Principal Beamline Scientist:
Frank von Delft
Tel: +44 (0) 1235 778997
E-mail: [email protected]
Senior Beamline Scientist:
Daren Fearon
Tel: +44 (0) 1235 778936
E-mail: [email protected]
Email: [email protected]
Tel: +44 (0) 1235 778926
The MiniFrags, designed by Astex, are a set of small molecules representing the minimal pharmacophores able to capture the maximum amount of interactions in a protein. Whilst this library is available, the soaking conditions are still under evaluation. Screens have so far been conducted at 1M in DMSO.
Compounds:
SMILES:
O'Reilly, M., et al. Crystallographic screening using ultra-low molecular-weight ligands to guide drug design. Drug Discovery Today, (5) 1081-1086 (2019) (link to paper)
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