David Owen


David is an Electron Microscope Scientist at eBIC and a visiting scientist in the Walsh Research group.

Email: [email protected]
Tel: +44 (0) 1235 56 7521

Following completion of his Ph.D. in 2015 (University of St Andrews, Scotland), David joined Martin Walsh's macromolecular crystallography group at Diamond Light Source as a Post-Doctoral Research Associate. David's focus was structural characterisation of proteins involved in carbohydrate processing, by pathogenic and commensal bacteria, with a particular interest in sialic acid. Work on membrane-bound carbohydrate transporters led to greater use of single particle electron microscopy. David also contributed to Diamond's effort to unearth new drugs to combat COVID-19 by solving the structure of the SARS-CoV-2 main protease and papain like proteases in complex with numerous molecules of therapeutic interest.

David joined the electron Bio-Imaging Centre in August 2020 as an Electron Microscope Scientist. His research interests in carbohydrate processing remains, and his hope is to use the tools and techniques present at eBIC to continue to answer exciting biological questions.



June 2022 - xia2.multiplex : a multi-crystal data-analysis pipeline, Acta Crystallographica Section D Structural Biology10.1107/S2059798322004399

May 2022 - Penicillin derivatives inhibit the SARS-COV-2 main protease by reaction with its nucleophilic cysteine, Journal Of Medicinal Chemistry10.1021/acs.jmedchem.1c02214

December 2021 - The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract, Plos Biology10.1371/journal.pbio.3001498

October 2021 - Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding, Chemical Science10.1039/D1SC03628A

October 2021 - The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif, Plos One10.1371/journal.pone.0256070

June 2021 - An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor, Cell Chemical Biology10.1016/j.chembiol.2021.05.018

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