Instruments by Science Group
Macromolecular
Soft Condensed 
Imaging and
Biological
Magnetic
Structures and
Crystallography 
Spectroscopy I04-1 Contact
Beamline Phone Number:
+44 (0) 1235 778979
Principal Beamline Scientist:
Frank von Delft
Tel: +44 (0) 1235 778997
E-mail: [email protected]
Science Group Leader
Dave Hall
Email: [email protected]
Tel: +44 (0) 1235 778926
I04-1 Fixed wavelength MX
Status: Operational
Beamsize: 60 x 50
Detector: Eiger2 XE 9M
Wavelength: 0.92Å (fixed)
Energy: 13.445 keV
Detector: Eiger2 XE 9M
Wavelength: 0.92Å (fixed)
Energy: 13.445 keV
These publications are based on data gathered on beamline I04-1. If you are aware of any errors or publications that should be listed here, please send details to [email protected].
72 items found for 2013 [total: 1244]
Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1 Nature, 504 (7479) Dec 2013 DOI: 10.1038/nature12754
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1) Journal Of Medicinal Chemistry, 56 (24) Dec 2013 DOI: 10.1021/jm401395s
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural snapshots illustrate the catalytic cycle of β-galactocerebrosidase, the defective enzyme in Krabbe disease Proceedings Of The National Academy Of Sciences, Dec 2013 DOI: 10.1073/pnas.1311990110
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach Nature Chemistry, 6 (2) Dec 2013 DOI: 10.1038/nchem.1830
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay Biochemistry, 52 (51) Dec 2013 DOI: 10.1021/bi400945y
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
8-substituted O6-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode Journal Of Medicinal Chemistry, 57 (1) Dec 2013 DOI: 10.1021/jm401555v
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre Molecular Microbiology, Nov 2013 DOI: 10.1111/mmi.12447
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme Febs Journal, Nov 2013 DOI: 10.1111/febs.12660
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin Nature Communications, 4 Nov 2013 DOI: 10.1038/ncomms3787
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural insights into how 5-hydroxymethylation influences transcription factor binding Chemical Communications, 50 (15) Nov 2013 DOI: 10.1039/C3CC48151D
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Identification, characterization and preliminary X-ray diffraction analysis of the rolling-circle replication initiator protein from plasmid pSTK1 Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Oct 2013 DOI: 10.1107/S1744309113023828
Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP Nature, Oct 2013 DOI: 10.1038/nature12638
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification Nucleic Acids Research, Oct 2013 DOI: 10.1093/nar/gkt931
A structural and dynamic investigation of the inhibition of catalase by nitric oxide Organic & Biomolecular Chemistry, 11 (44) Oct 2013 DOI: 10.1039/c3ob41977k
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Para substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors Chemmedchem, Oct 2013 DOI: 10.1002/cmdc.201300337
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Crystal structure of the Psb28 accessory factor of Thermosynechococcus elongatus photosystem II at 2.3 Å Photosynthesis Research, Oct 2013 DOI: 10.1007/s11120-013-9939-6
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP Acta Crystallographica Section D Biological Crystallography, 69 Sept 2013 DOI: 10.1107/S0907444913012687
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Role of the C-terminal domain in the structure and function of tetrameric sodium channels Nature Communications, 4 Sept 2013 DOI: 10.1038/ncomms3465
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
On the catalytic mechanism of dimeric dUTPases Biochemical Journal, Sept 2013 DOI: 10.1042/BJ20130796
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus Virus Research, Sept 2013 DOI: 10.1016/j.virusres.2013.08.007
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity Journal Of Medicinal Chemistry, 56 (20) Sept 2013 DOI: 10.1021/jm401463y
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases Nucleic Acids Research, Sept 2013 DOI: 10.1093/nar/gkt776
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1 Molecular Cell, 51 (6) Sept 2013 DOI: 10.1016/j.molcel.2013.08.030
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitors Chemmedchem, Sept 2013 DOI: 10.1002/cmdc.201300274
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Fragment-based design for the development of N-domain selective angiotensin-1 converting enzyme inhibitors Clinical Science, Sept 2013 DOI: 10.1042/CS20130403
Characterization of 14-3-3-ζ interactions with integrin tails Journal Of Molecular Biology, 425 (17) Sept 2013 DOI: 10.1016/j.jmb.2013.05.024
Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1 Nature Structural & Molecular Biology, Sept 2013 DOI: 10.1038/nsmb.2668
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains Journal Of Medicinal Chemistry, 56 (19) Sept 2013 DOI: 10.1021/jm401088k
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity Acta Crystallographica Section D Biological Crystallography, 69 Aug 2013 DOI: 10.1107/S0907444913015126
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport Nucleic Acids Research, Aug 2013 DOI: 10.1093/nar/gkt749
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Accessibility, reactivity, and selectivity of side chains within a channel of de Novo peptide assembly Journal Of The American Chemical Society, 135 (34) Aug 2013 DOI: 10.1021/ja4053027
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
The chemical basis of serine palmitoyltransferase inhibition by myriocin Journal Of The American Chemical Society, Aug 2013 DOI: 10.1021/ja4059876
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural rearrangement in an RsmA/CsrA ortholog of Pseudomonas aeruginosa creates a dimeric RNA-binding protein, RsmN Structure, Aug 2013 DOI: 10.1016/j.str.2013.07.007
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
Crystallization and preliminary X-ray diffraction analysis of selenophosphate synthetases from Trypanosoma brucei and Leishmania major Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Aug 2013 DOI: 10.1107/S1744309113014632
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling Structure, 21 (9) Aug 2013 DOI: 10.1016/j.str.2013.07.005
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Tying down the arm in Bacillus dUTPase: structure and mechanism Acta Crystallographica Section D Biological Crystallography, 69 Aug 2013 DOI: 10.1107/S090744491300735X
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Binding of (5S)-penicilloic acid to penicillin binding protein 3 Acs Chemical Biology, 8 (10) Aug 2013 DOI: 10.1021/cb400200h
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism Journal Of Medicinal Chemistry, 56 (16) Jul 2013 DOI: 10.1021/jm4006274
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography Acta Crystallographica Section D Biological Crystallography, 69 Jul 2013 DOI: 10.1107/S0907444913012274
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Structural basis of Vps33A recruitment to the human HOPS complex by Vps16 Proceedings Of The National Academy Of Sciences, Jul 2013 DOI: 10.1073/pnas.1307074110
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Squeezing the most from every crystal: the fine details of data collection Acta Crystallographica Section D Biological Crystallography, 69 Jul 2013 DOI: 10.1107/S0907444913013280
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase Nucleic Acids Research, Jul 2013 DOI: 10.1093/nar/gkt633
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation Proceedings Of The National Academy Of Sciences, Jul 2013 DOI: 10.1073/pnas.1311113110
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography open access
α-L-fucosidase inhibition by pyrrolidine–ferrocene hybrids: rationalization of ligand-binding properties by structural studies Chemistry - A European Journal, 19 (29) Jul 2013 DOI: 10.1002/chem.201301001
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Key mutations alter the cytochrome P450 BM3 conformational landscape and remove inherent substrate bias Journal Of Biological Chemistry, 288 (35) Jul 2013 DOI: 10.1074/jbc.M113.479717
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structure and activity of NADPH-dependent reductase Q1EQE0 from Streptomyces kanamyceticus, which catalyses the R-selective reduction of an imine substrate Chembiochem, 14 (11) Jul 2013 DOI: 10.1002/cbic.201300321
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structural characterization of a unique marine animal family 7 cellobiohydrolase suggests a mechanism of cellulase salt tolerance Proceedings Of The National Academy Of Sciences, 110 (25) June 2013 DOI: 10.1073/pnas.1301502110
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Receptor binding by an H7N9 influenza virus from humans Nature, June 2013 DOI: 10.1038/nature12372
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
OTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin Cell, 153 (6) June 2013 DOI: 10.1016/j.cell.2013.05.014
Structurally encoded intraclass differences in EphA clusters drive distinct cell responses Nature Structural & Molecular Biology, 20 (8) June 2013 DOI: 10.1038/nsmb.2617
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing Biochemical Journal, 452 June 2013 DOI: 10.1042/BJ20130269
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human Immunoglobulin E Journal Of Biological Chemistry, June 2013 DOI: 10.1074/jbc.M113.480657
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry Proceedings Of The National Academy Of Sciences, June 2013 DOI: 10.1073/pnas.1302721110
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121 Chemmedchem, 8 (9) June 2013 DOI: 10.1002/cmdc.201300219
Using high-throughput in situ plate screening to evaluate the effect of dehydration on protein crystals Acta Crystallographica Section D Biological Crystallography, 69 May 2013 DOI: 10.1107/S0907444913002412
Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex Molecular Cell, May 2013 DOI: 10.1016/j.molcel.2013.04.024
Crystallization and preliminary X-ray analysis of a UDP-MurNAc-tripeptide D -alanyl- D -alanine-adding enzyme (PaMurF) from Pseudomonas aeruginosa Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 (5) May 2013 DOI: 10.1107/S1744309113005344
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Investigating the active centre of the S. thermophilum catalase Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69 Apr 2013 DOI: 10.1107/S1744309113004211
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography
Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization Nucleic Acids Research, Apr 2013 DOI: 10.1093/nar/gkt268
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography I24-Microfocus Macromolecular Crystallography open access
Receptor binding by a ferret-transmissible H5 avian influenza virus Nature, 497 (7449) Apr 2013 DOI: 10.1038/nature12144
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength)
Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum Acta Crystallographica Section D Biological Crystallography, 69 Mar 2013 DOI: 10.1107/S0907444912049001
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I04-Macromolecular Crystallography
Phage dUTPases control transfer of virulence genes by a proto-oncogenic G protein-like mechanism Molecular Cell, 49 (5) Mar 2013 DOI: 10.1016/j.molcel.2012.12.013
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
The copper active site of CBM33 polysaccharide oxygenases Journal Of The American Chemical Society, 135 (16) Mar 2013 DOI: 10.1021/ja402106e
Journal Paper B18-Core EXAFS I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Dimerization of complement factor H-related proteins modulates complement activation in vivo Proceedings Of The National Academy Of Sciences, 110 (12) Mar 2013 DOI: 10.1073/pnas.1219260110
Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine with γ-thialysine by using a chemical mutagenesis strategy Chembiochem, Feb 2013 DOI: 10.1002/cbic.201200714
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structural insights into the activation of MST3 by MO25 Biochemical And Biophysical Research Communications, 431 (3) Feb 2013 DOI: 10.1016/j.bbrc.2012.12.113
Structure of a VP1-VP3 complex suggests how birnaviruses package the VP1 polymerase Journal Of Virology, 87 (6) Feb 2013 DOI: 10.1128/JVI.02939-12
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography Febs Letters, Feb 2013 DOI: 10.1016/j.febslet.2013.01.065
Journal Paper I04-1-Macromolecular Crystallography (fixed wavelength)
Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases Journal Of Biological Chemistry, Jan 2013 DOI: 10.1074/jbc.M112.437996
Journal Paper I02-Macromolecular Crystallography I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) I24-Microfocus Macromolecular Crystallography open access
Structural insights into the mechanism and inhibition of the β-hydroxydecanoyl-acyl carrier protein dehydratase from Pseudomonasaeruginosa Journal Of Molecular Biology, 425 (2) Jan 2013 DOI: 10.1016/j.jmb.2012.11.017
Journal Paper I02-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4 Plos One, 8 (6) Jan 2013 DOI: 10.1371/journal.pone.0065404
Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity Proceedings Of The National Academy Of Sciences, 110 (5) Jan 2013 DOI: 10.1073/pnas.1214943110
Journal Paper I03-Macromolecular Crystallography I04-1-Macromolecular Crystallography (fixed wavelength) open access
- Ioannis Manolaridis, Kiran Kulkarni, Roger B. Dodd, Satoshi Ogasawara, Ziguo Zhang, Ganka Bineva, Nicola O'Reilly, Sarah J. Hanrahan, Andrew Thompson, Nora Cronin, So Iwata, David Barford, "Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1", Nature, 504 (7479), 301 - 305 (2013), DOI: 10.1038/nature12754
- Sébastien Naud, Isaac M. Westwood, Amir Faisal, Peter Sheldrake, Vassilios Bavetsias, Butrus Atrash, Kwai-Ming J. Cheung, Manjuan Liu, Angela Hayes, Jessica Schmitt, Amy Wood, Vanessa Choi, Kathy Boxall, Grace Mak, Mark Gurden, Melanie Valenti, Alexis De Haven Brandon, Alan Henley, Ross Baker, Craig Mcandrew, Berry Matijssen, Rosemary Burke, Swen Hoelder, Suzanne A. Eccles, Florence I. Raynaud, Spiros Linardopoulos, Rob L. M. Van Montfort, Julian Blagg, "Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)", Journal Of Medicinal Chemistry, 56 (24), 10045 - 10065 (2013), DOI: 10.1021/jm401395s
- Chris C. Hill, Stephen C. Graham, Randy J. Read, Janet E. Deane, "Structural snapshots illustrate the catalytic cycle of β-galactocerebrosidase, the defective enzyme in Krabbe disease", Proceedings Of The National Academy Of Sciences (2013), DOI: 10.1073/pnas.1311990110
- Megan H. Wright, Barbara Clough, Mark D. Rackham, Kaveri Rangachari, James A. Brannigan, Munira Grainger, David Moss, Andrew R. Bottrill, William P. Heal, Malgorzata Broncel, Remigiusz A. Serwa, Declan Brady, David J. Mann, Robin J. Leatherbarrow, Rita Tewari, Anthony Wilkinson, Anthony A. Holder, Edward W. Tate, "Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach", Nature Chemistry, 6 (2), 112 - 121 (2013), DOI: 10.1038/nchem.1830
- Gustavo A. Afanador, Stephen Muench, Martin Mcphillie, Alina Fomovska, Arne Schön, Ying Zhou, Gang Cheng, Jozef Stec, Joel S. Freundlich, Hong-Ming Shieh, John W. Anderson, David P. Jacobus, David A. Fidock, Alan P. Kozikowski, Colin W. Fishwick, David W. Rice, Ernesto Freire, Rima Mcleod, Sean T. Prigge, "Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay", Biochemistry, 52 (51), 9155 - 9166 (2013), DOI: 10.1021/bi400945y
- Benoit Carbain, David J. Paterson, Elizabeth Anscombe, Allyson J. Campbell, Celine Cano, Aude Echalier, Jane A. Endicott, Bernard T. Golding, Karen Haggerty, Ian R. Hardcastle, Philip J. Jewsbury, David R. Newell, Martin E. M. Noble, Celine Roche, Lan Z. Wang, Roger J. Griffin, "8-substituted O6-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding mode", Journal Of Medicinal Chemistry, 57 (1), 56 - 70 (2013), DOI: 10.1021/jm401555v
- Domenico Bellini, Delphine L. Caly, Yvonne Mccarthy, Mario Bumann, Shi-Qi An, J. Maxwell Dow, Robert P. Ryan, Martin A. Walsh, "Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre", Molecular Microbiology (2013), DOI: 10.1111/mmi.12447
- Geoffrey Masuyer, Akif Mohd, Bertrand Czarny, Fabrice Beau, Sylva L. U. Schwager, Edward D. Sturrock, R. Elwyn Isaac, Vincent Dive, K. Ravi Acharya, "Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme", Febs Journal (2013), DOI: 10.1111/febs.12660
- Matthias Zebisch, Yang Xu, Christos Krastev, Bryan T. Macdonald, Maorong Chen, Robert J. C. Gilbert, Xi He, Edith Jones, "Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin", Nature Communications, 4 (2013), DOI: 10.1038/ncomms3787
- Lukas Lercher, Michael A. Mcdonough, Afaf H. El-Sagheer, Armin Thalhammer, Skirmantas Kriaucionis, Tom Brown, Christopher J. Schofield, "Structural insights into how 5-hydroxymethylation influences transcription factor binding", Chemical Communications, 50 (15), 1794 - 1796 (2013), DOI: 10.1039/C3CC48151D
- Stephen Carr, Lauren B. Mecia, Simon Phillips, Christopher D. Thomas, "Identification, characterization and preliminary X-ray diffraction analysis of the rolling-circle replication initiator protein from plasmid pSTK1", Acta Crystallographica Section F Structural Biology And Crystallization Communications, 69, 1123 - 1126 (2013), DOI: 10.1107/S1744309113023828
- Ben Stieglitz, Rohini Rana, Marios Koliopoulos, Aylin C. Morris-Davies, Veronique Schaeffer, Evangelos Christodoulou, Steven Howell, Nick Brown, Ivan Dikic, Katrin Rittinger, "Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP", Nature (2013), DOI: 10.1038/nature12638
- Ingrid Dreveny, Sian E. Deeves, Joel Fulton, Baigong Yue, Marie Messmer, Amit Bhattacharya, Hilary M. Collins, David M. Heery, "The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification", Nucleic Acids Research (2013), DOI: 10.1093/nar/gkt931
- Marco Candelaresi, Andrea Gumiero, Katrin Adamczyk, Kirsty Robb, César Bellota-Antón, Vartul Sangal, John Munnoch, Gregory M. Greetham, Mike Towrie, Paul A. Hoskisson, Anthony W. Parker, Nicholas P. Tucker, Martin A. Walsh, Neil T. Hunt, "A structural and dynamic investigation of the inhibition of catalase by nitric oxide", Organic & Biomolecular Chemistry, 11 (44) (2013), DOI: 10.1039/c3ob41977k
- Teemu Haikarainen, Jarkko Koivunen, Mohit Narwal, Harikanth Venkannagari, Ezeogo Obaji, Päivi Joensuu, Taina Pihlajaniemi, Lari Lehtiö, "Para substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors", Chemmedchem (2013), DOI: 10.1002/cmdc.201300337
- Wojciech Bialek, Songjia Wen, Franck Michoux, Martina Beckova, Josef Komenda, James W. Murray, Peter Nixon, "Crystal structure of the Psb28 accessory factor of Thermosynechococcus elongatus photosystem II at 2.3 Å", Photosynthesis Research (2013), DOI: 10.1007/s11120-013-9939-6
- Laura K. Van Geersdaele, Mark A. Stead, Christopher M. Harrison, Stephen B. Carr, Helen J. Close, Gareth O. Rosbrook, Simon D. Connell, Stephanie C. Wright, "Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP", Acta Crystallographica Section D Biological Crystallography, 69, 1677 - 1684 (2013), DOI: 10.1107/S0907444913012687
- Claire Bagneris, Paul G. Decaen, Benjamin A. Hall, Claire E. Naylor, David E. Clapham, Christopher W. M. Kay, Bonnie A. Wallace, "Role of the C-terminal domain in the structure and function of tetrameric sodium channels", Nature Communications, 4, 7195-7197 (2013), DOI: 10.1038/ncomms3465
- Glyn Hemsworth, Dolores González-Pacanowska, Keith Wilson, "On the catalytic mechanism of dimeric dUTPases", Biochemical Journal (2013), DOI: 10.1042/BJ20130796
- X. Xiong, A. Tuzikov, P. J. Coombs, S. R, Martin, P. A. Walker, S. J. Gamblin, N. Bovin, J. J. Skehel, "Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus", Virus Research (2013), DOI: 10.1016/j.virusres.2013.08.007
- Mohit Narwal, Jarkko Koivunen, Teemu Haikarainen, Ezeogo Obaji, Ongey Elvis Legala, Harikanth Venkannagari, Päivi Joensuu, Taina Pihlajaniemi, Lari Lehtio, "Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity", Journal Of Medicinal Chemistry, 56 (20) (2013), DOI: 10.1021/jm401463y
- Stacey M. Southall, Nora B. Cronin, Jon R. Wilson, "A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases", Nucleic Acids Research (2013), DOI: 10.1093/nar/gkt776
- Meng Qu, Mathieu Rappas, Christopher P. Wardlaw, Valerie Garcia, Jing-Yi Ren, Matthew Day, Antony M. Carr, Antony W. Oliver, Li-Lin Du, Laurence H. Pearl, "Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1", Molecular Cell, 51 (6), 723 - 736 (2013), DOI: 10.1016/j.molcel.2013.08.030
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