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The cryo-CLEM is a dedicated cryo-fluorescence microscope, designed to maintain cryo-conditions for specimen handling. It provides high resolution imaging to enable the user to target the regions of interest for the correlative process.
The Correlative Light and Electron Microscopy (CLEM) process includes the extra information provided by the fluorescence signal and guides the cryo-EM tilt series collection, making the data acquisition much more accurate and efficient.
cryo-CLEM is designed and optimised for the cryo-correlation workflow. It features a specially designed cryo-stage that goes with the optical microscope, an easy-to-use grid transfer system, as well as a special software that is easy to use.
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