EU-OPENSCREEN Library (Live)

The EU-OPENSCREEN fragment library, designed by the EU-OPENSCREEN partner sites Fraunhofer IME in Hamburg and IMIM in Barcelona, in collaboration with iNEXT-Discovery/ Instruct-ERIC partners, is composed of 968 low-molecular-weight fragments and 88 ultra-low-molecular-weight compounds (so called minifrags). Deriving from the fragment space of the EU-OPENSCREEN small molecule diversity library (100k commercial compounds),^[1] this designed set of compounds facilitates the hit follow-up with a rapid availability of parent molecules from the EU-OPENSCREN small molecule collection, of which the fragments and minifrags are substructures. A broader description is contained in J. Mestres et al. (paper in preparation).

This library was funded by the EU H2020 project EU-OPENSCREEN-DRIVE (grant agreement No 823893).

Prior to usage of this library, please fill in the user application for each project for tracking purposes.

Compounds:

• 968 fragments: 100 mM in DMSO-d₆
• 1536 ECHO-compatible plate

SMILES: click to download the EU-OPENSCREEN plate map.

For follow-ups, please check: EU-OPENSCREEN Medicinal chemistry service

PUBLICATION to cite:

D. Horvath, M. Lisurek, B. Rupp, R. Kühne, E. Specker, J. von Kries, D. Rognan, C. D. Andersson, F. Almqvist, M. Elofsson, et al., ChemMedChem 2014, 9, 2309–2326.

ACKNOWLEDGEMENT text to use:

The user/ external user acknowledges EU-OPENSCREEN ERIC for providing its fragment library for the presented scientific work. EU-OPENSCREEN ERIC has received funding from European Union´s Horizon 2020 research and innovation programme under grant agreement No 823893 (EU-OPENSCREEN-DRIVE).