Robert Rambo


Robert Rambo is Science Group Leader for the Soft Condensed Matter village and former Principal Beamline Scientist for B21.

Email: [email protected]
Tel: +44 (0)1235 56 7675

Robert Rambo is the Principal Beamline Scientist (PBS) for the solution state SAXS beamline B21. During his Ph.D., Robert was trained as an RNA crystallographer in the laboratory of Jennifer A. Doudna at Yale University where he helped determine the structure of the bacterial signal recognition particle (SRP) and a structural role for potassium ions in the P4-P6 RNA domain (the organizational center for the group I intron). In addition, Robert’s thesis focused on protein-RNA assemblies providing key insights into the folding of protein-assisted group II introns.

After graduating, Robert worked briefly as a web-application programmer before starting his post-doctoral training at the Advanced Light Source with the SIBYLS beamline (a dual SAXS and MX development beamline headed by John A. Tainer of the Scripps Research Institute). Here, Robert helped establish standard purification methods for RNA SAXS experiments and developed new methods for analyzing SAXS data including the volume-of-correlation and chi-free.

Robert’s expertise is in applying new mathematical methods (convex optimization and semi-definite programming) to SAXS experiments. He is the author of Scâ„«tter, a java-based program for bioSAXS and creator of (a solution SAXS database).

Post-Doctoral Training
Advanced Light Source
Lawrence Berkeley National Laboratory,
Berkeley, CA, USA
PI: John Tainer

2003 Ph.D. Yale University
Department of Molecular Biophysics and Biochemistry
PI: Jennifer A. Doudna

1996 B.S. Mathematics and Chemistry
University of Alaska, Anchorage

Mason AC, Rambo RP, Greer B, Pritchett M, Tainer JA, Cortez D, Eichman BF.
Proc Natl Acad Sci U S A. 2014 May 27;111(21):7618-23. doi: 10.1073/pnas.1324143111. Epub 2014 May 12.
Strulson CA, Yennawar NH, Rambo RP, Bevilacqua PC.
Biochemistry. 2013 Nov 19;52(46):8187-97. doi: 10.1021/bi400816s. Epub 2013 Nov 4.
Hura GL, Budworth H, Dyer KN, Rambo RP, Hammel M, McMurray CT, Tainer JA.
Nat Methods. 2013 Jun;10(6):453-4. doi: 10.1038/nmeth.2453.
Rambo RP, Tainer JA.
Nature. 2013 Apr 25;496(7446):477-81. doi: 10.1038/nature12070.
Rambo RP, Tainer JA.
Annu Rev Biophys. 2013;42:415-41. doi: 10.1146/annurev-biophys-083012-130301. Epub 2013 Mar 11. Review.
Bétous R, Mason AC, Rambo RP, Bansbach CE, Badu-Nkansah A, Sirbu BM, Eichman BF, Cortez D.
Genes Dev. 2012 Jan 15;26(2):151-62. doi: 10.1101/gad.178459.111.
Kazantsev AV, Rambo RP, Karimpour S, Santalucia J Jr, Tainer JA, Pace NR.
RNA. 2011 Jun;17(6):1159-71. doi: 10.1261/rna.2563511. Epub 2011 Apr 29.
Rambo RP, Tainer JA.
Biopolymers. 2011 Aug;95(8):559-71. doi: 10.1002/bip.21638. Epub 2011 Apr 20.
Rambo RP, Williams GJ, Tainer JA.
Mol Cell. 2010 Nov 12;40(3):347-8. doi: 10.1016/j.molcel.2010.10.032.
Stoddard CD, Montange RK, Hennelly SP, Rambo RP, Sanbonmatsu KY, Batey RT.
Structure. 2010 Jul 14;18(7):787-97. doi: 10.1016/j.str.2010.04.006.

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