Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy B21 Contact
Beamline phone numbers:
+44 (0) 1235 77 8627
+44 (0) 1235 77 8640
Principal Beamline Scientist:
Nathan Cowieson
Tel: +44 (0) 1235 567 504
E-mail: [email protected]
Science Group Leader
Robert Rambo
Email: [email protected]
Tel: +44 (0)1235 56 7675
B21 High Throughput SAXS
Status: Operational
Beamsize: <75 μm
Detector: Eiger 4M
Energy: 6 - 23 keV
Detector: Eiger 4M
Energy: 6 - 23 keV
36 items found for 2017 [total: 654]
Multiple conformational states contribute to the 3D structure of a glucan decasaccharide: a combined SAXS and MD simulation study The Journal Of Physical Chemistry B, Dec 2017 DOI: 10.1021/acs.jpcb.7b11085
Journal Paper B21-High Throughput SAXS
Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL Proceedings Of The National Academy Of Sciences, 27 Dec 2017 DOI: 10.1073/pnas.1715361115
High affinity binding of Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1) to Lu/BCAM adhesion glycoprotein Toxins, 10 Dec 2017 DOI: 10.3390/toxins10010003
Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities Polymer Chemistry, Dec 2017 DOI: 10.1039/C7PY01953J
Mechanistic insights into autoinhibition of the oncogenic chromatin remodeler ALC1 Molecular Cell, 68 Dec 2017 DOI: 10.1016/j.molcel.2017.10.017
Self-assembly of telechelic tyrosine end-capped PEO star polymers in aqueous solution Biomacromolecules, Dec 2017 DOI: 10.1021/acs.biomac.7b01420
Journal Paper B21-High Throughput SAXS
Complex three-dimensional self-assembly in proxies for atmospheric aerosols Nature Communications, 8 Nov 2017 DOI: 10.1038/s41467-017-01918-1
Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties Journal Of Biological Chemistry, Nov 2017 DOI: 10.1074/jbc.M117.815258
Cooking oil and clouds Nov 2017
Science Highlight B21-High Throughput SAXS
Biochemical characterization and low-resolution SAXS structure of an exo-polygalacturonase from Bacillus licheniformis New Biotechnology, Oct 2017 DOI: 10.1016/j.nbt.2017.10.001
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases Biochemical Journal, Sept 2017 DOI: 10.1042/BCJ20170527
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Two wrongs to make it right Sept 2017
Science Highlight B21-High Throughput SAXS
A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R Febs Letters, Aug 2017 DOI: 10.1002/1873-3468.12772
Journal Paper B21-High Throughput SAXS
Water-based fractionation of a commercial humic acid. Solid-state and colloidal characterization of the solubility fractions Journal Of Colloid And Interface Science, Aug 2017 DOI: 10.1016/j.jcis.2017.08.031
Journal Paper B21-High Throughput SAXS
Supramolecular peptide nanofiber morphology affects mechanotransduction of stem cells Biomacromolecules, Aug 2017 DOI: 10.1021/acs.biomac.7b00773
Journal Paper B21-High Throughput SAXS
Self-sorted oligophenylvinylene and perylene bisimide hydrogels Scientific Reports, 7 Aug 2017 DOI: 10.1038/s41598-017-08644-0
Coarse-grained modeling of antibodies from small-angle scattering profiles The Journal Of Physical Chemistry B, 121 Aug 2017 DOI: 10.1021/acs.jpcb.7b04621
Journal Paper B21-High Throughput SAXS
Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis Nature Chemical Biology, 1146 Jul 2017 DOI: 10.1038/nchembio.2434
GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression Genes & Development, 31 Jul 2017 DOI: 10.1101/gad.299420.117
Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites Journal Of Biological Chemistry, June 2017 DOI: 10.1074/jbc.M117.792374
The structure of the tetanus toxin reveals pH‐mediated domain dynamics Embo Reports, June 2017 DOI: 10.15252/embr.201744198
Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) Krios I-Titan Krios I at Diamond
The herpes viral transcription factor ICP4 forms a novel DNA recognition complex Nucleic Acids Research, May 2017 DOI: 10.1093/nar/gkx419
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I04-Macromolecular Crystallography open access
The architecture of the AnBu complex reflects an evolutionary intermediate at the origin of the proteasome system Structure, May 2017 DOI: 10.1016/j.str.2017.04.005
The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA Nature Communications, 8 Apr 2017 DOI: 10.1038/ncomms14861
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Twitchin kinase inhibits muscle activity Molecular Biology Of The Cell, Apr 2017 DOI: 10.1091/mbc.E16-10-0707
Journal Paper B21-High Throughput SAXS
The tetrameric plant lectin BanLec neutralizes HIV through bidentate binding to specific viral glycans Structure, Apr 2017 DOI: 10.1016/j.str.2017.03.015
Synthetic toxic Aß 1–42 oligomers can assemble in different morphologies Biochimica Et Biophysica Acta (bba) - General Subjects, Mar 2017 DOI: 10.1016/j.bbagen.2017.03.001
Journal Paper B21-High Throughput SAXS
Structural basis of homo- and heterotrimerization of collagen I Nature Communications, 8 Mar 2017 DOI: 10.1038/ncomms14671
Using Small Angle X-Ray Scattering (SAXS) to characterize the solution conformation and flexibility of Matrix Metalloproteinases (MMPs) Mar 2017 DOI: 10.1007/978-1-4939-6863-3_6
Book Chapter B21-High Throughput SAXS
Assessing the potential of folded globular polyproteins as hydrogel building blocks Biomacromolecules, Jan 2017 DOI: 10.1021/acs.biomac.6b01877
Specialized interfaces of Smc5/6 control hinge stability and DNA association Nature Communications, 8 Jan 2017 DOI: 10.1038/ncomms14011
Polyelectrolyte pH-responsive protein-containing nanoparticles: the physico-chemical supramolecular approach Langmuir, Jan 2017 DOI: 10.1021/acs.langmuir.6b03778
Journal Paper B21-High Throughput SAXS
Hybrid membrane biomaterials from self-assembly in polysaccharide and peptide amphiphile mixtures: controllable structural and mechanical properties and antimicrobial activity Rsc Advances, 7 Jan 2017 DOI: 10.1039/C6RA27244D
New insights into the GINS complex explain the controversy between existing structural models Scientific Reports, 7 Jan 2017 DOI: 10.1038/srep40188
Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments Scientific Reports, 7 Jan 2017 DOI: 10.1038/srep40405
Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5 Nucleic Acids Research, Jan 2017 DOI: 10.1093/nar/gkw1362
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
- Sunhwan Jo, Daniel Myatt, Yifei Qi, James Doutch, Luke A. Clifton, Wonpil Im, Göran Widmalm, "Multiple conformational states contribute to the 3D structure of a glucan decasaccharide: a combined SAXS and MD simulation study", The Journal Of Physical Chemistry B (2017), DOI: 10.1021/acs.jpcb.7b11085
- Miguel Romano-Moreno, Adriana L. Rojas, Chad D. Williamson, David C. Gershlick, María Lucas, Michail N. Isupov, Juan S. Bonifacino, Matthias P. Machner, Aitor Hierro, "Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL", Proceedings Of The National Academy Of Sciences, 27 (2017), DOI: 10.1073/pnas.1715361115
- Franziska Reppin, Sylvie Cochet, Wassim El Nemer, Guenter Fritz, Gudula Schmidt, "High affinity binding of Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1) to Lu/BCAM adhesion glycoprotein", Toxins, 10 (2017), DOI: 10.3390/toxins10010003
- Manuel Hartweg, Charlotte J. C. Edwards-Gayle, Elham Radvar, Dominic W. P. Collis, Mehedi Reza, Michael Kaupp, Jan Steinkönig, Janne Ruokolainen, Robert Rambo, Christopher Barner-Kowollik, Ian W. Hamley, Helena S. Azevedo, C. Remzi Becer, "Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities", Polymer Chemistry (2017), DOI: 10.1039/C7PY01953J
- Laura C. Lehmann, Graeme Hewitt, Shintaro Aibara, Alexander Leitner, Emil Marklund, Sarah L. Maslen, Varun Maturi, Yang Chen, David Van Der Spoel, J. Mark Skehel, Aristidis Moustakas, Simon J. Boulton, Sebastian Deindl, "Mechanistic insights into autoinhibition of the oncogenic chromatin remodeler ALC1", Molecular Cell, 68, 847 - 859.e7 (2017), DOI: 10.1016/j.molcel.2017.10.017
- Charlotte J. C. Edwards-Gayle, Francesca Greco, Ian W. Hamley, Robert P. Rambo, Mehedi Reza, Janne Ruokolainen, Dimitrios Skoulas, Hermis Iatrou, "Self-assembly of telechelic tyrosine end-capped PEO star polymers in aqueous solution", Biomacromolecules (2017), DOI: 10.1021/acs.biomac.7b01420
- C. Pfrang, K. Rastogi, Edna Cabrera-Martinez, A. M. Seddon, C. Dicko, A. Labrador, T. S. Plivelic, N. Cowieson, A. M. Squires, "Complex three-dimensional self-assembly in proxies for atmospheric aerosols", Nature Communications, 8 (2017), DOI: 10.1038/s41467-017-01918-1
- Adrian C. D. Fuchs, Lorena Maldoner, Katharina Hipp, Marcus D. Hartmann, Jörg Martin, "Structural characterization of the bacterial proteasome homolog BPH reveals a tetradecameric double-ring complex with unique inner cavity properties", Journal Of Biological Chemistry (2017), DOI: 10.1074/jbc.M117.815258
- [Science Highlight] Diamond Light Source, "Cooking oil and clouds" (2017)
- Danilo Elton Evangelista, Evandro A. De Araujo, Mario Oliveira Neto, Seiki Kadowaki, Igor Polikarpov, "Biochemical characterization and low-resolution SAXS structure of an exo-polygalacturonase from Bacillus licheniformis", New Biotechnology (2017), DOI: 10.1016/j.nbt.2017.10.001
- Daniel M. Pinkas, Caroline E. Sanvitale, Joshua C. Bufton, Fiona J. Sorrell, Nicolae Solcan, Rod Chalk, James Doutch, Alex N. Bullock, "Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases", Biochemical Journal (2017), DOI: 10.1042/BCJ20170527
- [Science Highlight] Diamond Light Source, "Two wrongs to make it right" (2017)
- Ines G. Munoz, Bertrand Morel, Encarnación Medina-Carmona, Angel L. Pey, "A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R", Febs Letters (2017), DOI: 10.1002/1873-3468.12772
- Weronika M. Swiech, Ian Hamerton, Huang Zeng, David J. Watson, Eleonore Mason, Spencer E. Taylor, "Water-based fractionation of a commercial humic acid. Solid-state and colloidal characterization of the solubility fractions", Journal Of Colloid And Interface Science (2017), DOI: 10.1016/j.jcis.2017.08.031
- Elif Arslan, Meryem Hatip Koc, Ozge Uysal, Begum Dikecoglu, Ahmet Emin Topal, Ruslan Garifullin, Alper D. Ozkan, Aykutlu Dana, Daniel Hermida-Merino, Valeria Castelletto, Charlotte Edwards-Gayle, Sefer Baday, Ian W. Hamley, Ayse Begum Tekinay, Mustafa O. Guler, "Supramolecular peptide nanofiber morphology affects mechanotransduction of stem cells", Biomacromolecules (2017), DOI: 10.1021/acs.biomac.7b00773
- Ana M. Castilla, Emily R. Draper, Michael C. Nolan, Christopher Brasnett, Annela Seddon, Laura L. E. Mears, Nathan Cowieson, Dave Adams, "Self-sorted oligophenylvinylene and perylene bisimide hydrogels", Scientific Reports, 7 (2017), DOI: 10.1038/s41598-017-08644-0
- Daniel Corbett, Max Hebditch, Rose Keeling, Peng Ke, Sofia Ekizoglou, Prasad Sarangapani, Jai Pathak, Christopher F. Van Der Walle, Shahid Uddin, Clair Baldock, Carlos Avendaño, Robin A. Curtis, "Coarse-grained modeling of antibodies from small-angle scattering profiles", The Journal Of Physical Chemistry B, 121, 8276 - 8290 (2017), DOI: 10.1021/acs.jpcb.7b04621
- Deepanker Gahloth, Mark S. Dunstan, Daniela Quaglia, Evaldas Klumbys, Michael P. Lockhart-Cairns, Andrew M. Hill, Sasha R. Derrington, Nigel S. Scrutton, Nicholas J Turner, David Leys, "Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis", Nature Chemical Biology, 1146 (2017), DOI: 10.1038/nchembio.2434
- Daniel Peter, Ramona Weber, Felix Sandmeir, Lara Wohlbold, Sigrun Helms, Praveen Bawankar, Eugene Valkov, Cátia Igreja, Elisa Izaurralde, "GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression", Genes & Development, 31, 1147 - 1161 (2017), DOI: 10.1101/gad.299420.117
- John G. Mina, Julie K. Thye, Amjed Q. I. Alqaisi, Louise Bird, Robert H. Dods, Morten Groftehauge, Jackie A. Mosely, Steven Pratt, Hosam Shams-Eldin, Ralph T. Schwarz, Ehmke Pohl, Paul W. Denny, "Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites", Journal Of Biological Chemistry (2017), DOI: 10.1074/jbc.M117.792374
- Geoffrey Masuyer, Julian Conrad, Pal Stenmark, "The structure of the tetanus toxin reveals pH‐mediated domain dynamics", Embo Reports (2017), DOI: 10.15252/embr.201744198
- Richard B. Tunnicliffe, Michael P. Lockhart-Cairns, Colin Levy, A. Paul Mould, Thomas A. Jowitt, Hilary Sito, Clair Baldock, Rozanne M. Sandri-Goldin, Alexander P. Golovanov, "The herpes viral transcription factor ICP4 forms a novel DNA recognition complex", Nucleic Acids Research (2017), DOI: 10.1093/nar/gkx419
- Adrian C. D. Fuchs, Vikram Alva, Lorena Maldoner, Reinhard Albrecht, Marcus D. Hartmann, Jörg Martin, "The architecture of the AnBu complex reflects an evolutionary intermediate at the origin of the proteasome system", Structure (2017), DOI: 10.1016/j.str.2017.04.005
- Sina Wittmann, Max Renner, Beth R. Watts, Oliver Adams, Miles Huseyin, Carlo Baejen, Kamel El Omari, Cornelia Kilchert, Dong-Hyuk Heo, Tea Kecman, Patrick Cramer, Jonathan Grimes, Lidia Vasiljeva, "The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA", Nature Communications, 8 (2017), DOI: 10.1038/ncomms14861
- Yohei Matsunaga, Hyundoo Hwang, Barbara Franke, Rhys Williams, Mckenna Penley, Hiroshi Qadota, Hong Yi, Levi T. Morran, Hang Lu, Olga Mayans, Guy M. Benian, "Twitchin kinase inhibits muscle activity", Molecular Biology Of The Cell (2017), DOI: 10.1091/mbc.E16-10-0707
- Jonathan T. S. Hopper, Stephen Ambrose, Oliver C. Grant, Stefanie A. Krumm, Timothy Allison, Matteo T. Degiacomi, Mark D. Tully, Laura K. Pritchard, Gabriel Ozorowski, Andrew B. Ward, Max Crispin, Katie J. Doores, Robert J. Woods, Justin L. P. Benesch, Carol V. Robinson, Weston B. Struwe, "The tetrameric plant lectin BanLec neutralizes HIV through bidentate binding to specific viral glycans", Structure (2017), DOI: 10.1016/j.str.2017.03.015
- Claude Bobo, Stéphane Chaignepain, Sarah Henry, Hélène Vignaud, Alfred Améadan, Christelle Marchal, Enora Prado, James Doutch, Jean-Marie Schmitter, Corinne Nardin, Sophie Lecomte, Christophe Cullin, "Synthetic toxic Aß 1–42 oligomers can assemble in different morphologies", Biochimica Et Biophysica Acta (bba) - General Subjects (2017), DOI: 10.1016/j.bbagen.2017.03.001
- Urvashi Sharma, Loïc Carrique, Sandrine Vadon-Le Goff, Natacha Mariano, Rainier-Numa Georges, Frederic Delolme, Peppi Koivunen, Johanna Myllyharju, Catherine Moali, Nushin Aghajari, David J. S. Hulmes, "Structural basis of homo- and heterotrimerization of collagen I", Nature Communications, 8 (2017), DOI: 10.1038/ncomms14671
- [Book Chapter] Louise E. Butt, Robert A. Holland, Nikul S. Khunti, Debra L. Quinn, Andrew R. Pickford, "Using Small Angle X-Ray Scattering (SAXS) to characterize the solution conformation and flexibility of Matrix Metalloproteinases (MMPs)" (2017), DOI: 10.1007/978-1-4939-6863-3_6
- Marcelo A. Da Silva, Samuel Lenton, Matthew Hughes, David J. Brockwell, Lorna Dougan, "Assessing the potential of folded globular polyproteins as hydrogel building blocks", Biomacromolecules (2017), DOI: 10.1021/acs.biomac.6b01877
- Aaron Alt, Hung Q. Dang, Owen S. Wells, Luis M. Polo, Matt A. Smith, Grant A. Mcgregor, Thomas Welte, Alan R. Lehmann, Laurence H. Pearl, Johanne M. Murray, Antony W. Oliver, "Specialized interfaces of Smc5/6 control hinge stability and DNA association", Nature Communications, 8 (2017), DOI: 10.1038/ncomms14011
- Anna Riabtseva, Leonid I. Kaberov, Jan Kucka, Anna Yurevna Bogomolova, Petr Stepanek, Sergey Filippov, Martin Hruby, "Polyelectrolyte pH-responsive protein-containing nanoparticles: the physico-chemical supramolecular approach", Langmuir (2017), DOI: 10.1021/acs.langmuir.6b03778
- V. Castelletto, A. Kaur, I. W. Hamley, R. H. Barnes, K.-A. Karatzas, D. Hermida-Merino, S. Swioklo, C. J. Connon, Joanna Stasiak, M. Reza, J. Ruokolainen, "Hybrid membrane biomaterials from self-assembly in polysaccharide and peptide amphiphile mixtures: controllable structural and mechanical properties and antimicrobial activity", Rsc Advances, 7, 8366 - 8375 (2017), DOI: 10.1039/C6RA27244D
- Marta Carroni, Matteo De March, Barbara Medagli, Ivet Krastanova, Ian A. Taylor, Heinz Amenitsch, Hiroyuchi Araki, Francesca M. Pisani, Ardan Patwardhan, Silvia Onesti, "New insights into the GINS complex explain the controversy between existing structural models", Scientific Reports, 7 (2017), DOI: 10.1038/srep40188
- Malgorzata Kozlowska, Aneta Tarczewska, Michał Jakób, Dominika Bystranowska, Michal Taube, Maciej Kozak, Mariusz Czarnocki-Cieciura, Andrzej Dziembowski, Marek Orłowski, Katarzyna Tkocz, Andrzej Ożyhar, "Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments", Scientific Reports, 7 (2017), DOI: 10.1038/srep40405
- Joseph A. Newman, Hazel Aitkenhead, Pavel Savitsky, Opher Gileadi, "Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5", Nucleic Acids Research (2017), DOI: 10.1093/nar/gkw1362
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