Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy B21 Contact
Beamline phone numbers:
+44 (0) 1235 77 8627
+44 (0) 1235 77 8640
Principal Beamline Scientist:
Nathan Cowieson
Tel: +44 (0) 1235 567 504
E-mail: [email protected]
Science Group Leader
Robert Rambo
Email: [email protected]
Tel: +44 (0)1235 56 7675
B21 High Throughput SAXS
Status: Operational
Beamsize: <75 μm
Detector: Eiger 4M
Energy: 6 - 23 keV
Detector: Eiger 4M
Energy: 6 - 23 keV
28 items found for 2026 [total: 654]
Glycoglycerolipid-coated F/ZnO quantum dots: A biocompatible amphiphilic formulation for fluorescent nanoprobes Colloids And Surfaces B: Biointerfaces, 264 Aug 2026 DOI: 10.1016/j.colsurfb.2026.115674
Journal Paper B21-High Throughput SAXS
The rise and fall of SARM1 base-exchange inhibitors Communications Chemistry, 9 May 2026 DOI: 10.1038/s42004-026-02074-8
Structural basis of the protein kinase PKN1 HR1 domain oligomerization and differential regulation by RhoA and Rac1 Journal Of Biological Chemistry, 117 Apr 2026 DOI: 10.1016/j.jbc.2026.112203
Hydroxyl radical footprinting modification reveals an intradomain communication pathway in EFL1 disrupted by a Shwachman‐Diamond syndrome‐associated mutation Protein Science, 35 Apr 2026 DOI: 10.1002/pro.70504
De novo design of chromophore-binding peptide assemblies and single-chain proteins Mar 2026
Thesis B21-High Throughput SAXS I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Novel palmitoyl pentapeptides: self-assembly, collagen stimulation, antioxidant activity, and influence of skin microbiota health Acs Omega, 274 Mar 2026 DOI: 10.1021/acsomega.5c12526
Lyophilized monoclonal antibody (mAb) encoded mRNA-lipid nanoparticles (LNPs) lead to stable in vivo expression of mAb after room temperature storage Aaps Open, 12 Mar 2026 DOI: 10.1186/s41120-026-00147-5
Fibrillar and micellar aggregation of semaglutide and formation of a chiral-imprinted glass Biomacromolecules, 309 Mar 2026 DOI: 10.1021/acs.biomac.5c02669
A novel cell-penetrating lipopeptide for DNA binding, self-assembly, and delivery into HeLa and pluripotent stem cells Journal Of Peptide Science, 32 Mar 2026 DOI: 10.1002/psc.70085
The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase Nature Communications, 142 Mar 2026 DOI: 10.1038/s41467-026-69833-y
Directional engineering of cyclic β-hairpin peptides for PET/CT imaging of PD-L1 Journal Of The American Chemical Society, Mar 2026 DOI: 10.1021/jacs.5c21595
Journal Paper B21-High Throughput SAXS
A bottom-up route to tunable nanophotonic materials via binary nanocrystal co-assembly Materials Today Nano, 147 Mar 2026 DOI: 10.1016/j.mtnano.2026.100803
A computational pipeline for generating SAXS-consistent atomistic protein ensembles Mar 2026
Thesis B21-High Throughput SAXS
Physicochemical principles governing the intrinsically disordered salivary peptide histatin 5: ensemble structure, electrostatics, and environmental responsiveness The Journal Of Physical Chemistry B, Mar 2026 DOI: 10.1021/acs.jpcb.6c00591
Cleavage region organizes the structural architecture of the SINE-derived B2 repressive ribozyme Communications Biology, 18 Mar 2026 DOI: 10.1038/s42003-026-09819-0
Structure-guided development of an electrochemical aptasensor for Salmonella Typhi HlyE antigen detection using in silico and experimental approaches Scientific Reports, 72 Feb 2026 DOI: 10.1038/s41598-026-38666-6
Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin Structure, 19 Feb 2026 DOI: 10.1016/j.str.2026.01.008
Human lncRNA RMRP interacts with DEAD-box helicases and modulates mitochondrial function Proceedings Of The National Academy Of Sciences, 123 Feb 2026 DOI: 10.1073/pnas.2522583123
Ion-induced morphological plasticity in a self-assembling peptide hydrogel Langmuir, 40 Feb 2026 DOI: 10.1021/acs.langmuir.5c05439
Journal Paper B21-High Throughput SAXS
Structure and mechanism of the HECT ligase HECTD3 Nature Communications, 81 Feb 2026 DOI: 10.1038/s41467-026-69520-y
Self-assembly of a therapeutic peptide surfactant: a small-angle X-ray scattering study Langmuir, Feb 2026 DOI: 10.1021/acs.langmuir.5c06529
Chiral glass formation by dipeptide salts Biomacromolecules, Feb 2026 DOI: 10.1021/acs.biomac.5c02634
An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6 Nature Communications, 22 Feb 2026 DOI: 10.1038/s41467-026-69789-z
The key role of soft corona in the superlattice formation of CeO2 nanoparticles Journal Of Materials Chemistry C, 17 Feb 2026 DOI: 10.1039/D5TC03467A
Integrative structural characterization of Candida glabrata phosphoglycerate kinase by small-angle X-ray scattering and AlphaFold: implications for therapeutic targeting in candidiasis Acs Omega, 374 Jan 2026 DOI: 10.1021/acsomega.5c11751
Development and optimization of resveratrol-loaded NLCs via low-energy methods: a promising alternative to conventional high-energy or solvent-based techniques Processes, 14 Jan 2026 DOI: 10.3390/pr14020393
Charge directed selective co-assembly of ionic complementary peptide binary mixtures Small, 21 Jan 2026 DOI: 10.1002/smll.202513140
Nanobodies as tools for studying human frataxin biology Communications Biology, 298 Jan 2026 DOI: 10.1038/s42003-025-09458-x
- Giuseppe Junior Mosca, Simone Russo, Valentina Pelliccioli, Martina Quaglia, Pietro Pettinari, Alessandro Cangiano, Diego Colombo, Paola Perego, Giovanni L. Beretta, Laura Morelli, Giuseppe Vitiello, "Glycoglycerolipid-coated F/ZnO quantum dots: A biocompatible amphiphilic formulation for fluorescent nanoprobes", Colloids And Surfaces B: Biointerfaces, 264 (2026), DOI: 10.1016/j.colsurfb.2026.115674
- Thomas Lundbäck, Vijay Chandrasekar, Chendi Gu, Hyoungseok Ju, Robyn Mcadam, Maria Palomero, Kasim Sader, Bradley Peter, Lisa Wissler, Philip Nevin, Edmund Foster, Tanguy Jamier, Pravallika Manjappa, Carina Johansson, Jenny Sandmark, Mei Ding, Anette Persson-Kry, Sanhita Mitra, Tugce Munise Satir, Bilada Bilican, Mirko Messa, Graham Fraser, John Linley, Helen Plant, Rachel Moore, Tina Seifert, Michael Lerche, Carina Raynochek, Ewa Nilsson, Nour Majbour, Richard Lucey, Taiana Maia De Oliveira, Qi Wang, Iain Chessell, Perla Breccia, Rebecca Jarvis, "The rise and fall of SARM1 base-exchange inhibitors", Communications Chemistry, 9 (2026), DOI: 10.1038/s42004-026-02074-8
- Georgios Sophocleous, Darerca Owen, Helen R. Mott, "Structural basis of the protein kinase PKN1 HR1 domain oligomerization and differential regulation by RhoA and Rac1", Journal Of Biological Chemistry, 117 (2026), DOI: 10.1016/j.jbc.2026.112203
- Jonathan A. Zúñiga-Domínguez, Rohit Jain, Martín González-Andrade, Erik R. Farquhar, Mark R. Chance, Abril Gijsbers, Nuria Sanchez-Puig, "Hydroxyl radical footprinting modification reveals an intradomain communication pathway in EFL1 disrupted by a Shwachman‐Diamond syndrome‐associated mutation", Protein Science, 35 (2026), DOI: 10.1002/pro.70504
- [Thesis] Rokas Petrenas, "De novo design of chromophore-binding peptide assemblies and single-chain proteins" (2026)
- Juliane N. B. D. Pelin, Lucas R. De Mello, Raquel Allen Garcia Barbeto Siqueira, Matheus De Souza Alves, Valeria Castelletto, João Francisco Almeida, Jani Seitsonen, Patricia Santos Lopes, Vânia Leite-Silva, Newton Andreo-Filho, Ian W. Hamley, "Novel palmitoyl pentapeptides: self-assembly, collagen stimulation, antioxidant activity, and influence of skin microbiota health", Acs Omega, 274 (2026), DOI: 10.1021/acsomega.5c12526
- Zimeng Wang, Bei Cheng, Christine Tkaczyk, Michael Newton, Shuolin Cui, Bohdan Andreiuk, Sanjib Saha, Sabrina Khan, Charles Chen, Bin Yang, Adam Gamson, Sarah Siddiqui, George Thom, Antonio Digiandomenico, Liping Zhou, "Lyophilized monoclonal antibody (mAb) encoded mRNA-lipid nanoparticles (LNPs) lead to stable in vivo expression of mAb after room temperature storage", Aaps Open, 12 (2026), DOI: 10.1186/s41120-026-00147-5
- Valeria Castelletto, Lucas R. De Mello, Jani Seitsonen, Ian W. Hamley, "Fibrillar and micellar aggregation of semaglutide and formation of a chiral-imprinted glass", Biomacromolecules, 309 (2026), DOI: 10.1021/acs.biomac.5c02669
- Lucas R. De Mello, Tâmisa seeko bandeira Honda, Valeria Castelletto, Patrícia terra Alves, Sang Won Han, Emerson Rodrigo Da Silva, Ian W. Hamley, "A novel cell-penetrating lipopeptide for DNA binding, self-assembly, and delivery into HeLa and pluripotent stem cells", Journal Of Peptide Science, 32 (2026), DOI: 10.1002/psc.70085
- Ana Martín-Hurtado, Julia Contreras, Jana Sánchez-Wandelmer, Eduardo Zarzuela, Fernando García, Johanne Le Coq, Jasminka Boskovic, Ines G. Munoz, Federico Gago, Javier Muñoz, Marta Isasa, Ivan Plaza-Menacho, "The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase", Nature Communications, 142 (2026), DOI: 10.1038/s41467-026-69833-y
- Can Liu, Siqi Zhang, Jianan Chen, Hao Geng, Hongwei Li, Zirui Zhang, Qingshuang Lu, Liyuan Xu, Jiang Li, Hailong Zhang, Lu Wang, Ming-Rong Zhang, Yundong Wu, Rui Wang, Kuan Hu, "Directional engineering of cyclic β-hairpin peptides for PET/CT imaging of PD-L1", Journal Of The American Chemical Society (2026), DOI: 10.1021/jacs.5c21595
- Alessandro Cangiano, Noemi Gallucci, Nathan Cowieson, Luigi Paduano, "A bottom-up route to tunable nanophotonic materials via binary nanocrystal co-assembly", Materials Today Nano, 147 (2026), DOI: 10.1016/j.mtnano.2026.100803
- [Thesis] Cameron L. Brown, "A computational pipeline for generating SAXS-consistent atomistic protein ensembles" (2026)
- Oskar Svensson, Samuel Lenton, Marie Skepö, "Physicochemical principles governing the intrinsically disordered salivary peptide histatin 5: ensemble structure, electrostatics, and environmental responsiveness", The Journal Of Physical Chemistry B (2026), DOI: 10.1021/acs.jpcb.6c00591
- Ankush Singhal, Tyler Mrozowich, Carlos Rivera, Susmit Narayan Chaudhury, Lilei Xu, Rodrigo Aguilar, Maulik Badmalia, Jeannie T. Lee, Trushar R. Patel, Karissa Y. Sanbonmatsu, "Cleavage region organizes the structural architecture of the SINE-derived B2 repressive ribozyme", Communications Biology, 18 (2026), DOI: 10.1038/s42003-026-09819-0
- Mohamad Ahmad Najib, Anja Winter, Khairul Mohd Fadzli Mustaffa, Muhammad Hafiznur Yunus, Eugene Boon Beng Ong, Kasturi Selvam, Muhammad Fazli Khalid, Mohd Syafiq Awang, Asrulnizam Abd Manaf, Yazmin Bustami, Habibah A. Wahab, Ismail Aziah, "Structure-guided development of an electrochemical aptasensor for Salmonella Typhi HlyE antigen detection using in silico and experimental approaches", Scientific Reports, 72 (2026), DOI: 10.1038/s41598-026-38666-6
- Gauri Deak, Hayden Burdett, James Watson, Marcus D. Wilson, "Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin", Structure, 19 (2026), DOI: 10.1016/j.str.2026.01.008
- Higor Sette Pereira, Jason Luddu, Govardhan Reddy Veerareddygari, Shridhar Kiran Sanghvi, Priyanshi B. Patel, Zachary E. Robinson, M. Quadir Siddiqui, Harpreet Singh, Trushar R. Patel, "Human lncRNA RMRP interacts with DEAD-box helicases and modulates mitochondrial function", Proceedings Of The National Academy Of Sciences, 123 (2026), DOI: 10.1073/pnas.2522583123
- Biplab Mondal, Tanushree Mondal, Anushree Sinha, Ian W. Hamley, Susmita Roy, Arindam Banerjee, "Ion-induced morphological plasticity in a self-assembling peptide hydrogel", Langmuir, 40 (2026), DOI: 10.1021/acs.langmuir.5c05439
- Jessica Huber, Diego Esposito, Sarah Maslen, Dominic O. Chambers, J. Mark Skehel, Katrin Rittinger, "Structure and mechanism of the HECT ligase HECTD3", Nature Communications, 81 (2026), DOI: 10.1038/s41467-026-69520-y
- Ellen Brunzell, Kalle Sigfridsson, L. Magnus Bergström, "Self-assembly of a therapeutic peptide surfactant: a small-angle X-ray scattering study", Langmuir (2026), DOI: 10.1021/acs.langmuir.5c06529
- Valeria Castelletto, Ian W. Hamley, "Chiral glass formation by dipeptide salts", Biomacromolecules (2026), DOI: 10.1021/acs.biomac.5c02634
- Federica Capraro, Giancarlo Abis, Alessio Incocciati, Peter J. Simpson, Mehran Karimzadeh, Laura Masino, Alexander Barley, Tam T. T. Bui, Geoff Kelly, Hani Goodarzi, Maria R. Conte, Faraz K. Mardakheh, "An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6", Nature Communications, 22 (2026), DOI: 10.1038/s41467-026-69789-z
- Noemi Gallucci, Alessandro Cangiano, Rosario Oliva, Donato Ciccarelli, Gennaro Rollo, Rocco Di Girolamo, Nathan Cowieson, Giuseppe Vitiello, Luigi Paduano, "The key role of soft corona in the superlattice formation of CeO2 nanoparticles", Journal Of Materials Chemistry C, 17 (2026), DOI: 10.1039/D5TC03467A
- Mayra Cuéllar-Cruz, Edson E. Maqueda Cabrera, Dritan Siliqi, Abel Moreno, "Integrative structural characterization of Candida glabrata phosphoglycerate kinase by small-angle X-ray scattering and AlphaFold: implications for therapeutic targeting in candidiasis", Acs Omega, 374 (2026), DOI: 10.1021/acsomega.5c11751
- Nicoly T. R. Britto, Lilian R. S. Montanheri, Juliane N. B. D. Pelin, Raquel A. G. B. Siqueira, Matheus De Souza Alves, Tereza S. Martins, Ian W. Hamley, Patrícia S. Lopes, Vânia R. Leite-Silva, Newton Andreo-Filho, "Development and optimization of resveratrol-loaded NLCs via low-energy methods: a promising alternative to conventional high-energy or solvent-based techniques", Processes, 14 (2026), DOI: 10.3390/pr14020393
- Abdulwahhab Khedr, Mohamed A. N. Soliman, Alfred Corrigan, Tarsem Sahota, Rachel Armitage, Natalie Allcock, Jeyapriya T. Jegadeesan, Mahetab H. Amer, Reem Alazragi, Zeeshan Ahmad, Jacek K. Wychowaniec, Mohamed A. Elsawy, "Charge directed selective co-assembly of ionic complementary peptide binary mixtures", Small, 21 (2026), DOI: 10.1002/smll.202513140
- María Florencia Pignataro, Natalia Brenda Fernández, Alba Garay-Alvarez, María Florencia Pavan, Rafael Molina, Ines G. Munoz, Julián Grossi, Martín Noguera, Antonella Vila, Augusto E. García, Hernán G. Gentili, Naira Antonia Rodríguez, Martín Aran, Viviana Parreño, Marina Bok, Juan A. Hermoso, Lorena Itatí Ibañez, Javier Santos, "Nanobodies as tools for studying human frataxin biology", Communications Biology, 298 (2026), DOI: 10.1038/s42003-025-09458-x
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