Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04-1 Contact
Beamline Phone Number:
+44 (0) 1235 778979
Principal Beamline Scientist:
Frank von Delft
Tel: +44 (0) 1235 778997
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04-1 Fixed wavelength MX
Status: Operational
Beamsize: 60 x 50
Detector: Eiger2 XE 9M
Wavelength: 0.92Å (fixed)
Energy: 13.445 keV
Detector: Eiger2 XE 9M
Wavelength: 0.92Å (fixed)
Energy: 13.445 keV
These publications are based on data gathered on beamline I04-1. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
76 items found for 2014 [total: 1244]
Structure and function of a decarboxylating Agrobacterium tumefaciens keto-deoxy-d-galactarate dehydratase Biochemistry, 53 (51) Dec 2014 DOI: 10.1021/bi501290k
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase Nature, 516 (7529) Dec 2014 DOI: 10.1038/nature14003
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide Nature Structural & Molecular Biology, Dec 2014 DOI: 10.1038/nsmb.2935
Journal Paper B23-Circular Dichroism I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and Ponatinib in complex with FGFR1 and FGFR4 Structure, 22 (12) Dec 2014 DOI: 10.1016/j.str.2014.09.019
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Evolution of oligomeric state through allosteric pathways that mimic ligand binding Science, 346 (6216) Dec 2014 DOI: 10.1126/science.1254346
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Design, synthesis and structure–activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK) Bioorganic & Medicinal Chemistry Letters, 24 (24) Dec 2014 DOI: 10.1016/j.bmcl.2014.10.020
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor Elife, 3 Dec 2014 DOI: 10.7554/eLife.05553
Journal Paper B21-High Throughput SAXS I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
The crystal structures of Apo and cAMP-bound GlxR from Corynebacterium glutamicum reveal structural and dynamic changes upon cAMP binding in CRP/FNR family transcription factors Plos One, 9 (12) Dec 2014 DOI: 10.1371/journal.pone.0113265
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Crystal structure of deglycosylated human IgG4-Fc Molecular Immunology, 62 (1) Nov 2014 DOI: 10.1016/j.molimm.2014.05.015
Coevolution of the ATPase ClpV, the sheath proteins TssB and TssC, and the accessory protein TagJ/HsiE1 distinguishes type VI secretion classes Journal Of Biological Chemistry, 289 (47) Nov 2014 DOI: 10.1074/jbc.M114.600510
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure and function of a spectrin-like regulator of bacterial cytokinesis Nature Communications, 5 Nov 2014 DOI: 10.1038/ncomms6421
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies Nature, 515 (7527) Nov 2014 DOI: 10.1038/nature13715
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus Journal Of Biological Chemistry, 289 (48) Nov 2014 DOI: 10.1074/jbc.M114.608448
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
A disulfide polymerized protein crystal Chemical Communications, 50 (95) Oct 2014 DOI: 10.1039/C4CC07326F
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Crystallization and preliminary X-ray diffraction studies of the C-terminal domain of Chlamydia trachomatis CdsD Acta Crystallographica Section F Structural Biology Communications, 70 Oct 2014 DOI: 10.1107/S2053230X14019712
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structure-activity relationship of 3,5-Diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants Journal Of Medicinal Chemistry, 57 (19) Oct 2014 DOI: 10.1021/jm501177w
Structure-based design of potent and selective leishmaniaN-myristoyltransferase inhibitors Journal Of Medicinal Chemistry, 57 (20) Oct 2014 DOI: 10.1021/jm5011397
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
The structure of a tetrameric alpha-carbonic anhydrase from Thermovibrio ammonificans reveals a core formed around intermolecular disulfides that contribute to its thermostability Acta Crystallographica Section D Biological Crystallography, 70 Oct 2014 DOI: 10.1107/S1399004714016526
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly Plos Pathogens, 10 (10) Oct 2014 DOI: 10.1371/journal.ppat.1004459
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structure and function of cohesin's Scc3/SA regulatory subunit Febs Letters, 588 (20) Oct 2014 DOI: 10.1016/j.febslet.2014.08.015
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites Organic & Biomolecular Chemistry, 12 (41) Sept 2014 DOI: 10.1039/C4OB01669F
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor Medchemcomm, 5 (12) Sept 2014 DOI: 10.1039/C4MD00291A
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Latent and active abPPO4 mushroom tyrosinase cocrystallized with hexatungstotellurate(VI) in a single crystal Acta Crystallographica Section D Biological Crystallography, 70 Sept 2014 DOI: 10.1107/S1399004714013777
Structural and functional studies of conserved nucleotide-binding protein LptB in lipopolysaccharide transport Biochemical And Biophysical Research Communications, 452 (3) Sept 2014 DOI: 10.1016/j.bbrc.2014.08.094
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
The molecular mechanism of Shiga toxin Stx2e neutralization by a single-domain antibody targeting the cell receptor-binding domain Journal Of Biological Chemistry, 289 (36) Sept 2014 DOI: 10.1074/jbc.M114.566257
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
The structural basis of differential inhibition of human calpain by indole and phenyl alpha-mercaptoacrylic acids Journal Of Structural Biology, 187 (3) Sept 2014 DOI: 10.1016/j.jsb.2014.07.004
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimer’s disease Plos One, 9 (8) Aug 2014 DOI: 10.1371/journal.pone.0104001
Structural and mechanistic insight into the Listeria monocytogenes two-enzyme lipoteichoic acid synthesis system Journal Of Biological Chemistry, Aug 2014 DOI: 10.1074/jbc.M114.590570
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
I04-1, a fiture 'fragment screening' beamline facility at Diamond Light Source Aug 2014
Poster I04-1-Macromolecular Crystallography (fixed wavelength)
AP2 controls clathrin polymerization with a membrane-activated switch Science, 345 (6195) Jul 2014 DOI: 10.1126/science.1254836
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N -acetylgalactosaminyltransferase 2 Angewandte Chemie International Edition, 53 (31) Jul 2014 DOI: 10.1002/anie.201402781
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors Iucrj, 1 Jul 2014 DOI: 10.1107/S2052252514013001
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure of the NADH-dependent thermostable alcohol dehydrogenase TADH from Thermus sp. ATN1 provides a platform for engineering specificity and improved compatibility with inorganic cofactor-regeneration catalysts Journal Of Molecular Catalysis B: Enzymatic, 105 Jul 2014 DOI: 10.1016/j.molcatb.2014.03.013
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted Type II kinase inhibitors Journal Of Molecular Biology, 426 (13) June 2014 DOI: 10.1016/j.jmb.2014.04.014
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface Developmental Cell, 29 (5) June 2014 DOI: 10.1016/j.devcel.2014.04.010
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO Plos One, 9 (6) June 2014 DOI: 10.1371/journal.pone.0098896
The peptide-binding cavity is essential for Als3-mediated adhesion of Candida albicans to human cells Journal Of Biological Chemistry, 289 (26) June 2014 DOI: 10.1074/jbc.M114.547877
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation–π interaction Angewandte Chemie International Edition, 53 (24) June 2014 DOI: 10.1002/anie.201402750
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Human UTY(KDM6C) is a male-specific nϵ-methyl lysyl demethylase Journal Of Biological Chemistry, 289 (26) June 2014 DOI: 10.1074/jbc.M114.555052
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1 Structure, 22 (6) June 2014 DOI: 10.1016/j.str.2014.04.001
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism Proceedings Of The National Academy Of Sciences, 111 (23) June 2014 DOI: 10.1073/pnas.1406855111
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Structural and mutagenic analysis of the RM controller protein C.Esp1396I Plos One, 9 (6) June 2014 DOI: 10.1371/journal.pone.0098365
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Overproduction, purification, crystallization and preliminary X-ray characterization of the family 46 carbohydrate-binding module (CBM46) of endo-beta-1,4-glucanase B (CelB) from Bacillus halodurans Acta Crystallographica Section F Structural Biology Communications, 70 June 2014 DOI: 10.1107/S2053230X14008395
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
HELIX: a new modular nucleic acid crystallization screen Journal Of Applied Crystallography, 47 (3) June 2014 DOI: 10.1107/S1600576714007407
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Discovery of (10R)-7-smino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) Journal Of Medicinal Chemistry, 57 (11) June 2014 DOI: 10.1021/jm500261q
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway Molecular Microbiology, 93 (2) June 2014 DOI: 10.1111/mmi.12656
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Enhanced human receptor binding by H5 haemagglutinins Virology, 456 May 2014 DOI: 10.1016/j.virol.2014.03.008
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Bacterial actin MreB forms antiparallel double filaments Elife, 3 May 2014 DOI: 10.7554/eLife.02634
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors Science, 344 (6187) May 2014 DOI: 10.1126/science.1253397
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase Acta Crystallographica Section D Biological Crystallography, 70 May 2014 DOI: 10.1107/S1399004714005422
The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin Nature Communications, 5 May 2014 DOI: 10.1038/ncomms4726
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Completing the structural family portrait of the human EphB tyrosine kinase domains Protein Science, 23 (5) May 2014 DOI: 10.1002/pro.2445
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structure of the AcrAB-TolC multidrug efflux pump Nature, 509 (7501) May 2014 DOI: 10.1038/nature13205
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA Acta Crystallographica Section D Biological Crystallography, 70 May 2014 DOI: 10.1107/S139900471400501X
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca Febs Journal, 281 (9) May 2014 DOI: 10.1111/febs.12778
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Ribosomal oxygenases are structurally conserved from prokaryotes to humans Nature, 509 (7505) May 2014 DOI: 10.1038/nature13263
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides Nature Chemical Biology, 10 (5) Apr 2014 DOI: 10.1038/nchembio.1499
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Identification and characterization of the 'missing' terminal enzyme for siroheme biosynthesis in α-proteobacteria Molecular Microbiology, 92 (1) Apr 2014 DOI: 10.1111/mmi.12542
Structural insight into how Streptomyces coelicolor maltosyl transferase GlgE binds alpha-maltose 1-phosphate and forms a maltosyl-enzyme intermediate Biochemistry, 53 (15) Apr 2014 DOI: 10.1021/bi500183c
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Crenactin from Pyrobaculum calidifontis is closely related to actin in structure and forms steep helical filaments Febs Letters, 588 (5) Mar 2014 DOI: 10.1016/j.febslet.2014.01.029
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1 Nature, 507 (7490) Mar 2014 DOI: 10.1038/nature13116
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Structural and functional characterization of NanU, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling Bacteroidetes species Biochemical Journal, 458 Mar 2014 DOI: 10.1042/BJ20131415
A new crystal structure of the bifunctional antibiotic simocyclinone D8 bound to DNA gyrase gives fresh insight into the mechanism of inhibition Journal Of Molecular Biology, Mar 2014 DOI: 10.1016/j.jmb.2014.02.017
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Evidence for steric regulation of fibrinogen binding to Staphylococcus aureus Fibronectin-binding Protein A (FnBPA) Journal Of Biological Chemistry, Mar 2014 DOI: 10.1074/jbc.M113.543546
Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: implications for angiogenic regulation Blood, 123 (12) Mar 2014 DOI: 10.1182/blood-2013-11-535963
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural and mechanistic insights into an extracytoplasmic copper trafficking pathway in Streptomyces lividans Biochemical Journal, Feb 2014 DOI: 10.1042/BJ20140017
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor Plos Pathogens, 10 (2) Feb 2014 DOI: 10.1371/journal.ppat.1003898
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystallization and preliminary X-ray crystallographic analysis of latent isoform PPO4 mushroom (Agaricus bisporus) tyrosinase Acta Crystallographica Section F Structural Biology Communications, 70 (2) Feb 2014 DOI: 10.1107/S2053230X14000582
Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE) Journal Of Biological Chemistry, 289 (3) Jan 2014 DOI: 10.1074/jbc.M113.512335
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structures of complexes of a metal-independent glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-acetylgalactosamine (UDP-GalNAc) and its hydrolysis products Journal Of Biological Chemistry, Jan 2014 DOI: 10.1074/jbc.M113.545384
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structure and biochemical properties of the alkene producing cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium Journal Of Biological Chemistry, Jan 2014 DOI: 10.1074/jbc.M113.527325
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis Proceedings Of The National Academy Of Sciences, 111 (4) Jan 2014 DOI: 10.1073/pnas.1317488111
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Evaluation and structural basis for the inhibition of tankyrases by PARP inhibitors Acs Medicinal Chemistry Letters, 5 (1) Jan 2014 DOI: 10.1021/ml400292s
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Evidence that GH115 α-glucuronidase activity, which is required to degrade plant biomass, is dependent on conformational flexibility Journal Of Biological Chemistry, 289 (1) Jan 2014 DOI: 10.1074/jbc.M113.525295
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha Febs Letters, 588 (1) Jan 2014 DOI: 10.1016/j.febslet.2013.11.013
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Crystal structure of a Schistosoma mansoni septin reveals the phenomenon of strand slippage in septins dependent on the nature of the bound nucleotide Journal Of Biological Chemistry, 289 (11) Jan 2014 DOI: 10.1074/jbc.M113.525352
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
- Helena Taberman, Martina Andberg, Tarja Parkkinen, Janne Jänis, Merja Penttilä, Nina Hakulinen, Anu Koivula, Juha Rouvinen, "Structure and function of a decarboxylating Agrobacterium tumefaciens keto-deoxy-d-galactarate dehydratase", Biochemistry, 53 (51) (2014), DOI: 10.1021/bi501290k
- Julia Steuber, Georg Vohl, Marco S. Casutt, Thomas Vorburger, Kay Diederichs, Guenter Fritz, "Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase", Nature, 516 (7529), 62 - 67 (2014), DOI: 10.1038/nature14003
- Gregor Hagelueken, Bradley R Clarke, Hexian Huang, Anne Tuukkanen, Iulia Danciu, Dmitri I Svergun, Rohanah Hussain, Huanting Liu, Chris Whitfield, James Naismith, "A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide", Nature Structural & Molecular Biology (2014), DOI: 10.1038/nsmb.2935
- Julie A. Tucker, Tobias Klein, Jason Breed, Alexander l. Breeze, Ross Overman, Chris Phillips, Richard A. Norman, "Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and Ponatinib in complex with FGFR1 and FGFR4", Structure, 22 (12), 1764 - 1774 (2014), DOI: 10.1016/j.str.2014.09.019
- T. Perica, Y. Kondo, S. P. Tiwari, S. H. Mclaughlin, K. R. Kemplen, X. Zhang, A. Steward, N. Reuter, J. Clarke, S. A. Teichmann, "Evolution of oligomeric state through allosteric pathways that mimic ligand binding", Science, 346 (6216), 1254346 - 1254346 (2014), DOI: 10.1126/science.1254346
- Giancarlo Trani, John J. Barker, Steven M. Bromidge, Frederick A. Brookfield, Jason D. Burch, Yuan Chen, Charles Eigenbrot, Alexander Heifetz, M. Hicham A. Ismaili, Adam Johnson, Thomas M. Krülle, Colin H. Mackinnon, Rosemary Maghames, Paul A. Mcewan, Christian A.g.n. Montalbetti, Daniel F. Ortwine, Yolanda Pérez-Fuertes, Darshan G. Vaidya, Xiaolu Wang, Ali A. Zarrin, "Design, synthesis and structure–activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)", Bioorganic & Medicinal Chemistry Letters, 24 (24), 5818 - 5823 (2014), DOI: 10.1016/j.bmcl.2014.10.020
- Harriet Lane-Serff, Paula Macgregor, Ed Lowe, Mark Carrington, Matthew K Higgins, "Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor", Elife, 3 (2014), DOI: 10.7554/eLife.05553
- Philip D. Townsend, Britta Jungwirth, Florence Pojer, Michael Bußmann, Victoria A. Money, Stewart T. Cole, Alfred Pühler, Andreas Tauch, Michael Bott, Martin J. Cann, Ehmke Pohl, "The crystal structures of Apo and cAMP-bound GlxR from Corynebacterium glutamicum reveal structural and dynamic changes upon cAMP binding in CRP/FNR family transcription factors", Plos One, 9 (12) (2014), DOI: 10.1371/journal.pone.0113265
- Anna M. Davies, Roy Jefferis, Brian J. Sutton, "Crystal structure of deglycosylated human IgG4-Fc", Molecular Immunology, 62 (1), 46 - 53 (2014), DOI: 10.1016/j.molimm.2014.05.015
- Andreas Forster, Sara Planamente, Eleni Manoli, Nadine. S. Lossi, Paul Freemont, Alain. Filloux, "Coevolution of the ATPase ClpV, the sheath proteins TssB and TssC, and the accessory protein TagJ/HsiE1 distinguishes type VI secretion classes", Journal Of Biological Chemistry, 289 (47), 33032 - 33043 (2014), DOI: 10.1074/jbc.M114.600510
- Robert Cleverley, Jeffrey R. Barrett, Arnaud Basle, Nhat Khai Bui, Lorraine Hewitt, Alexandra Solovyova, Zhi-Qiang Xu, Richard A. Daniel, Nicholas E. Dixon, Elizabeth J. Harry, Aaron J. Oakley, Waldemar Vollmer, Richard J/ Lewis, "Structure and function of a spectrin-like regulator of bacterial cytokinesis", Nature Communications, 5 (2014), DOI: 10.1038/ncomms6421
- Katherine E. Wright, Kathryn A. Hjerrild, Jonathan Bartlett, Alexander D. Douglas, Jing Jin, Rebecca E. Brown, Joseph J. Illingworth, Rebecca Ashfield, Stine B. Clemmensen, Willem A. De Jongh, Simon J. Draper, Matthew K. Higgins, "Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies", Nature, 515 (7527), 427 - 430 (2014), DOI: 10.1038/nature13715
- V. Karuppiah, A. Thistlethwaite, R. Dajani, J. Warwicker, J. P Derrick, "Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus", Journal Of Biological Chemistry, 289 (48), 33187 - 33197 (2014), DOI: 10.1074/jbc.M114.608448
- Esben Quistgaard, "A disulfide polymerized protein crystal", Chemical Communications, 50 (95), 14995 - 14997 (2014), DOI: 10.1039/C4CC07326F
- Gitte Meriläinen, Rik K. Wierenga, "Crystallization and preliminary X-ray diffraction studies of the C-terminal domain of Chlamydia trachomatis CdsD", Acta Crystallographica Section F Structural Biology Communications, 70, 1431 - 1433 (2014), DOI: 10.1107/S2053230X14019712
- Agustin H. Mohedas, You Wang, Caroline E. Sanvitale, Peter Canning, Sungwoon Choi, Xuechao Xing, Alex N. Bullock, Gregory D. Cuny, Paul B. Yu, "Structure-activity relationship of 3,5-Diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants", Journal Of Medicinal Chemistry, 57 (19), 7900 - 7915 (2014), DOI: 10.1021/jm501177w
- Jennie A. Hutton, Victor Goncalves, James A. Brannigan, Daniel Paape, Megan H. Wright, Thomas M. Waugh, Shirley Roberts, Andrew S. Bell, Anthony Wilkinson, Deborah F. Smith, Robin J. Leatherbarrow, Edward W. Tate, "Structure-based design of potent and selective leishmaniaN-myristoyltransferase inhibitors", Journal Of Medicinal Chemistry, 57 (20), 8664 - 8670 (2014), DOI: 10.1021/jm5011397
- Paul James, Misha Isupov, Christopher Sayer, Vahid Saneei, Svein Berg, Maria Lioliou, Hans Kristian Kotlar, Jennifer Littlechild, "The structure of a tetrameric alpha-carbonic anhydrase from Thermovibrio ammonificans reveals a core formed around intermolecular disulfides that contribute to its thermostability", Acta Crystallographica Section D Biological Crystallography, 70, 2607 - 2618 (2014), DOI: 10.1107/S1399004714016526
- Amanda J. Price, David Jacques, William A. Mcewan, Adam J. Fletcher, Sebastian Essig, Jason W. Chin, Upul D. Halambage, Christopher Aiken, Leo C. James, "Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly", Plos Pathogens, 10 (10) (2014), DOI: 10.1371/journal.ppat.1004459
- Maurici B. Roig, Jan Lowe, Kok-Lung Chan, Frédéric Beckouët, Jean Metson, Kim Nasmyth, "Structure and function of cohesin's Scc3/SA regulatory subunit", Febs Letters, 588 (20), 3692 - 3702 (2014), DOI: 10.1016/j.febslet.2014.08.015
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- Katherine S. England, Anthony Tumber, Tobias Krojer, Guiseppe Scozzafava, Stanley Ng, Michelle Daniel, Aleksandra Szykowska, Kahing Che, Frank Von Delft, Nicola A. Burgess-Brown, Akane Kawamura, Christopher J. Schofield, Paul E. Brennan, "Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor", Medchemcomm, 5 (12), 1879 - 1886 (2014), DOI: 10.1039/C4MD00291A
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- [Poster] Alice Douangamath, Jose Brandao-Neto, Mark Williams, Richard Fearn, Tobias Krojer, Pierre Aller, Keith Henderson, Emily Longhi, L Allianelli, Frank Von Delft, "I04-1, a fiture 'fragment screening' beamline facility at Diamond Light Source" (2014)
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- Anne Cleasby, Jeff Yon, Philip J. Day, Caroline Richardson, Ian J. Tickle, Pamela A. Williams, James F. Callahan, Robin Carr, Nestor Concha, Jeffrey K. Kerns, Hongwei Qi, Thomas Sweitzer, Paris Ward, Thomas G. Davies, "Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO", Plos One, 9 (6) (2014), DOI: 10.1371/journal.pone.0098896
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- Louise J. Walport, Richard J. Hopkinson, Melanie Vollmar, Sarah K. Madden, Carina Gileadi, U. Oppermann, Christopher J. Schofield, Catrine Johansson, "Human UTY(KDM6C) is a male-specific nϵ-methyl lysyl demethylase", Journal Of Biological Chemistry, 289 (26), 18302 - 18313 (2014), DOI: 10.1074/jbc.M114.555052
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- Richard Martin, John Mcgeehan, Geoff Kneale, "Structural and mutagenic analysis of the RM controller protein C.Esp1396I", Plos One, 9 (6) (2014), DOI: 10.1371/journal.pone.0098365
- Immacolata Venditto, Helena Santos, Luís M. A. Ferreira, Kazuo Sakka, Carlos M. G. A. Fontes, Shabir Najmudin, "Overproduction, purification, crystallization and preliminary X-ray characterization of the family 46 carbohydrate-binding module (CBM46) of endo-beta-1,4-glucanase B (CelB) from Bacillus halodurans", Acta Crystallographica Section F Structural Biology Communications, 70, 754 - 757 (2014), DOI: 10.1107/S2053230X14008395
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- David J. Palmer, Susanne Schroeder, Andrew D. Lawrence, Evelyne Deery, Susana A. Lobo, Ligia M. Saraiva, Kirsty J. Mclean, Andrew W. Munro, Stuart J. Ferguson, Richard W. Pickersgill, David G. Brown, Martin J. Warren, "The structure, function and properties of sirohaem decarboxylase - an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway", Molecular Microbiology, 93 (2), 247 - 261 (2014), DOI: 10.1111/mmi.12656
- Xiaoli Xiong, Haixia Xiao, Stephen R. Martin, Peter J. Coombs, Junfeng Liu, Patrick Collins, Sebastien Vachieri, Phil Walker, Yi Pu Lin, John W. Mccauley, Steven Gamblin, John J. Skehel, "Enhanced human receptor binding by H5 haemagglutinins", Virology, 456, 179 - 187 (2014), DOI: 10.1016/j.virol.2014.03.008
- Fusinita Van Den Ent, Thierry Izoré, Tanmay Am Bharat, Christopher M Johnson, Jan Lowe, "Bacterial actin MreB forms antiparallel double filaments", Elife, 3 (2014), DOI: 10.7554/eLife.02634
- John Burke, Alison J. Inglis, Olga Perisic, Glenn R. Masson, Stephen H. Mclaughlin, Florentine Rutaganira, Kevan M. Shokat, Roger L. Williams, "Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors", Science, 344 (6187), 1035 - 1038 (2014), DOI: 10.1126/science.1253397
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