Cambridge 3D (Live)

This library is a DOS (Diversity Oriented Synthesis) library designed by the Spring group in the University of Cambridge. It relies on two main ideas:

• 3D character. Unlike many libraries containing fragments with a high sp2 (flat) character resulting from simple, robust reactions heavily used in the pharmaceutical industry, the design of this library was based on easily accessible scaffolds with high sp3 character.
• Versatility. From any of these fragments hits it is possible to quickly synthesise many follow-up compounds exploring any of the desired vectors, starting from the main scaffold and using a set of reaction that has been already chemically validated.

We are keen for anyone to use this library. For more information or to contact us, see https://www-spring.ch.cam.ac.uk/research/sgcc.shtml

Compounds:

• 137 fragments
• 250-500 mM in d6-DMSO

SMILES: click to download the Cambridge 3D plate map.

For follow-ups, please contact: David Spring

PUBLICATION to cite:

S. L. Kidd et al., Demonstration of the utility of DOS-derived fragement libraries for rapid hit derivatisation in a multidirectional fashion, Chem. Sci. 2020, Edge Article. DOI

ACKNOWLEDGEMENT text to use: 

The Cambridge 3D library was designed and synthesised by the Spring group in the University of Cambridge and funded by EPSRC.