Fragment-based screening is now well-established as a powerful approach to early drug ("lead") discovery.
In the standard access, each proposal covers a single target. Proposals are evaluated by an independent Peer Review Panel (PRP) for access via one of two tiers:
Tier 1 Access:
While such proposals might have been unsuccessful previously; we are now welcoming them for initial feasibility assessment and (if required) discussions with the XChem team on formulating a credible hit follow-up strategy. Successful Tier 1 projects can be fast-tracked for Tier 2 access through rapid online peer-review.
Tier 2 Access:
Approved proposals are allocated a certain amount of beamtime, the use of which needs to be appropriately allocated to users. The PRP may decide to re-assign the tier that Diamond finally offers.
Currently, Tier 3 access to support hit follow-up chemistry is under discussion.
Applying for Standard Access:
XChem's users can access different European partnerships to help for access or hit-to-lead chemistry (iNEXT-DIscovery, EUbOPEN and EU-OPENSCREEN). More information on those partnerships and how to access them can be found here.
Some instructions for specific fields are provided here:
Science overview tab:
Experimental methods tab
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