Regulation of human HSC70 ATPase and chaperone activities by Apg2: Role of the acidic subdomain Yovana Cabrera, Leire Dublang, José Angel Fernández-Higuero, David Albesa-Jove, Maria Lucas, Ana Rosa Viguera, Marcelo E. Guerin, Jose M. G. Vilar, Arturo Muga, Fernando Moro
Journal Of Molecular Biology, Dec 2018 DOI: 10.1016/j.jmb.2018.11.026 Ferredoxin-linked flavoenzyme defines a family of pyridine nucleotide-independent thioredoxin reductases Ruben M. Buey, David Fernandez-Justel, Jose M. De Pereda, José L. Revuelta, Peter Schürmann, Bob B. Buchanan, Monica Balsera
Proceedings Of The National Academy Of Sciences, 239 Dec 2018 DOI: 10.1073/pnas.1812781115 Journal Paper B21-High Throughput SAXS I24-Microfocus Macromolecular Crystallography Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1 James M. Dunce, Amy E. Milburn, Manickam Gurusaran, Irene Da Cruz, Lee T. Sen, Ricardo Benavente, Owen R. Davies
Nature Communications, 9 Dec 2018 DOI: 10.1038/s41467-018-07794-7 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity Neha Nirwan, Pratima Singh, Gyana Gourab Mishra, Christopher M. Johnson, Mark D. Szczelkun, Katsuaki Inoue, Kutti R. Vinothkumar, Kayarat Saikrishnan
Nucleic Acids Research, 57 Dec 2018 DOI: 10.1093/nar/gky1170 Interactome rewiring following pharmacological targeting of BET bromodomains Jean-Philippe Lambert, Sarah Picaud, Takao Fujisawa, Huayun Hou, Pavel Savitsky, Liis Uusküla-Reimand, Gagan D. Gupta, Hala Abdouni, Zhen-Yuan Lin, Monika Tucholska, James D. R. Knight, Beatriz Gonzalez-Badillo, Nicole St-Denis, Joseph A. Newman, Manuel Stucki, Laurence Pelletier, Nuno Bandeira, Michael D. Wilson, Panagis Filippakopoulos, Anne-Claude Gingras
Molecular Cell, Dec 2018 DOI: 10.1016/j.molcel.2018.11.006 Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access Biochemical characterization and low-resolution SAXS structure of two-domain endoglucanase BlCel9 from Bacillus licheniformis Evandro Ares De Araújo, Mário De Oliveira Neto, Igor Polikarpov
Applied Microbiology And Biotechnology, 111 Dec 2018 DOI: 10.1007/s00253-018-9508-1 Measurement of forces between supported cationic bilayers by colloid probe atomic force microscopy: electrolyte concentration and composition Matthew Leivers, John M. Seddon, Marc Declercq, Eric S. J. Robles, Paul Frederick Luckham
Langmuir, Dec 2018 DOI: 10.1021/acs.langmuir.8b03555 Interaction of the gtpase elongation factor Like-1 with the Shwachman-Diamond Syndrome protein and its missense mutations Abril Gijsbers, Diana Montagut, Alfonso Méndez-Godoy, Davide Altamura, Michele Saviano, Dritan Siliqi, Nuria Sánchez-Puig
International Journal Of Molecular Sciences, 19 Dec 2018 DOI: 10.3390/ijms19124012 Amino-acid-based metallo-hydrogel that acts like an esterase Kousik Gayen, Kingshuk Basu, Dipayan Bairagi, Valeria Castelletto, Ian W. Hamley, Arindam Banerjee
Acs Applied Bio Materials, Nov 2018 DOI: 10.1021/acsabm.8b00513 A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity Marta Compte, Seandean Lykke Harwood, Ines G. Munoz, Rocio Navarro, Manuela Zonca, Gema Perez-Chacon, Ainhoa Erce-Llamazares, Nekane Merino, Antonio Tapia-Galisteo, Angel M. Cuesta, Kasper Mikkelsen, Eduardo Caleiras, Natalia Nuñez-Prado, M. Angela Aznar, Simon Lykkemark, Jorge Martínez-Torrecuadrada, Ignacio Melero, Francisco J. Blanco, Jorge Bernardino De La Serna, Juan M. Zapata, Laura Sanz, Luis Alvarez-Vallina
Nature Communications, 9 Nov 2018 DOI: 10.1038/s41467-018-07195-w Structural variability of EspG chaperones from mycobacterial ESX-1, ESX-3 and ESX-5 Type VII secretion systems Anne T. Tuukkanen, Diana Freire, Sum Chan, Mark A. Arbing, Robert W. Reed, Timothy J. Evans, Grasilda Zenkeviciutė, Jennifer Kim, Sara Kahng, Michael R. Sawaya, Catherine T. Chaton, Matthias Wilmanns, David Eisenberg, Annabel H. A. Parret, Konstantin V. Korotkov
Journal Of Molecular Biology, Nov 2018 DOI: 10.1016/j.jmb.2018.11.003 Crystal structure of the apo-form of NADPH-dependent thioredoxin reductase from a methane-producing archaeon Ruben M. Buey, Ruth A. Schmitz, Bob B. Buchanan, Monica Balsera
Antioxidants, 7 Nov 2018 DOI: 10.3390/antiox7110166 Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities Erik I. Hallin, Maria S. Eriksen, Sergei Baryshnikov, Oleksii Nikolaienko, Sverre Grødem, Tomohisa Hosokawa, Yasunori Hayashi, Clive R. Bramham, Petri Kursula
Journal Of Neurochemistry, 147 Nov 2018 DOI: 10.1111/jnc.14556 The molecular basis of protein toxin HicA–dependent binding of the protein antitoxin HicB to DNA Ashley J. Winter, Christopher Williams, Michail N. Isupov, Hannah Crocker, Mariya Gromova, Philip Marsh, Oliver J. Wilkinson, Mark S. Dillingham, Nicholas J. Harmer, Richard W. Titball, Matthew P. Crump
Journal Of Biological Chemistry, Oct 2018 DOI: 10.1074/jbc.RA118.005173 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens Vivek Srinivas, Hugo Lebrette, Daniel Lundin, Yuri Kutin, Margareta Sahlin, Michael Lerche, Jürgen Eirich, Rui M. M. Branca, Nicholas Cox, Britt-Marie Sjöberg, Martin Högbom
Nature, 47 Oct 2018 DOI: 10.1038/s41586-018-0653-6 Journal Paper B21-High Throughput SAXS I24-Microfocus Macromolecular Crystallography The X-ray structure of human calbindin-D28K: an improved model James W. Noble, Rehab Almalki, S. Mark Roe, Armin Wagner, Ramona Duman, John Atack
Acta Crystallographica Section D Structural Biology, 74 Oct 2018 DOI: 10.1107/S2059798318011610 Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I23-Long wavelength MX open access It takes a dimer to tango: Oligomeric small heat shock proteins dissociate to capture substrate Indu Santhanagopalan, Matteo T. Degiacomi, Dale A. Shepherd, Georg K. A. Hochberg, Justin L. P. Benesch, Elizabeth Vierling
Journal Of Biological Chemistry, Oct 2018 DOI: 10.1074/jbc.RA118.005421 Conformation and aggregation of selectively pegylated and lipidated gastric peptide hormone human PYY 3-36 Valeria Castelletto, Ian W. Hamley, Jani Seitsonen, Janne Ruokolainen, Gemma Harris, Kathrin Bellmann-Sickert, Annette G. Beck-Sickinger
Biomacromolecules, Sept 2018 DOI: 10.1021/acs.biomac.8b01209 High-affinity heterotetramer formation between the large myelin-associated glycoprotein and the dynein light chain DYNLL1 Matti Myllykoski, Maria A. Eichel, Ramona B. Jung, Sørge Kelm, Hauke B. Werner, Petri Kursula
Journal Of Neurochemistry, Sept 2018 DOI: 10.1111/jnc.14598 X-ray structure of full-length human RuvB-Like 2 – mechanistic insights into coupling between ATP binding and mechanical action Sara Silva, Jose A. Brito, Rocío Arranz, Carlos Óscar S. Sorzano, Christine Ebel, James Doutch, Mark D. Tully, José-María Carazo, José L. Carrascosa, Pedro M. Matias, Tiago M. Bandeiras
Scientific Reports, 8 Sept 2018 DOI: 10.1038/s41598-018-31997-z Biocompatible single-chain polymer nanoparticles for drug delivery – a dual approach A. Pia P. Kroger, Naomi M. Hamelmann, Alberto Juan, Saskia Lindhoud, Jos M. J. Paulusse
Acs Applied Materials & Interfaces, Aug 2018 DOI: 10.1021/acsami.8b07450 Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER Michael P. Lockhart-Cairns, Karen Tzia Wei Lim, Alexandra Zuk, Alan R. F. Godwin, Stuart A. Cain, Gerhard Sengle, Clair Baldock
Matrix Biology, Aug 2018 DOI: 10.1016/j.matbio.2018.08.006 Bacillus subtilis HelD, an RNA polymerase interacting helicase, forms amyloid-like fibrils Gundeep Kaur, Srajan Kapoor, Krishan G. Thakur
Frontiers In Microbiology, 9 Aug 2018 DOI: 10.3389/fmicb.2018.01934 Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease Ekaterina Biterova, Alexander Ignatyev, Johanna Uusimaa, Reetta Hinttala, Lloyd W. Ruddock
Plos One, 13 Aug 2018 DOI: 10.1371/journal.pone.0202391 Pectin conformation in solution Katerina Alba, Richard J. Bingham, Patrick A. Gunning, Peter J. Wilde, V. Kontogiorgos
The Journal Of Physical Chemistry B, Jul 2018 DOI: 10.1021/acs.jpcb.8b04790 Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils Gundeep Kaur, Soni Kaundal, Srajan Kapoor, Jonathan M. Grimes, Juha T. Huiskonen, Krishan Gopal Thakur
Scientific Reports, 8 Jul 2018 DOI: 10.1038/s41598-018-28290-4 Merging in-solution x-ray and neutron scattering data allows fine structural analysis of membrane–protein detergent complexes Gaetan Dias Mirandela, Giulia Tamburrino, Miloš T. Ivanović, Felix M. Strnad, Olwyn Byron, Tim Rasmussen, Paul A. Hoskisson, Jochen S. Hub, Ulrich Zachariae, Frank Gabel, Arnaud Javelle
The Journal Of Physical Chemistry Letters, Jul 2018 DOI: 10.1021/acs.jpclett.8b01598 Restructuring of lipid membranes by an arginine-capped peptide bolaamphiphile Valeria Castelletto, Ruth H. Barnes, Kimon-Andreas Karatzas, Charlotte J. C. Edwards-Gayle, Francesca Greco, Ian W. Hamley, Jani Seitsonen, Janne Ruokolainen
Langmuir, Jul 2018 DOI: 10.1021/acs.langmuir.8b01014 Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly James M. Dunce, Orla M. Dunne, Matthew Ratcliff, Claudia Millán, Suzanne Madgwick, Isabel Uson, Owen R. Davies
Nature Structural & Molecular Biology, 7 June 2018 DOI: 10.1038/s41594-018-0078-9 Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access The structure of SALM5 suggests a dimeric assembly for the presynaptic RPTP ligand recognition Sudeep Karki, Prodeep Paudel, Celeste Sele, Alexander V. Shkumatov, Tommi Kajander
Protein Engineering, Design And Selection, 44 June 2018 DOI: 10.1093/protein/gzy012 Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition D. Sean Froese, Jolanta Kopec, Elzbieta Rembeza, Gustavo Arruda Bezerra, Anselm Erich Oberholzer, Terttu Suormala, Seraina Lutz, Rod Chalk, Oktawia Borkowska, Matthias R. Baumgartner, Wyatt W. Yue
Nature Communications, 9 June 2018 DOI: 10.1038/s41467-018-04735-2 Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) open access The effect of lipidation on the self-assembly of the gut derived peptide hormone PYY3-36 Jessica A. Hutchinson, Samuel Burholt, Ian W. Hamley, Anna-Karin Lundback, Shahid Uddin, Ana Lucia Gomes Dos Santos, Mehedi Reza, Jani Seitsonen, Janne Ruokolainen
Bioconjugate Chemistry, June 2018 DOI: 10.1021/acs.bioconjchem.8b00286 Journal Paper B21-High Throughput SAXS I22-Small angle scattering & Diffraction Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge Markus Meier, Aniel Moya-Torres, Natalie J. Krahn, Matthew D. Mcdougall, George L. Orriss, Ewan K. S. Mcrae, Evan P. Booy, Kevin Mceleney, Trushar R. Patel, Sean A. Mckenna, Jörg Stetefeld
Nucleic Acids Research, 34 May 2018 DOI: 10.1093/nar/gky307 Arginine-containing surfactant-like peptides: Interaction with lipid membranes and antimicrobial activity Valeria Castelletto, Ruth H. Barnes, Kimon-Andreas Karatzas, Charlotte J. C. Edwards-Gayle, Francesca Greco, Ian W. Hamley, Robert Rambo, Jani Seitsonen, Janne Ruokolainen
Biomacromolecules, May 2018 DOI: 10.1021/acs.biomac.8b00391 Journal Paper B21-High Throughput SAXS I22-Small angle scattering & Diffraction Stability of local secondary structure determines selectivity of viral RNA chaperones Jack P. K. Bravo, Alexander Borodavka, Anders Barth, Antonio N. Calabrese, Peter Mojzes, Joseph J. B. Cockburn, Don C. Lamb, Roman Tuma
Nucleic Acids Research, 190 May 2018 DOI: 10.1093/nar/gky394 Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S Beatriz Trastoy, Erik Klontz, Jared Orwenyo, Alberto Marina, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin
Nature Communications, 9 May 2018 DOI: 10.1038/s41467-018-04300-x An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles Stephen C. L. Hall, Cecilia Tognoloni, Jack Charlton, Eilis C. Bragginton, Alice J. Rothnie, Pooja Sridhar, Mark Wheatley, Timothy J. Knowles, Thomas Arnold, Karen J. Edler, Tim R. Dafforn
Nanoscale, May 2018 DOI: 10.1039/C8NR01322E Structural and functional characterisation of feline calicivirus entry Michaela Jayne Conley
Apr 2018 Thesis B21-High Throughput SAXS
Structure of Radical-Induced Cell Death1 hub domain reveals a common αα-scaffold for disorder in transcriptional networks Katrine Bugge, Lasse Staby, Katherine R. Kemplen, Charlotte O'Shea, Sidsel K. Bendsen, Mikael K. Jensen, Johan G. Olsen, Karen Skriver, Birthe B. Kragelund
Structure, Apr 2018 DOI: 10.1016/j.str.2018.03.013 Oligonucleotide length dependent formation of virus-like particles Stan J. Maassen, Mark Vincent De Ruiter, Saskia Lindhoud, Jeroen J. L. M. Cornelissen
Chemistry - A European Journal, Mar 2018 DOI: 10.1002/chem.201800285 Structural and functional studies on CHFR autoubiquitination Leanna Louise Smith
Mar 2018 Thesis B21-High Throughput SAXS
The conformation and aggregation of proline-rich surfactant-like peptides Ian W. Hamley, Valeria Castelletto, Ashkan Dehsorkhi, Juan Torras, Carlos Aleman, Irina Portnaya, Dganit Danino
The Journal Of Physical Chemistry B, Feb 2018 DOI: 10.1021/acs.jpcb.7b11463 Conformational flexibility of proteins involved in ribosome biogenesis: investigations via Small Angle X-Ray Scattering (SAXS) Dritan Siliqi, James Foadi, Marco Mazzorana, Davide Altamura, Alfonso Méndez-Godoy, Nuria Sánchez-Puig
Crystals, 8 Feb 2018 DOI: 10.3390/cryst8030109 Journal Paper B21-High Throughput SAXS I24-Microfocus Macromolecular Crystallography open access Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions Georg K. A. Hochberg, Dale A. Shepherd, Erik G. Marklund, Indu Santhanagoplan, Matteo T. Degiacomi, Arthur Laganowsky, Timothy M. Allison, Eman Basha, Michael T. Marty, Martin R. Galpin, Weston B. Struwe, Andrew J. Baldwin, Elizabeth Vierling, Justin L. P. Benesch
Science, 359 Feb 2018 DOI: 10.1126/science.aam7229 Journal Paper B21-High Throughput SAXS I04-Macromolecular Crystallography A novel approach to increase the stability of liposomal containers via in prep coating by poly[n-(2-hydroxypropyl)methacrylamide] with covalently attached cholesterol groups Olga V. Zaborova, Sergey K. Filippov, Petr Chytil, Lubomir Kováčik, Karel Ulbrich, Alexander A. Yaroslavov, Tomaš Etrych
Macromolecular Chemistry And Physics, 4 Jan 2018 DOI: 10.1002/macp.201700508 Investigation into the mechanism of homo- and heterodimerization of angiotensin-converting enzyme J. Albert Abrie, Wessel J. A. Moolman, Gyles E. Cozier, Sylva L. Schwager, K. Ravi Acharya, Edward D. Sturrock
Molecular Pharmacology, Jan 2018 DOI: 10.1124/mol.117.110866 Structural characterization of nanoparticles formed by fluorinated poly(2-oxazoline)-based polyphiles Anna Riabtseva, Leonid I. Kaberov, Laurence Noirez, Vasyl Ryukhtin, Corinne Nardin, Bart Veerbraeken, Richard Hoogenboom, Petr Stepanek, Sergey K. Filippov
European Polymer Journal, Jan 2018 DOI: 10.1016/j.eurpolymj.2018.01.007