Principal Beamline Scientist:
Frank von Delft
Tel: +44 (0) 1235 778997
E-mail: [email protected]
Senior Beamline Scientist:
Daren Fearon
Tel: +44 (0) 1235 778936
E-mail: [email protected]
Email: [email protected]
Tel: +44 (0) 1235 778926
The EU-OPENSCREEN fragment library, designed by the EU-OPENSCREEN partner sites Fraunhofer IME in Hamburg and IMIM in Barcelona, in collaboration with iNEXT-Discovery/ Instruct-ERIC partners, is composed of 968 low-molecular-weight fragments and 88 ultra-low-molecular-weight compounds (so called minifrags). Deriving from the fragment space of the EU-OPENSCREEN small molecule diversity library (100k commercial compounds),[1] this designed set of compounds facilitates the hit follow-up with a rapid availability of parent molecules from the EU-OPENSCREN small molecule collection, of which the fragments and minifrags are substructures. A broader description is contained in J. Mestres et al. (paper in preparation).
This library was funded by the EU H2020 project EU-OPENSCREEN-DRIVE (grant agreement No 823893).
Prior to usage of this library, please fill in the user application for each project for tracking purposes.
Compounds:
SMILES: click to download the EU-OPENSCREEN plate map.
For follow-ups, please check: EU-OPENSCREEN Medicinal chemistry service
PUBLICATION to cite:
D. Horvath, M. Lisurek, B. Rupp, R. Kühne, E. Specker, J. von Kries, D. Rognan, C. D. Andersson, F. Almqvist, M. Elofsson, et al., ChemMedChem 2014, 9, 2309–2326.
ACKNOWLEDGEMENT text to use:
The user/ external user acknowledges EU-OPENSCREEN ERIC for providing its fragment library for the presented scientific work. EU-OPENSCREEN ERIC has received funding from European Union´s Horizon 2020 research and innovation programme under grant agreement No 823893 (EU-OPENSCREEN-DRIVE).
Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.
Copyright © 2022 Diamond Light Source
Diamond Light Source Ltd
Diamond House
Harwell Science & Innovation Campus
Didcot
Oxfordshire
OX11 0DE
Diamond Light Source® and the Diamond logo are registered trademarks of Diamond Light Source Ltd
Registered in England and Wales at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom. Company number: 4375679. VAT number: 287 461 957. Economic Operators Registration and Identification (EORI) number: GB287461957003.