Fragment-based screening is now well-established as a powerful approach to early drug ("lead") discovery.
In the standard access, each proposal covers a single target. Proposals are evaluated by an independent Peer Review Panel (PRP) for access via one of two tiers:
Tier 1 Access:
While such proposals might have been unsuccessful previously; we are now welcoming them for initial feasibility assessment and (if required) discussions with the XChem team on formulating a credible hit follow-up strategy. Successful Tier 1 projects can be fast-tracked for Tier 2 access through rapid online peer-review.
Tier 2 Access:
Approved proposals are allocated a certain amount of beamtime, the use of which needs to be appropriately allocated to users. The PRP may decide to re-assign the tier that Diamond finally offers.
Applying for Standard Access is the same for each tier for both UK-based users and EU-based users applying via iNEXT Discovery:
Access for European (non-UK) users is funded by iNEXT-Discovery, which supports beamtime as well as travel and subsistence. Eligible proposals will be reviewed and ranked along with all other proposals, by the same peer review panel, so access will be determined entirely on scientific merit.
To allow eligible proposals to be tracked, the iNEXT “PID” is required.
Therefore, BEFORE SUBMITTING TO DIAMOND:
European users who do not follow these exact instructions will end up responsible for their own travel and subsistence, which might add up to a substantial cost, due to the nature of the experiment
Some instructions for specific fields are provided here:
Science overview tab:
Experimental methods tab
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