Martin Walsh

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Martin Walsh is Deputy Director of Life Sciences at Diamond. Martin is also a Research Group Leader at the Research Complex at Harwell (RCaH). He joined Diamond in January 2009 from the MRC, France

Email: martin.walsh@diamond.ac.uk
Tel: +44 (0) 1235 778518

Techniques and Disciplines

Other Specialist Areas

  • Bacterial Respiratory Pathogens
  • High-throughput methodologies for Macromolecular Crystallography
  • Cryo-Electron microscopy.

Latest Publications

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Research Expertise

We are a structural biology group based at Diamond light source which presents us with an arsenal of state-of-the-art techniques to determine the structures of macromolecules. We have used primarily X-ray crystallography in the past, but now combine this with biological small angle scattering (BIOSAXS) and cryo-electron microscopy techniques. We complement our structural studies with a range of biochemical and spectroscopic techniques to fully understand the function and the dynamics of the systems under study.
During the COVID19 pandemic our activities were  fully diverted to applying a structure based drug discovery approach to the two cysteine proteases of SARS-CoV-2. We took a completely open-access approach to this work which led to the Covid Moonshoot initiative. A full summary along with experimental data can be found here. We continue to actively work on development of antivirals against coronavirus and emerging viral pathogens of concern through our participation in the ASAP Discovery Consortium which is a NIH Antiviral Drug Discovery (AViDD) U19 Center.

Bacterial pathogenesis

The main topic of research in the group is using a targeted structural and functional approach to understanding at the molecular level how bacteria cause disease. We have focused our efforts in the main part on respiratory bacterial pathogens that continue to pose a significant health risk to the very young and elderly and have identified a number of vital processes within these pathogens to characterize and assess as targets for drug discovery. Our interests lie predominately in understanding regulation of bacterial biofilms, the structural basis of bacterial adherence and antimicrobial resistance mechanisms.

 

 

 

 

 

 

 

Collaborations

University of Southampton
Prof Jeremy Webb and
Dr. Ivo Tew

University of Southampton

University of Oxford
Prof Chris Schofield

University of Oxford

Nationwide Childrens Hospital
Ohio USA

Dr. Sam King

Nationwide Children's Hospital

Quadram Institute
Prof Nathalie Juge

Quadram Institute

 

University of Reading
Prof Patrick Lewis
(now at Royal Veterinary College,
University of London )
and Eva Kevei  

University of Reading

 

University of St. Andrews
Dr. Tracey Gloster

University of Saint Andrew's

 

 

Biography

After graduating from University College Galway (UCG) with a first class Honours degree in Chemistry in 1989, Walsh remained at UCG for his PhD work which used X-ray crystallography to fully characterize the flavoprotein, flavodoxin. This work aided in providing a general model for how flavoproteins modulate the redox potentials of flavin mononucleotide (FMN). The work was a significant milestone for structural biology in Ireland, as it presented the first protein crystal structures determined from an Irish-based research group.

Early postdoctoral work at York and EMBL Hamburg concentrated on the development and determination of protein structures at atomic resolution which was being pioneered at that time in Hamburg. This work contributed to introducing routine refinement of structures at this resolution as well as providing experimental data on the stereochemistry of amino acids in proteins.
 
In 1997 Walsh moved to Argonne National Laboratory (ANL) where he worked primarily on chaperonins and contributed to the commissioning of the world’s first dedicated insertion device beamline for exploiting anomalous diffraction in macromolecular crystallography: ID19 at the Advance Photon Source (APS). Work and associated research carried out at Argonne in the late 1990’s contributed strongly to establishing the MAD technique. In 1999 he moved to IRBM in Rome where work focused on the structural biology of the hepatitis C virus.
 
In 2001 he was appointed MRC group leader for BM14, based at the ESRF. Key hardware and software solutions to crystallography were delivered – automation of sample handling through robotics and management of crystallographic data (ISPyB) which have changed the way crystallographers now approach macromolecular structure determination at synchrotron beamlines.
 
In 2009, he joined Diamond Light Source with responsibility for life science research.

Diamond Light Source

Diamond Light Source is the UK's national synchrotron science facility, located at the Harwell Science and Innovation Campus in Oxfordshire.

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