Diamond-II Webinar: Large volume biological 3D X-ray nanoImaging

Nov 10. till Nov 10.

Diamond-II Webinar: Large volume biological 3D X-ray nanoImaging

This webinar is an excellent opportunity to gain insight into the advances being made to exploit X-rays for large volume nanoscale imaging of biological samples. The webinar will provide an overview of Diamond’s imaging capabilities and the new opportunities for biological imaging presented by Diamond-II, a co-ordinated programme of development that includes a major machine upgrade to a low emittance storage ring at higher energy, as well as a portfolio of new and rebuilt beamlines and enhancements to existing ones.

The increased coherence and brightness made available by Diamond-II will open the way to high-throughput nano-imaging of large volume biological samples. As part of the Diamond-II programme, two flagship proposals have been proposed to provide state-of-the-art facilities for hard x-ray ptychography and x-ray holography through major upgrades to the I13 beamline and a dedicated new beamline for 3D biological imaging.

In this webinar, invited speaker Dr. Alexandra Pacureanu from ESRF will summarise her recent work on the application of x-ray holographic nanotomography and x-ray fluorescence imaging for 3D imaging of tissues and cells to provide a flavour of the current and future landscape enabled by synchrotron sources.

Please find the full agenda, link to register and proposal background below.

Date
10/11/20202020-11-10T14:00:00 - 10/11/20202020-11-10T15:00:00
Time
14:00 - 15:00
Location
Online via Zoom
Link
Register here

Click here to download the Diamond-II Bio-Imaging Overview Document

Proposal Background

Diamond has progressively strengthened its bioimaging capabilities since the first tranche of MX beamlines in 2007 came on-line allowing protein structures and large macromolecular complexes and viruses to be imaged at sub-nm resolutions. The portfolio now consists of a range of techniques that allows imaging across a range of resolution and length scales through dedicated beamlines for infrared imaging (B22),CD imaging (B23), BioSAXS (B21),a cryo soft x-ray transmission microscope (B24), a soft X-ray scanning microscope (I08) and hard X-ray imaging beamlines (I13, I14). In the last five years these synchrotron radiation-based beamlines have complemented Diamond’s centre for electron bio-imaging, eBIC, which provides an exceptional user programme in cryo-electron microscopy and tomography.

The proposed flagship beamline aims to extend these capabilities by providing the means to image thick/large volume biological samples at 20 nm resolution for sub mm specimens while allowing specimen sizes up to a cm at somewhat lower resolution.

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Keep informed

If you are interested in keeping up to date on the Nanoscale BioImaging Working Group progress and would like to receive updates by email, please sign up to our BioImaging Flagship Interest Group by clicking the button below:

I'd like to keep informed

You are also welcome to contact the BioImaging group leader Martin Walsh or user working group chair and project champion Andreas Schaefer (Francis Crick Institute) with any questions or feedback.

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Webinar Agenda - please note the following timings are GMT (UK time zone):        

14:00-14:05 | Introduction to the Diamond-II project - Martin Walsh (Diamond Light Source)

14:05-14:10 | Scientific Opportunities for BioImaging enabled by Diamond-II - Andreas Schaefer (Francis Crick Institute)

14:10-14:45 | Webinar lecture: “X-ray holographic nanotomography and X-ray fluorescence imaging for 3D exploration of tissues and cells” - Alexandra Pacureanu (European Synchrotron Radiation Facility, ESRF)

14:45-15:00 | Q&A

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Background

Find out more about the Diamond-II programme here, and download the Diamond-II | Advancing Science science case here.

This webinar forms part of the second stage of user engagement for the flagship proposals put forward by Diamond’s imaging groups. In 2018, an introductory workshop was held for users to discuss the project's potential benefits for research and to help further develop the science case and direction for the machine upgrade. You can revisit the event page here

The business case for flagship beamline projects was presented to the Diamond Science Advisory Committee (SAC) and Diamond Industrial Science Committee (DISCo) in May, who recommended that a full business case should be put together for each new beamline or upgrade proposal. The Diamond team for each proposal has formed its own User Working Group with representatives from the User Community, who will build the finalised business cases, to be put forward to SAC/DISCo for consideration and prioritisation in December 2020.

User engagement and input is therefore vital for this proposal to build the strongest case possible and ensure key capabilities are captured.

Contact us

If you have any questions about this webinar, please email the Diamond Events Team.

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