Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy B21 Contact
Beamline phone numbers:
+44 (0) 1235 77 8627
+44 (0) 1235 77 8640
Principal Beamline Scientist:
Nathan Cowieson
Tel: +44 (0) 1235 567 504
E-mail: [email protected]
Science Group Leader
Robert Rambo
Email: [email protected]
Tel: +44 (0)1235 56 7675
B21 High Throughput SAXS
Status: Operational
Beamsize: <75 μm
Detector: Eiger 4M
Energy: 6 - 23 keV
Detector: Eiger 4M
Energy: 6 - 23 keV
69 items found for 2021 [total: 654]
Self-assembling behaviour of the peptide hormone PYY3-36 and its lipidated conjugates for future applications in controlling satiety levels Dec 2021
Thesis B21-High Throughput SAXS I22-Small angle scattering & Diffraction
A rationally designed supercharged protein-enzyme chimera self-assembles in situ to yield bifunctional composite textiles Acs Applied Materials & Interfaces, Dec 2021 DOI: 10.1021/acsami.1c18857
Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12 Communications Biology, 4 Dec 2021 DOI: 10.1038/s42003-021-02887-4
Molecular characterisation of eIF4A paralogues Dec 2021
Thesis B21-High Throughput SAXS
Tackling the root causes of Alzheimer's disease Dec 2021
Science Highlight B21-High Throughput SAXS
Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding Nature Communications, 12 Nov 2021 DOI: 10.1038/s41467-021-26584-2
Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus, an essential component of the divisome machinery Computational And Structural Biotechnology Journal, 19 Oct 2021 DOI: 10.1016/j.csbj.2021.09.018
Recombinant protein for diagnostic purposes: expression optimization, purification and structural characterization Oct 2021
Thesis B21-High Throughput SAXS
Structural basis for the inhibition of the Bacillus subtilis c-di-AMP cyclase CdaA by the phosphoglucomutase GlmM Journal Of Biological Chemistry, 198 Oct 2021 DOI: 10.1016/j.jbc.2021.101317
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Lipid cubic systems for sustained and controlled delivery of antihistamine drugs Molecular Pharmaceutics, 3 Sept 2021 DOI: 10.1021/acs.molpharmaceut.1c00279
Ciprofibrate-loaded nanoparticles prepared by nanoprecipitation: Synthesis, characterization, and drug release Polymers, 13 Sept 2021 DOI: 10.3390/polym13183158
Activity of lymphostatin, a lymphocyte inhibitory virulence factor of pathogenic Escherichia coli, is dependent on a cysteine protease motif Journal Of Molecular Biology, 433 Sept 2021 DOI: 10.1016/j.jmb.2021.167200
Balanced lipase interactions for degradation-controlled paclitaxel release from lipid cubic phase formulations Journal Of Colloid And Interface Science, 31 Sept 2021 DOI: 10.1016/j.jcis.2021.09.024
Multi‐scale ensemble properties of the Escherichia coli RNA degradosome Molecular Microbiology, 8 Sept 2021 DOI: 10.1111/mmi.14800
Palmitic acid sophorolipid biosurfactant: from self-assembled fibrillar network (SAFiN) to hydrogels with fast recovery Philosophical Transactions Of The Royal Society A: Mathematical, Physical And Engineering Sciences, 379 Sept 2021 DOI: 10.1098/rsta.2020.0343
Journal Paper B21-High Throughput SAXS
Talin rod domain–containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation Journal Of Cell Biology, 220 Sept 2021 DOI: 10.1083/jcb.202005214
Autosomal recessive cutis Laxa 1C mutations disrupt the structure and interactions of latent TGFβ binding protein-4 Frontiers In Genetics, 12 Sept 2021 DOI: 10.3389/fgene.2021.706662
Self-assembly of azobenzene photosurfactants and the relationship with macroscopic properties Sept 2021 DOI: 10.17863/CAM.78808
High conformational flexibility of the E2F1/DP1/DNA complex Journal Of Molecular Biology, 433 Sept 2021 DOI: 10.1016/j.jmb.2021.167119
Journal Paper B21-High Throughput SAXS
Structural insights into the substrate-binding proteins Mce1A and Mce4A from Mycobacterium tuberculosis Iucrj, 8 Sept 2021 DOI: 10.1107/S2052252521006199
Molecular IgG3 structure paves the way for new applications of antibodies Sept 2021
Science Highlight B21-High Throughput SAXS
Peptide nanoparticles for gene packaging and intracellular delivery Aug 2021 DOI: 10.1007/978-1-0716-0928-6_3
Book Chapter B21-High Throughput SAXS
The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites Life Science Alliance, 4 Aug 2021 DOI: 10.26508/lsa.202101152
Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12 Nature Structural & Molecular Biology, 7 Aug 2021 DOI: 10.1038/s41594-021-00636-z
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A structural study of the cytoplasmic chaperone effect of 14-3-3 proteins on Ataxin-1 Journal Of Molecular Biology, 9 Jul 2021 DOI: 10.1016/j.jmb.2021.167174
Order from disorder with intrinsically disordered peptide amphiphiles Journal Of The American Chemical Society, 2010 Jul 2021 DOI: 10.1021/jacs.1c06133
Priming human elastic proteins for assembly into elastic tissues Jul 2021
Diamond Annual Review Highlight B21-High Throughput SAXS
Molecular mechanism of quorum sensing inhibition in Streptococcus by the phage protein paratox Journal Of Biological Chemistry, 369 Jul 2021 DOI: 10.1016/j.jbc.2021.100992
Design and characterization of monoacylglycerol lipid cubic phase systems for the effective delivery of small molecule pharmaceuticals Jul 2021
Thesis B21-High Throughput SAXS
Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses Journal Of Biological Chemistry, 40 Jul 2021 DOI: 10.1016/j.jbc.2021.100995
Interaction studies of human DEAD-box helicases with viral non-coding RNA Jul 2021
Thesis B21-High Throughput SAXS
Notch–Jagged signaling complex defined by an interaction mosaic Proceedings Of The National Academy Of Sciences, 118 Jul 2021 DOI: 10.1073/pnas.2102502118
Guanylate Cyclase Activating Protein 1 monomer-dimer equilibrium controlled by Ca2+ or Mg2+ binding: hints to understand retinal Guanylate Cyclase regulation Jul 2021
Thesis B21-High Throughput SAXS
Impact of subtle change in branched amino acid on the assembly and properties of perylene bisimides hydrogels Materials Advances, 23 Jul 2021 DOI: 10.1039/D1MA00470K
New details about a key COVID-19 protein could help us stop the virus Jul 2021
Science Highlight B21-High Throughput SAXS
Structural basis for the coiled-coil architecture of human CtIP Open Biology, 11 June 2021 DOI: 10.1098/rsob.210060
Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae Acta Crystallographica Section D Structural Biology, 77 June 2021 DOI: 10.1107/S2059798321004149
Periscope Proteins are variable-length regulators of bacterial cell surface interactions Proceedings Of The National Academy Of Sciences, 118 June 2021 DOI: 10.1073/pnas.2101349118
An artificial membrane binding protein-polymer surfactant nanocomplex facilitates stem cell adhesion to the cartilage extracellular matrix Biomaterials, 5 June 2021 DOI: 10.1016/j.biomaterials.2021.120996
Human myelin protein P2: From crystallography to time‐lapse membrane imaging and neuropathy‐associated variants The Febs Journal, June 2021 DOI: 10.1111/febs.16079
A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection Scientific Reports, 11 May 2021 DOI: 10.1038/s41598-021-89957-z
Probing the oligomeric re-assembling of bacterial fimbriae in vitro: a small-angle X-ray scattering and analytical ultracentrifugation study European Biophysics Journal, 39 May 2021 DOI: 10.1007/s00249-021-01543-3
Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc Plos One, 16 May 2021 DOI: 10.1371/journal.pone.0251459
Structural basis of FANCD2 deubiquitination by USP1−UAF1 Nature Structural & Molecular Biology, 18 Apr 2021 DOI: 10.1038/s41594-021-00576-8
Solution and membrane interaction dynamics of Mycobacterium tuberculosis fatty Acyl-CoA synthetase FadD13 Biochemistry, Apr 2021 DOI: 10.1021/acs.biochem.0c00987
The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors Scientific Reports, 11 Apr 2021 DOI: 10.1038/s41598-021-88630-9
Inference of molecular structure for characterization and improvement of clinical grade immunocytokines Journal Of Structural Biology, 213 Mar 2021 DOI: 10.1016/j.jsb.2021.107696
Journal Paper B21-High Throughput SAXS
An Fc-free EGFR-specific 4-1BB-agonistic trimerbody displays broad anti-tumor activity in humanized murine cancer models without toxicity Clinical Cancer Research, Mar 2021 DOI: 10.1158/1078-0432.CCR-20-4625
Journal Paper B21-High Throughput SAXS
Discriminative SKP2 interactions with CDK-cyclin complexes support a cyclin a-specific role in p27KIP1 degradation Journal Of Molecular Biology, 433 Mar 2021 DOI: 10.1016/j.jmb.2020.166795
Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) open access
Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA Journal Of Biological Chemistry, 61 Mar 2021 DOI: 10.1016/j.jbc.2021.100589
Impact of arginine–phosphate interactions on the reentrant condensation of disordered proteins Biomacromolecules, Mar 2021 DOI: 10.1021/acs.biomac.0c01765
Solution structure of deglycosylated human IgG1 shows the role of CH2 glycans in its conformation Biophysical Journal, Mar 2021 DOI: 10.1016/j.bpj.2021.02.038
Journal Paper B21-High Throughput SAXS
Simultaneous binding of guidance cues NET1 and RGM blocks extracellular NEO1 signaling Cell, 74 Mar 2021 DOI: 10.1016/j.cell.2021.02.045
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography Krios IV-Titan Krios IV at Diamond open access
Modulation of human phenylalanine hydroxylase by 3-hydroxyquinolin-2(1h)-one derivatives Biomolecules, 11 Mar 2021 DOI: 10.3390/biom11030462
Conjuring up a ghost: structural and functional characterization of FhuF, a ferric siderophore reductase from E. coli Jbic Journal Of Biological Inorganic Chemistry, 361 Feb 2021 DOI: 10.1007/s00775-021-01854-y
Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family Elife, 10 Feb 2021 DOI: 10.7554/eLife.61818
A common SNP risk variant MT1-MMP causative for Dupuytren's Disease has a specific defect in collagenolytic activity Matrix Biology, 81 Feb 2021 DOI: 10.1016/j.matbio.2021.02.003
Journal Paper B21-High Throughput SAXS
Unexpected diversity of ferredoxin-dependent thioredoxin reductases in cyanobacteria Plant Physiology, Feb 2021 DOI: 10.1093/plphys/kiab072
Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) open access
A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies Elife, 10 Jan 2021 DOI: 10.7554/eLife.60175
Journal Paper B21-High Throughput SAXS I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure of the complete dimeric human GDAP1 core domain provides insights into ligand binding and clustering of disease mutations Frontiers In Molecular Biosciences, 7 Jan 2021 DOI: 10.3389/fmolb.2020.631232
Journal Paper B21-High Throughput SAXS I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM Nature Methods, 18 Jan 2021 DOI: 10.1038/s41592-020-01001-6
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Solution structure and conformational dynamics of a doublet acyl carrier protein from prodigiosin biosynthesis Biochemistry, Jan 2021 DOI: 10.1021/acs.biochem.0c00830
Journal Paper B21-High Throughput SAXS
The potential of caffeic acid lipid nanoparticulate systems for skin application: in vitro assays to assess delivery and antioxidant effect Nanomaterials, 11 Jan 2021 DOI: 10.3390/nano11010171
Crystal and solution structure of NDRG1, a membrane‐binding protein linked to myelination and tumour suppression The Febs Journal, 21 Jan 2021 DOI: 10.1111/febs.15660
Structural characterisation of a carbohydrate binding domain of the human cation-independent mannose 6-phosphate/ IGF2 receptor Jan 2021
Thesis B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Human DDX17 unwinds rift valley fever virus non-coding RNAs International Journal Of Molecular Sciences, 22 Jan 2021 DOI: 10.3390/ijms22010054
Simulation informed design of stimuli responsive structures and higher-order assemblies in DNA nanotechnology Jan 2021 DOI: 10.17863/CAM.78563
Thesis B21-High Throughput SAXS
Study of the interaction between the influenza A virus polymerase and GTPase Rab11a Jan 2021
Thesis B21-High Throughput SAXS B24-Cryo Soft X-ray Tomography
- [Thesis] Samuel Burholt, "Self-assembling behaviour of the peptide hormone PYY3-36 and its lipidated conjugates for future applications in controlling satiety levels" (2021)
- Graham J. Day, William H. Zhang, Ben M. Carter, Wenjin Xiao, Mark R. Sambrook, Adam W. Perriman, "A rationally designed supercharged protein-enzyme chimera self-assembles in situ to yield bifunctional composite textiles", Acs Applied Materials & Interfaces (2021), DOI: 10.1021/acsami.1c18857
- Sumit Sandhu, Ieng F. Sou, Jill E. Hunter, Lucy Salmon, Caroline L. Wilson, Neil D. Perkins, Neil Hunter, Owen R. Davies, Urszula L. Mcclurg, "Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12", Communications Biology, 4 (2021), DOI: 10.1038/s42003-021-02887-4
- [Thesis] Adrianna Dabrowska, "Molecular characterisation of eIF4A paralogues" (2021)
- [Science Highlight] Diamond Light Source, "Tackling the root causes of Alzheimer's disease" (2021)
- Guilherme G. Moreira, François-Xavier Cantrelle, Andrea Quezada, Filipa S. Carvalho, Joana S. Cristóvão, Urmi Sengupta, Nicha Puangmalai, Ana P. Carapeto, Mário S. Rodrigues, Isabel Cardoso, Guenter Fritz, Federico Herrera, Rakez Kayed, Isabelle Landrieu, Cláudio M. Gomes, "Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding", Nature Communications, 12 (2021), DOI: 10.1038/s41467-021-26584-2
- Siseth Martínez-Caballero, Kiran V. Mahasenan, Choon Kim, Rafael Molina, Rhona Feltzer, Mijoon Lee, Renee Bouley, Dusan Hesek, Jed F. Fisher, Ines G. Munoz, Mayland Chang, Shahriar Mobashery, Juan A. Hermoso, "Integrative structural biology of the penicillin-binding protein-1 from Staphylococcus aureus, an essential component of the divisome machinery", Computational And Structural Biotechnology Journal, 19, 5392 - 5405 (2021), DOI: 10.1016/j.csbj.2021.09.018
- [Thesis] Lucrezia Savini, "Recombinant protein for diagnostic purposes: expression optimization, purification and structural characterization" (2021)
- Monisha Pathania, Tommaso Tosi, Charlotte Millership, Fumiya Hoshiga, Rhodri M.l. Morgan, Paul Freemont, Angelika Gründling, "Structural basis for the inhibition of the Bacillus subtilis c-di-AMP cyclase CdaA by the phosphoglucomutase GlmM", Journal Of Biological Chemistry, 198 (2021), DOI: 10.1016/j.jbc.2021.101317
- Michele Dully, Miriama Ceresnakova, David Murray, Tewfik Soulimane, Sarah P. Hudson, "Lipid cubic systems for sustained and controlled delivery of antihistamine drugs", Molecular Pharmaceutics, 3 (2021), DOI: 10.1021/acs.molpharmaceut.1c00279
- Raissa Lohanna Gomes Quintino Corrêa, Renan Dos Santos, Lindomar José Calumby Albuquerque, Gabriel Lima Barros De Araujo, Charlotte Jennifer Edwards-Gayle, Fabio Furlan Ferreira, Fanny Nascimento Costa, "Ciprofibrate-loaded nanoparticles prepared by nanoprecipitation: Synthesis, characterization, and drug release", Polymers, 13 (2021), DOI: 10.3390/polym13183158
- Matthias Wälchli, Karolin Berneiser, Francesca Mangia, Stefan Imseng, Louise-Marie Craigie, Edward Stuttfeld, Michael N. Hall, Timm Maier, "Regulation of human mTOR complexes by DEPTOR", Elife, 10 (2021), DOI: 10.7554/eLife.70871
- Andrew G. Bease, Elizabeth A. Blackburn, Cosmin Chintoan-Uta, Shaun Webb, Robin L. Cassady-Cain, Mark P. Stevens, "Activity of lymphostatin, a lymphocyte inhibitory virulence factor of pathogenic Escherichia coli, is dependent on a cysteine protease motif", Journal Of Molecular Biology, 433 (2021), DOI: 10.1016/j.jmb.2021.167200
- Michele Dully, Shayon Bhattacharya, Vivek Verma, David Murray, Damien Thompson, Tewfik Soulimane, Sarah P. Hudson, "Balanced lipase interactions for degradation-controlled paclitaxel release from lipid cubic phase formulations", Journal Of Colloid And Interface Science, 31 (2021), DOI: 10.1016/j.jcis.2021.09.024
- Tom Dendooven, Giulia Paris, Alexander V. Shkumatov, Md. Saiful Islam, Alister Burt, Marta A. Kubańska, Tai Yuchen Yang, Steven W. Hardwick, Ben F. Luisi, "Multi‐scale ensemble properties of the Escherichia coli RNA degradosome", Molecular Microbiology, 8 (2021), DOI: 10.1111/mmi.14800
- Niki Baccile, Ghazi Ben Messaoud, Patrick Le Griel, Nathan Cowieson, Javier Perez, Robin Geys, Marilyn De Graeve, Sophie L. K. W. Roelants, Wim Soetaert, "Palmitic acid sophorolipid biosurfactant: from self-assembled fibrillar network (SAFiN) to hydrogels with fast recovery", Philosophical Transactions Of The Royal Society A: Mathematical, Physical And Engineering Sciences, 379 (2021), DOI: 10.1098/rsta.2020.0343
- Alana R. Cowell, Guillaume Jacquemet, Abhimanyu Singh, Lorena Varela, Anna S. Nylund, York-Christoph Ammon, David Brown, Anna Akhmanova, Johanna Ivaska, Benjamin T. Goult, "Talin rod domain–containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation", Journal Of Cell Biology, 220 (2021), DOI: 10.1083/jcb.202005214
- Yasmene F. Alanazi, Michael P. Lockhart-Cairns, Stuart A. Cain, Thomas A. Jowitt, Anthony S. Weiss, Clair Baldock, "Autosomal recessive cutis Laxa 1C mutations disrupt the structure and interactions of latent TGFβ binding protein-4", Frontiers In Genetics, 12 (2021), DOI: 10.3389/fgene.2021.706662
- [Thesis] Elaine Kelly, "Self-assembly of azobenzene photosurfactants and the relationship with macroscopic properties" (2021), DOI: 10.17863/CAM.78808
- Dana Saad, Cristina Paissoni, Antonio Chaves-Sanjuan, Marco Nardini, Roberto Mantovani, Nerina Gnesutta, Carlo Camilloni, "High conformational flexibility of the E2F1/DP1/DNA complex", Journal Of Molecular Biology, 433 (2021), DOI: 10.1016/j.jmb.2021.167119
- Pooja Asthana, Dhirendra Singh, Jan Skov Pedersen, Mikko J. Hynonen, Ramita Sulu, Abhinandan V. Murthy, Mikko Laitaoja, Janne Jänis, Lee W. Riley, Rajaram Venkatesan, "Structural insights into the substrate-binding proteins Mce1A and Mce4A from Mycobacterium tuberculosis", Iucrj, 8 (2021), DOI: 10.1107/S2052252521006199
- [Science Highlight] Diamond Light Source, "Molecular IgG3 structure paves the way for new applications of antibodies" (2021)
- [Book Chapter] Maxim G. Ryadnov, Paula Vila-Gómez, James E. Noble, "Peptide nanoparticles for gene packaging and intracellular delivery" (2021), DOI: 10.1007/978-1-0716-0928-6_3
- Juan L Benavente, Dritan Siliqi, Lourdes Infantes, Laura Lagartera, Alberto Mills, Federico Gago, Noemí Ruiz-López, Miguel A Botella, Maria J. Sanchez-Barrena, Armando Albert, "The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites", Life Science Alliance, 4 (2021), DOI: 10.26508/lsa.202101152
- James M. Dunce, Lucy J. Salmon, Owen R. Davies, "Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12", Nature Structural & Molecular Biology, 7 (2021), DOI: 10.1038/s41594-021-00636-z
- Seppe Leysen, Rebecca Jane Burnley, Elizabeth Rodriguez, Lech-Gustav Milroy, Lorenzo Soini, Carolyn J. Adamski, Larissa Nitschke, Rachel Davis, Tomas Obsil, Lucas Brunsveld, Tom Crabbe, Huda Yahya Zoghbi, Christian Ottmann, Jeremy Martin Davis, "A structural study of the cytoplasmic chaperone effect of 14-3-3 proteins on Ataxin-1", Journal Of Molecular Biology, 9 (2021), DOI: 10.1016/j.jmb.2021.167174
- Guy Jacoby, Merav Segal Asher, Tamara Ehm, Inbal Abutbul Ionita, Hila Shinar, Salome Azoulay-Ginsburg, Ido Zemach, Gil Koren, Dganit Danino, Michael M. Kozlov, Roey J. Amir, Roy Beck, "Order from disorder with intrinsically disordered peptide amphiphiles", Journal Of The American Chemical Society, 2010 (2021), DOI: 10.1021/jacs.1c06133
- [Diamond Annual Review Highlight] Clair Baldock, "Priming human elastic proteins for assembly into elastic tissues" (2021)
- Nicole R. Rutbeek, Hanieh Rezasoltani, Trushar R. Patel, Mazdak Khajehpour, Gerd Prehna, "Molecular mechanism of quorum sensing inhibition in Streptococcus by the phage protein paratox", Journal Of Biological Chemistry, 369 (2021), DOI: 10.1016/j.jbc.2021.100992
- [Thesis] Michele Dully, "Design and characterization of monoacylglycerol lipid cubic phase systems for the effective delivery of small molecule pharmaceuticals" (2021)
- Valentina A. Spiteri, Margaret Goodall, James Doutch, Robert P. Rambo, Jayesh Gor, Stephen J. Perkins, "Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses", Journal Of Biological Chemistry, 40 (2021), DOI: 10.1016/j.jbc.2021.100995
- [Thesis] Corey Rhys Nelson, "Interaction studies of human DEAD-box helicases with viral non-coding RNA" (2021)
- Matthieu R. Zeronian, Oleg Klykov, Júlia Portell I De Montserrat, Maria J. Konijnenberg, Anamika Gaur, Richard A. Scheltema, Bert Janssen, "Notch–Jagged signaling complex defined by an interaction mosaic", Proceedings Of The National Academy Of Sciences, 118 (2021), DOI: 10.1073/pnas.2102502118
- [Thesis] Francesco Boni, "Guanylate Cyclase Activating Protein 1 monomer-dimer equilibrium controlled by Ca2+ or Mg2+ binding: hints to understand retinal Guanylate Cyclase regulation" (2021)
- Jacquelyn G. Egan, Glen Brodie, Daniel Mcdowall, Andrew J. Smith, Charlotte J. C. Edwards-Gayle, Emily R. Draper, "Impact of subtle change in branched amino acid on the assembly and properties of perylene bisimides hydrogels", Materials Advances, 23 (2021), DOI: 10.1039/D1MA00470K
- [Science Highlight] Diamond Light Source, "New details about a key COVID-19 protein could help us stop the virus" (2021)
- C. R. Morton, N. J. Rzechorzek, J. D. Maman, M. Kuramochi, H. Sekiguchi, R. Rambo, Y. C. Sasaki, O. R. Davies, Luca Pellegrini, "Structural basis for the coiled-coil architecture of human CtIP", Open Biology, 11 (2021), DOI: 10.1098/rsob.210060
- Jahangir Alam, Farah Tazkera Rahman, Shiv Sah-Teli, Rajaram Venkatesan, M. Kristian Koski, Kaija J. Autio, J. Kalervo Hiltunen, Alexander J. Kastaniotis, "Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae", Acta Crystallographica Section D Structural Biology, 77 (2021), DOI: 10.1107/S2059798321004149
- Fiona Whelan, Aleix Lafita, James Gilburt, Clement Degut, Samuel C. Griffiths, Huw Jenkins, Alexander N. St John, Emanuele Paci, James W. B. Moir, Michael J. Plevin, Christoph G. Baumann, Alex Bateman, Jennifer R. Potts, "Periscope Proteins are variable-length regulators of bacterial cell surface interactions", Proceedings Of The National Academy Of Sciences, 118 (2021), DOI: 10.1073/pnas.2101349118
- Rosalia Cuahtecontzi-Delint, Graham J. Day, William J. P. Macalester, Wael Kafienah, Wenjin Xiao, Adam W. Perriman, "An artificial membrane binding protein-polymer surfactant nanocomplex facilitates stem cell adhesion to the cartilage extracellular matrix", Biomaterials, 5 (2021), DOI: 10.1016/j.biomaterials.2021.120996
- Maiju Uusitalo, Martin Berg Klenow, Saara Laulumaa, Matthew P. Blakeley, Adam Cohen Simonsen, Salla Ruskamo, Petri Kursula, "Human myelin protein P2: From crystallography to time‐lapse membrane imaging and neuropathy‐associated variants", The Febs Journal (2021), DOI: 10.1111/febs.16079
- Ami Miller, Adam Leach, Jemima Thomas, Craig Mcandrew, Emma Bentley, Giada Mattiuzzo, Lijo John, Ali Mirazimi, Gemma Harris, Nadisha Gamage, Stephen Carr, Hanif Ali, Rob Van Montfort, Terence Rabbitts, "A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection", Scientific Reports, 11 (2021), DOI: 10.1038/s41598-021-89957-z
- Alexandra S. Solovyova, Daniel T. Peters, Gema Dura, Helen Waller, Jeremy H. Lakey, David A. Fulton, "Probing the oligomeric re-assembling of bacterial fimbriae in vitro: a small-angle X-ray scattering and analytical ultracentrifugation study", European Biophysics Journal, 39 (2021), DOI: 10.1007/s00249-021-01543-3
- Erik I. Hallin, Sigurbjorn Markusson, Lev Böttger, Andrew E. Torda, Clive R. Bramham, Petri Kursula, "Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc", Plos One, 16 (2021), DOI: 10.1371/journal.pone.0251459
- Martin L. Rennie, Connor Arkinson, Viduth K. Chaugule, Rachel Toth, Helen Walden, "Structural basis of FANCD2 deubiquitination by USP1−UAF1", Nature Structural & Molecular Biology, 18 (2021), DOI: 10.1038/s41594-021-00576-8
- Camilla A. K. Lundgren, Michael Lerche, Charlotta Norling, Martin Högbom, "Solution and membrane interaction dynamics of Mycobacterium tuberculosis fatty Acyl-CoA synthetase FadD13", Biochemistry (2021), DOI: 10.1021/acs.biochem.0c00987
- Lucia Silvestrini, Norhan Belhaj, Lucia Comez, Yuri Gerelli, Antonino Lauria, Valeria Libera, Paolo Mariani, Paola Marzullo, Maria Grazia Ortore, Antonio Palumbo Piccionello, Caterina Petrillo, Lucrezia Savini, Alessandro Paciaroni, Francesco Spinozzi, "The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors", Scientific Reports, 11 (2021), DOI: 10.1038/s41598-021-88630-9
- Tiziano Ongaro, Salvatore R. Guarino, Luigi Scietti, Martina Palamini, Sarah Wulhfard, Dario Neri, Alessandra Villa, Federico Forneris, "Inference of molecular structure for characterization and improvement of clinical grade immunocytokines", Journal Of Structural Biology, 213 (2021), DOI: 10.1016/j.jsb.2021.107696
- Marta Compte, Seandean L. Harwood, Ainhoa Erce-Llamazares, Antonio Tapia-Galisteo, Eduardo Romero, Irene Ferrer, Eva M Garrido-Martin, Ana B. Enguita, Maria C Ochoa, Belen Blanco, Marta Oteo, Nekane Merino, Daniel Nehme-Alvarez, Oana Hangiu, Carmen Domínguez-Alonso, Manuela Zonca, Angel Ramírez-Fernández, Francisco J. Blanco, Miguel Angel Morcillo, Ines G. Munoz, Ignacio Melero, José L. Rodríguez-Peralto, Luis G. Paz-Ares, Laura Sanz, Luis Álvarez-Vallina, "An Fc-free EGFR-specific 4-1BB-agonistic trimerbody displays broad anti-tumor activity in humanized murine cancer models without toxicity", Clinical Cancer Research (2021), DOI: 10.1158/1078-0432.CCR-20-4625
- Marco Salamina, Bailey C. Montefiore, Mengxi Liu, Daniel J. Wood, Richard Heath, James R. Ault, Lan-Zhen Wang, Svitlana Korolchuk, Arnaud Basle, Martyna Pastok, Judith Reeks, Natalie J. Tatum, Frank Sobott, Stefan T. Arold, Michele Pagano, Martin E. M. Noble, Jane A. Endicott, "Discriminative SKP2 interactions with CDK-cyclin complexes support a cyclin a-specific role in p27KIP1 degradation", Journal Of Molecular Biology, 433 (2021), DOI: 10.1016/j.jmb.2020.166795
- Vanessa Meier-Stephenson, Maulik D. Badmalia, Tyler Mrozowich, Keith C. K. Lau, Sarah K. Schultz, Darren L. Gemmill, Carla Osiowy, Guido Van Marle, Carla S. Coffin, Trushar R. Patel, "Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA", Journal Of Biological Chemistry, 61 (2021), DOI: 10.1016/j.jbc.2021.100589
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- Corey R. Nelson, Tyler Mrozowich, Sean M. Park, Simmone D’souza, Amy Henrickson, Justin R. J. Vigar, Hans-Joachim Wieden, Raymond J. Owens, Borries Demeler, Trushar R. Patel, "Human DDX17 unwinds rift valley fever virus non-coding RNAs", International Journal Of Molecular Sciences, 22 (2021), DOI: 10.3390/ijms22010054
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