 10.1371/journal.ppat.1005269
Natural products: biosynthesis, antimicrobial properties and protein targets Nov 2015
Thesis I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism Scientific Reports, 5 Nov 2015 DOI: 10.1038/srep17144
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural characterization of human heparanase reveals insights into substrate recognition Nature Structural & Molecular Biology, 22 Nov 2015 DOI: 10.1038/nsmb.3136
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Tripartite ATP-independent periplasmic (TRAP) transporters use an arginine-mediated selectivity filter for high affinity substrate binding Journal Of Biological Chemistry, 290 (45) Nov 2015 DOI: 10.1074/jbc.M115.656603
Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII Immunological Reviews, 268 Nov 2015 DOI: 10.1111/imr.12340
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Development of crystallographic techniques and their application to several protein targets Nov 2015
Thesis I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Crystal structure of the PepSY-containing domain of the YpeB protein involved in germination of bacillus spores Proteins: Structure, Function, And Bioinformatics, 83 (10) Oct 2015 DOI: 10.1002/prot.24868
Journal Paper I04-Macromolecular Crystallography
Structure of the dual-function fructose-1,6/sedoheptulose-1,7-bisphosphatase from Thermosynechococcus elongatus bound with sedoheptulose-7-phosphate Acta Crystallographica Section F Structural Biology Communications, 71 Oct 2015 DOI: 10.1107/S2053230X15016829
Structural insights into the MMACHC-MMADHC protein complex involved in vitamin B12 trafficking Journal Of Biological Chemistry, Oct 2015 DOI: 10.1074/jbc.M115.683268
Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain Journal Of Molecular Biology, 427 (20) Oct 2015 DOI: 10.1016/j.jmb.2015.08.023
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy Nature Chemistry, Oct 2015 DOI: 10.1038/nchem.2369
Structural dissection of the maltodextrin disproportionation cycle of the arabidopsis plastidial enzyme DPE1 Journal Of Biological Chemistry, Oct 2015 DOI: 10.1074/jbc.M115.682245
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two β-propellers during the assembly of large ribosomal subunits in eukaryotes Nucleic Acids Research, Oct 2015 DOI: 10.1093/nar/gkv1043
Crystal structures of the extracellular domain from PepT1 and PepT2 provide novel insights into mammalian peptide transport Structure, 23 (10) Oct 2015 DOI: 10.1016/j.str.2015.07.016
Journal Paper I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent Bioorganic & Medicinal Chemistry Letters, 25 (19) Oct 2015 DOI: 10.1016/j.bmcl.2015.08.003
In vacuo X-ray data collection from graphene-wrapped protein crystals Acta Crystallographica Section D Biological Crystallography, 71 (10) Oct 2015 DOI: 10.1107/S1399004715014194
Insights into collagen uptake by C-type mannose receptors from the crystal structure of Endo180 domains 1–4 Structure, Oct 2015 DOI: 10.1016/j.str.2015.09.004
Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction Plos Pathogens, 11 (10) Oct 2015 DOI: 10.1371/journal.ppat.1005194
Three aromatic residues are required for electron transfer during iron mineralization in bacterioferritin Angewandte Chemie International Edition, Oct 2015 DOI: 10.1002/anie.201507486
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Optimization of a novel binding motif to [...], a potent and orally bioavailable selective estrogen receptor downregulator and antagonist Journal Of Medicinal Chemistry, 58 (20) Oct 2015 DOI: 10.1021/acs.jmedchem.5b00984
Journal Paper I04-Macromolecular Crystallography
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus Nature, 527 (7576) Oct 2015 DOI: 10.1038/nature15525
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Evidence for a functional O-linked N-acetylglucosamine (O-GlcNAc ) system in the thermophilic bacterium Thermobaculum terrenum Journal Of Biological Chemistry, 290 Oct 2015 DOI: 10.1074/jbc.M115.689596
Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers Antimicrobial Agents And Chemotherapy, Oct 2015 DOI: 10.1128/AAC.01335-15
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis The Embo Journal, 34 Oct 2015 DOI: 10.15252/embj.201592337
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes Science, 350 Oct 2015 DOI: 10.1126/science.aac7365
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes Nature Chemical Biology, Sept 2015 DOI: 10.1038/nchembio.1926
Genetically encoded phenyl azide photochemistry drives positive and negative functional modulation of a red fluorescent protein Rsc Advances, 5 (95) Sept 2015 DOI: 10.1039/C5RA13552D
Structures of the methyltransferase component of Desulfitobacterium hafniense DCB-2 O-demethylase shed light on methyltetrahydrofolate formation Acta Crystallographica Section D Biological Crystallography, 71 Sept 2015 DOI: 10.1107/S1399004715013061
Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design Human Molecular Genetics, 24 (20) Sept 2015 DOI: 10.1093/hmg/ddv280
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Cleavage of nicotinamide adenine dinucleotide by the ribosome-inactivating protein from Momordica charantia Acta Crystallographica Section F Structural Biology Communications, 71 (9) Sept 2015 DOI: 10.1107/S2053230X15013540
The role of protein-ligand contacts in allosteric regulation f the Escherichia coli catabolite activator protein Journal Of Biological Chemistry, 290 (36) Sept 2015 DOI: 10.1074/jbc.M115.669267
Structural transitions during prothrombin activation: On the importance of fragment 2 Biochimie, Sept 2015 DOI: 10.1016/j.biochi.2015.09.013
Inflammatory signaling by NOD-RIPK2 is inhibited by clinically relevant type II kinase inhibitors Chemistry & Biology, 22 (9) Sept 2015 DOI: 10.1016/j.chembiol.2015.07.017
Crystal structures of a double-barrelled fluoride ion channel Nature, 525 (7570) Sept 2015 DOI: 10.1038/nature14981
Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors Medchemcomm, 6 (9) Sept 2015 DOI: 10.1039/C5MD00210A
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase Nature Communications, 6 Sept 2015 DOI: 10.1038/ncomms8877
Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin Acta Crystallographica Section D Biological Crystallography, 71 Sept 2015 DOI: 10.1107/S139900471500629X
Journal Paper I04-Macromolecular Crystallography
Streptococcus Pneumoniae NanC: structural insights into the specificity and mechanism of a sialidase that produces a sialidase inhibitor Journal Of Biological Chemistry, Sept 2015 DOI: 10.1074/jbc.M115.673632
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Cloning, expression, purification and crystallization of a pair of novel virulence factors, SghA and SghR, from Agrobacterium tumefaciens Acta Crystallographica Section F Structural Biology Communications, 71 (9) Sept 2015 DOI: 10.1107/S2053230X15012881
Structure of subcomplex Iβ of mammalian respiratory complex I leads to new supernumerary subunit assignments Proceedings Of The National Academy Of Sciences, 112 Sept 2015 DOI: 10.1073/pnas.1510577112
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor Elife, 4 Aug 2015 DOI: 10.7554/eLife.08709
Structures of the ultra-high-affinity protein–protein complexes of pyocins S2 and AP41 and their cognate immunity proteins from Pseudomonas aeruginosa Journal Of Molecular Biology, 427 (17) Aug 2015 DOI: 10.1016/j.jmb.2015.07.014
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Differential recognition preferences of the three Src homology 3 (SH3) domains from the adaptor CD2-associated protein (CD2AP), and direct association with Ras and Rab interactor 3 (RIN3) Journal Of Biological Chemistry, Aug 2015 DOI: 10.1074/jbc.M115.637207
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Naturally occurring mutations in the MPS1 gene predispose cells to kinase inhibitor drug resistance Cancer Research, 75 (16) Aug 2015 DOI: 10.1158/0008-5472.CAN-14-3272
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Deciphering the non-equivalence of serine and threonine o-glycosylation points: implications for molecular recognition of the Tn antigen by an anti-MUC1 antibody Angewandte Chemie International Edition, 54 (34) Aug 2015 DOI: 10.1002/anie.201502813
Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3 Journal Of Structural Biology, 191 (2) Aug 2015 DOI: 10.1016/j.jsb.2015.05.008
A native ternary complex trapped in a crystal reveals the catalytic mechanism of a retaining glycosyltransferase Angewandte Chemie International Edition, 54 (34) Aug 2015 DOI: 10.1002/anie.201504617
Structures of the RNA polymerase-σ54 reveal new and conserved regulatory strategies Science, 349 (6250) Aug 2015 DOI: 10.1126/science.aab1478
Diversity in the structures and ligand binding sites of nematode fatty acid and retinol binding proteins revealed by Na-FAR-1 from Necator americanus Biochemical Journal, Aug 2015 DOI: 10.1042/BJ20150068
Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase Medchemcomm, Aug 2015 DOI: 10.1039/C5MD00242G
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Modular design of self-assembling peptide-based nanotubes Journal Of The American Chemical Society, 137 (33) Aug 2015 DOI: 10.1021/jacs.5b03973
Structural studies of the Dickeya dadantii type II secretion system protein GspB Aug 2015
Thesis I04-Macromolecular Crystallography
Mechanism of phospho-ubiquitin-induced PARKIN activation Nature, 524 (7565) Aug 2015 DOI: 10.1038/nature14879
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Structural basis of Lewisb antigen binding by the Helicobacter pylori adhesin BabA Science Advances, 1 Aug 2015 DOI: 10.1126/sciadv.1500315
From bacterial to human dihydrouridine synthase: automated structure determination Acta Crystallographica Section D Biological Crystallography, 71 (7) Jul 2015 DOI: 10.1107/S1399004715009220
Redox linked flavin sites in extracellular decaheme proteins involved in microbe-mineral electron transfer Scientific Reports, 5 Jul 2015 DOI: 10.1038/srep11677
Fragment-based discovery of low-micromolar ATAD2 bromodomain inhibitors Journal Of Medicinal Chemistry, 58 (14) Jul 2015 DOI: 10.1021/acs.jmedchem.5b00772
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan Elife, 4 Jul 2015 DOI: 10.7554/eLife.06554
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural characterization of the principal mRNA-export factor Mex67–Mtr2 from Chaetomium thermophilum Acta Crystallographica Section F Structural Biology Communications, 71 (7) Jul 2015 DOI: 10.1107/S2053230X15008766
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Small-molecule transport by CarO, an abundant eight-stranded β-barrel outer membrane protein from Acinetobacter baumannii Journal Of Molecular Biology, 427 (14) Jul 2015 DOI: 10.1016/j.jmb.2015.03.016
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone Chemical Communications, 51 (52) Jul 2015 DOI: 10.1039/C5CC01816A
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains Nature Structural & Molecular Biology, 22 (8) Jul 2015 DOI: 10.1038/nsmb.3052
Journal Paper I04-Macromolecular Crystallography
Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein Nature Communications, 6 June 2015 DOI: 10.1038/ncomms8271
An internal thioester in a pathogen surface protein mediates covalent host binding Elife, 4 June 2015 DOI: 10.7554/eLife.06638
Purification, crystallization and preliminary X-ray diffraction analysis of the Escherichia coli common pilus chaperone EcpB Acta Crystallographica Section F Structural Biology Communications, 71 (6) June 2015 DOI: 10.1107/S2053230X15006354
The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation Elife, 4 May 2015 DOI: 10.7554/eLife.07410
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Structure of a bacterial toxin-activating acyltransferase Proceedings Of The National Academy Of Sciences, May 2015 DOI: 10.1073/pnas.1503832112
Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases Proceedings Of The National Academy Of Sciences, 112 (19) May 2015 DOI: 10.1073/pnas.1500161112
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structural studies of a thermophilic esterase from a new Planctomycetes species, Thermogutta terrifontis Febs Journal, 282 (15) May 2015 DOI: 10.1111/febs.13326
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural and kinetic characterization of thymidine kinase from Leishmania major Plos Neglected Tropical Diseases, 9 (5) May 2015 DOI: 10.1371/journal.pntd.0003781
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor Angewandte Chemie International Edition, 54 (21) May 2015 DOI: 10.1002/anie.201501394
Journal Paper I02-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein Nature Structural & Molecular Biology, 22 (6) May 2015 DOI: 10.1038/nsmb.3016
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly Acta Crystallographica Section F Structural Biology Communications, 71 (5) May 2015 DOI: 10.1107/S2053230X15000990
Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes Chemical Science, 6 (6) Apr 2015 DOI: 10.1039/C5SC00913H
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx Cell Host & Microbe, 17 (4) Apr 2015 DOI: 10.1016/j.chom.2015.03.004
Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding Elife, 4 Apr 2015 DOI: 10.7554/eLife.05345
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition Journal Of Medicinal Chemistry, 59 Apr 2015 DOI: 10.1021/acs.jmedchem.5b00256
Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases Structure, 23 (4) Apr 2015 DOI: 10.1016/j.str.2015.01.014
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structures of the Ets protein DNA-binding domains of transcription factors Etv1, Etv4, Etv5, and Fev: determinants of DNA binding and redox regulation by disulfide bond formation Journal Of Biological Chemistry, Apr 2015 DOI: 10.1074/jbc.M115.646737
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures Proceedings Of The National Academy Of Sciences, 112 (14) Apr 2015 DOI: 10.1073/pnas.1417594112
Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus Proceedings Of The National Academy Of Sciences, 112 (17) Apr 2015 DOI: 10.1073/pnas.1501690112
Cell-surface attachment of bacterial multienzyme complexes involves highly dynamic protein-protein anchors Journal Of Biological Chemistry, 290 (21) Apr 2015 DOI: 10.1074/jbc.M114.633339
Molecular mechanism of flocculation self-recognition in yeast and its role in mating and survival Mbio, 6 (2) Apr 2015 DOI: 10.1128/mBio.00427-15
Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy Human Molecular Genetics, 24 (9) Apr 2015 DOI: 10.1093/hmg/ddv007
Crystal structure of a hidden protein, YcaC, a putative cysteine hydrolase from pseudomonas aeruginosa, with and without an acrylamide adduct International Journal Of Molecular Sciences, 16 (7) Apr 2015 DOI: 10.3390/ijms160715971
Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain Biochemical Journal, Mar 2015 DOI: 10.1042/BJ20150039
X-ray, spectroscopic and normal-mode dynamics of calexcitin: structure–function studies of a neuronal calcium-signalling protein Acta Crystallographica Section D Biological Crystallography, 71 Mar 2015 DOI: 10.1107/S1399004714026704
Journal Paper I04-Macromolecular Crystallography
Improved crystallization and diffraction of caffeine-induced death suppressor protein 1 (Cid1) Acta Crystallographica Section F Structural Biology Communications, 71 (3) Mar 2015 DOI: 10.1107/S2053230X15001351
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide Acta Crystallographica Section F Structural Biology Communications, 71 (3) Mar 2015 DOI: 10.1107/S2053230X15001065
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Investigation of (E)-3-[4-(2-oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic acids as oral selective estrogen receptor down-regulators Journal Of Medicinal Chemistry, 58 (8) Mar 2015 DOI: 10.1021/acs.jmedchem.5b00066
Journal Paper I04-Macromolecular Crystallography
Coagulation factor XII protease domain crystal structure Journal Of Thrombosis And Haemostasis, Mar 2015 DOI: 10.1111/jth.12849
Structures of the Apo and FAD-bound forms of 2-hydroxybiphenyl 3-monooxygenase (HbpA) locate activity hotspots identified by using directed evolution Chembiochem, Mar 2015 DOI: 10.1002/cbic.201402701
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Activation of a primed RING E3-E2–ubiquitin complex by non-covalent ubiquitin Molecular Cell, 58 Mar 2015 DOI: 10.1016/j.molcel.2015.02.017
The crystal structure of the human titin: obscurin complex reveals a conserved yet specific muscle M-band zipper module Journal Of Molecular Biology, 427 (4) Feb 2015 DOI: 10.1016/j.jmb.2014.11.019
Journal Paper I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Family 46 Carbohydrate-Binding Modules contribute to the enzymatic hydrolysis of xyloglucan and beta-1,3-1,4-glucans through distinct mechanisms Journal Of Biological Chemistry, Feb 2015 DOI: 10.1074/jbc.M115.637827
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The role of monovalent cations in the ATPase reaction of DNA gyrase Acta Crystallographica Section D, 71 Feb 2015 DOI: 10.1107/S1399004715002916
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A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape Retrovirology, 12 Feb 2015 DOI: 10.1186/s12977-015-0149-5
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Notum deacylates Wnt proteins to suppress signalling activity Nature, 519 (7542) Feb 2015 DOI: 10.1038/nature14259
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Crystallization and preliminary crystallographic analysis of the putative sugar-binding protein Msmeg_0515 (AgaE) from Acta Crystallographica Section F Structural Biology Communications, 71 Feb 2015 DOI: 10.1107/S2053230X15000035
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Bactobolin A binds to a site on the 70S ribosome distinct from previously seen antibiotics Journal Of Molecular Biology, 427 (4) Feb 2015 DOI: 10.1016/j.jmb.2014.12.018
Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC Structure, 23 (1) Jan 2015 DOI: 10.1016/j.str.2014.10.017
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Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 Proceedings Of The National Academy Of Sciences, 112 (3) Jan 2015 DOI: 10.1073/pnas.1416611112
Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum Neuron, 85 (2) Jan 2015 DOI: 10.1016/j.neuron.2014.12.020
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Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria Cell Host & Microbe, 17 (1) Jan 2015 DOI: 10.1016/j.chom.2014.11.007
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Structural basis for the interaction of protein S1 with the Escherichia coli ribosome Nucleic Acids Research, 43 (1) Jan 2015 DOI: 10.1093/nar/gku1314
Understanding cell signalling systems: paving the way for new therapies Philosophical Transactions Of The Royal Society A: Mathematical, Physical And Engineering Sciences, 373 Jan 2015 DOI: 10.1098/rsta.2013.0155
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Flexibility and structural conservation in a c-KIT G-quadruplex Nucleic Acids Research, 43 Jan 2015 DOI: 10.1093/nar/gku1282
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