Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy B21 Contact
Beamline phone numbers:
+44 (0) 1235 77 8627
+44 (0) 1235 77 8640
Principal Beamline Scientist:
Nathan Cowieson
Tel: +44 (0) 1235 567 504
E-mail: [email protected]
Science Group Leader
Robert Rambo
Email: [email protected]
Tel: +44 (0)1235 56 7675
B21 High Throughput SAXS
Status: Operational
Beamsize: <75 μm
Detector: Eiger 4M
Energy: 6 - 23 keV
Detector: Eiger 4M
Energy: 6 - 23 keV
78 items found for 2025 [total: 654]
Elucidating β-sheet ordering in lipopeptides bearing lysine-rich tripeptide sequences: fibrils versus nanotapes The Journal Of Physical Chemistry B, Dec 2025 DOI: 10.1021/acs.jpcb.5c06441
Synaptonemal complex assembly in yeast depends on a 2:2 Ecm11-Gmc2 heterocomplex Open Biology, 15 Dec 2025 DOI: 10.1098/rsob.250288
Concentrated rhamnolipid formulations: bridging chemodiversity to structure, flow behavior, and functionality Acs Sustainable Chemistry & Engineering, Dec 2025 DOI: 10.1021/acssuschemeng.5c09437
Structural basis of microtubule-mediated signal transduction Cell, 5 Dec 2025 DOI: 10.1016/j.cell.2025.11.011
Investigating the effects of chelating agents, surfactants and magnesium cations on the size of LPS aggregates in formulations causing low endotoxin recovery in limulus amebocyte lysate assays European Journal Of Pharmaceutics And Biopharmaceutics, 180 Nov 2025 DOI: 10.1016/j.ejpb.2025.114861
Allergen-induced structural rearrangements in IgE: insights from SAXS and molecular dynamics International Journal Of Biological Macromolecules, 77 Nov 2025 DOI: 10.1016/j.ijbiomac.2025.147658
Understanding mechanisms of nuclear transport during viral infection Nov 2025
Thesis B21-High Throughput SAXS I04-Macromolecular Crystallography
Generating cell surface nucleated hydrogels with an artificial membrane-binding transglutaminase Advanced Functional Materials, Nov 2025 DOI: 10.1002/adfm.202519196
Odoribacter splanchnicus Lipooligosaccharide: an uncommon structure with weak immunostimulatory activity Chemical Science, Nov 2025 DOI: 10.1039/D5SC08335D
Structural determination of self-assembled aggregates formed by a therapeutic cyclical peptide and an ionic surfactant in aqueous solution Journal Of Colloid And Interface Science, 704 Nov 2025 DOI: 10.1016/j.jcis.2025.139373
Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel Nature Communications, 16 Nov 2025 DOI: 10.1038/s41467-025-64982-y
Journal Paper B21-High Throughput SAXS labSAXS-Offline SAXS and Sample Environment Development open access
Dissecting the molecular basis underlying mycobacterial cell-wall hydrolysis by the catalytic domains of D29LysA and DS6ALysA phage endolysins International Journal Of Biological Macromolecules, Nov 2025 DOI: 10.1016/j.ijbiomac.2025.148896
The structure and function of extracellular redox enzymes Nov 2025
Thesis B21-High Throughput SAXS I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Redox-dependent activity and thioredoxin interaction of cyclophilin TgCyp21 from Toxoplasma gondii International Journal Of Biological Macromolecules, 330 Nov 2025 DOI: 10.1016/j.ijbiomac.2025.148019
Fibrillization versus coacervation in arginine-tryptophan repeat peptides: effects of sequence length and pH Materials Advances, Oct 2025 DOI: 10.1039/D5MA01006C
Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2 Rsc Chemical Biology, Oct 2025 DOI: 10.1039/D5CB00177C
A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum Molecular Cell, Oct 2025 DOI: 10.1016/j.molcel.2025.09.032
Dissecting the RAD51–BRC4 interaction landscape through integrative molecular simulations and experimental biophysics Journal Of Chemical Information And Modeling, Oct 2025 DOI: 10.1021/acs.jcim.5c01639
Structure and analysis of a virulent chitinase from Listeria monocytogenes Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, 1874 Oct 2025 DOI: 10.1016/j.bbapap.2025.141106
Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study Scientific Reports, 15 Oct 2025 DOI: 10.1038/s41598-025-20945-3
EXPECT: A thermosensitive embedded bioprinting platform for guided spatial cell organization Smart Materials In Medicine, 30 Sept 2025 DOI: 10.1016/j.smaim.2025.09.002
Capsular polysaccharide from Psychrobacter sp. TAE2020: An unusual amino sugar-enriched macromolecule with anti-biofilm and emulsification activities Carbohydrate Polymers, 105 Sept 2025 DOI: 10.1016/j.carbpol.2025.124484
Journal Paper B21-High Throughput SAXS
Structural dynamics of dengue virus UTRs and their cyclization Biophysical Journal, Sept 2025 DOI: 10.1016/j.bpj.2025.09.004
Effect of C-terminal residue on the phase behavior and properties of β-sheet forming self-assembling peptide hydrogels Biomacromolecules, Sept 2025 DOI: 10.1021/acs.biomac.5c01348
Journal Paper B21-High Throughput SAXS
Comparison of the self-assembly and conformations of glucose- and galactose-based glycopyranosides in dilute aqueous solution Langmuir, 274 Sept 2025 DOI: 10.1021/acs.langmuir.5c02346
Nonclassical nucleation via mesoscale clusters in crystallisation of polymorphic active pharmaceutical ingredients Sept 2025 DOI: 10.34961/18750
Thesis B21-High Throughput SAXS
Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment Frontiers In Pharmacology, 16 Sept 2025 DOI: 10.3389/fphar.2025.1667210
Novel SARS-CoV-2 allosteric inhibitors that destabilize the Main Protease Mpro dimer International Journal Of Biological Macromolecules, 319 Aug 2025 DOI: 10.1016/j.ijbiomac.2025.145162
Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations Nature Communications, 16 Aug 2025 DOI: 10.1038/s41467-025-62923-3
Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP Nature Communications, 16 Aug 2025 DOI: 10.1038/s41467-025-62068-3
Phase behavior of light-responsive lyotropic liquid crystals for molecular solar thermal energy storage Journal Of The American Chemical Society, 15 Aug 2025 DOI: 10.1021/jacs.5c09267
A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1 Journal Of Cell Biology, 224 Aug 2025 DOI: 10.1083/jcb.202408025
Journal Paper B21-High Throughput SAXS
A small-angle scattering structural characterisation of regular versus gluten-free spaghetti Food Hydrocolloids, 136 Aug 2025 DOI: 10.1016/j.foodhyd.2025.111855
Journal Paper B21-High Throughput SAXS
Human FASTK preferentially binds single‐stranded and G‐rich RNA The Febs Journal, 45 Jul 2025 DOI: 10.1111/febs.70155
Crystal structure of coagulation factor XII N-terminal domains 1–5 Acta Crystallographica Section D Structural Biology, 81 Jul 2025 DOI: 10.1107/S2059798325005297
Molecular basis of Fab-dependent IgA antibody recognition by gut-bacterial metallopeptidases The Embo Journal, 630 Jul 2025 DOI: 10.1038/s44318-025-00518-w
Collapse of lipid membranes into distended lipidic cubic phases at high solvent levels, membrane remodelling, and self-repair Journal Of The American Chemical Society, Jul 2025 DOI: 10.1021/jacs.5c07146
The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases Nature Communications, 16 Jul 2025 DOI: 10.1038/s41467-025-60986-w
Modular salt-induced nanostructures formed by a functionalized dipeptide system Matter, 142 Jul 2025 DOI: 10.1016/j.matt.2025.102334
Solution structure determination and biophysical studies of 7SK RNP and 7SL SRP RNAs Rna, Jul 2025 DOI: 10.1261/rna.080414.125
Journal Paper B21-High Throughput SAXS
Enhancing sustainability in cross-linkable block copolymer formulations Jul 2025 DOI: 10.48780/publications.aston.ac.uk.00047845
Thesis B21-High Throughput SAXS
Recycling spent synthesis liquor for enhanced production of ZIF-67: characterization and morphological insights Chemnanomat, 57 June 2025 DOI: 10.1002/cnma.202500100
Enterohaemorrhagic Escherichia coli AdhE spirosome length correlates with enzymatic directionality and is perturbed by salicylidene acylhydrazides Open Biology, 15 June 2025 DOI: 10.1098/rsob.250041
Impact of solvent and ligand density on the self-assembly and optical properties of metal nanocrystals Nanoscale, 16 June 2025 DOI: 10.1039/D5NR01560J
Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation Nucleic Acids Research, 53 June 2025 DOI: 10.1093/nar/gkaf502
Information theory optimization of signals from small angle scattering measurements Biophysical Journal, June 2025 DOI: 10.1016/j.bpj.2025.06.031
The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarization with K+ efflux Plos Pathogens, 21 June 2025 DOI: 10.1371/journal.ppat.1012981
Influence of cholesterol on the insertion and interaction of SARS-CoV-2 proteins with lipid membranes Acs Applied Bio Materials, 924 June 2025 DOI: 10.1021/acsabm.5c00776
Discovery of functional factorless internal ribosome entry site-like structures through virome mining Plos Pathogens, 21 June 2025 DOI: 10.1371/journal.ppat.1013255
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency Proceedings Of The National Academy Of Sciences, 122 June 2025 DOI: 10.1073/pnas.2425781122
Alu RNA pseudoknot alterations influence SRP9/SRP14 association Rna, May 2025 DOI: 10.1261/rna.080359.124
Journal Paper B21-High Throughput SAXS
Structural enzymological studies of the long chain fatty acyl-CoA synthetase FadD5 from the mce1 operon of Mycobacterium tuberculosis Biochemical And Biophysical Research Communications, 148 May 2025 DOI: 10.1016/j.bbrc.2025.151960
Controlling asymmetry in supramolecular polymer systems May 2025
Thesis B21-High Throughput SAXS
Amplification of asymmetry via structural transitions in supramolecular polymer-surfactant coassemblies Journal Of The American Chemical Society, May 2025 DOI: 10.1021/jacs.5c04047
The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis The Febs Journal, 139 May 2025 DOI: 10.1111/febs.70120
Semaglutide aggregates into oligomeric micelles and short fibrils in aqueous solution Biomacromolecules, May 2025 DOI: 10.1021/acs.biomac.5c00342
Journal Paper B21-High Throughput SAXS labSAXS-Offline SAXS and Sample Environment Development open access
Development and characterization of fluorescent nanosystems for the visualization of activated complement fragments May 2025
Thesis B21-High Throughput SAXS
Transparent diblock copolymer nanoparticle dispersions via efficient RAFT emulsion polymerisation in ionic liquid Polymer Chemistry, 117 May 2025 DOI: 10.1039/D5PY00076A
Iron-sensing and redox properties of the hemerythrin-like domains of Arabidopsis BRUTUS and BRUTUS-LIKE2 proteins Nature Communications, 16 Apr 2025 DOI: 10.1038/s41467-025-58853-9
Integrative structural analysis of NF45–NF90 heterodimers reveals architectural rearrangements and oligomerization on binding dsRNA Nucleic Acids Research, 53 Apr 2025 DOI: 10.1093/nar/gkaf204
Self-assembly of toll-like receptor (TLR2/6) agonist lipidated amino acid or peptide conjugates: distinct morphologies and bioactivities Bioconjugate Chemistry, 114 Apr 2025 DOI: 10.1021/acs.bioconjchem.5c00051
Effect of tyrosine-containing self-assembling β-sheet peptides on macrophage polarization and inflammatory response Acs Applied Materials & Interfaces, Apr 2025 DOI: 10.1021/acsami.4c19900
Temperature- and time-dependent evolution of hydrogel network formed by thermoresponsive BCACB pentablock terpolymers: effect of composition Polymer, 5 Apr 2025 DOI: 10.1016/j.polymer.2025.128426
Enhancing pesticide detection: The role of serine in lipopeptide nanostructures and their self-assembly dynamics Journal Of Colloid And Interface Science, 43 Mar 2025 DOI: 10.1016/j.jcis.2025.137271
Journal Paper B21-High Throughput SAXS
Phospholipase A2 induces structural changes in phospholipid-containing cubosomes Colloids And Surfaces A: Physicochemical And Engineering Aspects, 25 Mar 2025 DOI: 10.1016/j.colsurfa.2025.136604
Thermally driven dynamic behaviors in polymeric vesicles Small, Mar 2025 DOI: 10.1002/smll.202411220
Inter-domain interactions slow BoNT/A’s onset of action Journal Of Structural Biology, 25 Mar 2025 DOI: 10.1016/j.jsb.2025.108171
Self-assembly of a conjugate of lipoic acid with a collagen-stimulating pentapeptide showing cytocompatibility and wound healing properties, and chemical and photolytic disassembly Journal Of Peptide Science, 31 Mar 2025 DOI: 10.1002/psc.70002
Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends Journal Of Cell Biology, 224 Mar 2025 DOI: 10.1083/jcb.202406061
Plasmin cleavage of beta-2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies Journal Of Thrombosis And Haemostasis, Feb 2025 DOI: 10.1016/j.jtha.2025.02.015
Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel Proceedings Of The National Academy Of Sciences, 122 Feb 2025 DOI: 10.1073/pnas.2421623122
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Harnessing light-responsive structural control in surfactant assemblies Feb 2025 DOI: 10.17863/CAM.115838
Thesis B21-High Throughput SAXS
Unraveling the atomistic mechanism of electrostatic lateral association of peptide β-sheet structures and its role in nanofiber growth and hydrogelation Small, Jan 2025 DOI: 10.1002/smll.202408213
Interplay of p23 with FKBP51 and their chaperone complex in regulating tau aggregation Nature Communications, 16 Jan 2025 DOI: 10.1038/s41467-025-56028-0
Phase separation of a microtubule plus-end tracking protein into a fluid fractal network Nature Communications, 16 Jan 2025 DOI: 10.1038/s41467-025-56468-8
Suppressing Tymovirus replication in plants using a variant of ubiquitin Plos Pathogens, 21 Jan 2025 DOI: 10.1371/journal.ppat.1012899
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix Matrix Biology, 57 Jan 2025 DOI: 10.1016/j.matbio.2025.01.002
Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) Krios IV-Titan Krios IV at Diamond open access
A novel route to ionogels using polymerisation-induced self-assembly in ionic liquid Jan 2025 DOI: 10.48780/publications.aston.ac.uk.00047182
Thesis B21-High Throughput SAXS
- Ian W. Hamley, Valeria Castelletto, Mario Tagliazucchi, "Elucidating β-sheet ordering in lipopeptides bearing lysine-rich tripeptide sequences: fibrils versus nanotapes", The Journal Of Physical Chemistry B (2025), DOI: 10.1021/acs.jpcb.5c06441
- Chandni Ravindan Otter, Owen R. Davies, Amy J. Macqueen, "Synaptonemal complex assembly in yeast depends on a 2:2 Ecm11-Gmc2 heterocomplex", Open Biology, 15 (2025), DOI: 10.1098/rsob.250288
- Matilde Tancredi, Carlo Carandente Coscia, Michela Buonocore, Alessandro Cangiano, Maria Michela Salvatore, Lorenzo Veronico, Delia Picone, Anna Maria D'Ursi, Manuela Grimaldi, Maria Francesca Ottaviani, Stefano Guido, Luigi Paduano, Luigi Gentile, Gerardino D'Errico, "Concentrated rhamnolipid formulations: bridging chemodiversity to structure, flow behavior, and functionality", Acs Sustainable Chemistry & Engineering (2025), DOI: 10.1021/acssuschemeng.5c09437
- Sung Ryul Choi, Thorsten B. Blum, Matteo Giono, Bibhas Roy, Ioannis Vakonakis, Dominic Schmid, Nicole Oelgarth, Apisha Ranganathan, Alvar D. Gossert, G. V. Shivashankar, Alfred Zippelius, Michel O. Steinmetz, "Structural basis of microtubule-mediated signal transduction", Cell, 5 (2025), DOI: 10.1016/j.cell.2025.11.011
- Amy Gorman, Mark Becker, Clair Baldock, Stephanie Moore, Alexander P. Golovanov, "Investigating the effects of chelating agents, surfactants and magnesium cations on the size of LPS aggregates in formulations causing low endotoxin recovery in limulus amebocyte lysate assays", European Journal Of Pharmaceutics And Biopharmaceutics, 180 (2025), DOI: 10.1016/j.ejpb.2025.114861
- Homero Gómez-Velasco, Benjamín García-Ramírez, Dritan Siliqi, Melissa A. Graewert, Adrián Quintero-Martinez, Enrique Ortega, Adela Rodríguez-Romero, "Allergen-induced structural rearrangements in IgE: insights from SAXS and molecular dynamics", International Journal Of Biological Macromolecules, 77 (2025), DOI: 10.1016/j.ijbiomac.2025.147658
- [Thesis] Emily Cross, "Understanding mechanisms of nuclear transport during viral infection" (2025)
- Rosalia Cuahtecontzi Delint, Tao Li, Kapil D. Patel, Will H. Zhang, Ben M. Carter, Graham J. Day, Adam W. Perriman, "Generating cell surface nucleated hydrogels with an artificial membrane-binding transglutaminase", Advanced Functional Materials (2025), DOI: 10.1002/adfm.202519196
- Marta Tiemblo Martín, Marcello Mercogliano, Kaisa Hiippala, Luca De Simone Carone, María Asunción Campanero-Rhodes, Maria Masiello, Alessandro Cangiano, Antonio Molinaro, Luigi Paduano, Dolores Solís, Reetta Satokari, Flaviana Di Lorenzo, Alba Silipo, "Odoribacter splanchnicus Lipooligosaccharide: an uncommon structure with weak immunostimulatory activity", Chemical Science (2025), DOI: 10.1039/D5SC08335D
- Ellen Brunzell, Yumi Kim Högström, Marcos López Hernández, Jan Skov Pedersen, L. Magnus Bergström, "Structural determination of self-assembled aggregates formed by a therapeutic cyclical peptide and an ionic surfactant in aqueous solution", Journal Of Colloid And Interface Science, 704 (2025), DOI: 10.1016/j.jcis.2025.139373
- Abshar Hasan, Andrey Chuvilin, Alexander Van Teijlingen, Helena Rouco, Christopher Parmenter, Federica Venturi, Michael Fay, Gabriele Greco, Nicola M. Pugno, Jan Ruben, Charlotte J. C. Edwards-Gayle, Benjamin Myers, Ingrid Dreveny, Nathan Cowieson, Adam Winter, Sara Gamea, X. Frank Walboomers, Tanvir Hussain, José Carlos Rodríguez-Cabello, Frankie Rawson, Tell Tuttle, Sherif Elsharkawy, Avijit Banerjee, Stefan Habelitz, Alvaro Mata, "Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-64982-y
- Fernando Ceballos-Zúñiga, Laura Galvez-Larrosa, Ines G. Munoz, Lourdes Infantes, Juan Fernández-Carrillo, Inmaculada Perez-Dorado, "Dissecting the molecular basis underlying mycobacterial cell-wall hydrolysis by the catalytic domains of D29LysA and DS6ALysA phage endolysins", International Journal Of Biological Macromolecules (2025), DOI: 10.1016/j.ijbiomac.2025.148896
- [Thesis] Benjamin W. Nash, "The structure and function of extracellular redox enzymes" (2025)
- Filippo Favretto, Silvia Fruncillo, Eva Jiménez-Faraco, Nicola Masè, Paola Dominici, Uxía P. De José, Ines G. Munoz, Juan A. Hermoso, Alessandra Astegno, "Redox-dependent activity and thioredoxin interaction of cyclophilin TgCyp21 from Toxoplasma gondii", International Journal Of Biological Macromolecules, 330 (2025), DOI: 10.1016/j.ijbiomac.2025.148019
- Ian W. Hamley, Valeria Castelletto, Lucas R. De Mello, Jani Seitsonen, "Fibrillization versus coacervation in arginine-tryptophan repeat peptides: effects of sequence length and pH", Materials Advances (2025), DOI: 10.1039/D5MA01006C
- Cassandra R. Kennedy, Katherine A. Mcphie, Aini Vuorinen, Jane Dudley-Fraser, Diego Esposito, Sarah Maslen, William J. Mccarthy, Jonathan Pettinger, J. Mark Skehel, David House, Katrin Rittinger, Jacob Bush, "Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2", Rsc Chemical Biology (2025), DOI: 10.1039/D5CB00177C
- Lisa Neidhardt, Joanne Tung, Miriam Kuchersky, Jakub Milczarek, Vasileios Kargas, Katherine Stott, Rina Rosenzweig, David Ron, Yahui Yan, "A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum", Molecular Cell (2025), DOI: 10.1016/j.molcel.2025.09.032
- Matteo Masetti, Mattia Bernetti, Veronica Bresciani, Francesco Rinaldi, Pedro Franco, Stefania Girotto, Andrea Cavalli, Julian D. Langer, "Dissecting the RAD51–BRC4 interaction landscape through integrative molecular simulations and experimental biophysics", Journal Of Chemical Information And Modeling (2025), DOI: 10.1021/acs.jcim.5c01639
- Saima Rehman, Maria Baczynska, Beichang Zhang, Christian D. Lorenz, James A. Garnett, "Structure and analysis of a virulent chitinase from Listeria monocytogenes", Biochimica Et Biophysica Acta (bba) - Proteins And Proteomics, 1874 (2025), DOI: 10.1016/j.bbapap.2025.141106
- Mariangela Rosa, Elisabetta Rosa, Valeria Castelletto, Ian W. Hamley, Giancarlo Morelli, Antonella Accardo, Carlo Diaferia, "Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study", Scientific Reports, 15 (2025), DOI: 10.1038/s41598-025-20945-3
- Athanasia Pylostomou, Jacek K. Wychowaniec, Riccardo Tognato, Sarah T. Egger, Gion U. Alig, Charlotte J. C. Edwards-Gayle, Fatemeh Safari, Jennifer R. Weiser, Dagnija Loca, Matteo D'Este, Tiziano Serra, Andrea J. Vernengo, "EXPECT: A thermosensitive embedded bioprinting platform for guided spatial cell organization", Smart Materials In Medicine, 30 (2025), DOI: 10.1016/j.smaim.2025.09.002
- Raffaele D'Amico, Angela Casillo, Diana Olimpo, Noemi Gallucci, Caterina D'Angelo, Maria Luisa Tutino, Luigi Paduano, Ermenegilda Parrilli, Maria Michela Corsaro, "Capsular polysaccharide from Psychrobacter sp. TAE2020: An unusual amino sugar-enriched macromolecule with anti-biofilm and emulsification activities", Carbohydrate Polymers, 105 (2025), DOI: 10.1016/j.carbpol.2025.124484
- Zachary E. Robinson, Higor Sette Pereira, Michael H. D'Souza, Trushar R. Patel, "Structural dynamics of dengue virus UTRs and their cyclization", Biophysical Journal (2025), DOI: 10.1016/j.bpj.2025.09.004
- Nastaran Zoghi, Chao-Yu Yang, Richard Bryce, Aline F. Miller, Alberto Saiani, "Effect of C-terminal residue on the phase behavior and properties of β-sheet forming self-assembling peptide hydrogels", Biomacromolecules (2025), DOI: 10.1021/acs.biomac.5c01348
- Ian W. Hamley, Anindyasundar Adak, Valeria Castelletto, Jani Seitsonen, "Comparison of the self-assembly and conformations of glucose- and galactose-based glycopyranosides in dilute aqueous solution", Langmuir, 274 (2025), DOI: 10.1021/acs.langmuir.5c02346
- [Thesis] Harsh Barua, "Nonclassical nucleation via mesoscale clusters in crystallisation of polymorphic active pharmaceutical ingredients" (2025), DOI: 10.34961/18750
- Nicole G. Metzendorf, Inga Petersen, Greta Hultqvist, "Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment", Frontiers In Pharmacology, 16 (2025), DOI: 10.3389/fphar.2025.1667210
- Beatrice Mercorelli, Alessandro Bazzacco, Michela Eleuteri, Samuele Di Cristofano, Jenny Desantis, Alessandro Paciaroni, Maria Grazia Ortore, Sara Tuci, Francesco Spinozzi, Domenico Raimondo, Laura Goracci, Gabriele Cruciani, Arianna Loregian, "Novel SARS-CoV-2 allosteric inhibitors that destabilize the Main Protease Mpro dimer", International Journal Of Biological Macromolecules, 319 (2025), DOI: 10.1016/j.ijbiomac.2025.145162
- Alan R. F. Godwin, Mark H. Becker, Rana Dajani, Matthew Snee, Alan M. Roseman, Clair Baldock, "Collagen VI microfibril structure reveals mechanism for molecular assembly and clustering of inherited pathogenic mutations", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-62923-3
- Sagar Batra, Francisco Olmo, Timothy J. Ragan, Merve Kaplan, Valeria Calvaresi, Asger Meldgaard Frank, Claudia Lancey, Mahya Assadipapari, Cuifeng Ying, Weston B. Struwe, Emma L. Hesketh, Lea Barfod, Ivan Campeotto, John M. Kelly, "Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-62068-3
- Beatrice E. Jones, Zhihang Wang, Martijn A. Zwijnenburg, Charlotte J. C. Edwards-Gayle, Kasper Moth-Poulsen, Nathan Cowieson, Rachel C. Evans, "Phase behavior of light-responsive lyotropic liquid crystals for molecular solar thermal energy storage", Journal Of The American Chemical Society, 15 (2025), DOI: 10.1021/jacs.5c09267
- Joanna Koszela, Anne Rintala-Dempsey, Giulia Salzano, Viveka Pimenta, Outi Kamarainen, Mads Gabrielsen, Aasna L. Parui, Gary S. Shaw, Helen Walden, "A substrate-interacting region of Parkin directs ubiquitination of the mitochondrial GTPase Miro1", Journal Of Cell Biology, 224 (2025), DOI: 10.1083/jcb.202408025
- J. E. Houston, R. Schweins, N. P. Cowieson, G. N. Smith, A. Scotti, "A small-angle scattering structural characterisation of regular versus gluten-free spaghetti", Food Hydrocolloids, 136 (2025), DOI: 10.1016/j.foodhyd.2025.111855
- Daria M. Dawidziak, Dawid A. Dzadz, Mikołaj I. Kuska, Madhuri Kanavalli, Maria M. Klimecka, Matthew Merski, Katarzyna J. Bandyra, Maria W. Gorna, "Human FASTK preferentially binds single‐stranded and G‐rich RNA", The Febs Journal, 45 (2025), DOI: 10.1111/febs.70155
- Muhammad Saleem, Chan Li, Bubacarr G. Kaira, Alexander K. Brown, Monika Pathak, Shabir Najmudin, Nathan Cowieson, Ingrid Dreveny, Clare Wilson, Aleksandr Shamanaev, David Gailani, Stephanie A. Smith, James H. Morrissey, Helen Philippou, Jonas Emsley, "Crystal structure of coagulation factor XII N-terminal domains 1–5", Acta Crystallographica Section D Structural Biology, 81, 380 - 393 (2025), DOI: 10.1107/S2059798325005297
- María Ángeles Márquez-Moñino, Ana Martínez Gascueña, Tala Azzam, Andrea Persson, Aitor Manzanares-Gomez, Marina Aguillo-Urarte, Trenton T. Brown, Ainhoa Montero-Sagarminaga, Rolf Lood, Andreas Naegeli, Sean R. Connell, Diego E. Sastre, Eric J. Sundberg, Beatriz Trastoy, "Molecular basis of Fab-dependent IgA antibody recognition by gut-bacterial metallopeptidases", The Embo Journal, 630 (2025), DOI: 10.1038/s44318-025-00518-w
- Vivien Yeh, Alice Goode, Nikul Khunti, Julie Watts, Christopher Parmenter, Michael Fay, David Johnson, Nathan Cowieson, Boyan Bonev, "Collapse of lipid membranes into distended lipidic cubic phases at high solvent levels, membrane remodelling, and self-repair", Journal Of The American Chemical Society (2025), DOI: 10.1021/jacs.5c07146
- Diego E. Sastre, Stylianos Bournazos, Maros Huliciak, Barbara Ann C. Grace, E. Josephine Boder, Jonathan Du, Nazneen Sultana, Tala Azzam, Trenton J. Brown, Maria W. Flowers, Pete Lollar, Ting Xu, Tatiana A. Chernova, Alasdair D. Keith, Meredith Keen, Abigail Saltzman, Ana Martinez Gascueña, Beatriz Trastoy, Marcelo Guerin, Filipp Frank, Eric A. Ortlund, Jeffrey V. Ravetch, Eric J. Sundberg, "The mechanistic basis for interprotomer deglycosylation of antibodies by corynebacterial IgG-specific endoglycosidases", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-60986-w
- Simona Bianco, Ravi R. Sonani, Dipankar Ghosh, Tejaswini Maurya, Thomas Bizien, Alice Pincham, Andrew J. Smith, Katsuaki Inoue, Annela Seddon, Massimo Vassalli, Edward H. Egelman, Dave J. Adams, "Modular salt-induced nanostructures formed by a functionalized dipeptide system", Matter, 142 (2025), DOI: 10.1016/j.matt.2025.102334
- Michael H. D'Souza, Higor Sette Pereira, Scott Tersteeg, Gunjan Vasudeva, M. Quadir Siddiqui, Temi Agunlejika, Liam Kerr, Dylan Girodat, Trushar Patel, "Solution structure determination and biophysical studies of 7SK RNP and 7SL SRP RNAs", Rna (2025), DOI: 10.1261/rna.080414.125
- [Thesis] Anisha Patel, "Enhancing sustainability in cross-linkable block copolymer formulations" (2025), DOI: 10.48780/publications.aston.ac.uk.00047845
- Lucas Battiston, Barbara Gerbelli, Fabiano Yokaichiya, Ivan Barros, Katia Oliveira, Cicero Avila-Neto, "Recycling spent synthesis liquor for enhanced production of ZIF-67: characterization and morphological insights", Chemnanomat, 57 (2025), DOI: 10.1002/cnma.202500100
- Ester Serrano, Tianxiao Zhao, David R. Mark, Mostafa Soroor, Iris Floria, Nicholas J. Terrill, Nikil Kapur, Arwen I. I. Tyler, Mathew H. Horrocks, Andrew J. Roe, Olwyn Byron, "Enterohaemorrhagic Escherichia coli AdhE spirosome length correlates with enzymatic directionality and is perturbed by salicylidene acylhydrazides", Open Biology, 15 (2025), DOI: 10.1098/rsob.250041
- Alessandro Cangiano, Noemi Gallucci, Antonella Giarra, Junaid Ali, Leonardo Chiappisi, Nathan P. Cowieson, Luigi Paduano, "Impact of solvent and ligand density on the self-assembly and optical properties of metal nanocrystals", Nanoscale, 16 (2025), DOI: 10.1039/D5NR01560J
- Guillem Hernandez, Maria l. Martins, Nuno p Fernandes, Tiago Veloso, João Lopes, Tiago Gomes, Tiago N. Cordeiro, "Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation", Nucleic Acids Research, 53 (2025), DOI: 10.1093/nar/gkaf502
- Robert P. Rambo, John A. Tainer, "Information theory optimization of signals from small angle scattering measurements", Biophysical Journal (2025), DOI: 10.1016/j.bpj.2025.06.031
- Jessica Rojas-Palomino, Carmen Velázquez, Jon Altuna-Alvarez, Amaia González-Magaña, Maialen Zabala-Zearreta, Matthias Müller, María Queralt-Martín, Antonio Alcaraz, David Albesa-Jove, "The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarization with K+ efflux", Plos Pathogens, 21 (2025), DOI: 10.1371/journal.ppat.1012981
- Priscila S. Ferreira, Barbara B. Gerbelli, Jorge Cantero, Federico Iribarne, Ana C. H. De Castro-Kochi, Leandro T. Kochi, Fabiola L. Castro, Wendel A. Alves, "Influence of cholesterol on the insertion and interaction of SARS-CoV-2 proteins with lipid membranes", Acs Applied Bio Materials, 924 (2025), DOI: 10.1021/acsabm.5c00776
- Subash Chapagain, Nicolas Salcedo-Porras, Amir Abdolahzadeh, Yaohua Zhang, Higor Sette Pereira, Stephane Flibotte, Kevin Low, Christina Young, Yuhang Wu, Shao Wang, Soh Ishiguro, Nozomu Yachie, Trushar Patel, Artem Babaian, Eric Jan, "Discovery of functional factorless internal ribosome entry site-like structures through virome mining", Plos Pathogens, 21 (2025), DOI: 10.1371/journal.ppat.1013255
- Alexander Leithner, Oskar Staufer, Tanmay Mitra, Falk Liberta, Salvatore Valvo, Mikhail Kutuzov, Hannah Dada, Jacob Spaeth, Weijie Zhou, Felix Schiele, Sophia Reindl, Herbert Nar, Stefan Hoerer, Maureen Crames, Stephen Comeau, David Young, Sarah Low, Edward Jenkins, Simon J. Davis, David Klenerman, Andrew Nixon, Noah Pefaur, David Wyatt, Omer Dushek, Srinath Kasturirangan, Michael L. Dustin, "Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency", Proceedings Of The National Academy Of Sciences, 122 (2025), DOI: 10.1073/pnas.2425781122
- Daniel Gussakovsky, Mira J. F. Brown, Higor Sette Pereira, Markus Meier, Gay P. Padilla-Meier, Nicole A. Black, Evan P. Booy, Jörg Stetefeld, Trushar R. Patel, Sean A. Mckenna, "Alu RNA pseudoknot alterations influence SRP9/SRP14 association", Rna (2025), DOI: 10.1261/rna.080359.124
- Mohammad Asadur Rahman, Subhadra Dalwani, Rajaram Venkatesan, "Structural enzymological studies of the long chain fatty acyl-CoA synthetase FadD5 from the mce1 operon of Mycobacterium tuberculosis", Biochemical And Biophysical Research Communications, 148 (2025), DOI: 10.1016/j.bbrc.2025.151960
- [Thesis] Freek Vincent De Graaf, "Controlling asymmetry in supramolecular polymer systems" (2025)
- Freek V. De Graaf, Christian Zoister, Boris Schade, Tarek Hilal, Xianwen Lou, Stefan Wijker, Sandra M. C. Schoenmakers, Ghislaine Vantomme, Rainer Haag, Abhishek K. Singh, Egbert W. Meijer, "Amplification of asymmetry via structural transitions in supramolecular polymer-surfactant coassemblies", Journal Of The American Chemical Society (2025), DOI: 10.1021/jacs.5c04047
- Cristian Andres Carmona-Carmona, Giovanni Bisello, Rossella Franchini, Gianluigi Lunardi, Roberta Galavotti, Massimiliano Perduca, Rui P. Ribeiro, Benny Danilo Belviso, Alejandro Giorgetti, Rocco Caliandro, Patricia M.-J. Lievens, Mariarita Bertoldi, "The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis", The Febs Journal, 139 (2025), DOI: 10.1111/febs.70120
- Ian W. Hamley, Lucas R. De Mello, Valeria Castelletto, Thomas Zinn, Nathan Cowieson, Jani Seitsonen, Thomas Bizien, "Semaglutide aggregates into oligomeric micelles and short fibrils in aqueous solution", Biomacromolecules (2025), DOI: 10.1021/acs.biomac.5c00342
- [Thesis] Karla De La Paz García, "Development and characterization of fluorescent nanosystems for the visualization of activated complement fragments" (2025)
- Anisha Patel, Georgia L. Maitland, Evelina Liarou, Paul D. Topham, Matthew J. Derry, "Transparent diblock copolymer nanoparticle dispersions via efficient RAFT emulsion polymerisation in ionic liquid", Polymer Chemistry, 117 (2025), DOI: 10.1039/D5PY00076A
- Jacob Pullin, Jorge Rodríguez-Celma, Marina Franceschetti, Julia E. A. Mundy, Dimitri A. Svistunenko, Justin M. Bradley, Nick Le Brun, Janneke Balk, "Iron-sensing and redox properties of the hemerythrin-like domains of Arabidopsis BRUTUS and BRUTUS-LIKE2 proteins", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-58853-9
- Sophie Winterbourne, Uma Jayachandran, Juan Zou, Juri Rappsilber, Sander Granneman, Atlanta G. Cook, "Integrative structural analysis of NF45–NF90 heterodimers reveals architectural rearrangements and oligomerization on binding dsRNA", Nucleic Acids Research, 53 (2025), DOI: 10.1093/nar/gkaf204
- Valeria Castelletto, Lucas R. De Mello, Juliane Pelin, Ian W. Hamley, "Self-assembly of toll-like receptor (TLR2/6) agonist lipidated amino acid or peptide conjugates: distinct morphologies and bioactivities", Bioconjugate Chemistry, 114 (2025), DOI: 10.1021/acs.bioconjchem.5c00051
- Jacek K. Wychowaniec, Ezgi Irem Bektas, Marcia Muerner, Jiranuwat Sapudom, Martin Šrejber, Marielle Airoldi, Roland Schmidt, Andrea J. Vernengo, Charlotte J. C. Edwards-Gayle, Paul Sean Tipay, Michal Otyepka, Jeremy Teo, David Eglin, Matteo D'Este, "Effect of tyrosine-containing self-assembling β-sheet peptides on macrophage polarization and inflammatory response", Acs Applied Materials & Interfaces (2025), DOI: 10.1021/acsami.4c19900
- Shaobai Wang, Theoni K. Georgiou, "Temperature- and time-dependent evolution of hydrogel network formed by thermoresponsive BCACB pentablock terpolymers: effect of composition", Polymer, 5 (2025), DOI: 10.1016/j.polymer.2025.128426
- Barbara B. Gerbelli, Pedro T. Sodré, Pedro L.o. Filho, Mauricio D. Coutinho-Neto, Ian W. Hamley, Jani Seitsonen, Wendel A. Alves, "Enhancing pesticide detection: The role of serine in lipopeptide nanostructures and their self-assembly dynamics", Journal Of Colloid And Interface Science, 43 (2025), DOI: 10.1016/j.jcis.2025.137271
- Luna Gade, Ben J. Boyd, Martin Malmsten, Andrea Heinz, "Phospholipase A2 induces structural changes in phospholipid-containing cubosomes", Colloids And Surfaces A: Physicochemical And Engineering Aspects, 25 (2025), DOI: 10.1016/j.colsurfa.2025.136604
- Matthew E. Allen, Yeyang Sun, Chi Long Chan, Miguel Paez-Perez, Oscar Ces, Yuval Elani, Claudia Contini, "Thermally driven dynamic behaviors in polymeric vesicles", Small (2025), DOI: 10.1002/smll.202411220
- C. J. Lalaurie, M. Zloh, D. R. Higazi, K. A. Bunting, P. A. Dalby, "Inter-domain interactions slow BoNT/A’s onset of action", Journal Of Structural Biology, 25 (2025), DOI: 10.1016/j.jsb.2025.108171
- Lucas r. De Mello, Valeria Castelletto, Leide Cavalcanti, Jani Seitsonen, Ian W. Hamley, "Self-assembly of a conjugate of lipoic acid with a collagen-stimulating pentapeptide showing cytocompatibility and wound healing properties, and chemical and photolytic disassembly", Journal Of Peptide Science, 31 (2025), DOI: 10.1002/psc.70002
- Saishree S. Iyer, Fangrui Chen, Funso E. Ogunmolu, Shoeib Moradi, Vladimir A. Volkov, Emma J. Van Grinsven, Chris Van Hoorn, Jingchao Wu, Nemo Andrea, Shasha Hua, Kai Jiang, Ioannis Vakonakis, Mia Potočnjak, Franz Herzog, Benoît Gigant, Nikita Gudimchuk, Kelly E. Stecker, Marileen Dogterom, Michel O. Steinmetz, Anna Akhmanova, "Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends", Journal Of Cell Biology, 224 (2025), DOI: 10.1083/jcb.202406061
- Hannah F. Bradford, Christophe J. Lalaurie, Jayesh Gor, Xin Gao, Charis Pericleous, Stephen J. Perkins, Hannah Britt, Konstantinos Thalassinos, Ian Giles, Anisur Rahman, Mihaela Delcea, Paul A. Dalby, Thomas C. R. Mcdonnell, "Plasmin cleavage of beta-2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies", Journal Of Thrombosis And Haemostasis (2025), DOI: 10.1016/j.jtha.2025.02.015
- Mélanie Loiodice, Elodie Drula, Zak Mciver, Svetlana Antonyuk, Arnaud Basle, Marcelo Lima, Edwin A. Yates, Dominic P. Byrne, Jamie Coughlan, Andrew Leech, Shahram Mesdaghi, Daniel J. Rigden, Sophie Drouillard, William Helbert, Bernard Henrissat, Nicolas Terrapon, Gareth S. A. Wright, Marie Couturier, Alan Cartmell, "Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel", Proceedings Of The National Academy Of Sciences, 122 (2025), DOI: 10.1073/pnas.2421623122
- [Thesis] Beatrice E. Jones, "Harnessing light-responsive structural control in surfactant assemblies" (2025), DOI: 10.17863/CAM.115838
- Mohamed A. N. Soliman, Abdulwahhab Khedr, Tarsem Sahota, Rachel Armitage, Raymond Allan, Katie Laird, Natalie Allcock, Fatmah I. Ghuloum, Mahetab H. Amer, Reem Alazragi, Charlotte J. C. Edwards-Gayle, Jacek K. Wychowaniec, Attilio V. Vargiu, Mohamed A. Elsawy, "Unraveling the atomistic mechanism of electrostatic lateral association of peptide β-sheet structures and its role in nanofiber growth and hydrogelation", Small (2025), DOI: 10.1002/smll.202408213
- Pijush Chakraborty, Markus Zweckstetter, "Interplay of p23 with FKBP51 and their chaperone complex in regulating tau aggregation", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-56028-0
- Mateusz P. Czub, Federico Uliana, Tarik Grubić, Celestino Padeste, Kathryn A. Rosowski, Charlotta Lorenz, Eric R. Dufresne, Andreas Menzel, Ioannis Vakonakis, Urs Gasser, Michel O. Steinmetz, "Phase separation of a microtubule plus-end tracking protein into a fluid fractal network", Nature Communications, 16 (2025), DOI: 10.1038/s41467-025-56468-8
- Anuradha De Silva, Kihun Kim, John Weiland, Jihyun Hwang, Jacky Chung, Higor S. Pereira, Trushar R. Patel, Joan Teyra, Ankoor Patel, Mohammed M. Mira, Mazdak Khajehpour, Melvin Bolton, Claudio Stasolla, Sachdev S. Sidhu, Brian L. Mark, "Suppressing Tymovirus replication in plants using a variant of ubiquitin", Plos Pathogens, 21 (2025), DOI: 10.1371/journal.ppat.1012899
- Anokhi Shah, Xiaoli Zhang, Matthew Snee, Michael P. Lockhart-Cairns, Colin W. Levy, Thomas A. Jowitt, Holly L. Birchenough, Louisa Dean, Richard Collins, Rebecca J. Dodd, Abigail R. E. Roberts, Jan J. Enghild, Alberto Mantovani, Juan Fontana, Clair Baldock, Antonio Inforzato, Ralf P. Richter, Anthony J. Day, "The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix", Matrix Biology, 57 (2025), DOI: 10.1016/j.matbio.2025.01.002
- [Thesis] Georgia L. Maitland, "A novel route to ionogels using polymerisation-induced self-assembly in ionic liquid" (2025), DOI: 10.48780/publications.aston.ac.uk.00047182
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