Principal Beamline Scientist:
Frank von Delft
Tel: +44 (0) 1235 778997
E-mail: [email protected]
Senior Beamline Scientist:
Daren Fearon
Tel: +44 (0) 1235 778936
E-mail: [email protected]
Email: [email protected]
Tel: +44 (0) 1235 778926
This library was designed by the Nelson and Marsden groups (University of Leeds) to allow the efficient exploration of chemical space. Fragments in this library have the following features:
These fragments were prepared by a concise 'top down' synthetic approach (see references below) and have proven to be productive in the identification of distinctive hits at Diamond.
Compounds:
SMILES: click to download the Leeds 3D SMILES
For follow-ups, please contact: N/A
PUBLICATION to cite:
"Realisation of small molecule libraries based on frameworks distantly related to natural products" A. Aimon, G. Karageorgis, J. Masters, M. Dow, P. G. E. Craven, M. Ohsten, A. Willaume, R. Morgentin, N. R. -L., H. Lemoine, T. Kalliokoski, A. J. Eatherton, D. J. Foley, S. P. Marsden and A. Nelson, Org. Biomol. Chem. 2018, 16, 3160-3167 (link)
"Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks" D. J. Foley, P. G. E. Craven, P. M. Collins, R. G. Doveston, A. Aimon, R. Talon, I. Churcher, F. von Delft, S. P. Marsden, A. Nelson, Chem. Eur. J. 2017, 23, 15227-15232 (pdf)
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