Fragment-based screening is now well-established as a powerful approach to early drug ("lead") discovery.
Currently, we are operating with no users on-site i.e. Mail-in of protein and crystallisation solutions or crystallisation plates only. However, Diamond is progressively ramping up its activity with users on-site.
How will this experiment be affected by the Covid-19 arrangements at Diamond?
Consider what you can reasonably achieve with only 2 users allowed at any one time and apply for the amount of beamtime you would need to achieve your goals within these constraints - even if this would require some beamtime to go unused (this is against normal Diamond conditions of use).
For academic access, calls for proposals are issued twice a year (details here) and applications are made via the User Administration System (UAS).
Like all Diamond access, proposals are reviewed competitively by independent peer review (panel 11); our current capacity is 30-40 screens per year, though likely to increase.
For any questions, contact Frank von Delft, the I04-1/XChem Principal Beamlines Scientist.
For proprietary access, contact Alex Dias from the Industrial Liaison Office.
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