Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy B21 Contact
Beamline phone numbers:
+44 (0) 1235 77 8627
+44 (0) 1235 77 8640
Principal Beamline Scientist:
Nathan Cowieson
Tel: +44 (0) 1235 567 504
E-mail: [email protected]
Science Group Leader
Robert Rambo
Email: [email protected]
Tel: +44 (0)1235 56 7675
B21 High Throughput SAXS
Status: Operational
Beamsize: <75 μm
Detector: Eiger 4M
Energy: 6 - 23 keV
Detector: Eiger 4M
Energy: 6 - 23 keV
36 items found for 2016 [total: 654]
Structural basis for regulation and specificity of fructooligosaccharide import in Streptococcus pneumoniae Structure, Dec 2016 DOI: 10.1016/j.str.2016.11.008
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Functional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome Scientific Reports, 6 Dec 2016 DOI: 10.1038/srep38031
Structural mechanism for cargo recognition by the retromer complex Cell, 167 Dec 2016 DOI: 10.1016/j.cell.2016.10.056
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography
A study into the self-assembly of bioactive peptide amphiphiles Nov 2016
Thesis B21-High Throughput SAXS
The biophysical characterisation and SAXS analysis of human NLRP1 uncover a new level of complexity of NLR proteins Plos One, 11 Oct 2016 DOI: 10.1371/journal.pone.0164662
Independent multimerization of Latent TGFβ Binding Protein-1 stabilized by cross-linking and enhanced by heparan sulfate Scientific Reports, 6 Sept 2016 DOI: 10.1038/srep34347
Subunit arrangement in GpsB, a regulator of cell wall biosynthesis Microbial Drug Resistance, 22 Sept 2016 DOI: 10.1089/mdr.2016.0050
CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex Febs Letters, Sept 2016 DOI: 10.1002/1873-3468.12362
A de novo virus-like topology for synthetic virions Journal Of The American Chemical Society, Sept 2016 DOI: 10.1021/jacs.6b05751
Proteins involved in sleep homeostasis: biophysical characterization of INC and its partners Biochimie, Sept 2016 DOI: 10.1016/j.biochi.2016.09.013
Journal Paper B21-High Throughput SAXS
Mesoporous self-assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-insoluble substances Soft Matter, 12 Aug 2016 DOI: 10.1039/C6SM00661B
TssA forms a gp6‐like ring attached to the type VI secretion sheath The Embo Journal, 35 Aug 2016 DOI: 10.15252/embj.201694024
UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome Cell, 166 Aug 2016 DOI: 10.1016/j.cell.2016.07.001
Mammalian tolloid proteinases: role in growth factor signalling Febs Letters, 590 Aug 2016 DOI: 10.1002/1873-3468.12287
Studying the flexibility of the RNA-dependent RNA polymerase of influenza virus Aug 2016
Diamond Annual Review Highlight B21-High Throughput SAXS I03-Macromolecular Crystallography I04-Macromolecular Crystallography
Structural basis of Smoothened regulation by its extracellular domains Nature, 535 Jul 2016 DOI: 10.1038/nature18934
Structural basis of host Autophagy-related protein 8 (ATG8) binding by the Irish potato famine pathogen effector protein PexRD54 Journal Of Biological Chemistry, Jul 2016 DOI: 10.1074/jbc.M116.744995
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I04-Macromolecular Crystallography open access
Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic Nature Communications, 7 Jul 2016 DOI: 10.1038/ncomms12294
Structural and biophysical analysis of nuclease protein antibiotics Biochemical Journal, Jul 2016 DOI: 10.1042/BCJ20160544
Understanding chromatin regulators Jul 2016
Science Highlight B21-High Throughput SAXS I24-Microfocus Macromolecular Crystallography
Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases Rsc Advances, 6 June 2016 DOI: 10.1039/C6RA05499D
Structure of the Dcp2–Dcp1 mRNA-decapping complex in the activated conformation Nature Structural & Molecular Biology, 23 May 2016 DOI: 10.1038/nsmb.3232
Journal Paper B21-High Throughput SAXS
Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development Open Biology, 6 May 2016 DOI: 10.1098/rsob.160053
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural analysis of human KDM5B guides histone demethylase inhibitor development Nature Chemical Biology, May 2016 DOI: 10.1038/nchembio.2087
Journal Paper B21-High Throughput SAXS I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity The Embo Journal, 35 May 2016 DOI: 10.15252/embj.201593741
Modification of β-sheet forming peptide hydrophobic face: effect on self-assembly and gelation Langmuir, Apr 2016 DOI: 10.1021/acs.langmuir.5b03841
Self-assembly of the cyclic lipopeptide daptomycin: spherical micelle formation does not depend on the presence of calcium chloride Chemphyschem, Apr 2016 DOI: 10.1002/cphc.201600308
Journal Paper B21-High Throughput SAXS
Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain Scientific Reports, 6 Apr 2016 DOI: 10.1038/srep23748
Structure of Gremlin-1 and analysis of its interaction with BMP-2 Biochemical Journal, Apr 2016 DOI: 10.1042/BCJ20160254
The dynamic organization of fungal acetyl-CoA carboxylase Nature Communications, 7 Apr 2016 DOI: 10.1038/ncomms11196
Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level Elife, 5 Mar 2016 DOI: 10.7554/eLife.13909
The structure of the core NuRD repression complex provides insights into its interaction with chromatin Elife, Mar 2016 DOI: 10.7554/eLife.13941
Ca-dependent folding of human calumenin Plos One, 11 Mar 2016 DOI: 10.1371/journal.pone.0151547
Journal Paper B21-High Throughput SAXS B23-Circular Dichroism I22-Small angle scattering & Diffraction open access
Self-assembly of the toll-like receptor agonist macrophage-activating lipopeptide MALP-2 and of its constituent peptide Biomacromolecules, 17 (2) Feb 2016 DOI: 10.1021/acs.biomac.5b01573
Structures of two melanoma-associated antigens suggest allosteric regulation of effector binding Plos One, 11 Feb 2016 DOI: 10.1371/journal.pone.0148762
Journal Paper B21-High Throughput SAXS I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
A self-assembling fluorescent dipeptide conjugate for cell labelling Colloids And Surfaces B: Biointerfaces, 137 Jan 2016 DOI: 10.1016/j.colsurfb.2015.04.062
- Simone Culurgioni, Gemma Harris, Anirudh K. Singh, Samantha J. King, Martin A. Walsh, "Structural basis for regulation and specificity of fructooligosaccharide import in Streptococcus pneumoniae", Structure (2016), DOI: 10.1016/j.str.2016.11.008
- Muhamamd Faheem, Diogo Martins-De-Sa, Julia F. D. Vidal, Alice C. M. Álvares, Jose Brandao-Neto, Louise E. Bird, Mark D. Tully, Frank Von Delft, Betulia M. Souto, Betania F. Quirino, Sonia M. Freitas, João Alexandre R. G. Barbosa, "Functional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome", Scientific Reports, 6 (2016), DOI: 10.1038/srep38031
- María Lucas, David c. Gershlick, Ander Vidaurrazaga, Adriana Rojas, Juan s. Bonifacino, Aitor Hierro, "Structural mechanism for cargo recognition by the retromer complex", Cell, 167, 1623 - 1635.e14 (2016), DOI: 10.1016/j.cell.2016.10.056
- [Thesis] S. Kirkham, "A study into the self-assembly of bioactive peptide amphiphiles" (2016)
- Luigi Martino, Louise Holland, Evangelos Christodoulou, Simone Kunzelmann, Diego Esposito, Katrin Rittinger, "The biophysical characterisation and SAXS analysis of human NLRP1 uncover a new level of complexity of NLR proteins", Plos One, 11 (2016), DOI: 10.1371/journal.pone.0164662
- Helen Troilo, Ruth Steer, Richard F. Collins, Cay M. Kielty, Clair Baldock, "Independent multimerization of Latent TGFβ Binding Protein-1 stabilized by cross-linking and enhanced by heparan sulfate", Scientific Reports, 6 (2016), DOI: 10.1038/srep34347
- Robert M. Cleverley, Jeanine Rismondo, Michael P. Lockhart-Cairns, Paulien T. Van Bentum, Alexander J. F. Egan, Waldemar Vollmer, Sven Halbedel, Clair Baldock, Eefjan Breukink, Richard J. Lewis, "Subunit arrangement in GpsB, a regulator of cell wall biosynthesis", Microbial Drug Resistance, 22, 446 - 460 (2016), DOI: 10.1089/mdr.2016.0050
- Tiankun Zhou, Jennifer R. Fleming, Barbara Franke, Julijus Bogomolovas, Igor Barsukov, Daniel J. Rigden, Siegfried Labeit, Olga Mayans, "CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex", Febs Letters (2016), DOI: 10.1002/1873-3468.12362
- James Noble, Emiliana De Santis, Jascindra Ravi, Baptiste Lamarre, Valeria Castelletto, Judith Mantell, Santanu Ray, Maxim G. Ryadnov, "A de novo virus-like topology for synthetic virions", Journal Of The American Chemical Society (2016), DOI: 10.1021/jacs.6b05751
- Luciano Pirone, Giovanni Smaldone, Carla Esposito, Nicole Balasco, Maxim V. Petoukhov, Alessandro Spilotros, Dmitri I. Svergun, Sonia Di Gaetano, Luigi Vitagliano, Emilia Maria Pedone, "Proteins involved in sleep homeostasis: biophysical characterization of INC and its partners", Biochimie (2016), DOI: 10.1016/j.biochi.2016.09.013
- Leïla Zerkoune, Sylviane Lesieur, Jean-Luc Putaux, Luc Choisnard, Annabelle Gèze, Denis Wouessidjewe, Borislav Angelov, Corinne Vebert-Nardin, James Doutch, Angelina Angelova, "Mesoporous self-assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-insoluble substances", Soft Matter, 12, 7539 - 7550 (2016), DOI: 10.1039/C6SM00661B
- Sara Planamente, Osman Salih, Eleni Manoli, David Albesa-Jove, Paul Freemont, Alain Filloux, "TssA forms a gp6‐like ring attached to the type VI secretion sheath", The Embo Journal, 35, 1613 - 1627 (2016), DOI: 10.15252/embj.201694024
- Roland Hjerpe, John s. Bett, Matthew J. Keuss, Alexandra Solovyova, Thomas G. Mcwilliams, Clare Johnson, Indrajit Sahu, Joby Varghese, Nicola Wood, Melanie Wightman, Georgina Osborne, Gillian P. Bates, Michael h. Glickman, Matthias Trost, Axel Knebel, Francesco Marchesi, Thimo Kurz, "UBQLN2 mediates autophagy-independent protein aggregate clearance by the proteasome", Cell, 166, 935 - 949 (2016), DOI: 10.1016/j.cell.2016.07.001
- Helen Troilo, Christopher P. Bayley, Anne L. Barrett, Michael P. Lockhart-Cairns, Thomas A. Jowitt, Clair Baldock, "Mammalian tolloid proteinases: role in growth factor signalling", Febs Letters, 590, 2398 - 2407 (2016), DOI: 10.1002/1873-3468.12287
- [Diamond Annual Review Highlight] Diamond Light Source, "Studying the flexibility of the RNA-dependent RNA polymerase of influenza virus" (2016)
- Eamon F. X. Byrne, Ria Sircar, Paul S. Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D. Tully, Laurel Mydock-Mcgrane, Douglas F. Covey, Robert P. Rambo, Mark S. P. Sansom, Simon Newstead, Rajat Rohatgi, Christian Siebold, "Structural basis of Smoothened regulation by its extracellular domains", Nature, 535, 517 - 522 (2016), DOI: 10.1038/nature18934
- Abbas Maqbool, Richard Hughes, Yasin F Dagdas, Nicholas Tregidgo, Erin Zess, Khaoula Belhaj, Adam Round, Tolga O Bozkurt, Sophien Kamoun, Mark Banfield, "Structural basis of host Autophagy-related protein 8 (ATG8) binding by the Irish potato famine pathogen effector protein PexRD54", Journal Of Biological Chemistry (2016), DOI: 10.1074/jbc.M116.744995
- Chenguang Lou, Manuel C. Martos-Maldonado, Charlotte S. Madsen, Rasmus P. Thomsen, Soren Roi Midtgaard, Niels Johan Christensen, Jørgen Kjems, Peter W. Thulstrup, Jesper Wengel, Knud J. Jensen, "Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic", Nature Communications, 7 (2016), DOI: 10.1038/ncomms12294
- Alexander Klein, Justyna Wojdyla, Amar Joshi, Inokentijs Josts, L. C. Mccaughey, N. Housden, R. Kaminska, Olwyn Byron, D. Walker, C. Kleanthous, "Structural and biophysical analysis of nuclease protein antibiotics", Biochemical Journal (2016), DOI: 10.1042/BCJ20160544
- [Science Highlight] Diamond Light Source, "Understanding chromatin regulators" (2016)
- Julian E. Fuchs, Inés G. Muñoz, David Timson, Angel L. Pey, "Experimental and computational evidence on conformational fluctuations as a source of catalytic defects in genetic diseases", Rsc Advances, 6, 58604 - 58612 (2016), DOI: 10.1039/C6RA05499D
- Eugene Valkov, Sowndarya Muthukumar, Chung-Te Chang, Stefanie Jonas, Oliver Weichenrieder, Elisa Izaurralde, "Structure of the Dcp2–Dcp1 mRNA-decapping complex in the activated conformation", Nature Structural & Molecular Biology, 23, 574 - 579 (2016), DOI: 10.1038/nsmb.3232
- Tao Ni, Karl Harlos, Robert J. C. Gilbert, "Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development", Open Biology, 6 (2016), DOI: 10.1098/rsob.160053
- Catrine Johansson, Velupillai Srikannathasan, Anthony Tumber, Aleksandra Szykowska, Edward S. Hookway, Radoslaw Nowak, Claire Strain-Damerell, Carina Gileadi, Martin Philpott, Nicola Burgess-Brown, Na Wu, Jolanta Kopec, Andrea Nuzzi, Holger Steuber, Ursula Egner, Volker Badock, Shonagh Munro, Nicholas B Lathangue, Sue Westaway, Jack Brown, Nick Athanasou, Rab Prinjha, Paul E Brennan, Udo Oppermann, "Structural analysis of human KDM5B guides histone demethylase inhibitor development", Nature Chemical Biology (2016), DOI: 10.1038/nchembio.2087
- Marios Koliopoulos, Diego Esposito, Evangelos Christodoulou, Ian Taylor, Katrin Rittinger, "Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity", The Embo Journal, 35, 1204 - 1218 (2016), DOI: 10.15252/embj.201593741
- Mohamed Elsawy, Andrew M. Smith, Nigel Hodson, Adam Squires, Aline Fiona Miller, Alberto Saiani, "Modification of β-sheet forming peptide hydrophobic face: effect on self-assembly and gelation", Langmuir (2016), DOI: 10.1021/acs.langmuir.5b03841
- Steven Kirkham, Valeria Castelletto, Ian W. Hamley, Katsuaki Inoue, Robert Rambo, Mehedi Reza, Janne Ruokolainen, "Self-assembly of the cyclic lipopeptide daptomycin: spherical micelle formation does not depend on the presence of calcium chloride", Chemphyschem (2016), DOI: 10.1002/cphc.201600308
- Dipali Patel, Jolanta Kopec, Fiona Fitzpatrick, Thomas Mccorvie, Wyatt Yue, "Structural basis for ligand-dependent dimerization of phenylalanine hydroxylase regulatory domain", Scientific Reports, 6 (2016), DOI: 10.1038/srep23748
- Migle Kisonaite, Xuelu Wang, Marko Hyvonen, "Structure of Gremlin-1 and analysis of its interaction with BMP-2", Biochemical Journal (2016), DOI: 10.1042/BCJ20160254
- Moritz Hunkeler, Edward Stuttfeld, Anna Hagmann, Stefan Imseng, Timm Maier, "The dynamic organization of fungal acetyl-CoA carboxylase", Nature Communications, 7 (2016), DOI: 10.1038/ncomms11196
- Daniel Coutandin, Christian Osterburg, Ratnesh Kumar Srivastav, Manuela Sumyk, Sebastian Kehrloesser, Jakob Gebel, Marcel Tuppi, Jens Hannewald, Birgit Schäfer, Eidarus Salah, Sebastian Mathea, Uta Müller-Kuller, James Doutch, Manuel Grez, Stefan Knapp, Volker Dötsch, "Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level", Elife, 5 (2016), DOI: 10.7554/eLife.13909
- Christopher Millard, Nirajan Varma, Almutasem Saleh, Kyle Morris, Peter Watson, Andrew Bottrill, Louise Fairall, Corinne Smith, John Schwabe, "The structure of the core NuRD repression complex provides insights into its interaction with chromatin", Elife (2016), DOI: 10.7554/eLife.13941
- Marco Mazzorana, Rohanah Hussain, Thomas Sorensen, "Ca-dependent folding of human calumenin", Plos One, 11 (2016), DOI: 10.1371/journal.pone.0151547
- Valeria Castelletto, Steven Kirkham, Ian W. Hamley, Radoslaw Kowalczyk, Martin Rabe, Mehedi Reza, Janne Ruokolainen, "Self-assembly of the toll-like receptor agonist macrophage-activating lipopeptide MALP-2 and of its constituent peptide", Biomacromolecules, 17 (2), 631 - 640 (2016), DOI: 10.1021/acs.biomac.5b01573
- Joseph A Newman, Christopher Cooper, Annette Roos, Hazel Aitkenhead, Udo C. T. Oppermann, Hearn J. Cho, Roman Osman, Opher Gileadi, Hiroshi Shiku, "Structures of two melanoma-associated antigens suggest allosteric regulation of effector binding", Plos One, 11 (2016), DOI: 10.1371/journal.pone.0148762
- Steven Kirkham, Ian W. Hamley, Andrew M. Smith, Ricardo M. Gouveia, Che J. Connon, Mehedi Reza, Janne Ruokolainen, "A self-assembling fluorescent dipeptide conjugate for cell labelling", Colloids And Surfaces B: Biointerfaces, 137, 104 - 108 (2016), DOI: 10.1016/j.colsurfb.2015.04.062
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
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