Principal Beamline Scientist:
Frank von Delft
Tel: +44 (0) 1235 778997
E-mail: [email protected]
Senior Beamline Scientist:
Daren Fearon
Tel: +44 (0) 1235 778936
E-mail: [email protected]
Email: [email protected]
Tel: +44 (0) 1235 778926
The PepLites is a small library of halogenated peptidomimetics that was designed in parallel to the FragLites to cover a wider range of druggable interactionsin novel proteins. This library is still under evaluation but was highlighted in the mpro crystallographic screen carried out in March 2020 - link of bioRxiv here.
The research was carried out at the CRUK Newcastle Drug Discovery Unit, Newcastle University (Mike Waring and Martin Noble) and the main investigators were Gemma Davidson - synthetic chemistry, Selma Dormen - synthetic chemistry, James Sanderson - synthetic chemistry and Matthew Martin - structural biology insights
Compounds:
SMILES: click to download the PepLites platemap.
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